Hydrazines Patents (Class 564/310)
  • Patent number: 5789139
    Abstract: A hydrazide compound represented by the following formula (I), and a silver halide photographic photonsensitive material comprising the hydrazide compound:A--(B).sub.b (I)wherein A represents a heterocyclic group, a condensed polycyclic aromatic group or a group formed by connecting at least two aromatic groups to each other, B represents a group represented by the following formula (I-B) or (II-B), and b represents an integer from 2 to 6;--L.sub.1 --Ar.sub.1 --NHNH--G.sub.1 --R.sub.1 (I-B)--L.sub.3 --Ar.sub.3 --L.sub.2 --Ar.sub.2 --NHNH --G.sub.2 --R.sub.2(II-B)wherein each of G.sub.1 and G.sub.2 represents a carbonyl group, an oxalyl group, a sulfonyl group or a phosphoryl group; each of R.sub.1 and R.sub.2 represents a hydrogen atom or a blocking group; each of Ar.sub.1, Ar.sub.2 and Ar.sub.3 represents an aromatic group or an aromatic heterocyclic group; and each of L.sub.1, L.sub.2 and L.sub.3 represents a linkage group.
    Type: Grant
    Filed: December 27, 1996
    Date of Patent: August 4, 1998
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Kohzaburoh Yamada, Hiroyuki Suzuki, Toshihide Ezoe, Koji Kawato
  • Patent number: 5756752
    Abstract: Substituted oxadiazolones of the formula (I) ##STR1## in which R represents optionally substituted alkyl, are obtained in good yields and high purity on reacting in a first step carboxylic acids of the general formula (II)R--COOH (II)with hydrazine hydrate in the presence of a catalyst and an inert diluent at temperatures between 0.degree. C. and 150.degree. C. with elimination of water and removal of said catalyst and reacting the resulting carboxylic hydrazides of the general formula (III)R--CO--NH--NH.sub.2 (III)in a second step with phosgene (COCl.sub.2) at temperatures between 20.degree. C. and 120.degree. C.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: May 26, 1998
    Assignees: Bayer Corporation, Bayer Aktiengesellschaft
    Inventors: Hans Joachim Diehr, Reinhard Lantzsch, Jacqueline M. Applegate, Klaus Jelich
  • Patent number: 5659041
    Abstract: Radionuclide chelating compounds are provided for conjugation to targeting molecules such as proteins, peptides or antibodies. The resulting labeled targeting molecules may be used in diagnosis and therapy.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: August 19, 1997
    Assignee: Resolution Pharmaceuticals, Inc.
    Inventors: Alfred Pollak, Robert A. Kirby, Robert Dunn-Dufault
  • Patent number: 5612479
    Abstract: Novel polycyanate compositions containing one or more mesogenic moieties as lateral substituents are disclosed which provide improved processability relative to polycyanates containing one or more mesogenic moieties in the main chain of the molecule. Molecular level ordering of the resulting thermosets is maintained much similar to that found thermosets of polycyanates which have one or more mesogenic moieties in the main chain.
    Type: Grant
    Filed: August 17, 1994
    Date of Patent: March 18, 1997
    Assignee: The Dow Chemical Company
    Inventors: Robert E. Hefner, Jr., Jimmy D. Earls
  • Patent number: 5610183
    Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein Q is optionally substituted phenyl or naphthyl;X and Y are each H, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or X and Y are together .dbd.O;Z is O or S;R.sup.1 is H, optionally substituted C.sub.1-6 alkyl, optionally substituted phenyl (C.sub.1-4 alkyl), C.sub.2-6 alkenyl, COC.sub.1-6 alkylhalo, COR.sup.a, COOR.sup.a, CONHR.sup.a, COC.sub.1-6 alkylNR.sup.a R.sup.b or CONR.sup.a C.sub.1-6 alkylCONR.sup.a R.sup.b ;R.sup.2 is substituted C.sub.1-6 alkyl, optionally substituted phenyl(C.sub.1-4 alkyl), C.sub.2-6 alkenyl, C.sub.1-6 alkylhalo, COR.sup.a, COOR.sup.a, CONHR.sup.a, COC.sub.1-6 alkylNR.sup.a R.sup.b or CONR.sup.a C.sub.1-6 alkylCONR.sup.a R.sup.b ;or R.sup.1 and R.sup.2 together form a chain (CH.sub.2).sub.p optionally substituted by oxo;R.sup.3 is H [or C.sub.1-6 alkyl];R.sup.4 is H, C.sub.1-6 alkyl or phenyl; andR.sup.5 is optionally substituted (CH.sub.2).sub.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: March 11, 1997
    Assignee: Merck, Sharp & Dohme Ltd.
    Inventors: Andrew P. Owens, Brian J. Williams
  • Patent number: 5585521
    Abstract: Alkylhydrazine salts are prepared on an industrial scale and with good results by reacting together hydrazine, an alkene and a strong protonic acid in the presence of water, hydrazine and the protonic acid being introduced, the alkene being added, the liquid and gaseous phases present in the reaction vessel being intensively mixed together at 75.degree. to 150.degree. C., then the reaction mixture being cooled to temperatures below 60.degree. C., the precipitated alkylhydrazine salt being separated off, hydrazine and strong protonic acid being again added to the mother liquor, then alkene being added again and the next reaction cycle being thus carried out.
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: December 17, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfram Eichinger, Helmut Fiege
  • Patent number: 5530028
    Abstract: Insecticidal compounds having the formula N-(2-R.sup.a -3-R.sup.b -4-R.sup.h -benzoyl)-N'-(2-R.sup.c -3-R.sup.d -4-R.sup.e -5-R.sup.f -benzoyl)-N'-R.sup.g -hydrazine wherein R.sup.a is a halo or lower alkyl; R.sup. b is lower alkoxy, optionally substituted with halo (preferably fluoro); R.sup.c is selected from hydrogen, halo, lower alkyl, lower alkoxy, lower alkoxy lower alkyl, and nitro; R.sup.d, R.sup.e and R.sup.f are each independently selected from hydrogen, bromo, chloro, fluoro, lower alkyl, lower alkoxy, and lower alkoxy lower alkyl; R.sub.g is a (C.sub.4 -C.sub.6)alkyl; R.sup.h is hydrogen, lower alkoxy, lower alkyl, or when taken together with R.sup.b is methylenedioxy (--OCH.sub.2 O--), 1,2-ethylenedioxy (--OCH.sub.2 CH.sub.2 O--), 1,2-ethyleneoxy (--CH.sub.2 CH.sub.2 O--) or 1,3-propyleneoxy (--CH.sub.2 CH.sub.2 CH.sub.2 O--) wherein an oxo atom is located at the R.sup.b position; and the substituents R.sup.c and R.sup.d, or R.sup.d and R.sup.e, or R.sup.e and R.sup.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: June 25, 1996
    Assignee: Rohm and Haas Company
    Inventors: Zev Lidert, Dat P. Le, Robert E. Hormann, Thomas R. Opie
  • Patent number: 5523455
    Abstract: A compound of formula: ##STR1## in which R.sub.y represents a cyano or carboxymethyl group and its salts.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: June 4, 1996
    Assignee: Sanofi
    Inventors: Bernard Labeeuw, Danielle Gully, Francis Jeanjean, Jean-Charles Molimard, Robert Boigegrain
  • Patent number: 5516940
    Abstract: A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from the phosphorous or germanium core.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: May 14, 1996
    Assignee: Curators of the University of Missouri
    Inventors: Kattesh V. Katti, Wynn A. Volkert, Alan R. Ketring, Prahlad R. Singh
  • Patent number: 5489711
    Abstract: An oligomer from diarylamines is disclosed which has desirable antioxidant properties in lubricating oils which contain synthetic ester lubricants. The oligomer is desirable for use at higher temperatures where it has less volatility than simple diarylamines. The oligomer has substantial portions of monosubstituted diphenylamine repeat units which result in linear oligomers. Di and polysubstituted diphenylamines may optionally be present as repeat units. These di and polysubstituted diphenylamines generally react as monofunctional reactants in oligomerization and tend to reduce the number of repeat units in the average oligomer.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: February 6, 1996
    Assignee: The B. F. Goodrich Company
    Inventor: John T. Lai
  • Patent number: 5302370
    Abstract: The invention relates to compounds having the general formula I ##STR1## where A if required can contain a functional and/or activated group C for coupling to selectively concentrating compounds or can contain a selectively concentrating compound coupled via the group C. B and B' are functional groups for coordinate bonding of groups carrying metal ions. The novel compounds are for forming complexes with radioactive metal ions, more particularly rhenium and technetium isotopes, and are used in medical diagnosis and therapy.
    Type: Grant
    Filed: August 22, 1990
    Date of Patent: April 12, 1994
    Assignee: Institut fur Diagnostikforschung GmbH
    Inventors: Reinhard Neumeier, Wolfgang Kramp, Helmut R. Macke
  • Patent number: 5232836
    Abstract: Vitamin D derivatives corresponding to the following formula I ##STR1## in which R.sub.1 denotes a substituted alkyl group having 1 to 15 carbon atoms, in particular the side chains of vitamin D.sub.2 (C.sup.20 to C.sup.28) or D.sub.3 (C.sup.20 to C.sup.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: August 3, 1993
    Assignee: Ire-Medgenix S.A.
    Inventors: Roger Bouillon, Pierre J. De Clerco, Pierre Eliard, Maurits Vanderwalle
  • Patent number: 5229417
    Abstract: Novel 2-(3-phenylpropyl)hydrazines, intermediates in and processes for the preparation thereof, and a method of treating personality disorders utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: December 5, 1991
    Date of Patent: July 20, 1993
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Richard C. Effland, Joseph T. Klein
  • Patent number: 5206437
    Abstract: The present invention relates to novel calixarene derivatives having an inclusion activity which are useful for selective transportation of various metal ions, possess a biological activity and a redox activity, and are not only capable of forming conductive or photoconductive electron transfer complexes but also have strong ability of forming complexes and absorbing UV rays. The present invention also relates to intermediates of calixarene derivatives as well as processes for production thereof.
    Type: Grant
    Filed: October 2, 1990
    Date of Patent: April 27, 1993
    Inventor: Yutaka Morita
  • Patent number: 5104910
    Abstract: Described herein is an isocyanate-reactive compound containing at least one linkage of the formula:--X--X--wherein X is independently in each occurrence --NR--, --S--, or --O--; R is independently in each occurrence hydrogen, C.sub.1-10 alkyl, aryl, or arylene; and at least one N, S, or O atom of the above formula is bonded to an aryl or arylene group. Also disclosed are isocyanate-reactive compositions containing the above compound and flexible polyurethane foams prepared therefrom.
    Type: Grant
    Filed: January 3, 1991
    Date of Patent: April 14, 1992
    Assignee: The Dow Chemical Company
    Inventors: Robert B. Turner, Ralph D. Priester, Jr., Stephen R. Burkes
  • Patent number: 5082938
    Abstract: Enhanced branched chain hydroxyl compounds are provided of formulaY--(Z).sub.1-6wherein Y is the residue of a nucleophile devoid of conjugated divalent linking moieties, and each Z is a poly(oxyalkylene) moiety having a molecular weight of from about 200-10,000 and containing at least one glycidol residue, wherein at least one of the primary oxy sites of said glycidol residue is linked preferably directly to a first epoxide residue of three or more carbons, and wherein said first epoxide residue is linked through a secondary oxy site preferably directly to a second epoxide reside having a primary terminal hydroxyl.
    Type: Grant
    Filed: March 1, 1990
    Date of Patent: January 21, 1992
    Assignee: Milliken Research Corporation
    Inventors: Edward W. Kluger, David J. Moody
  • Patent number: 5051531
    Abstract: The present invention relates to a novel antioxidant-peroxide compound of Structure A,(Y--[R--OO--X).sub.x --An].sub.y Ain which the definitions of X, Y, R, An, x, and y are given in the Summary of the Invention section, for example, t-butyl peroxy-3-(3,5-di-t-butyl-4-hydroxypheneyl) propionate, processes for producing polymeric composition of enhanced oxidative stability via initiation of polymerization of ethylenically unsaturated monomers, curing of elastomers and unsaturated polyester resins, modification of polypropylene and other polymers and copolymers, and crosslinking of olefin polymers and copolymers, and the resulting polymers having enhanced oxidative stability.
    Type: Grant
    Filed: May 31, 1988
    Date of Patent: September 24, 1991
    Assignee: Atochem North America, Inc.
    Inventor: Jose Sanchez
  • Patent number: 4933480
    Abstract: A compound of the formula: ##STR1## wherein R is a C.sub.2 -C.sub.3 alkyl group, a C.sub.3 -C.sub.4 alkenyl group, or a C.sub.3 -C.sub.4 alkynyl group, and X is a chlorine or bromine atom, is disclosed. These compounds are useful as intermediates in the production of herbicidal 3-chlorotetrahydroindazoles.
    Type: Grant
    Filed: August 3, 1989
    Date of Patent: June 12, 1990
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toru Haga, Eiki Nagano, Ryo Sato, Ryo Yoshida
  • Patent number: 4892964
    Abstract: In one embodiment this invention provides a nonlinear optical medium which is a transparent film of a thermoplastic polymer composed of recurring monomeric units corresponding to the formula: ##STR1##
    Type: Grant
    Filed: June 22, 1988
    Date of Patent: January 9, 1990
    Assignee: Hoechst Celanese Corporation
    Inventor: Eui W. Choe
  • Patent number: 4864032
    Abstract: A process for the preparation of aryl hydrazines and indazoles by reacting organometallic regents with azodicarboxylates.
    Type: Grant
    Filed: July 2, 1987
    Date of Patent: September 5, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: James P. Demers
  • Patent number: 4844729
    Abstract: Substituted N-phenylpyridazone derivatives of the general formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are each hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkylthio, C.sub.1 -C.sub.4 -alkylsulfinyl, C.sub.1 -C.sub.4 -alkylsulfonyl, halogen, cyano, phenyl, phenoxy, or phenylthio and Z is a straight-chain, saturated alkylene group of 1 to 5 carbon atoms, herbicides containing these compounds, and a process for combating the growth of unwanted plants.
    Type: Grant
    Filed: May 28, 1987
    Date of Patent: July 4, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Rainer Becker, Ulrich Wriede, Ulrich Schirmer, Adolf Parg, Bruno Wuerzer, Norbert Meyer
  • Patent number: 4841009
    Abstract: Described herein are novel substantially linear monomeric compositions which can be polymerized with one or more difunctional monomers to give novel polymeric compositions having liquid crystal properties. This invention is also directed to a process for preparation of the novel substantially linear monomeric compositions.
    Type: Grant
    Filed: July 5, 1985
    Date of Patent: June 20, 1989
    Assignee: Amoco Corporation
    Inventor: Donald R. Kelsey
  • Patent number: 4835286
    Abstract: Various intermediates useful in the production of herbicidal 2-substituted phenyl-4,5,6,7-tetrahydro-2H-indazole compounds are disclosed. These intermediates have the following formulas: ##STR1## wherein X is chlorine or bromine, Z is chlorine or methyl, and A is amino, hydroxyl, or nitro; ##STR2## wherein B is nitro or hydroxy, and X is chlorine or bromine.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: May 30, 1989
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Eiki Nagano, Ichiki Takemoto, Masayuki Fukushima, Ryo Yoshida, Hiroshi Matsumoto
  • Patent number: 4772747
    Abstract: Disclosed is a process for the preparation of 2,4,6-trichlorophenylhydrazine by chlorinating the reaction product of phenylhydrazine and a dicarboxylic anhydride to obtain an N-(2,4,6-trichloroanilino)dicarboximide which is reacted with a base capable of liberating 2,4,6-trichlorophenylhydrazine therefrom.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: September 20, 1988
    Assignee: Eastman Kodak Company
    Inventors: Kevin J. Edgar, John A. Hyatt
  • Patent number: 4771063
    Abstract: New fungicides which are N-aryl-N-acyl-3-amino-oxazolidin-2-ones and use thereof in fighting infections of useful plants by fungi are disclosed. The compounds of the invention have a high fungicidal activity combined with a good compatibility with the plants to be defended against attack by fungi.
    Type: Grant
    Filed: August 5, 1987
    Date of Patent: September 13, 1988
    Assignee: Montedison S.p.A
    Inventors: Luigi Garlaschelli, Franco Gozzo, Luigi Mirenna
  • Patent number: 4725302
    Abstract: Phenylhydrazines of the formula I ##STR1## wherein R.sub.1 is --A--R--Z,A is oxygen, sulfur, ##STR2## R is C.sub.1 -C.sub.6 -alkylene, C.sub.1 -C.sub.6 -haloalkyl-C.sub.1 -C.sub.6 -alkylene, C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.6 -alkylene or C.sub.1 -C.sub.6 -alkylthio-C.sub.1 -C.sub.6 -alkylene,Z is halogen, C.sub.1 -C.sub.6 -haloalkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulfinyl or C.sub.1 -C.sub.6 -alkylsulfonyl, orR and Z together are ##STR3## R.sub.2 is hydrogen, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio or (C.sub.1 -C.sub.6 -alkyl).sub.2 amino,n is a number from 1-4, and R.sub.2 can be different when n is one of the numbers 2-4,R.sub.3 is halogen,R.sub.4 is hydrogen,R.sub.5 is --COOR.sub.6, orR.sub.3, R.sub.4 and R.sub.5 together form a bridge member of the formula ##STR4## and R.sub.6 is C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl or C.sub.2 -C.sub.6 -alkynyl.
    Type: Grant
    Filed: November 20, 1985
    Date of Patent: February 16, 1988
    Assignee: Ciba-Geigy Corporation
    Inventor: Josef Ehrenfreund
  • Patent number: 4717492
    Abstract: A product of reaction suitable for use as a lubricant additive made by reacting a preformed Mannich base with a reactive hydrocarbyl amine, thiol or dithiophosphoric acid having at least one reactive hydrogen.
    Type: Grant
    Filed: December 27, 1985
    Date of Patent: January 5, 1988
    Assignee: Mobil Oil Corporation
    Inventor: Sheldon Chibnik
  • Patent number: 4698444
    Abstract: 1,1-Di(p-fluorophenyl)urea, 2-carbobenzoxy-8-fluoro-5-(p-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4, 3-b]indole, an efficient process for converting the former to the latter, further comprising conversion of the latter to 8-fluoro-5-(p-fluorophenyl)-2-[4-(p-fluorophenyl)-4-hydroxybutyl)]-2,3,4,5 -tetrahydro-1H-pyrido[4,3-b]indole (flutroline) or to 8-fluoro-5-(p-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (an alternative flutroline intermediate).
    Type: Grant
    Filed: December 17, 1985
    Date of Patent: October 6, 1987
    Assignee: Pfizer Inc.
    Inventor: Stephen S. Massett
  • Patent number: 4568748
    Abstract: 1,1-Di(p-fluorophenyl)urea, 2-carbobenzoxy-8-fluoro-5-(p-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4, 3-b]indole, an efficient process for converting the former to the latter, further comprising conversion of the latter to 8-fluoro-5-(p-fluorophenyl)-2-[4-(p-fluorophenyl)-4-hydroxybutyl)-]2,3,4,5 -tetrahydro-1H-pyrido[4,3-b]indole (flutroline) or to 8-fluoro-5-(p-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (an alternative flutroline intermediate).
    Type: Grant
    Filed: August 16, 1984
    Date of Patent: February 4, 1986
    Assignee: Pfizer Inc.
    Inventor: Stephen S. Massett
  • Patent number: 4526608
    Abstract: Substituted phenoxyphenylhydroxyamines and pyridyloxyphenylhydroxyamines, and the use thereof for the control of weeds.
    Type: Grant
    Filed: March 31, 1983
    Date of Patent: July 2, 1985
    Assignee: Zoecon Corporation
    Inventor: Shy-Fuh Lee
  • Patent number: 4507475
    Abstract: A process for purifying crude polyether polyols which are prepared by anionic polymerization of alkylene oxides in the presence of basic catalysts. The polyols are mixed with water and ortho-phosphoric acid in certain quantity ratios, an adsorption agent is incorporated in the reaction mixture, the mixture is filtered and the water is removed from the polyether polyol by distillation.
    Type: Grant
    Filed: July 22, 1983
    Date of Patent: March 26, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Straehle, Raymond Denni, Matthias Marx
  • Patent number: 4482547
    Abstract: This invention relates to substituted-1,3,4-benzotriazepines of the formula ##STR1## wherein X and Y are each independently hydrogen, lower alkyl, halogen, lower alkoxy, nitro and hydroxyl; R.sub.1 and R.sub.3 are each independently hydrogen or alkyl; R.sub.2 is hydrogen, lower alkyl, cycloalkyl lower alkyl, phenyl, Ar lower alkyl, hydroxyl and sulfhydryl; m and n are each independently integers of 0 or 1 and when m is 0, n is 1 and vice-versa; and p and q are independently integers of 1 or 2. Also included in the invention are the substituted-1,3,4-benzotriazepine derivatives of tautomeric form when the substituent for R.sub.1 and/or R.sub.3 in the above formula is hydrogen. The compound of this invention may be used as antihypertensive agents.
    Type: Grant
    Filed: August 26, 1982
    Date of Patent: November 13, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Lawrence L. Martin, Linda L. Setescak
  • Patent number: 4477668
    Abstract: (+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine, and its pharmaceutically acceptable salts is useful as an anxiolytic, antidepressant, anticonvulsant, muscle relaxant and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease. The racemate of the compound is produced by a four-step synthetic process in about 65% yield from 5H-dibenzo[a,d]cyclohepten-5-one.
    Type: Grant
    Filed: September 3, 1982
    Date of Patent: October 16, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Dean R. Bender, Sandor Karady, Theresa Rothauser
  • Patent number: 4459227
    Abstract: Iminoquinone precursors having the formula ##STR1## wherein R.sub.1 represents hydrogen or an enzymatically hydrolyzable group; R.sub.2 and R.sub.3 independently represent hydrogen, a non-electron-withdrawing organic substituent or an enzymatically hydrolyzable group except that when R.sub.1 is hydrogen, R.sub.2 must be an enzymatically hydrolyzable group and R.sub.3 must not inhibit the hydrolysis of R.sub.2 ; R.sub.4 represents hydrogen or an electron-withdrawing or non-electron-withdrawing organic substituent, except that if R.sub.1 is hydrogen, R.sub.4 may not inhibit the hydrolysis of R.sub.2 ; W, X, Y and Z independently represent hydrogen or an electron-withdrawing or non-electron-withdrawing organic substituent, or any one of X and W, Y and Z, or X and R.sub.
    Type: Grant
    Filed: March 2, 1981
    Date of Patent: July 10, 1984
    Assignee: Duke University
    Inventors: Reinhardt O. Sahmel, Doyle G. Graham
  • Patent number: 4404019
    Abstract: A compound of the formula: ##STR1## wherein R is a C.sub.1 -C.sub.4 alkyl group, a C.sub.3 -C.sub.4 alkenyl group or a C.sub.3 -C.sub.4 cycloalkyl group, X is a chlorine atom or a bromine atom and Y is a hydrogen atom or a C.sub.1 -C.sub.4 alkoxy group, which is useful as a herbicide.
    Type: Grant
    Filed: December 8, 1981
    Date of Patent: September 13, 1983
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Tamon Uematsu, Shunichi Hashimoto, Hiroshi Matsumoto
  • Patent number: 4374271
    Abstract: N-Amino substituted aniline and 1,3-phenylenediamine compounds having 1 or 2 nitro groups on the aromatic ring. The compounds are useful as herbicides and as intermediates for preparing herbicides.
    Type: Grant
    Filed: April 4, 1979
    Date of Patent: February 15, 1983
    Assignee: United States Borax & Chemical Corporation
    Inventors: Don L. Hunter, William G. Woods, James D. Stone, Cecil W. LeFevre
  • Patent number: 4364875
    Abstract: The method of preparing a compound of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen, alkyl of 1 to 8 carbon atoms, trifluoromethyl or acetyl;n is 1 when R.sub.1 has all the defined meanings, or 2 or 3 when R.sub.1 is halogen or alkyl;R.sub.2 is hydrogen; alkyl of 1 to 16 carbon atoms; alkenyl of 2 to 16 carbon atoms; alkinyl of 2 to 16 carbon atoms; monosubstituted alkyl of 2 to 6 carbon atoms, where the substituent is hydroxyl, alkoxy of 1 to 4 carbon atoms, phenoxy, halo-phenoxy, (alkyl of 1 to 4 carbon atoms) phenoxy, (alkoxy of 1 to 4 carbon atoms)phenoxy, nitro-phenoxy, cyano-phenoxy, amino or (alkyl of 1 to 4 carbon atoms)thio; benzyl; halo-benzyl; --NR.sub.3 R.sub.4 ; --CHR.sub.3 --COOR.sub.4 ; or --CHR.sub.3 --CONR.sub.4 R.sub.5, whereR.sub.3, R.sub.4 and R.sub.5 are each hydrogen or alkyl of 1 to 8 carbon atoms; andX.sub.1 and X.sub.2 are each hydrogen or halogen,which comprises reacting a compound of the formula ##STR2## wherein n, R.sub.1, X.sub.1 and X.sub.
    Type: Grant
    Filed: July 7, 1981
    Date of Patent: December 21, 1982
    Assignee: Celamerck GmbH & Co. KG
    Inventors: Richard Sehring, Wolfgang Buck
  • Patent number: 4352760
    Abstract: The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A.sub.2 inhibitors. By virtue of this pharmacological property, they represent useful pharmacological agents for a wide variety of purposes.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: October 5, 1982
    Assignee: The Upjohn Company
    Inventor: Kirk M. Maxey
  • Patent number: 4318731
    Abstract: A novel .DELTA..sup.2 -1,2,4-triazolin-5-one derivative having a herbicidal activity, which is represented by the formula ##STR1## wherein, R.sup.1 is a C.sub.1 -C.sub.4 alkyl; R.sup.2 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, or a C.sub.2 -C.sub.4 alkenyl group; and X is a hydroxy group, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.6 alkyloxy group, an alkyloxyalkyloxy group of which two alkyls may be same as or different from each other and each alkyl is of C.sub.1 -C.sub.4, a C.sub.2 -C.sub.4 alkenyloxy, or an alkyloxycarbonylalkyloxy group of which two alkyls may be same as or different from each other and each alkyl is of C.sub.1 -C.sub.4.
    Type: Grant
    Filed: June 24, 1980
    Date of Patent: March 9, 1982
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Mitsuru Kajioka, Hitoshi Kurono, Katsumasa Okawa, Tatsuo Harada
  • Patent number: 4317741
    Abstract: Disclosed are selected poly(oxyalkylated) hydrazines of the formula: ##STR1## wherein R is selected from hydrogen, lower alkyl groups having from 1 to 4 carbon atoms, phenyl and mixtures thereof; and the sum of w, x, y, and z is from about 4 to about 20. These compounds are shown to be effective corrosion inhibitors for hydraulic fluids.
    Type: Grant
    Filed: January 29, 1981
    Date of Patent: March 2, 1982
    Assignee: Olin Corporation
    Inventors: Henry F. Lederle, Frank J. Milnes
  • Patent number: 4254128
    Abstract: The invention provides novel 2-adamantyl hydrazine derivatives of the general formula A ##STR1## In this formula R.sub.1 is hydrogen or a lower alkyl group of 1-4 carbon atoms; R.sub.2 and R.sub.3 are the same or different and are each hydrogen, an unsubstituted or substituted radical being a lower alkyl of 1-4 carbon atoms, a lower alkanoic acid radical of 2-4 carbon atoms or a lower alkyl ester thereof, adamantyl, aryl, aralkyl, in which the alkyl moiety has from 1-4 carbon atoms or an unsubstituted or substituted heterocyclic radical of aromatic character; or R.sub.2 and R.sub.3 together with the nitrogen atom to which they are attached form an unsubstituted or substituted non-aromatic cyclic radical.The invention further provides pharmaceutically acceptable acid addition salts of the above compounds.Several methods of preparation of the new compounds are described.
    Type: Grant
    Filed: November 22, 1978
    Date of Patent: March 3, 1981
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Ben-Zion Weiner, Raul Suchi, Jeffrey Sterling, Haim Yellin