Preparing By Reacting A Thiol Or Mercaptide (i.e., Reactant Contains -sh Or -sm Where M Is A Group Ia Or Iia Light Metal) Patents (Class 568/26)
  • Patent number: 10093619
    Abstract: A method of producing an organopolysulfide or salt thereof is provided which includes a step of mixing an organomonosulfide or salt thereof and elemental sulfur, wherein the mixing is carried out at a temperature not greater than 95 C and in the absence of any added liquid phase for a time effective to produce the organopolysulfide or salt thereof. The described method makes possible the preparation of organopolysulfides and organopolysulfide salts without the use of solvent or catalyst.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: October 9, 2018
    Assignee: Arkema Inc.
    Inventors: George C. Fortman, Gary S. Smith
  • Patent number: 8987519
    Abstract: The present disclosure relates to a process for obtaining dialkyl disulphides from alkyl mercaptan and from sulphur, in which a reaction intermediate present in the final disulphide is decomposed at the end of synthesis. This operation makes it possible to avoid the degradation of said reaction intermediate over time, which is responsible for the decrease in purity of the dialkyl disulphide.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: March 24, 2015
    Assignee: Arkema France
    Inventors: Georges Fremy, Jean-Michel Raymond
  • Publication number: 20140235897
    Abstract: One exemplary embodiment can be a process for oxidizing one or more thiol compounds from an alkaline stream. The process may include passing a mixed stream having the alkaline stream to an oxidation vessel having a body and a neck. Often, the body contains one or more packing elements and the neck contains a packing, a distributor, and a mesh. The process can further include passing an oxidized alkaline stream to a separation vessel containing a first chamber and a second chamber. Usually, the first chamber contains a coated mesh.
    Type: Application
    Filed: February 19, 2013
    Publication date: August 21, 2014
    Applicant: UOP, LLC
    Inventors: Jonathan Andrew Tertel, Jasna Karagic, Jessy E. Trucko
  • Patent number: 8741960
    Abstract: The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein Y, L, A, W1, W2, and R?1 are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: June 3, 2014
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Shoujun Chen, Lijun Sun, Yu Xie
  • Publication number: 20130267739
    Abstract: The present disclosure relates to a process for obtaining dialkyl disulphides from alkyl mercaptan and from sulphur, in which a reaction intermediate present in the final disulphide is decomposed at the end of synthesis. This operation makes it possible to avoid the degradation of said reaction intermediate over time, which is responsible for the decrease in purity of the dialkyl disulphide.
    Type: Application
    Filed: September 30, 2011
    Publication date: October 10, 2013
    Applicant: Arkema France
    Inventors: Georges Fremy, Jean-Michel Raymond
  • Patent number: 8470197
    Abstract: A crosslinked polysulfide-containing cycloaliphatic compound, useful as a crosslinker for filled sulfur-vulcanizable elastomer compositions, is represented by the general formula: [(CaH2a-)mG1(-CbH2bSx—)n?m]o[CcH2c-G2-CdH2dSy—]p[R]q wherein G1 is a saturated, monocyclic aliphatic group of valence n containing from 5 to 12 carbon atoms and optionally containing at least one halogen or a saturated monocyclic silicone [RSiO—]n[R2SiO—]r group of valence n; G2 is a saturated, divalent cyclic aliphatic group of valence 2 containing from 5 to 12 carbon atoms and optionally containing at least one halogen or a saturated monocyclic silicone [RSiO—]n[R2SiO—]r group of valence n; each R independently is a selected from the group consisting of a hydrogen atom, monovalent hydrocarbon of up to 20 carbon atoms and a halogen atom; each occurrence of subscripts a, b, c, d, m, n, o, p, q, x and y independently is an integer wherein a is 2 to 6; b is 2 to 6; c is 1 to 6; d is 1 to 6; m is 1 or 2; n is 3 to 5; o is a positive
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: June 25, 2013
    Assignee: Momentive Performance Materials Inc.
    Inventors: Richard W. Cruse, William Michael York, Carla Recker, Thomas Kramer, Katharina Herzog
  • Publication number: 20130123514
    Abstract: The disclosure relates to catalytically active carbocatalysts, e.g., a graphene oxide or graphite oxide catalyst suitable for use in a variety of chemical transformations. In one embodiment, it relates to a method of catalyzing a chemical reaction of an organic molecule by reacting the organic molecule in the presence of a sufficient amount of graphene oxide or graphite oxide for a time and at a temperature sufficient to allow catalysis of a chemical reaction. According to other embodiments, the reaction may be an oxidation reaction, a hydration reaction, a dehydrogenation reaction, a condensation reaction, or a polymerization reaction. Some reactions may include auto-tandem reactions. The disclosure further provides reaction mixtures containing an organic molecule and graphene oxide or graphite oxide in an amount sufficient to catalyze a reaction of the organic molecule.
    Type: Application
    Filed: May 27, 2011
    Publication date: May 16, 2013
    Applicant: GRAPHEA, INC.
    Inventors: Christopher W. Bielawski, Daniel R. Dreyer, Hong-Peng Jia
  • Patent number: 8334340
    Abstract: A sulfur-containing cycloaliphatic compound, useful as a crosslinker for filled sulfur-vulcanizable elastomer compositions, is represented by the general formula: G[—CaH2a—S—S(?O)b—R]n wherein G is a saturated, monocyclic aliphatic group of valence n containing from 5 to 12 carbon atoms and optionally containing at least one halogen or a saturated monocyclic silicone [RSiO—]n[R2SiO—]p group of valence n; each R independently is a monovalent hydrocarbon of up to 20 carbon atoms; each occurrence of subscripts a and b independently is an integer wherein a is 2 to 6 and b is 1 or 2; n is an integer of from 3 to 6; and p is an integer of from 0 to 3.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: December 18, 2012
    Assignee: Momentive Performance Materials, Inc.
    Inventors: Michael Joseph O'Brien, Robert James Perry, Richard W. Cruse, William Michael York, Carla Recker, Thomas Kramer, Katharina Herzog
  • Publication number: 20120283430
    Abstract: Organo-metallic materials with reduced steric hindrance and the ability to aggregate ar disclosed. The metal remains capable of binding additional molecules. As an example, Zn complexes that prove aggregation are provided. Such aggregation may help improve or trigger new surface properties of the materials, alone or in combination with others. In a further implementation of the present disclosure, a robust molecule that resists degradation via nucleophilic, electrophilic and radical attacks is provided. Coordinated O2 is reduced catalytically, producing efficiently thyil radicals in spite of the extreme electronic deficiency of the catalyst.
    Type: Application
    Filed: November 1, 2011
    Publication date: November 8, 2012
    Applicant: NEW JERSEY INSTITUTE OF TECHNOLOGY
    Inventors: Sergiu M. Gorun, Andrei Ioan Loas, Kimberly Griswold, Lukasz Lapok, Hemantbhai Hasmukhbhai Patel, Robert Gerdes
  • Publication number: 20110263894
    Abstract: A process for compressing a hydrogen-sulfide-comprising gas stream, which comprises (i) compressing the hydrogen-sulfide-comprising gas stream in a compressor, (ii) flushing the compressor with a mixture comprising dialkyl polysulfides, dialkyl disulfides and at least one amine; a process for producing sulfur compounds, selected from the group consisting of alkylmercaptans, dialkyl disulfides and alkanesulfonic acids, which comprises the conversion of hydrogen-sulfide-comprising gas streams, wherein the hydrogen-sulfide-comprising gas streams are compressed according to the process comprising steps i) and ii); and also the use of a mixture comprising dialkyl polysulfides, dialkyl disulfides and at least one amine for removing sulfur deposits which occur in the compression of hydrogen-sulfide-comprising gas streams.
    Type: Application
    Filed: December 22, 2009
    Publication date: October 27, 2011
    Applicant: BASF SE
    Inventors: Andreas Woelfert, Frank Grzonkowski, Harald Jachow, Guenter Renz
  • Publication number: 20110172138
    Abstract: One subject of the invention is a dimethyl disulphide in which the content of biocarbon is at least 1%. Another subject of the invention is processes for preparing this dimethyl disulphide. Yet another subject of the invention is the use of such a dimethyl disulphide for the manufacture of methanesulphonic acid.
    Type: Application
    Filed: August 18, 2009
    Publication date: July 14, 2011
    Applicant: ARKEMA FRANCE
    Inventors: Christian Forquy, Georges Fremy
  • Patent number: 7947757
    Abstract: The invention relates to an initiator comprising at least one structural element characterized by the following formula (I) wherein X? is a non or low coordinating anion, R1, R2, R3, R4 are independently linear, cyclic or branched C1-C20 alkyl or alkylene groups, wherein one or more of the methylene groups contained in the alkyl or alkylene group can be substituted by —CO—, —CONH—, —CON(CH3)—, —S— and/or —O—, and wherein R1, R2, R3 and/or R4 can act as a bridging element connecting two or more structural elements. The invention is also related to a process of producing the initiator and to a curable composition comprising the initiator, a process for producing the curable composition a kit comprising a cationically curable composition and the inventive initiator and the use of the initiator or the curable composition comprising the initiator for various applications, especially in the dental field.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: May 24, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: Thomas Klettke, Cornelia B. Fuehrer, Andrea Hailand, Markus Mikulla
  • Patent number: 7906683
    Abstract: The mercaptans R—SH contained in a hydrocarbon stream are oxidized to the corresponding (di)sulfides by means of a redox system which comprises trivalent iron and a heteropolyacid which allows the complete reoxidation of the reduced iron also with air.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: March 15, 2011
    Assignee: ENI S.p.A.
    Inventors: Alberto De Angelis, Paolo Pollesel
  • Publication number: 20100222549
    Abstract: A dechalcogenative method for the preparation of an allylic sulfide comprises contacting an activated chalcogenide of Formula (I) with a thiol of Formula (II) for a period of time sufficient to form an intermediate of Formula (III), and supplying sufficient activation energy to the intermediate of Formula (III), in a suitable solvent, preferably in the absence of a phosphine or other thiophile, to induce a [2,3]-sigmatropic rearrangement therein to form an allylic sulfide of Formula (IV), with concomitant loss of chalcogen Z, as set forth in the following reaction scheme, wherein X is an activating group selected from the group consisting of CN, S-pyridyl, S-heteroaryl, SO2-aryl, and SO3Y; Y is an alkali metal ion; Z is Se or S; R1, R2, R3, R4, and R5 are each independently H or a hydrocarbon moiety; and R is an organic moiety.
    Type: Application
    Filed: April 29, 2008
    Publication date: September 2, 2010
    Inventors: David Crich, Maheswaran Karatholuvhu, Venkataramanan Krishnamurthy, Thomas K. Hutton, Franck Brebion, Venkataraman Subramanian
  • Patent number: 7674444
    Abstract: A sulfur species-containing feed gas is processed in a treatment plant in which COS is hydrolyzed, and in which so produced hydrogen sulfide and other sulfur species are absorbed in a lean hydrocarbon liquid. The sulfur species in the so formed rich hydrocarbon liquid are then subjected to catalytic conversion into disulfides, which are subsequently removed from the rich solvent. Most preferably, sulfur free lean solvent is regenerated in a distillation column and/or refinery unit, and light components are recycled from the rich hydrocarbon liquid to the absorber.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: March 9, 2010
    Assignee: Fluor Technologies Corporation
    Inventor: John Mak
  • Publication number: 20080207951
    Abstract: The mercaptans R—SH contained in a hydrocarbon stream are oxidized to the corresponding (di)sulfides by means of a redox system which comprises trivalent iron and a heteropolyacid which allows the complete reoxidation of the reduced iron also with air.
    Type: Application
    Filed: February 15, 2006
    Publication date: August 28, 2008
    Applicant: ENI S.P.A.
    Inventors: Alberto De Angelis, Paolo Pollesel
  • Patent number: 7381847
    Abstract: A process is disclosed for the production of olefins including ethylene, propylene and butenes from methyl mercaptan. The process comprises a reaction whereby methyl mercaptan decomposes to produce the olefin and hydrogen sulfide. The reaction is carried out at an elevated temperature in the range of 300° C. to 500° C. to achieve pyrolysis. Alternatively, a heterogeneous catalyst may be used.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: June 3, 2008
    Inventor: John E. Stauffer
  • Patent number: 7332145
    Abstract: Disclosed is a process for the treatment of gas containing mercaptans and acid gases, including the following steps: (1) separating the acid gases from the said gas and obtaining a sweetened gas and the flow of acid gases containing H2S; (2) reacting the H2S thus obtained in step (1) according to the Claus reaction; (3) concentrating the mercaptans in at least one cut of the said sweetened gas; (4) extracting the mercaptans of the said cut; and further comprising: (5) transforming the mercaptans into dialkyl-disulfide (DSO); (6) hydrogenating DSO into H2S; and (7) reacting the H2S thus obtained at step (6) according to the Claus reaction. An installation for carrying out this procedure is also described.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: February 19, 2008
    Assignee: Total S.A.
    Inventor: Denis Chretien
  • Patent number: 7026372
    Abstract: A composition containing 3,3?-thiobis(propane-1,2-dithiol) and one or more enic compounds which composition is photocurable and can give a cured product having a high refractive index and adequate hardness.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: April 11, 2006
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Kenji Ishii, Hitoshi Okazaki, Mitsuteru Kondo, Masaaki Takasuka, Motoharu Takeuchi
  • Patent number: 6756497
    Abstract: Benzoic acid derivatives useful as intermediates for the preparation of drugs and agricultural chemicals, particularly compounds having herbicidal activity; and easy and economical processes for the preparation of the same. The processes are specifically those represented by reaction formula for the preparation of compounds represented by general formulae (1) and (6).
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: June 29, 2004
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Yuuki Nakagawa, Masao Yamaguchi, Hiroyuki Adachi, Hiroyuki Yamanaka, Tomio Yagihara, Masami Hatano
  • Patent number: 6686506
    Abstract: The invention relates to a process for the preparation of organic disulfides by oxidation of mercaptans with sulfur dissolved in an organic disulfide using an amine as catalyst, where the mercaptans are used as “crude mercaptan stream” from a reaction of alcohols with hydrogen sulfide over a catalyst suitable for mercaptan synthesis. Furthermore, the invention relates to the use of the organic disulfides for the preparation of alkanesulfonic acids.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: February 3, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Werner Hesse, Hans-Josef Sterzel, Christian Tragut
  • Patent number: 6646165
    Abstract: This invention is directed to a process for producing a bishalophenyl disulfide, chracterized by reacting a halothiophenol with an alkali metal hydroxide to obtain an alkali metal halothiophenolate and subsequently converting the halothiophenolate into a disulfide with an oxidizing agent in the presence of a mineral acid. By the process, a bishalophenyl disulfide having a high purity can be industrially produced in high yield.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: November 11, 2003
    Assignee: Sumitomo Seika Chemicals Co., Ltd.
    Inventors: Takehiro Hiyama, Hitoshi Karino, Shinji Nii
  • Patent number: 6518459
    Abstract: A filtering means containing gelatinous and solid materials is cleaned without dismantling the filtering means by contacting the gelatinous material inside the filtering means with a solvent, thereby physically degrading the gelatinous material such that the degraded gelatinous material can pass through the filtering means.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: February 11, 2003
    Assignee: Phillips Petroleum Company
    Inventor: Brooks D. Bennett
  • Patent number: 6399832
    Abstract: Selectively producing organic trisulfides by contacting a mercaptan, a sulfur compound, and a catalyst under conditions sufficient to produce a reaction product comprising organic polysulfides, and subjecting the reaction product to trisulfide enhancing conditions which are effective to inhibit the formation of organic disulfides and promote the conversion of organic tetrasulfides to organic trisulfides.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: June 4, 2002
    Assignee: Phillips Petroleum Company
    Inventor: Brooks D. Bennett
  • Patent number: 6310114
    Abstract: Compact and preferably cellular polyurethane elastomers are produced by reacting a) polyhydroxyl compounds having molecular weights of from 800 to 6000 and, if desired, b) chain extenders and/or crosslinkers having molecular weights of up to 800 [lacuna] c) naphthylene 1,5-diisocyanate and at least one additional aromatic diisocyanate selected from the group consisting of tolylene diisocyanate, diphenylmethane diisocyanate, 3,3′-dimethylbiphenyl diisocyanate, 1,2-diphenylethane diisocyanate and phenylene diisocyanate, and/or aliphatic diisocyanate having from 4 to 12 carbon atoms and/or cycloaliphatic diisocyanate having from 6 to 18 carbon atoms, where the formative components (a), (c) and, if used, (b) are preferably reacted by the prepolymer method, in the presence or absence of d) catalysts, e) blowing agents and f) additives. Isocyanate prepolymers suitable for this purpose are also described.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: October 30, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Manfred Genz, Walter Haselhorst, Torsten Jeschke, Ute Nichau, Heinz Bollmann, Michael Strauss, Wolfgang Scholz, Rüdiger Voelkel, Hartmut Peuker, Gerhard Hellmann
  • Patent number: 6294699
    Abstract: A process useful for producing an organic disulfide is disclosed. The process can include contacting mercaptans with a solid catalyst selected from the group consisting of a Group IIA metal oxide; 2) an alumina material consisting essentially of alumina; 3) an impregnated alumina impregnated with a metal selected from the group consisting of cobalt, molybdenum, tungsten, nickel and combinations of any two or more thereof; 4) an acidic ion-exchange resin; 5) a basic ion-exchange resin; and 6) combinations of any two or more thereof; in the presence of sulfur dioxide and in the substantial absence of a liquid oxidation catalyst to thereby produce organic disulfides.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: September 25, 2001
    Assignee: Richmond, Hitchcock, Fish & Dollar
    Inventors: Mitchell D. Refvik, James Edward Shaw
  • Patent number: 6284926
    Abstract: A filtering means containing gelatinous and solid materials is cleaned without dismantling the filtering means by contacting the gelatinous material inside the filtering means with a solvent, thereby physically degrading the gelatinous material such that the degraded gelatinous material can pass through the filtering means.
    Type: Grant
    Filed: June 6, 2000
    Date of Patent: September 4, 2001
    Assignee: Richmond, Hitchcock, Fish & Dollar
    Inventor: Brooks D. Bennett
  • Patent number: 6242652
    Abstract: Selectively producing organic trisulfides by contacting, in the presence of a catalyst, a mercaptan and a sulfur compound under conditions sufficient to produce a organic polysulfides and hydrogen sulfide and controlling the concentration of hydrogen sulfide in the liquid reaction solution during specific reaction periods such that the production of organic trisulfide is enhanced and the production organic polysulfides having more or less than three sulfur atoms is inhibited.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: June 5, 2001
    Assignee: Phillips Petroleum Company
    Inventor: Brooks D. Bennett
  • Patent number: 6235941
    Abstract: An aqueous solution of basic mercaptide salt and water-soluble peroxide are mixed together in a reaction zone and maintained under reaction conditions effective to produce a vapor phase comprising organic disulfide, and concurrently vapor phase is recovered from the reaction zone. The process is highly efficient and enables production of organic disulfides in high yield and purity. Not only is the process very easy and simple to carry out, but in addition the process (i) eliminates the need for forming an organic phase of liquid organic disulfide product and conducting a separation between such product and the total aqueous phase used in the reaction, (ii) enables efficient control of a highly exothermic reaction, and (iii) minimizes alkanesulfonic acid salt formation during the reaction.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: May 22, 2001
    Assignee: Albemarle Corporation
    Inventors: Chi Hung Cheng, Gerald M. Sulzer
  • Patent number: 6218578
    Abstract: The invention relates to a polymeric film composed of an optically anisotropic material made from a cross-linked synthetic resin composition comprising a polymer network, being obtainable by copolymerization of a mixture comprising (a) at least one monomer or oligomer, each of said monomers or oligomers having at least two polymerizable functional groups selected from the group consisting of (meth-)acrylate ester, epoxy and vinyl ether, (b) at least one achiral liquid crystalline monomer or oligomer, each of said monomersloligomers having mesogenic groups and one polymerizable functional group selected from the group consisting of (meth-)acrylate ester, epoxy and vinyl ether.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: April 17, 2001
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: David Coates, Simon Greenfield, Emma Jane Jolliffe
  • Patent number: 6187960
    Abstract: A process which can be used to produce organic polysulfide compounds is provided. The process comprises contacting, in the presence of a catalyst, an organic disulfide with sulfur under conditions sufficient to produce an organic polysulfide wherein the organic disulfide, sulfur, and catalyst are each present in an amount effective to produce an organic polysulfide and the catalyst comprises a base and a surfactant.
    Type: Grant
    Filed: February 14, 1995
    Date of Patent: February 13, 2001
    Assignee: Phillips Petroleum Company
    Inventor: James E. Shaw
  • Patent number: 6169210
    Abstract: A highly efficient method of producing dialkyl disulfides from mercaptans and oxygen is described which involves employing carbon dioxide as an internal coolant. Among the benefits made possible by this method are (1) an increase in the proportion of mercaptan converted to dialkyl disulfide per pass through the reactor, (2) an increased ease of separation of and recycling of carbon dioxide, (3) the ability to use a common contaminant as a coolant, and (4) the use of a simple adiabatic reactor design.
    Type: Grant
    Filed: April 20, 1999
    Date of Patent: January 2, 2001
    Inventor: Kaung-Far Lin
  • Patent number: 6133481
    Abstract: Improved low density polyurethane foams are prepared from an isocyanate-terminated prepolymer having an NCO content of more than about 31 to about 33.5% by weight comprising:(a) a polyphenylene polymethylene polyisocyanate comprising(i) about 30 to about 100% by weight of diphenylmethane diisocyanate and(ii) the remainder selected from the group consisting essentially of higher homologues of polyphenylene polymethylene polyisocyanate, isocyanate-containing ester groups, urea groups, biuret groups, aliphatic groups, carbodiimide groups, isocyanurate groups, uretdione groups and urethane groups; and(b) a polyoxyalkylene polyol having an oxyethylene content of about 30 to about 90%, a molecular weight of about 1000 to about 12000 and a functionality of about 2 to about 8.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: October 17, 2000
    Inventors: Sachchida Nand Singh, Michael John Cartmell, James Holloway
  • Patent number: 6114537
    Abstract: Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at position N-2. The process is useful pharmacologically, in inhibiting certain thiol-containing enzymes such as H.sup.+ /K.sup.+ -ATPase (the proton pump), and industrially, in selective removal of thiol compounds from gas or liquid mixtures.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: September 5, 2000
    Assignee: Apotex Inc.
    Inventors: Khashayar Karimian, Tim F. Tam, Denis Desilets, Sue Lee, Tullio Cappelletto, Wanren Li
  • Patent number: 6054621
    Abstract: The invention relates to novel alkoxyacrylic thiol esters, to a plurality of processes for their preparation and to their use as fungicides, and to novel intermediates and to a plurality of processes for their preparation.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: April 25, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Gayer, Peter Gerdes, Ulrich Heinemann, Bernd-Wieland Kruger, Ralf Tiemann, Klaus Stenzel, Stefan Dutzmann, Gerd Hanssler
  • Patent number: 6051739
    Abstract: A process for producing an organic polysulfide compound comprises contacting, in the presence of a catalyst, a mercaptan with elemental sulfur to produce a product medium and contacting the product medium with a material comprising carbon dioxide or a carbon dioxide-generating compound wherein the catalyst comprises a base and optionally a surfactant and the organic polysulfide contains about 3 or more sulfur atoms per molecule.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: April 18, 2000
    Assignee: Phillips Petroleum Company
    Inventor: James E. Shaw
  • Patent number: 6020529
    Abstract: A process for the manufacture of organic disulphides and polysulphides using a basic resin catalyst wherein the catalyst is a polystyrene-divinylbenzene resin functionalized with ethylenediamine or a polyethylenepolyamine groups.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: February 1, 2000
    Assignee: Elf Atochem S.A.
    Inventor: Georges Fremy
  • Patent number: 5998670
    Abstract: Disclosed is a method of making a substituted diphenyldisulfide from a substituted thiophenol. A two phase reaction mixture is prepared which comprises a substituted thiophenol having the general formula ##STR1## hydrogen peroxide, water, an organic solvent, a basic salt that will give a pH between about 7 and about 10, and an optional flocculating agent. In the formula, R is selected from the group consisting of halogen, alkyl from C.sub.1 to C.sub.6, alkoxy from C.sub.1 to C.sub.6, or nitro. After the exothermic reaction is complete, the reaction mixture is cooled to crystallize the substituted diphenyldisulfide product. The symmetrical product precipitates preferentially over the unsymmetrical product, thereby enhancing the purity of the product over the purity of the starting material. Optionally, the organic solvent and the aqueous phase are recycled.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: December 7, 1999
    Assignee: Occidental Chemical Corporation
    Inventors: David Y. Tang, Michael C. Hausladen, Viktor D. Sorokin
  • Patent number: 5986143
    Abstract: The present invention relates to a method of producing bis(4-alkylthiophenyl) disulfides characterized by (a) reducing directly a 4-alkylthiobenzenesulfonyl chloride, or (b) oxidizing a 4-alkylthiobenzenethiol obtained by reducing a 4-alkylthiobenzenesulfonyl chloride. The present invention is capable of producing the compound below useful as an intermediate of pharmaceuticals.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: November 16, 1999
    Assignee: Toray Industries, Inc.
    Inventors: Hiromi Uchiro, Norio Kawabe, Kouichi Tsuruta, Teiji Kawano
  • Patent number: 5922902
    Abstract: A process for synthesizing disulfides and sulfhydryl compounds which are useful pharmaceuticals. The process includes a two step, single pot process for preparing disulfides from an alkenyl sulfonate salt. The disulfides are useful as toxicity mitigating agents of chemotherapeutic drugs, such as certain platinum complexes, and as use therapeutic drugs for a variety of conditions in mammals.The two step process involves first the conversion of the starting reagent to a mercaptane sulfonate, then an oxidation to the desired disulfide.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: July 13, 1999
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Kochat Haridas
  • Patent number: 5861539
    Abstract: A composition comprising a base and an alkoxylated compound selected from an alkoxylated alcohol and alkoxylated mercaptan is disclosed. The composition can be used to catalyze the reaction of a mercaptan and an elemental sulfur to produce a polysulfide compound. The polysulfide compound can be further treated with an alkylene oxide to reduce the mercaptan sulfur content of the polysulfide compound.
    Type: Grant
    Filed: August 28, 1997
    Date of Patent: January 19, 1999
    Assignee: Phillips Petroleum Company
    Inventor: James E. Shaw
  • Patent number: 5808140
    Abstract: A process for synthesizing disulfides and sulfhydryl compounds which are useful pharmaceuticals. The process includes a two step, single pot process for preparing disulfides from an alkenyl sulfonate salt. The disulfides are useful as toxicity mitigating agents of chemotherapeutic drugs, such as certain platinum complexes, and as use therapeutic drugs for a variety of conditions in mammals.The two step process involves first the conversion of the starting reagent to a mercaptane sulfonate, then an oxidation to the desired disulfide.
    Type: Grant
    Filed: September 24, 1997
    Date of Patent: September 15, 1998
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Kochat Haridas
  • Patent number: 5786511
    Abstract: The preparation of organic disulphides and polysulphides by reaction of sulphur with a mercaptan or with a polysulphide of lower sulphur order in order to convert it into polysulphide of higher order, or alternatively by reaction of a mercaptan with an organic polysulphide of high sulphur order in order to convert it into polysulphide of lower sulphur order, in the presence of a catalyst in the form of a resin with a basic function, characterized in that the resin is based on polystyrene-divinylbenzene (PS-DVB) functionalized with primary amino groups and having the general formula (I): ##STR1## being the PS-DVB resin support, L being a linear organic radical which is as long as or longer than the methylene radical (--CH.sub.2 --).
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: July 28, 1998
    Assignee: Elf Aquitaine Production
    Inventor: Emmanuel Arretz
  • Patent number: 5767229
    Abstract: In a process for the preparation of organic disulphides and polysulphides by reaction of sulphur with a mercaptan or with a polysulphide of lower sulphur order in order to convert it into polysulphide of higher order, or alternatively by reaction of a mercaptan with an organic polysulphide of a high sulphur order in order to convert it into a polysulphide of lower sulphur order, in the presence of a catalyst in the form of a resin with a basic function, the resin is based on a polystyrene-divinyl benzene support functionalized with guanidine or amidine groups, and the reaction is preferably conducted in the presence of methanol.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: June 16, 1998
    Assignee: Elf Aquitaine Production
    Inventors: Emmanuel Arretz, Frederic Lopez
  • Patent number: 5659086
    Abstract: A process which can be used for producing an organic disulfide is provided. The process comprises the steps of: (1) contacting a base and a mercaptan under an effective condition for forming a brine phase comprising the base and a basic salt of a mercaptan; (2) contacting the brine phase with a mercaptan and hydrogen peroxide under a condition sufficient to effect the formation of an aqueous phase and an organic phase; (3) separating the aqueous phase from the organic phase; (4) recovering the organic phase; and optionally, (5) removing a portion of water from the aqueous phase and thereafter repeating the steps of (2) to (5).
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 19, 1997
    Assignee: Phillips Petroleum Company
    Inventors: Alex Pauwels, Dean E. Stinn
  • Patent number: 5565517
    Abstract: A process for preparing an organic polysulfide polymer, such as polyethylene trisulfide, is provided which comprises contacting a dimercaptan such as 1,2-ethanedithiol with elemental sulfur using a basic catalyst wherein the dimercaptan, elemental sulfur, and basic catalyst are each present in an effective amount to effect the preparation of the organic polysulfide polymer. A process for controlling the molecular weight of an organic polysulfide polymer is also provided which comprises contacting a mercaptan with a dimercaptan and sulfur, in the presence of a basic catalyst, under conditions sufficient to prepare an organic polysulfide polymer.
    Type: Grant
    Filed: November 16, 1994
    Date of Patent: October 15, 1996
    Assignee: Phillips Petroleum Company
    Inventors: Howard F. Efner, James E. Shaw
  • Patent number: 5530163
    Abstract: A process which can be used to produce organic polysulfide compounds is provided. The process comprises contacting, in the presence of a catalyst, a mercaptan with sulfur under conditions sufficient to produce an organic polysulfide and thereafter, the resulting reaction medium is contacted with an acid to produce an acid-treated organic polysulfide wherein the mercaptan, sulfur, and catalyst are each present in an amount effective to produce an organic polysulfide. The acid-treated organic polysulfide can be purified and recovered.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: June 25, 1996
    Assignee: Phillips Petroleum Company
    Inventor: James E. Shaw
  • Patent number: 5463042
    Abstract: A layered double hydroxide intercalated with a metal complex of a polyaryl compound is described. A preferred complex is porphin or phthylocyanine. The metals are preferably selected from Group VII-B and Group VIII cobalt and iron triads. The resulting LDH metal complexes are useful for the oxidation of oxidate compounds such as thiols and phenols.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: October 31, 1995
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Thomas J. Pinnavaia, Elena M. Perez-Bernal, Ricardo Ruarno-Casero, Malama Chibwe
  • Patent number: 5442123
    Abstract: A process for producing a substantially pure organic trisulfide from mercaptan and sulfur (or high rank organopolysulfide) wherein the sulfur is reacted with mercaptan in the presence of a heterogeneous alumina-based catalyst, ammonium, alkali metal or alkaline earth metal modified silica-based catalyst, zinc-based catalyst or mixtures thereof, and recovering a product containing at least a major proportion of trisulfide.
    Type: Grant
    Filed: January 13, 1993
    Date of Patent: August 15, 1995
    Assignee: Elf Atochem North America, Inc.
    Inventors: Emmanuel F. Arretz, Glenn T. Carroll, Roger T. Clark
  • Patent number: 5312993
    Abstract: The invention relates to the manufacture of dimethyl disulphide from methyl mercaptan and sulphur. The process according to the invention is characterized in that it comprises:(a) a first reaction zone in which the methyl mercaptan and sulphur are introduced and reacted in the presence of a catalyst,(b) a degassing zone in which the products originating from the first reaction zone are treated to remove at least partially the dissolved hydrogen sulphide, and(c) a second reaction zone in which the products originating from the degassing zone are brought into contact with a catalyst.
    Type: Grant
    Filed: October 29, 1992
    Date of Patent: May 17, 1994
    Assignee: Elf Atochem S.A.
    Inventor: Emmanuel Arretz