Alicyclic Ring Containing Patents (Class 568/329)
  • Patent number: 9593069
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: March 14, 2017
    Assignees: Northwestern University, Cambria Pharmaceuticals, Inc.
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Patent number: 9593063
    Abstract: The present invention relates to a method for producing photocleavable scent precursors, to products containing the scent precursors, and to the use of the scent precursors for prolonging the scent impression in the product and on surfaces treated with the product.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: March 14, 2017
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thomas Gerke, Christian Kropf, Ursula Huchel, Axel Griesbeck, Bjoern Porschen
  • Patent number: 9562025
    Abstract: The present invention relates to compounds having at least one (substituted phenyl)-propenal moiety. The compounds are useful in treating a subject suffering from an androgen receptor-associated medical condition, e.g., inflammation, acne, alopecia, hirsutism, wound, Spinal and Bulbar Muscular Atrophy (SBMA, Kennedy's Disease), unwanted immune response, immune disorder, or cancer.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: February 7, 2017
    Assignee: Allianz Pharmascience Ltd.
    Inventors: Charles Shih, Qian Shi, Hui-Kang Wang
  • Patent number: 9493717
    Abstract: A method to generate cyclic hydrocarbons from farnesene to increase both the density and net heat of combustion of the product fuels. The high density hydrocarbons produced by this method have applications for missile, UAV, jet, and diesel propulsion.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: November 15, 2016
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventor: Benjamin G. Harvey
  • Patent number: 9312041
    Abstract: Fragrances having a fresh character are usually very volatile and therefore not very economical in typical applications such as washing or cleaning processes for example. For that reason they have to be used in relatively large amounts in order to bring about appropriate effects. The present invention describes photolabile pro-fragrances of formula (I) that allow for a greatly improved persistence of the fragrance impression, in particular one having a fresh character, in typical applications. Said pro-fragrances attach very readily to target substrates, such as textiles for example. A more economical use of the fragrances in question can be ensured in this way.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: April 12, 2016
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thomas Gerke, Christian Kropf, Ursula Huchel, Axel Griesbeck, Olga Mayer
  • Patent number: 9162968
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: October 20, 2015
    Assignees: Northwestern University, Cambria Pharmaceuticals, Inc.
    Inventors: Donald Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Patent number: 9000222
    Abstract: The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: April 7, 2015
    Assignee: Androscience Corporation
    Inventors: Charles Shih, Qian Shi, Hui-Kang Wang
  • Publication number: 20150094474
    Abstract: The present invention relates to derivatives of compounds which are known to be of use in the field of agriculture. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more changes one or more of which may be considered to represent a change of oxidation state relative to the groups in the original compound. We refer to these compounds generally as redox derivatives. The compounds are of use as insecticides, herbicides and insect repellents.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 2, 2015
    Inventors: William Thompson, Peter Jackson, Derek Lindsay, Thomas Screen, Benjamin Moulton, Christopher Urch
  • Publication number: 20140378305
    Abstract: Compounds of formula wherein the substituents are as defined in claim 1, and related compositions, methods of use and processes of preparation.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Applicant: SYNGENTA LIMITED
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20140371313
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Application
    Filed: May 12, 2014
    Publication date: December 18, 2014
    Inventors: Donald Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Patent number: 8865623
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: October 21, 2014
    Assignee: Syngenta Limited
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20140308195
    Abstract: The present invention provides the compound [6]-cycloparaphenylene, cycloparaphenylene intermediates (e.g. [n]macrocycles), and methods for making [n]cycloparaphenylenes and [n]cycloparaphenylene intermediates in quantities not previously available. The cycloparaphenylene compounds and their intermediates can be useful in nanotube preparation and in the preparation of other supramolecular structures.
    Type: Application
    Filed: January 23, 2013
    Publication date: October 16, 2014
    Inventors: Ramesh Jasti, Jianlong Xia
  • Publication number: 20140228219
    Abstract: The present invention provides a compound having an excellent efficacy for controlling weeds. A cyclohexanone compound of the formula (I): wherein m is an integer of 1, 2 or 3; n is an integer of any one of 1 to 5; X represents CH2, O, S, S(O) or S(O)2; R1 represents a hydrogen atom or a methyl group; R2 and R3 represents a hydrogen atom, a C1-6 alkyl group and the like; R4 represents a C6-10 aryl group or a five- to six-membered heteroaryl group; G represents a hydrogen atom and the like; Z represents a halogen atom, a cyano group, a nitro group, a phenyl group, a C1-6 alkyl group and the like; is useful as an active ingredient for herbicides.
    Type: Application
    Filed: May 29, 2012
    Publication date: August 14, 2014
    Inventors: Yosuke Nakashima, Yoshinobu Jin, Masato Konobe
  • Publication number: 20140221632
    Abstract: The present invention disclosed a preparation method of parylene AF4, which provides a reactant and a reducing agent with the use of catalyst or exposure to UV light with photo-initiator, to shorten the reaction time as a result of minimized the byproduct(s) formation, and obtain high purity (>99.0%) of parylene AF4 product under high concentrated reaction mixture.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Inventors: Chun-Hsu LIN, Chian-Yi SUN, Yung-Yu YIN, Chun-Shih LI, Yo-Chun CHOU
  • Patent number: 8779206
    Abstract: The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: July 15, 2014
    Assignee: Innovative Surface Technologies, LLC
    Inventors: Patrick E. Guire, Kristin Taton, Jie Wen
  • Publication number: 20140135374
    Abstract: Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
    Type: Application
    Filed: June 13, 2012
    Publication date: May 15, 2014
    Applicant: BIKAM PHARMACEUTICALS, INC.
    Inventor: David S. Garvey
  • Patent number: 8722939
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: May 13, 2014
    Assignees: Northwestern University, Cambria Pharmaceuticals, Inc.
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Patent number: 8710272
    Abstract: The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: April 29, 2014
    Assignee: Androscience Corporation
    Inventors: Charles C. Y. Shih, Qian Shi, Hui-Kang Wang, Ching-Yuan Su
  • Publication number: 20140113849
    Abstract: Fragrances having a fresh character are usually very volatile and therefore not very economical in typical applications such as washing or cleaning processes for example. For that reason they have to be used in relatively large amounts in order to bring about appropriate effects. The present invention describes photolabile pro-fragrances that allow for a greatly improved persistence of the fragrance impression, in particular one having a fresh character, in typical applications. A more economical use of the fragrances in question can be ensured in this way.
    Type: Application
    Filed: December 26, 2013
    Publication date: April 24, 2014
    Applicant: Henkel AG & Co., KGaA
    Inventors: Thomas Gerke, Christian Kropf, Ursula Huchel, Axel Griesbeck, Olga Hinze
  • Patent number: 8673818
    Abstract: The present invention relates to novel C2-phenyl-substituted cyclic ketoenols of the formula in which W is methyl, X is alkyl, alkenyl or alkinyl, Y is hydrogen, methyl, ethyl, i-propyl, alkenyl or alkinyl, and Z is hydrogen, alkyl, alkenyl or alkinyl, with the proviso that at least one of X, Y, or Z represents a chain having at least two carbon atoms and with the further proviso that X is not ethyl when Z is hydrogen and Y is methyl, and CKE represents the group in which B is hydrogen, alkyl or alkoxyalkyl, A and Q1 together are optionally substituted alkanediyl or alkenediyl, Q2 is represents hydrogen or C1-C4-alkyl, and G represents hydrogen or an acyl or acyl-like group, to a plurality of processes for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: March 18, 2014
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Ruther, Hermann Hagemann, Udo Schneider, Markus Dollinger, Peter Dahmen, Ulrike Wachendorff-Neumann, Reiner Fischer, Alan Graff, Thomas Bretschneider, Christoph Erdelen, Mark Wilhelm Drewes, Dieter Feucht, Folker Lieb
  • Publication number: 20140011986
    Abstract: The present invention disclosed a preparation method of parylene AF4, which provides a reactant and a reducing agent with the use of catalyst or exposure to UV light with photo-initiator, to shorten the reaction time as a result of minimized the byproduct(s) formation, and obtain high purity (>99.0%) of parylene AF4 product under high concentrated reaction mixture.
    Type: Application
    Filed: September 21, 2012
    Publication date: January 9, 2014
    Inventors: Chun-Hsu LIN, Chien-Yi SUN, Yung-Yu YIN, Chun-Shih LI, Yo-Chun CHOU
  • Publication number: 20130344182
    Abstract: The present invention relates to the novel use of panduratin derivatives or an extract of Boesenbergia pandurata for enhancing muscle mass growth, fighting fatigue and enhancing exercise performance. A panduratin derivative or a salt thereof or an extract of Boesenbergia pandurata of the present invention may be used without side effect and has the effect of increasing the expression of PPAR-? in muscles to increase muscle mass, promoting recovery from fatigue and increase mobility, thereby improving exercise performance.
    Type: Application
    Filed: November 20, 2012
    Publication date: December 26, 2013
    Applicants: NEWTREE CO., LTD., BIOCARE CO., LTD.
    Inventors: Biocare Co., Ltd., Newtree Co., Ltd.
  • Patent number: 8604250
    Abstract: Scents having a fresh odor are usually very volatile, and therefore have a low yield in typical applications such as washing or cleaning processes. They must therefore be used in relatively large quantities so that commensurate effects can be achieved. The invention describes specific ketones as photolabile scent storage substances which enable greatly improved persistence of the scent impression, in particular with a fresh odor, in typical applications. Corresponding washing or cleaning agents and air freshening agents, and a method for scenting surfaces, are also described.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: December 10, 2013
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thomas Gerke, Christian Kropf, Ursula Huchel, Axel Griesbeck, Olga Hinze
  • Publication number: 20130306909
    Abstract: To provide a liquid crystal compound having a large negative value of dielectric anisotropy (??). A compound is represented by formula (1): wherein, in formula (1), R1 and R2 are hydrogen, halogen or alkyl having 1 to 10 carbons, and in the alkyl, at least one of —CH2— may be replaced by —O—, at least one of —(CH2)2— may be replaced by —CH?CH—, and at least one of hydrogen may be replaced by halogen; ring A1 and ring A2 are 1,4-cyclohexylene or 1,4-phenylene; Z1 is a single bond, —(CH2)2—, —CH2O—, —OCH2—, —CF2O—, —OCF2—, —COO—, or —OCO—; Y is halogen, —CF3, —CF2H or —CH2F; and m, n and p are 0, 1 or 2, and a sum (m+n) of m and n is 0, 1 or 2.
    Type: Application
    Filed: May 17, 2013
    Publication date: November 21, 2013
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Mayumi GOTO, Yasuyuki SASADA
  • Publication number: 20130289128
    Abstract: The invention provides a compound of formula (I): or a salt thereof, wherein R1-R5 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as RNA polymerase inhibitors and antibacterial agents.
    Type: Application
    Filed: September 7, 2011
    Publication date: October 31, 2013
    Inventors: Richard H. Ebright, Juan Shen
  • Publication number: 20130261121
    Abstract: The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.
    Type: Application
    Filed: June 18, 2012
    Publication date: October 3, 2013
    Inventors: Charles C.Y. SHIH, Qian Shi, Hui-Kang Wang, Ching-Yuan Su
  • Patent number: 8496857
    Abstract: The invention describes novel compositions that include a cross linking compound, a polymer and a 1 nm to about a 25 micron sized particle optionally with an oxide layer. In particular, the particle is a silica and one which has been pretreated with a silane.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: July 30, 2013
    Assignee: Innovative Surface Technologies, Inc.
    Inventors: Patrick E. Guire, Kristin Taton, Jie Wen, Laurie R. Lawin
  • Patent number: 8487137
    Abstract: The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.
    Type: Grant
    Filed: July 7, 2010
    Date of Patent: July 16, 2013
    Assignee: Innovative Surface Technologies, LLC
    Inventors: Patrick E. Guire, Kristin Taton, Jie Wen
  • Publication number: 20130177515
    Abstract: The present invention relates to new monoterpene derivatives of chalcone or dihydrochalcone and their use as a depigmenting agent.
    Type: Application
    Filed: January 18, 2012
    Publication date: July 11, 2013
    Applicant: PIERRE FABRE DERMO-COSMETIQUE
    Inventors: Anne Mandeau, Stéphane Poigny, Françoise Belaubre
  • Patent number: 8470889
    Abstract: The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesized and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: June 25, 2013
    Assignee: TRT Pharma Inc.
    Inventors: Jian Hui Wu, Gérald Batist, Jinming Zhou, Guoyan Geng, Rongtuan Lin, Yi Li
  • Patent number: 8455537
    Abstract: A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount of a compound of formula I, II, or a combination thereof: wherein R1, R3, R4, and R5 are independently selected from H, OH, and ORa; R2 is selected from H, OH, and (C?O) (C1-7)alkyl; Ra is (C1-7)alkyl or (C?O)(C1-7)alkyl; or a derivative of the compound selected from N-oxide derivatives, prodrug derivatives, protected derivatives, isomers, and mixtures of isomers of the compound; or a pharmaceutically acceptable salt or solvate of the compound or the derivative. Compounds of formula I and II and pharmaceuticals compositions thereof are also presented.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: June 4, 2013
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: William J. Welsh, Ching Y. Wang, Ni Ai
  • Patent number: 8449954
    Abstract: The present invention relates to a specific photoreactive polymer that shows excellent alignment stability and thermal stability together with excellent liquid crystal alignment, thereby being desirably used in an alignment film of a liquid crystal display device, a compound having a photoreactive functional group that is used as a monomer for the preparation of the photoreactive polymer, and an alignment film.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: May 28, 2013
    Assignee: LG Chem, Ltd.
    Inventors: Dai-Seung Choi, Sung-Ho Chun, Young-Chul Won, Dong-Woo Yoo
  • Publication number: 20130096175
    Abstract: Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.
    Type: Application
    Filed: November 17, 2010
    Publication date: April 18, 2013
    Applicants: SOUTHERN RESEARCH INSTITUTE, UNIVERSITY OF ROCHESTER
    Inventors: David S. Goldfarb, Joseph A. Maddry, Lynn Rasmussen, Ellie Lucile White, Krister Wennerberg
  • Publication number: 20120315403
    Abstract: Scents having a fresh odor are usually very volatile, and therefore have a low yield in typical applications such as washing or cleaning processes. They must therefore be used in relatively large quantities so that commensurate effects can be achieved. The invention describes specific ketones as photolabile scent storage substances which enable greatly improved persistence of the scent impression, in particular with a fresh odor, in typical applications. Corresponding washing or cleaning agents and air freshening agents, and a method for scenting surfaces, are also described.
    Type: Application
    Filed: August 14, 2012
    Publication date: December 13, 2012
    Applicant: Henkel AG & Co. KGaA
    Inventors: Thomas Gerke, Christian Kropf, Ursula Huchel, Axel Griesbeck, Olga Hinze
  • Publication number: 20120264765
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Application
    Filed: October 29, 2010
    Publication date: October 18, 2012
    Applicants: Cambria Pharmaceuticals, Inc., Northwestern University
    Inventors: Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanties, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Patent number: 8277903
    Abstract: The present disclosure relates to methods and systems for synthesis of bridged-hydropentacene, hydroanthracene and hydrotetracene from the precursor compounds pentacene derivatives, tetracene derivatives, and anthracene derivatives. The invention further relates to are methods and systems for forming thin films for use in electrically conductive assemblies, such as semiconductors or photovoltaic devices.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: October 2, 2012
    Assignee: Academia Sinica
    Inventors: Tahsin J. Chow, Chung-Chih Wu, Ta-Hsien Chuang, Hsing-Hung Hsieh, Hsin-Hui Huang
  • Publication number: 20120202066
    Abstract: Disclosed are improved processes for preparing prasugrel compound of formula-(1), its intermediates and pharmaceutically acceptable salts.
    Type: Application
    Filed: October 7, 2010
    Publication date: August 9, 2012
    Inventors: Manne Satyanarayana Reddy, Srinivasan Thirumalai Rajan, Sajja Eswaraiah, Karamala Rama Subba Reddy, Bairy Kondal Reddy, Ghojala Venkat Reddy
  • Publication number: 20120190545
    Abstract: Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Application
    Filed: July 17, 2009
    Publication date: July 26, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John Mathews, James Nicholas Scutt
  • Patent number: 8193120
    Abstract: The present invention relates to novel C2-phenyl-substituted cyclic ketoenols, to a plurality of processes for their preparation and to their use as pesticides as herbicides.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: June 5, 2012
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Ruther, Hermann Hagemann, Udo Schneider, Markus Dollinger, Peter Dahmen, Ulrike Wachendorff-Neumann, Reiner Fischer, Alan Graff, Thomas Bretschneider, Christophe Erdelen, Mark Wilhelm Drewes, Dieter Feucht, Folker Lieb
  • Patent number: 8187346
    Abstract: A method for stabilizing pyrolysis gasoline in storage involves adding an effective amount of a quinone methide compound to the pyrolysis gasoline. The quinone methide does not require oxygen for activity. Embodiments of the quinone methide do not contain nitrogen and will have a reduced tendency for ammonia production.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: May 29, 2012
    Assignee: Fina Technology, Inc.
    Inventor: James R. Butler
  • Patent number: 8168832
    Abstract: The invention relates to novel 2,4,6-trialkylphenyl-substituted cyclopentane-1,3-diones of the formula (I) in which X, Y, A, B, Q1, Q2 and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising, firstly, the 2,4,6-trialkylphenyl-substituted cyclopentane-1,3-diones of the formula (I) and, secondly, at least one crop plant compatibility-improving compound.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: May 1, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Reiner Fischer, Stefan Lehr, Dieter Feucht, Ulrich Görgens, Olga Malsam, Alfred Angermann, Guido Bojack, Alan Graff, Christian Arnold, Thomas Auler, Martin Jeffrey Hills, Heinz Kehne, Christopher Hugh Rosinger, Jan Dittgen
  • Publication number: 20120088840
    Abstract: The present invention relates to a novel use of a panduratin derivative or a Boesenbergia pandurata extract. More specifically, the invention relates to a composition for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, containing a panduratin derivative represented by Chemical Formula 1, 2 or 3 or a Boesenbergia pandurata extract as an active ingredient, a method for treating a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, by administering an effective amount of the panduratin derivative or the Boesenbergia pandurata extract to a subject in need thereof, and a use of the panduratin derivative or the Boesenbergia pandurata extract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes.
    Type: Application
    Filed: October 9, 2009
    Publication date: April 12, 2012
    Applicants: JAE-KWAN HWANG, NEWTREE CO., LTD.
    Inventors: Jae-Kwan Hwang, Do Un Kim
  • Publication number: 20120071465
    Abstract: The present invention relates to the compounds useful in the prevention and/or treatment of tumours. More specifically the present invention relates to inhibitors of the activity of the electron transport chains and/or the mitochondrial TCA cycle in glioma-initiating cells (GICs) for use in a method for preventing and/or treating tumours presenting glioma-initiating cells (GICs) in a subject who has undergone a prior removal of a tumour glioma bulk. The present invention further provides a pharmaceutical composition containing the inhibitors of the invention and a screening method for identifying the inhibitors of the invention.
    Type: Application
    Filed: May 20, 2010
    Publication date: March 22, 2012
    Inventors: Virginie Clement, Ivan Radovanovic
  • Publication number: 20120065272
    Abstract: The present invention relates to a new use of panduratin derivatives or a Kaempferia pandurata extract comprising the same. More particularly, the present invention relates to a composition for improving wrinkles and/or preventing aging, which comprises a panduratin derivative or a Kaempferia pandurata extract comprising the same. The said the panduratin derivative or the Kaempferia pandurata extract comprising the same induces cell proliferation, inhibits degradation of collagen, and promotes synthesis of collagen, therefore, it shows excellent activity in prevention of aging, particularly preventing, improving or treating wrinkle and it can be used as an effective ingredient in a cosmetic, food or pharmaceutical composition.
    Type: Application
    Filed: October 17, 2008
    Publication date: March 15, 2012
    Applicant: NEWTREE CO., LTD.
    Inventors: Jae Kwan Hwang, Jae-Seok Shim, Song Hui Gwon, Yi Young Kwon, Hyun In Oh, Young Sun Han, Eun Jung Choi, Do Un Kim
  • Publication number: 20120053208
    Abstract: Curcumin analogues and methods of making and using the same are disclosed.
    Type: Application
    Filed: April 15, 2010
    Publication date: March 1, 2012
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Pui-Kai Li, Chenglong Li, Jiayuh Lin, James R. Fuchs
  • Publication number: 20120021907
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Application
    Filed: January 6, 2010
    Publication date: January 26, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John Mathews, John Finney, James Nicholas Scutt, Louisa Robinson, John Stephen Delaney
  • Publication number: 20110319465
    Abstract: A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount of a compound of formula I, II, or a combination thereof: wherein R1, R3, R4, and R5 are independently selected from H, OH, and ORa; R2 is selected from H, OH, and (C?O) (C1-7)alkyl; Ra is (C1-7)alkyl or (C?O)(C1-7)alkyl; or a derivative of the compound selected from N-oxide derivatives, prodrug derivatives, protected derivatives, isomers, and mixtures of isomers of the compound; or a pharmaceutically acceptable salt or solvate of the compound or the derivative. Compounds of formula I and II and pharmaceuticals compositions thereof are also presented.
    Type: Application
    Filed: June 21, 2011
    Publication date: December 29, 2011
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: William Welsh, Ching Y. Wang, Ni Ai
  • Patent number: 8026220
    Abstract: Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: September 27, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Margaret Clagett-Dame, Robert W. Curley, Jr., Joel R. Walker, Hussein Abou-Issa, Galal A. Alshafie
  • Publication number: 20110230488
    Abstract: The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesised and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.
    Type: Application
    Filed: November 25, 2009
    Publication date: September 22, 2011
    Applicant: TRT PHARMA INC.
    Inventors: Jian Hui Wu, Gerald Batist, Jinming Zhou, Guoyan Geng, Rongtuan Lin
  • Publication number: 20110212906
    Abstract: Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.
    Type: Application
    Filed: May 12, 2011
    Publication date: September 1, 2011
    Inventors: Margaret Clagett-Dame, Robert W. Curley, JR., Joel R. Walker, Hussein Abou-Issa, Galal A. Alshafie