Plural Sulfonamide Groups Containing Or Containing Plural Sulfonyls Bonded Directly To The Same Nitrogen Patents (Class 564/82)
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Patent number: 11618687Abstract: The present invention relates to a method for preparing a lithium bis(fluorosulfonyl)imide salt, including a step of dissolving bis(chlorosulfonyl)imide in an organic solvent in a non-glass vessel to prepare a first reaction solution; a step of injecting lithium fluoride (LiF) to the first reaction solution in the non-glass vessel and refluxing while heating to prepare a second reaction solution; a step of separating a product including a lithium bis(fluorosulfonyl)imide salt and the organic solvent from the second reaction solution; and a step of obtaining the lithium bis(fluorosulfonyl)imide salt in a solid phase from the product, wherein the organic solvent is at least one or more selected from the group consisting of ethyl acetate, butyl acetate, chloroform, dichloromethane, dichloroethane, benzene, xylene and acetonitrile.Type: GrantFiled: April 9, 2019Date of Patent: April 4, 2023Inventors: Byung Soo Kang, Hyun Jik Lee, Won Jae Lee, Chui Haeng Lee, Young Min Lim
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Patent number: 9963473Abstract: The present invention provides a stabilized form of Tetrofosmin, which is stable at room temperature as well as in contact with oxygen, and a non-radioactive kit containing a stabilized form of Tetrofosmin for the preparation of a radiopharmaceutical composition in the field of diagnostic radiopharmaceuticals, especially for myocardial perfusion studies in patients with coronary artery diseases and in oncology.Type: GrantFiled: January 28, 2015Date of Patent: May 8, 2018Assignee: ROTOP Pharmaka GmbHInventor: Eik Schiller
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Patent number: 9328125Abstract: Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMPA receptors.Type: GrantFiled: September 1, 2014Date of Patent: May 3, 2016Assignee: The Board of Regents of the University of Texas SystemInventors: Jia Zhou, Haijun Chen, Kenneth M Johnson, Cheng Z Wang
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Patent number: 9284268Abstract: The invention provides a method for producing fluorotrifluoromethylsulfonyl imide (FTFSI) by reacting non-fluorohalogenated trihalomethylsulfonyl imide (XTXSI) with hydrogen fluoride, where each X is independently a nonfluoro-halide, such as Cl, Br, or I.Type: GrantFiled: November 4, 2013Date of Patent: March 15, 2016Assignee: CoorsTek Fluorochemicals, Inc.Inventors: Joseph Carl Poshusta, Jerry Lynn Martin, Rajendra P. Singh
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Publication number: 20150126778Abstract: The invention provides a method for producing fluorotrifluoromethylsulfonyl imide (FTFSI) by reacting non-fluorohalogenated trihalomethylsulfonyl imide (XTXSI) with hydrogen fluoride, where each X is independently a nonfluoro-halide, such as Cl, Br, or I.Type: ApplicationFiled: November 4, 2013Publication date: May 7, 2015Applicant: Boulder Ionics CorporationInventors: Joseph Carl Poshusta, Jerry Lynn Martin, Rajendra P. Singh
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Patent number: 9023579Abstract: According to one embodiment, an actinic-ray- or radiation-sensitive resin composition includes any of the compounds (A) of general formula (I) below that when exposed to actinic rays or radiation, generates an acid and a resin (B) whose rate of dissolution into an alkali developer is increased by the action of an acid. (The characters used in general formula (I) have the meanings mentioned in the description.Type: GrantFiled: May 31, 2012Date of Patent: May 5, 2015Assignee: FUJIFILM CorporationInventors: Shuhei Yamaguchi, Akinori Shibuya
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Publication number: 20150105429Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, A, B, C, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.Type: ApplicationFiled: December 18, 2014Publication date: April 16, 2015Applicant: GENENTECH, INC.Inventors: Benjamin Fauber, Olivier Rene
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Patent number: 9000045Abstract: The invention provides a compound that is a CETP activity inhibitor. The compound can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity. the invention also provides for the use of the compound to prevent or treat atherosclerosis or hyperlipidemia.Type: GrantFiled: March 21, 2012Date of Patent: April 7, 2015Assignee: Japan Tobacco Inc.Inventors: Hisashi Shinkai, Kimiya Maeda, Hiroshi Okamoto
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Patent number: 9000216Abstract: An optically active spirolactone compound is highly enantioselectively produced by using an iodoarene derivative which can be synthesized easily and which is not racemized easily. A hypervalent iodine compound precursor (iodoarene derivative) which was able to be designed flexibly was synthesized from 2,6-dihydroxyiodoarene by using 1,2-aminoalcohol as a chiral source in short steps, a hypervalent iodine compound was prepared in a reaction system (in situ) by using a catalyst quantity of the resulting precursor in the presence of a stoichiometric quantity of m-CPBA, and a spirolactonization reaction of 3-(1-hydroxy-2-naphthyl)propionic acid was induced. As a result, a corresponding spirolactone compound was obtained at a high enantiomeric excess.Type: GrantFiled: March 6, 2012Date of Patent: April 7, 2015Assignee: National University Corporation Nagoya UniversityInventors: Kazuaki Ishihara, Muhammet Uyanik, Takeshi Yasui
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Patent number: 8962233Abstract: According to one embodiment, an actinic-ray- or radiation-sensitive resin composition includes an arylsulfonium salt that when exposed to actinic rays or radiation, generates an acid, the arylsulfonium salt containing at least one aryl ring on which there are a total of one or more electron donating groups, the acid generated upon exposure to actinic rays or radiation having a volume of 240 ?3 or greater.Type: GrantFiled: January 28, 2011Date of Patent: February 24, 2015Assignee: FUJIFILM CorporationInventors: Takeshi Kawabata, Tomotaka Tsuchimura, Takayuki Ito
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Publication number: 20150045266Abstract: A composition including an ionic liquid alkyl ammonium salt (e.g., tetraalkylammonium cation and bis(trifluoromethanesulfonyl)imide anion) or an ionic liquid imidazolium salt (e.g., 1,3-dialkylimidazolium cation and bis(trifluoromethanesulfonyl)imide anion), that have a structure sufficient to exhibit at least partial solubility in one or more Group I-V base stocks. The disclosure also relates to a lubricating oil base stock and lubricating oil containing the composition, a multifunctional functional fluid containing the composition, and a method for improving solubility of an ionic liquid in a lubricating oil by using as the lubricating oil a formulated oil including a lubricating oil base stock as a major component, and an ionic liquid alkylammonium salt cobase stock, or an ionic liquid imidazolium salt cobase stock, as a minor component.Type: ApplicationFiled: November 14, 2013Publication date: February 12, 2015Applicant: ExxonMobil Research and Engineering CompanyInventors: Abhimanyu Onkar Patil, Satish Bodige, Tezcan Guney
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Publication number: 20140377875Abstract: UV-Absorbing and fluorescent pl markers for isoelectric focusing separations and fluorescent labeling, and methods for making and using the markers.Type: ApplicationFiled: August 27, 2012Publication date: December 25, 2014Applicant: THE TEXAS A&M UNIVERSITY SYSTEMInventors: Gyula Vigh, Ming-Chien Li
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Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism
Publication number: 20140343321Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.Type: ApplicationFiled: May 21, 2014Publication date: November 20, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Daniel A. Lawrence, Dudley Strickland, Jacqueline Cale, Enming Joe Su, Cory Emal, Mark Warnock -
Patent number: 8877969Abstract: A photosensitive composition comprising: (A) a compound capable of generating a compound having a specific structure upon irradiation with actinic rays or radiation, a pattern forming method using the photosensitive composition, and a compound capable of generating a compound having a specific structure upon irradiation with actinic rays or radiation.Type: GrantFiled: April 13, 2010Date of Patent: November 4, 2014Assignee: FUJIFILM CorporationInventor: Kenji Wada
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Patent number: 8853448Abstract: The invention relates to a process for preparing aromatic sulfonylimides, to the sulfonylimides obtained, and to the use thereof as salt of an electrolyte. The sulfonylimides correspond to the formula [R—SO2—N—SO2R?]rM (I). R? is an ArZL- group. R? is a perfluoroalkyl group or an ArZL- group. Z is an S, SO or SO2 group. L is a —(CF2)n—CFRf— group. n is 0 or 1; Rf represents F or a C1 to C8 perfluoroalkyl group; Ar is an aromatic group. M represents H, an alkali metal cation, an alkaline earth metal cation, a trivalent or tetravalent metal cation, or an organic cation. The process consists in preparing a compound RSO2N(R?)SO2R? from RSO2F, and in replacing the group R? by nucleophilic substitution reaction so as to obtain the compound (I), R? being a benzyl or trimethylsilyl group.Type: GrantFiled: July 17, 2007Date of Patent: October 7, 2014Assignees: Institut National Polytechnique de Grenoble, Eras-Labo, Universite Claude Bernard LyonInventors: Jean-Yves Sanchez, Bernard Langlois, Maurice Medebielle, Fabien Toulgoat, Fannie Alloin, Elie Paillard, Cristina Iojoiu
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Publication number: 20140255850Abstract: A method for fabricating a semiconductor product includes applying a photo-resist layer to a substrate, the photo-resist layer including a higher acid concentration at an upper portion of the photo-resist layer than at a lower portion of the photo-resist layer. The method also includes exposing the photo-resist layer to a light source through a mask including a feature, the photo-resist layer including a floating, diffusing acid that will diffuse into a region of the photo-resist layer affected by the feature while not diffusing into a feature formed by the mask.Type: ApplicationFiled: March 9, 2013Publication date: September 11, 2014Applicant: Taiwan Semiconductor Manufacturing Company, Ltd.Inventors: Ching-Yu Chang, Ming-Feng Shieh, Wen-Hung Tseng
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Patent number: 8808961Abstract: An embodiment of the composition contains any of compounds of the formula A-LG in which A represents any of residues of general formula (A-1) below and LG represents any of groups that are cleaved to generate acids of the formula A-H when acted on by an acid. The composition further contains at least one of a compound that generates an acid when exposed to actinic rays or radiation and a compound that generates an acid when heated.Type: GrantFiled: October 28, 2010Date of Patent: August 19, 2014Assignee: FUJIFILM CorporationInventors: Tomotaka Tsuchimura, Takeshi Kawabata, Takayuki Ito
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Publication number: 20140212772Abstract: Provided is an electrolyte solution capable of further increasing the output of a lithium air battery, the electrolyte solution for a lithium air battery having a total bonding strength between Li2O2 is no less than 0.14.Type: ApplicationFiled: June 15, 2012Publication date: July 31, 2014Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Hirofumi Nakamoto, Taishi Shiotsuki, Atsushi Shirasawa, Yushi Suzuki
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Publication number: 20140178773Abstract: A magnesium compound represented by Formula 1 wherein the magnesium compound is dissolvable in an ether solvent, an electrolyte solution for magnesium batteries that includes the magnesium compound and a magnesium battery including the electrolyte solution are provided: wherein, in Formula 1, X1 is a halogen atom; and at least one of X2 and X3 each independently is an electron withdrawing group, wherein, when X2 or X3 is not an electron withdrawing group, X2 or X3 is a hydrogen atom, a C1-C20 alkyl group, or a C6-C20 aryl group.Type: ApplicationFiled: July 12, 2013Publication date: June 26, 2014Inventors: Young-gyoon RYU, Seok-soo LEE, Myung-jin LEE
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Patent number: 8759578Abstract: With this method for manufacturing fluorine-containing imide compounds, a method for manufacturing a fluorine-containing imide compound ((Rf1SO2)(Rf2SO2)NH) is selected which includes reaction of a fluorine-containing sulfonic acid (Rf1SO3H) and a fluorine-containing sulfonamide (Rf2SO2NH) in the presence of thionyl chloride. Wherein, Rf1 and Rf2 are fluorine, or straight-chain or branched perfluoroalkyl groups with a carbon number of 1-4.Type: GrantFiled: May 25, 2011Date of Patent: June 24, 2014Assignees: Mitsubishi Materials Corporation, Mitsubishi Materials Electronic Chemicals Co., Ltd.Inventors: Tsunetoshi Honda, Noriaki Matsumura
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Publication number: 20140163110Abstract: Compounds of the formula Ia or Ib: or pharmaceutically acceptable salts thereof, wherein m, n, r, A, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.Type: ApplicationFiled: December 10, 2013Publication date: June 12, 2014Applicant: GENENTECH, INC.Inventors: Benjamin Fauber, Olivier Rene, Monique Bodil van Niel, Stuart Ward
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Publication number: 20140154588Abstract: A method for preparing an ionic liquid nanoscale ionic material, the ionic liquid nanoscale ionic material and a battery that includes a battery electrolyte that comprises the ionic liquid nanoscale ionic material each provide superior performance. The superior performance may be manifested within the context of inhibited lithium dendrite formation.Type: ApplicationFiled: July 10, 2012Publication date: June 5, 2014Applicant: CORNELL UNIVERSITYInventors: Lynden A. Archer, Surya S. Moganty, Yingying Lu
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Patent number: 8729138Abstract: The present invention relates to a mixture of polyfluoroalkylsulfonamido alkyl amines including at least one polyfluoroalkylsulfonamido alkyl amine and its analog, a di(polyfluoroalkylsulfonamido alkyl)amine. The invention also relates to polyfluoroalkylsulfonamido alkyl halide intermediate used to make the aforementioned mixture.Type: GrantFiled: March 15, 2011Date of Patent: May 20, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Alexander Borisovich Shtarov, Volodymyr B. Pashovych
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Patent number: 8722005Abstract: The invention provides a method for producing hydrogen bis(fluorosulfonyl)imide (HFSI) by reacting hydrogen bis(halosulfonyl)imide (HXSI) with hydrogen fluoride, where each X is independently a nonfluoro-halide, such as Cl, Br, or I.Type: GrantFiled: July 26, 2013Date of Patent: May 13, 2014Assignee: Boulder Ionics CorporationInventors: Joseph Carl Poshusta, Jerry Lynn Martin, Rajendra P. Singh
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Patent number: 8685616Abstract: The present invention provides photoacid generators for use in chemically amplified resists and lithographic processes using the same.Type: GrantFiled: June 10, 2009Date of Patent: April 1, 2014Assignee: University Of North Carolina At CharlotteInventors: Kenneth E. Gonsalves, Mingxing Wang
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Publication number: 20140004428Abstract: An ionic liquid increases power density and discharge capacity in an air battery. Also, to provide a liquid electrolyte for lithium air batteries and an air battery, both of which include the ionic liquid. The ionic liquid for air batteries in which the cation has a structure represented by the following general formulae (1), (2) or (3): wherein R1 to R4 are independent of each other, and R1 to R4 are each an aliphatic hydrocarbon group having 1 to 8 carbon atoms, or the like; wherein R5 to R7 are independent of each other, and R5 to R7 are each an aliphatic hydrocarbon group having 1 to 8 carbon atoms, or the like; wherein R8 to R10 are independent of each other, and R8 to R10 are each an aliphatic hydrocarbon group having 1 to 8 carbon atoms, or the like.Type: ApplicationFiled: June 13, 2013Publication date: January 2, 2014Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventor: Hirofumi NAKAMOTO
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Publication number: 20130338364Abstract: An optically active spirolactone compound is highly enantioselectively produced by using an iodoarene derivative which can be synthesized easily and which is not racemized easily. A hypervalent iodine compound precursor (iodoarene derivative) which was able to be designed flexibly was synthesized from 2,6-dihydroxyiodoarene by using 1,2-aminoalcohol as a chiral source in short steps, a hypervalent iodine compound was prepared in a reaction system (in situ) by using a catalyst quantity of the resulting precursor in the presence of a stoichiometric quantity of m-CPBA, and a spirolactonization reaction of 3-(1-hydroxy-2-naphthyl)propionic acid was induced. As a result, a corresponding spirolactone compound was obtained at a high enantiomeric excess.Type: ApplicationFiled: March 6, 2012Publication date: December 19, 2013Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Kazuaki Ishihara, Muhammet Uyanik, Takeshi Yasui
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Publication number: 20130331609Abstract: A compound [II] such as ammonium N,N-di(fluorosulfonyl)imide is obtained by reacting a compound [I] such as N,N-di(chlorosulfonyl)imide and NH4F (HF)p. A compound [IV] such as an N,N-di(fluorosulfonyl)imide alkali metal salt is obtained by reacting the obtained compound [II] and an alkali metal compound or the like.Type: ApplicationFiled: February 24, 2012Publication date: December 12, 2013Applicant: NIPPON SODA CO., LTD.Inventors: Shiro Tsubokura, Yasuyuki Aiura, Toru Suzuki, Michiaki Maruyama
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Patent number: 8541410Abstract: The present invention relates to compounds of the formula I wherein A1, A2, R1, R2, R3, X and n are as defined in the claims, which are valuable pharmaceutically active compounds for the therapy and prophylaxis of diseases, for example of cardiovascular diseases such as hypertension, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of the formula I are capable of modulating the body's production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of the formula I.Type: GrantFiled: January 6, 2012Date of Patent: September 24, 2013Assignee: Sanofi-aventis Deutschland GmbHInventors: Ursula Schindler, Karl Schönafinger, Hartmut Strobel
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Patent number: 8501992Abstract: The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compounds and methods of treating diseases using the compounds.Type: GrantFiled: June 8, 2009Date of Patent: August 6, 2013Assignee: Bristol-Myers Squibb CompanyInventors: Kyoung S. Kim, Robert M. Borzilleri, Zhen-Wei Cai, Kap-Sun Yeung
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Publication number: 20130190356Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, A, B, C, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.Type: ApplicationFiled: December 18, 2012Publication date: July 25, 2013Applicant: GENENTECH, INC.Inventor: Genetech, Inc.
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Publication number: 20130172388Abstract: Cannabionid receptor-2 inverse antagonists include compounds represented by Formula IV, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 are independently H, alkyl, or alkenyl; R3 is alkyl, alkenyl, aryl, aralkyl, aralkenyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl; R4 and R5 are independently a bond, alkylenyl, or alkenylenyl; each R6 and R7 is independently selected from the group consisting of OH, F, Cl, Br, I, (C1-C6)alkyl, alkoxy, amino, COOH, CONH2, SO3H, PO3H2, CN, SH, NO2 and CF3; and p and q are independently 0, 1, 2, 3, 4, or 5. Such compounds may be used to treat osteoporosis or multiple myeloma.Type: ApplicationFiled: December 14, 2012Publication date: July 4, 2013Applicant: University of Pittsburgh -- Of the Commonwealth System of Higher EducationInventor: University of Pittsburgh -- Of the Commonwealth System of Higher Education
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Publication number: 20130066110Abstract: With this method for manufacturing fluorine-containing imide compounds, a method for manufacturing a fluorine-containing imide compound ((Rf1SO2)(Rf2SO2)NH) is selected which includes reaction of a fluorine-containing sulfonic acid (Rf1SO3H) and a fluorine-containing sulfonamide (Rf2SO2NH) in the presence of thionyl chloride. Wherein, Rf1 and Rf2 are fluorine, or straight-chain or branched perfluoroalkyl groups with a carbon number of 1-4.Type: ApplicationFiled: May 25, 2011Publication date: March 14, 2013Applicant: MITSUBISHI MATERIALS CORPORATIONInventors: Tsunetoshi Honda, Noriaki Matsumura
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Publication number: 20130053417Abstract: The invention provides a compound that is a CETP activity inhibitor. The compound can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity, the invention also provides for the use of the compound to prevent or treat atherosclerosis or hyperlipidemia.Type: ApplicationFiled: March 21, 2012Publication date: February 28, 2013Applicant: JAPAN TOBACCO INC.Inventors: Hisashi Shinkai, Kimiya Maeda, Hiroshi Okamoto
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Publication number: 20130037753Abstract: Disclosed is an organic electronic material comprising charge transporting compounds and ionic compounds having electron-accepting properties and high solubility in a solvent. The organic electronic material is characterized by comprising charge transporting compounds and ionic compounds, and in that at least one of the ionic compounds is any one kind of compounds represented by general formulas (1b)-(3b). (In the formulas Y1-Y6 each independently represent a divalent linking group, R1-R6 each independently represent an electron-attracting organic substituent (these structures can further have substituents and hetero-atoms, and R1, R2 and R3, or, R4-R6 can respectively combine and become a ring shape or a polymer shape) and L+ represents a monovalent cation.Type: ApplicationFiled: April 20, 2011Publication date: February 14, 2013Applicant: HITACHI CHEMICAL COMPANY, LTDInventors: Kenichi Ishitsuka, Shigeaki Funyuu, Yousuke Hoshi
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Publication number: 20120272462Abstract: The present invention relates to a compound of formula (I), where X, Y, T and Z are each as defined in claim 1, to its preparation and to its use.Type: ApplicationFiled: January 17, 2012Publication date: November 1, 2012Applicant: DyStar Colours Deutschland GmbHInventors: Roxana Barbieru, Carsten Harfmann, Werner Russ
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Publication number: 20120269804Abstract: The present invention relates to substituted benzosulphonamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: October 7, 2010Publication date: October 25, 2012Applicant: Bayer Intellectual Property GmbHInventors: Marion Hitchcock, Ingo Hartung, Florian Pühler
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Publication number: 20120269803Abstract: The present invention relates to substituted benzosulphonamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: October 12, 2010Publication date: October 25, 2012Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Marion Hitchcock, Ingo Hartung, Florian Pühler
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Publication number: 20120237874Abstract: According to one embodiment, an actinic-ray- or radiation-sensitive resin composition includes any of the compounds (A) of general formula (I) below that when exposed to actinic rays or radiation, generates an acid and a resin (B) whose rate of dissolution into an alkali developer is increased by the action of an acid. (The characters used in general formula (I) have the meanings mentioned in the description.Type: ApplicationFiled: May 31, 2012Publication date: September 20, 2012Applicant: FUJIFILM CORPORATIONInventors: Shuhei Yamaguchi, Akinori Shibuya
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Patent number: 8268885Abstract: The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.Type: GrantFiled: September 10, 2004Date of Patent: September 18, 2012Assignee: Janssen R&D IrelandInventors: Koenraad Lodewijk August Van Acker, Piet Tom Bert Paul Wigerinck, Lieve Emma Jan Michiels, Abdellah Tahri
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Publication number: 20120165571Abstract: To provide methods for producing a bis(sulfonyl)imide ammonium salt, a bis(sulfonyl)imide and a bis(sulfonyl)imide lithium salt simply and in good yield. A method for producing a bis(sulfonyl)imide ammonium salt, which comprises reacting a compound of the formula R—CHF—SO2X (wherein R is a C1-4 fluorinated alkyl group which may contain an etheric oxygen atom, or a fluorine atom, and X is a fluorine atom or a chlorine atom) with ammonia in the absence of a catalyst. Further, methods for producing a bis(sulfonyl)imide and a bis(sulfonyl)imide lithium salt by using the bis(sulfonyl)imide ammonium salt.Type: ApplicationFiled: March 1, 2012Publication date: June 28, 2012Applicant: Asahi Glass Company, LimitedInventors: Ryuji SEKI, Shouji FURUTA, Masao IWAYA
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Patent number: 8193184Abstract: Substituted sulphonamides having the general formula (I) and salts, hydrates and solvates thereof were prepared and described, wherein R1 is CO or SO2 and R2 is NH or O and where R represents linear or cyclic aliphatic chain and n represents number of linking aliphatic chain carbons (n can be 0, 1, 2 or 3), which are useful in the manufacture of the medicaments due to the carboanhydrase inhibition. These compounds are prepared by nucleophilic reaction of an amine with 4-sulfamoylbenzenesulphonyl chloride in the presence of triethylamine excess in tetrahydrofurane or in ether at temperature 0 to 20° C. The compounds show an antiglaucomatic activity.Type: GrantFiled: April 20, 2008Date of Patent: June 5, 2012Assignee: Unimed Pharma, SPOL, S.R.O.Inventors: Fridrich Gregan, Milan Remko, Elena Sluciakova, Jarmila Knapikova
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Publication number: 20120083603Abstract: Polyionic liquid salts are provided comprising polycationic or polyanionic molecules. Further provided are solvents comprising one or more polyionic liquid salts, and the use of such polyionic liquid salts as stationary phases in gas chromatography, and as a reagent in electrospray ionization-mass spectrometry (ESI-MS).Type: ApplicationFiled: December 13, 2011Publication date: April 5, 2012Applicant: Sigma-Aldrich Co. LLCInventors: Daniel W. Armstrong, Junmin Huang
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Publication number: 20120053300Abstract: The invention relates to functionalized polysulfide silica coupling agents and silica reinforced rubber compositions. Such rubber composition may be used, for example, for tire components such as, for example, tire treads.Type: ApplicationFiled: July 6, 2011Publication date: March 1, 2012Inventors: Junling Zhao, Michael Joseph Rachita
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Publication number: 20120022269Abstract: According to the method for producing fluorine-containing N-alkylsulfonylimide compound, the fluorine-containing N-alkylsulfonylimide compound can be produced safely with a high recovery rate by alkylating fluorine-containing sulfonylimide acid or fluorine-containing sulfonylimide acid salt with dialkylsulfuric acid or dialkylcarbonic acid.Type: ApplicationFiled: March 31, 2010Publication date: January 26, 2012Applicants: Mitsubishi Materials Electroic Chemicals Co., Ltd., Mitsubishi Materials CorporationInventors: Tsunetoshi Honda, Hiroyuki Yatsuyanagi, Takashi Konishi, Daisuke Takano
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Publication number: 20120000790Abstract: A method and ionic liquid for the electrorecovery of metal from a metal salt including at least one metal ion. The method includes the steps of dissolving the metal salt in an ionic liquid, the ionic liquid including an ionic liquid cation and an ionic liquid anion; whereby the metal ion of the metal salt forms a metal complex in solution with at least the ionic liquid cation; and subjecting the metal complex to an electrical potential between a cathode and anode to recover metal at the cathode. The ionic liquid includes an ionic liquid cation and an ionic liquid anion, wherein the ionic liquid cation has an affinity for the metal ion which is at least about equal to that of the ionic liquid anion for the metal ion.Type: ApplicationFiled: March 17, 2010Publication date: January 5, 2012Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: Theo Rodopoulos, Michael David Horne, Thomas Ruether
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Publication number: 20110294793Abstract: The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compounds and methods of treating diseases using the compounds.Type: ApplicationFiled: June 8, 2009Publication date: December 1, 2011Inventors: kyoung S Kim, Robert M. Borzilleri, Zhen-Wei Cai, Kap-Sun Yeung
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Patent number: 8049026Abstract: Ionic compounds which are liquids at room temperature are formed by the method of mixing a neutral organic ligand with the salt of a metal cation and its conjugate anion. The liquids are hydrophobic, conductive and stable and have uses as solvents and in electrochemical devices.Type: GrantFiled: January 10, 2008Date of Patent: November 1, 2011Assignee: UT-Battelle, LLCInventors: Sheng Dai, Huimin Luo
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Patent number: 8026395Abstract: The present invention relates to simple, safe, high-yield methods of synthesizing VNP40101M, 1,2-bis(methylsulfonyl)-2-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine, an anti-neoplasia agent. One particularly preferred method uses methyl chloroformamide in a one-pot reaction at elevated temperatures to provide VNP40101M in high yield.Type: GrantFiled: May 27, 2009Date of Patent: September 27, 2011Assignee: Nanotherapeutics, Inc.Inventors: Xu Lin, Ivan King
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Publication number: 20110215274Abstract: Ferroelectric liquid crystal compositions including organic ion pair compounds wherein image sticking is reduced or eliminated. Use of the ferroelectric liquid crystal compositions in a ferroelectric liquid crystal display device allows for rapid image refresh rates without required a DC-balancing algorithm. The organic ion pair compounds provide electrical resistivity values for the compositions that result in reduced image sticking when the compositions are used in FLC display devices.Type: ApplicationFiled: January 14, 2011Publication date: September 8, 2011Inventors: Cory Pecinovsky, William Thurmes, Brion C. Koprowski