Amino Nitrogen And A Ring Bonded Directly To The Same Ring, And Any Other Amino Nitrogen In The Compound Is Bonded Directly To One Of The Rings Patents (Class 564/307)
  • Patent number: 9758731
    Abstract: The present invention discloses a process for the conversion of phenolics into aromatic hydrocarbons. In more detail, the present invention refers to a process for the selective hydrodeoxygenation of phenolic feeds into aromatic hydrocarbons, such as benzene, toluene, alkylbenzenes and others. The selective catalytic hydrodeoxygenation is performed in absence of external supply of molecular hydrogen.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: September 12, 2017
    Assignee: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Roberto Rinaldi, Xingyu Wang
  • Patent number: 9688604
    Abstract: The invention relates to a compound of formula (1) The invention further relates to Pd complexes comprising the compound according to the invention and to the use thereof in alkoxycarbonylation.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: June 27, 2017
    Assignee: EVONIK DEGUSSA GMBH
    Inventors: Reiko Jennerjahn, Samet Gülak, Xiangjie Fang, Kaiwu Dong, Helfried Neumann, Ralf Jackstell, Matthias Beller, Robert Franke, Dieter Hess, Katrin Marie Dyballa, Dirk Fridag, Frank Geilen
  • Patent number: 9469597
    Abstract: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and theft use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: October 18, 2016
    Assignee: Oryzon Genomics S.A.
    Inventors: Alberto Ortega Muñoz, Matthew Colin Thor Fyfe, Marc Martinell Pedemonte, María de los Ángeles Estiarte Martínez, Nuria Valls Vidal, Guido Kurz, Julio Cesar Castro Palomino Laria
  • Publication number: 20150133678
    Abstract: A compound containing a squaric acid or a croconic acid group as an anchoring group. The compound containing a squaric acid or a croconic acid group has formula 1: where n is 1 or 2, and D is selected from an alkyl, aryl, aralkyl, heteroalkyl, heteroaryl or heteroaralkyl substituent, and each substituent is substituted or unsubstituted.
    Type: Application
    Filed: April 8, 2013
    Publication date: May 14, 2015
    Applicant: SONY CORPORATION
    Inventors: Gerda Fuhrmann, David Danner, Markus Obermaier, Ameneh Bamedi Zilai, Gabriele Nelles, Lars Peter Scheller
  • Publication number: 20150119396
    Abstract: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and theft use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
    Type: Application
    Filed: October 22, 2012
    Publication date: April 30, 2015
    Inventors: Alberto Ortega Muñoz, Matthew Colin Thor Fyfe, Marc Martinell Pedemonte, Maria de los Angeles Estiarte Martínez, Nuria Valls Vidal, Guido Kurz, Julio Cesar Castro Palomino Laria
  • Publication number: 20150065487
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: November 11, 2014
    Publication date: March 5, 2015
    Inventors: Sara Hadida-Ruah, Anna Hazlewood, Peter Grootenhuis, Fred Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
  • Publication number: 20150031722
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 29, 2015
    Inventors: Sara Hadida-Ruah, Anna Hazlewood, Peter Grootenhuis, Fredrick Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
  • Patent number: 8937300
    Abstract: This invention relates to triarylamine compounds that are useful in electronic applications. It also relates to electronic devices in which the active layer includes such a compound.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: January 20, 2015
    Assignee: E I du Pont de Nemours and Company
    Inventors: Ying Wang, Weishi Wu, Kerwin D. Dobbs
  • Publication number: 20140357634
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: August 14, 2014
    Publication date: December 4, 2014
    Applicant: GRÜNENTHAL GMBH
    Inventors: BERT NOLTE, WOLFGANG SCHRÖDER, KLAUS LINZ, WERNER ENGLBERGER, HANS SCHICK, HEINZ GRAUBAUM, BIRGIT ROLOFF, SIGRID OZEGOWSKI, JÓZSEF BÁLINT, HELMUT SONNENSCHEIN
  • Publication number: 20140350301
    Abstract: Provided herein are novel processes for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. Provided further herein are novel acid addition salts of trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine, and process for their preparation. The intermediate and its acid addition salts are useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Application
    Filed: June 6, 2014
    Publication date: November 27, 2014
    Inventors: Anil Shahaji KHILE, Vignesh NAIR, Nikhil TRIVEDI, Nitin Sharadchandra PRADHAN
  • Publication number: 20140350141
    Abstract: The invention relates to a hydrophilically modified multifunctional amine AC which has more than one primary ammo group per molecule, and at least one group per molecule derived from the reaction of an epoxide group with a reactive group selected from the group consisting of secondary amino groups >NH, hydroxyl groups —OH, mercaptan groups —SH, amide groups —CO—NHR, where R can be hydrogen or an alkyl group having from one to twelve carbon atoms, hydroxyester groups, and acid particularly carboxyl groups —COOH, sulphonic acid groups —SO3H, and phosphonic acid groups —PO3H2, and preferably, also moieties which are compatible with an epoxy resin, as well as a process for its preparation, and a method of use thereof.
    Type: Application
    Filed: May 3, 2012
    Publication date: November 27, 2014
    Applicant: ALLNEX AUSTRIA GMBH
    Inventors: Florian Lunzer, Rudolf Schipfer, Günther Monschein, Ursula Meisner, Albine Kernbichler
  • Publication number: 20140323727
    Abstract: Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Application
    Filed: July 1, 2014
    Publication date: October 30, 2014
    Inventors: Anil Shahaji Khile, Jayesh Patel, Nikhil Trivedi, Nitin Sharadchandra Pradhan
  • Publication number: 20140312287
    Abstract: The invention relates to arylamino compounds and to the use thereof in electronic devices, for example organic electroluminescent devices. The invention furthermore relates to electronic devices comprising one or more of the said compounds, for example as hole-transport materials in a corresponding functional layer of the device. The invention furthermore relates to a process for the preparation of the said compounds, and to a formulation comprising one or more of the said compounds.
    Type: Application
    Filed: November 15, 2012
    Publication date: October 23, 2014
    Applicant: Merck Patent GmbH
    Inventors: Philipp Stoessel, Frank Voges, Arne Buesing, Christof Pflumm, Teresa Mujica-Fernaud, Christian Wirges
  • Patent number: 8853455
    Abstract: The present invention relates to a process for preparing substituted 2-nitrobiphenyls and to specific 2-nitrobiphenyls. The invention further relates to a process for preparing 2-aminobiphenyls from such 2-nitrobiphenyls and to a process for preparing (het)arylamides of such 2-aminobiphenyls.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: October 7, 2014
    Assignee: BASF SE
    Inventors: Alexander Korte, Jan Klaas Lohmann, Thomas Grote, Klaus Ebel, Thomas Zierke, Horst Mayer, Ralf Wazulek
  • Publication number: 20140296241
    Abstract: The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.
    Type: Application
    Filed: October 15, 2012
    Publication date: October 2, 2014
    Inventors: Irving W. Wainer, Ruin Moaddel, Michel Bernier, Carlos A. Zarate, Marc C. Torjman, Michael E. Goldberg, Mary J. Tanga
  • Patent number: 8846765
    Abstract: A pharmaceutical combination comprising as components (a) at least one 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol compound, and (b) at least one NMDA-antagonist, a pharmaceutical formulation and a dosage form comprising such a combination, and a method of treating pain, e.g. inflammatory pain or neuropathic pain, in which components (a) and (b) are administered simultaneously or sequentially to a mammal, with component (a) being administered either before or after component (b), and with components (a) or (b) being administered to the mammal either via the same pathway of administration or via different pathways of administration.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: September 30, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Klaus Schiene, Petra Bloms-Funke
  • Publication number: 20140256729
    Abstract: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and theft use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
    Type: Application
    Filed: October 22, 2012
    Publication date: September 11, 2014
    Inventors: Alberto Ortega Muñoz, Matthew Colin Thor Fyfe, Marc Martinell Pedemonte, Maria de los Ángeles Estiarte Martínez, Nuria Valls Vidal, Guido Kurz, Julio Cesar Castro Palomino Laria
  • Patent number: 8829243
    Abstract: A method for removing methylene-bridged polyphenyl polyamines from an aqueous stream comprising said methylene-bridged polyphenyl polyamines according to the invention comprises the steps of Providing a pertraction equipment comprising a membrane with a first side and a second side opposite to said first side; Bringing an aqueous stream comprising methylene-bridged polyphenyl polyamines into contact with the first side of the membrane and bringing an organic stream into contact with the second side of the membrane, thereby causing the methylene-bridged polyphenyl polyamines to transfer from the aqueous stream through the membrane to the organic stream. The method further comprises, before bringing the aqueous stream and organic stream in contact with the membrane, the step of wetting the membrane with a liquid having a surface tension of less than 40 mN/m.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: September 9, 2014
    Assignee: Huntsman International LLC
    Inventors: Rabah Mouazer, Johannes Lodewijk Koole, Ramon Scheffer
  • Publication number: 20140221473
    Abstract: Embodiments of the present disclosure provide compositions including ketamine analogues, salts, and disalts, pharmaceutical compositions including ketamine analogues, salts, or disalts, methods of treatment of a condition or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Application
    Filed: June 29, 2012
    Publication date: August 7, 2014
    Inventors: Jahanshah Amin, Kirpal S. Bisht, Meghanath Gali
  • Patent number: 8791301
    Abstract: Disclosed is a novel method of preparing a secondary amine compound using a microflow reactor. According to the method, a primary amine compound and a halide compound are allowed to react with each other in the microflow reactor, such that the production of a tertiary amine compound or an ammonium salt is minimized, whereby the secondary amine compound is efficiently prepared.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: July 29, 2014
    Assignee: University-Industry Cooperation Group of Kyunghee University
    Inventors: Jin-Hyun Jeong, Han-Seo Moon, Liu-Lan Shen, Yong-Sung Choi
  • Publication number: 20140187556
    Abstract: Anti-amyloid compounds are provided along with methods of use thereof.
    Type: Application
    Filed: March 2, 2012
    Publication date: July 3, 2014
    Applicant: Treventis Corporation
    Inventors: Mark A. Reed, Arun Yadav, Scott C. Banfield, Christopher J. Barden
  • Publication number: 20140179014
    Abstract: Nitric oxide probes including a compound represented by Formula, I, II, III, IV, V, VI or a combination thereof are provided. Methods of using these nitric oxide probes to detect nitric oxide are also provided.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Inventors: Eric V. Anslyn, Youjun Yang, Michelle M. Adams
  • Patent number: 8741960
    Abstract: The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein Y, L, A, W1, W2, and R?1 are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: June 3, 2014
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Shoujun Chen, Lijun Sun, Yu Xie
  • Publication number: 20140148571
    Abstract: Disclosed are a diamine represented by the following formula, a polyimide and a polyamide using the same as the raw material, a cyclized product thereof, and a method for producing the same. In the formula, A represents a single bond, an ether bond, a sulfide bond, CO, CH2, SO, SO2, C(CH3)2, NHCO or C(CF3)2, or a bivalent group having an aliphatic ring, a hetero ring or an aromatic ring, R1 represents a C1-4alkyl group or a halogen group, and each of “a” and “b” independently represents an integer of 0-2, and 1?a+b?4. The polyimide and the polyamide are a fluorescent polyimide and a fluorescent polyamide that are easily soluble in organic solvents to the extent that they can be formed into a film by a wet process when making an optical device, that have heat resistance and strength when formed into a film, and that have superior fluorescent characteristics.
    Type: Application
    Filed: April 23, 2013
    Publication date: May 29, 2014
    Applicant: Central Glass Company, Limited
    Inventor: Central Glass Company, Limited
  • Publication number: 20140138628
    Abstract: Fluoroacyl arylamines are disclosed for use in an electronic applications, such as, in photoresponsive and electroresponsive devices.
    Type: Application
    Filed: November 21, 2012
    Publication date: May 22, 2014
    Applicant: XEROX CORPORATION
    Inventors: Adrien P. Cote, Richard A. Klenkler, Amanda L. Bongers, Gregory M. McGuire
  • Patent number: 8722939
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: May 13, 2014
    Assignees: Northwestern University, Cambria Pharmaceuticals, Inc.
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Patent number: 8710266
    Abstract: Disclosed are compounds represented by structural formula (I): methods of producing compounds represented by structural formula (I). and their use in inhibiting oxidation in an oxidizable material.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: April 29, 2014
    Assignee: Polnox Corporation
    Inventors: Rajesh Kumar, Suizhou Yang, Vijayendra Kumar, Ashok L. Cholli
  • Publication number: 20140091256
    Abstract: The present invention describes chemical systems and methods for reducing C—O, C—N, and C—S bonds, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said system optionally comprising at least one molecular hydrogen donor compound, molecular hydrogen, or both.
    Type: Application
    Filed: October 2, 2013
    Publication date: April 3, 2014
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: ROBERT H. GRUBBS, ALEXEY FEDOROV, ANTON TOUTOV, NICHOLAS A. SWISHER
  • Publication number: 20140058101
    Abstract: The invention is directed to a phosphine compound represented by general formula (1) wherein R? and R? independently are selected from alkyl, cycloalkyl and 2-furyl radicals, or R? and R? are joined together to form with the phosphorous atom a carbon-phosphorous monocycle comprising at least 3 carbon atoms or a carbon-phosphorous bicycle; the alkyl radicals, cycloalkyl radicals, and carbon-phosphorous monocycle being unsubstituted or substituted by at least one radical selected from the group of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals; Cps is a partially substituted or completely substituted cyclopentadien-1-yl group, including substitutions resulting in a fused ring system, and wherein a substitution at the 1-position of the cyclopentadien-1-yl group is mandatory when the cyclopentadien-1-yl group is not part of a fused ring system or is part of an indenyl group. Also claimed is the use of these phosphines as ligands in catalytic reactions and the preparation of these phosphines.
    Type: Application
    Filed: October 29, 2013
    Publication date: February 27, 2014
    Applicant: Evonik Degussa GmbH
    Inventors: Herbert Plenio, Christoph Fleckenstein, Renat Kadyrov, Juan Almena, Axel Monsees, Thomas Riermeier
  • Patent number: 8658827
    Abstract: A method of synthesizing a substituted aminocyclohexanone compound comprising reacting a compound of formula (II) with an organolithium compound to form a compound of formula (III)
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: February 25, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Pruehs, Carsten Griebel, Marita Mueller
  • Publication number: 20140039181
    Abstract: The invention relates to a method for producing a N-substituted amine compound by catalyzed alkylation. The method uses amine and alcohol or two kinds of amines as the reaction materials, employs composite metal oxides catalyst at a reaction temperature of 80-180° C. to catalyze the reaction for 6-36 hours, so as to produce the N-substituted amine compound. The reaction condition of the method of the invention is relatively moderate, using a catalyst made of cheap non-noble metals, which is non-caustic and easy to be separated and reused. The reaction does not need any medium and has relatively high conversion rate and selectivity.
    Type: Application
    Filed: December 28, 2012
    Publication date: February 6, 2014
    Applicant: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
    Inventor: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
  • Patent number: 8637707
    Abstract: The present invention relates to a process for preparing substituted 2-aminobiphenyls and to a process for preparing (Het)arylamides of such 2-aminobiphenyls.
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: January 28, 2014
    Assignees: BASF SE, Technische Universitaet Muenchen
    Inventors: Michael Keil, Michael Rack, Thomas Zierke, Markus Heinrich, Alexander Wetzel
  • Patent number: 8637168
    Abstract: The present invention relates to aromatic amines and to electronic devices in which these amines are used, in particular, as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: January 28, 2014
    Assignee: Merck Patent GmbH
    Inventors: Philipp Stoessel, Holger Heil, Dominik Joosten, Christof Pflumm, Anja Gerhard
  • Publication number: 20130324745
    Abstract: A process is provided which allows the synthesis of a large number of styrene derivatives with formation of C—C bonds, with use being possible of economically advantageous substrates, readily available carbon nucleophiles, and both inexpensive and environmentally unproblematic catalyst systems, permitting reaction under mild conditions and a high compatibility with functional groups on the reactants involved.
    Type: Application
    Filed: May 31, 2013
    Publication date: December 5, 2013
    Inventors: Matthias GOTTA, Bernd Wilhelm LEHNEMANN, Axel VON WANGELIN JACOBI, Samet GUELAK
  • Publication number: 20130324763
    Abstract: A process for the synthesis of chiral propargylic alcohols.
    Type: Application
    Filed: October 14, 2011
    Publication date: December 5, 2013
    Applicant: LONZA LTD
    Inventors: Meinrad Brenner, Erick M. Carreira, Nicka Chinkov, Miriam Lorenzi, Aleksander Warm, Lothar Zimmermann
  • Publication number: 20130302903
    Abstract: Nitric oxide probes comprising a compound represented by Formula, I, II, III, IV, V, VI or a combination thereof are provided. Methods of using these nitric oxide probes to detect nitric oxide are also provided.
    Type: Application
    Filed: October 4, 2012
    Publication date: November 14, 2013
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Eric V. Anslyn, Youjun Yang, Michelle M. Adams
  • Patent number: 8581006
    Abstract: Reaction of a carboxylic acid-containing polymer with certain aromatic amines and polyols results in ester containing dispersant viscosity modifiers with improved soot handling performance in heavy-duty diesel engines, compared with non-ester containing dispersants.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: November 12, 2013
    Assignee: The Lubrizol Corporation
    Inventors: Matthew D. Gieselman, John K. Pudelski, Renee A. Eveland, Adam J. Preston
  • Publication number: 20130267536
    Abstract: The present invention relates to novel substituted methyl-amines, serotonin 5-HT6 receptor antagonists, to active components, pharmaceutical compositions, method for prophylaxis and treatment of CNS diseases and “molecular tools”, in which novel substituted methyl-amines represent compounds of the general formula 1 and their crystalline forms and pharmaceutically acceptable salts, wherein: W represents benzene, naphthalene, indolizine, quinoline or oxazole cycle; R1=H, F, Cl; R2 represents hydrogen, fluoro, methyl, phenyl, thienyl, furan-2-yl, pyridyl, piperazin-1-yl or 4-methylpiperazin-1-yl; R3 represents cyclopropyl or optionally substituted methyl; with the exception of the compounds in which W simultaneously represents oxazole cycle and R2=phenyl or pyridyl.
    Type: Application
    Filed: December 13, 2011
    Publication date: October 10, 2013
    Applicant: ALLA CHEM, LLC
    Inventors: Alexandre Vasilievich Ivachtchenko, Oleg Dmitrievich Mitkin, Madina Georgievna Kadieva
  • Publication number: 20130236573
    Abstract: The present invention is directed to methods for the treatment of treatment-refractory depression or treatment-resistant depression comprising administering to a patient in need thereof, a therapeutically effective amount of esketamine as mono-therapy or as combination therapy with at least on antidepressant.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 12, 2013
    Inventors: Jaskaran Singh, Ivo Caers
  • Publication number: 20130211106
    Abstract: Microwave irradiation is used to synthesize graphene and metallic nanocatalysts supported on graphene either by solid or solution phase. In solid phase methods, no solvents or additional reducing agents are required so the methods are “environmentally friendly” and economical, and the graphene and nanocatalysts are substantially free of residual contaminants. Recyclable, high efficiency Pd nanocatylysts are prepared by these methods.
    Type: Application
    Filed: March 25, 2011
    Publication date: August 15, 2013
    Inventors: M. Samy El-Shall, Victor Abdelsayed, Hassan M.A. Hassan, Abd EI Rahman S. Khder, Khaled M. Abouzeid, Qilin Dai, Parichehr Afshani, Frank Gupton, Ali R. Siamaki, Zeid Abdullah M. Alothman, Hamad Zaid Alkhathlan
  • Publication number: 20130197095
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 1, 2013
    Applicant: Grünenthal GmbH
    Inventor: Grünenthal GmbH
  • Publication number: 20130197041
    Abstract: The present invention provides a method of selection of a patient, who is a candidate for treatment with an NMDA antagonist drug, such as (S)-1-phenyl-2-(pyridin-2-yl)ethanamine or ketamine, whereby to predict an increased or decreased likelihood of response to the NMDA antagonist. The invention provides a method for determining the sequence of GABR-A2 at any of four single nucleotide polymorphism (SNP) sites known as rs3756007, rs11503016, rs17537359 or rs1372472. The method also provides ARMS primers optimised for determining the sequence at these GABR-A2 SNPs and diagnostic kits comprising suitable primers or probes for determining the particular SNPs.
    Type: Application
    Filed: December 14, 2012
    Publication date: August 1, 2013
    Applicant: ASTRAZENECA AB
    Inventor: AstraZeneca AB
  • Publication number: 20130190407
    Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
    Type: Application
    Filed: December 28, 2012
    Publication date: July 25, 2013
    Applicant: NPS Pharmaceuticals, Inc.
    Inventor: NPS Pharmaceuticals, Inc.
  • Patent number: 8492558
    Abstract: The present invention relates to a process for preparing 2-aminobiphenyls of the formula I in which n is 0, 1, 2 or 3, R1 is hydrogen, cyano or fluorine, and each R2 is independently selected from cyano, fluorine, C1-C4-alkyl, C1-C4-fluoroalkyl, C1-C4-alkoxy, C1-C4-fluoroalkoxy, C1-C4-alkylthio and C1-C4-fluoroalkylthio. The invention also relates to a process for preparing pyrazolecarboxamides of such 2-aminobiphenyls.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: July 23, 2013
    Assignee: BASF SE
    Inventors: Thomas Zierke, Volker Maywald, Sebastian Peer Smidt
  • Publication number: 20130182202
    Abstract: The present invention relates to liquid-crystalline media (LC media) having negative or positive dielectric anisotropy comprising self-aligning mesogens (SAMs) which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). The invention therefore also encompasses LC displays having homeotropic alignment of the liquid-crystalline medium (LC medium) without conventional imide alignment layers. The LC media may be supplemented by a polymerisable or polymerised component, which serves for stabilisation of the alignment, for adjustment of the tilt angle and/or as passivation layer.
    Type: Application
    Filed: August 29, 2011
    Publication date: July 18, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Archetti Graziano, Andreas Taugerbeck
  • Patent number: 8486594
    Abstract: An object of the invention is to provide: a p-terphenyl compound mixture useful as a charge-transporting agent which has improved solubility in organic solvents to thereby diminish a cracking phenomenon, which poses problems concerning photoreceptor characteristics, and can realize an electrophotographic photoreceptor having high sensitivity and high durability; and an electrophotographic photoreceptor employing the compound mixture. The invention relates to: a p-terphenyl compound mixture which includes two symmetric p-terphenyl compounds respectively represented by the following general formula (1) and general formula (2) and an asymmetric p-terphenyl compound represented by the following general formula (3) which has both a group of substituents of the compound represented by general formula (1) and a group of substituents of the compound represented by general formula (2); and an electrophotographic photoreceptor containing the compound mixture.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: July 16, 2013
    Assignee: Hodogaya Chemical Co., Ltd.
    Inventors: Shinya Nagai, Atsushi Takesue, Makoto Koike, Katsumi Abe, Takehiro Nakajima
  • Patent number: 8476474
    Abstract: Disclosed are asymmetric styryl derivatives and an organic light emitting diode prepared using the same. More particularly, there are provided asymmetric styryl derivatives that can provide a blue organic light emitting diode with superior thermal stability, as well as improved luminous efficiency, improved brightness, and extended lifetime, by synthesizing a novel thermally stable compound with a styryl structure represented by Formula 1, and using the compound as a dopant in an organic light emitting layer (EML) of a multilayered organic light emitting diode, and an organic light emitting diode prepared by the same.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: July 2, 2013
    Assignee: Doosan Corporation
    Inventors: Tae-Hyung Kim, Jin-Seok Hong, Kyoung-Soo Kim, Sang-Do Lee
  • Publication number: 20130165696
    Abstract: Provided herein are novel processes for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. Provided further herein are novel acid addition salts of trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine, and process for their preparation. The intermediate and its acid addition salts are useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Application
    Filed: June 28, 2011
    Publication date: June 27, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Anil Shahaji Khile, Vignesh Nair, Nikhil Trivedi, Nitin Sharadchandra Pradhan
  • Publication number: 20130150577
    Abstract: Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.
    Type: Application
    Filed: April 19, 2011
    Publication date: June 13, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Anil Shahaji Khile, Jayesh Patel, Nikhil Trivedi, Nitin Sharadchandra Pradhan
  • Publication number: 20130109751
    Abstract: The present invention relates to the use of LSD-1 enzyme inhibitors in the osteogenic differentiation of cells capable to differentiate into osteoblasts, especially mesenchymal stem cells, adult stem cells, and cells with osteogenic potential
    Type: Application
    Filed: October 24, 2012
    Publication date: May 2, 2013
    Applicant: MESOGENICS S.R.L.
    Inventor: MESOGENICS S.R.L.