Bicyclo Ring System Patents (Class 568/327)
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Patent number: 7179306Abstract: The present disclosure relates to the process, for dyeing keratin materials, comprising applying to the fibers a composition comprising, in a medium appropriate for dyeing, at least one ninhydrin derivative, which may optionally be combined with at least one compound comprising a labile hydrogen. Further disclosed herein is a multi-component hair dye composition, and a multi-compartment kit comprising same.Type: GrantFiled: July 26, 2004Date of Patent: February 20, 2007Assignee: L'Oreal S.A.Inventors: Grégory Plos, Luc Gourlaouen
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Patent number: 7179304Abstract: The present disclosure relates to the process, for dyeing keratin materials, comprising applying to the keratin materials a composition comprising, in a medium appropriate for dyeing, at least one polycyclic aromatic vicinal trione, which may be optionally combined with at least one compound comprising a liable hydrogen. Further disclosed herein is a cosmetic dyeing composition, a multicomponent hair dye composition, and a multicompartment kit comprising the same.Type: GrantFiled: July 26, 2004Date of Patent: February 20, 2007Assignee: L'Oreal S.A.Inventors: Grégory Plos, Luc Gourlaouen
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Patent number: 7175671Abstract: The invention relates to the use for of compositions dyeing keratin materials containing, in a medium that is suitable for dyeing, at least one compound of formula (I) in which X and Y, independently of one another, are chosen from a CH group and a nitrogen atom, R is chosen from aromatic mono- or poly-cyclic groups with fused or non-fused rings, wherein the groups have at least 5 members and optionally comprise at least one hetero atom chosen from nitrogen, oxygen, sulphur and phosphorus. Processes and kits using these compositions are also disclosed.Type: GrantFiled: July 26, 2004Date of Patent: February 13, 2007Assignee: L'Oreal S.A.Inventors: Grégory Plos, Luc Gourlaouen
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Patent number: 7087790Abstract: The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective antioxidant and anti-inflammatory agents. The present invention also provides novel method of synthesizing benzotropolone compounds in high yields and method of treating inflammatory conditions using benzotropolone containing compounds.Type: GrantFiled: August 29, 2003Date of Patent: August 8, 2006Assignee: Rutgers, The State University of New JerseyInventors: Chi-Tang Ho, Geetha Ghai, Shengmin Sang, Jin-Woo Jhoo, Mou-Tuan Huang, Robert T. Rosen, Slavik Dushenkov
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Patent number: 6995290Abstract: The present invention refers to solid mixtures of alpha hydroxycarbonyl derivatives of alpha-methylstyrene oligomers containing at least 90% of the dimer isomers, the dimer isomer ratio being between 2.5 and 7, to their preparation and to their use as photoinitiators in photopolymerisation.Type: GrantFiled: April 3, 2002Date of Patent: February 7, 2006Assignee: Lamberti SpAInventors: Marco Visconti, Gabriele Norcini, Giuseppe Li Bassi
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Patent number: 6956061Abstract: The present invention relates to compounds of the formula (I): which are produced by the plant Garcinia punctata, chemical derivatives derived therefrom, a process for their preparation, and their use as pharmaceuticals, in particular for the treatment and/or prophylaxis of bacterial infectious diseases.Type: GrantFiled: July 31, 2003Date of Patent: October 18, 2005Assignee: Aventis Pharma Deutschland GmbHInventors: Matthias Schiell, Michael Kurz, Sabine Haag-Richter
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Patent number: 6953850Abstract: The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal protection strategy allows for the specific deprotection of any substituent ono the saccharide ring, and greatly facilitates targeted or library-focused carbohydrate-related syntheses. In particular, the invention provides a universal monosaccharide building block of General Formula (I) or General Formula (II) in which A is a leaving group; X is hydrogen, O, N or N3; X1 is hydrogen, —CH2O—, —CH2NH—, —CH3, —CH2N3 or —COO—; and B, C, D and E are protecting groups that can be cleaved orthogonally, and in which B, C, D and E are absent when X is hydrogen or N3, and E is absent when X1 is hydrogen, CH3 or N3.Type: GrantFiled: January 18, 2000Date of Patent: October 11, 2005Assignee: Alchemia Pty. Ltd.Inventors: Gyula Dekany, John Papagerogiou, Laurent Francois Bornaghi
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Patent number: 6949680Abstract: A compound of formula wherein Y represents a pyridyl group, or a phenyl group of formula wherein R3 represents a hydrogen atom, a CF3 group or an alkoxy group, R4 represents a hydrogen atom, an alkyl group, or a CF3 group, R5 represents a hydrogen atom, an alkyl group, a CF3 group or an alkoxy group, and R1 and R2 are the substituents of a terminal alkene of formula wherein R1 represents an alkyl or alkylene group, a mono- or poly-cycloalkyl group, or a phenyl group that optionally includes one or several hetero-atoms of oxygen, nitrogen, phosphorous or sulfur; R2 represents a hydrogen atom, an alkyl or alkylene group, a mono- or poly-cycloalkyl group, or a phenyl group that optionally includes one or several hetero-atoms of oxygen, nitrogen, phosphorous and sulfur.Type: GrantFiled: October 15, 2002Date of Patent: September 27, 2005Assignee: Firmenich SAInventor: Andreas Herrmann
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Patent number: 6939845Abstract: The present invention provides a fragrance precursor of formula I: that is capable of forming a fragrant ketone of formula II: and a fragrant lactone of formula III:Type: GrantFiled: June 18, 2001Date of Patent: September 6, 2005Assignee: Givaudan SAInventors: Markus Gautschi, Caroline Plessis, Samuel Derrer
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Patent number: 6887904Abstract: Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology.Type: GrantFiled: December 4, 2002Date of Patent: May 3, 2005Assignee: Aventis Pharma S. A.Inventors: Patrick Mailliet, Marc Capet, Gilles Tiraboschi, Thomas Caulfield
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Patent number: 6884848Abstract: Fluoropolymers containing the benzocyclobutenone moiety are provided.Type: GrantFiled: September 13, 2002Date of Patent: April 26, 2005Assignee: Avery Dennison CorporationInventors: Kai Li, Yukihiko Sasaki, Prakash Mallya, Pradeep Iyer
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Patent number: 6867332Abstract: A process is specified by which the xanthohumol present in hops can be isolated in high yield in an economical manner. In the process an ethanol pure resin extract is first extracted with a liquid or supercritical solvent in which the xanthohumol is insoluble and the resultant extraction residue is first washed with a first solvent mixture and then the extraction residue which has been washed with the first solvent mixture is, after removing the first solvent mixture, extracted with a second solvent mixture, the first solvent mixture having a higher polarity than the second solvent mixture. The hop extract produced from the second solvent mixture has a xanthohumol content of at least 85% by weight.Type: GrantFiled: July 23, 2003Date of Patent: March 15, 2005Assignee: Hallertauer Hopfenveredelungsgesellschaft m.b.H.Inventors: Martin Biendl, Hans Becker, Aslieh Nookandeh
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Patent number: 6855696Abstract: The present invention provides illudin analogs of the general formula I: wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising compounds of formula I, intermediates and processes useful for preparing compounds of formula I, and methods comprising inhibiting tumor growth or treating cancer by administering one or more compounds of formula I.Type: GrantFiled: November 5, 2001Date of Patent: February 15, 2005Assignee: The Regents of the University of CaliforniaInventors: Trevor C. McMorris, Michael J. Kelner
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Patent number: 6852894Abstract: An oxygen scavenging composition or system is provided comprising an oxygen scavenging material, a photoinitiator, and at least one catalyst effective in catalyzing an oxygen scavenging reaction, wherein the photoinitiator comprises a benzophenone derivative containing at least two benzophenone moieties. A film, a multi-phase composition, a multi-layer composition, a multi-layer film, an article comprising the oxygen scavenging composition, a method for preparing the oxygen scavenging composition, and a method for scavenging oxygen are also provided. Non-extractable benzophenone derivative photoinitiators and methods for preparing same are also provided.Type: GrantFiled: November 7, 2002Date of Patent: February 8, 2005Assignee: Chevron Phillips Chemical Company LPInventor: Ta Yen Ching
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Patent number: 6815563Abstract: A process for preparing bicyclic 1,3-diketones of the formula I where R1, R2, R3 and R4 are hydrogen, C1-C4-alkyl, C1-C4-alkoxy-carbonyl, halogen, cyano, nitro, C1-C4-alkylthio, C1-C4-alkylsulfenyl or C1-C4-alkylsulfonyl and Z is C1-C4-alkylene, O, S, N—R5 where R5 is C1-C4-alkyl or C1-C4-alkylcarbonyl, which comprises a) reacting a bicyclic olefin of the formula II with haloform in the presence of a base to give the ring-expanded product of the formula III where R1-R4 and Z are as defined above and X is halogen; b) hydrolyzing the allylic halogen of the compound of the formula III to the allyl alcohol of the formula IV c) oxidizing the allyl alcohol of the formula IV to the unsaturated ketone of the formula V d) reacting the ketone of the formula V with a nucleophilic ion Y− which stabilizes a negative charge to give the ketone of the formula VI e) hydrolyzing the ketone of the formula VI to thType: GrantFiled: January 6, 2003Date of Patent: November 9, 2004Assignee: BASF AktiengesellschaftInventors: Klaus Langemann, Ulf Misslitz, Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Thorsten Volk, Guido Mayer
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Patent number: 6790998Abstract: The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II): wherein R1, R2 and R3 independently of each other are hydrogen, methyl, methoxy, hydroxy, hydroxymethyl, carbamoyl, sulphamoyl or halogen, to form an enantiomerically enriched compound of formula (IIIa) or (IIIb): wherein R1, R2 and R3 are as defined above; b) subjecting the compound of formula (IIIa) or (IIIb) to a sigmatropic rearrangement to form a corresponding enantiomerically enriched compound of formula (IVa) or (IVb): wherein R1, R2 and R3 are as defined above; c) subjecting the compound of formula (IVa) or (IVb) to a Baeyer-Villiger oxidation to form a corresponding enantiomerically enriched compound of the general formula (Va) or (Vb).Type: GrantFiled: March 28, 2003Date of Patent: September 14, 2004Assignee: Pharmacia ABInventors: Pher G. Andersson, Christian Hedberg
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Patent number: 6787672Abstract: This invention pertains to substituted chalcones, specifically substituted 1-(4-methoxyphenyl)-3-(3,5-dimethoxyphenyl)prop-1-en-3-ones, which have therapeutic application, for example, as potent antiproliferative agents and antiinflammatory agents, and which have the formula (I) wherein: X is —H, —OH, —OC(═O)R3, —OS(═O)2OH, or —OP(═O)(OH)2; Y is —H or a C1-4alkyl group; Z is —H or —OCH3; R1 is —H, a C1-4alkyl group, or C1-4fluoroalkyl group; R2 is —H, a C1-4alkyl group, or C1-4fluoroalkyl group; and, R3 is —H, a C1-6alkyl group, a C3-20 heterocyclyl group, or a C5-20aryl group; and pharmaceutically acceptable salts, esters, and protected forms thereof.Type: GrantFiled: September 26, 2002Date of Patent: September 7, 2004Assignee: Cancer Research Technology LimitedInventors: Gerard Andrew Potter, Paul Crispin Butler, Elugba Wanogho
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Patent number: 6777447Abstract: Benzylidene cyclohexanone, cyclopentanone and acteone derivatives and therapeutic methods of using same are disclosed. The compounds are non-toxic and exhibit potent anti-inflammatory, antibacterial and antioxidation activity. Also, certain compounds of the invention inhibit glutathione S-transferase (“GST”), but do not irritate the gastrointestinal tract. Pharmaceutical compositions containing the compounds of the invention and pharmaceutically acceptable carriers are also disclosed.Type: GrantFiled: February 27, 2002Date of Patent: August 17, 2004Inventors: Mochammad Samhoedi Reksohadiprodjo, Henk Timmerman, Sardjiman Dummy, Supardjan Amir Margono, Sudibyo Martono, Sugiyanto Dummy, Lukman Rahman Hakim, Nurlaila Dummy, Arief Rahman Hakim, Ika Puspitasari, Arief Nurrochmad, Purwantiningsih Dummy, Oetari Dummy, Tedjo Yuwono
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Patent number: 6765089Abstract: This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups that are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis.Type: GrantFiled: March 20, 2000Date of Patent: July 20, 2004Assignee: Alchemia Pty LtdInventors: Istvan Toth, Gyula Dekany, Barry Kellam
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Patent number: 6723843Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.Type: GrantFiled: August 30, 2002Date of Patent: April 20, 2004Assignee: Alchemia PTY LTDInventors: Istvan Toth, Gyula Dekany, Barry Kellam
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Patent number: 6664272Abstract: The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.Type: GrantFiled: December 4, 2000Date of Patent: December 16, 2003Assignee: Emory UniversityInventors: James P. Snyder, Matthew C. Davis, Brian Adams, Mamoru Shoji, Dennis C. Liotta, Eva M. Ferstl, Ustun B. Sunay
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Patent number: 6660892Abstract: This invention is a process for synthesizing aliphatic 1,3-diols in one step by hydroformylation and hydrogenation of oxirane, carbon monoxide, and hydrogen employing a catalyst comprising a cobalt carbonyl compound and a cocatalyst metal compound ligated with a ligand in a ligand to cocatalyst metal atom molar ratio in the range of 0.2:1.0 to 0.6:1.0, optionally in the presence of a promoter, where recovery of product is preferably accomplished via water extraction of a diol rich phase from the bulk reaction mixture. The process modifications can, particularly in combination, be beneficial with respect to product recovery, catalyst recycle, and overall economics of a one-step process for producing aliphatic 1,3-diols.Type: GrantFiled: February 7, 2003Date of Patent: December 9, 2003Assignee: Shell Oil CompanyInventors: Joseph Broun Powell, Paul Richard Weider, John Frederick Knifton, Kevin Dale Allen, Lynn Henry Slaugh, Juan Pedro Arhancet
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Publication number: 20030166643Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1Type: ApplicationFiled: December 11, 2002Publication date: September 4, 2003Applicant: WyethInventors: Robert E. McDevitt, Folake O. Adebi, Heather A. Harris, James C. Keith, Leo M. Albert
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Patent number: 6603046Abstract: The invention is drawn to novel bis-aromatic a,&bgr;-unsaturated ketones. The compounds are useful in the treatment and prophylaxis of diseases caused by parasites or bacteria.Type: GrantFiled: May 27, 1998Date of Patent: August 5, 2003Assignee: Lica Pharmaceuticals A/SInventors: Arsalan Kharazmi, Søren Brøgger Christensen, Chen Ming, Thor Grundtvig Theander
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Patent number: 6599861Abstract: Compounds of formula I wherein the substituents are defined as in claim 1, as well as the agronomically acceptable salts, isomers and enantiomers of these compounds, as well as the agronomically acceptable salts/N-oxides/isomers/enantiomers of these compounds, are eminently suitable for use as herbicides.Type: GrantFiled: June 21, 2001Date of Patent: July 29, 2003Assignee: Syngenta Participations AGInventors: Jürgen Schaetzer, Alain De Mesmaeker, Shy-Fuh Lee
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Publication number: 20030125584Abstract: The invention relates to the use of 6-alkylindan-1-ones as fragrances, to a process for their preparation, to fragrance mixtures comprising 6-alkylindan-1-ones, and to perfumed products comprising 6-alkylindan-1-ones.Type: ApplicationFiled: November 8, 2002Publication date: July 3, 2003Inventors: Steffen Sonnenberg, Oskar Koch, Bertrand Duchaufour
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Publication number: 20030096847Abstract: Amide compounds of the formula: 1Type: ApplicationFiled: November 1, 2002Publication date: May 22, 2003Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Akira Yamada, Satoshi Aoki
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Patent number: 6566537Abstract: The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II): wherein R1, R2 and R3 independently of each other are hydrogen, methyl, methoxy, hydroxy, hydroxymethyl, carbamoyl, sulphamoyl or halogen, to form an enantiomerically enriched compound of formula (IIIa) or (IIIb): wherein R1, R2 and R3 are as defined above; b) subjecting the compound of formula (IIIa) or (IIb) to a sigmatropic rearrangement to form a corresponding enantiomerically enriched compound of formula (IVa) or (IVb): wherein R1, R2 and R3 are as defined above; c) subjecting the compound of formula (IVa) or (IVb) to a Baeyer-Villiger oxidation to form a corresponding enantiomerically enriched compound of the general formula (Va) or (Vb): wherein R1, R2 and R3 are as defined above; d) converting the compouType: GrantFiled: July 31, 2001Date of Patent: May 20, 2003Assignee: Pharmacia ABInventors: Pher G. Andersson, Christian Hedberg
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Patent number: 6548679Abstract: The present invention provides compounds of general formula I or II: wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising compounds of formula I or II, intermediates and processes useful for preparing compounds of formula I or II, and methods comprising inhibiting tumor growth or treating cancer by administering one or more compounds of formula I or II.Type: GrantFiled: August 17, 2000Date of Patent: April 15, 2003Assignee: The Regents of the University of CaliforniaInventors: Trevor C. McMorris, Michael J. Kelner
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Patent number: 6548710Abstract: The present invention relates to a process for preparing 1-indanones of formula I: and isomers thereof, wherein R1, R2, R3, R4, R5, and R6 independently represent H or a C1-C20 hydrocarbon group or R1 and R2 or R2 and R3 or R3 and R4 and/or R5 and R6 together with the carbon atoms to which they are attached form a saturated or unsaturated 5- or 6-membered ring, said hydrocarbon group and/or said ring optionally containing one or more hetero atoms, said ring optionally being substituted with a C1-C4 hydrocarbon group, said process comprising reacting a compound of formula II: wherein R1, R2, R3, R4, R5, and R6 have the same meaning as defined above, with a chlorinating agent, followed by reaction with a Friedel-Crafts catalyst. The invention further relates to the preparation of the corresponding indenes.Type: GrantFiled: October 31, 2001Date of Patent: April 15, 2003Assignee: Akzo Nobel N.V.Inventor: Richard Herman Woudenberg
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Patent number: 6528676Abstract: The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.Type: GrantFiled: February 2, 1999Date of Patent: March 4, 2003Assignee: The Children's Medical Center CorporationInventors: Robert John D'Amato, Moses Judah Folkman
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Publication number: 20030032549Abstract: A compound useful as a cocatalyst or cocatalyst component, especially for use as an addition polymerization catalyst compound, corresponding to the formula: (A*+a)b(Z*J*j)−cd, wherein:Type: ApplicationFiled: June 4, 2002Publication date: February 13, 2003Inventor: Alexander Vogel
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Patent number: 6515184Abstract: The present invention relates to novel bicyclic cyclopentane-1,3-dione derivatives of the formula (I) to a process for their preparation and to their use as pesticides and herbicides.Type: GrantFiled: April 6, 1998Date of Patent: February 4, 2003Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Michael Ruther, Alan Graff, Arno Widdig, Jacques Dumas, Christoph Erdelen, Peter Dahmen, Markus Dollinger, Ulrike Wachendorff-Neumann
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Patent number: 6492563Abstract: The present invention is a fragrance precursor of formula I: for a fragrant ketone of formula II: and a fragrant ester of formula III: wherein, R1 to R5 represent independently H, —NO2, linear or branched C1-C6-alkyl, C1-C6-alkenyl, C1-C6-alkinyl or C1-C4-alkoxy, R1 and R2,R2 and R3, R3 and R4, and R4 and R5 may form together one or two aliphatic or aromatic rings, R6 and R7 are independently H, linear or branched C1-C6-alkyl-, C1-C6-alkenyl, C1-C6-alkinyl, and R8 and R9 are the residues of an acid R8-COOH and an alcohol R9OH respectively forming the fragrant ester of formula III. A method for providing an odor by admixing with a product a fragrance precursor as detailed above.Type: GrantFiled: April 10, 2001Date of Patent: December 10, 2002Assignee: Givaudan SAInventors: Markus Gautschi, Caroline Plessis, Samuel Derrer
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Patent number: 6441244Abstract: The invention relates to new compounds of the formula (I) in which R is phenyl, C1-4alkyl-, C1-4alkoxy- or halogen-substituted phenyl, naphthyl or an aromatic ring containing heteroatoms; X is O or S; R1 and R2 are each a methyl radical or R1 and R2 together are a C4-8alkylene radical; Y is hydroxyl, C1-12alkoxy, C1-4alkylamino, di-C1-4alkylamino or a piperidine or morpholine ring that is attached by its nitrogen atom; to a process for preparing them and to their use as photoinitiators and/or photosensitizers.Type: GrantFiled: July 12, 2001Date of Patent: August 27, 2002Assignee: Clariant Finance (BVI) LimitedInventors: Lajos Avar, René Bär, Victor Sanahuja
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Patent number: 6433021Abstract: Indane compounds of general formulae (1) to (4) and their pharmaceutical use, particularly to achieve mast cell stabilising activity and/or anti-inflammatory activity are described.Type: GrantFiled: December 3, 1999Date of Patent: August 13, 2002Assignee: Venantius LimitedInventors: Neil Frankish, Helen Sheridan, John Walsh, Michael Jordan
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Patent number: 6410794Abstract: Improved processes for preparation of tetralones in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic tetralone derivative. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired tetralone derivative enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer may be racemized and recycled to the resolution phase to avoid loss.Type: GrantFiled: November 3, 2000Date of Patent: June 25, 2002Assignee: UOP LLCInventors: Herman A. Zinnen, Mark J. Gattuso
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Patent number: 6362376Abstract: 2-Benzyloxyalkyl halophenones of the formula (3): wherein X1 and X2 are each independently H, Cl or F, provided that at least one of X1 and X2 is Cl or F; one of R3 and R4 is H and the other is optionally substituted benzyloxy; and R5 is an unsubstituted alkyl, preferably a C1-6 alkyl group. The compounds are useful as intermediates for preparing 2-hydroxyalkyl halophenones.Type: GrantFiled: August 8, 2001Date of Patent: March 26, 2002Assignee: Avecia LimitedInventors: John Crosby, Kevin Douglas Bailey, Michael John Monteith
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Publication number: 20020019382Abstract: The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.Type: ApplicationFiled: December 4, 2000Publication date: February 14, 2002Inventors: James P. Snyder, Matthew C. Davis, Brian Adams, Mamoru Shoji, Dennis C. Liotta, Eva M. Ferstl, Ustun B. Sunay
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Patent number: 6326369Abstract: A compound of the formula: wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the principal chain is 1 to 15; Y represents an acyl, or a hydroxy, an amino or an aromatic group, each of which may be substituted; and ring A represents a 5- to 8-membered ring which may be further substituted apart from —X—Y, or a salt thereof is useful as a pharmaceutical composition for preventing or treating disease related to mitochondrial dysfunction.Type: GrantFiled: July 6, 1999Date of Patent: December 4, 2001Assignee: Takeda Chemicals Industries, Ltd.Inventors: Kaneyoshi Kato, Taiichi Ohra, Masaomi Miyamoto
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Publication number: 20010034454Abstract: Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo[b]thiophenes and benzo[b]thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described.Type: ApplicationFiled: December 15, 2000Publication date: October 25, 2001Applicant: BYLOR UNIVERSITY AND ARIZONA DESEASE CONTROL RESEARCH COMMISSIONInventors: Kevin G. Pinney, George R. Pettit, Vani P. Mocharla, Maria del Pilar Mejia, Anupama Shirali
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Patent number: 6300376Abstract: Indane dimer compounds and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity are described.Type: GrantFiled: June 8, 1998Date of Patent: October 9, 2001Assignee: Venantius LimitedInventors: John Walsh, Neil Frankish, Helen Sheridan, Ronan Farrell, William Byrne
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Patent number: 6297399Abstract: Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity as described, wherein in formula (7) R2 to R13, in formula (8) R1 and R3 and R13 are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitrile, heterocyclic groups containing heretro atoms containing one or more of N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 carbon atoms which may sType: GrantFiled: June 8, 1998Date of Patent: October 2, 2001Assignee: Venantius LimitedInventors: John Walsh, Neil Frankish, Helen Sheridan, William Byrne
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Patent number: 6278025Abstract: The invention relates to a process for the preparation of substituted dibenzoylmethane compounds of the formula I, which comprises a1) condensing benzaldehydes of the formula II with acetophenones of the formula III to give the chalkones of the formula IV or a2) condensing benzaldehydes of the formula V with acetophenones of the formula VI to give the chalkones of the formula VII b) converting the chalcones of the formulae IV and VII into the dibenzoylmethane compounds of the formula I, the substituents R1 and R2 being defined as in the description.Type: GrantFiled: October 13, 1999Date of Patent: August 21, 2001Assignee: BASF AktiengesellschaftInventors: Thorsten Habeck, Frank Prechtl
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Patent number: 6271411Abstract: A process is disclosed for preparing 2-aryl-substituted indenes by reacting an indene with an arene compound substituted with an halogen atom, preferably a iodine atom, or with an organosulphonate group, said reaction being carried out in a basic medium in the presence of a palladium catalyst. The compounds obtainable by this process can be used to prepare metallocene compounds with transition metals such as titanium, zirconium or hafnium, which are useful as catalyst components in the polymerization of olefins.Type: GrantFiled: December 11, 1998Date of Patent: August 7, 2001Assignee: Montell Technology Company bvInventors: Ilya E. Nifant'ev, Yuri A. Dubitsky, Alexander A. Sitnikov
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Patent number: 6268535Abstract: The present invention is a method of preparing a 3-aryl-1-indanamine represented by structural formula I: and physiologically acceptable salts thereof. In structure I, phenyl ring A can be unsubstituted or substituted with 1-4 substitutents. R1 is an aromatic group which can be substituted or unsubstituted. R2 and R3 are each, independently, hydrogen, an aliphantic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, an aralkyl group, or a substituted aralkyl group. Alternatively, R2 and R3, taken together with the nitrogen substitutent on the indan ring, form a non-aromatic ring system having 1-2 heteroatoms.Type: GrantFiled: January 7, 1999Date of Patent: July 31, 2001Assignee: Pharm-Eco Laboratories, Inc.Inventors: Adel M. Moussa, Reem Haider, Heather Taft, Jurjus Jurayj, Weiheng Wang, HaeSuk Suh
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Patent number: 6251833Abstract: The present invention relates to novel 2-aryl-3-hydroxy-&Dgr;2-cyclopentene-1-one derivatives of the formula (I) in which A, B, D1, D2, G, W, X, Y and Z are each as defined in the description, to processes for their preparation and to their use as herbicides and pesticides.Type: GrantFiled: August 31, 1999Date of Patent: June 26, 2001Inventors: Christoph Erdelen, Ulrike Wachendorff-Neumann, Reiner Fischer, Alan Graff, Norbert Mencke, Andreas Turberg
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Patent number: 6162930Abstract: Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo[b]thiophenes and benzo[b]thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described.Type: GrantFiled: December 3, 1999Date of Patent: December 19, 2000Assignee: Baylor UniversityInventors: Kevin G. Pinney, George R. Pettit, Vani P. Mocharla, Maria del Pilar Mejia, Anupama Shirali
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Patent number: 6147224Abstract: Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR.sub.1 R.sub.1).sub.n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent aryl or 5 or 6 membered heteroaryl radical having 1 to 3 heteroatoms selected from N, S and O, said aryl or heteroaryl groups being unsubstituted, or substituted with 1 to 3 C.sub.1-6 alkyl or with 1 to 3 C.sub.1-6 fluoroalkyl groups; and the remaining symbols have the meaning described in the specification, have RXR selective retinoid agonist-like activity.Type: GrantFiled: October 1, 1998Date of Patent: November 14, 2000Assignee: Allergan Sales, Inc.Inventors: Vidyasagar Vuligonda, Kwok Yin Tsang, Jayasree Vasudevan, Roshantha A. Chandraratna
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Patent number: 6133303Abstract: The present invention provides compounds of Formula (I). The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula (I).Type: GrantFiled: August 2, 1999Date of Patent: October 17, 2000Assignee: Warner-Lambert CompanyInventors: Jack Bikker, Ellen Myra Dobrusin, Annette Marian Doherty, Matthew Drowns, James Stanley Kaltenbronn, Juergen Kleinschroth, Dennis Joseph McNamara, John Quin, III, Joseph Thomas Repine, Marcin Stasiak