Bicyclo Ring System Patents (Class 568/327)
  • Patent number: 4291061
    Abstract: 2,3-Dichloro-7-hydroxy-1H-inden-1-one derivatives of the formula I ##STR1## wherein R.sub.1 is hydrogen or one of the groups ##STR2## R.sub.2 and R.sub.3 independently of one another are each hydrogen, fluorine, chlorine, bromine, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl or nitro,R.sub.4 is hydrogen, C.sub.1 -C.sub.6 -alkyl or C.sub.2 -C.sub.4 -alkenyl, each of which is unsubstituted or substituted by halogen, or R.sub.4 is phenyl which is unsubstituted or is substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, halogen, trifluoromethyl, cyano or nitro, or it is a C.sub.3 -C.sub.6 -cycloalkyl group, andR.sub.5 is C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl or C.sub.2 -C.sub.4 -alkenyl.These compounds exhibit a microbicidal action against in particular phytopathogenic fungi and bacteria.
    Type: Grant
    Filed: October 31, 1979
    Date of Patent: September 22, 1981
    Assignee: Ciba-Geigy Corporation
    Inventors: Elmar Sturm, Robert Nyfeler
  • Patent number: 4291050
    Abstract: This invention relates to a new class of chemical compounds which can be described generally as 6,7-disubstituted-2 or 2,2-substituted-5-substituted-1-indanones. These compounds are effective diuretic and saluretic agents.
    Type: Grant
    Filed: June 21, 1979
    Date of Patent: September 22, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Otto W. Woltersdorf, Jr., Edward J. Cragoe, Jr.
  • Patent number: 4290974
    Abstract: The invention relates to oxybenzylidenebornanones which correspond to the general formula: ##STR1## in which Z and Z' denote hydrogen or a radical SO.sub.3 H, at least one of the two radicals Z and Z' denoting hydrogen, R.sub.1 denotes hydrogen, an alkyl radical having 2 to 18 carbon atoms, an alkenyl radical having 3 to 18 carbon atoms, a radical --(CH.sub.2 CH.sub.2 O).sub.n H, ##STR2## --(CH.sub.2).sub.m CO.sub.2 R, in which R denotes H or an alkyl radical, --(CH.sub.2).sub.3 SO.sub.3 H or a divalent radical --(CH.sub.2).sub.m or --CH.sub.2 --CHOH--CH.sub.2, m having the values 1 to 10, n having the values 1 to 20 and p having the values 1 to 6, and R.sub.3 and R.sub.4 representing hydrogen or an optionally branched or hydroxylic alkyl radical, or forming an aminoaliphatic heterocyclic ring with the nitrogen atom, R.sub.2 denotes a hydrogen atom, an alkoxy radical or a divalent radical --O-- bonded to the radical R.sub.1 if the latter is also divalent, and q denotes 1 or 2; if q has the value 2, R.sub.
    Type: Grant
    Filed: July 10, 1979
    Date of Patent: September 22, 1981
    Assignee: L'Oreal
    Inventors: Claude Bouillon, Charles Vayssie
  • Patent number: 4285867
    Abstract: Compounds having the formula ##STR1## wherein ##STR2## R.sub.1 is hydrogen, benzyl or alkanoyl, X is C.sub.2-4 alkylene; andZ-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.
    Type: Grant
    Filed: September 19, 1980
    Date of Patent: August 25, 1981
    Assignee: Pfizer Inc.
    Inventors: Michael R. Johnson, Lawrence S. Melvin, Jr.
  • Patent number: 4284819
    Abstract: Processes and compositions are described for the use in foodstuff flavor and aroma, tobacco flavor and aroma and perfume and perfumed article aroma augmenting, modifying, altering and enhancing compositions and as foodstuff, chewing gum, toothpaste, medicinal product, tobacco, perfume and perfumed article aroma imparting materials of acetyl hydrindacenes and acetyl indanes and mixtures of same, said acetyl indanes and acetyl hydrindacenes having the structures: ##STR1## and existing in the liquid phase at ambient temperature and pressure.
    Type: Grant
    Filed: June 5, 1980
    Date of Patent: August 18, 1981
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mark A. Sprecker, Manfred H. Vock, Frederick L. Schmitt, Joaquin F. Vinals, Jacob Kiwala
  • Patent number: 4260511
    Abstract: Described for use in augmenting or enhancing the aroma of solid or liquid anionic, cationic or nonionic detergents are acetyl hydrindacenes and acetyl indanes and mixtures of same.
    Type: Grant
    Filed: June 5, 1980
    Date of Patent: April 7, 1981
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mark A. Sprecker, Manfred H. Vock, Frederick L. Schmitt, Joaquin Vinals, Jacob Kiwala
  • Patent number: 4231965
    Abstract: 2-Nitrobenzofurans in which the furan ring is either fused to or substituted by a fused bicyclic system, which are active as antimicrobial agents, processes for their use and intermediates therefor are described.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: November 4, 1980
    Assignee: Riker Laboratories, Inc.
    Inventors: Robert A. Scherrer, Richard M. Stern
  • Patent number: 4218472
    Abstract: New geminally disubstituted indenes are of general formula I ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or R.sup.1 and R.sup.2 together form a direct bond or an alkylene group --(CH.sub.2).sub.n --, in which n is an integer from 1 to 4, R.sup.3 is hydrogen, C.sub.1-3 -alkoxy or halogen, and each of R.sup.4 and R.sup.5 is hydrogen or C.sub.1-4 -lower alkyl, or R.sup.4 and R.sup.5 together form an alkylene group --(CH.sub.2).sub.m --, in which m is an integer from 3 to 6; and the corresponding amine oxides, quaternary ammonium compounds and salts with physiologically acceptable acids.The indenes find use in treating incontinence, as a mucous membrane decongestant, as a blood pressure reducing agent, as vasocostrictor or as an anti-reserpine agent.The indenes may be prepared by processes known per se involving(a) synthesing the side chain --CH(OH)CH.sub.2 NR.sup.4 R.sup.
    Type: Grant
    Filed: August 1, 1978
    Date of Patent: August 19, 1980
    Assignee: AB Kabi
    Inventors: Aake N. Joensson, Tomas G. Kempe, Lembit Mikiver, Bengt A. Sparf
  • Patent number: 4209543
    Abstract: Processes and compositions are described for the use in foodstuff flavor and aroma, tobacco flavor and aroma and perfume and perfumed article aroma augmenting, modifying, altering and enhancing compositions and as foodstuff, chewing gum, toothpaste, medicinal product, tobacco, perfume and perfumed article aroma imparting materials of acetyl hydrindacenes and acetyl indanes and mixtures of same, said acetyl indanes and acetyl hydrindacenes having the structures: ##STR1## and existing in the liquid phase at ambient temperature and pressure.
    Type: Grant
    Filed: October 20, 1978
    Date of Patent: June 24, 1980
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Mark A. Sprecker, Manfred H. Vock, Frederick L. Schmitt, Joaquin Vinals, Jacob Kiwala
  • Patent number: 4208351
    Abstract: An optically active 4-(4-substituted-2,6-dihydroxyphenyl)-6,6-dimethyl-2-norpinanone is reacted with a protonic acid to provide an optical isomer of a cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibe nzo[b,d]pyran-9-one. Reaction of said norpinanone with a Lewis acid provides an optical isomer of trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-di benzo[b,d]pyran-9-one. The optically active norpinanones are prepared by reaction of a 5-substituted-resorcinol with an optically active 6,6-dimethyl-2,4-diacetoxy-2-norpinene or an optically active 6,6-dimethyl-2,2-diacetoxy-3-norpinene, which compounds are derived from optically active .beta.-pinenes.
    Type: Grant
    Filed: April 17, 1979
    Date of Patent: June 17, 1980
    Assignee: Eli Lilly and Company
    Inventors: Robert A. Archer, William A. Day
  • Patent number: 4206230
    Abstract: There are provided insecticidal ketones having the general structure ##STR1## insecticidal compositions containing the ketones and a carrier, and the method of controlling insects with the ketones.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: June 3, 1980
    Assignee: Mobil Oil Corporation
    Inventor: Jill H. Paul
  • Patent number: 4201869
    Abstract: A multi-step, stereospecific total synthesis of steroids is disclosed. The starting materials for this process are the relatively inexpensive and readily available m-alkoxy acetophenones. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly A-ring aromatic steroids. This process features an early optical resolution and a unique asymmetric induction which insures the correct stereochemistry of the final steroidal product.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: May 6, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Noal Cohen, Gabriel Saucy