Hydroxy, Bonded Directly To Carbon, Or Ether Containing (h Of -oh May Be Replaced By A Substituted Or Unsubstituted Ammonium Ion Or A Group Ia Or Iia Light Metal) Patents (Class 564/503)
Abstract: Cationic lipids are provided which are useful in the preparation of liposomes and other lipid vesicle carriers. The lipids of the invention are particularly useful as carriers of nucleic acids and other negatively charged substances, for delivery to cells.
Type:
Grant
Filed:
December 17, 1999
Date of Patent:
November 18, 2003
Assignees:
Valentis, Inc., Max-Planck-Gesellschaft zur Foerderung der Wissaschaften
B.V.
Inventors:
Hansjörg Eibl, Jinkang Wang, Yi Lin Zhang
Abstract: The present invention provides a process for industrially producing (aminomethyl)trifluoromethylcarbinol derivatives, in particularly, optically active compounds thereof, which are useful as starting compounds for drugs such as protease inhibitors, etc.
Abstract: The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I
The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.
Type:
Grant
Filed:
December 20, 2002
Date of Patent:
November 4, 2003
Assignee:
Warner-Lambert Company
Inventors:
Thomas Richard Belliotti, Justin Stephen Bryans, Ihoezo Victor Ekhato, Augustine Tobi Osuma, Robert Michael Schelkun, Jacob Bradley Schwarz, Andrew John Thorpe, Lawrence David Wise, David Juergen Wustrow, Po-Wai Yuen
Abstract: Iodohydroxylated olefins can be prepared by treating an olefin with an aqueous solution of an iodine monohalide selected from iodine monochloride and iodine monobromide.
Abstract: Disclosed is a method for enantioselectively-reducing a prochiral carbon-centered radical having one or more electron donator groups attached directly to the central prochiral carbon atom of the radical, and/or attached to a carbon atom within 1 to 4 atoms of the central prochiral carbon atom, comprising treating said radical with a chiral non-racemic organotin hydride in the presence of a Lewis acid.
Type:
Application
Filed:
October 1, 2002
Publication date:
September 4, 2003
Inventors:
Dainis Dakternieks, Carl H. Schiesser, Tamara Perchyonok
Abstract: Lipids and compositions of lipids that can be used as lipid aggregates (i.e., liposomes) for the delivery of macromolecules and other compounds into cells are provided.
Type:
Application
Filed:
January 4, 2002
Publication date:
July 17, 2003
Inventors:
Yong Liang Chu, Frank Q. Li, Jian-Tai Qiu, Jerry Lin
Abstract: Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.
Type:
Application
Filed:
October 16, 2002
Publication date:
July 10, 2003
Applicant:
SLIL Biomedical Corporation
Inventors:
Benjamin Frydman, Aldonia L. Valasinas, Andrei V. Blokhin, Hirak S. Basu, Laurence J. Marton
Abstract: This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or physiological salts of the free or conjugated compound, results in decrease in the in vivo bioavailability of first transition series elements and/or removal from the body of first transition series elements and elements with similar chemical properties. These characteristics make such compounds useful in the management of diseases associated with a bodily excess of first transition series elements and elements with similar chemical properties. This invention demonstrates that such compounds inhibit mammalian, bacterial, and fungal cell replication and are therefore useful in the treatment of neoplasia, infection, inflammation, immune reponse, and in termination of pregnancy.
Type:
Grant
Filed:
November 30, 2001
Date of Patent:
June 24, 2003
Assignee:
Chelator LLC
Inventors:
Harry S Winchell, Joseph Y Klein, Elliot D Simhon, Rosa L Cyjon, Ofer Klein, Haim Zaklad
Abstract: The invention provides modifiers for the anionic polymerization of conjugated dienes or of conjugated dienes with vinylaromatic compounds, wherein the modifiers are specific aminoethers.
Type:
Grant
Filed:
November 6, 2001
Date of Patent:
June 24, 2003
Assignee:
Bayer Aktiengesellschaft
Inventors:
Michael Grün, Thomas Knauf, Wilfried Braubach
Abstract: Optically active &agr;-hydroxyethers are prepared from prochiral &agr;-ketoethers by heterogeneous hydrogenation using platinum catalysts in the presence of a chiral nitrogen base in high chemical and optical yields, since this type of hydrogenation selectively hydrogenates only one diastereomer virtually to completion. The yields may be substantially increased by adding a solid, strong base which has a racemizing effect on the non-hydrogenatable diasteromer.
Abstract: The present invention relates to an antitumor agent containing a phytosphingosine derivative, and more specifically, to an antitumor agent containing a phytosphingosine derivative of formula I as an active ingredient,
wherein R1, R2 and R3 respectively represents a hydrogen atom or a C1-C8 alkyl group; and X represents an atom or an atomic group containing a halogen atom, a hydroxyl group, an alkyl sulfonate group or an aryl sulfonate group.
Abstract: A process for preparing optically active secondary alcohols of the general formula (3), [wherein R1 is linear lower alkyl, an aromatic ring group, or the like; A is CH2NR2R3 or the like; n is an integer of 0 to 2; and * represents an asymmetric carbon atom] by asymmetrically hydrogenating a ketone compound of the general formula (1) having nitrogenous or oxygen functional group at any of the a-, &bgr;- and &ggr;-positions, with selectivity among functional groups by the use of a ruthenium/optically active bidentate phosphine/diamine complex as the catalyst in the presence of hydrogen alone or together with a base. The optically active secondary alcohols obtained by the process are useful as drugs and intermediates for the preparation of drugs.
Type:
Application
Filed:
August 6, 2002
Publication date:
March 6, 2003
Inventors:
Seiji Nakano, Ryoji Noyori, Takeshi Ohkuma, Dai Ishii
Abstract: The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula I: 1
Type:
Application
Filed:
July 3, 2002
Publication date:
February 27, 2003
Applicant:
Pharm-Eco Laboratories, Inc.
Inventors:
Richard L. Gabriel, Adel M. Moussa, Sharon Fitzhenry, Changhua Liu, David A. Swanson, Brittany Le, Salah Zahr, Yesh P. Sachdeva, Jurjus Jurayj
Abstract: A fuel oil detergent which efficiently constricts precipitate formation and octane number requirement increase in a carburetor, injector, and inlet system of an internal combustion engine, i.e., a hydropoly(oxyalkylene) oxyalkyl amine based compound, a process for preparing the compound, and a fuel oil composition including the compound.
Abstract: The present invention provides novel cationic amphiphiles containing novel N-hydroxyalkyl group and therapeutic formulations containing the said amphiphiles that are capable of facilitating transport of biologically active molecules into cells.
Type:
Grant
Filed:
January 11, 2002
Date of Patent:
January 7, 2003
Assignee:
Council of Scientific & Industrial Research
Abstract: The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.
Abstract: Medicinal compositions which can be processed into solutions and are useful in inhibiting rejection reactions against the transplantation of organs or bone marrow, in the maintenance immunotherapy therefor or in treating autoimmune diseases, characterized by containing 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or pharmaceutically acceptable acid-addition salts thereof and cyclodextrins as a stabilizer optionally together with saccharides, if required.
Abstract: The present invention is related to a series of derivatives of novel ether diamine compounds prepared by the cyanobutylation reaction of an alcohol having 3 to 22 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and or acrylonitrile and in a subsequent step, hydrogenated to yield a diamine. Specifically, the present invention deals with two types of tertiary amines one made by the reaction of novel ether diamines compounds with ethylene oxide, propylene oxide or butylene oxide or mixtures thereof, producing alkoxylated tertiary amines and the other made by the reaction of novel ether amine compounds with formaldehyde and hydrogen producing methylated tertiary amines. The invention also disclosed novel amine oxides, and quaternary compounds made from said tertiary amines.
Type:
Grant
Filed:
November 27, 2000
Date of Patent:
October 1, 2002
Assignee:
Nova Molecular Technologies INC
Inventors:
Thomas J. Daly, Michael Clumpner, Anthony J. O'Lenick, Jr.
Abstract: Provided herein are catalyst systems useful for providing polyurethane foam products which exhibit low fogging characteristics while possessing favorable overall physical properties when used as interior components of automobiles and other motorized vehicles.
Type:
Grant
Filed:
January 7, 2002
Date of Patent:
October 1, 2002
Assignee:
Huntsman Petrochemical Corporation
Inventors:
Heiko H. Humbert, Robert Allison Grigsby, Jr.
Abstract: The invention discloses stable diesters of chelating agents of divalent metal ions, processes for their preparation and pharmaceutical compositions thereof. Most preferred compounds according to the present invention are stable lipophilic diesters comprising a covalent conjugate of a BAPTA and a pharmaceutically acceptable alcohol. The diesters are useful in a method for treating a condition or disease related to an excess of divalent metal ions, and in particular for the treatment of a condition or disease related to elevated levels of intracellular calcium ions, such as in brain or cardiac ischemia, stroke, epilepsy, Alzheimer's disease or cardiac arrhythmia and in open heart surgery.
Abstract: The invention provides stabilizer systems for scavenging acid, minimizing hydrolysis, or both in polymer systems. The invention comprises a combination selected from the group consisting of: branched primary amino alcohol and carbodiimide; branched primary amino alcohol and dihydroxy metal compound; carbodiimide and dihydroxy metal compound; carbodiimide, branched primary amino alcohol, and magnesium oxide; branched primary amino alcohol and magnesium oxide; carbodiimide and magnesium oxide; and a combination of branched primary amino alcohol, carbodiimide, and dihydroxy metal compound.
Abstract: The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides.
Abstract: An aqueous phase inhibitor for quenching free radical polymerization comprising a free radical quenching agent having a hydrophilic tail is disclosed, as well as a coating and related methods. In one embodiment, the free radical quenching agent can either be an N-hydroxylamine or an N-nitrosonamine, the hydrophilic tail can be a polyhydric alcohol tail and the inhibitor can be a concentrate in a liquid medium such as water, alcohol and mixture thereof.
Abstract: The present invention relates to a process for preparing a catalyst by activating a catalytic composition which comprises
a) at least one metal of group IB or IIB or a compound thereof,
b) where appropriate a carrier
which comprises treating the composition with an alkyne of the general formula I
R1—C≡C—R2 (I)
in which
R1 is alkyl, cycloalkyl, aryl, hydroxyalkyl, haloalkyl, alkoxy or alkoxyalkyl,
R2 is a hydrogen atom, alkyl, cycloalkyl or aryl, and a carbonyl compound of the general formula II
in which
R3 and R4 are, independently of one another, a hydrogen atom, alkyl, haloalkyl, cycloalkyl or aryl,
to catalysts obtainable by this process, and to alkynylations and aminoalkylations employing these catalysts.
Type:
Grant
Filed:
May 31, 2000
Date of Patent:
February 26, 2002
Assignee:
BASF Aktiengesellschaft
Inventors:
Arnd Böttcher, Jochem Henkelmann, Thomas Preiss, Melanie Brunner
Abstract: An aqueous phase inhibitor for quenching free radical polymerization comprising a free radical quenching agent having a hydrophilic tail is disclosed, as well as a coating and related methods. In one embodiment, the free radical quenching agent can either be an N-hydroxylamine or an N-nitrosonamine, the hydrophilic tail can be a polyhydric alcohol tail and the inhibitor can be a concentrate in a liquid medium such as water, alcohol and mixture thereof.
Abstract: The present invention provides novel cationic amphiphiles containing novel N-hydroxyalkyl group and therapeutic formulations containing the said amphiphiles that are capable of facilitating transport of biologically active molecules into cells.
Type:
Grant
Filed:
March 25, 1999
Date of Patent:
February 12, 2002
Assignee:
Council of Scientific & Industrial Research
Abstract: The invention relates to a process for preparing optically active amino alcohols from optically active amino acids by reducing an optically active amino acid with hydrogen in the presence of a ruthenium-containing catalyst and an acid.
Type:
Grant
Filed:
July 25, 2000
Date of Patent:
October 30, 2001
Assignee:
Bayer Aktiengesellschaft
Inventors:
Stefan Antons, Andreas Schulze Tilling, Erich Wolters
Abstract: Preparation of alkanolamines having improved color quality by treating the alkanolamine with an effective amount of phosphorous acid or hypophosphorous acid or compounds thereof initially at elevated temperature over a period of at least 5 min (step a), and then distilling it in the presence of an effective amount of one of these phosphorus compounds (step b).
Type:
Application
Filed:
March 7, 2001
Publication date:
October 18, 2001
Inventors:
Gunther Ruider, Karl-Heinz Robeta, Johann-Peter Melder, Gerhard Schulz, Frank Gutschoven, Philip Buskens
Abstract: The invention relates to compositions and methods for gelling liquid hydrocarbons by the introduction of certain phosphate esters, a crosslinking agent, and an enhancer. The enhancer of the present invention is preferably an oxyalkylated amine or a blend of an oxyalkylated amine with another amine or a non-nitrogen-containing component. Mixed phosphate esters containing an oxyalkylene group are useful in the practice of the invention. Gel-forming compositions for addition to liquid hydrocarbons, as well as methods for forming fracturing fluids, are encompassed. The present compositions and methods are an improvement in the field of hydrocarbon gelling, e.g., in fracturing formations, by providing more rapid gellation and greater viscosities.
Abstract: The present invention provides discrete-length polyethylene glycol and polyethylene glycol containing compounds and methods for their preparation.
Abstract: Preparation of alkanolamines having improved color quality by treating the alkanolamine with hydrogen in the presence of a hydrogenation catalyst at elevated temperature, by using, as hydrogenation catalyst, a heterogeneous catalyst comprising Re, Ru, Rh, Pd, Os, Ir, Pt and/or Ag and a support material chosen from the group consisting of activated carbon, alpha-aluminum oxide, zirconium dioxide and titanium dioxide, where the catalyst, in the case of activated carbon as support material, has a cutting hardness of at least 10 N, a side crushing strength of at least 30 N or a compressive strength of at least 25 N.
Type:
Grant
Filed:
August 23, 2000
Date of Patent:
September 18, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Günther Ruider, Karl-Heinz Ross, Boris Breitscheidel, Heike Maier, Gerhard Schulz, Sylvia Huber
Abstract: A halogen-free hydroxypolyalkene amine composition and a process for production thereof is disclosed. The halogen-free composition is made by epoxidizing polyalkene to form an epoxy intermediate which is subsequently reacted with an excess of an amine compound. Generally, the end product composition contains a plurality of different types of hydroxypolyalkene amines. Such compositions are useful as deposit-control fuel additives.
Type:
Grant
Filed:
November 26, 1997
Date of Patent:
July 17, 2001
Assignee:
Ferro Corporation
Inventors:
James L. Dever, Larry J. Baldwin, Cyril J. Yaggi
Abstract: This invention is directed to an improved process for the preparation of N-(phosphonomethyl)glycine (i.e., “glyphosate”), a salt of N-(phosphonomethyl)glycine, or an ester of N-(phosphonomethyl)glycine. The process comprises combining an N-substituted N-(phosphonomethyl)glycine reactant with oxygen in the presence of a noble metal catalyst. The N-substituted N-(phosphonomethyl)glycine reactant has formula (V):
wherein R1 and R2 are independently selected from the group consisting of hydrogen, halogen, —PO3R12R131, —SO3R14, —NO2, hydrocarbyl, and substituted hydrocarbyl other than —CO2R15; and R7, R8, R9, R12, R13, R14, and R15 are independently selected from the group consisting of hydrogen, hydrocarbyl, substituted hydrocarbyl, and an agronomically acceptable cation.
Type:
Grant
Filed:
March 5, 1999
Date of Patent:
May 15, 2001
Assignee:
Monsanto Company
Inventors:
David A. Morgenstern, David E. McKenzie, Robert Orth, David Oburn, Cindy Ludwig, Kam-to Wan, John M. Dzenitis
Abstract: Alkanolamines of the formula
R—NHCH2CH(OH)CH2CH3 (I)
or mixtures thereof wherein R is H, —CH2CH(OH)CH2CH3, an alkyl group having from 1 to 6 carbon atoms, an aryl group having from 6 to 12 carbon atoms, an aralkyl group having from 6 to 12 carbon atoms, or a cycloalkyl group having from 3 to 6 carbon atoms in combination with a tertiary alkano/amine are effective in the removal of acidic gases from a fluid stream containing same and show superior degradation properties as compared to alkanolamines conventionally used in the gas purification applications.
Abstract: The disclosure involves a novel amine ether acid salt surfactant. The amine constituent of the surfactant may include ether amines or fatty-based amines. The ether acid constituent of the surfactant, in particular, imparts liquidity to the surfactant. Hydrophobic regions may be included on both the amine and ether acid enhancing the surfactancy of the composition. The novel surfactant is versatile and is useful in many different applications.
Abstract: The present invention provides a process for reducing carbonyl compounds to hydroxy compounds, in particular stereoselectively reducing .alpha.-aminohaloketone derivatives, under mild conditions in an easy and simple manner, which comprises reacting a carbonyl compound of the general formula (1) with an organoaluminum compound of the general formula (4) to provide the corresponding alcohol compound of the general formula (5).
Type:
Grant
Filed:
December 29, 1997
Date of Patent:
November 21, 2000
Assignee:
Kaneka Corporation
Inventors:
Tadashi Sugawa, Tadashi Moroshima, Kenji Inoue, Kazunori Kan
Abstract: The present invention relates to a series of novel ether amine compounds prepared by the cyanobutylation reaction of an alcohol having 12 to 26 carbon atoms with 2-pentenenitrile to form a branched alkyl ether nitrile. The etheraminonitriles formed by the process are hydrogenated to form alkylether amines. The resulting product can be reacted with 2-pentenenitrile and hydrogenated to yield a polyamine.
Type:
Grant
Filed:
December 13, 1999
Date of Patent:
September 5, 2000
Assignee:
Nova Molecular Technologies Inc
Inventors:
Thomas J. Daly, Anita Mokadam Sorhaug, Robert E. Harbour, Jr., Abraham A. Zahand, Michael Clumpner, Anthony J. O'Lenick, Jr.
Abstract: The subject-matter of the present invention is a process of use in perfluoroalkylation and a reactant for making use of this process. This process is defined in that it comprises a stage in which a material of formula RfH and a base (or a species capable of generating a base) are brought into contact, in a polar and anhydrous medium, with a substrate carrying at least one electrophilic functional group. Application to organic synthesis.
Abstract: The present invention relates to a catalyst based on titanosilicalites having a content by weight of alkali metal or metals of between 0.05 and 2%. The subject of the invention is more particularly a process for producing N,N-disubstituted hydroxylamine from hydrogen peroxide and the corresponding disubstituted amine.
Abstract: The present invention describes a stereospecific process for the isomerization of prochiral allyl amines into chiral enamines and imines, using Rh, Ir or Ru catalysts which carry chiral phosphine ligands derived from ferrocenes, which may be immobilized on a solid carrier, or from steroides. The process is in particular appropriate for the production of chiral citronellal, which can be obtained in optical purities of greater than 95%.
Abstract: A method for preparing aminoethylethanolamine, and/or hydroxyethylpiperazine is described. Reaction of ethylene oxide with ethylendiamine, piperazine, or a mixture of both produces these compounds.
Abstract: A cytokine activity enhancer comprising an ethanolamine derivative of the following general formula (I) or a salt thereof, or comprising it along with cytokine or a cytokine production promoter; and also a medicine for diseases with lowered cytokine activity, comprising, as the active ingredient, the cytokine activity enhancer: ##STR1## wherein R.sub.1 is H, --CH.sub.3, --CH.sub.2 CH(CH.sub.3)OH or --CH.sub.2 CH.sub.2 OH; R.sub.2 is H, --CH.sub.3, --CH.sub.2 CH.sub.3 or --COOH; and R.sub.3 is H, --CH.sub.3, --CH.sub.2 CH.sub.3 or --CH.sub.2 NH.sub.2.
Abstract: The subject of the invention is a process for the preparation of 2-aminoalkane-1,3,4-triols, in a single stage, preferably a single reduction state, from alkyl 2-hydroxyimino-3-oxo-4-acyloxyalkanoates. The invention makes possible a significant reduction in the number of stages and a marked improvement in the synthesis yields.
Type:
Grant
Filed:
October 15, 1996
Date of Patent:
November 30, 1999
Assignee:
L'Oreal
Inventors:
Didier Semeria, Bernadette Luppi, Michel Philippe
Abstract: Reaction products of polyolefins having predominantly a terminal double bond and a number average molecular weight of from 250 to 10,000, which possess an aliphatic hydrocarbon skeleton which is straight-chain or carries C.sub.1 -C.sub.4 -alkyl side chains, with from 1 to 10 mol, per equivalent of double bond, of one or more vinyl esters I ##STR1## are obtainable by reacting the stated polyolefins with the vinyl esters I in the presence of a free radical initiator at from 80 to 200.degree. C., it being possible for these reaction products subsequently to have been hydrolyzed to the corresponding alcohols or converted into the corresponding amines by reductive amination with amines II ##STR2## .
Type:
Grant
Filed:
July 20, 1995
Date of Patent:
November 2, 1999
Assignee:
BASF Aktiengesellschaft
Inventors:
Hans Peter Rath, Helmut Mach, Harald Schwahn, Hans-Joachim Muller, Wolfgang Reif, Thomas Ruhl