Alicyclic Ring Containing Patents (Class 568/329)
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Publication number: 20110212906Abstract: Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.Type: ApplicationFiled: May 12, 2011Publication date: September 1, 2011Inventors: Margaret Clagett-Dame, Robert W. Curley, JR., Joel R. Walker, Hussein Abou-Issa, Galal A. Alshafie
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Publication number: 20100298579Abstract: The field of the invention is organic synthesis, more particularly a process for preparing cannabinoids. The process described is applicable to all stereoisomers and homologues of cannabinoids. For this purpose, the present patent application provides a process for preparing the abovementioned compounds in two or three chemical synthesis steps.Type: ApplicationFiled: April 29, 2010Publication date: November 25, 2010Applicant: THC PHARM GMBHInventors: CHRISTIAN STEUP, THOMAS HERKENROTH
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Patent number: 7820865Abstract: The instant invention relates to new photolatent compounds of the formula I wherein R1 and R2 are each independently of the other C1-C10alkyl or C3-C8cycloalkyl, R3 is hydrogen or C1-C4alkyl, and wherein the photochemically cleaved group R4OH is selected from the group consisting of fragrances, UV absorbers, anti-microbials, anti-fogging agents and clarifiers; with the proviso that, when R1 and R2 are tert-butyl and R3 is hydrogen, R4 is not methyl or phenyl.Type: GrantFiled: October 30, 2006Date of Patent: October 26, 2010Assignee: Ciba CorporationInventors: Katharina Fritzsche, Walter Fischer, Johannes Benkhoff, Karin Powell, Dirk Simon
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Patent number: 7799954Abstract: Derivatives of dicarbonyl compounds having antitumor and antibiotic activity which can be used as anticancer agents.Type: GrantFiled: November 14, 2007Date of Patent: September 21, 2010Assignee: Abraxis BioScience, LLCInventors: Chunlin Tao, Qinwei Wang, Vuong Trieu, Neil Desai, Patrick Soon-Shiong
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Publication number: 20100162617Abstract: A method for stabilizing pyrolysis gasoline in storage involves adding an effective amount of a quinone methide compound to the pyrolysis gasoline. The quinone methide does not require oxygen for activity. Embodiments of the quinone methide do not contain nitrogen and will have a reduced tendency for ammonia production.Type: ApplicationFiled: December 29, 2008Publication date: July 1, 2010Applicant: Fina Technology, Inc.Inventor: James R. Butler
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Publication number: 20100152271Abstract: A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount of a compound of formula I, II, or a combination thereof: wherein R1, R3, R4, and R5 are independently selected from H, OH, and ORa; R2 is selected from H, OH, and (C?O)(C1-7)alkyl; Ra is (C1-7)alkyl or (C?O)(C1-7)alkyl; or a derivative of the compound selected from N-oxide derivatives, prodrug derivatives, protected derivatives, isomers, and mixtures of isomers of the compound; or a pharmaceutically acceptable salt or solvate of the compound or the derivative. Compounds of formula I and II and pharmaceuticals compositions thereof are also presented.Type: ApplicationFiled: July 6, 2007Publication date: June 17, 2010Applicant: UNIVERSIT OF MEDICINE AND DENISTRY OF NEW JERSEYInventors: William J. Welsh, Nina Ching Y. Wang, Ni Ai
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Publication number: 20100136459Abstract: The present invention provides, as an electrolyte which is useful as a material for a proton conductive membrane in a solid polymer fuel cell utilizing a gas fuel such as hydrogen gas or a liquid fuel such as methanol or dimethyl ether and which has higher proton conductivity than the conventional electrolytes do, an electrolyte characterized by containing an oxocarbon molecule, wherein the oxocarbon molecule has a difference in heat of formation ?E defined as: ?E=E2?E1 (kcal/mol) satisfying the range of: ?E<?70 (kcal/mol), wherein E1 (kcal/mol) is a heat of formation in the state where a hydrogen ion is non-dissociated, and E2 (kcal/mol) is a heat of formation in the state where a hydrogen having the lowest dissociation energy in the molecule ion is dissociated, both being calculated in regard to the stabilized molecular structure in accordance with a molecular orbital method.Type: ApplicationFiled: June 19, 2006Publication date: June 3, 2010Applicant: Sumitomo Chemical Company, LimitedInventors: Ken Yoshimura, Masamitsu Ishitobi
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Publication number: 20100121062Abstract: A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1—B-T ??(I); where R1 represents an organic group, T represents a conformationally rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a palladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.Type: ApplicationFiled: September 25, 2009Publication date: May 13, 2010Applicant: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, David M. Knapp, Eric P. Gillis
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Patent number: 7700808Abstract: There is provided a novel process intermediate represented by the general formula (1) or (2): (where, X represents halogen atom, cyano group or the like, Y represents halogen atom, cyano group or the like, R1 represents C1-C6 haloalkyl group or C3-C8 halocycloalkyl group, R2 represents methyl group, halogen atom, cyano group or the like, m represents an integer of 1 to 5, and n represents an integer of 1 to 4).Type: GrantFiled: December 25, 2006Date of Patent: April 20, 2010Assignee: Nissan Chemical Industries, Ltd.Inventors: Takashi Mizukoshi, Yasuhiro Sakurai, Kazutaka Matoba, Manabu Yaosaka
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Publication number: 20100048887Abstract: This invention provides novel compounds comprising the following anti-inflammatory pharmacore: wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.Type: ApplicationFiled: April 20, 2009Publication date: February 25, 2010Inventors: Eric Anderson, Gary L. Bolton, Deborah A. Ferguson, Xin Jiang, Robert M. Kral, JR., Patrick M. O'Brien, Melean Visnick
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Patent number: 7589123Abstract: Compounds of general formula I: wherein: R1 and R2 are, independently of each other, selected from hydrogen, optionally substituted C1-10alkyl, optionally substituted —CO—(C1-10alkyl), optionally substituted C3-10cycloalkyl, optionally substituted —CO—(C3-10cycloalkyl), optionally substituted C2-10alkenyl, optionally substituted —CO—(C2-10alkenyl), optionally substituted aryl, and optionally substituted —CO-aryl, or R1 and R2 together represent an optionally substituted saturated or unsaturated C1-10alkylidene group, or an optionally substituted saturated or unsaturated C3-10cycloalkylidene group, or R1 and R2 together with the carbon atom to which they are attached represent an optionally substituted saturated or unsaturated organic ring containing 3, 4, 5, 6, 7 or 8 ring carbon atoms and optionally 1, 2 or 3 ring heteroatoms selected from O, N and S; R3, which may be the same as, or different from, either of R1 and R2, is selected from optionally substituted C1-10alkyl, optionally substituted C3-10cyclType: GrantFiled: July 5, 2007Date of Patent: September 15, 2009Assignee: Phytopharm PLCInventors: Daryl David Rees, Phillip James Gunning, Antonia Orsi, Patrick A. Howson, Paul Barraclough, Noelle Callizot
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Publication number: 20090162307Abstract: The instant invention relates to new photolatent compounds of the formula I wherein R1 and R2 are each independently of the other C1-C10alkyl or C3-C8cycloalkyl, R3 is hydrogen or C1-C4alkyl, and wherein the photochemically cleaved group R4OH is selected from the group consisting of fragrances, UV absorbers, anti-microbials, anti-fogging agents and clarifiers; with the proviso that, when R1 and R2 are tert-butyl and R3 is hydrogen, R4 is not methyl or phenyl.Type: ApplicationFiled: October 30, 2006Publication date: June 25, 2009Inventors: Katharina Fritzsche, Walter Fischer, Johannes Benkhoff, Karin Powell, Dirk Simon
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Patent number: 7528114Abstract: Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.Type: GrantFiled: May 3, 2006Date of Patent: May 5, 2009Assignee: Wisconsin Alumni Research FoundationInventors: Margaret Clagett-Dame, Robert W. Curley, Jr., Joel R. Walker, Hussein Abou-Issa, Galal A. Alshafie
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Publication number: 20090087916Abstract: The present invention provides a method of identifying a drug candidate capable of removing peptide, oligopeptide, polypeptide or protein from fibril or aggregate, which includes measuring, in the presence of a test compound, the concentration of a soluble peptide, a soluble oligopeptide, a soluble polypeptide or a soluble protein in an equilibrium state in a solvent. Moreover, the present invention provides a dissolution promoter to remove peptide, oligopeptide, polypeptide or protein from fibril or aggregate, which contains the compound obtained by the identification method as an active ingredient.Type: ApplicationFiled: March 30, 2005Publication date: April 2, 2009Applicant: AnGesMG, Inc.Inventors: Naoyuki Sato, Masayasu Okochi, Yoshiaki Taniyama, Toshio Ogihara, Ryuichi Morishita
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Publication number: 20090023923Abstract: There is provided a novel process intermediate represented by the general formula (1) or (2): (where, X represents halogen atom, cyano group or the like, Y represents halogen atom, cyano group or the like, R1 represents C1-C6 haloalkyl group or C3-C8 halocycloalkyl group, R2 represents methyl group, halogen atom, cyano group or the like, m represents an integer of 1 to 5, and n represents an integer of 1 to 4).Type: ApplicationFiled: December 25, 2006Publication date: January 22, 2009Applicant: NISSAN CHEMICAL INDUSTRIES, LTDInventors: Takashi Mizukoshi, Yasuhiro Sakurai, Kazutaka Matoba, Manabu Yaosaka
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Publication number: 20080306165Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, poly-cystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed.Type: ApplicationFiled: January 22, 2007Publication date: December 11, 2008Applicant: WELLSTAT THERAPEUTICS CORPORATIONInventors: Shalini Sharma, Reid W. von Borstel
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Patent number: 7432225Abstract: The present invention relates to selective herbicidal compositions comprising an effective amount of an active compound combination comprising (a) at least one substituted cyclic ketoenol of the formula (I) in which X, Z, W and Y and the group CKE are as defined in the disclosure, and (b) at least one compound which improves crop plant compatibility selected from the group of compounds listed in the description, particularly cloquintocet-mexyl and mefenpyr-diethyl. The invention further relates to the use of these compositions as herbicides and to a method for controlling undesirable vegetation using these compositions.Type: GrantFiled: July 29, 2002Date of Patent: October 7, 2008Assignee: Bayer CropScience AGInventors: Reiner Fischer, Mark Wilhelm Drewes, Dieter Feucht, Peter Dahmen, Rolf Pontzen
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Publication number: 20080221220Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 2?,4?-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds (collectively referred to herein as “DCBP compounds”), and more particularly to compounds selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, and hydrates thereof: wherein: n is independently 1, 2, 3, or 4; W is independently —C(?O)—, —CH(OH)—, or —C(?NOROX)—; ROX is independently —H or C1-3alkyl; J is independently: —H, —RE1, —C(?O)—RE2, —C(?O)—O—RE3, —C(?O)—O—S(?O)2ORE4, —C(?O)—(CH2)n—C(?O)ORE5, —C(?O)—(CH2)n—NRNE1RNE2, —C(?O)—(CH2)n—NRNE3—C(?O)RE6, —C(?O)—(CH2)n—C(?O)—NRNE4RNE5, or —P(?O)(ORE7)(ORE8); wherein each of RE1, RE2, RE3, RE4, RE5, RE6, and RE7 is independently: —H, C1-3alkyl, -Ph, or —CH2-Ph.Type: ApplicationFiled: March 6, 2008Publication date: September 11, 2008Inventors: Iain Robert Greig, Robert Jurgen van 't Hof, Stuart Hamilton Ralston
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Publication number: 20080206490Abstract: The present invention relates to cyclobutane and spiro[3.3]heptane compounds, to a process for the preparation thereof, to the use thereof as components in liquid-crystalline media, and to electro-optical display elements which contain these liquid-crystalline media.Type: ApplicationFiled: August 16, 2006Publication date: August 28, 2008Inventors: Volker Reiffenrath, Matthias Bremer, Melanie Klasen-Memmer
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Publication number: 20080146586Abstract: Derivatives of dicarbonyl compounds having antitumor and antibiotic activity which can be used as anticancer agents.Type: ApplicationFiled: November 14, 2007Publication date: June 19, 2008Applicant: Abraxis BioScienceInventors: Chunlin Tao, Qinwei Wang, Vuong Trieu, Neil Desai, Patrick Soon-Shiong
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Publication number: 20080125481Abstract: There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4); OH, and one of R1 and R2 is selected from H, OH and OCH3, and the other of R1 and R2 is selected from OH and OCH3; one of R3 and R4 is selected from H, OH and OCH3, and the other of R3 and R4 is selected from OH and OCH3; provided that at least one of the pairs R1, R2 and R3, R4 are both OH; R5 is selected from OH and OCH3; and denotes a single or double bond; and pharmaceutically acceptable salts and prodrugs thereof. The compounds of the invention are useful for the treatment of hormone-dependent conditions and cancers.Type: ApplicationFiled: January 31, 2008Publication date: May 29, 2008Inventor: George Eustace Joannou
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Publication number: 20080058412Abstract: The invention relates to substituted 1,3-diphenylprop-2-en-1-one derivative compounds, pharmaceutical and/or cosmetic compositions containing same, and the applications thereof in therapeutics and cosmetics. The invention also relates to a method for preparing said derivatives.Type: ApplicationFiled: January 7, 2005Publication date: March 6, 2008Applicant: GENFITInventors: Karine Caumont-Bertrand, Jean-Francois Delhomel
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Patent number: 7265248Abstract: A colchicine derivative and a method of using a colchicine derivative as a pharmacological agent in the treatment of malaria are provided.Type: GrantFiled: April 28, 2006Date of Patent: September 4, 2007Assignee: Technology Innovations, LLCInventors: Jack A. Tuszynski, Stephen H. Curry
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Patent number: 7227043Abstract: The invention relates to novel phenyl-substituted cyclopentane- and cyclohexane-1,3-dione derivatives of the formula (I) in which W, X, Y, Z, A, B, Q1, Q2, Q3, Q4, G and m are as defined in the disclosure, to processes and intermediates for their preparation and to their use as pesticides, microbicides and/or herbicides.Type: GrantFiled: October 9, 2003Date of Patent: June 5, 2007Assignee: Bayer CropScience AgInventors: Reiner Fischer, Stefan Hillebrand, Axel Trautwein, Astrid Ullmann, Mark Wilhelm Drewes, Dieter Feucht, Jörg Konze, Karl-Heinz Kuck, Ulrike Wachendorff-Neumann
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Patent number: 7179817Abstract: Compounds represented by formula (I), prodrugs thereof and salts thereof, and pharmaceutical compositions comprising the same as an active ingredient (wherein each symbol has the meaning as defined in the specification.).Type: GrantFiled: May 9, 2002Date of Patent: February 20, 2007Assignee: ONO Pharmaceutical Co., Ltd.Inventors: Takuya Seko, Masahiko Terakado, Hiroshi Kohno, Shinya Takahashi
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Patent number: 7022664Abstract: The invention relates to 1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones and to the use of these compounds in fragrance compositions.Type: GrantFiled: April 28, 2003Date of Patent: April 4, 2006Assignee: Givaudan SAInventor: Philip Kraft
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Patent number: 6949680Abstract: A compound of formula wherein Y represents a pyridyl group, or a phenyl group of formula wherein R3 represents a hydrogen atom, a CF3 group or an alkoxy group, R4 represents a hydrogen atom, an alkyl group, or a CF3 group, R5 represents a hydrogen atom, an alkyl group, a CF3 group or an alkoxy group, and R1 and R2 are the substituents of a terminal alkene of formula wherein R1 represents an alkyl or alkylene group, a mono- or poly-cycloalkyl group, or a phenyl group that optionally includes one or several hetero-atoms of oxygen, nitrogen, phosphorous or sulfur; R2 represents a hydrogen atom, an alkyl or alkylene group, a mono- or poly-cycloalkyl group, or a phenyl group that optionally includes one or several hetero-atoms of oxygen, nitrogen, phosphorous and sulfur.Type: GrantFiled: October 15, 2002Date of Patent: September 27, 2005Assignee: Firmenich SAInventor: Andreas Herrmann
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Patent number: 6949557Abstract: The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of hydroanthracene based compounds for the inhibition and/or prevention of cancer of the colon, pancreas, prostate, lung, larynx, ovary, breast, glioblastoma, oral cavity, endothelial cells and leukemias. The agents of the invention form a distinct class, distinct from the anthracene, anthrone or anthraquinone derivatives.Type: GrantFiled: April 29, 2003Date of Patent: September 27, 2005Assignee: Dabur Research FoundationInventors: Asish Kumar Banerjee, Venkatachalam Sesha Giri, Rama Mukherjee, Kamal K. Kapoor, Gautam Desiraju, Manu Jaggi, Anu T. Singh, Sankar Kumar Dutta, Kalapatapu V. V. M. Sairam
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Patent number: 6949585Abstract: The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is represented by the following general formula (I) [wherein A represents a cyclic group which may be substituted; the partial structure -DE- represents a group represented by —CH2CH2— or —CH?CH—; W represents a group represented by —CH2—, —CH2CH2—, —CH?CH— or —CH?; the partial structure >XY— represents a group represented by >CH—(CH2)n—, >C?CH—, >CH—CH2—CH(OH)—, >CH—CH2—C(?O)—, >CH—O— or >CH—O—CO—, provided that when W is —CH?, then XY— represents C—(CH2)p—; Z represents a divalent aliphatic hydrocarbon group; R1 and R2, which may be the same or different, each represents a hydrogen atom, or a hydroxyl, alkoxy or alkoxyalkoxy group; m is an integer of 0 or 1].Type: GrantFiled: April 1, 2002Date of Patent: September 27, 2005Assignee: Eisai Co., Ltd.Inventors: Yoshihito Eguchi, Ken-ichi Chiba, Masaki Goto, Hiroshi Obaishi, Yoshikazu Kuboi
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Patent number: 6939845Abstract: The present invention provides a fragrance precursor of formula I: that is capable of forming a fragrant ketone of formula II: and a fragrant lactone of formula III:Type: GrantFiled: June 18, 2001Date of Patent: September 6, 2005Assignee: Givaudan SAInventors: Markus Gautschi, Caroline Plessis, Samuel Derrer
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Patent number: 6906076Abstract: The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby blocking importation of specific proteins or molecular complex into the nucleus of a cell. The invention encompasses methods of use of such compounds for treatment or prevention of infectious diseases, such as parasitic and viral diseases, including, for example, malaria and acquired immunodeficiency syndrome. The use of the compounds to detect certain specific protein structures which are present in nuclear localization sequences is also taught.Type: GrantFiled: September 12, 2003Date of Patent: June 14, 2005Assignee: Cytokine Pharmasciences, Inc.Inventors: Michael I. Bukrinsky, Anthony Cerami, Peter Ulrich, Bradley Berger
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Patent number: 6887904Abstract: Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology.Type: GrantFiled: December 4, 2002Date of Patent: May 3, 2005Assignee: Aventis Pharma S. A.Inventors: Patrick Mailliet, Marc Capet, Gilles Tiraboschi, Thomas Caulfield
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Patent number: 6881865Abstract: Disclosed is a synthesis method of cyclohexyl phenyl ketone with a high selectivity and a high yield from 1,3-butadiene and acrylic acid in the presence or absence of benzene or a non-aromatic organic solvent in the same reaction without a step of separating or purifying intermediates, the synthesis method including sequentially carrying out a [2+4] Diels-Alder reaction, a hydrogenation reaction, a chlorination reaction and a Friedel-Crafts reaction in the presence/absence of benzene or a non-aromatic organic solvent without separation of intermediates.Type: GrantFiled: July 28, 2003Date of Patent: April 19, 2005Assignee: Korea Kumho Petrochemical Co., Ltd.Inventors: Young J. Joo, Jin Eok Kim, Jeong Im Won, Tae Yi Kang
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Publication number: 20040220236Abstract: The present invention pertains to compounds of the formula (I) which are, inter alia, antiprolilferative agents, anticancer agents, anitimycohacterial agents, antituberculosis agents, and/or thioredoxin/thioredoxin reductase inhibitor: wherein: Q is ═O or ═N—S(═O)2—RQ; RQ is -II or optionally substituted C1-7alkyl, C3-20heterocyclyl, or C5-20aryl; Ar is optionally substituted C5-20aryl; RO is an oxy substituent; the bond marked &agr; is a single bond or a double bond; the bond marked &bgr; is a single bond or a double bond; R3 and R5 are each independently ring substituents; R2 and R6 are each independently ring substituents; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for example, in the treatment of proliferative conditions, (e.g.Type: ApplicationFiled: April 27, 2004Publication date: November 4, 2004Inventors: Malcolm Francis Graham Stevens, Geoffrey Wells, Andrew David Westwell, Tracey Dawn Poole
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Patent number: 6774086Abstract: There are described derivatives of benzoylcyclohexanediones of the formula (I) and their use as herbicides. In this formula (I), R1a, R1b, R1c, R2, R3, R4 and R5 are various radicals, X1 is a bridging atom, X2 a carbon chain and X3 a chalcogen atom.Type: GrantFiled: September 10, 2002Date of Patent: August 10, 2004Assignee: Bayer CropScience GmbHInventors: Thomas Seitz, Lothar Willms, Andreas van Almsick, Hermann Bieringer, Thomas Auler, Hubert Menne
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Publication number: 20030229136Abstract: Novel compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones.Type: ApplicationFiled: April 18, 2002Publication date: December 11, 2003Inventors: Nurulain Zaveri, Wan-Ru Chao
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Patent number: 6642180Abstract: The present invention relates to novel biphenyl-substituted cyclic ketoenols of the formula (I) in which W represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, halogenoalkyl or halogenoalkoxy, CKE represents one of the groups in which A, B, D, L, M, Q1, Q2, Q3, Q4, Q5 and Q6 are as defined in the description, to preparation and to their use as pesticides and herbicides.Type: GrantFiled: January 25, 2002Date of Patent: November 4, 2003Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Alan Graff, Thomas Bretschneider, Christoph Erdelen, Mark Wilhelm Drewes, Dieter Feucht
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Patent number: 6642418Abstract: The invention relates to processes for the preparation of compounds of formula (I), wherein R1 and R2 are as defined in the description.Type: GrantFiled: December 4, 2000Date of Patent: November 4, 2003Assignee: Aventis Cropscience SAInventors: Susan Mary Cramp, Neil Jonathan Geach
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Patent number: 6617473Abstract: The invention relates to a preparation process for derivatives by catalytic dehydrogenation of dibenzosuberone derivatives.Type: GrantFiled: February 26, 2002Date of Patent: September 9, 2003Assignee: Haarman & Reimer GmbHInventors: Stefan Lambrecht, Horst Surburg
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Patent number: 6605639Abstract: It has been newly found out that ascochlorin, which is a publicly known fat-soluble antibiotic, and its homologues serve as a ligand of retinoid X receptor and react in vivo with the amino group of serum protein to form Schiff bases without showing any side effect of retinoid. Ascochlorin and its homologues are usable in treating and/or preventing a disease or condition which can be relieved by the retinoid X receptor ligand-dependent gene transcriptional regulation (for example, diseases caused by the expression of insulin resistance, hypertension, cerebrovascular diseases, rheumatoid arthritis, autoimmune disease, Ca metabolic disorder, complication of diabetes, arteriosclerosis, etc.). Moreover, they can inhibit denaturation and/or necrosis of pancreatic Langerhans islet &bgr;-cells and, therefore, are usable in making these cells to sustain the insulin productivity.Type: GrantFiled: June 14, 2001Date of Patent: August 12, 2003Assignee: Nuclear Receptor Research, Ltd.Inventors: Gakuzo Tamura, Kunio Ando, Junji Magae, Takafumi Uchida
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Patent number: 6541422Abstract: A method of selectively controlling undesirable vegetation in crops by using a postemergent application of an herbicidally effective amount of a metal chelate of a 2-(substituted benzoyl)-1,3-cyclohexanedione compound to the locus of such undesirable vegetation.Type: GrantFiled: May 28, 1999Date of Patent: April 1, 2003Assignee: Syngenta LimitedInventors: Herbert B. Scher, Jinling Chen
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Publication number: 20030060651Abstract: Benzoylcyclohexanedione derivatives of the formula (I) and their use as herbicides are described.Type: ApplicationFiled: April 4, 2002Publication date: March 27, 2003Inventors: Thomas Seitz, Andreas van Almsick, Lothar Willms, Thomas Auler, Herman Bieringer, Hubert Menne
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Patent number: 6515184Abstract: The present invention relates to novel bicyclic cyclopentane-1,3-dione derivatives of the formula (I) to a process for their preparation and to their use as pesticides and herbicides.Type: GrantFiled: April 6, 1998Date of Patent: February 4, 2003Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Michael Ruther, Alan Graff, Arno Widdig, Jacques Dumas, Christoph Erdelen, Peter Dahmen, Markus Dollinger, Ulrike Wachendorff-Neumann
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Patent number: 6492563Abstract: The present invention is a fragrance precursor of formula I: for a fragrant ketone of formula II: and a fragrant ester of formula III: wherein, R1 to R5 represent independently H, —NO2, linear or branched C1-C6-alkyl, C1-C6-alkenyl, C1-C6-alkinyl or C1-C4-alkoxy, R1 and R2,R2 and R3, R3 and R4, and R4 and R5 may form together one or two aliphatic or aromatic rings, R6 and R7 are independently H, linear or branched C1-C6-alkyl-, C1-C6-alkenyl, C1-C6-alkinyl, and R8 and R9 are the residues of an acid R8-COOH and an alcohol R9OH respectively forming the fragrant ester of formula III. A method for providing an odor by admixing with a product a fragrance precursor as detailed above.Type: GrantFiled: April 10, 2001Date of Patent: December 10, 2002Assignee: Givaudan SAInventors: Markus Gautschi, Caroline Plessis, Samuel Derrer
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Patent number: 6476266Abstract: Provided is a diamino compound suitable for obtaining a polyimide which can form a liquid crystal alignment film capable of providing a liquid crystal display element, an intermediate therefor and a production process for the same. The above production process is characterized by reacting a cyclohexylbenzene derivative represented by Formula (3): with an acid halide represented by Formula (4): by the Frieldel-Crafts reaction to produce a cyclohexylphenylcarbonyl compound, and reducing the above compound after nitrating, whereby a compound represented by Formula (1) is obtained: (wherein A1 represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms; A2 represents a single bond or an alkylene group having 1 to 5 carbon atoms, and one or optional methylene groups which are not adjacent in the group may be substituted with an oxygen atom; X is Br or Cl; m represents an integer of 0 to 3, and n represents an integer of 1 to 5).Type: GrantFiled: December 23, 1999Date of Patent: November 5, 2002Assignee: Chisso CorporationInventors: Takahiro Mori, Toshiya Sawai, Shizuo Murata, Masaaki Yazawa, Satoshi Tanioka, Kumiko Hara
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Patent number: 6468949Abstract: The present invention is directed to cyclopropyl-2,6,6-trimethylcyclohex-3-enyl ketone and is use in creating perfumes and scents in such items as perfumes, colognes, toilet water and personal care products.Type: GrantFiled: December 10, 2001Date of Patent: October 22, 2002Assignee: International Flavors & Fragrances Inc.Inventors: Richard M. Boden, William L. Schreiber
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Publication number: 20020094938Abstract: The present invention relates to photo-labile pro-fragrance conjugates comprising:Type: ApplicationFiled: November 2, 2001Publication date: July 18, 2002Applicant: The Procter & Gamble CompanyInventors: Robert Richard Dykstra, Gregory Scot Miracle, Lon Montgomery Gray
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Patent number: 6376429Abstract: Benzoylcyclohexanediones of the formula (I), process for their preparation and their use as herbicides and plant growth regulators are described. In this formula (I), R11, R2, R3, R4, R5, R6 and R7 are various radicals, L is an alkylene chain, and Y and Z are a monoatomic bridge element.Type: GrantFiled: October 7, 1999Date of Patent: April 23, 2002Assignee: Hoechst Schering AgrEvo GmbHInventors: Andreas Van Almsick, Lothar Willms, Thomas Auler, Hermann Bieringer, Christopher Rosinger
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Patent number: 6372693Abstract: The invention relates to 2-(3-alkenylbenzoyl)cyclohexane-1,3-diones of the formula I where the variables have the following meanings: R1, R2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, —OR6, —OCOR7, —OSO2R7, —SH, —S(O)nR8, —SO2OR6, —SO2NR6R9, —NR9SO2R7 or —NR9COR7; R3 is hydrogen, halogen, alkyl, haloalkyl, alkoxy, alkenyl, alkynyl; R4, R5 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, alkoxy, alkylthio, haloalkoxy, —COR10, —CO2R10, —COSR10, —CONR10R11, —C(R12)═NR13, —PO(OR10)(OR11); unsubstituted or substituted alkyl, heterocyclyl, heterocyclylalkyl, phenyl, phenylalkyl, hetaryl or hetarylalkyl; or R4 and R5 together form an alkanediyl chain which can be substituted and/or can be interrupted by a hetero atom; Q is an unsubstituted or substituted cyclohexane-1,3-dione ring whType: GrantFiled: November 2, 1999Date of Patent: April 16, 2002Assignee: BASF AktiengesellschaftInventors: Ernst Baumann, Wolfgang von Deyn, Stefan Engel, Regina Luise Hill, Uwe Kardorff, Guido Mayer, Martina Otten, Michael Rack, Joachim Rheinheimer, Matthias Witschel, Karl-Otto Westphalen, Ulf Misslitz, Helmut Walter
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Publication number: 20020028973Abstract: The invention deals with the derivate of benzelidine having basic formula as follows (I): 1Type: ApplicationFiled: December 21, 2000Publication date: March 7, 2002Applicant: The University of Gajah Mada, Faculty of Pharmacy.Inventors: M. S. Sardjiman, R. M. Samhoedi, H. Timmerman