Plural Sulfonamide Groups Containing Or Containing Plural Sulfonyls Bonded Directly To The Same Nitrogen Patents (Class 564/82)
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Patent number: 5587513Abstract: The present invention relates to novel polyether-substituted compounds of imides and their use as surface-active agents.Type: GrantFiled: January 20, 1995Date of Patent: December 24, 1996Inventors: Klaus Pohmer, Rainer Weber, Cornelia D orzbach-Lange, Reinhard Haida, Hans-Heinrich Moretto
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Patent number: 5559150Abstract: The present invention is directed to novel compounds that are non-peptidic thrombin inhibitors. The compounds have the structure: ##STR1## and pharmaceutically acceptable salts thereof; wherein R.sup.1 is one of alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; and n is from zero to five. The compounds of the invention are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases.Type: GrantFiled: June 6, 1995Date of Patent: September 24, 1996Assignee: 3-Dimensional Pharmaceuticals, Inc.Inventor: Richard M. Soll
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Patent number: 5523484Abstract: An electrophotographic toner having polymeric binder and a charge control agent selected from the group consisting of sulfonamides having the general structure: ##STR1## Each R.sup.1 is independently O, S, N-H, N-R.sup.z, or N-L-R.sup.z ; where L is a linking group selected from: ##STR2## and R.sup.z is independently selected from the group consisting of alkyl having from 1 to 20 carbons, cycloalkyl having from 3 to 18 carbons, and aromatic and heteroaromatic ring systems having a solitary ring or 2 to 3 linked or fused rings. R.sup.a, R.sup.b, and R.sup.c are each independently a ring system of a single ring or 2 or 3 fused or linked rings, said ring system having from 3 to 34 carbons, including substituent carbons. d is an integer from 0 to 3. e is an integer from 0 to 3. The sum of d+e is 2 or 3.Type: GrantFiled: September 30, 1994Date of Patent: June 4, 1996Assignee: Eastman Kodak CompanyInventors: John C. Wilson, Peter S. Alexandrovich
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Patent number: 5502251Abstract: Fluoroalkyl- and fluoroaryl-group-containing imides and their salts of general formula (I) ##STR1## wherein R.sub.F is a fluoroalkyl group with 1 to 18 carbon atoms, a fluoroaryl group with 6 to 12 carbon atoms or a mixed fluoroalkylaryl group with 7 to 18 carbon atoms, wherein the carbon chain can also be interrupted by oxygen atoms,R.sub.H is an alkyl group with 1 to 30 carbon atoms, an aryl group with 6 to 12 carbon atoms or a mixed alkylaryl group with 7 to 30 carbon atoms, wherein the carbon chain of the group can also be interrupted by oxygen, nitrogen or sulphur atoms,Y.sub.1 and Y.sub.2 independently of each other represent a ##STR2## X is a hydrogen cation or a uni- or multivalent cation, m is a whole number from 0 to 6, andz is a whole number from 1 to 7 corresponding to the charge of the cation X.Type: GrantFiled: February 1, 1995Date of Patent: March 26, 1996Assignee: Bayer AGInventors: Klaus Pohmer, Rainer Weber, Cornelia Do/ rzbach-Lange, Karlheinz Stachulla, Hans-Heinrich Moretto, Manfred Wienand
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Patent number: 5463122Abstract: Antibacterial and antiviral phenylthiols and dithiobisbenzamides have the formula ##STR1## where n is 1 or 2, Y is hydrogen when n is 1, and a single bond when n is 2; and R.sup.1 and R.sup.11 are substituent groups, R.sup.4 is hydrogen or alkyl, and Z is hydrogen, alkyl, cycloalkyl or sulfamoylphenyl.Type: GrantFiled: August 5, 1994Date of Patent: October 31, 1995Assignee: Warner-Lambert CompanyInventors: Edward F. Elslager, Rocco D. Gogliotti
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Patent number: 5451677Abstract: Substituted phenylsulfonamides are selective .beta..sub.3 adrenergic receptor agonists with very little .beta..sub.1 and .beta..sub.2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted alkyl epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility are also disclosed.Type: GrantFiled: December 15, 1993Date of Patent: September 19, 1995Assignee: Merck & Co., Inc.Inventors: Michael H. Fisher, Robert J. Mathvink, Hyun O. Ok, Emma R. Parmee, Ann E. Weber
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Patent number: 5414120Abstract: The present invention relates to novel polyether-substituted compounds of imides and their use as surface-active agents.Type: GrantFiled: November 12, 1993Date of Patent: May 9, 1995Assignee: Bayer AGInventors: Klaus Pohmer, Rainer Weber, Cornelia Dorzbach-Lange, Reinhard Haida, Hans-Heinrich Moretto
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Patent number: 5403957Abstract: The present invention relates to a process of preparing N-benzenesulfonimides comprising reacting an alkali metal salt of a sulfonimide with fluorine in the presence of water or water/organic solvent mixtures. N-fluorosulfonimides are useful as fluorinating agents. The N-fluorosulfonimides allow the introduction of fluorine into organic compounds under mild conditions.Type: GrantFiled: October 20, 1992Date of Patent: April 4, 1995Inventors: William J. Wagner, George A. Shia, Andrew J. Poss
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Patent number: 5395486Abstract: Dehydrated compositions are obtained by: combining a hydrous composition, e.g., a hydrous electrolyte salt, with inert fluorochemical liquid; heating the resulting mixture in a vessel to volatilize water and inert fluorochemical liquid therein until the water content of the mixture is reduced to a desired level; optionally treating the resulting dehydrated mixture with another chemical material, e.g., a polar organic solvent; and optionally subjecting the dehydrated mixture or the treated dehydrated mixture to further treatment, e.g., separation of the mixture. Liquid electrolytes suitable for use in battery applications can be prepared by this method.Type: GrantFiled: October 19, 1993Date of Patent: March 7, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventors: Michael E. Killian, John C. Stone
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Patent number: 5391650Abstract: A compound having at least one 2-hydroxy-1,3-propylidene, 2-acetoxy-1,3-propylidene, or 2-alkoxy-1,3-propylidene moiety between two benzocyclobutene end moieties is prepared by (a) contacting a diepoxide species with a benzocyclobutene species containing a functionality capable of reacting with an epoxy group, (b) contacting an epoxy-containing benzocyclobutene species with a species containing two functionalities capable of reacting with an epoxy group, (c) contacting an epoxy-containing benzocyclobutene species with a benzocyclobutene species containing a functionality capable of reacting with an epoxy group, (d) contacting epichlorohydrin with benzocyclobutene species capable of reacting with an epoxy group, or (e) contacting epihalohydrin with benzocyclobutene species and difunctional species, wherein both species contain functionalities capable of reacting with epoxy groups.Type: GrantFiled: December 30, 1992Date of Patent: February 21, 1995Assignee: The Dow Chemical CompanyInventors: David J. Brennan, Jerry E. White, Daniel M. Scheck, Robert A. Kirchhoff, Charles Z. Hotz
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Patent number: 5382595Abstract: A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydroben or an alkyl, X is sulfur or oxygen, R2 and R3 are hydrogen, an substituent such as an alkyl and J is pyridyl or phenyl having substituents and a heterocyclic ring may be formed between R2, R3 and J is provided here and is useful in the pharmacological field.Type: GrantFiled: October 13, 1992Date of Patent: January 17, 1995Assignee: Eisai Co., Ltd.Inventors: Norio Minami, Fumihiro Ozaki, Keiji Ishibashi, Yasuhiro Kabasawa, Megumi Ikemori, Toshiaki Ogawa, Takanori Kawamura
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Patent number: 5348960Abstract: A series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones having enhanced water solubility bioavailability and metabolic stability is disclosed in the Formula I ##STR1## wherein R.sup.1 is H, or C.sub.1 -C.sub.4 lower alkyl;R.sup.2 is H, or (CH.sub.2).sub.m R.sup.3 ;R.sup.3 is tetrahydro-2H-pyranyl, C.sub.1 -C.sub.8 alkyl, C.sub.4 -C.sub.8 cycloalkyl, or substituted or unsubstituted phenyl, wherein the substituents are halogen, alkoxy, or trifluoromethyl;m is an integer of 1-3; andn is an integer of 1-5;or pharmaceutically acceptable salt thereof.The compounds are useful as inhibitors of ADP-induced blood platelet aggregation in human platelet-rich plasma.Type: GrantFiled: August 30, 1993Date of Patent: September 20, 1994Assignee: Bristol-Myers Squibb CompanyInventors: Piyasena Hewawasam, Nicholas A. Meanwell
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Patent number: 5276184Abstract: Adducts containing mesogenic or rodlike moieties are prepared by reacting (1) at least one compound containing an average of more than one vicinal epoxide group per molecule with (2) at least one compound containing an average of more than one reactive hydrogen atom per molecule; with the proviso that at least one member of components (1) and (2) contains a mesogenic or rodlike moiety. These compounds are useful as curing agents for epoxy resins.Type: GrantFiled: August 3, 1990Date of Patent: January 4, 1994Assignee: The Dow Chemical CompanyInventors: Robert E. Hefner, Jr., Jimmy D. Earls
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Patent number: 5256821Abstract: Method for the synthesis of sulfonylimidides having the formula M((RSO.sub.2).sub.2 N).sub.y, wherein M is a metal or an ammonium radical quaternary or not, the Rs, which may be identical or similar are organic monovalent radicals, particularly hydrocarbyles and preferably perfluorohydrocarbyles, in C.sub.1 to C.sub.12, and y is the valence of M. On the one hand, silazane component selected amongst the silazane compounds M(((R.sub.2).sub.3 Si).sub.2 N).sub.y or the associations of a silazane derivative A((R.sub.2).sub.3 Si).sub.2 N or a fluoride M.sub.1 F.sub.z of low cross-linking energy is reacted with, on the other hand, at least one sulfonic halogenite component consisting of a sulfonyl fluoride RSO.sub.2 F or in the association of a sulfonyl chloride RSO.sub.2 Cl with a fluoride M.sub.1 F.sub.z, M, R and y having the above-mentioned significations, M being selected amongst the Ms and being optionally identical to M, z being the valence of M.sub.1 and R.sub.2 representing an alkyl in C.sub.1 to C.sub.4.Type: GrantFiled: January 5, 1993Date of Patent: October 26, 1993Assignees: Societe Nationale Elf Aquitaine, Hydro-QuebecInventor: Michel B. Armand
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Patent number: 5254732Abstract: The invention describes N-fluorosulfonimides which are useful as fluorinating agents. The N-fluorosulfonimides are stable, easily synthesized, and allow the introduction of fluorine into organic compounds under mild conditions.Type: GrantFiled: February 28, 1992Date of Patent: October 19, 1993Assignee: Allied-Signal Inc.Inventor: Edmond Differding
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Patent number: 5241110Abstract: This invention relates to a process for preparing perfluoroalkoxysulphonic compounds having formula: ##STR1## wherein R.sub.f represents a perfluoroalkyl or perfluoroethereal group, X represents F, OH or OM, in which M is an alkaline cation, an alkaline-earth cation, or X represents NR.sub.1 R.sub.2, in which R.sub.1 and R.sub.2, independently of each other, represent H or an alkyl group containing from 1 to 5 carbon atoms and p is a number selected from 1 to 2, characterized in that the perfluoro vinyl sulphonyl fluoride of formula (II) CF.sub.2 =CF--SO.sub.2 F is reacted with a hypofluorite of formula (III):R.sub.f (OF).sub.r (III)wherein R.sub.f is the same as defined above, and r represents 1 or 2, optionally in an inert solvent, at a temperature approximately ranging from -140.degree. C. to +40.degree. C.Type: GrantFiled: July 10, 1991Date of Patent: August 31, 1993Assignee: Ausimont S.p.A.Inventors: Walter Navarrini, Vittorio Montanari, Anna M. Staccione
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Patent number: 5191117Abstract: The sulfonamide derivative according to the present invention is expressed by a general formula: ##STR1## (where R represents an alkyl group. --X represents --L.sub.12 --COOM or ##STR2## and Y-- represents R--SO.sub.2 NH--L.sub.11 -- or MOOC--L.sub.12 --. Each of L.sub.11 and L.sub.12 represents an alkylene group. Z is identical to Y, and M represents a hydrogen atom or a cation. However, X and Y cannot be --L.sub.12 --COOM at the same time. W represents an alkylene group or a cycloalkylene group having 2 or more carbon atoms.)This compound is useful as a metallic ion shielding agent and is suitable, for example, for the applications such as photographic processing solution, chelate titration or analytical reagent for medical treatment or for medical drugs as a metallic ion shielding agent.Type: GrantFiled: December 24, 1991Date of Patent: March 2, 1993Assignee: Fuji Photo Film Co., Ltd.Inventors: Hisashi Okada, Morio Yagihara
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Patent number: 5173105Abstract: An herbicide compound of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, nitro; cyano; C.sub.1 -C.sub.2 haloalkyl, or R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl;R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.1 and R.sup.2 together are alkylene having 2 to 5 carbon atoms;R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.3 and R.sup.4 together are oxo;R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.6 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.5 and R.sup.6 together are alkylene having 2 to 5 carbon atoms;R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n -- wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.Type: GrantFiled: February 5, 1991Date of Patent: December 22, 1992Assignee: Imperial Chemical Industries PlcInventor: Christopher G. Knudsen
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Patent number: 5155271Abstract: The invention relates to a process for the preparation of compounds of the formula ##STR1## in which Q is substituted or unsubstituted C.sub.1 -C.sub.6 alkyl, A is a direct bond or a bridging member, s is the number 1 or 2, Z is a radical of the formula --CH.sub.2 CH.sub.2 OH, --CH.dbd.CH.sub.2 or --CH.sub.2 CH.sub.2 --Y, and Y is a leaving group, and the benzene or napthalene nucleus I can be further substituted, which comprises reacting compounds of the formula ##STR2## with compounds of the formulaQ--OH (3)in which A, s, Z and Q are as defined under formula (1), in the presence of hydrogenation catalysts, and then carrying out further conversion reactions where appropriate.The compounds obtained by the process according to the invention are suitable as intermediates for the preparation of reactive dyes.Type: GrantFiled: June 25, 1990Date of Patent: October 13, 1992Assignee: Ciba-Geigy CorporationInventor: Peter Aeschlimann
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Patent number: 5152826Abstract: An herbicide compound of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, nitro; cyano; C.sub.1 -C.sub.2 haloalkyl, or R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl;R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.1 and R.sup.2 together are alkylene having 2 to 5 carbon atoms;R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.3 and R.sup.4 together are oxo;R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.6 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.5 and R.sup.6 together are alkylene having 2 to 5 carbon atoms;R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n --wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.Type: GrantFiled: October 16, 1991Date of Patent: October 6, 1992Assignee: Imperial Chemical Industries PLCInventor: Christopher G. Knudsen
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Patent number: 5145997Abstract: Poly (alkylene oxide) substituted acetoacetanilides of the formula: ##STR1## wherein B comprises a divalent bridging moiety selected from the group consisting of C.sub.1 -C.sub.6 alkylene, --NHSO.sub.2 --, --O--, --CO--, --COO--, and --NCHO--; X comprises a poly (alkylene oxide) having a number average molecular weight of about 200 to 10,000; R comprises 0 to 4 moieties independently selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and halogen; and d is an integer of 1 to 3. The poly (alkylene oxide) substituted acetoacetanilides are prepared by reacting a poly (alkylene oxide) monoamine, diamine or triamine with isatoic anhydride followed by acetoacetylation of the resultant aminobenzamide. The substituted acetoacetanilides are useful for preparing improved diarylide pigment compositions which in turn are useful for preparing storage stable printing inks (especially of the publication gravure type).Type: GrantFiled: February 12, 1991Date of Patent: September 8, 1992Assignee: Sun Chemical CorporationInventors: Russell J. Schwartz, Anthony C. Zwirgzdas, Terence R. Chamberlain
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Patent number: 5145996Abstract: Heteroatom containing perfluoroalkyl terminated neopentyl mercapto-alcohols of the formulas I and IIHS--[CH.sub.2 C(CH.sub.2 X--E--R.sub.f).sub.2 CH.sub.2 ]--OH (I)HS--[CH.sub.2 C(CH.sub.2 X.sub.1 --R.sub.f).sub.2 CH.sub.2 ]--OH (II)are prepared from the corresponding perfluorinated neopentyl oxetans where R.sub.f is a straight or branched chain perfluoroalkyl of 1 to 18 carbon atoms or said perfluoroalkyl substituted by perfluoroalkoxy of 2 to 6 carbon atoms, E is a linking group, and X and X.sub.1 are heteroatom moieties.The reaction products of these fluorinated mercapto-alcohols with electrophiles are disclosed as are certain functional derivatives. Compositions containing such materials provide improved thermal stability and useful low surface energy oil and water repellent coatings for textiles, glass, paper, leather, and other materials.Type: GrantFiled: February 25, 1991Date of Patent: September 8, 1992Assignee: Ciba-Geigy CorporationInventors: Michael Jacobson, Kirtland P. Clark
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Patent number: 5144072Abstract: This invention provides Class III anti-arrhythmic agents of the formula: ##STR1## in which R.sup.1 is alkylsulfonamido, R.sup.2 is ethyl, R.sup.3 is hydrogen, R.sup.4 is ethyl, and n is 2 to 4, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 21, 1988Date of Patent: September 1, 1992Assignee: American Home Products CorporationInventors: George C. Buzby, Jr., Thomas J. Colatsky
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Patent number: 5105006Abstract: The invention is a novel phosphonium salt, useful as an initiator or catalyst in the reaction of oxirane groups in an epoxy resin with aromatic carbonate and/or ester linkages in monomeric, oligomeric, or polymeric carbonates, esters, or estercarbonates.Type: GrantFiled: May 25, 1989Date of Patent: April 14, 1992Assignee: The Dow Chemical CompanyInventor: Theodore L. Parker
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Patent number: 5101072Abstract: Sulfonylhydrazines of the formula RSO.sub.2 N(CH.sub.2 CH.sub.2 X)N(SO.sub.2 CH.sub.3).sub.2, wherein R is an alkyl or an aryl and X is a halogen or OSO.sub.2 Y, wherein Y is an alkyl or an aryl. Such sulfonylhydrazines are useful in treating cancer.Methylating agents of the formula(a) R'SO.sub.2 N(CH.sub.3)N(SO.sub.2 CH.sub.3).sub.2, wherein R' is an alkyl or an aryl and(b) R"SO.sub.2 N(CH.sub.3)N(CH.sub.3)SO.sub.2 R", wherein R" is an alkyl or an aryl. Such methylating agents are useful as antitrypanosomal and anticancer agents.Type: GrantFiled: September 6, 1989Date of Patent: March 31, 1992Assignee: Yale UniversityInventors: Alan C. Sartorelli, Alan A. Divo, Krishnamurthy Shyam, Philip G. Penketh
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Patent number: 5079248Abstract: A series of [N-alkyl-N-(nitro-, alkylsulphonamido, or amino-phenalkyl) amino]-alkyl, alkoxy or alkylthio phenyl derivatives having utility as anti-arrhythmic agents.Type: GrantFiled: June 20, 1990Date of Patent: January 7, 1992Assignee: Pfizer Inc.Inventors: Peter E. Cross, Geoffrey N. Thomas, John E. Arrowsmith
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Patent number: 5072040Abstract: The invention relates to a process for the synthesis of sulfonylimides.The process for the synthesis of sulfonylimides of the general formula M[RSO.sub.2).sub.2 N].sub.y, in which M represents a metal chosen from alkali metals, alkaline earth metals, rare earths, Al, Sc, Y and Th, R represents a monovalent radical chosen from linear or branched aliphatic radicals having 1 to 8 carbon atoms, alicyclic radicals having 3 to 8 carbon atoms, aryl radicals having 3 to 8 carbon atoms, and y is a number equal to the valence of M, is characterized in that an ionic nitride of the formula M.sub.3 N.sub.y, in which M and y have the meaning given above, is reacted with a sulfonyl halide of the formula RSO.sub.2 X, in which R has the meaning given above, and X is chosen from F or Cl, in an aprotic polar solvent.Type: GrantFiled: December 3, 1990Date of Patent: December 10, 1991Assignees: Centre National de la Recherche Scientifique, Hydro-QuebecInventor: Michel Armand
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Patent number: 5057623Abstract: An organic fluorine compound represented by the general formulaR.sub.f -(X).sub.h -R-Mwherein R.sub.f is a group selected from the following (a) and (b); ##STR1## X denotes a linking group selected from --O--, --S--, and --COO--, h denotes 0 or 1, R is a hydrocarbon chain comprising a phenylene group having an alkylene group with a total carbon number of 10 or more, or the derivative thereof, or an aliphatic alkylene group of a carbon number of 10 or more, and M is a group selected from --OH, --COOH, --SH, and --CONH.sub.2.The organic fluorine compound of the present invention greatly improves the dispersibility of magnetic powders in magnetic coating materials, has also an excellent rust prevention effect on metallic magnetic powders, and exhibits a marked dispersing effect even on fluorocarbon resin fine powders, which can be difficultly dispersed with conventional dispersing agents.Type: GrantFiled: October 13, 1989Date of Patent: October 15, 1991Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Yoshiaki Kai, Takashi Suzuki
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Patent number: 5045632Abstract: The invention is a novel bis(phosphoranylidene) ammonium salt useful as an initiator/catalyst in the reaction of oxirane groups in an epoxy resin with aromatic carbonate and/or ester linkages in monomeric, oligomeric, or polymeric carbonates, esters, or estercarbonates.Type: GrantFiled: December 19, 1990Date of Patent: September 3, 1991Assignee: The Dow Chemical CompanyInventor: Theodore L. Parker
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Patent number: 5006561Abstract: Novel 5-alkanesulphonamido-2-[N-(4-alkanesulphonamidophenoxyalkyl)-N-methylamino ]indane and 5-alkanesulphonamido-2-[N-(4-alkanesulphonamidophenyl-alkyl)-N-methylamino ]indane compounds have been prepared, including their pharmaceutically acceptable salts and various key novel intermediates therefor. These compounds are useful in therapy as anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrhythmias. The most preferred member compouned is 5-methanesulphonamido-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino] indane. Methods for preparing these compounds from known starting materials are provided.Type: GrantFiled: April 17, 1990Date of Patent: April 9, 1991Assignee: Pfizer Inc.Inventors: John E. Arrowsmith, Peter E. Cross
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Patent number: 4992563Abstract: This invention relates to several intermediates useful in preparing thromboxane A.sub.2 inhibiting (.+-.)7-[3.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-1.alpha ., 4.alpha.-bicyclo[2.2.1]hept-2.beta.-yl]-heptenoic acids and useful derivatives thereof from (.+-.)octahydro-1.alpha.-methyl-3a.alpha., 7a.alpha.-4.alpha.,7.alpha.-methano-2H-inden-2-ones.Type: GrantFiled: December 13, 1988Date of Patent: February 12, 1991Assignee: National Research Development CorporationInventors: Robert B. Garland, Masateru Miyano
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Patent number: 4980349Abstract: The invention relates to new compounds corresponding to formula I: ##STR1## in which: W represents C=O, CH.sub.2 or CHOH,Z represents ##STR2## R.sub.1 and R.sub.2 represent especially Cl or F, R, R' and R" represent especially H,X represents especially CH.sub.2,Y represents especially COOH,u and v are two integers ranging from 0 to 10,p and q take the value 0 or 1,n and m are two integers ranging 0 to 10 andt is 0 or 1the total number of carbon atoms in the chain ##STR3## ranging from 2 to 20, and to their physiologically acceptable salts obtained with organic or inorganic acids.These compounds are useful for preparing medicinal products which have, especially, anti-inflammatory properties.Type: GrantFiled: November 12, 1987Date of Patent: December 25, 1990Assignee: SANOFIInventors: Pierre Roger, Jean-Paul Fournier, Alain Martin, Jean Choay
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Patent number: 4959488Abstract: Polyfunctional hexasubstituted benzene derivatives wherein at least three of the substituents are saturated carbon chains having from 1 to 21 carbon atoms and functional groups containing hetero functionalities at the ends of the carbon chains and the remainder of the 6 substituents are either saturated carbon chains containing from 1 to 21 carbon atoms or saturated carbon chains containing from 1 to 21 carbon atoms having a functional group including a hetero functional group containing N, O, S, P, or Si at the end of the chains. These derivatives are made by reacting a disubstituted alkyne wherein one or both of the substituents are saturated carbon chains having 1 to 21 carbon atoms to which hetero functional groups are attached with a palladium catalyst and isolating the resulting hexasubstituted benzene derivative.Type: GrantFiled: May 17, 1989Date of Patent: September 25, 1990Assignee: Henkel Research CorporationInventors: James M. Renga, Alan G. Olivero, Mark Bosse
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Patent number: 4959500Abstract: Described are polybromoaromatic bis-sulfonamides containing at least two bromoaromatic groups, from 18 to 30 carbon atoms (preferably 18 to 24), and from 6 to 14 bromine atoms substituted on the aromatic rings. Such polybromoaromatic bis-sulfonamides may be represented by the general formula ##STR1## where Ar are the same or different polybromoaromatic groups, R is a divalent aromatic or bromoaromatic group, and R' and R" are independently hydrogen atoms, hydrocarbon groups or halohydrocarbon groups in which the halogen atoms are chlorine or bromine, the total number of bromine atoms substituted on the aromatic rings of the groups designated as Ar and R falling in the range of 6 to 14. These sulfonamides are useful as flame retardants and plasticizers for thermoplastic polymers and have the advantage of relatively low volatilities at polymer processing temperatures.Type: GrantFiled: May 23, 1989Date of Patent: September 25, 1990Assignee: Ethyl CorporationInventor: Robert A. Schleifstein
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Patent number: 4954513Abstract: This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists, pharmaceutical compositions containing such compounds, and methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.Type: GrantFiled: December 23, 1988Date of Patent: September 4, 1990Assignee: SmithKline Beecham CorporationInventors: John G. Gleason, Ralph F. Hall, Joanne Smallheer
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Patent number: 4939147Abstract: Compounds of the formula, ##STR1## in which one of R.sub.30 and R.sub.40 represents a substituted phenylalkyl group and the other of R.sub.30 and R.sub.40 represents hydrogen or halogen, and R.sub.50 and R.sub.60 each independently represent hydrogen or alkyl.The compounds of the invention are useful for the treatment or prophylaxis of renal failure or cardiovascular disease.Type: GrantFiled: August 2, 1989Date of Patent: July 3, 1990Assignee: Fisons plc.Inventors: John Dixon, Brian Springthorpe, Francis Ince
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Patent number: 4912258Abstract: Fluorinated aniline derivatives of the general formula I are described ##STR1## in which R.sup.1 represents H or (CH.sub.2).sub.n -X, n is a whole number from 1 to 3, X is H, OH, NH.sub.2, CH.sub.3 CONH, CH.sub.3 SO.sub.2 NH, SO.sub.3 H or ArSO.sub.3 H, Ar is optionally substituted arylene radical, R.sup.1 is alternatively also a --(CH.sub.2).sub.3 -- group, which is bonded to the free o-position next to the N-atom, Y is H, --O--, --NH--, --S-- or a C--C single bond, R.sup.2, in the event that Y=H, is the same as or different from R.sup.1 and means one of the radicals shown for R.sup.1, and in the event that Y is a C--C single bond or --O--, --NH-- or --S--, is an alkylene group having 1 to 3 carbon atoms linked with Y, and R.sup.3 =H, alkyl having 1 to 3 carbon atoms, OCH.sub.3, CH.sub.3 CONH, CO.sub.2 H or SO.sub.3 H.Type: GrantFiled: February 5, 1988Date of Patent: March 27, 1990Assignee: Boehringer Mannheim GmbHInventors: Hans-Georg Batz, Rupert Herrmann
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Patent number: 4888043Abstract: The invention concerns compounds of the formula I ##STR1## wherein: Z is selected from hydrogen, alkyl, alkanoyl, sulfamoyl, carboxy and trifluoroacetamido;Y is selected from various carboxy or thiocarboxy groups, haloalkanoyl, alkylsulfonyl and haloalkylsulfonyl;R.sup.1 is selected from hydrogen, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl and alkynyl;R.sup.3 is selected from alkyl; andR.sup.4 is selected from hydrogen, alkyl, and alkoxycarbonyl.The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments and the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.Type: GrantFiled: June 20, 1986Date of Patent: December 19, 1989Assignee: ICI Australia LimitedInventors: Keith G. Watson, Craig G. Lovel
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Patent number: 4877901Abstract: The present invention relates to a process for synthesizing N,N'-dithiobis(sulfonamides) by reacting a sulfonamide of the formula: ##STR1## with sulfur monochloride and caustic in a mixed organic-aqueous mediua, wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of alkyl radicals having from about 1 to about 20 carbon atoms, cycloalkyl radicals having from about 5 to about 20 carbon atoms, phenyl radicals, alkaryl radicals having from about 7 to 20 carbon atoms, and haloaryl radicals having about 6 to about 10 carbon atoms and where R.sup.1 is also selected from radicals having the formula: ##STR2## wherein R.sup.3 and R.sup.4 are individually selected from said alkyl, cycloalkyl, phenyl, alkaryl and haloaryl radicals and wherein R.sup.3 and R.sup.4 can be joined together to represent radicals selected from --CH.sub.2 --.sub.n, where n is an integer of 4 to 7 and --CH.sub.2).sub.2 O--CH.sub.2 --.sub.2.Type: GrantFiled: October 28, 1988Date of Patent: October 31, 1989Assignee: The Goodyear Tire & Rubber CompanyInventors: Roger J. Hopper, Niranjan V. Shah, Steven M. Ryba
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Patent number: 4874846Abstract: Process for the preparation of aryloxy-benzoic acids containing a sulphonamide group by the direct reaction of a phenoxy-benzoic acid with a sulphonamide, in the presence of a halogenating agent such as P(O)Cl.sub.3.Type: GrantFiled: May 26, 1987Date of Patent: October 17, 1989Assignee: Rhone-Poulenc Agrochimie S.A.Inventor: Alain Chene
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Patent number: 4837307Abstract: A 2,2'-bridged[1,1'-biphenyl]-3-ylmethyl compound of the following formula is an intermediate to insecticidal esters. ##STR1## wherein n is 1-4 and Y is a leaving group readily displaced by carboxylate anions.Type: GrantFiled: January 16, 1984Date of Patent: June 6, 1989Assignee: FMC CorporationInventor: Ernest L. Plummer
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Patent number: 4816576Abstract: The invention relates to a sulphonic acid amidamine corresponding to the following general formula I: ##STR1## wherein R.sup.1 represents a C.sub.8 -C.sub.30 linear, saturated aliphatic hydrocarbon group or said group which is substituted by one or more chlorine atoms;R.sup.2 and R.sup.5 independently represent hydrogen or C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkyl which is substituted with one of the groups: hydroxyl, amino, mercapto, cyano, carboxyl or carbamoyl, and/or is interrupted by at least one oxy (--O--) or thio (--S--) group;R.sup.3 and R.sup.4 independently represent C.sub.2 -C.sub.13 alkylene or C.sub.5 -C.sub.7 cycloalkylene or said alkylene or cycloalkylene groups which are substituted with one of the groups: hydroxyl, amino, mercapto, cyano, carboxyl or carbamoyl;p represents zero or an integer of from 1 to 3;q represents zero or an integer of from 1 to 12; andn represents an integer of from 1 to 8.Type: GrantFiled: June 23, 1986Date of Patent: March 28, 1989Assignee: Bayer AkteingesellschaftInventors: Hans-Josef Buysch, Wolfgang Wellner, Hermann Gruber
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Patent number: 4812512Abstract: Novel supports useful in solid phase synthesis of oligonucleotides of the formula ##STR1## wherein .circle.P is a material selected from the group consisting of functionalized glass micropellets, silica functionalized by aminoalkyl trialkoxysilane capable of to obtain for ##STR2## Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkyl of 1 to 20 carbon atoms, saturated cycloalkyl of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x and y are an integer from 0 to 20, x.sub.1 is an integer from 1 to 20 and y.sub.1 is an integer from 0 to 10, a process for the preparation of said supports, the use of said supports and intermediates.Type: GrantFiled: June 26, 1986Date of Patent: March 14, 1989Assignee: Roussel UclafInventors: Jean Buendia, Jeanine Nierat
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Patent number: 4780504Abstract: Novel supports useful in solid phase synthesis of oligonucleotides of the formula ##STR1## wherein .circle. is micro pellets of a material selected from the group consisting of glass, silica, Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkylene of 1 to 20 carbon atoms, saturated cycloalkylene of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x is an integer from 0 to 20, x.sub.1 is an integer from 0 to 10 and the amino group may be in the m-, p- or o-position, a process for the preparation of said supports, the use of said supports and intermediates.Type: GrantFiled: June 5, 1986Date of Patent: October 25, 1988Assignee: Roussel UclafInventors: Jean Buendia, Jeanine Nierat
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Patent number: 4767446Abstract: A herbicidal composition which comprises as an active ingredient a trifluoromethanesulfonanilide of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, same or different, each a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.4 alkyl group and R.sub.3 and R.sub.4 are, same or different, each a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group, a C.sub.3 -C.sub.4 alkenyl group, a C.sub.3 -C.sub.5 alkynyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.6 -C.sub.7 aralkyl group, a C.sub.1 -C.sub.4 alkoxy(C.sub.1 -C.sub.4)alkyl group or a C.sub.2 -C.sub.4 acyl group or they may be combined together with the nitrogen atom to form a morpholino group, and X is a hydrogen atom or a C.sub.2 -C.sub.4 acyl group, provided that R.sub.3 and R.sub.4 are not simultaneously hydrogen.Type: GrantFiled: March 25, 1985Date of Patent: August 30, 1988Assignee: Sumitomo Chemical Company, LimitedInventors: Hiroyuki Konishi, Shunichi Hashimoto, Hiromichi Oshio
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Patent number: 4721809Abstract: This invention provides Class III anti-arrhythmic agents of the formula: ##STR1## in which R.sup.1 is alkylsulfonamido, arylsulfonamido, perfluoroalkylsulfonamido, R.sup.2 and R.sup.3 are hydrogen or alkyl, R.sup.4 is alkyl, and n is 2 to 4, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 18, 1986Date of Patent: January 26, 1988Assignee: American Home Products CorporationInventors: George C. Buzby, Jr., Thomas J. Colatsky
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Patent number: 4697011Abstract: N-fluoro-N-perfluoromethyl sulfonamide compounds are provided as fluorinating agents for the fluorination of organic compounds by either the direct electrophilic fluorination of organic compounds or by the fluorination of organic compound carbanions.Type: GrantFiled: July 18, 1986Date of Patent: September 29, 1987Assignee: Research CorporationInventor: Darryl D. DesMarteau
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Patent number: 4668792Abstract: Substituted [1,1'-biphenyl]-3-ylmethyl compounds carrying leaving groups are intermediates to insecticidal esters.Type: GrantFiled: December 20, 1983Date of Patent: May 26, 1987Assignee: FMC CorporationInventor: Ernest L. Plummer
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Patent number: 4664834Abstract: A composition is disclosed which comprises a water-dispersible reaction product of (A) at least one compound represented by the formula ##STR1## wherein R is a hydrocarbyl group of from about 8 to about 40 carbon atoms, with (B) at least one water-dispersible amine terminated poly(oxyalkylene). Aqueous concentrates and water-based functional fluids comprising these compositions are also disclosed. These reaction products are useful as shear-stable thickeners for such functional fluids.Type: GrantFiled: July 29, 1985Date of Patent: May 12, 1987Assignee: The Lubrizol CorporationInventor: John W. Forsberg
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Patent number: 4652303Abstract: The invention concerns novel compounds of the formula I ##STR1## wherein: W are selected from the group consisting of:the groups R.sup.5 --CO-- and R.sup.5 --CS-- wherein: R.sup.5 is selected from alkenyl, alkynyl, benzyl, phenyl, substituted alkyl, substituted alkenyl, substituted alkynyl, substituted benzyl, substituted phenyl and the acetal, hemiacetal, oxime, imine and Schiff base derivatives of the group R.sup.5 --CO--;the groups Y--CO-- and Y--CS-- wherein Y is selected from hydroxy, mercapto, alkylthio and the groups MO-- and MS-- wherein M is an organic or an inorganic cation;the groups R.sup.6 R.sup.7 NCO-- and R.sup.6 R.sup.7 NCS-- wherein R.sup.6 and R.sup.7 are independently selected from hydrogen, alkyl, substituted alkyl, alkanoyl, carboxy, alkoxycarbonyl, alkylsulfonyl, benzoyl, benzenesulfonyl, substituted benzoyl, substituted benzenesulfonyl, or R.sup.6 and R.sup.Type: GrantFiled: July 2, 1984Date of Patent: March 24, 1987Assignee: ICI Australia LimitedInventors: Keith G. Watson, Graham J. Bird, Graeme J. Farquharson