Reactant Contains -coo- Group Patents (Class 568/319)
  • Patent number: 9181167
    Abstract: A chemically-modified graphene includes a graphene layer and a plurality of functional groups that are grafted to the graphene layer and each of which is represented by —CO—R—COOH, wherein R is an optionally substituted C1-C5 alkylene group or an optionally substituted C1-C5 alkenylene group. A method for producing a chemically-modified grapheme includes subjecting a cyclic anhydride and graphite to a Friedel-Crafts reaction in the presence of a Lewis acid.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: November 10, 2015
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Shi-Liang Chen, Hsiao-Chien Chen, Rung-Ywan Tsai, Wu-Shiung Feng, Ming-Jer Jeng
  • Patent number: 9073839
    Abstract: The invention relates to a process for the preparation of a compound of formula (I) wherein the substituents are defined as in claim 1, which process comprises adding a compound of formula (II), wherein R1, R2 and R3 have the meanings as described under formula (I), in the presence of an inert organic solvent, to a mixture comprising an organic nitrite of formula (III) R4-O—N?O, wherein R4 is C1-C8alkyl, a compound of formula (IV), and an inert organic solvent.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: July 7, 2015
    Assignee: Syngenta Participations AG
    Inventors: Daniel Stierli, Harald Walter
  • Publication number: 20150141699
    Abstract: A process for pyrolyzing a coal feed is described. A coal feed is pyrolyzed into a coal tar stream and a coke stream in a pyrolysis zone. The coal tar stream is separated into at least a pitch stream comprising aromatic hydrocarbons. The pitch stream is reacted in a reaction zone to add at least one functional group to an aromatic ring of the aromatic hydrocarbons in the pitch stream. The functionalized pitch stream is recycled to the pyrolysis zone.
    Type: Application
    Filed: August 26, 2014
    Publication date: May 21, 2015
    Inventors: Paul T. Barger, Maureen L. Bricker, Joseph A. Kocal, Matthew Lippmann, Kurt M. Vanden Bussche
  • Patent number: 9035101
    Abstract: Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: May 19, 2015
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Gary David Annis
  • Publication number: 20150031919
    Abstract: The invention relates to a process for the preparation of a compound of formula (I) wherein the substituents are defined as in claim 1, which process comprises adding a compound of formula (II), wherein R1, R2 and R3 have the meanings as described under formula (I), in the presence of an inert organic solvent, to a mixture comprising an organic nitrite of formula (III) R4—O—N?O, wherein R4 is C1-C8alkyl, a compound of formula (IV), and an inert organic solvent.
    Type: Application
    Filed: February 28, 2012
    Publication date: January 29, 2015
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Daniel Stierli, Harald Walter
  • Patent number: 8816129
    Abstract: The present invention relates to chemical total synthesis methods of six novel protein tyrosine phosphatase-1B (PTP1B) inhibitors and application of the inhibitors in the preparation of medicaments for treating type 2 diabetes mellitus (T2DM). The PTP1B inhibitors use one or more of the six compounds represented by the structural formulae 1, 2, 3, 4, 5 and 6, as active components. The compounds can enhance the sensitivity of an insulin receptor by inhibiting the activity of PTP1B, thereby having a favorable therapeutic effect on insulin-resistant T2DM.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: August 26, 2014
    Assignee: Institute of Oceanology, Chinese Academy of Sciences
    Inventors: Dayong Shi, Shuju Guo, Xiao Fan, Weishen Lu, Yongchao Cui
  • Publication number: 20140235898
    Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.
    Type: Application
    Filed: March 14, 2014
    Publication date: August 21, 2014
    Applicant: UBE INDUSTRIES, LTD.
    Inventor: Teruo UMEMOTO
  • Publication number: 20140221584
    Abstract: A racemic complex of formula (I), wherein M is zirconium or hafnium; each X is a sigma ligand; L is a divalent bridge selected from —R?2C—, —R?2C—CR?2, —R?2Si—, —R?2Si—SiR?2—, —R?2Ge—, wherein each R? is independently a hydrogen atom, C1-20-hydrocarbyl, tri(C1-20-alkyl)silyl, C6-20-aryl, C7-20-arylalkyl or C7-20-alkylaryl; R2 and R2? are each independently a C1-20 hydrocarbyl radical optionally containing one or more heteroatoms from groups 14-16; R5? is a C1-20 hydrocarbyl group optionally containing one or more heteroatoms from groups 14-16 and optionally substituted by one or more halo atoms.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 7, 2014
    Applicant: BOREALIS AG
    Inventors: Norbert Hafner, Pascal Castro, Pavel Sergeevich Kulyabin, Vyatcheslav Izmer, Alexander Voskoboynikov, Luigi Resconi, Dmitry Kononovich, Ville Virkkunen, Dmitry Uborsky
  • Patent number: 8796335
    Abstract: The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: August 5, 2014
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Michael Hahn, Thomas Lampe, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Volkhart Min-Jian Li, Eva-Maria Becker, Friederike Stoll, Andreas Knorr, Elisabeth Woltering
  • Patent number: 8779207
    Abstract: The present subject matter relates to methods for the synthesis of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) and fullerene derivatives in a yield of at least 40%.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: July 15, 2014
    Assignee: Nano and Advanced Materials Institute Limited
    Inventors: Ka Ming Ng, Jianle Zhuang, Nai Wen Tseng, Yong Yu
  • Publication number: 20140155617
    Abstract: Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water.
    Type: Application
    Filed: September 30, 2013
    Publication date: June 5, 2014
    Applicant: E.I. du Pont de Nemours and Company
    Inventor: Gary David Annis
  • Patent number: 8710271
    Abstract: The present invention relates to a process for the preparation of a zeolitic material having a BEA framework structure comprising the steps of: (i) providing one or more zeolitic materials having a BEA framework structure, wherein the BEA framework structure comprises YO2 and X2O3, wherein Y is a tetravalent element, and X is a trivalent element; (ii) subjecting the one or more zeolitic materials provided in step (i) to a procedure for removing at least a portion of X, preferably tetrahedrally coordinated X, from the BEA framework structure; wherein the Y:X molar ratios of the one or more zeolitic materials provided in step (i) are respectively comprised in the range of from 1 to 50.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: April 29, 2014
    Assignees: BASF SE, Tokyo Institute of Technology
    Inventors: Bilge Yilmaz, Ulrich Müller, Faruk Özkirim, Takashi Tatsumi, Feng-Shou Xiao, Dirk de Vos, Xinhe Bao, Weiping Zhang, Hermann Gies, Hiroyuki Imai, Bart Tijsebaert
  • Patent number: 8604251
    Abstract: The invention pertains to novel oligofunctional photoinitiators of the formula (1) or (1A). R1 and R2 are methyl or together are —(CH2)5—; and n is 2 or 3, and the solvent in (1A) is water or an organic solvent; and their use in photopolymerizable compositions, in particular inks.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: December 10, 2013
    Assignee: BASF SE
    Inventors: Ulrich Berens, Jean-Luc Birbaum, Katia Studer
  • Patent number: 8546618
    Abstract: Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water.
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: October 1, 2013
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Gary David Annis
  • Patent number: 8487109
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional aryl-1-alkynes of the formula I.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: July 16, 2013
    Assignee: Sanofi
    Inventors: Omar Rkyek, Marc Nazare, Andreas Lindenschmidt, Matthias Urmann, Nis Halland, Jorge Alonso
  • Patent number: 8476510
    Abstract: The present invention generally relates to compositions comprising and methods for forming functionalized carbon-based nanostructures.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: July 2, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, William R. Collins, Wiktor Lewandowski, Ezequiel Schmois, Stefanie Sydlik, Joseph Walish, John B. Goods
  • Publication number: 20130131182
    Abstract: The present invention relates to chemical total synthesis methods of six novel protein tyrosine phosphatase-1B (PTP1B) inhibitors and application of the inhibitors in the preparation of medicaments for treating type 2 diabetes mellitus (T2DM). The PTP1B inhibitors use one or more of the six compounds represented by the structural formulae 1, 2, 3, 4, 5 and 6, as active components. The compounds can enhance the sensitivity of an insulin receptor by inhibiting the activity of PTP1B, thereby having a favorable therapeutic effect on insulin-resistant T2DM.
    Type: Application
    Filed: July 7, 2011
    Publication date: May 23, 2013
    Applicant: INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Dayong Shi, Shuju Guo, Xiao Fan, Weishen Lu, Yongchao Cui
  • Patent number: 8350090
    Abstract: The present invention provides novel processes of preparing racemic and optically active cyclopentenones of Formula I: The invention also provides novel cyclopentenones of formula I in racemic or optically active form.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: January 8, 2013
    Assignee: Chirogate International Inc.
    Inventors: Shih-Yi Wei, Wan-Chun Chang, Yu-Chih Yeh
  • Publication number: 20120316340
    Abstract: The use of metal-accumulating plants for implementing chemical reactions.
    Type: Application
    Filed: November 18, 2010
    Publication date: December 13, 2012
    Applicants: UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Claude Grison, Jose Escarre
  • Publication number: 20120259141
    Abstract: The present invention relates to a process for the preparation of a zeolitic material having a BEA framework structure comprising the steps of: (i) providing one or more zeolitic materials having a BEA framework structure, wherein the BEA framework structure comprises YO2 and X2O3, wherein Y is a tetravalent element, and X is a trivalent element; (ii) subjecting the one or more zeolitic materials provided in step (i) to a procedure for removing at least a portion of X, preferably tetrahedrally coordinated X, from the BEA framework structure; wherein the Y:X molar ratios of the one or more zeolitic materials provided in step (i) are respectively comprised in the range of from 1 to 50.
    Type: Application
    Filed: April 3, 2012
    Publication date: October 11, 2012
    Applicants: Tokyo Institute of Technology, BASF SE
    Inventors: Bilge Yilmaz, Ulrich Müller, Faruk Özkirim, Takashi Tatsumi, Feng-Shou Xiao, Dirk de Vos, Xinhe Bao, Weiping Zhang, Hermann Gies, Hiroyuki Imai, Bart Tijsebaert
  • Publication number: 20120238781
    Abstract: A modified dimethylnaphthalene formaldehyde resin obtained by modifying a polyfunctional dimethylnaphthalene formaldehyde resin having a constituent unit represented by the following general formula [1] in a molecule thereof with at least one member selected from the group consisting of a phenol represented by the following general formula [2], a naphthol represented by the following general formula [3] and a naphthol represented by the following general formula [4] provided that at least any of the naphthol represented by the general formula [3] or the naphthol represented by the general formula [4] must be included.
    Type: Application
    Filed: March 19, 2012
    Publication date: September 20, 2012
    Applicant: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Seiji Kita, Masashi Ogiwara, Mitsuharu Kitamura, Dai Oguro, Gou Higashihara
  • Publication number: 20120202066
    Abstract: Disclosed are improved processes for preparing prasugrel compound of formula-(1), its intermediates and pharmaceutically acceptable salts.
    Type: Application
    Filed: October 7, 2010
    Publication date: August 9, 2012
    Inventors: Manne Satyanarayana Reddy, Srinivasan Thirumalai Rajan, Sajja Eswaraiah, Karamala Rama Subba Reddy, Bairy Kondal Reddy, Ghojala Venkat Reddy
  • Publication number: 20120190881
    Abstract: A compound of Formula (4), wherein each X is independently fluorine or chlorine; n is 1 or 2; R1 is C3-C8 alkyl, phenyl or benzyl; and R2 is C1-C6 alkyl; and its production and use.
    Type: Application
    Filed: July 22, 2010
    Publication date: July 26, 2012
    Inventor: Peter Hans Ermann
  • Publication number: 20120116094
    Abstract: The present invention generally relates to compositions comprising and methods for forming functionalized carbon-based nanostructures.
    Type: Application
    Filed: November 3, 2011
    Publication date: May 10, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, William R. Collins, Wiktor Lewandowski, Ezequiel Schmois, Stefanie Sydlik, Joseph Walish, John B. Goods
  • Patent number: 8163962
    Abstract: [Problems to be Solved] The present invention aims to provide a method for efficiently producing a high-purity alkoxyindanone derivative while maintaining an industrially superior volumetric efficiency. [Solution] Provided is a method for producing an alkoxyindanone derivative represented by a general formula in FIG. 2 (wherein R represents an alkoxy group containing 1 to 6 carbon atoms and n represents an integer of 1 to 4), comprising reacting an alkoxyphenylpropionic acid derivative represented by a general formula in FIG. 1 (wherein R and n are as defined above) with a condensing agent, adding an organic solvent to the resulting reaction mixture, and subsequently decomposing the condensing agent with an aqueous alkaline solution.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: April 24, 2012
    Assignee: DNP Fine Chemicals Fukushima Co., Ltd.
    Inventors: Tetsuya Ooyama, Takashi Onozawa, Shin Ikeda, Yoshinobu Suzuki
  • Publication number: 20110009638
    Abstract: Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water.
    Type: Application
    Filed: April 8, 2009
    Publication date: January 13, 2011
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventor: Gary David Annis
  • Publication number: 20100261910
    Abstract: The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional aryl-1-alkynes of the formula I.
    Type: Application
    Filed: December 23, 2009
    Publication date: October 14, 2010
    Applicant: sanofi-aventis
    Inventors: Omar RKYEK, Marc NAZARE, Andreas LINDENSCHMIDT, Matthias URMANN, Nis HALLAND, Jorge ALONSO
  • Publication number: 20100261935
    Abstract: [Problems to be Solved] The present invention aims to provide a method for efficiently producing a high-purity alkoxyindanone derivative while maintaining an industrially superior volumetric efficiency. [Solution] Provided is a method for producing an alkoxyindanone derivative represented by a general formula in FIG. 2 (wherein R represents an alkoxy group containing 1 to 6 carbon atoms and n represents an integer of 1 to 4), comprising reacting an alkoxyphenylpropionic acid derivative represented by a general formula in FIG. 1 (wherein R and n are as defined above) with a condensing agent, adding an organic solvent to the resulting reaction mixture, and subsequently decomposing the condensing agent with an aqueous alkaline solution.
    Type: Application
    Filed: November 14, 2008
    Publication date: October 14, 2010
    Applicant: DNP FINE CHEMICALS FUKUSHIMA CO., LTD.
    Inventors: Tetsuya Ooyama, Takashi Onozawa, Shin Ikeda, Yoshinobu Suzuki
  • Publication number: 20100249411
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Inventors: Wenxue Wu, Hongbiao Liao, David J.S. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Publication number: 20100234643
    Abstract: The present invention aims to provide reduced coenzyme Q10, which is useful as food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, and a production method of reduced coenzyme Q10. The present invention provides a production method of reduced coenzyme Q10, which includes reducing oxidized coenzyme Q10 with ascorbic acid or its analogue(s) as a reducing agent in a water-containing organic solvent at not more than pH 5. Using the method, the reaction time can be drastically shortened even without adding a basic substance and the like, and unpreferable side reactions can be minimized. Therefore, reduced coenzyme Q10 with high quality can be produced.
    Type: Application
    Filed: October 29, 2008
    Publication date: September 16, 2010
    Applicant: KANEKA CORPORATION
    Inventors: Takahiro Ueda, Shiro Kitamura
  • Publication number: 20100217047
    Abstract: A process for synthesizing 3,4?dihydroxybenzophenone by reacting meta-hydroxybenzoic acid and phenol in the presence of a Lewis acid, and a protonic acid. Upon completion of the reaction the Lewis and protonic acids are removed and then the reaction product of 3,4?dihydroxybenzophenone is contacted with water (at temperature not greater than 10° C.) and ammonium hydroxide followed by filtration.
    Type: Application
    Filed: February 26, 2009
    Publication date: August 26, 2010
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: KIU-SEUNG LEE, MICHAEL FRANCIS VINCENT
  • Publication number: 20100217046
    Abstract: A process for producing 3,4?diacetoxybenzophenone by first synthesizing 3,4?dihydroxybenzophenone by reacting meta-hydroxybenzoic acid and phenol in the presence of a Lewis acid, and a protonic acid followed by reacting the 3,4?dihydroxybenzophenone with an acetylating agent in the presence of an inorganic acid and activated carbon.
    Type: Application
    Filed: February 26, 2009
    Publication date: August 26, 2010
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Kiu-Seung LEE, Michael Francis VINCENT
  • Patent number: 7772441
    Abstract: A process for synthesizing 3,4?dihydroxybenzophenone by reacting meta-hydroxybenzoic acid and phenol in the presence of a Lewis acid, and a protonic acid. Upon completion of the reaction the Lewis and protonic acids are removed and then the reaction product of 3,4?dihydroxybenzophenone is contacted with water (at temperature not greater than 10° C.) and ammonium hydroxide followed by filtration.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: August 10, 2010
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Kiu-Seung Lee, Michael Francis Vincent
  • Patent number: 7732642
    Abstract: Functionalized detonation nanodiamond particulates of the formula: wherein Ar is selected from the group consisting of: wherein R is selected from the group consisting of H, H3C—(CH2)n— and wherein n has a value of 0-10. Also provided is a process for functionalizing detonation nanodiamonds particulates.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: June 8, 2010
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Loon-Seng Tan, David H. Wang
  • Publication number: 20100121082
    Abstract: The invention relates to a process for preparing 2,4-dihydroxyphenyl 4-methoxybenzyl ketones of the formula (I) by Friedel-Crafts acylation in hydrogen fluoride (HF). 2,4-Dihydroxyphenyl 4-methoxybenzyl ketones of the formula (I) in which R1 and R2 are each hydrogen, chlorine, fluorine, bromine, iodine, CF3, methyl, optionally substituted alkoxy, —OCF3, —C(CH3)3, —CH2(CH3)2, —CH(CH3)2, R3 is hydrogen, Cl, F, Br, optionally substituted alkyl, optionally substituted alkoxy, —C(CH3)3, and X is hydroxyl, F, Cl, Br, optionally substituted alkoxy, are obtained in high yield and high purity by reacting phenylacetic acid derivatives of the formula (II) with phenols of the formula (III) in liquid hydrogen fluoride (HF).
    Type: Application
    Filed: February 16, 2008
    Publication date: May 13, 2010
    Inventors: Sergii Pazenok, Norbert Lui
  • Publication number: 20100048727
    Abstract: Novel perfluoroketone compounds of formula [I] and [Ia] are described. Also described are uses thereof, such as for inhibition of phospholipase A2 activity. Therapeutic uses thereof are also described, such as for the treatment of neural conditions and/or inflammatory conditions, such as demyelinating (e.g., multiple sclerosis) and neural injury (e.g., spinal cord injury).
    Type: Application
    Filed: April 4, 2008
    Publication date: February 25, 2010
    Inventors: Samuel David, Athena Kalyvas, Ruben Lopez-Vales, George Kokotos, Violetta Constantinou-Kokotou, Constantinos Baskakis, Christoforos G. Kokotos, Edward A. Dennis, Daren Stephens
  • Publication number: 20100010235
    Abstract: In accordance with aspects of the invention methods of using rhodium hydroquinone catalysts for the conjugate addition of boronic acids are disclosed.
    Type: Application
    Filed: June 19, 2009
    Publication date: January 14, 2010
    Inventors: William C. Trenkle, Julia L. Barkin, Seung Uk Son, Dwight A. Sweigart, Marcus D. Faust, JR.
  • Publication number: 20090317753
    Abstract: A method for producing highly purified fused aromatic ring compounds with high yield by a simpler method. A method for producing a fused aromatic ring compound comprising irradiating the bicyclo compound containing at least one bicyclo ring represented by formula (1) in a molecule with light to detach a leaving group X from a residual part to form an aromatic ring: wherein R1 and R3 each denotes a group to form an aromatic ring or a heteroaromatic ring which may be substituted, together with a group to which each thereof is bonded; R2 and R4 each denotes a hydrogen atom, an alkyl group, an alkoxy group, an ester group or a phenyl group; and X is a leaving group, which denotes a carbonyl group or —N?.
    Type: Application
    Filed: September 1, 2009
    Publication date: December 24, 2009
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Hidemitsu Uno, Noboru Ono
  • Patent number: 7473807
    Abstract: The present invention relates to new crystalline molecular sieve SSZ-74 prepared using a hexamethylene-1,6-bis-(N-methyl-N pyrrolidinium) dication as a structure-directing agent, methods for synthesizing SSZ-74 and processes employing SSZ-74 in a catalyst.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: January 6, 2009
    Assignee: Chevron USA, Inc.
    Inventors: Stacey I. Zones, Allen W. Burton, Jr.
  • Patent number: 7462650
    Abstract: The Invention relates to novel ketones of formulae (I) and (II) wherein R1, R2, R3 and R4 are, for example, C1-C8alkyl, R5 is, for example, hydrogen, A is CI, Br, -0-R7, —NR8R9 or —S—R16, A? is —O—, —NH— or —NR8—, X and Y are each independently of the other —O—R10 or —N(R11)(R12), n is an integer from 1 to 10, R6 is, for example, an n-valent radical of linear or branched C2-C20alkyl the carbon chain of which may be interrupted by cyclohexanediyl, phenylene, —CH(OH)—, —C(C2H5)(CH2—CH2—OH)—, —C(CH3)(CH2—CH2—OH)—, —C(CH2—CH2—OH)2—, —N(CH3)—, —N(C2H5)—, —N(CH2—CH2—OH)—, —CO—O—, —O—CO—, —P(CH2—CH2—OH)—, —P(O)(CH2—CH2—OH)—, -0-P(O—CH2—CH2—OH)—O—, -0-P(O)(0-CH2—CH2—OH)—O—, —O-cyclohexanediyl-C(CH3)2-Cyclohexanediyl-O—, —O-phenylene-C(CH3)2-phenylene-O—, —O-phenylene-CH2-phenylene-O—, —Si(CH3)2—, -0-Si(CH3)2—O—, —O—Si(CH3)(0-CH3)—O—, —Si(CH3)(R17)—O—Si(CH3)(R18)—, 5-(2-hydroxyethyl)-[1,3,5]triazinane-2,4,6-trione-1,3-diyl and/or by from one to nine oxygen atoms.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: December 9, 2008
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Reinhard H. Sommerlade, Rinaldo Hüsler, Stephan Ilg, André Fuchs, Souâd Boulmaâz, Jean-Luc Birbaum
  • Publication number: 20080200731
    Abstract: Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about ?5 to about +100° C. Some of the cinnamic acids and cinnamic acid derivatives obtainable in this way are new. Cinnamic acids and cinnamic acid derivatives which can be prepared according to the invention can be used for the preparation of indanones which are precursors for agro- and pharmaceutical chemicals and for substances having liquid-crystalline properties.
    Type: Application
    Filed: April 22, 2008
    Publication date: August 21, 2008
    Inventors: Walter Lange, Joachim Komoschinski, Markus Eckert, Michael Dockner
  • Patent number: 7405328
    Abstract: In a method or producing haloalkenone ethers by addition of a carboxylic acid halide to a vinyl ether and subsequent elimination of hydrogen halide, the improvement comprising carrying out the reaction in the absence of a base and/or in the presence of a stabilizer for the resulting alkenone, whereby higher yields of the desired alkenone product can be obtained.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: July 29, 2008
    Assignee: Solvay Fluor GmbH
    Inventors: Eckhard Hausmann, Oalf Boese, Johannes Eicher
  • Patent number: 7393981
    Abstract: A catalytic process for producing ketones and particularly methyl-benzyl-ketone is provided. A catalyst comprising thorium oxide and a second metal oxide, preferably MnO, is formed on a substrate, preferably pumice. Phenylacetic acid and acetic acid are reacted in the presence of the catalyst to form methyl-benzyl-ketone.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: July 1, 2008
    Assignee: Property Development Corporation International, Ltd, Inc.
    Inventors: Alimamed Latif Shabanov, Elmira Mamedem Ramazanova
  • Patent number: 7381849
    Abstract: This invention relates to the compositions and processes for preparing 2,3,3?,4?-tetramethylbenzophenone and asymmetrical dianhydrides such as 2,3,3?,4? benzophenone dianhydride (a-BTDA), and 3,4?-(hexafluoroisopropylidene)diphthalic anhydride (a-6FDA). a-BTDA is prepared by Suzuki coupling with catalysts from a mixed anhydride of 3,4-dimethylbenzoic acid and 2,3-dimethylbenzoic acid with a respective 2,3-dimethylphenylboronic acid and 3,4-dimethyl phenylboronic acid to form 2,3,3?,4?-tetramethylbenzophenone which is oxidized to 2,3,3?,4?-benzophenonetetracarboxylic acid followed by cyclodehydration to obtain a-BTDA. The a-6FDA was prepared by nucleophilic trifluoromethylation of 2,3,3?,4?-tetramethylbenzophenone with trifluoromethyltrimethylsilane to form 3,4?-(trifluoromethylmethanol) bis(o-xylene) which is converted to 3,4?-(hexafluoroisopropylidene-bis(o-xylene). The 3,4?-(hexafluoroisopropylidene)-bis(o-xylene) is oxidized to the corresponding tetraacid followed by cyclodehydration to yield a-6FDA.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: June 3, 2008
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Chun-Hua Chuang
  • Patent number: 7321044
    Abstract: The invention relates to intermediate products and a new process for the production of benzocycloheptene C. The process for the production of its new intermediate products according to the invention starts from economical starting materials, provides the intermediate stages in high yields and high purity, without chromatographic purification steps, and allows production on an industrial scale.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: January 22, 2008
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Wolfgang Beckmann, Jens Geisler, Holger Kirstein, Ulrich Niedballa, Eckhard Ottow, Sigmar Radau, Claudia Schulz, Thomas Wessa
  • Patent number: 7307192
    Abstract: The invention relates to a process for the preparation of a crystalline isomeric mixture of compounds of formulae (I) and (II) which process comprises the following steps: a) the slow addition of aluminium chloride, in portions, to a solution comprising 1,1,3-trimethyl-3-phenylindan and isobutyric acid halide in a suitable solvent at a reaction temperature of from ?20° C. to 20° C., an isomeric mixture consisting of compounds of formulae (Ia) and (IIa) being obtained; b) enol chlorination of compounds (Ia) and (IIa), an isomeric mixture consisting of compounds of formulae (Ib) and (IIb) being obtained; c) hydrolysis of the chlorinated isomeric mixture from step b). The invention relates also to the preparation of the individual compounds (I) and (II).
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: December 11, 2007
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Rinaldo Hüsler, Thomas Horni
  • Patent number: 7250510
    Abstract: The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: July 31, 2007
    Assignee: Total Synthesis, Ltd.
    Inventors: Michael G. Organ, Christopher J. O'Brien, Assam (Eric) B. Kantchev
  • Patent number: 7211705
    Abstract: Phase-selective soluble polymer supports for catalysts are described. The catalysts utilize polystyrene copolymers having enhanced solubility in nonpolar solvents. Other catalysts of the invention utilize polyisobutylene supports. Methods of catalyzing chemical reactions using latent biphasic solvents are also disclosed.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: May 1, 2007
    Assignee: The Texas A&M University System
    Inventors: David E. Bergbreiter, Chunmei Li, Jacqueline O. Besinaiz, Jun Li, Shayna D. Sung
  • Patent number: 7166749
    Abstract: A biotransformation process for preparing chiral aromatic-hydroxy ketones in high yields is described, using 2-hydroxy-3-oxoacid synthase, such as AHAS or TSAS. Optionally substituted arylaldehydes and -oxoacids react in this process to provide pure enantiomers, useful as synthons in the production of various drugs, an example being (R)-phenylacetyl carbinol.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: January 23, 2007
    Assignee: Ben-Gurion University of the Negev
    Inventors: David M. Chipman, Ze'ev Barak, Stanislav Engel, Maria Vyazmensky
  • Patent number: 7129367
    Abstract: Palladum-phosphine complexes obtained by reacting a 5 compound of formula (1) below with a palladium compound: F(I) (wherein R1 is a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R2 and R3 are each, the same or different, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R4 and R5 are each, the same or different, a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R6, R7, R8 and R9 are each, the same or different, an alkyl group, a cycloalkyl group, a phenyl group which may be substituted, an alkoxyl group, a dialkylamino group, a halogen atom, a phenyl group, a benzyl group, a naphthyl group or a halogenated alkyl group; R6 and R7, R8 and R9 may be combined to form, each, a fused ring, a trimethylene group, a tetramethylene group or a 20 methylenedioxy group; p, q, r and s are each an integer of 0 to 5; and p+q, and r+s are each in the range of 0 to 5.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: October 31, 2006
    Assignee: Takasago International Corporation
    Inventors: Ken Suzuki, Yoji Hori