Carbonyl Bonded Directly To Benzene Ring Patents (Class 568/331)
  • Patent number: 4412958
    Abstract: 5-Phenyl-2S-pentanol is synthesized stereospecifically from S ethyl lactate. The method provides easily purified 5-phenyl-2S-pentanol useful in the synthesis of central nervous system active (CNS) agents such as levonantradol.
    Type: Grant
    Filed: August 5, 1982
    Date of Patent: November 1, 1983
    Assignee: Pfizer Inc.
    Inventors: Berkeley W. Cue, Jr., Bernard S. Moore
  • Patent number: 4410732
    Abstract: Ketone derivatives represented by the general formula (I) ##STR1## where R is --CH.sub.2 R.sup.1 (where R.sup.1 is a hydrogen atom or an alkyl group), a halogen-substituted alkyl group, a cyano-substituted alkyl group, a cyclopropyl group, ##STR2## (where R.sup.2 is a hydrogen atom or an alkyl group and Y is a hydrogen atom or a halogen atom) or ##STR3## (where R.sup.3 is a hydrogen atom, an alkyl group, a phenyl group or a halogen-substituted phenyl group, and Z is a hydrogen atom or a halogen atom), and X is an oxygen atom or a sulfur atom.
    Type: Grant
    Filed: June 14, 1982
    Date of Patent: October 18, 1983
    Assignee: Nissan Chemical Industries Ltd.
    Inventors: Kiyomi Ozawa, Yasuyuki Nakajima, Makoto Tsugeno
  • Patent number: 4387089
    Abstract: The novel 4-(1,1-Dimethylethyl)-4'-methoxydibenzoylmethane is useful as a sunscreen agent. It exhibits outstanding UV-A absorbing qualities in that it brings about a considerable retardation in the ageing of the skin with excellent skin tolerance and stability (light, heat and moisture).4-(1,1-Dimethylethyl)-4'-methoxydibenzoylmethane furthermore improves the protective action of UV B-filters, i.e. of substances which absorb the erythema-producing UV B-radiation in the range of about 290 to 320 mm.
    Type: Grant
    Filed: May 18, 1981
    Date of Patent: June 7, 1983
    Assignee: Givaudan Corporation
    Inventor: Karl-Fred De Polo
  • Patent number: 4385185
    Abstract: Compounds of the general formula I: ##STR1## wherein R.sub.1 and R.sub.2 are equal or different alkyl-, alkoxyalkyl-, or aryl groups, or together form a ring; R.sub.3 is an allyl or benzyl radical; and R.sub.4 and R.sub.5 represent hydrogen, alkyl, alkoxyalkyl, alkenyl or further compounds of the formula II: ##STR2## wherein R.sub.1, R.sub.2, R.sub.4 and R.sub.5 have the meaning indicated above and R.sub.6 stands for hydrogen or methyl or to compounds which are modified by the addition of hydrogen to at least one olefinic or carbonylic double bond of compounds of the general formula I or II. The invention also relates to a process for preparing the new compounds. The compounds of the general formula II are obtained by thermal treatment of a selection of compounds of formula I, for which R.sub.3 stands for the allyl or methallyl radical. The compounds according to the invention are used as fragrant and flavoring substances.
    Type: Grant
    Filed: March 20, 1981
    Date of Patent: May 24, 1983
    Assignee: Consortium fur Elektrochemische Industrie GmbH
    Inventors: Helmut Gebauer, Walter Hafner
  • Patent number: 4358308
    Abstract: The 4-perfluoroacetyl-, 4-perfluoromethylthio-, 4-perfluoromethylsulfinyl-, and 4-perfluoromethylsulfonyl-4'-nitrodiphenyl ethers comprise a class of compounds that are highly effective herbicides.
    Type: Grant
    Filed: October 19, 1981
    Date of Patent: November 9, 1982
    Assignee: Rohm and Haas Company
    Inventor: Colin Swithenbank
  • Patent number: 4344954
    Abstract: This disclosure describes certain novel 2,3-disubstituted-2,3,5,6,7,8-hexahydro-thiazolo[3,2-][1,3]diazepin-3-ols which are useful as diuretic agents.
    Type: Grant
    Filed: July 9, 1980
    Date of Patent: August 17, 1982
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
  • Patent number: 4344789
    Abstract: Compounds, such as 5-(2-chloro-4-trifluoromethylphenoxy)-2-nitroacetophenone oxime-O-(acetic acid, methyl ester) and 5-(2-chloro-4-trifluoromethylphenoxy)-2-chloroacetophenone oxime-O-(acetic acid, methyl ester), are useful for postemergence and preemergence control of weeds, and are represented by Formula I of the application.
    Type: Grant
    Filed: April 15, 1980
    Date of Patent: August 17, 1982
    Assignee: PPG Industries, Inc.
    Inventor: Dennis K. Krass
  • Patent number: 4330552
    Abstract: Antiinflammatory 4,5-diaryl-2-arylthioimidazoles, such as 4,5-bis(4-methoxyphenyl)-2-(4-chlorophenylthio)-1H-imidazole useful for treatment of arthritis and related diseases.
    Type: Grant
    Filed: November 6, 1980
    Date of Patent: May 18, 1982
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Saul C. Cherkofsky
  • Patent number: 4308400
    Abstract: Aromatic-aliphatic ketones of the formulae I, II, III or IV ##STR1## wherein n is 1 or 2, Ar is an aryl radical, R.sup.1 and R.sup.2 are monvalent aliphatic, cycloaliphatic or araliphatic radicals, R.sup.3 is a direct bond or a divalent organic radical, X is a hydroxyl or amino group or the monovalent etherification or silylation products thereof, and X' is a divalent amino, ether or silyloxy group, Y is a direct bond or CH.sub.2 and Z is O, S, SO.sub.2, CH.sub.2 or C(CH.sub.3).sub.2, are suitable sensitizers for the photopolymerization of unsaturated compounds and for the photochemical crosslinking of polyolefins. Some of these compounds are novel and can be obtained by methods analogous to those for obtaining the known compounds of this type.
    Type: Grant
    Filed: December 28, 1979
    Date of Patent: December 29, 1981
    Assignee: Ciba-Geigy A.G.
    Inventors: Louis Felder, Rudolf Kirchmayr, Rinaldo Husler
  • Patent number: 4301166
    Abstract: The invention relates to hydroxyethyl-azole compounds and methods for their preparation. Also included in the invention are compositions containing said hydroxyethyl-azole compounds and methods for the use of said compounds and compositions as antimycotic agents.
    Type: Grant
    Filed: November 9, 1979
    Date of Patent: November 17, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erik Regel, Karl H. Buchel, Ingo Haller, Manfred Plempel
  • Patent number: 4297515
    Abstract: Diketones of the formula ##STR1## wherein R.sub.1 is alkyl, perfluoroalkyl or alkoxy, each of 1-18 carbon atoms; R.sub.2 is alkyl or perfluoroalkyl, each of 1-12 carbon atoms; and X is 1,4-trans-cyclohexylene, 1,4-phenylene or 4,4'-cyclohexylphenyl are liquid crystalline compounds.
    Type: Grant
    Filed: May 9, 1980
    Date of Patent: October 27, 1981
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Rudolf Eidenschink, Ludwig Pohl
  • Patent number: 4287213
    Abstract: Compounds having the formula ##STR1## wherein one of X or Y is chloro and the other is trifluoromethyl or wherein X is hydrogen and Y is chloro and methods of preparing said compounds.The compounds can be prepared by the reaction of the corresponding 1-acetyl substrate with chlorine or sulfuryl chloride and are useful as mite ovacides.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: September 1, 1981
    Assignee: Chevron Research Company
    Inventor: John W. Kobzina
  • Patent number: 4284639
    Abstract: 1-Phenoxy-2-(2,4-dichlorophenyl)-1-(1,2,4-triazol-1-yl)-ethan-2-ones and -ols of the formula ##STR1## in which A is --C(O)-- or --CH(OH)--,X each independently is halogen, alkyl or optionally substituted phenyl, andn is 0, 1, 2 or 3,or a salt thereof, which possess fungicidal and antimicrobial properties rendering them useful in agriculture and pharmacy.
    Type: Grant
    Filed: February 28, 1980
    Date of Patent: August 18, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Wilhelm Brandes, Paul-Ernst Frohberger, Manfred Plempel
  • Patent number: 4275071
    Abstract: Imidazole derivatives of the formula I and pharmaceutically acceptable acid addition salts thereof are provided: ##STR1## In the formula, R.sub.4 1- or 2-naphthyl, optionally substituted with Cl, Br, or I; 1,2,3,4-tetrahydro-6-naphthyl; 3-duryl, optionally 6-substituted by Cl, Br, I, NO.sub.2, CH.sub.3 or benzyl; mesityl, phenyl 2-, 3- or 4-substituted by OH, NH.sub.2, NO.sub.2, CH.sub.3 CONH, phenyl, phenoxy, cyclohexyl, phenylthio, benzylthio, C.sub.1 -C.sub.6 alkyl or C.sub.1 C.sub.6 alkylthio; 4-bibenzylyl; 3,4-dihydroxyphenyl,n=0, 1 or 2 and(a) R=H, alkyl having 1 to 6 carbon atoms or phenyl R.sub.1 =H, alkyl having 1 to 6 carbon atoms or phenyl one of R.sub.2 and R.sub.3 =H the other of R.sub.2 and R.sub.3 =H, OH, benzoyloxy, C.sub.2 -C.sub.7 alkanoyloxy, N-(C.sub.1 -C.sub.6 alkyl)-carbamoyloxy, N,N-[di-(C.sub.1 C.sub.6)alkyl]-carbamoyloxy, but if R.sub.2 =R.sub.3 =H then R=R.sub.1 =H, or(b) R=H, C.sub.1 -C.sub.6 alkyl, phenyl R.sub.1 =H, C.sub.1 -C.sub.6 alkyl, phenyl R.sub.2 +R.sub.
    Type: Grant
    Filed: July 10, 1979
    Date of Patent: June 23, 1981
    Assignee: Recordati S.A.
    Inventors: Dante Nardi, Alberto Tajano, Maria J. Magistretti
  • Patent number: 4271319
    Abstract: The present invention relates to a novel organic compound, phenyl beta-chloro-alpha-hydroxy-beta-(3-trifluoromethylphenyl)ethyl ketone. This compound may be produced by:(a) condensing 3-trifluoromethylbenzaldehyde with acetophenone under basic conditions to form a substituted chalcone,(b) epoxidation of the substituted chalcone to produce the corresponding epoxide, and(c) converting the epoxide to a chlorohydrin, phenyl beta-chloro-alpha-hydroxy-beta-(3-trifluoromethylphenyl)ethyl ketone.
    Type: Grant
    Filed: May 14, 1979
    Date of Patent: June 2, 1981
    Assignee: Hooker Chemicals & Plastics Corp.
    Inventors: David Y. Tang, Arthur M. Foster
  • Patent number: 4261928
    Abstract: 4-(Aryloxyalkyl)pyrazoles of the formula ##STR1## useful as antiviral agents, are prepared by reacting the corresponding diketones of the formula Ar--O--Alk--CH(COR')COR" with hydrazine or a substituted hydrazine H.sub.2 NNHR.
    Type: Grant
    Filed: October 24, 1979
    Date of Patent: April 14, 1981
    Assignee: Sterling Drug Inc.
    Inventors: Guy D. Diana, Philip M. Carabateas
  • Patent number: 4258213
    Abstract: Compounds wherein 2-nitrobenzofuran is substituted by one or two phenyl groups and certain other substituents which are active as antimicrobial agents, processes for their use and intermediates therefor.
    Type: Grant
    Filed: January 21, 1980
    Date of Patent: March 24, 1981
    Assignee: Riker Laboratories, Inc.
    Inventors: Walton J. Hammar, Mark A. Rustad
  • Patent number: 4231965
    Abstract: 2-Nitrobenzofurans in which the furan ring is either fused to or substituted by a fused bicyclic system, which are active as antimicrobial agents, processes for their use and intermediates therefor are described.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: November 4, 1980
    Assignee: Riker Laboratories, Inc.
    Inventors: Robert A. Scherrer, Richard M. Stern
  • Patent number: 4225619
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is perfluoroalkyl of 1 to 8 carbon atoms or 2,2,3,3-tetrafluoro-cyclobutyl,R.sub.2 and R.sub.4, which may be identical to or different from each other, are each hydrogen, alkyl of 1 to 10 carbon atoms, aliphatic acyl of 2 to 18 carbon atoms, benzoyl, salicyloyl or phenylacetyl, andR.sub.3 and R.sub.5, which may be identical to or different from each other, are each alkyl of 3 to 18 carbon atoms, halogen, nitro, p-toluenesulfonyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclododecyl, methylcyclohexyl, dimethylcyclohexyl, benzyl, methylthio or ##STR2## where R.sub.1, R.sub.2 and R.sub.4 have the meanings previously defined,Q is --CH.sub.2 -- or --S--, andG is R.sub.5, as above defined, orQ is R.sub.3, as above defined, andG is --CH.sub.2 -- or --S--,R.sub.3 may, in addition, also be hydroxyl, methoxy, methyl or cyano, andR.sub.5 may also be methyl, orone of substituents R.sub.3 and R.sub.
    Type: Grant
    Filed: March 19, 1979
    Date of Patent: September 30, 1980
    Assignee: Boehringer Ingelheim GmBH
    Inventors: Rolf Brickl, Hans Eberhardt, Karl-Richard Appel, Uwe Lechner, Walter Merk
  • Patent number: 4225730
    Abstract: 5-(2,4-difluorophenyl)salicylic acid, an anti-inflammatory, anti-pyretic, analgesic agent is prepared by: (1) diazotizing 2,4-difluoroaniline in the presence of benzene to yield 2,4-difluorobiphenyl; (2) Friedel-Crafts acylation to produce 2',4'-difluoro-4-alkanoylbiphenyl; (3) oxidation of the alkanoyl group to produce 2',4'-difluoro-4-alkanoyloxybiphenyl; (4) hydrolysis of the alkanoyl group to produce 4-(2,4-difluorophenyl)phenol; and (5) Kolbe-Schmitt carboxylation to produce the final product.
    Type: Grant
    Filed: May 11, 1978
    Date of Patent: September 30, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Howard Jones, Robert W. Houser
  • Patent number: 4222888
    Abstract: Novel mesomorphic substances, constituting, in certain temperature ranges, nematic or smectic liquid crystals which are compounds of the formula: ##STR1## wherein R.sub.1 is an alkoxy group containing 1 to 10 atoms of carbon;R.sub.2 is an alkyl group containing 1 to 10 atoms of carbon;X is Br or CN.
    Type: Grant
    Filed: May 3, 1979
    Date of Patent: September 16, 1980
    Assignee: Thomson-CSF
    Inventors: Jean-Claude Dubois, Tinh H. Nguyen, Annie Zann
  • Patent number: 4212762
    Abstract: Novel mesomorphic substances, constituting, in certain temperature ranges, nematic or smectic liquid crystals which are compounds of the formula: ##STR1## wherein R.sub.1 is an alkyl or alkoxy group containing 1 to 10 atoms of carbon;R.sub.2 is Br, CN or an alkyl (or an alkoxy) group containing 1 to 10 atoms of carbon.
    Type: Grant
    Filed: November 21, 1978
    Date of Patent: July 15, 1980
    Assignee: Thomson-CSF
    Inventors: Jean-Claude Dubois, Huu Tinh Nguyen, Annie Zann
  • Patent number: 4206230
    Abstract: There are provided insecticidal ketones having the general structure ##STR1## insecticidal compositions containing the ketones and a carrier, and the method of controlling insects with the ketones.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: June 3, 1980
    Assignee: Mobil Oil Corporation
    Inventor: Jill H. Paul
  • Patent number: 4202960
    Abstract: Thermostable, infusible and insoluble polymer obtained by thermosetting aromatic oligomers of low molecular weight in the presence of an acid catalyst, said aromatic oligomers having an average molecular weight up to about 5000, a softening temperature from 80.degree. to 400.degree. C. and being obtained by separation from the reaction mixture produced by reacting meta-terphenyl with acetyl chloride and aluminum chloride.
    Type: Grant
    Filed: September 16, 1977
    Date of Patent: May 13, 1980
    Assignee: Institut Francais du Petrole
    Inventors: Guy Rabilloud, Bernard Masson, Pierre Giuliani, Bernard Sillion