Plural Sulfonamide Groups Containing Or Containing Plural Sulfonyls Bonded Directly To The Same Nitrogen Patents (Class 564/82)
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Patent number: 4634705Abstract: Disclosed herein are adrenergic compounds represented by the formula ##STR1## wherein m is 0, 1 or 2; R.sub.1, R.sub.2, R.sub.3 and R.sub.7 are taken from the group consisting of hydrogen, hydroxy, loweralkyl, loweralkoxy, halo, amino, acetamido or NHSO.sub.2 R wherein R is taken from the group consisting of hydrogen or loweralkyl, provided that R.sub.1, R.sub.2, R.sub.3 and R.sub.7 cannot simultaneously be hydrogen or halo, and provided that when one of R.sub.1, R.sub.2, R.sub.3 and R.sub.7 is halo, the others cannot simultaneously be hydrogen and when two of R.sub.1, R.sub.2, R.sub.3 and R.sub.7 are halo, the other two cannot simultaneously be hydrogen and provided that R.sub.1 and R.sub.7 cannot simultaneously be methoxy each when R.sub.2 and R.sub.3 are hydrogen; R.sub.1 and R.sub.2 or R.sub.2 and R.sub.3 or R.sub.3 and R.sub.7 taken together can form a methylenedioxy or ethylenedioxy bridge; or R.sub.1 and R.sub.2 or R.sub.2 and R.sub.3 or R.sub.3 and R.sub.Type: GrantFiled: March 7, 1986Date of Patent: January 6, 1987Assignee: Abbott LaboratoriesInventors: John F. DeBernardis, Fatima Z. Basha
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Patent number: 4602097Abstract: Photoinitiators of the formulaG--O--(CH.sub.2 CH.sub.2 O).sub.n --CH.sub.2 --CH.sub.2 --O--Qwherein G is a photoinitiator moiety, R is hydrogen or lower alkyl, n has a value of at least 10, and Q is G or a lower alkyl are soluble in water and common organic solvents and are useful in polymerization systems employed in coatings used in screen printing.Type: GrantFiled: June 11, 1984Date of Patent: July 22, 1986Assignee: Ulano CorporationInventor: John R. Curtis
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Patent number: 4582905Abstract: Convenient intermediates for preparing 3-substituted-2-hydroxypropyl aryl ether .beta.-blockers, a reaction to the intermediates of the following formula and a conversion to obtain the said .beta.-blockers are disclosed. ##STR1## (wherein X is hydrogen or halogen; Y is halogen, hydroxy, lower acyloxy, amino, lower alkylamino, lower aralkylamino, lower acylamino, di-lower alkylamino, lower alkyleneamino, N-lower alkyl-N-lower aralkylamino, di-lower acylamino, N-lower alkyl-N-lower acylamino or N-tri-lower alkylsilylamino;one of P and R combined together with Q represents lower alkylene or alkenylene optionally interrupted by O, N or S and optionally substituted by lower alkyl, lower aralkyl, lower carboxylic acyl, carboxy, protected carboxy; hydroxy, lower alkoxy, lower acyloxy, oxo; amino, lower alkylamino, lower acylamino, nitro, nitroso, lower alkylthio, lower sulfonic acyl or halogen;and the remaining R or P is hydrogen or halogen;and dotted line represents the presence of one or two double bonds).Type: GrantFiled: December 20, 1984Date of Patent: April 15, 1986Assignee: Shionogi & Co., Ltd.Inventor: Makiko Sakai
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Patent number: 4567004Abstract: Monomethyl-substituted methylene compounds are obtained by reacting methylene compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 independently of one another represent --CN, --CO--R.sup.3, --SO.sub.2 --R.sup.3 or --NO.sub.2 andR.sup.1 can additionally denote -aryl(R.sup.1).sub.n,whereinR.sup.3 denotes --OH, alkyl, aralkyl, aryl, alkoxy, aralkoxy or aryloxy, or amino which is substituted by alkyl and/or aralkyl and/or aryl, and furthermoretwo radicals R.sup.3 together can be an alkylene group, the radical of an aliphatic diol or of an aliphatic diamine or the group --NH--CO--NH-- and n represents 1, 2 or 3,with formaldehyde and with hydrogen in the presence of a condensation catalyst and a hydrogenation catalyst at elevated temperature, the methylene compound being introduced into the liquid phase of the mixture of reactants in the course of the reaction.Type: GrantFiled: July 18, 1984Date of Patent: January 28, 1986Assignee: Bayer AktiengesellschaftInventors: Heinz U. Blank, Erich Wolters
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Patent number: 4564386Abstract: A herbicidal composition which comprises as an active ingredient a trifluoromethanesulfonanilide of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, the same or different, each a hydrogen atom, a halogen atom or a C.sub.1 -C.sub.4 alkyl group, R.sub.3 and R.sub.4 are, the same or different, each a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group, a C.sub.3 -C.sub.4 alkenyl group, a C.sub.3 -C.sub.5 alkynyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.6 -C.sub.7 aralkyl group, a C.sub.1 -C.sub.4 alkoxy(C.sub.1 -C.sub.4)alkyl group or a C.sub.2 -C.sub.5 acyl group or they may be combined together with the nitrogen atom to form a morpholino group and X is a C.sub.2 -C.sub.5 acyl group, provided that R.sub.3 and R.sub.4 are not simultaneously a hydrogen atom or a C.sub.2 -C.sub.5 acyl group.Type: GrantFiled: August 4, 1983Date of Patent: January 14, 1986Assignee: Sumitomo Chemical Company, LimitedInventors: Hiroyuki Konishi, Shunichi Hashimoto, Hiromichi Oshio
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Patent number: 4549015Abstract: New hydroquinone ether compounds of formula I are described: ##STR1## wherein p is 1 or 2 and q is 0 or 1, provided that p+q is 1 or 2, R is a residue of formula II ##STR2## and R.sub.o, R.sub.oo, R.sub.1, R.sub.2, R.sub.3, Q, n and k are as defined in the specification.The new compounds are useful e.g. as stabilizers in photographic material.Type: GrantFiled: June 14, 1983Date of Patent: October 22, 1985Assignee: Ciba-Geigy AGInventor: Frederick H. Howell
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Patent number: 4545995Abstract: The novel unsaturated arylalkyl ammonium salts described herein are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided, as well as pharmaceutical formulations containing such ammonium salts.Type: GrantFiled: July 12, 1983Date of Patent: October 8, 1985Assignee: Schering A.G.Inventors: William C. Lumma, Jr., Ronald A. Wohl
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Patent number: 4533713Abstract: Compounds containing (a) a fluoroaliphaticsulfonamido moiety, and (b) a moiety containing (1) at least two oxirane groups, (2) at least two non-terminal N-.beta.-hydroxyalkylene groups, or (3) at least one oxirane group and at least one non-terminal N-.beta.-hydroxyalkylene group. The compound is capable of being cured with a curing agent to give a cured product having excellent water resistance and oil resistance.Type: GrantFiled: May 6, 1983Date of Patent: August 6, 1985Assignee: Minnesota Mining and Manufacturing CompanyInventor: Richard D. Howells
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Patent number: 4510324Abstract: The invention provides disulfonimide compounds of the general formula ##STR1## wherein X is bromine, chlorine or iodine; R is hydrogen or methyl; and R' is alkyl, aryl or substituted aryl. The compounds are useful as activators for anaerobic adhesive compositions and also as intermediates in the preparation of monomers of the general formula ##STR2## wherein R and R' are as defined above. The monomers are polymerizable to form homo- and copolymers useful in the photographic industry as well as in formulating anaerobic adhesive compositions.Type: GrantFiled: April 28, 1983Date of Patent: April 9, 1985Assignee: National Starch and Chemical Corp.Inventors: Robert D. Rossi, Dilip K. Ray-Chaudhuri
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Patent number: 4505997Abstract: The invention relates to novel ionic compounds which can be incorporated in polymers whose monomer units include at least one hetroatom, particularly oxygen or nitrogen adapted to form bonds of the donor-acceptor type with the cation of the ionic compound, the solid solutions obtained being utilizable to form the electrolyte of an electrochemical generator. These ionic compounds are represented by the formula(C.sub.n X.sub.2n+1 Y).sub.2 N.sup.-,M.sup.+in which : X is a halogen, n varies from 1 to 4, Y is a CO or SO.sub.2 group and M is an alkali metal.Type: GrantFiled: June 1, 1983Date of Patent: March 19, 1985Assignees: Agence Nationale de Valorisation de la Recherche (ANVAR), Societe Nationale Elf AquitaineInventors: Michel B. Armand, Fouzia El Kadiri Cherkaoui el Moursli
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Patent number: 4504492Abstract: Compounds of the general formula ##STR1## wherein Ph is a phenyl group which is optionally substituted by one or more substituents selected from halo (i.e. fluoro, chloro, bromo or iodo), C.sub.1-4 alkyl, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, nitro, sulphonyl, aminosulphonyl, trihalomethyl, carboxy, C.sub.1-4 alkoxycarbonyl, amido, C.sub.1-4 alkylamido, C.sub.1-4 alkoxy, C.sub.2-4 alkenyl, cyano, aminomethyl, or methylsulphonyl; Y is a group of formula ##STR2## where R.sup.1 is hydrogen or methyl; R.sup.2 is alkyl of 1 to 3 carbon atoms or is methylthiomethyl; and Z is --OR.sup.3 or --NR.sup.4 R.sup.5 where R.sup.3, R.sup.4 and R.sup.5 are each hydrogen or alkyl of 1 to 4 carbon atoms and R.sup.3 can further be phenylalkyl having 1 to 3 carbon atoms in the alkylene moiety thereof, or phenyl; and basic salts thereof. These compounds have an advantageous enkephalinase inhibitory activity which renders the compounds useful in medical therapy, e.g.Type: GrantFiled: September 24, 1982Date of Patent: March 12, 1985Assignee: Burroughs Wellcome Co.Inventors: Samuel Wilkinson, George W. Hardy
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Patent number: 4499105Abstract: The present invention is dealing with compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, in which n and m represent the number 1 or 2, X and Y hydrogen, alkyl (1-4 C), alkoxy (1-4 C), hydroxy, halogen, hydroxymethyl, trifluoromethyl, acyl (1-4 C), acyloxy (1-4 C) or the group NR.sub.x R.sub.y, in which R.sub.x and R.sub.y represent hydrogen, alkyl (1-4 C) or a sulphonyl group and R represents the group ##STR2## in which R.sub.1 and R.sub.2 represent hydrogen, alkyl (1-4 C), hydroxy, alkoxy (1-4 C), phenylalkoxy (7-10 C), acyloxy, amino or mono or dialkyl (1-4 C) amino, having potent platelet aggregation inhibiting properties.Type: GrantFiled: December 28, 1982Date of Patent: February 12, 1985Assignee: Akzo N.V.Inventor: Harm J. Panneman
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Patent number: 4499304Abstract: Color-forming para-sulfonamidodiphenylamines and their corresponding sulfonimide dyes are useful in imaging materials. The color-forming sulfonamidodiphenylamines are prepared by condensation reactions. The corresponding sulfonimide dyes are formed by oxidation of the color-forming sulfonamidodiphenylamines by means of a suitable oxidizing agent, such as the oxidized form of a cross-oxidizing silver halide developing agent.Type: GrantFiled: June 8, 1982Date of Patent: February 12, 1985Assignee: Eastman Kodak CompanyInventors: Rolf S. Gabrielsen, Patricia A. Graham, James E. Klijanowicz, Max H. Stern
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Patent number: 4477680Abstract: A method for increasing the growth rate and/or improving the lean meat to fat ratio in farm and domestic animals. An effective amount of a 3-amino-4-hydroxy(or alkoxy)phenethanolamine derivative, pharmacologically-acceptable acid addition or metal salt thereof is administered either orally or parenterally to animals. Novel 3-amino-4-hydroxy(or alkoxy)phenethanolamine derivatives are also described.Type: GrantFiled: November 5, 1982Date of Patent: October 16, 1984Assignee: American Cyanamid CompanyInventor: Goro Asato
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Patent number: 4474806Abstract: Sulfonyl or carbonyl derivatives of inositols are found to be effective phospholipase C inhibitors and thereby potent anti-inflammatory and analgesic agents. These inositol derivatives are prepared by condensation of a protected inositol with a substituted sulfonic or carboxylic acid derivative followed by removal of protecting groups.Type: GrantFiled: May 10, 1982Date of Patent: October 2, 1984Assignee: Merck & Co., Inc.Inventors: Thomas R. Beattie, Shu S. Yang
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Patent number: 4438133Abstract: Novel cystine derivatives having the structural formula (I): ##STR1## wherein R is benzyloxycarbonyl or tosyl, and the pharmaceutically acceptable acid addition salts thereof, are effective expectorants and antitussives, and are also effective for the liquescence of respiratory tract fluids.Type: GrantFiled: June 28, 1982Date of Patent: March 20, 1984Assignee: Recordati S.A.Inventors: Dante Nardi, Alberto Tajana, Gianni Motta, Pietro Cazzulani, Gabriele Graziani
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Patent number: 4435394Abstract: 3-Sulfonamido-benzophenonimine derivatives useful for prophylactically or therapeutically treating patients suffering from viral infections are provided from 3-sulfonamido-benzophenones.Type: GrantFiled: December 17, 1981Date of Patent: March 6, 1984Assignee: Shionogi & Co., Ltd.Inventors: Masaru Ogata, Kosaburo Sato
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Patent number: 4407743Abstract: N,N'-bis(trifluoromethylsulfonyl)oxamides are described with 2,2,2-trifluoroethyl, (ethoxycarbonyl)methyl, and [(phenylmethoxy)carbonyl]methyl substitution at the amido nitrogen atoms. These compounds, when used in chemiluminescent formulations, furnish superior light capacity and quantum efficiency. Preparation of the compounds and their use for chemiluminescence are described.Type: GrantFiled: March 19, 1982Date of Patent: October 4, 1983Assignee: American Cyanamid CompanyInventor: Shin-Shyong Tseng
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Patent number: 4385047Abstract: Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and bis-(chlorosulfonyl)imide in the presence of a non-nucleophilic organic base. Pharmaceutical compositions and methods of alleviating the symptoms of an allergic response are also disclosed.Type: GrantFiled: January 5, 1981Date of Patent: May 24, 1983Assignee: SmithKline Beckman CorporationInventor: Fadia E. Ali
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Patent number: 4380666Abstract: A color-forming para sulfonamidodiphenylamine dye precursor has one or two sulfonamido groups in positions ortho to the amine --NH-- moiety separating the two phenyl rings of the para sulfonamidodiphenylamine and, in oxidized form, intramolecularly reacts to produce a sulfonamido-substituted phenazine dye. Such color-forming para sulfonamidodiphenylamine dye precursors are useful to produce a dye image by cross-oxidation in an imaging material.Type: GrantFiled: July 6, 1981Date of Patent: April 19, 1983Assignee: Eastman Kodak CompanyInventors: Rolf S. Gabrielsen, Patricia A. Graham, James E. Klijanowicz
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Patent number: 4375479Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methanesulfonyl, or acetyl,R.sub.2 and R.sub.3 jointly mean oxo, oximino, or separately two hydrogen atoms, orR.sub.2 is hydrogen and R.sub.3 is hydroxy or amino, and when R.sub.3 is amino, the physiologically acceptable acid salts thereofpossess valuable pharmacological properties.Type: GrantFiled: January 27, 1982Date of Patent: March 1, 1983Assignee: Schering AktiengesellschaftInventors: Eberhard Schroeder, deceased, Clemens Rufer
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Patent number: 4373017Abstract: A photosensitive material having a photosensitive layer provided on a support which photosensitive layer comprises a photosensitive compound which forms a color dye directly under irradiation of ultraviolet rays, the compound being represented by the formula [i]: ##STR1## wherein [COUP] represent a 4-equivalent yellow, magenta or cyan coupler from which a hydrogen is removed at a coupling position thereof, B is a hydroxy group or ##STR2## wherein R.sup.6 and R.sup.7 are individually an alkyl group or they may form a 1-piperidino, 1-piperazino, 1-pyrolidino or 4-morpholino group together with each other,R.sup.1 is an alkyl, aryl, alkylamino or arylamino group, and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 individually are a hydrogen or halogen atom or aliphatic or aromatic group, or R.sup.2 and R.sup.3 may be fused to form a naphthalene ring.Type: GrantFiled: March 5, 1981Date of Patent: February 8, 1983Assignee: Konishiroku Photo Industry Co., Ltd.Inventors: Toyoaki Masukawa, Wataru Ishikawa, Kenichiro Okaniwa, Kiyoshi Yamashita
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Patent number: 4353834Abstract: Biodegradable non-ionic surface-active agents containing carbonate groups can be prepared by reacting hydrophilic polyoxyalkylene glycols derived from the same or different alkylene oxides with hydrophobic amides or sulfonamides. The compositions of the invention contain both hydrophilic and hydrophobic groups in the molecule making them suitable for use as surface-active agents.Type: GrantFiled: March 13, 1981Date of Patent: October 12, 1982Assignee: BASF Wyandotte CorporationInventor: William K. Langdon
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Patent number: 4327113Abstract: Novel 1-heterocyclyloxy- or 1-aryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity. Representative of the compounds disclosed is 1-(4-indolyloxy)-3-.beta.-isobutyramidoethylamino-2-propanol.Type: GrantFiled: December 12, 1980Date of Patent: April 27, 1982Assignee: Imperial Chemical Industries LimitedInventor: Leslie H. Smith
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Patent number: 4317819Abstract: The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.Type: GrantFiled: December 5, 1980Date of Patent: March 2, 1982Assignee: Glaxo Group LimitedInventors: John W. Clitherow, Barry J. Price, John Bradshaw, Michael Martin-Smith
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Patent number: 4314820Abstract: The distyrylbenzenes of the formula ##STR1## in which X and X' independently of one another are --COO-- or --CON(R.sub.4)-- in the o-position, a direct bond, oxygen, sulfur, --O--C.sub.1-3 --alkylene--CON(R.sub.4)--, --SO.sub.2 N(R.sub.4)--, --O--C.sub.1-3 -alkylene--COO-- or --OCO--, Y and Y' independently of one another are C.sub.1-20 -alkylene, R.sub.1 and R.sub.1 ' independently of one another are unsubstituted or substituted C.sub.1-8 -alkyl or C.sub.3-4 -alkenyl, or R.sub.1 together with R.sub.2, or R.sub.1 ' together with R.sub.2 ', is a heterocyclic ring, R.sub.2 and R.sub.2 ' independently of one another are unsubstituted or substituted C.sub.1-8 -alkyl or C.sub.3-4 -alkenyl, or R.sub.2 together with R.sub.1, or R.sub.2 ' together with R.sub.1 ', is a heterocyclic ring, or R.sub.1 and R.sub.2, or R.sub.1 ' and R.sub.2 ', together with R.sub.3 are a pyridine or picoline ring, R.sub.3 is hydrogen, unsubstituted or substituted C.sub.1-4 -alkyl or C.sub.3-4 -alkenyl, or together with R.sub.1 and R.sub.Type: GrantFiled: April 2, 1980Date of Patent: February 9, 1982Assignee: Ciba-Geigy CorporationInventors: Kurt Weber, Hans R. Meyer
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Patent number: 4314055Abstract: Certain 3,5-disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids are useful as x-ray contrast agents. Representative of this class of compounds is the compound 3-gluconamido-2,4,6-triiodo-N-methyl-5-(N-methyl-acetamido)-benzamide and the compound 3-gluconamido-5-[N-(2-hydroxyethyl)acetamido]-2,4,6-triiodo-N-methylbenzam ide.Type: GrantFiled: March 29, 1977Date of Patent: February 2, 1982Assignee: Mallinckrodt, Inc.Inventors: George B. Hoey, George P. Murphy, Philip E. Wiegert, James W. Woods
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Patent number: 4252813Abstract: Compounds of the formula ##STR1## are useful as anti-allergy agents.Type: GrantFiled: November 19, 1979Date of Patent: February 24, 1981Assignee: The Upjohn CompanyInventor: John B. Wright
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Patent number: 4243584Abstract: Monoazo dyestuffs of the formula ##STR1## wherein R.sub.1 represents an aromatic radical, an aliphatic radical with 1-4 C atoms or a dialkylamino radical, in which the alkyl groups contain 1-C atoms, R.sub.2 represents hydrogen, halogen, alkyl with 1-C atoms, alkoxy with 1-4 C atoms or trifluoromethyl, R.sub.3 represents hydrogen, halogen, alkyl with 1-4 C atoms, alkoxy with 1-4 C atoms or trifluoromethyl and K represents the radical of a coupling component K-H of the formulae (II), (III) and (IV) ##STR2## wherein R.sub.4 represents alkyl with 1-4 C atoms or aryl,R.sub.5 represents hydrogen or unsubstituted alkyl with 1-4 C atoms,R.sub.6 represents hydrogen, nitrile, halogen, alkyl with 1-4 C atoms or alkoxy with 1-4 C atoms,R.sub.7 represents hydrogen, alkyl with 1-4 C atoms, aryl, a carboxylic acid ester group or a carboxylic acid amide group,R.sub.8 represents hydrogen, alkyl, cycloalkyl, aryl or the radical of a heterocyclic compound,R.sub.Type: GrantFiled: June 27, 1978Date of Patent: January 6, 1981Assignee: Bayer AktiengesellschaftInventors: Richard Sommer, Gerhard Wolfrum, Gerhard Buttner