Alicyclic Ring Or Ring System, Having Plural Amino Nitrogens Attached Directly Or Indirectly Thereto By Acyclic Nonionic Bonding, Attached Indirectly To An Aryl Ring Or Ring System By Acyclic Nonionic Bonding Patents (Class 564/306)
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Publication number: 20090153039Abstract: The present invention relates to novel organic electroluminescent compounds, organic electroluminescent devices and organic solar cells comprising the same. Specifically, the organic electroluminescent compounds according to the invention are represented by Chemical Formula (1): wherein, R1 and R2 independently represent hydrogen, deuterium, linear or branched (C1-C20)alkyl, (C2-C20)alkenyl, (C2-C20)alkynyl, (C3-C15)cycloalkyl, tri(C1-C20)alkylsilyl, di(C1-C20)alkyl(C6-C20)arylsilyl, tri(C6-C20)arylsilyl, adamantyl, (C7-C15)bicycloalkyl or (C4-C20)heteroaryl, and the alkyl, alkenyl, alkynyl, cycloalkyl, trialkylsilyl, dialkylarylsilyl, triarylsilyl, adamantyl, bicycloalkyl or heteroaryl of R1 and R2 may be further substituted by one or more substituent(s) selected from deuterium, linear or branched (C1-C20)alkyl, (C1-C20)alkenyl, (C1-C20)alkynyl, halogen, phenyl, fluorenyl, naphthyl and anthryl.Type: ApplicationFiled: November 19, 2008Publication date: June 18, 2009Applicant: Gracel Display Inc.Inventors: Bo Ra Kim, Mi Ae Lee, Chi Sik Kim, Soo Yong Lee, Young Jun Cho, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon
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Publication number: 20090112003Abstract: The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.Type: ApplicationFiled: October 22, 2008Publication date: April 30, 2009Inventor: Xun Li
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Publication number: 20090093521Abstract: Synthesis of 2,5-bis-diamine-[1,4]benzoquinonic derivatives having the general formula (I), products and intermediates of said synthesis; the synthesis involves the use of p-benzoquinones having the general formula (IX) and diamines having the general formula (XI).Type: ApplicationFiled: June 13, 2005Publication date: April 9, 2009Inventors: Maria Laura Bolognesi, Rita Banzi, Anna Minarini, Carlo Melchiorre
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Patent number: 7501453Abstract: Disclosed are aromatic cyclopropane compounds with CNS activity. These compounds can be used for alleviating symptoms of CNS disorders.Type: GrantFiled: March 12, 2007Date of Patent: March 10, 2009Assignee: The Research Foundation of State University of New YorkInventors: Huw M. L. Davies, Timothy Gregg
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Publication number: 20080299474Abstract: A high quality hole transport material of a substituted biphenyl diamine, such as N,N,N?N?-tetra(4-methylphenyl)-(1,1?-biphenyl)-4,4?-diamine, where each X is independently selected from —H, alkyl(-CnH2n+1), where n is from 1 to about 10 such as from 1 to about 5 or from 1 to about 6, aralkyl and aryl groups, the aralkyl and aryl groups having, for example, from about 5 to about 30, such as about 6 to about 20 carbon atoms, where the purity of the hole transport material is from about 80 percent to about 100 percent, and when incorporated into a photoreceptor, the photoreceptor discharges from about 85% to about 100% of its surface potential in from 0 to about 40 milliseconds upon being subjected to xerographic charging and exposure to radiant energy of from about 1 ergs/cm2 to about, 5 ergs/cm2. Also disclosed is a photoreceptor containing the same.Type: ApplicationFiled: May 31, 2007Publication date: December 4, 2008Applicant: XEROX CORPORATIONInventors: Gregory MCGUIRE, Jennifer A. COGGAN, Hany AZIZ, Johann JUNGINGER, Nan-Xing HU, Ah-Mee Hor
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Publication number: 20080241591Abstract: The invention is to provide an organic EL device having a long life time that can reduce the driving voltage of the organic EL device, and to provide a material having a small ionization potential and exhibiting a large hole mobility by using as a layer or a zone. The organic electroluminescence device comprises a pair of electrodes and an organic light emitting layer sandwiched in the electrodes, characterized in that a hole transporting zone provided between the electrodes comprises the phenylenediamine derivative represented by the specific structural formulae, and the phenylenediamine derivative has a hole mobility of 10?4 cm2/V·s or more upon using as a layer or a zone, with the organic light emitting layer containing a charge injection auxiliary.Type: ApplicationFiled: June 3, 2008Publication date: October 2, 2008Applicant: Idemitsu Kosan Co., Ltd.Inventors: Hisayuki KAWAMURA, Chishio HOSOKAWA
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Publication number: 20080221355Abstract: A method of producing a near-infrared absorbing dye compound, useful for image forming materials, infrared heat-sensitive recording devices, optical film materials, and the like, containing a process of reacting a compound represented by formula (I) with peroxomonosulfuric acid or its salt. wherein R111, R112, R121, R122, R131, R132, R141 and R142 each independently represent a hydrogen atom, an aliphatic group or an aromatic group; R103, R113, R123, R133 and R143 each independently represent a substituent; and n103, n113, n123, n133 and n143 each independently denote an integer from 0 to 4.Type: ApplicationFiled: September 1, 2006Publication date: September 11, 2008Applicant: FUJI PHOTO FILM CO., LTD.Inventors: Keizo Kimura, Tomohito Masaki, Osamu Uchida, Katsuyoshi Yamakawa
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Publication number: 20080194788Abstract: This invention provides aromatic diimines where the diimines have imino groups with at least two carbon atoms, and either are in the form of one benzene ring having two imino groups on the ring, which imino groups are meta or para relative to each other, and in which each position ortho to an imino group bears a hydrocarbyl group, or are in the form of two benzene rings connected by an alkylene bridge and having one imino group on each ring, and in which each position ortho to an imino group bears a hydrocarbyl group.Type: ApplicationFiled: December 30, 2005Publication date: August 14, 2008Applicant: ALBEMARLE CORPORATIONInventors: John Y. Lee, Paul L. Wiggins, Judit Orgad, Mahmood Sabahi, Vernon O. Brandt, David W. Owens
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Patent number: 7399863Abstract: The invention provides novel ?2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with ?2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: September 21, 2004Date of Patent: July 15, 2008Assignee: Theravance, Inc.Inventors: Martin S. Linsell, John R. Jacobsen, Daisuke Roland Saito
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Publication number: 20080160348Abstract: This invention relates to electroluminescent benzofluorenes that are useful in electroluminescent applications. It also relates to electronic devices in which the active layer includes such a benzofluorene composition.Type: ApplicationFiled: December 20, 2007Publication date: July 3, 2008Inventor: ERIC MAURICE SMITH
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Publication number: 20080161325Abstract: The present invention relates to compounds of formula (AA) (I) and (X): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.Type: ApplicationFiled: November 13, 2007Publication date: July 3, 2008Inventors: Yvette M. Fobian, John N. Freskos, Barbara Jagodzinska
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Publication number: 20080124285Abstract: Described are merocyanine derivatives of formula (1a) or (1b) wherein n and o are integers from 2 to 4 and aminocyclohexenone intermediates. They are used in protecting human and animal hair and skin from UV radiation.Type: ApplicationFiled: December 8, 2004Publication date: May 29, 2008Inventors: Barbara Wagner, Thomas Ehlis, Stefan Muller
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Publication number: 20080021126Abstract: The invention relates to novel photoinitiators of formula (I) wherein each of the substituents is given the definition as set forth in the Specification and the claims. The photoinitiators can be used to prepare multifunctional photoinitiators.Type: ApplicationFiled: January 24, 2005Publication date: January 24, 2008Inventors: Kurt Dietliker, Rinaldo Husler, Jean-Luc Birbaum, Jean-Pierre Wolf
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Patent number: 7301053Abstract: An object of the present invention is to provide a modified cyclic aliphatic polyamine having a low viscosity and a small content of unreacted polyamine which can provide, when it is used as a curing agent for epoxy resin, an epoxy resin composition having an improved workability without adding solvent or diluent and an excellent property of epoxy resin cure product. The above modified cyclic aliphatic polyamine is obtained by addition reaction of a cyclic aliphatic polyamine such as isophoronediamine and norbornanediamine and an alkenyl compound such as styrene. The modified cyclic aliphatic polyamine thus obtained is added in epoxy resin to be used as a curing agent for epoxy resin.Type: GrantFiled: September 25, 2003Date of Patent: November 27, 2007Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Takeshi Koyama, Tetsushi Ichikawa, Hisayuki Kuwahara, Masatoshi Echigo
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Publication number: 20070255057Abstract: A method of nitrating a compound selected from the group consisting of is provided.Type: ApplicationFiled: February 27, 2007Publication date: November 1, 2007Inventors: Miall Cedilote, Thomas Patrick Cleary, Pingsheng Zhang
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Patent number: 7276518Abstract: Substituted cyclohexane-1,4-diamine compounds, methods for production thereof, pharmaceutical compositions comprising these compounds and methods of treatment using these compounds.Type: GrantFiled: November 10, 2003Date of Patent: October 2, 2007Assignee: Gruenenthal GmbHInventors: Bernd Sundermann, Hagen-Heinrich Hennies, Werner Englberger, Babette-Yvonne Koegel
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Patent number: 7230018Abstract: Substituted propane-1,3-diamine derivatives, methods for producing such derivatives, and medicaments and pharmaceutical compositions containing such derivatives useful for the treatment or prophylaxis of pain, urinary incontinence, itching, tinitus aurium, or diarrhea are provided.Type: GrantFiled: August 21, 2003Date of Patent: June 12, 2007Assignee: Gruenenthal GmbHInventors: Bernd Sundermann, Helmut Buschmann, Babette-Yvonne Koegel, Beatrix Merla, Nikolaus Risch
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Patent number: 7183435Abstract: The present invention relates to triphenylene compounds useful, for example, in an electrophotographic photoreceptor, and to a method for manufacturing these compounds.Type: GrantFiled: July 28, 2005Date of Patent: February 27, 2007Assignee: Ricoh Company, Ltd.Inventors: Yuuji Tanaka, Tomoyuki Shimada
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Self-assembled calixarene-based guest-host assemblies for guest storage by van der Waals confinement
Patent number: 7132571Abstract: A guest-host assembly having a generally spheroidal host assembly formed of trimers of calixarene molecules in a hexagonal close-packed assembly and its preparation. The calixarene trimers are associated together predominantly by van der Waals forces to provide dilated channels having void volumes within the range of 100-200 ?3. A guest component, such as hydrogen, methane, or another hydrocarbon or halocarbon, is encapsulated within the dilated channels of the spheroidal host assembly and retained within the channels primarily by van der Waals forces. The guest-host assembly is stable at a temperature of 150° C. or higher. The temperature at which the onset of the release of the guest component occurs is within the range of 150-300° C.Type: GrantFiled: May 9, 2002Date of Patent: November 7, 2006Assignee: The Curators of the University of MissouriInventors: Jerry L. Atwood, Leonard J. Barbour, Agoston Jerga -
Patent number: 7101911Abstract: Compounds of the formula I, in which M, A1, A2, K1 and K2 have the meanings given in the description are novel effective tryptase inhibitors.Type: GrantFiled: February 16, 2002Date of Patent: September 5, 2006Assignee: Altana Pharma AGInventor: Thomas Martin
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Patent number: 7074243Abstract: N-benzyl-m-phenylenediamine derivatives of general formula (I) or the physiologically tolerated, water-soluble salts thereof and dyeing agents for keratin fibers containing these compounds.Type: GrantFiled: February 2, 2002Date of Patent: July 11, 2006Assignee: WELLA AGInventors: Laurent Chassot, Hans-Juergen Braun
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Patent number: 6962964Abstract: This invention relates to improved polyepoxide resins cured with a mixture of methylene bridged poly(cycloaliphatic-aromatic)amines and a process for preparing such polyepoxide resins as well as to the methylene bridged poly(cycloaliphatic-aromatic)amine compositions and a method of making them. The improvement resides in using a curative (herein referred to as “Heavy MPCA”) comprised of the partially hydrogenated condensation product of formaldehyde and aniline or methyl substituted aniline containing a substantial amount (from 35 to 85% by weight, preferably 40 to 60% by weight) of oligomers in the form of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 and 15 aniline or methyl substituted aniline derivatives.Type: GrantFiled: February 6, 2003Date of Patent: November 8, 2005Assignee: Air Products and Chemicals, Inc.Inventors: Michael Ulman, Gamini Ananda Vedage, David Alan Dubowik, Stephen Michael Boyce
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Patent number: 6936077Abstract: 1,3-Diamino-4-(aminomethyl)-benzene derivatives of the general Formula (I) or their physiologically tolerated, water-soluble salts, as well as agents for the oxidative dyeing of fibers, containing these compounds.Type: GrantFiled: October 19, 2001Date of Patent: August 30, 2005Assignee: Wella AGInventors: Laurent Chassot, Hans-Juergen Braun
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Patent number: 6919482Abstract: Disclosed are multibinding compounds which are ?2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: January 30, 2004Date of Patent: July 19, 2005Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
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Patent number: 6914079Abstract: Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by ornithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.Type: GrantFiled: September 23, 2002Date of Patent: July 5, 2005Assignee: MediQuest Therapeutics, Inc.Inventors: Mark R. Burns, Gerard F. Graminski
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Patent number: 6906104Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.Type: GrantFiled: June 13, 2002Date of Patent: June 14, 2005Assignee: Pharmacia & Upjohn CompanyInventors: Heinrich Josef Schostarez, Robert Alan Chrusciel
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Patent number: 6872852Abstract: Cytotoxic polyamine analogues are provided that are useful for treating diseases where it is desired to inhibit cell growth and/or proliferation, for example cancer and post-angioplasty injury.Type: GrantFiled: March 23, 2001Date of Patent: March 29, 2005Assignee: MediQuest Therapeutics, Inc.Inventor: Mark R. Burns
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Patent number: 6806372Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R2SO4; R3 is selected from C1 to C2 alkyl or hydroxyethyl; R2 is selected from C1 to C22 alkyl and C1 to C22 mono and dihydroxyalkyl; and R is selected from of C1 to C16 alkyl, C1 to C10 hydroxyalkyl, C1 to C6 alkoxyalkyl and benzyl.Type: GrantFiled: April 1, 2003Date of Patent: October 19, 2004Assignee: The Procter & Gamble CompanyInventors: Mu-Ill Lim, Yuh-Guo Pan, Margaret Popp
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Patent number: 6800097Abstract: The oxidation hair dye precursor composition contains from 0.005 to 20.0 percent by weight of at least one coupler compound and from 0.005 to 20.0 percent by weight of at least one developer compound, which includes at least one substituted 2-aminoalkyl-1,4-diaminobenzene compound of the formula (I): New substituted 2-aminoalkyl-1,4-diaminobenzene compound of formula (I) are also described.Type: GrantFiled: May 15, 2002Date of Patent: October 5, 2004Assignee: Wella AktiengesellschaftInventors: Laurent Chassot, Hans-Juergen Braun
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Patent number: 6780998Abstract: The oxidation hair dye precursor composition contains from 0.005 to 20.0 percent by weight of one or more coupler compounds and from 0.005 to 20.0 percent by weight of one or more developer compounds. The one or more developer compounds include at least one substituted 2-aminoalkyl-1,4-diaminobenzene compound of the formula (I): New substituted 2-aminoalkyl-1,4-diaminobenzene compounds of formula (I) are described.Type: GrantFiled: April 17, 2002Date of Patent: August 24, 2004Assignee: Wella AktiengesellschaftInventors: Laurent Chassot, Hans-Juergen Braun
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Patent number: 6749644Abstract: The object of the present invention are colorants for oxidative dyeing of keratin fibers, particularly hair, based on a developer-coupler combination containing as the developer at least one 2-hydroxy-5-amino-biphenyl derivative of general formula (I), and novel 2-hydroxy-5-aminobiphenyl derivatives.Type: GrantFiled: January 30, 2002Date of Patent: June 15, 2004Assignee: Wella AktiengesellschaftInventors: Laurent Chassot, Hans-Juergen Braun
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Patent number: 6703526Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of formula (1): wherein X is selected from of halogen and R5SO4 R3 is selected from C1 to C2 alkyl and hydroxyethyl; and R, R1, R2 and R5 are each independently selected from C1 to C22 alkyl or C1 to C22 mono or dihydroxyalkyl.Type: GrantFiled: April 1, 2003Date of Patent: March 9, 2004Assignee: The Procter & Gamble CompanyInventors: Mu-Ill Lim, Yuh-Guo Pan, Margaret Popp
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Publication number: 20040034251Abstract: The present invention provides a process for producing a substituted aniline compound represented by the following general formula (6): 1Type: ApplicationFiled: August 11, 2003Publication date: February 19, 2004Inventors: Hidetaka Hiyoshi, Mahito Ogawa
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Patent number: 6664424Abstract: The present invention provides stereoscopically-pure diastereomers of Formula I: In a preferred embodiment, the stereoisomers of the present invention are of Formula II, depicted below: R2, R3 and R4 are independently H, OH, OCH3, CH2OH, NHCONH2, NH2, halogen or CF3, and R1 is pyridine, or an amine which may be substituted with hydrogen, lower alkyl, lower alkylenearyl, lower alkylenephenyl, lower alkylenehydroxyphenyl, lower alkyleneamine, lower alkyleneaminoaryl, lower alkylaminohydroxyphenyl, or a similar functional group. R5 is hydrogen, hydroxyl or methyl; R6 is hydrogen, lower alkyl, lower alkylenaryl, lower alkylenephenyl, lower alkylenehydroxyphenyl, lower alkyleneamine, lower alkyleneaminoaryl, lower alkylaminohydroxyphenyl, and the like. For both Formula I and Formual II, the first carbon on the side chain progressing from the ring is preferably in the R-configuration.Type: GrantFiled: March 25, 2002Date of Patent: December 16, 2003Assignee: Warner-Lambert CompanyInventors: Anthony Booth, James L. Caffrey
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Publication number: 20030145764Abstract: p-Diaminobenzene derivatives of general formula (I) or physiologically tolerated water-soluble salts thereof 1Type: ApplicationFiled: November 9, 2001Publication date: August 7, 2003Inventor: Laurent Chassot
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Patent number: 6589295Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of formula (1): wherein X is selected from of halogen and R5SO4 R3 is selected from C1 to C2 alkyl and hydroxyethyl; and R, R1, R2 and R5 are each independently selected from C1 to C22 alkyl or C1 to C22 mono or dihydroxyalkyl.Type: GrantFiled: November 16, 2001Date of Patent: July 8, 2003Assignee: Clairol IncorporatedInventors: Mu-Iii Lim, Yuh-Guo Pan, Margaret Popp
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Patent number: 6583246Abstract: The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.Type: GrantFiled: November 6, 2001Date of Patent: June 24, 2003Assignee: Bayer AktiengesellschaftInventors: Michael Grün, Thomas Knauf, Wilfried Braubach
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Publication number: 20030097004Abstract: There are disclosed compounds of the formula 1Type: ApplicationFiled: February 1, 2002Publication date: May 22, 2003Applicant: Schering CorporationInventors: Arthur G. Taveras, Cynthia J. Aki, Richard W. Bond, Jianping Chao, Michael Dwyer, Johan A. Ferreira, Jonathan A. Pachter, John J. Baldwin, Bernd Kaiser, Ge Li, J. Robert Merritt, Kingsley H. Nelson, Laura L. Rokosz
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Patent number: 6555959Abstract: A material for a light emitting device which is a compound represented by the following formula (I): wherein Ar1 and Ar6, which are the same or different, each represents a divalent aryl group or a divalent heterocyclic group; R2, R3, R7 and R8, which are the same or different, each represents an aryl group, a heterocyclic group or an aliphatic hydrocarbon group; R4a, R5a, R9a and R10a, which are the same or different, each represents a hydrogen atom or a monovalent group, and at least one of R4a, R5a, R9a and R10a represents an electron withdrawing group having a Hammett's &sgr;p value of 0.Type: GrantFiled: September 29, 2000Date of Patent: April 29, 2003Assignee: Fuji Photo Film Co., Ltd.Inventor: Kazumi Nii
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Publication number: 20030032802Abstract: This invention relates to the novel use of dianilino squarates in the treatment of disease states mediated by the chemokine, Interteukin-8 (IL-8).Type: ApplicationFiled: August 30, 2002Publication date: February 13, 2003Inventors: Michael R. Palovich, Joseph Weinstock, Katherine L. Widdowson
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Patent number: 6495546Abstract: Propanolamine derivatives represented by the following formula (I): These derivatives may be &bgr;3 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria activities. Pharmaceutical compositions containing such propanolamine derivatives, methods for the prevention and/or treatment diseases using these propanolamine derivatives, and processes for their preparation are also described.Type: GrantFiled: November 22, 2000Date of Patent: December 17, 2002Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Minoru Sakurai, Naoaki Fujii, Kumi Hosoi, Yasuyo Tomishima, Hisashi Takasugi, Hajime Sogabe, Hirofumi Ishikawa, Naomi Hanioka
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Publication number: 20020103238Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.Type: ApplicationFiled: March 12, 2002Publication date: August 1, 2002Inventors: Robert H. Chen, Min A. Xiang
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Patent number: 6395762Abstract: This invention provides compounds of Formula I having the structure wherein, R1, R2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.Type: GrantFiled: July 12, 2001Date of Patent: May 28, 2002Assignee: American Home Products CorporationInventors: William Floyd Fobare, Jill Freymuller
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Patent number: 6392097Abstract: Processes for the preparation of parylene dimers, and more particularly to processes for the preparation of derivatives of octafluoro-[2,2]paracylophane, otherwise known as AF4.Type: GrantFiled: March 20, 2001Date of Patent: May 21, 2002Assignee: Specialty Coating Systems, Inc.Inventors: William R. Dolbier, Jr., Jian-Xin Duan, Alex J. Roche
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Patent number: 6384031Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.Type: GrantFiled: March 9, 2001Date of Patent: May 7, 2002Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Robert H. Chen, Min A. Xiang
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Publication number: 20020007585Abstract: Sterically hindered N-substituted aryloxyamines are prepared by the transition-metal-catalyzed decomposition of diazonium salts in the presence of a sterically hindered nitroxyl radical. These compounds are useful as thermal and light stabilizers for a variety of organic substrates.Type: ApplicationFiled: April 2, 2001Publication date: January 24, 2002Inventors: Stephen D. Pastor, Sai Ping Shum
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Patent number: 6323243Abstract: The present invention provides compounds that block calcium channels and have the Formula I: and pharmaceutically acceptable salts, esters, and pro-drugs thereof, wherein R1 and R2 are independently H, phenylcyclopentylcarbonyl, C1-C7 alkyl, cyclohexylmethyl, benzyl, C1-C5 alkylbenzyl, or C1-C5 alkoxybenzyl, A is —C(O)— or —CH2—; R3 is H or —CH3; R4 is C1-C4 alkyl or piperidin-1-ylethyl; R5 is phenyl-(CH2)n—, C1-C4 alkylphenyl-(CH2)n—, or halophenyl-(CH2)n—; and n is 1 or 2. The present invention also provides pharmaceutical compositions containing the compounds of Formula I and methods of using them to treat stroke, cerebral ischemia, head trauma, and epilepsy.Type: GrantFiled: October 24, 2000Date of Patent: November 27, 2001Assignee: Warner-Lambert CompanyInventors: Michael Francis Rafferty, Yuntao Song
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Patent number: 6248785Abstract: This invention relates to novel compounds, pharmaceutical compositions comprising these compounds and their use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).Type: GrantFiled: January 22, 1999Date of Patent: June 19, 2001Assignee: SmithKline Beecham CorporationInventors: Katherine L. Widdowson, John Gerald Gleason
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Patent number: 6228130Abstract: 5-Nitroisatin is reacted with sodium hydroxide to produce an &agr;-keto acid sodium salt that is reduced with borane-tetrahydrofuran complex and then hydrogenated to produce 1-(2,5-diaminophenyl)ethylene glycol, a novel compound useful as a primary intermediate in the production of oxidative hair dyes.Type: GrantFiled: November 3, 1998Date of Patent: May 8, 2001Assignee: Bristol-Myers Squibb CompanyInventors: Mu-Ill Lim, Linas R. Stasaitis, Yuh-Guo Pan, Michael Y. M. Wong
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Patent number: 6191165Abstract: The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 30, 1997Date of Patent: February 20, 2001Assignee: Allelix Neuroscience Inc.Inventors: Vassil Iliya Ognyanov, Laurence A. Borden, Stanley Charles Bell, Jing Zhang