Amino Nitrogen And A Ring Bonded Directly To The Same Ring, And Any Other Amino Nitrogen In The Compound Is Bonded Directly To One Of The Rings Patents (Class 564/307)
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Patent number: 8476474Abstract: Disclosed are asymmetric styryl derivatives and an organic light emitting diode prepared using the same. More particularly, there are provided asymmetric styryl derivatives that can provide a blue organic light emitting diode with superior thermal stability, as well as improved luminous efficiency, improved brightness, and extended lifetime, by synthesizing a novel thermally stable compound with a styryl structure represented by Formula 1, and using the compound as a dopant in an organic light emitting layer (EML) of a multilayered organic light emitting diode, and an organic light emitting diode prepared by the same.Type: GrantFiled: January 25, 2008Date of Patent: July 2, 2013Assignee: Doosan CorporationInventors: Tae-Hyung Kim, Jin-Seok Hong, Kyoung-Soo Kim, Sang-Do Lee
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Publication number: 20130165696Abstract: Provided herein are novel processes for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. Provided further herein are novel acid addition salts of trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine, and process for their preparation. The intermediate and its acid addition salts are useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.Type: ApplicationFiled: June 28, 2011Publication date: June 27, 2013Applicant: ACTAVIS GROUP PTC EHFInventors: Anil Shahaji Khile, Vignesh Nair, Nikhil Trivedi, Nitin Sharadchandra Pradhan
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Publication number: 20130150577Abstract: Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.Type: ApplicationFiled: April 19, 2011Publication date: June 13, 2013Applicant: ACTAVIS GROUP PTC EHFInventors: Anil Shahaji Khile, Jayesh Patel, Nikhil Trivedi, Nitin Sharadchandra Pradhan
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Publication number: 20130109751Abstract: The present invention relates to the use of LSD-1 enzyme inhibitors in the osteogenic differentiation of cells capable to differentiate into osteoblasts, especially mesenchymal stem cells, adult stem cells, and cells with osteogenic potentialType: ApplicationFiled: October 24, 2012Publication date: May 2, 2013Applicant: MESOGENICS S.R.L.Inventor: MESOGENICS S.R.L.
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Patent number: 8426646Abstract: The present invention relates to a process for the preparation of compounds of formula (I) wherein R1 is C6-C7 alkyl or a group (A1) wherein R2, R3 and R4 are each independently of the others hydrogen or C1-C4 alkyl; wherein a compound of formula (II) wherein R1 is as defined for formula (I) and X is bromine or chlorine, is reacted with urea in the presence of a base and a catalytic amount of at least one palladium complex compound, wherein the palladium complex compound comprises at least one ferrocenyl-biphosphine ligand.Type: GrantFiled: June 30, 2008Date of Patent: April 23, 2013Assignee: Syngenta Crop Protection LLCInventors: Maren Fuerst, Thomas Vettiger
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Publication number: 20130096175Abstract: Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.Type: ApplicationFiled: November 17, 2010Publication date: April 18, 2013Applicants: SOUTHERN RESEARCH INSTITUTE, UNIVERSITY OF ROCHESTERInventors: David S. Goldfarb, Joseph A. Maddry, Lynn Rasmussen, Ellie Lucile White, Krister Wennerberg
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Publication number: 20130079559Abstract: A sulfur-containing palladium-carbon catalyst prepared by loading palladium on an active carbon, mixing the palladium-carbon catalyst with a solvent to form a slurry, adding a sulfide to the slurry to treat the loaded palladium under a predetermined temperature, and removing liquid and drying to obtain the catalyst. The sulfur-containing palladium-carbon catalyst is suitable for making phenylene diamine rubber antioxidant with improved productivity and selectivity.Type: ApplicationFiled: July 13, 2012Publication date: March 28, 2013Applicant: Jiangsu Sinorgchem Technology Co., Ltd.Inventors: Xiaonian LI, Qunfeng Zhang, Xinmin Chen, Feng Feng, Lei Ma, Chunshan Lu, Chunsheng Li
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Patent number: 8389580Abstract: Described herein are arylcyclopropylamine compounds that may inhibit enzymes comprising an amine oxidase domain, such as LSD1, MAO A and/or MAO B.Type: GrantFiled: June 2, 2010Date of Patent: March 5, 2013Assignee: Duke UniversityInventors: Dewey G. McCafferty, Julie Pollock
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Publication number: 20130052572Abstract: Provided is a compound represented by the following Formula (I): wherein in Formula (I), F represents a charge transporting skeleton, L represents a divalent linking group including a —(CH2)n—O— group, m represents an integer of from 1 to 8, and n represents an integer of from 3 to 6.Type: ApplicationFiled: March 5, 2012Publication date: February 28, 2013Applicant: FUJI XEROX CO., LTD.Inventors: Katsumi NUKADA, Wataru YAMADA, Tomoya SASAKI, Yuko IWADATE, Kenji KAJIWARA
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Patent number: 8334060Abstract: A triarylamine-based compound of formula 1, a method of preparing the same, and an organic light emitting device including the triarylamine-based compound of formula 1: where Ar1 through Ar4 are independently a substituted or unsubstituted C6-C30 aryl group or a substituted or unsubstituted C2-C30 heterocyclic group; R is a halogen atom, a cyano group, a substituted or unsubstituted C1-C30 alkyl group; n is an integer of 1 through 3; and m is an integer of 1 through 3. The triarylamine-based compound of formula 1 has excellent electrical properties and a great charge transporting capability. An organic light emitting device including an organic layer formed of the triarylamine-based compound has high efficiency, low operating voltage, great luminance, and long lifetime.Type: GrantFiled: May 1, 2009Date of Patent: December 18, 2012Assignee: Samsung Display Co., Ltd.Inventors: Seok-Hwan Hwang, Young-Kook Kim, Chang-Ho Lee, Seok-Jong Lee, Seung-Gak Yang, Hee-Yeon Kim, Jung-Han Shin
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Patent number: 8329676Abstract: The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type, which alter lymphocyte trafficking. The compounds of the invention include compounds having a phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.Type: GrantFiled: July 12, 2010Date of Patent: December 11, 2012Assignee: University of Virginia Patent FoundationInventors: Kevin R. Lynch, Timothy L. Macdonald
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Publication number: 20120277185Abstract: To provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Carboxamides represented by the following Formula (I) and use thereof as pesticides and an animal parasite control agent: wherein each substituent is as defined in the specification.Type: ApplicationFiled: July 10, 2010Publication date: November 1, 2012Applicant: BAYER CROPSCIENDE AGInventors: Jun Mihara, Koichi Araki, Takuma Mori, Tetsuya Murata, Yasushi Yoneta, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya, Ulrich Görgens
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Publication number: 20120264765Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.Type: ApplicationFiled: October 29, 2010Publication date: October 18, 2012Applicants: Cambria Pharmaceuticals, Inc., Northwestern UniversityInventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanties, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
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Publication number: 20120184775Abstract: A method for removing methylene-bridged polyphenyl polyamines from an aqueous stream comprising said methylene-bridged polyphenyl polyamines according to the invention comprises the steps of Providing a pertraction equipment comprising a membrane with a first side and a second side opposite to said first side; Bringing an aqueous stream comprising methylene-bridged polyphenyl polyamines into contact with the first side of the membrane and bringing an organic stream into contact with the second side of the membrane, thereby causing the methylene-bridged polyphenyl polyamines to transfer from the aqueous stream through the membrane to the organic stream. The method further comprises, before bringing the aqueous stream and organic stream in contact with the membrane, the step of wetting the membrane with a liquid having a surface tension of less than 40 mN/m.Type: ApplicationFiled: July 22, 2010Publication date: July 19, 2012Applicant: HUNTSMAN INTERNATIONAL LLCInventors: Rabah Mouazer, Johannes Lodewijk Koole, Ramon Scheffer
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Publication number: 20120149914Abstract: A method of synthesizing a substituted aminocyclohexanone compound comprising reacting a compound of formula (II) with an organolithium compound to form a compound of formula (III)Type: ApplicationFiled: December 7, 2011Publication date: June 14, 2012Applicant: Gruenenthal GmbHInventors: Stefan PRUEHS, Carsten GRIEBEL, Marita MUELLER
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Patent number: 8197722Abstract: Compositions capable of simultaneous two-photon absorption and higher order absorptivities are provided. Compounds having a donor-pi-donor or acceptor-pi-acceptor structure are of particular interest, where the donor is an electron donating group, acceptor is an electron accepting group, and pi is a pi bridge linking the donor and/or acceptor groups. The pi bridge may additionally be substituted with electron donating or withdrawing groups to alter the absorptive wavelength of the structure. Also disclosed are methods of generating an excited state of such compounds through optical stimulation with light using simultaneous absorption of photons of energies individually insufficient to achieve an excited state of the compound, but capable of doing so upon simultaneous absorption of two or more such photons. Applications employing such methods are also provided, including controlled polymerization achieved through focusing of the light source(s) used.Type: GrantFiled: July 30, 2001Date of Patent: June 12, 2012Assignee: The California Institute of TechnologyInventors: Seth Marder, Joseph Perry
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Publication number: 20120130097Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.Type: ApplicationFiled: January 30, 2012Publication date: May 24, 2012Applicant: AstraZeneca ABInventors: Adrian Clark, Elfyn Jones, Ulf Larsson, Anna Minidis
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Publication number: 20120129926Abstract: The invention relates to novel calcium-sensing receptor (CaSR) modulating trifluoromethylphenylene cyclopentylene compounds represented in formula (I) and derivatives thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.Type: ApplicationFiled: May 26, 2010Publication date: May 24, 2012Applicant: LEO PHARMA A/SInventor: Bjarne Nørremark
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Publication number: 20120122784Abstract: The invention relates to novel calcium-sensing receptor (CaSR) modulating substituted cyclopentylene compounds represented in formula I and derivatives thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.Type: ApplicationFiled: May 26, 2010Publication date: May 17, 2012Applicant: LEO PHARMA A/SInventors: Bjarne Nørremark, Lars Kristian Albert Blæhr, Anne Eeg Knapp, Kristoffer Månsson
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Publication number: 20120082835Abstract: A structured organic film comprising a plurality of segments and a plurality of linkers arranged as a covalent organic framework, wherein the structured organic film may be a multi-segment thick structured organic film.Type: ApplicationFiled: December 9, 2011Publication date: April 5, 2012Applicant: XEROX CORPORATIONInventors: Matthew A. HEUFT, Adrien Pierre CÔTÉ, Kathy L. De Jong
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Publication number: 20120065426Abstract: The present invention aims to provide a practical process for preparing amine compounds through a generalized highly-diastereoselective reductive amination reaction.Type: ApplicationFiled: September 14, 2011Publication date: March 15, 2012Applicant: Kanto Kagaku Kabushiki KaishaInventors: Masahito Watanabe, Kouichi Tanaka, Takashi Miki, Kunihiko Murata
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Publication number: 20120059191Abstract: There is provided a substance having much higher catalytic activity for a Suzuki-Miyaura coupling reaction than conventional heterogenous catalysts. The present invention provides a zeolite-palladium complex including USY-zeolite and Pd supported on the USY-zeolite, the Pd having a Pd—Pd coordination number of 4 or less and an oxidation number of 0.5 or less.Type: ApplicationFiled: February 23, 2010Publication date: March 8, 2012Inventors: Kazu Okumura, Miki Niwa, Hirosuke Matsui, Yoshinori Enmi, Takuya Tomiyama, Shizuyo Okuda
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Publication number: 20120043533Abstract: An aromatic amine derivative represented by the following formula (1): wherein A1 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heterocyclic group or an organic group represented by the following formula (2): wherein X1, X2 and X3 are independently a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group; X1 and X2 are linkage groups which are different from each other; and B1, B2 and B3 are independently a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group.Type: ApplicationFiled: April 22, 2010Publication date: February 23, 2012Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Yumiko Mizuki, Masakazu Funahashi
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Publication number: 20120046471Abstract: This invention relates to a process for preparing functionalized aryl, heteroaryl, cycloalkenyl, or alkenyl compounds, by a transition-metal-catalyzed cross-coupling reaction of a substituted or unsubstituted aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide, where X is a halide, diazonium, tosylate (p-toluenesulphonate), mesylate (methanesulphonate) or triflate (trifluoromethanesulphonate) leaving group.Type: ApplicationFiled: September 14, 2011Publication date: February 23, 2012Applicant: SALTIGO GMBHInventors: Mark Sundermeier, Matthias Gotta, Axel Jacobi von Wangelin, Waldermar Maximilian Czaplik
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Patent number: 8101666Abstract: The invention provides methods for detection of medical disorders, associated with cellular oxidative stress, cell degeneration and/or cell death. The invention further relates to compounds comprising a thiol (—SH) group, for detecting cells undergoing oxidative stress, degeneration and/or a death process. The invention further provides methods for utilizing the compounds in medical practice, for diagnostic and therapeutic purposes.Type: GrantFiled: July 7, 2005Date of Patent: January 24, 2012Assignee: Aposense Ltd.Inventors: Ilan Ziv, Anat Shirvan
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Patent number: 8097760Abstract: This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.Type: GrantFiled: March 30, 2007Date of Patent: January 17, 2012Assignee: Sunovion Pharmacuticals Inc.Inventors: Hang Zhao, Stefan G. Koenig, Charles P. Vandenbossche, Surendra Singh, Harold Scott Wilkinson, Roger P. Bakale
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Publication number: 20120004262Abstract: The present invention relates to phenylcyclopropylamine derivatives. In particular, pharmaceutical compositions comprising phenylcyclopropylamine derivatives are provided. The compounds of this invention can, inter alia, be used for the treatment and the prevention of cancer as well as neurodegenerative diseases or disorders.Type: ApplicationFiled: January 21, 2010Publication date: January 5, 2012Inventors: Nathalie Guibourt, Alberto Ortega Munoz, Julio Castro-Palomino Laria
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Publication number: 20110319665Abstract: The present invention relates to a process for preparing substituted 2-nitrobiphenyls and to specific 2-nitrobiphenyls. The invention further relates to a process for preparing 2-aminobiphenyls from such 2-nitrobiphenyls and to a process for preparing (het)arylamides of such 2-aminobiphenyls.Type: ApplicationFiled: March 8, 2010Publication date: December 29, 2011Applicant: BASF SEInventors: Alexander Korte, Jan Klaas Lohmann, Thomas Grote, Klaus Ebel, Thomas Zierke, Horst Mayer, Ralf Wazulek
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Patent number: 8080689Abstract: Disclosed are compounds represented by structural formula (I): methods of producing compounds represented by structural formula (I), and their use in inhibiting oxidation in an oxidizable material.Type: GrantFiled: August 11, 2010Date of Patent: December 20, 2011Assignee: Polnox CorporationInventors: Rajesh Kumar, Suizhou Yang, Vijayendra Kumar, Ashok L. Cholli
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Publication number: 20110306646Abstract: The present invention relates to a N-(Phenylcycloalkyl)carboxamide or N-(Benzylcycloalkyl)carboxamide or its thiocarboxamide derivative of formula (I) wherein A represents a carbo-linked, unsaturated or partially saturated, substituted or non-substituted 5-membered heterocyclyl group, T represents an oxygen or a sulphur atom, B represents a non aromatic carbocycle that can be substituted by one to four C1-C8-alkyl groups, and X, Z1, Z2 and Z3 represent various substituents; their process of preparation; the preparation of intermediate compounds; their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.Type: ApplicationFiled: February 16, 2010Publication date: December 15, 2011Inventors: Jurgen Benting, Peter Dahmen, Philippe Desbordes, Stephanie Gary, Marie-Claire Cournoyer, Philippe Rinolfi, Ulrike Wachendorff-Neumann
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Publication number: 20110301356Abstract: The present invention relates to a process for preparing 2-aminobiphenyls of the formula I in which n is 0, 1, 2 or 3, R1 is hydrogen, cyano or fluorine, and each R2 is independently selected from cyano, fluorine, C1-C4-alkyl, C1-C4-fluoroalkyl, C1-C4-alkoxy, C1-C4-fluoroalkoxy, C1-C4-alkylthio and C1-C4-fluoroalkylthio. The invention also relates to a process for preparing pyrazolecarboxamides of such 2-aminobiphenyls.Type: ApplicationFiled: February 18, 2010Publication date: December 8, 2011Applicant: BASF SEInventors: Thomas Zierke, Volker Maywald, Sebastian Peer Smidt
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Publication number: 20110265878Abstract: The present invention relates to a dye comprising a chromophore to which an acyloin group as anchoring group is attached, to a method of synthesis of such dye, to an electronic device comprising such dye and to the use of such dye.Type: ApplicationFiled: September 23, 2009Publication date: November 3, 2011Applicant: Sony CorporationInventors: Gerda Fuhrmann, Gabriele Nelles, Ameneh Bamedi Zilai, Markus Obermaier
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Publication number: 20110257404Abstract: [Problem] To provide a method of producing an aromatic amino compound by using a primary or secondary amine compound and a halogenated aromatic compound as starting materials, and relying upon the Ullmann reaction, the method being capable of obtaining the highly pure aromatic amino compound in high yields and inexpensively.Type: ApplicationFiled: January 25, 2010Publication date: October 20, 2011Applicant: HODOGAYA CHEMICAL CO., LTD.Inventors: Norimasa Yokoyama, Makoto Nagaoka, Kazunori Togashi
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Publication number: 20110253985Abstract: This invention relates to triarylamine compounds that are useful in electronic applications. It also relates to electronic devices in which the active layer includes such a compound.Type: ApplicationFiled: October 19, 2010Publication date: October 20, 2011Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Ying Wang, Weishi Wu, Kerwin D. Dobbs
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Publication number: 20110253986Abstract: This invention relates to triarylamine compounds that are useful in electronic applications. It also relates to electronic devices in which the active layer includes such a compound.Type: ApplicationFiled: October 19, 2010Publication date: October 20, 2011Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Ying Wang, Weishi Wu, Kerwin D. Dobbs
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Patent number: 8039671Abstract: Provided are a novel transition metal complex where a monocyclopentadienyl ligand to which an amido group is introduced is coordinated, a catalyst composition including the same, and an olefin polymer using the catalyst composition. The transition metal complex has a pentagon ring structure having an amido group connected by a phenylene bridge in which a stable bond is formed in the vicinity of a metal site, and thus, a sterically hindered monomer can easily approach the transition metal complex. By using a catalyst composition including the transition metal complex, a linear low density polyolefin copolymer having a high molecular weight and a very low density polyolefin copolymer having a density of 0.910 g/cc or less can be produced in a polymerization of monomers having large steric hindrance. Further, the reactivity for the olefin monomer having large steric hindrance is excellent.Type: GrantFiled: March 7, 2011Date of Patent: October 18, 2011Assignee: LG Chem, Ltd.Inventors: Choong Hoon Lee, Eun Jung Lee, Seungwhan Jung, Boram Lee, Jung A Lee, Bun Yeoul Lee
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Publication number: 20110251287Abstract: A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.Type: ApplicationFiled: June 21, 2011Publication date: October 13, 2011Applicant: Gruenenthal GmbHInventors: Michael GRUSS, Andreas Fischer, Markus Kegel, Wolfgang Hell, Markus Von Raumer, Joerg Berghausen, Susan Margaret Paul
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Patent number: 8029920Abstract: The invention provides a 1,3,5-tris(diarylamino)benzene represented by the general formula (I) wherein A and B are each independently a group represented by the general formula (II) in which R is a hydrogen atom, an alkyl group of 1-6 carbons or a cycloalkyl group of 5 or 6 carbons and n is 0, 1, 2 or 3, provided that the values of n of A and B are not the same to each other. Such a 1,3,5-tris(diarylamino)benzene is able to form an amorphous film by vacuum evaporation at a relatively low temperature with almost or substantially no thermal decomposition, and is preferably used as organo-electronic functional material, in particular, as a hole injecting agent or a hole transporting agent.Type: GrantFiled: March 8, 2007Date of Patent: October 4, 2011Assignee: Bando Chemical Industries, LtdInventors: Nobutaka Akashi, Hideyuki Katou
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Publication number: 20110217642Abstract: A charge transport particle comprising a plurality of segments and a plurality of linkers arranged as a covalent organic framework, wherein at a macroscopic level the covalent organic framework is a particle that has electroactive added functionality.Type: ApplicationFiled: March 3, 2010Publication date: September 8, 2011Applicant: XEROX CORPORATIONInventors: Matthew A. Heuft, Adrien Pierre Cote
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Publication number: 20110218330Abstract: The present invention relates to a pyrimidine compound (I) useful as a pharmaceutical intermediate, to a process for preparing said pyrimidine compound, to intermediates used in said process, and to the use of said pyrimidine compound in the preparation of pharmaceuticals.Type: ApplicationFiled: March 24, 2011Publication date: September 8, 2011Applicant: AstraZeneca ABInventors: Ulf Larsson, Mattias Magnusson, Tibor Musil, Andreas Palmgren
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Patent number: 8008286Abstract: Compounds and methods useful for preventing and treating pain, e.g., neuropathic pain, in a subject in need thereof are provided. The compounds can be “S1P modulating” agents that are capable of inducing a detectable change in S1P receptor activity.Type: GrantFiled: July 25, 2008Date of Patent: August 30, 2011Assignee: University of Virginia Patent FoundationInventors: Kevin R. Lynch, Timothy L. Macdonald
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Publication number: 20110190520Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.Type: ApplicationFiled: February 8, 2011Publication date: August 4, 2011Applicant: AstraZeneca ABInventors: Adrian Clark, Elfyn Jones, Ulf Larsson, Anna Minidis
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Patent number: 7960587Abstract: The present invention relates to novel compounds and compositions comprising novel oligomers and polymers, and electronic device comprising at least one layer containing the compositions. The novel oligomers and polymers can be solubilized, and can be used in solution to form electronic devices. The compounds can function as monomers, and copolymers can be formed from such monomers, such copolymers comprising, as polymerized units, a plurality of units of the compounds.Type: GrantFiled: February 19, 2004Date of Patent: June 14, 2011Assignee: E.I. du Pont de Nemours and CompanyInventors: Norman Herron, Gary A. Johansson, Nora Sabina Radu, Eric Maurice Smith, Arthur Dabrowski, Frederick P. Gentry, Gene M. Rossi
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Publication number: 20110131029Abstract: Provided are the expression method of influenza virus polymerase PAc-PB1N complex, the co-crystallization method of the complex and the three-dimendional structure of the crystal of PAc-PB1N complex. Also provided are the compounds binding to the influenza virus polymerase PAc and the expression method of influenza virus polymerase PAN. The three-dimensional structure of the crystal of PAc-PB1N complex can be used for screening and designing the drug for the treatment of influenza.Type: ApplicationFiled: February 22, 2009Publication date: June 2, 2011Inventors: Yingfang Liu, Xiaojing He, Zonghao Zeng, Jie Zhou
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Publication number: 20110108823Abstract: The present invention relates to aromatic amines and to electronic devices in which these amines are used, in particular, as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.Type: ApplicationFiled: September 10, 2009Publication date: May 12, 2011Applicant: MERCK PATENT GMBHInventors: Philipp Stoessel, Holger Heil, Dominik Joosten, Christof Pflumm, Anja Gerhard
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Publication number: 20110105543Abstract: This invention relates to novel triaryl derivatives, formula (I), a stereoisomer thereof or a mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein all of X, Y and Z represent CH; or one or two of X, Y and Z represent N; and the others of X, Y and Z represent CH; and R1, R2, R3, R4 and R5. independently of each other, represent hydrogen, halo, tri-fluoromethyl, trifluoromethoxy, cyano, hydroxyl, alkoxy, alkyl, amino or sulfamoyl; or R1 and R2, together with the phenyl ring to which they are attached form an indolyl ring or a benzo-dioxolyl ring; and R3, R4 and R5 are as defined above; and R6 represents amino or nitro, which are found to be modulators of the nicotinic acetylcholine receptors.Type: ApplicationFiled: March 9, 2009Publication date: May 5, 2011Applicant: NeuroSearch A/SInventors: Antonio Nardi, Jeppe Kejser Christensen, Dan Peters
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Publication number: 20110105760Abstract: The present invention relates to a process for preparing substituted 2-aminobiphenyls and to a process for preparing (Het)arylamides of such 2-aminobiphenyls.Type: ApplicationFiled: July 3, 2009Publication date: May 5, 2011Applicant: BASF SEInventors: Michael Keil, Michael Rack, Thomas Zierke, Markus Heinrich, Alexander Wetzel
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Publication number: 20110095269Abstract: A compound having Formula I, Formula II, or Formula III: Ar1 may independently be phenylene, substituted phenylene, naphthylene, or substituted naphthylene. Ar2 is the same or different at each occurrence and is an aryl group. M is the same or different at each occurrence and is a conjugated moiety. T1 and T2 are independently the same or different at each occurrence and are conjugated moieties which are connected in a non-planar configuration; a and e are the same or different at each occurrence and are an integer from 1 to 6; b, c, and d are mole fractions such that b+c+d=1.0, with the proviso that c is not zero, and at least one of b and d is not zero, and when b is zero, M has at least two triarylamine units; and n is an integer greater than 1.Type: ApplicationFiled: November 17, 2008Publication date: April 28, 2011Inventors: CHI ZHANG, CHE-HSIUNG HSU
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Publication number: 20110059999Abstract: The invention relates to compounds which have an affinity for the ? opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.Type: ApplicationFiled: September 22, 2010Publication date: March 10, 2011Applicant: GRÜNENTHAL GMBHInventors: Sven Frormann, Saskia Zemolka, Klaus Linz, Werner Englberger, Fritz Theil
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Patent number: 7902402Abstract: The present invention provides a method for producing a tetramine compound represented by formula (1): wherein R1, R2 and R3, which may be the same or different, each represents a hydrogen atom, a tertiary alkyl group having 4 to 8 carbon atoms, an unsubstituted aryl group or an aryl group substituted with a tertiary alkyl group having 4 to 8 carbon atoms, and n represents 3 or 4.Type: GrantFiled: January 15, 2010Date of Patent: March 8, 2011Assignee: Hodogaya Chemical Co., Ltd.Inventors: Shigeru Kusano, Makoto Koike, Atsushi Takesue, Mitsutoshi Anzai