Sulfur Bonded Directly To Sulfur (e.g., Disulfides, Etc.) Patents (Class 568/21)
  • Patent number: 10294200
    Abstract: A composition comprising polysulfides, wherein at least about 50 wt. % of the polysulfides are branched C20 to C60 polysulfides represented by general formula R15S1—[S]n—S2R16 wherein R15 and R16 are each independently a branched C10 to C30 alkyl group and wherein n is an integer from 1 to 10. A process of producing a polysulfides crude product comprising one or more branched C20 to C60 polysulfides comprising: (A) reacting a feedstock comprising one or more branched C10 to C30 mercaptans and sulfur in the presence of a catalyst and (B) collecting the polysulfides crude product.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: May 21, 2019
    Assignee: Chevron Phillips Chemical Company, LP
    Inventors: Jason L. Kreider, R. Shawn Childress, Michael S. Matson, Jim D. Byers
  • Patent number: 9745263
    Abstract: The present invention relates to a novel use of magnetic iron oxide red Fe21.333O32 as a catalyst in oxidizing methanthiol to prepare dimethyl disulfide. The magnetic iron oxide red Fe21.333O32 according to the present invention has extremely high catalytic selectivity in catalyzing and oxidizing methanthiol to prepare dimethyl disulfide. The magnetic iron oxide red Fe21.333O32 is prepared with a carbonate and a ferrite as raw materials, has advantages of low cost and simple preparation process, and is suitable for industrial production.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: August 29, 2017
    Assignee: BEIJING SJ ENVIROMENTAL PROTECTION AND NEW MATERIAL CO., LTD.
    Inventors: Wenwen Song, Liying Li, Wenjun Mao, Zhimin Zhang, Zhenyi Liu
  • Patent number: 9296890
    Abstract: The curable composition is a curable composition including a liquid polysulfide polymer containing 8% by weight or more of thiol groups in one molecule, an epoxy resin, and an amine, in which the liquid polysulfide polymer is HS—(R—Sx)n—R—SH wherein R is a two valent or three valent organic group containing a —O—CH2—O— bond, the average of n is less than 10, x is an integer of 1 to 5, and the average of x is 1 to 2.5.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: March 29, 2016
    Assignee: Toray Fine Chemicals Co., Ltd.
    Inventors: Yasukazu Suga, Yukiko Hamada, Kazunori Matsumoto, Rika Umano
  • Patent number: 8987519
    Abstract: The present disclosure relates to a process for obtaining dialkyl disulphides from alkyl mercaptan and from sulphur, in which a reaction intermediate present in the final disulphide is decomposed at the end of synthesis. This operation makes it possible to avoid the degradation of said reaction intermediate over time, which is responsible for the decrease in purity of the dialkyl disulphide.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: March 24, 2015
    Assignee: Arkema France
    Inventors: Georges Fremy, Jean-Michel Raymond
  • Patent number: 8952124
    Abstract: Bis(sulfonyl)alkanol-containing polythioethers, compositions containing bis(sulfonyl)alkanol-containing polythioethers, methods of synthesizing bis(sulfonyl)alkanol-containing polythioethers and the use of bis(sulfonyl)alkanol-containing polythioethers in aerospace sealant applications are disclosed. The bis(sulfonyl)alkanol-containing polythioethers have bis(sulfonyl)alkanol groups incorporated into the backbone of the polythioether. Cured sealant compositions comprising the bis(sulfonyl)alkanol-containing polythioethers exhibit enhanced properties suitable for aerospace sealant applications.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: February 10, 2015
    Assignee: PRC-DeSoto International, Inc.
    Inventors: Chandra Rao, Juexiao Cai, Renhe Lin
  • Patent number: 8912306
    Abstract: A halogen-terminated sulfur-containing polymer is represented by: X—(R—Sr)n—R—X wherein R is an ether bond-containing alkyl group having 3 to 26 carbon atoms, X is a halogen atom, n is an integer of 1 to 200, and r has an average of 1 to 5.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: December 16, 2014
    Assignee: Toray Fine Chemicals Co., Ltd.
    Inventors: Yukiko Hamada, Yasukazu Suga, Koki Echigoya, Kazunori Matsumoto, Tomohiro Oba
  • Patent number: 8877830
    Abstract: The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material or during polymerization of a polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides mixtures for making crosslinked polymeric materials, methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention. The mixtures of the invention may be dental restorative compositions used for forming dental restorative materials.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: November 4, 2014
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Christopher N. Bowman, Christopher Kloxin, Hee Young Park, Diana Leung
  • Patent number: 8791292
    Abstract: One subject of the invention is a dimethyl disulphide in which the content of biocarbon is at least 1%. Another subject of the invention is processes for preparing this dimethyl disulphide. Yet another subject of the invention is the use of such a dimethyl disulphide for the manufacture of methanesulphonic acid.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: July 29, 2014
    Assignee: Arkema France
    Inventors: Christian Forquy, Georges Fremy
  • Patent number: 8658833
    Abstract: A method of producing polysulfides comprising the step of adding elemental sulphur to an allicin-containing plant extract. In preferred embodiments, the plant extract is mechanically treated members of the genus Allium, especially garlic. In further preferred aspects of the invention, the plant extract and sulphur mixture is heated, and the pH is controlled to allow manipulation of the polysulfide chain length. The addition of organic bases, containing nitrogen lone pairs, allows further control of polysulfide chain length.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: February 25, 2014
    Assignee: Ecospray Limited
    Inventors: Eric Block, Murree Groom
  • Patent number: 8580998
    Abstract: Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene without isomerization or the need to chromatographically purify the final product By selectively blocking the amino and carboxy groups of the derivatized amino acid, the methods of the disclosure provide for the synthesis of a peptide having the vinylglycine moiety at either the carboxy or the amino terminus of the peptide The mild conditions for the thermolytic removal of an o-NO2-phenyl substituted aryl group ensure that there is minimal if any damage to thermally sensitive conjugates such as a peptide bearing the vinylglycine The methods of the present disclosure have practical applications for the preparation of unsaturated compounds under mild, thermolytic conditions.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: November 12, 2013
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Timothy Edward Long, Sravan Kumar Patel
  • Publication number: 20130267739
    Abstract: The present disclosure relates to a process for obtaining dialkyl disulphides from alkyl mercaptan and from sulphur, in which a reaction intermediate present in the final disulphide is decomposed at the end of synthesis. This operation makes it possible to avoid the degradation of said reaction intermediate over time, which is responsible for the decrease in purity of the dialkyl disulphide.
    Type: Application
    Filed: September 30, 2011
    Publication date: October 10, 2013
    Applicant: Arkema France
    Inventors: Georges Fremy, Jean-Michel Raymond
  • Patent number: 8470197
    Abstract: A crosslinked polysulfide-containing cycloaliphatic compound, useful as a crosslinker for filled sulfur-vulcanizable elastomer compositions, is represented by the general formula: [(CaH2a-)mG1(-CbH2bSx—)n?m]o[CcH2c-G2-CdH2dSy—]p[R]q wherein G1 is a saturated, monocyclic aliphatic group of valence n containing from 5 to 12 carbon atoms and optionally containing at least one halogen or a saturated monocyclic silicone [RSiO—]n[R2SiO—]r group of valence n; G2 is a saturated, divalent cyclic aliphatic group of valence 2 containing from 5 to 12 carbon atoms and optionally containing at least one halogen or a saturated monocyclic silicone [RSiO—]n[R2SiO—]r group of valence n; each R independently is a selected from the group consisting of a hydrogen atom, monovalent hydrocarbon of up to 20 carbon atoms and a halogen atom; each occurrence of subscripts a, b, c, d, m, n, o, p, q, x and y independently is an integer wherein a is 2 to 6; b is 2 to 6; c is 1 to 6; d is 1 to 6; m is 1 or 2; n is 3 to 5; o is a positive
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: June 25, 2013
    Assignee: Momentive Performance Materials Inc.
    Inventors: Richard W. Cruse, William Michael York, Carla Recker, Thomas Kramer, Katharina Herzog
  • Patent number: 8455552
    Abstract: The present invention relates to S-allylmercapto-N-acetylcysteine (ASSNAC) and its pharmaceutically acceptable salts and solvates, which are useful for up-regulation of cellular glutathione levels and expression of phase II detoxifying enzymes. The invention further provides methods of use thereof in the prevention, alleviation or treatment of oxidative stress induced by reactive oxygen species (ROS).
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: June 4, 2013
    Assignees: RAMOT et Tel Aviv University Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Naphtali Savion, David Mirelman, Aharon Rabinkov, Alex Khenkin
  • Patent number: 8426648
    Abstract: The present invention relates to a hydrogenation catalyst, particularly useful for the hydrogenation of carbon disulphide (CS2) to form methyl mercaptan (CH3SH), and to a preparation method thereof. The present invention also relates to a method for continuously preparing methyl mercaptan by the catalytic hydrogenation of carbon disulphide, with a carbon disulphide conversion rate of 100%, and a methyl mercaptan selectivity of 100%.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: April 23, 2013
    Assignee: Arkema France
    Inventors: Patrice Barre, Georges Fremy, Andre Lozowski
  • Patent number: 8227517
    Abstract: Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: July 24, 2012
    Assignee: Tosk, Incorporated
    Inventors: William A. Garland, Brian D. Frenzel
  • Patent number: 8101802
    Abstract: Diallylic polysulfides (polysulfanes) are provided with sulfur chain lengths of 9 to 22. Also provided are bis(2-methyl-2-propenyl) polysulfides with sulfur chain lengths of 3 to 22. Also provided are 2-substituted bis(2-propenyl) polysulfides with sulfur chain lengths of 3 to 20. Also provided are the 2-cycloalken-1-yl polysulfides, 2-cyclohexen-1-yl polysulfides and 2-cyclopenten-1-yl polysulfides, with sulfur chain lengths of 3 to 20. Also provided are processes for extending the sulfur chain length of diallylic polysulfides and 2-substituted analogues thereof and allyl methyl polysulfides by bringing such compounds into contact with elemental sulfur and heating, or by mixing with molten sulfur.
    Type: Grant
    Filed: November 12, 2007
    Date of Patent: January 24, 2012
    Assignee: ECOspray Limited
    Inventors: Murree Groom, Eric Block
  • Publication number: 20120016096
    Abstract: A sulfur-containing anionic polymerization initiator defined by the formula: R1?S—R2?aR3?Li? where R1 is a monovalent organic group, R2 is a divalent organic group, R3 is a divalent organic group or a bond, and a is an integer from 1 to about 5.
    Type: Application
    Filed: September 28, 2011
    Publication date: January 19, 2012
    Inventors: Terrence E. Hogan, William L. Hergenrother
  • Patent number: 8080605
    Abstract: Polymer-filler coupling compounds with the formula B-A-Sx—N are claimed. In these compounds, B is an azaheterocyclic oxygen or sulfur containing moiety, or an allyltin moiety; Sx is a polysulfide, where x is between 2 and about 10; A is a linking atom or group that forms a bridge between B and Sx; and N is a blocking group. Sx can be a disulfide. N can be a conventional blocking group or other group such as -A-B. Methods for using the polymer-filler coupling compounds to modify polymers containing unsaturated carbon-carbon bonds and promote filler dispersion are also claimed. Additionally, vulcanizable rubber compositions containing the polymer-filler coupling compounds and methods for making vulcanized rubber compositions using the polymer-filler coupling compounds are also claimed.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: December 20, 2011
    Assignee: Bridgestone Corporation
    Inventors: Yasuo Fukushima, William L. Hergenrother, Russell W. Koch
  • Patent number: 8076519
    Abstract: The present invention relates to the masking of the odor of organic sulphides and more particularly that of alkyl sulphides or of dialkyl sulphides, especially dimethyl sulphide, and also of oxides thereof, and especially of dimethyl sulphoxide, by addition, to said organic sulphides, of at least one odor-masking agent comprising at least one monoester, at least one di- or triester, at least one alcohol, at least one ketone and, optionally, at least one terpene.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: December 13, 2011
    Assignee: Arkema France
    Inventor: Paul-Guillaume Schmitt
  • Patent number: 8063155
    Abstract: The invention relates to a sulphur donor curing agent comprising a combination of between 10 and 90 wt % of a mixture of polysulphides of poly(alkyl phenol) and between 90 and 10 wt. % a compound of the formula R?NHCONHR? were R? and R? are the same or different and are hydrogen oa an alkyl or aryl radical having 1 to 20 carbon atoms and methods of curing an EPDM-type rubber elastomer with the composition which presents no risk of the formation of nitrosamines.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: November 22, 2011
    Assignee: Arkema France
    Inventor: Thierry Aubert
  • Publication number: 20110263894
    Abstract: A process for compressing a hydrogen-sulfide-comprising gas stream, which comprises (i) compressing the hydrogen-sulfide-comprising gas stream in a compressor, (ii) flushing the compressor with a mixture comprising dialkyl polysulfides, dialkyl disulfides and at least one amine; a process for producing sulfur compounds, selected from the group consisting of alkylmercaptans, dialkyl disulfides and alkanesulfonic acids, which comprises the conversion of hydrogen-sulfide-comprising gas streams, wherein the hydrogen-sulfide-comprising gas streams are compressed according to the process comprising steps i) and ii); and also the use of a mixture comprising dialkyl polysulfides, dialkyl disulfides and at least one amine for removing sulfur deposits which occur in the compression of hydrogen-sulfide-comprising gas streams.
    Type: Application
    Filed: December 22, 2009
    Publication date: October 27, 2011
    Applicant: BASF SE
    Inventors: Andreas Woelfert, Frank Grzonkowski, Harald Jachow, Guenter Renz
  • Publication number: 20110172138
    Abstract: One subject of the invention is a dimethyl disulphide in which the content of biocarbon is at least 1%. Another subject of the invention is processes for preparing this dimethyl disulphide. Yet another subject of the invention is the use of such a dimethyl disulphide for the manufacture of methanesulphonic acid.
    Type: Application
    Filed: August 18, 2009
    Publication date: July 14, 2011
    Applicant: ARKEMA FRANCE
    Inventors: Christian Forquy, Georges Fremy
  • Publication number: 20100274037
    Abstract: Diallylic polysulfides (polysulfanes) are provided with sulfur chain lengths of 9 to 22. Also provided are bis(2-methyl-2-propenyl) polysulfides with sulfur chain lengths of 3 to 22. Also provided are 2-substituted bis(2-propenyl) polysulfides with sulfur chain lengths of 3 to 20. Also provided are the 2-cycloalken-1-yl polysulfides, 2-cyclohexen-1-yl polysulfides and 2-cyclopenten-1-yl polysulfides, with sulfur chain lengths of 3 to 20. Also provided are processes for extending the sulfur chain length of diallylic polysulfides and 2-substituted analogues thereof and allyl methyl polysulfides by bringing such compounds into contact with elemental sulfur and heating, or by mixing with molten sulfur.
    Type: Application
    Filed: November 12, 2007
    Publication date: October 28, 2010
    Inventors: Murree Groom, Eric Block
  • Publication number: 20100203001
    Abstract: The present invention relates to an improved method of formation of disulfide bridges in substances bearing SH groups, in particular peptides, for example by formation of intramolecular disulfide bridges, in which a heterocyclic compound having at least one nitrogen atom (e.g. caffeine or a caffeine-like substance) is used for catalysis of the reaction. It was found, surprisingly, that addition of the heterocyclic substance increases both the yield and the purity of the product bearing disulfide bridges.
    Type: Application
    Filed: December 21, 2007
    Publication date: August 12, 2010
    Applicant: APLAGEN GMBH
    Inventors: Karsten Knorr, Marco Emgenbroich, Carsten Büngener
  • Publication number: 20100204337
    Abstract: Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.
    Type: Application
    Filed: April 22, 2010
    Publication date: August 12, 2010
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Edward Turos, Praveen Ramaraju
  • Patent number: 7674444
    Abstract: A sulfur species-containing feed gas is processed in a treatment plant in which COS is hydrolyzed, and in which so produced hydrogen sulfide and other sulfur species are absorbed in a lean hydrocarbon liquid. The sulfur species in the so formed rich hydrocarbon liquid are then subjected to catalytic conversion into disulfides, which are subsequently removed from the rich solvent. Most preferably, sulfur free lean solvent is regenerated in a distillation column and/or refinery unit, and light components are recycled from the rich hydrocarbon liquid to the absorber.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: March 9, 2010
    Assignee: Fluor Technologies Corporation
    Inventor: John Mak
  • Patent number: 7662478
    Abstract: Provided is a polymer comprising a repeating unit represented by formula (1), wherein, A1 represents a divalent group in which the bond distance ratio (bond distance of C(?)-A1/bond distance of C(?)-C(?)) is 1.10 or more; R1, R2, R3, R4, R5, and R6, each independently represent a hydrogen atom, alkyl group, alkyloxy group, aryloxy group, arylalkyloxy group, etc. The polymer is useful as a light-emitting material, a charge transporting material, etc.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: February 16, 2010
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Satoshi Kobayashi, Takanobu Noguchi, Yoshiaki Tsubata, Makoto Kitano, Shuji Doi, Takahiro Ueoka, Akiko Nakazono
  • Patent number: 7332145
    Abstract: Disclosed is a process for the treatment of gas containing mercaptans and acid gases, including the following steps: (1) separating the acid gases from the said gas and obtaining a sweetened gas and the flow of acid gases containing H2S; (2) reacting the H2S thus obtained in step (1) according to the Claus reaction; (3) concentrating the mercaptans in at least one cut of the said sweetened gas; (4) extracting the mercaptans of the said cut; and further comprising: (5) transforming the mercaptans into dialkyl-disulfide (DSO); (6) hydrogenating DSO into H2S; and (7) reacting the H2S thus obtained at step (6) according to the Claus reaction. An installation for carrying out this procedure is also described.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: February 19, 2008
    Assignee: Total S.A.
    Inventor: Denis Chretien
  • Patent number: 7319124
    Abstract: The invention relates to novel organic sulphur-nitrogen compounds, their preparation, and use as vulcanizing agents for unsaturated rubbers and mixtures of these.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: January 15, 2008
    Assignee: LANXESS Deutschland GmbH
    Inventors: Hermann-Josef Weidenhaupt, Hartmuth Buding, Josef Hahn, Andreas Mihalyi, Uwe Zettl
  • Patent number: 7235697
    Abstract: The present invention relates to a process for preparing sulfur-containing compounds of the general formula I in which Q, R1 and R2 are each independently defined as follows: Q: —S— or —S—S—, R1: hydrogen or saturated or unsaturated, linear or branched C1-C30-alkyl radical, R2: hydrogen or saturated or unsaturated, linear or branched C1-C30-alkyl radical, where R1 and R2 are not simultaneously hydrogen, by reacting a mixed gas stream comprising hydrogen sulfide, with or without oxygen, with linear or branched C1-C30-olefins, which comprises carrying out the reaction in the presence of water and carbon dioxide at a pressure of from 2 to 325 bar.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: June 26, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Christian Müller, Markus Weber, Eckhard Stroefer
  • Patent number: 7189867
    Abstract: A compound having the formula CF3—CH(OH)—CH2—(L)n—CH2—SH or a disulfide thereof. Each L is substituted or unsubstituted methylene, substituted or unsubstituted oxyalkylene, and alkyl-substituted or unsubstituted siloxanylene. The compound is free of carboxysilane linkages. The value of n is a positive integer. A metal surface having the group CF3—CH(OH)—CH2—(L)n—CH2—S— bound thereto. A method of making CF3—CH(OH)—CH2—(L)n—CH2—SH by: reacting OHC—CH2—(L)n—CH2—X with (trifluoromethyl)trialkylsilane to form CF3—CH(OH)—CH2—(L)n—CH2—X; reacting the intermediate with a thiocarbonyl compound to form an adduct; and hydrolyzing the adduct followed by protonation. X is a halogen.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: March 13, 2007
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: James H Wynne, Arthur W Snow
  • Patent number: 7087787
    Abstract: The invention relates to a method for producing derivatives of 4-alkylsulfinyl methylarylene methanols. Derivatives of 4-alkylsulfinyl methylarylene methanols are valuable monomers in the production of conjugated polymers, which are suitable for use as electroluminescent materials.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: August 8, 2006
    Assignee: Covion Organic Semiconductors GmbH
    Inventors: Dirk Vanderzande, Joanes Gelan, Albert van Breemen, Michael Van Der Borght, Laurence Lutsen, Raf Kiebooms, Willi Kreuder
  • Patent number: 7026372
    Abstract: A composition containing 3,3?-thiobis(propane-1,2-dithiol) and one or more enic compounds which composition is photocurable and can give a cured product having a high refractive index and adequate hardness.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: April 11, 2006
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Kenji Ishii, Hitoshi Okazaki, Mitsuteru Kondo, Masaaki Takasuka, Motoharu Takeuchi
  • Patent number: 6989263
    Abstract: The present invention provides several classes of compounds which can be used to inactivate retroviruses, such as HIV-1, by attacking the CCHC zinc fingers of the viral nucleocapsid protein and ejecting the zinc therefrom. In addition, kits for identifying compounds that can react with CCHC zinc fingers of the nucleocapsid proteins of a large number of different retroviruses have also been developed. The kits of the present invention describe a set of specific tests and reagents that can be used to screen and identify compounds based on their ability to react with and disrupt retroviral zinc fingers in the viral NC proteins and, in turn, inactivate the retrovirus of interest.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: January 24, 2006
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Louis E. Henderson, Larry O. Arthur, William G. Rice
  • Patent number: 6960674
    Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: November 1, 2005
    Assignee: The Brigham & Women's Hospital, Inc.
    Inventor: Charles N. Serhan
  • Patent number: 6939941
    Abstract: A process is provided for the manufacture of liquid polysulfide polymers. In particular, the process allows for making the liquid form of the polysulfide polymer directly and eliminates the need to first make a solid polysulfide polymer and then convert it to a liquid.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: September 6, 2005
    Assignee: Toray Fine Chemicals Co., Ltd.
    Inventors: John Richard Gilmore, Keith Bradley Potts, Steven John Hobbs, Marc Edward Halpern, Thomas Dennis Mundle
  • Patent number: 6906171
    Abstract: The synthesis of peptides comprising disulphide bridges is challenging since it is difficult to ensure that the correct cysteine residues combine to form the desired disulphide bridges. The present invention describes novel protection techniques useful in the preparation of peptides. Described is a process for the deprotection of an Acm-, MBzl- and/or tBu-protected thiol which comprises reacting said protected thiol with an acid in the presence of an oxidising agent at a temperature sufficient to effect deprotection and generation of disulphide bonds.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: June 14, 2005
    Assignee: Amersham Health AS
    Inventor: Alan Cuthbertson
  • Patent number: 6894194
    Abstract: In a process to make dithiodiglycol by oxidation of ?-mercaptoethanol with sulfur, an improved product is recovered when a 1-10 mol % excess of ?-mercaptoethanol is used and hydrogen sulfide is removed by vacuum or nitrogen sparge. A typical product contains 88.1 mol % (92.0 wt %) dithiodiglycol, 2.3 mol % (2.9 wt %) trithiodiglycol and 9.6 mol % (5.1 wt %) unreacted ?-mercaptoethanol. Reaction of this product with 35 to 50 wt % solution hydrogen peroxide reduces residual ?-mercaptoethanol to less than 0.02 wt % mercaptan. Residual water of about 3.6 wt % after hydrogen peroxide treatment is reduced to less than 1 wt % by vacuum stripping and/or nitrogen sparge or with a wiped film evaporator.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: May 17, 2005
    Assignee: Chevron Phillips Chemical Company
    Inventors: Kenneth E. Inkrott, Michael S. Matson, Alex Pauwels
  • Patent number: 6803406
    Abstract: Disclosed are compounds comprising both disulfide functionality and electron donor functionality or alkoxy siloxane functionality, and curable compositions comprising compounds comprising both disulfide functionality and electron donor functionality, or electron acceptor functionality, or alkoxy siloxane functionality.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: October 12, 2004
    Assignee: National Starch and Chemical Investmnet Holding Corporation
    Inventor: Osama M. Musa
  • Publication number: 20040116748
    Abstract: In a process to make dithiodiglycol by oxidation of &bgr;-mercaptoethanol with sulfur, an improved product is recovered when a 1-10 mol % excess of &bgr;-mercaptoethanol is used and hydrogen sulfide is removed by vacuum or nitrogen sparge. A typical product contains 88.1 mol % (92.0 wt %) dithiodiglycol, 2.3 mol % (2.9 wt %) trithiodiglycol and 9.6 mol % (5.1 wt %) unreacted &bgr;-mercaptoethanol. Reaction of this product with 35 to 50 wt % solution hydrogen peroxide reduces residual &bgr;-mercaptoethanol to less than 0.02 wt % mercaptan. Residual water of about 3.6 wt % after hydrogen peroxide treatment is reduced to less than 1 wt % by vacuum stripping and/or nitrogen sparge or with a wiped film evaporator.
    Type: Application
    Filed: December 8, 2003
    Publication date: June 17, 2004
    Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY
    Inventors: Kenneth E. Inkrott, Michael S. Matson, Alex Pauwels
  • Patent number: 6743951
    Abstract: A composition based on dimethyl disulphide (DMDS) with a masked smell according to the invention comprises, by weight, at least 95% of DMDS, less than 500 ppm of methyl mercaptan, less than 100 ppm of dimethyl sulphide and up to 1% of at least one odor-masking agent.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: June 1, 2004
    Assignee: Elf Atochem S.A.
    Inventor: Georges Fremy
  • Patent number: 6727374
    Abstract: The present invention relates to asymmetrical siloxy compounds of the formula wherein R1, R2 and R3 are independently selected from the group consisting of alkoxy radicals having from 1 to 8 carbon atoms; and R4 is selected from the group consisting of substituted or unsubstituted alkylene groups having from 1 to 18 carbon atoms and arylene and alkyl substituted arylene groups having from 6 to 12 carbon atoms. The asymmetrical siloxy disulfide compounds are prepared from N-cyclohexylthiophthalimide and a mercaptoalkoxysilane.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: April 27, 2004
    Assignee: The Goodyear Tire & Rubber Company
    Inventors: Paul Harry Sandstrom, Lawson Gibson Wideman, Theodore Lamson Folk
  • Patent number: 6686506
    Abstract: The invention relates to a process for the preparation of organic disulfides by oxidation of mercaptans with sulfur dissolved in an organic disulfide using an amine as catalyst, where the mercaptans are used as “crude mercaptan stream” from a reaction of alcohols with hydrogen sulfide over a catalyst suitable for mercaptan synthesis. Furthermore, the invention relates to the use of the organic disulfides for the preparation of alkanesulfonic acids.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: February 3, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Werner Hesse, Hans-Josef Sterzel, Christian Tragut
  • Patent number: 6639110
    Abstract: A composition based on dimethyl disulphide (DMDS) with a masked smell according to the invention comprises, by weight, at least 95% of DMDS, less than 500 ppm of methyl mercaptan, less than 100 ppm of dimethyl sulphide and up to 1% of at least one odor-masking agent.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: October 28, 2003
    Assignee: Elf Atochem, S.A.
    Inventor: Georges Fremy
  • Patent number: 6639114
    Abstract: Ethylenically unsaturated compounds are hydroformylated in the presence of a hydroformylation catalyst comprising at least one complex of a metal of transition group VIII with at least one phosphorus-containing compound as ligand, where this compound contains two groups which contain P atoms and are bound to a molecular skeleton derived from bisphenol A.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: October 28, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Ahlers, Rocco Paciello, Dieter Vogt, Jarl Ivar van der Vlugt
  • Patent number: 6617392
    Abstract: The present invention provides the molding composition of siloxane, which is capable of extending mold lifetime where inhibitors alkene or acetylene polymerization are mixed in the molds composed of siloxane. The inhibitors can effectively inhibit the release of alkene or acetylene when a resin containing an alkene or acetylene is poured into the molds which extends lifetime of molds composed of siloxane. The inhibitors are compounds containing primarily sulfur, wherein sulfur is the most effective.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: September 9, 2003
    Inventor: Wen-Chen Yang
  • Patent number: 6600076
    Abstract: The present invention provides a novel class of water-soluble cleavable surfactants and methods for utilizing these surfactants.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: July 29, 2003
    Assignees: The Regents of the University of California, Wisconsin Alumni Research Foundation
    Inventors: Nicholas L. Abbott, Lana I. Jong
  • Patent number: 6596772
    Abstract: The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: July 22, 2003
    Assignee: Sugen, Inc.
    Inventors: Ping Huang, Chung Chen Wei, Peng Cho Tang, Chris Liang, John Ramphal, Bahija Jallal, John Biltz, Sharon Li, Matt Mattson, Gerald McMahon, Marcel Koenig
  • Publication number: 20030105362
    Abstract: A filtering means containing gelatinous and solid materials is cleaned without dismantling the filtering means by contacting the gelatinous material inside the filtering means with a solvent, thereby physically degrading the gelatinous material such that the degraded gelatinous material can pass through the filtering means.
    Type: Application
    Filed: May 9, 2002
    Publication date: June 5, 2003
    Applicant: Phillips Petroleum Company
    Inventor: Brooks D. Bennett
  • Patent number: 6555712
    Abstract: The present invention discloses a process for the preparation of a diorganotrisulfide said process by reacting an organic halide and elemental sulfur (&agr;-rhombic) using catalytic copper (II) halide and tin (II) halide in a mixture of organic solvents at 30-70° C.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: April 29, 2003
    Assignees: Indian Institute of Technology, Council of Scientific and Industrial Research
    Inventors: Pradipta Sinha, Sujit Roy