Oxy Containing Reactant Patents (Class 568/322)
  • Patent number: 10123966
    Abstract: Provided is a method for increasing hair shaft diameter, the method including applying a hair care composition to a region of the hair, wherein the hair care composition includes from about 0.01% to about 10% of hops, wherein the hops is first extracted in glycerin; and from about 0.1% to about 10% of a rheology modifier.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: November 13, 2018
    Assignee: The Procter and Gamble Company
    Inventors: Goher Mahmud, Mary Jane Combs
  • Patent number: 9156758
    Abstract: The present invention provides a process for producing a compound comprising a perfluorinated alkyl group moiety from a carbonyl compound. Typically, the process includes contacting a carbonyl compound with a silane compound in the presence of a fluorohydrogenate ionic liquid under conditions sufficient to produce a compound comprising a perfluorinated alkyl group. The silane compound includes a perfluoroalkyl group.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: October 13, 2015
    Assignee: CoorsTek Fluorochemicals, Inc.
    Inventor: Rajendra P. Singh
  • Publication number: 20150126763
    Abstract: The description provides processes for the regio and stereospecific synthesis of polyprenylatedquinone derivatives, such as Vitamin K1, K2 and Ubiquinone, exploiting dithioacetals, especially 1,3-dithiane, mediated Umpolung chemistry which works along a new concept “Inhibiting resonance delocalization (IRD)” to overcome isomerization generated due to delocalization of allyliccarbanion on the ?-electron cloud of an allylic systems by the conventional synthesis.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 7, 2015
    Inventors: Dilip S. Mehta, Priya Mohan, Mayank Shastri, Ted Reid
  • Publication number: 20150086473
    Abstract: Objects of the present invention are to provide a novel dehydrogenation reaction catalyst, to provide a method that can produce a ketone, an aldehyde, and a carboxylic acid with high efficiency from an alcohol, and to provide a method for efficiently producing hydrogen from an alcohol, formic acid, or a formate, and they are accomplished by a catalyst containing an organometallic compound of Formula (1).
    Type: Application
    Filed: February 22, 2013
    Publication date: March 26, 2015
    Applicant: Kanto Kagaku Kabushiki Kaisha
    Inventors: Ryohei Yamaguchi, Ken-ichi Fujita
  • Patent number: 8981159
    Abstract: The invention relates to a method for the oxidation of a primary or secondary alcohol, preferably to form an aldehyde or ketone, comprising the following steps: a) providing a catalyst composition comprising at least one compound containing a nitroxyl radical, at least one NO source, at least one carbon or mineral acid or an anhydride of a carbon or mineral acid; b) producing a reaction mixture by adding at least one primary or secondary alcohol and a gas comprising oxygen and optionally one or more than one solvent to the catalyst composition from step a) or step e); c) incubating the reaction mixture from step b) at a temperature of between 0 and 100° C. or at the boiling point of the solvent; d) simultaneously with or subsequent to step c): crystallizing the reaction product; and e) recovering the catalyst composition by removing the crystallized reaction product from the reaction mixture obtained in step d).
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: March 17, 2015
    Assignee: Evonik Degussa GmbH
    Inventors: Florian Klasovsky, Thomas Haas, Thomas Tacke, Jan Christoph Pfeffer, Michael Rimbach, Michael Volland, Michiel Janssen, Roger Sheldon, Juergen Haberland
  • Patent number: 8946483
    Abstract: The present invention relates to a method of obtaining radiopharmaceutical precursors, and in particular precursors to protected amino acid derivatives, which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures, such as positron emission tomography (PET).
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 3, 2015
    Assignee: GE Healthcare Limited
    Inventors: Radha Achhanath, Srinath Balaji, Asfal Mohammed Kadavilpparampu Mohamed, Sondre Nilsen, Steven Michael Fairway
  • Publication number: 20140371490
    Abstract: In a process for producing phenol, a mixture of cyclohexylbenzene with from 10 to 90 wt % of a solvent is contacted with oxygen in the presence of a catalyst and under conditions effective to oxidize at least a portion of the cyclohexylbenzene to cyclohexylbenzene hydroperoxide. The catalyst comprises a cyclic imide having an imide group of formula (I): wherein X represents an oxygen atom, a hydroxyl group, or an acyloxy group. At least a portion of the oxygen is dissolved in the mixture and the liquid phase molar ratio of cyclohexylbenzene to oxygen dissolved in the mixture is less than or equal to 20,000:1.
    Type: Application
    Filed: December 3, 2012
    Publication date: December 18, 2014
    Inventors: Bryan A. Patel, Jihad M. Dakka
  • Publication number: 20140371489
    Abstract: In a process for producing phenol, a feed comprising cyclohexylbenzene hydroperoxide is contacted with a cleavage catalyst comprising a fluorinated acidic resin under cleavage conditions effective to convert at least a portion of the cyclohexylbenzene hydroperoxide into phenol and cyclohexanone.
    Type: Application
    Filed: August 10, 2012
    Publication date: December 18, 2014
    Inventors: Kun Wang, Roberto Garcia, Francisco M. Benitez
  • Publication number: 20140350258
    Abstract: Novel alpha-hydrogen substituted nitroxyl compounds and their corresponding oxidized (oxoammonium cations) and reduced (hydroxylamine) forms, and the use of such compounds, inter alia, for oxidation of primary and secondary alcohols to aldehydes and ketones, respectively; resolution of racemic alcohols; desymmetrization of meso-alcohol; as radicals and spin trapping reagents; and as polymerization agents. Processes for preparing the novel nitroxyl/oxoammonium/hydroxylamine compounds from the corresponding amines, and certain novel amine derivatives and their uses. The compounds and amine precursors are useful as ligands for transition metals and as organocatalysts in e.g., aldol reactions.
    Type: Application
    Filed: August 6, 2014
    Publication date: November 27, 2014
    Inventors: Alex M. Szpilman, Michal Amar
  • Patent number: 8871981
    Abstract: A method for oxidizing an alcohol, wherein oxidation is performed in the presence of a compound represented by the following formula (I) and a bulk oxidant, which enables efficient oxidation of secondary alcohols as well as primary alcohols, and can attain high reaction efficiency even when air is used as a bulk oxidant.
    Type: Grant
    Filed: May 30, 2011
    Date of Patent: October 28, 2014
    Assignee: Tohoku University
    Inventors: Yoshiharu Iwabuchi, Masaki Hayashi
  • Publication number: 20140296544
    Abstract: The present invention provides a method for converting an aromatic hydrocarbon to a phenol by providing an aromatic hydrocarbon comprising one or more aromatic C—H bonds and one or more activated C—H bonds in a solvent; adding a phthaloyl peroxide to the solvent; converting the phthaloyl peroxide to a di-radical; contacting the di-radical with the one or more aromatic C—H bonds; oxidizing selectively one of the one or more aromatic C—H bonds in preference to the one or more activated C—H bonds; adding a hydroxyl group to the one of the one or more aromatic C—H bonds to form one or more phenols; and purifying the one or more phenols.
    Type: Application
    Filed: August 14, 2013
    Publication date: October 2, 2014
    Inventors: Dionicio Siegel, Andrew M. Camelio, Anders Eliasen, Trevor C. Johnson, Abram Axelrod, Changxia Yuan
  • Patent number: 8828908
    Abstract: Bicyclic dione compounds of formula (I), and derivatives thereof, which are suitable for use as herbicides.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: September 9, 2014
    Assignee: Syngenta Limited
    Inventors: Christopher John Mathews, Matthew Brian Hotson, Alan John Dowling, James Nicholas Scutt, Mangala Govenkar, Lee Challinor
  • Publication number: 20140121187
    Abstract: Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
    Type: Application
    Filed: June 18, 2012
    Publication date: May 1, 2014
    Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Young Sik Jung, Chong Kgo Lee, Ihl Young Choi, Hae Soo Kim, Pil Ho Kim, Soo Bong Han, Johan Neyts, Hendrik Jan Thibaut
  • Publication number: 20140100371
    Abstract: A process for preparing azomethines of the general formula (V) where R is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted alkyl radical or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, and R1 is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, R2 is hydrogen or an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted alkyl radical or an optionally substituted cycloalkyl radical N or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms by reacting alpha-oxo carboxylates of the general formula (I) where n is a number in the range from 1 to 6, M(n+) is a cation, with aryl bromides of the general formula (IV) and amines of the general formula (II) via the alpha-iminocarboxylate intermediate of the general formula (III), in the p
    Type: Application
    Filed: November 18, 2011
    Publication date: April 10, 2014
    Applicant: Saltigo GmbH
    Inventors: Alain Cotte, Matthias Cotta, Felix Rudolph, Bingrui Song, Lukas Goossen
  • Publication number: 20140100354
    Abstract: Novel peptoids are disclosed that have a formula represented by the following formulae Ia and Ib: wherein X, Y, R, and n are as described herein. The peptoids demonstrate catalytic activity and are useful in substrate-selective catalytic transformations, including asymmetric catalytic transformations.
    Type: Application
    Filed: October 4, 2012
    Publication date: April 10, 2014
    Inventors: Kent KIRSHENBAUM, Galia Maayan, Michael Ward
  • Patent number: 8569526
    Abstract: The invention relates to a method for carrying out an oxidation reaction for producing a product by heating a reaction medium containing a reactant and oxygen or an oxygen carrier in a reactor, wherein the reaction medium is brought into contact with a solid heating medium which may be heated by electromagnetic induction, which is surrounded by the reaction medium. The heating medium is heated by electromagnetic induction using an inductor, wherein an oxidation reaction is carried out on the first reactant to give a product and the product is separated from the heating medium. The inductor preferably generates an alternating field with a frequency in the range 1 to 100 kHz, preferably in the range 10 to 80 kHz and in particular up to 50 kHz.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: October 29, 2013
    Assignee: Henkel AG & Co. KGaA
    Inventors: Carsten Friese, Andreas Kirschning, Sascha Volkan Ceylan
  • Publication number: 20130267712
    Abstract: A method of preparing an aryl carbonyl or aryl thiocarbonyl compound, comprises reacting an N-(nitroaryl)-amide or N-(nitroaryl)-thioamide with an aromatic ring, with a superacid catalyst, to produce the aryl carbonyl or aryl thiocarbonyl compound. The superacid is present in an amount of at most 8 equivalents in proportion to the N-(nitroaryl)-amide or N-(nitroaryl)-thioamide. A method of preparing aryl amide or aryl thioamide, comprises reacting an N-(nitroaryl)-carbamide or N-(nitroaryl)-thiocarbamide with an aromatic ring, with a superacid catalyst, to produce the aryl amide or aryl thioamide.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 10, 2013
    Applicant: Board of Trustees of Northern Illinois University
    Inventors: Douglas A. Klumpp, Erum K. Raja
  • Publication number: 20130217674
    Abstract: Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and A are as defined herein are disclosed. Such compounds have enhanced water solubility and have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Enantioselective methods for preparation of compounds of structure (I), compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluents and methods of SHIP1 modulation by administration of such compounds to an animal in need thereof are also disclosed.
    Type: Application
    Filed: August 22, 2011
    Publication date: August 22, 2013
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Xiaoxia Wang, Labros George Meimetis, Matthew Bruce Nodwell, Raymond Andersen
  • Publication number: 20130190501
    Abstract: The present invention relates to processes for the preparation of 4?-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3?-methoxyacetophenone and intermediates thereof. The present invention also provides a process for purifying 4?-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3?-methoxyacetophenone to obtain the purity greater than about 98.0 area % to about 99.0 area % as measured by HPLC, preferably greater than about 99.0 area % to about 99.5 area %, more preferably greater about 99.5 area % to about 99.9 area %. individual impurities lower than about 0.15 area %, preferably lower than about 0.1% and total impurities lower than about 0.5 area % by HPLC.
    Type: Application
    Filed: July 18, 2011
    Publication date: July 25, 2013
    Applicant: SYMED LABS LIMITED
    Inventors: Dodda Mohan Rao, Pingili Krishna Reddy, Buthukuri Venkat Reddy
  • Publication number: 20130172543
    Abstract: A method for oxidizing an alcohol, wherein oxidation is performed in the presence of a compound represented by the following formula (I) and a bulk oxidant, which enables efficient oxidation of secondary alcohols as well as primary alcohols, and can attain high reaction efficiency even when air is used as a bulk oxidant.
    Type: Application
    Filed: May 30, 2011
    Publication date: July 4, 2013
    Applicant: TOHOKU UNIVERSITY
    Inventors: Yoshiharu Iwabuchi, Masaki Hayashi
  • Publication number: 20130123514
    Abstract: The disclosure relates to catalytically active carbocatalysts, e.g., a graphene oxide or graphite oxide catalyst suitable for use in a variety of chemical transformations. In one embodiment, it relates to a method of catalyzing a chemical reaction of an organic molecule by reacting the organic molecule in the presence of a sufficient amount of graphene oxide or graphite oxide for a time and at a temperature sufficient to allow catalysis of a chemical reaction. According to other embodiments, the reaction may be an oxidation reaction, a hydration reaction, a dehydrogenation reaction, a condensation reaction, or a polymerization reaction. Some reactions may include auto-tandem reactions. The disclosure further provides reaction mixtures containing an organic molecule and graphene oxide or graphite oxide in an amount sufficient to catalyze a reaction of the organic molecule.
    Type: Application
    Filed: May 27, 2011
    Publication date: May 16, 2013
    Applicant: GRAPHEA, INC.
    Inventors: Christopher W. Bielawski, Daniel R. Dreyer, Hong-Peng Jia
  • Publication number: 20130108540
    Abstract: Disclosed is a method for producing graphene functionalized at its edge positions of graphite. Organic material having one or more functional groups is reacted with graphite in reaction medium comprising methanesulfonic acid and phosphorus pentoxide, or in reaction medium comprising trifluoromethanesulfonic acid, to produce graphene having organic material fuctionalized at edges. And then, high purity and large scaled graphene and film can be obtained by dispersing, centrifugal separating the functionalized graphene in a solvent and reducing, in particular heat treating the graphene. According to the present invention graphene can be produced inexpensively in a large amount with a minimum loss of graphite.
    Type: Application
    Filed: February 24, 2012
    Publication date: May 2, 2013
    Inventors: Jong Beom Baek, Eun Kyoung Choi, In Yup Jeon, Seo Yoon Bae
  • Patent number: 8394993
    Abstract: The invention relates to a process for the preparation of cyclopropyl benzyl ketone compounds of formula (II) wherein R1 represents fluorine or chlorine atom or C1-4 alkoxy group, by the reaction of a Grignard reagent, obtained from the reaction of compound of formula (V), wherein X represents chlorine or fluorine atom, with the compound of formula (IV), wherein R2 represents C1-4 alkyl group, having a straight or branched chain. The process can be applied preferably on industrial scale. Compound of formula (II), wherein R represents a fluorine atom in position 2 is an intermediate of the preparation process of prasugrel, which is a platelet inhibitor used in the therapy.
    Type: Grant
    Filed: November 27, 2008
    Date of Patent: March 12, 2013
    Assignee: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Tibor Mezei, Gyula Lukács, Enikó Molnár, József Barkóczy, Balázs Volk, Márta Porcs-Makkay, János Szulágyi, Mária Vajjon
  • Publication number: 20130058879
    Abstract: The invention relates to the use of at least one specific triazine or melamine and/or salt thereof as accelerator for a photoinduced reaction of 3-(4-tert-butylphenyl)-3-hydroxy-1-(4-methoxyphenyl)-propan-1-one, 1-(4-tert-butylphenyl)-3-hydroxy-3-(4-methoxyphenyl)-propan-1-one or a mixture of these compounds to give avobenzone. The invention furthermore relates to a composition comprising at least one specific triazine or melamine and to a method for the stabilisation of the UV absorption capacity of a composition by means of a mixture of at least one specific triazine or melamine together with 3-(4-tert-butylphenyl)-3-hydroxy-1-(4-methoxyphenyl)propan-1-one, 1-(4-tert-butylphenyl)-3-hydroxy-3-(4-methoxyphenyl)propan-1-one or a mixture of these compounds, particularly preferably together with 3-(4-tert-butylphenyl)-3-hydroxy-1-(4-methoxyphenyl)propan-1-one.
    Type: Application
    Filed: April 13, 2011
    Publication date: March 7, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Rene Peter Scheurich, Thomas Rudolph
  • Patent number: 8314045
    Abstract: A porous solid acid catalyst having high concentration of acidic sites and a large surface area includes a porous silica support and a sulfonated carbon layer disposed within the pores of the silica support. The catalyst, in certain embodiments, has a concentration of —SO3H groups of at least about 0.5 mmol/g and a predominant pore size of at least about 300 ?. The catalyst is used to catalyze a variety of acid-catalyzed reactions, including but not limited to alkylation, acylation, etherification, olefin hydration and alcohol dehydration, dimerization of olefin and bicyclic compounds, esterification and transesterification. For example, the catalyst can be used to catalyze esterification of free fatty acids (FFAs) and, in certain embodiments, to catalyze transesterification of triglycerides in fats and oils.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: November 20, 2012
    Assignee: Entreprises Sinoncelli S.A.R.L.
    Inventors: Jacques Sinoncelli, Sergey V. Gurevich
  • Publication number: 20120289721
    Abstract: A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding ?-hydroxyketone or ?-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The ?-hydroxyketones and ?-aminoketones thus obtainable are useful inter alia as photoinitiators.
    Type: Application
    Filed: July 25, 2012
    Publication date: November 15, 2012
    Inventors: NICOLE END, Reinhard H. Sommerlade, Yvonne Richter
  • Publication number: 20120289723
    Abstract: Indene derivatives that are utilizable as intermediates in the synthesis of the vitamin D2 derivative paricalcitol, which is useful as pharmaceutical are efficiently prepared by subjecting a vitamin D2 derivative such as 25-hydroxyvitamin D2 to a two-steps oxidation reaction using an oxidizing agent such as potassium permanganates and sodium periodate in a suitable solvent such as methanol and ethanol.
    Type: Application
    Filed: July 24, 2012
    Publication date: November 15, 2012
    Inventors: Asako TOYODA, Hazuki NAGAI
  • Patent number: 8269047
    Abstract: A method for preparing an ?-halo enal or enone from an unprotected propargyl alcohol and an electrophilic halogen source catalyzed by the combination of a gold catalyst complex and a metal co-catalyst complex is disclosed. The method can be further enhanced by addition of an additive that facilitates suppression of a des-halo derivative.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: September 18, 2012
    Assignee: Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada, Reno
    Inventors: Liming Zhang, Longwu Ye
  • Publication number: 20120029107
    Abstract: The invention pertains to novel oligofunctional photoinitiators of the formula (1) or (1A). R1 and R2 are methyl or together are —(CH2)5—; and n is 2 or 3, and the solvent in (1A) is water or an organic solvent; and their use in photopolymerizable compositions, in particular inks.
    Type: Application
    Filed: March 19, 2010
    Publication date: February 2, 2012
    Applicant: BASF SE
    Inventors: Ulrich Berens, Jean-Luc Birbaum, Katia Studer
  • Publication number: 20120012833
    Abstract: A light emitting device material precursor represented by the Formula (1): (wherein R1 to R6 each may be the same or different and is selected from the group consisting of hydrogen, alkyl groups, cycloalkyl groups, alkenyl groups, cycloalkenyl groups, alkoxy groups, alkylthio groups, arylether groups, aryl thioether groups, aryl groups and heteroaryl groups, with the proviso that at least one of R1 to R6 has a fused aromatic hydrocarbon having two or more rings).
    Type: Application
    Filed: March 29, 2010
    Publication date: January 19, 2012
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Nobuhiko Shirasawa, Yukari Jo, Shigeo Fujimori
  • Publication number: 20110301363
    Abstract: The invention relates to a method for carrying out an oxidation reaction for producing a product by heating a reaction medium containing a reactant and oxygen or an oxygen carrier in a reactor, wherein the reaction medium is brought into contact with a solid heating medium which may be heated by electromagnetic induction, which is surrounded by the reaction medium. The heating medium is heated by electromagnetic induction using an inductor, wherein an oxidation reaction is carried out on the first reactant to give a product and the product is separated from the heating medium. The inductor preferably generates an alternating field with a frequency in the range 1 to 100 kHz, preferably in the range 10 to 80 kHz and in particular up to 50 kHz.
    Type: Application
    Filed: August 16, 2011
    Publication date: December 8, 2011
    Inventors: Carsten FRIESE, Andreas Kirschning, Sascha-Volkan Ceylan
  • Publication number: 20110207967
    Abstract: Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesised rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer of from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst.
    Type: Application
    Filed: September 24, 2009
    Publication date: August 25, 2011
    Inventors: Lars Skattebol, Inger Aukrust, Marcel Sandberg
  • Publication number: 20110021794
    Abstract: Disclosed is a process for the manufacture of a compound of formula (I) wherein Hal represents fluoro or chloro, and R1 and R2 represent, independently from one another, hydrogen or Hal; in which process a compound of formula (II) is converted to a corresponding alkyl, fluoroalkyl or aryl sulfonic acid ester, which is then reacted with an alkali metal nitrite in the presence of a suitable crown ether in a polar non-nucleophilic solvent at a temperature of ?10 to 50° C. to give the compound of formula (I).
    Type: Application
    Filed: August 31, 2010
    Publication date: January 27, 2011
    Inventors: Marc Muller, Lin Xu
  • Publication number: 20110021806
    Abstract: A method for preparing an ?-halo enal or enone from an unprotected propargyl alcohol and an electrophilic halogen source catalyzed by the combination of a gold catalyst complex and a metal co-catalyst complex is disclosed. The method can be further enhanced by addition of an additive that facilitates suppression of a des-halo derivative.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 27, 2011
    Applicant: Board of Regents of the Nevada System of Higher Education, on behalf of the Univ of Nevada, Reno
    Inventors: Liming Zhang, Longwu Ye
  • Publication number: 20110015412
    Abstract: The invention relates to a process of reacting a primary allylic alcohol with a compound containing a) a metal selected from the group consisting of Ag, Au, Ce, Mn, Ni, Ru, Re, Zn and Co preferably Ag and b) an oxidant like TEMPO (2,2?,6,6?-tetra-methylpiperidin-1-oxyl) or its derivates and c) a co-oxidants selected from the group of peroxodisulfates (PDS), H2505, H2O2, NaOCl, O2, KOCl, and air.
    Type: Application
    Filed: February 15, 2008
    Publication date: January 20, 2011
    Applicant: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Jean-Francois Eckhardt, Manfred L. Eggersdorfer, Ramona Hinze, Wolfgang F. Hölderich, Michael H. Valkenberg
  • Publication number: 20100298582
    Abstract: Disclosed herein is a compound of formula (I): wherein: Bn represents benzyl; Me represents methyl; and Y represents an oxygen atom or a CH2 group. The compound of formula (I) can be used in the preparation of 7-benzyloxy-3-(4-methoxyphenyl)-2H-1-benzopyran, Preparation processes of said compound of formula (I) are also disclosed herein.
    Type: Application
    Filed: May 19, 2009
    Publication date: November 25, 2010
    Applicant: KaoHsiung Medical University
    Inventors: Eng-Chi Wang, Sie-Rong Li
  • Patent number: 7829745
    Abstract: Described herein are methods for synthesizing 1-aryl-2-tetralones in an efficient and highly selective manner. The reaction involves a one-step procedure for coupling an aryl halide to a 2-tetralone, where coupling occurs substantially at the 1-position of the 2-tetralone.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: November 9, 2010
    Assignee: Corning Incorporated
    Inventor: Clemens Rudolf Horn
  • Patent number: 7820836
    Abstract: A process for the preparation of hydroxylated isoflavones by reacting in a Hoesch reaction using an alkanoic acid alkyl ester as solvent a phenol with a phenylacetonitrile to yield a 1,2-diphenyl-ethanone and transforming the ethanone into an isoflavone by well-known methods.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: October 26, 2010
    Assignee: DSM IP Assets B.V.
    Inventors: August Rüttimann, Edith Maria Rüittmann-Wechsler, legal representative, Natalie Christina Rüittmann, legal representative, Pascal Michael Rüittmann, legal representative, Jochen Stangl
  • Publication number: 20100130758
    Abstract: Disclosed are a catalyst including a hydrotalcite and, immobilized on a surface thereof, particles of at least one metal selected from the group consisting of Cu, Ag, and Au; a method for producing a carbonyl compound through dehydrogenation of an alcohol in the presence of the catalyst; and a method for producing a carbonyl compound through dehydrogenation of an alcohol in the presence of a catalyst including a hydrotalcite and, immobilized on a surface thereof, particles of a metal, in which dehydrogenation is performed in the absence of oxygen.
    Type: Application
    Filed: March 9, 2007
    Publication date: May 27, 2010
    Inventors: Kiyotomi Kaneda, Noritsugu Yamasaki
  • Patent number: 7687668
    Abstract: Process for preparing 4,4?-difluorobenzophenone, characterized in that, in a first step, fluorobenzene is reacted with formaldehyde under catalysis by organic sulphonic acids to give difluorodiphenylmethane, the product obtained is isolated, and, in a second step, oxidized with nitric acid to give 4,4?-difluorobenzophenone. 4,4?-Difluorobenzophenone (4,4?-DFBP) is the central starting material for the preparation of aromatic polyether ketones.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: March 30, 2010
    Assignee: Evonik Fibres GmbH
    Inventors: Harald Rögl, Markus Ungerank
  • Publication number: 20090317753
    Abstract: A method for producing highly purified fused aromatic ring compounds with high yield by a simpler method. A method for producing a fused aromatic ring compound comprising irradiating the bicyclo compound containing at least one bicyclo ring represented by formula (1) in a molecule with light to detach a leaving group X from a residual part to form an aromatic ring: wherein R1 and R3 each denotes a group to form an aromatic ring or a heteroaromatic ring which may be substituted, together with a group to which each thereof is bonded; R2 and R4 each denotes a hydrogen atom, an alkyl group, an alkoxy group, an ester group or a phenyl group; and X is a leaving group, which denotes a carbonyl group or —N?.
    Type: Application
    Filed: September 1, 2009
    Publication date: December 24, 2009
    Applicant: CANON KABUSHIKI KAISHA
    Inventors: Hidemitsu Uno, Noboru Ono
  • Publication number: 20090299102
    Abstract: The invention provides methods and an apparatus useful for site-isolating reagents or catalysts during chemical reactions. The methods and apparatus are useful for carrying out cascade or domino reactions.
    Type: Application
    Filed: June 2, 2009
    Publication date: December 3, 2009
    Applicant: University of Iowa Research Foundation
    Inventors: Ned Bowden, Michael Brett Runge, Alan Lee Miller, III
  • Publication number: 20090287001
    Abstract: A process for the preparation of hydroxylated isoflavones by reacting in a Hoesch reaction using an alkanoic acid alkyl ester as solvent a phenol with a phenylacetonitrile to yield a 1,2-diphenyl-ethanone and transforming the ethanone into an isoflavone by well-known methods.
    Type: Application
    Filed: April 10, 2006
    Publication date: November 19, 2009
    Inventors: August Rüttimann, Edith Maria Rüitmann-Wechsir, Natalie Christina Rüittmann, Arlesheim Rüittmann, Jochen Stangl
  • Publication number: 20090264680
    Abstract: A process for the preparation of 4-trifluoromethylvalerophenone is described. The process described is a three step process comprising the synthesis of organomagnesium specie, coupling reaction between the organomagnesium specie and trifluoromethylbenzonitrile or trifluoromethylbenzoyl chloride and preferably a purification of the product obtained in suitable reaction conditions. In the process an extraction phase of the final product is not required.
    Type: Application
    Filed: July 7, 2004
    Publication date: October 22, 2009
    Inventors: Andrea Castellin, Luca Gregori, Guadalupe Gonzales Trueba, Albino Rubello, Andrea Nicole
  • Patent number: 7553988
    Abstract: A method is provided for producing a specific crosscoupling compound and a specific catalyst for producing the compound. The method includes reacting in the presence of a base and a nickel compound catalyst organic halide of the formula n?(R1X1n), wherein R1 is a hydrocarbon group and the ? and ? carbons to X? are sp3 carbon atoms; X1 is a chlorine, bromine, or iodine atoms, and n and n1 are 1 or 2 but not both 2, with a compound having the formula m{R2(BX22)n?} where an R2 is an aryl, heteroaryl, or alkenyl group, and n? is 1 or 2, X2 is independently a hydroxyl group, an alkoxy or arylalkoxy group or X22 together form an alkylenedioxy or arylenedioxy group, and m represents 1 or 2 but m?n, and the boron atom is bonded to a sp2 carbon atom of R2 group or a boronic acid trimer anhydride.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: June 30, 2009
    Assignee: Sumitomo Chemical Company, Limted
    Inventors: Tamon Itahashi, Takashi Kamikawa
  • Publication number: 20080200732
    Abstract: The present invention relates to novel intermediates for the preparation of coenzymes, processes for the preparation of the intermediates and an improved process for the preparation of Coenzymes. The present invention particularly relates to an improved process for the preparation of Coenzyme Q, more particularly for Conenzyme Q9 and Coenzyme Q10. Still more particularly this invention relates to regio and stereo controlled process for the preparation of Coenzyme Q9 and Coenzyme Q10 of the formula I where n=9 (Coenzyme CoQ9), and where n=10.
    Type: Application
    Filed: June 21, 2006
    Publication date: August 21, 2008
    Applicant: Nicholas Piramal India Limited
    Inventors: Abhay Upare, Nitin Yeshwant Pawar, Ganesh Wagh, Amit Chavan, Mita Roy, Hariharan Sivaramakrishnan
  • Patent number: 7332632
    Abstract: The method for producing an aldehyde or ketone compound from a corresponding primary or secondary alcohol at relatively high temperature within a short time with a high yield including a step (1) of reacting a sulfoxide compound with an activating agent to produce an activation reaction product; a step (2) of reacting the activation reaction product with a primary or secondary alcohol to produce an alkoxysulfonium salt; and a step (3) of reacting the reaction product with a base to produce an aldehyde or ketone; wherein at least one of the steps, preferably the step (1) and step (2), are carried out by using a microreactor.
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: February 19, 2008
    Assignee: Ubē Industries, Ltd.
    Inventors: Kikuo Ataka, Hiroyuki Miyata, Tatsuya Kawaguchi, Junichi Yoshida, Kazuhiro Mae
  • Patent number: 7262328
    Abstract: The invention relates to a method for the production of a.) aldehydes of formula (II): R1—CHO and b.) aldehydes of formula (III): R1—C(O)—R2 by reacting a.) primary alcohols (R1CH2—OH) or b.) secondary alcohols (R1—CH(OH)—R2) with cyclic phosphonic acid anhydrides in the presence of dialkyl-, diaryl- and/or alkyl-aryl sulphonic oxides at a temperature in the region of between ?100 to +120° C., whereby R1 and/or R2 represent H, a substituted linear or branched C1-C12-alkyl radical, a substituted C3-C10 cycloalkyl-, alkenyl-, aryl- or heteroaryl radical. A cyclic phosphonic acid anhydride is used, preferably, as a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane of formula (I), wherein R? independently represents allyl, aryl or open-chained or branched C1-C12-alkyl-radicals.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: August 28, 2007
    Assignee: Archimica GmbH
    Inventors: Andreas Meudt, Stefan Scherer, Claudius Boehm
  • Patent number: 7238832
    Abstract: There is provided a method for producing a coupling compound of formula (1): (Y—)(n?1)R1—R2—(R1)(n??1)??(1) wherein R1, R2 n and n? are as defined below, Y is R2 or X as defined below, which method comprises reacting an organic halogen compound of formula (2): n?(R1X1n)??(2) wherein X1 represents a bromine or iodine, R1 represents a substituted or unsubstituted, linear, branched or cyclic hydrocarbon group of which ? and ? carbon atoms in relation to X1 are sp3 carbon atoms, n and n? each independently represent an integer of 1 or 2, and provided that n and n? do not simultaneously represent 2, with an organic boron compound of formula (3): m{R2(BX22)n?}??(3) wherein R2 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted alkenyl group and the boron atom is bonded with a sp2 carbon atom thereof, X2 represents a hydroxyl or alkoxy group, n? is as defined above, m represents an integer of 1 or 2, and m is not more than n, in the presence of a catalyst comprising a) a nick
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: July 3, 2007
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Tamon Itahashi, Takashi Kamikawa
  • Patent number: 7235699
    Abstract: The present invention relates to alkoxy-substituted indanes, their preparation and use and to the preparation and use of the corresponding alkoxy-substituted indanones.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: June 26, 2007
    Assignee: Symrise GmbH & Co. KG
    Inventor: Oskar Koch