Oxy Containing Patents (Class 568/336)
  • Patent number: 8952192
    Abstract: Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: February 10, 2015
    Assignee: University of Maryland, College Park
    Inventors: Herman O. Sintim, William E. Bentley, Varnika Roy, Jacqueline Smith, Reza Ghodssi, Mariana Tsacoumis Meyer
  • Publication number: 20140275400
    Abstract: The present invention provides methylene beta-diketone monomers, methods for producing the same, and compositions and products formed therefrom. In the method for producing the methylene beta-diketones of the invention, a beta-diketone is reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to further processing, which may be vaporization by contact with an energy transfer means in order to isolate the beta-diketone monomer. The present invention further compositions and products formed from methylene beta-diketone monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).
    Type: Application
    Filed: October 18, 2012
    Publication date: September 18, 2014
    Inventors: Yangbin Chen, Adam G. Malofsky, Jeffrey M. Sullivan, Stanley C. Wojciak, Tanmoy Dey, Bernard M. Malofsky
  • Publication number: 20140221632
    Abstract: The present invention disclosed a preparation method of parylene AF4, which provides a reactant and a reducing agent with the use of catalyst or exposure to UV light with photo-initiator, to shorten the reaction time as a result of minimized the byproduct(s) formation, and obtain high purity (>99.0%) of parylene AF4 product under high concentrated reaction mixture.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Inventors: Chun-Hsu LIN, Chian-Yi SUN, Yung-Yu YIN, Chun-Shih LI, Yo-Chun CHOU
  • Publication number: 20140011986
    Abstract: The present invention disclosed a preparation method of parylene AF4, which provides a reactant and a reducing agent with the use of catalyst or exposure to UV light with photo-initiator, to shorten the reaction time as a result of minimized the byproduct(s) formation, and obtain high purity (>99.0%) of parylene AF4 product under high concentrated reaction mixture.
    Type: Application
    Filed: September 21, 2012
    Publication date: January 9, 2014
    Inventors: Chun-Hsu LIN, Chien-Yi SUN, Yung-Yu YIN, Chun-Shih LI, Yo-Chun CHOU
  • Patent number: 8603947
    Abstract: A description is given of (4-haloalkyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, Y, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: December 10, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Hartmut Ahrens, Dieter Feucht, Elmar Gatzweiler, Isolde Haeuser-Hahn, Christopher Hugh Rosinger
  • Publication number: 20130109759
    Abstract: A formulation comprising an ophthalmically effective amount of one or more quinones of Formula I. Use of a formulation comprising one or more quinones of Formula I for the prevention, reduction, amelioration or treatment of ophthalmic disorders that are associated with a neurodegenerative or trauma disorder is also discussed. A method of treating or controlling the ocular symptoms associated with neurodegenerative diseases or trauma with a formulation comprising one or more quinones of Formula I is also discussed. A method of treating or controlling the ocular symptoms associated with mitochondrial myopathies with a formulation comprising one or more quinones of Formula I is also discussed.
    Type: Application
    Filed: April 26, 2011
    Publication date: May 2, 2013
    Inventor: Guy M. Miller
  • Publication number: 20120294900
    Abstract: Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.
    Type: Application
    Filed: March 26, 2012
    Publication date: November 22, 2012
    Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Herman Sintim, William E. Bentley, Varnika Roy, Jacqueline Smith
  • Publication number: 20120101296
    Abstract: The present invention relates to a method for preparing a tricyclic derivative, and more particulary, to a method for preparing a tricyclic derivative inetermediate with high yield and purity, the method including: introducing a hydroxy group by esterifying and substituting 2-fluoroisophthalic acid compound; introducing a piperidyl group; introducing a hydroxy group through reduction reaction; and then hydrolyzing the resultant compound, and to a method for preparing the tricyclic derivative using said intermediate. According to the method of the present invention, it is possible to provide a tricyclic derivative and an intermediate thereof with high productivity and economic feasibility as well as high purity and yield, by purifying a compound using re-crystallization unlike typical methods of using column chromatography.
    Type: Application
    Filed: June 29, 2010
    Publication date: April 26, 2012
    Applicant: JE IL PHARMACEUTICAL CO., LTD.
    Inventors: Myung-Hwa Kim, In-Hae Ye, Jong-Hee Choi
  • Patent number: 8058309
    Abstract: The present invention provides new tyrphostin derivatives acting as substrate competitive protein tyrosine kinase (PTK) inhibitors and receptor tyrosine kinase (RTK) inhibitors, methods of their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for preventions and treatments of PTK and RTK related disorders such as metabolic, fibrotic, and cell proliferative disorders, in particular psoriasis and cancer.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: November 15, 2011
    Assignee: Novotyr Therapeutics Ltd.
    Inventors: Hadas Reuveni, Alexander Levitzki, Lilach Steiner, Revital Sasson, Iris Ben-David, Avi Weissberg
  • Patent number: 8058210
    Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: November 15, 2011
    Assignee: Bayer Cropscience AG
    Inventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretschneider, Christoph Erdelen, Wolfram Andersch, Mark-Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
  • Publication number: 20110237685
    Abstract: Photolabile fragrance storage substances capable of photo-induced release of odorant aldehydes and odorant ketones are described in addition to a process for long-lasting fragrancing of surfaces and a process for producing said fragrance storage substances.
    Type: Application
    Filed: June 9, 2011
    Publication date: September 29, 2011
    Applicant: Henkel AG & Co. KGaA
    Inventors: Ursula Huchel, Christian Kropf, Axel Griesbeck, Olga Hinze, Uta Sundermeier
  • Publication number: 20110082312
    Abstract: The present invention relates to a process for the preparation of compounds containing CF3O groups using compounds containing at least one group Y, in which Y=—Hal, —OSO2(CF2)zF, —OSO2CzH2z+1 (z=1-10), —OSO2F, —OSO2Cl, —OC(O)CF3— or —OSO2Ar, to a process for the preparation of compounds containing CF3O groups using KOCF3 and/or RbOCF3, and to novel compounds containing CF3O groups, and to the use thereof.
    Type: Application
    Filed: May 4, 2009
    Publication date: April 7, 2011
    Applicant: MERCK PATENT GESELLSCHAFT MIT DESCHRANKTER HAFTUNG
    Inventors: Nikolai (Mykola) Ignatyev, Wolfgang Hierse, Martin Seidel, Andreas Bathe, Jens Schroeter, Karsten Koppe, Thorsten Meier, Peter Barthen, Walter Frank
  • Publication number: 20110046219
    Abstract: Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 2-(3-hydroxy-3-methyl-butyl)-6-(het)aryl-p-quinone or as 2-(3-hydroxy-3-methylbutyl)-3-(het)aryl-p-quinone derivatives. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
    Type: Application
    Filed: January 6, 2009
    Publication date: February 24, 2011
    Inventors: Andrew W. HIinman, Kieron E. Wesson
  • Patent number: 7868054
    Abstract: The present invention concerns photopolymerisable systems comprising reactive oligomers and/or monomers having ethylenically unsaturated groups and at least one phenylglyoxalic ester that, by photochemical decomposition, generates fragments having low migratability and low odor.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: January 11, 2011
    Assignee: Lamberti SpA
    Inventors: Stefano Romagnano, Gabriele Norcini, Marco Visconti, Giuseppe Libassi
  • Patent number: 7723397
    Abstract: The invention relates to novel photoinitiators of formula (I) wherein A is —O—, —CH2?, CH(CH3)— or —C(CH3)2?, and R is methyl or trimethylsilyl, and R may in addition be hydrogen when A is simultaneously the group —C(CH3)2?. The invention relates also to compositions comprising (A) at least one ethylenically unsaturated compound, (B) a photoinitiator of formula (I), (C) optionally further binders or additives, (D) optionally further photoinitiators or co-initiators. Compositions comprising (A) an ethylenically unsaturated compound that contains at least one aminoacrylate, (B) a photoinitiator of formula (II) or (III), (C) optionally further binders or additives, (D) optionally further photoinitiators or co-initiators.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: May 25, 2010
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Rinaldo Hüsler, André Fuchs
  • Patent number: 7649019
    Abstract: The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: January 19, 2010
    Assignee: Biovail Laboratories International S.R.L.
    Inventors: Werner Oberegger, Fang Zhou, Paul Maes, Graham Jackson, Mohammad Ashty Saleh
  • Patent number: 7598289
    Abstract: The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formulae and pharmaceutically acceptable salts, amides, esters, and ethers thereof, wherein: Ar1, Ralk, —ORO, and -Q are as defined herein: The present invention also pertains to pharmaceutical compositions comprising such compounds. The compounds inhibit osteoclast survival, formation, and/or activity, and inhibit conditions mediated by osteoclasts and/or characterised by bone resorption, and are useful in the treatment of bone disorders such as osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, aseptic loosening of prosthetic implants, and the like; and/or in the treatment of conditions associated with inflammation or activation of the immune system.
    Type: Grant
    Filed: August 19, 2008
    Date of Patent: October 6, 2009
    Assignee: The University Court of the University of Aberdeen
    Inventors: Stuart H. Ralston, Iain R. Greig, Aymen I. I. Mohamed, Robert J. Van 'T Hof
  • Patent number: 7586008
    Abstract: The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: September 8, 2009
    Assignee: Abraxis Bioscience, Inc.
    Inventors: Chunlin Tao, Cheng Zhi Yu, Neil P. Desai, Vuong Trieu
  • Patent number: 7572935
    Abstract: The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: August 11, 2009
    Assignee: Biovail Laboratories International S.R.L.
    Inventors: Werner Oberegger, Paul Maes, Stefano Turchetta, Pietro Massardo, Mohammad Ashty Saleh
  • Patent number: 7538252
    Abstract: The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.
    Type: Grant
    Filed: September 5, 2007
    Date of Patent: May 26, 2009
    Assignee: BiPar Sciences, Inc.
    Inventors: Valeria Ossovskaya, John Burnier, Barry Sherman, Max Totrov
  • Patent number: 7462650
    Abstract: The Invention relates to novel ketones of formulae (I) and (II) wherein R1, R2, R3 and R4 are, for example, C1-C8alkyl, R5 is, for example, hydrogen, A is CI, Br, -0-R7, —NR8R9 or —S—R16, A? is —O—, —NH— or —NR8—, X and Y are each independently of the other —O—R10 or —N(R11)(R12), n is an integer from 1 to 10, R6 is, for example, an n-valent radical of linear or branched C2-C20alkyl the carbon chain of which may be interrupted by cyclohexanediyl, phenylene, —CH(OH)—, —C(C2H5)(CH2—CH2—OH)—, —C(CH3)(CH2—CH2—OH)—, —C(CH2—CH2—OH)2—, —N(CH3)—, —N(C2H5)—, —N(CH2—CH2—OH)—, —CO—O—, —O—CO—, —P(CH2—CH2—OH)—, —P(O)(CH2—CH2—OH)—, -0-P(O—CH2—CH2—OH)—O—, -0-P(O)(0-CH2—CH2—OH)—O—, —O-cyclohexanediyl-C(CH3)2-Cyclohexanediyl-O—, —O-phenylene-C(CH3)2-phenylene-O—, —O-phenylene-CH2-phenylene-O—, —Si(CH3)2—, -0-Si(CH3)2—O—, —O—Si(CH3)(0-CH3)—O—, —Si(CH3)(R17)—O—Si(CH3)(R18)—, 5-(2-hydroxyethyl)-[1,3,5]triazinane-2,4,6-trione-1,3-diyl and/or by from one to nine oxygen atoms.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: December 9, 2008
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Reinhard H. Sommerlade, Rinaldo Hüsler, Stephan Ilg, André Fuchs, Souâd Boulmaâz, Jean-Luc Birbaum
  • Patent number: 7154007
    Abstract: This invention provides: a compound represented by formula (I): R—Y—(—X-Phe-COCH2COCnF2n+1)m ??(I) wherein R denotes hydrogen, alkyl, phenyl, or a group capable of binding to a protein, peptide, amino acid, nucleic acid, or nucleotide; Y denotes CH2, a carbocyclic ring, or a heterocyclic ring; X denotes O, S, NH, CH2, OCH2, CONH, or NHCO; Phe denotes phenylene; n is an integer between 1 and 5; and m is 1, 2, or 3. This inventions also provides a luminous complex of such compound and a rare earth ion, a labeling reagent comprising such compound or luminous complex, and a process for labeling a protein, peptide, amino acid, nucleic acid, or nucleotide using such labeling reagent.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: December 26, 2006
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Michihiro Saito, Ernoe Pretsch
  • Patent number: 7084183
    Abstract: The invention relates to ?-hydroxy ketones of formula I or IIa; or mixtures of compounds of formula I and II; or mixtures of compounds of formulae Ia and IIa
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: August 1, 2006
    Assignee: Ciba Specialty Chemcials Corp.
    Inventors: André Fuchs, Rinaldo Hüsler, Christian Schregenberger, Martin Kunz
  • Patent number: 7074966
    Abstract: This application relates to a new process for the production of R-phenylacetylcarbinol by an enzymatic process in a liquid two-phase system.
    Type: Grant
    Filed: September 1, 2002
    Date of Patent: July 11, 2006
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernhard Hauer, Michael Breuer, Peter Rogers, Vanessa Sandford, Bettina Rosche
  • Patent number: 7012160
    Abstract: The present invention provides a new fluorine-containing acetophenone derivative useful as a photo initiator, and a surface layer material containing the fluorine-containing acetophenone derivative. The present invention provides inexpensively an article with a hard coat excellent in anti-staining property, lubricity, scratch resistance and abrasion resistance, and provides a method for forming the hard coat. A fluorine-containing acetophenone derivative represented by the following general formula (I): wherein R1, R2 and R3 each independently represent an organic group other than aryl group, a hydrogen atom, a halogen atom or a hydroxyl group, provided that the following case does not take place: all of R1, R2 and R3 are simultaneously hydrogen atoms; and any two of R1, R2 and R3 may be linked to each other to form a ring, and R4 represents a fluorine-containing organic group.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: March 14, 2006
    Assignee: TDK Corporation
    Inventors: Naoki Hayashida, Kazushi Tanaka
  • Patent number: 6949680
    Abstract: A compound of formula wherein Y represents a pyridyl group, or a phenyl group of formula wherein R3 represents a hydrogen atom, a CF3 group or an alkoxy group, R4 represents a hydrogen atom, an alkyl group, or a CF3 group, R5 represents a hydrogen atom, an alkyl group, a CF3 group or an alkoxy group, and R1 and R2 are the substituents of a terminal alkene of formula wherein R1 represents an alkyl or alkylene group, a mono- or poly-cycloalkyl group, or a phenyl group that optionally includes one or several hetero-atoms of oxygen, nitrogen, phosphorous or sulfur; R2 represents a hydrogen atom, an alkyl or alkylene group, a mono- or poly-cycloalkyl group, or a phenyl group that optionally includes one or several hetero-atoms of oxygen, nitrogen, phosphorous and sulfur.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: September 27, 2005
    Assignee: Firmenich SA
    Inventor: Andreas Herrmann
  • Patent number: 6930207
    Abstract: Novel and known trifluoroacetyl-substituted phenyl, phenol and benzoyl compounds for the treatment and/or inhibition of obesity and of concomitant and/or secondary diseases involved therewith, in particular metabolic syndrome and cardiovascular diseases. Novel trifluoroacetyl-substituted phenyl, phenol and benzoyl compounds, pharmaceutical preparations containing them and processes for the preparation of these compounds. Also compounds acting as inhibitors of lipase, in particular pancreatic lipase.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: August 16, 2005
    Assignee: Solvay Pharmaceutical GmbH
    Inventors: Jochen Antel, Harald Waldeck, Andreas Potthoff, Sabine Irmer, Peter-Colin Gregory
  • Patent number: 6730814
    Abstract: This invention relates to a process for the preparation of acylated aromatic ethers, in particular the acylation of anisole (methoxybenzene) and veratrole (1,2-dimethoxybenzene) for the preparation of corresponding acylated aromatic ether, namely, p-methoxyacetophenone and 3,4-dimethoxyacetophenone respectively, using clay based heterogeneous catalysts, and their lanthanide exchanged forms at moderate temperature and pressure with high selectivity.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: May 4, 2004
    Assignee: Council of Scientific and Industrial Research
    Inventors: Rakesh Vir Jasra, Muthusamy Sengodagounder, Yogiraj Mansukhlal Badheka
  • Publication number: 20030191242
    Abstract: The invention relates to metathesis polymers wherein an aromatic group that has UV-light absorbing properties is attached with a bridge group to the polymer. Also disclosed is a polymerisable composition comprising a catalytically effective amount of a penta- or hexavalent ruthenium or osmium carbene catalyst, the process for preparing the metathesis polymer by applying the reaction conditions of Ring Opening Metathesis Polymerisation (=ROMP) to the polymerisable composition; and various technical applications of the metathesis polymers.
    Type: Application
    Filed: November 29, 2002
    Publication date: October 9, 2003
    Inventors: Alessandro Zedda, Dario Lazzari, Massimiliano Sala, Michela Bonora, Manuele Vitali, Paul Adriaan Van Der Schaaf
  • Patent number: 6589921
    Abstract: Compounds of the formula: in which the dotted lines indicate the position of single or double bonds, R1 represents a radical belonging to a fragrant alcohol of the formula R1OH, X represents a nucleophilic group selected from the group consisting of —OH, ═O, —NH2 or —NHR3, R3 representing a C1 to C6 straight-chain or branched hydrocarbon radical, saturated or unsaturated, or an aliphatic or aromatic ring having 5 or 6 carbon atoms, m and n define whole numbers within the range 0 to 2 such that the sum m+n is equal to 1 or 2, p defines a whole number with a value of 0 or 1, each of the symbols R2, R4, R5, R6, R7, taken independently, represents a hydrogen atom, a C1 to C4 straight-chain or branched hydrocarbon radical, saturated or unsaturated optionally substituted, and, taken two by two, they can form aromatic or aliphatic monocyclic, bicyclic or tricyclic substances with the carbon atoms to which they are bound.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: July 8, 2003
    Assignee: Firmenich SA
    Inventors: Andreas Herrmann, Jean-Yves Billard De Saint-Laumer, Otto Gräther
  • Patent number: 6455578
    Abstract: The present invention is directed to aromatic derivatives of formula (I), wherein: R1 is (a), wherein R3 and R4 are selected from between H and OH, provided that R3 and R4 are not simultaneously H, and R2 is H; or R1 and R2 taken together, are (b), wherein R5 is selected from between CH3 and (CH2)5OH, to the iron complexes thereof, and to their use for the preparation of pharmaceutical compositions for the normalization of iron level.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: September 24, 2002
    Assignee: Laboratoire Medidom S.A.
    Inventor: Guido Di Napoli
  • Patent number: 6441244
    Abstract: The invention relates to new compounds of the formula (I) in which R is phenyl, C1-4alkyl-, C1-4alkoxy- or halogen-substituted phenyl, naphthyl or an aromatic ring containing heteroatoms; X is O or S; R1 and R2 are each a methyl radical or R1 and R2 together are a C4-8alkylene radical; Y is hydroxyl, C1-12alkoxy, C1-4alkylamino, di-C1-4alkylamino or a piperidine or morpholine ring that is attached by its nitrogen atom; to a process for preparing them and to their use as photoinitiators and/or photosensitizers.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: August 27, 2002
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Lajos Avar, René Bär, Victor Sanahuja
  • Publication number: 20020077508
    Abstract: The present invention is a fragrance precursor of formula I: 1
    Type: Application
    Filed: April 10, 2001
    Publication date: June 20, 2002
    Inventors: Markus Gautschi, Caroline Plessis, Samuel Derrer
  • Patent number: 6388123
    Abstract: The present invention relates to novel compounds of the formula (I) in which Het represents one of the groups  in which A, B, D, G, V, W, X, Y and Z are as defined in the description, processes and intermediates for their preparation, and to their use as pesticides and herbicides.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: May 14, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Volker Lieb, Hermann Hagemann, Arno Widdig, Michael Ruther, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Alan Graff, Udo Schneider
  • Patent number: 6380436
    Abstract: A new process is described for the preparation of (alkoxyalkyl)(4-trifluoromethylphenyl)methanones. The process comprises reacting a 4-trifluoromethylbenzonitrile with an alkoxyalkyl Grignard in the presence of a suitable polar aprotic solvent. The compound (4-methoxybutyl)(4-trifluoromethylphenyl)methanone is useful as an intermediate in the preparation of the antidepressant drug fluvoxamine.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: April 30, 2002
    Assignee: Sun Pharmaceutical Industries Ltd.
    Inventors: Rajamannar Thennati, Keshav Deo, Ajay Sohanlal Midha, Tilak Chandra, Vijay Muljihhai Patel
  • Patent number: 6284915
    Abstract: A process for preparing 2-amino malonic acid derivatives of formula (1): wherein A is linear or branched chain alkylene having from 1 to 10 carbon atoms, R1 is linear or branched chain alkyl having from 2 to 20 carbon atoms, R2 and R3 are the same or different, and are lower alkyl or aralkyl, and R4 is a protecting group, which process comprises the steps of reducing a compound of formula (6): wherein A is linear or branched chain alkylene having from 1 to 10 carbon atoms, R1 is linear or branched chain alkyl having from 2 to 20 carbon atoms, R2 and R3 are the same or different, and are lower alkyl or aralkyl, and R4 is a protecting group.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: September 4, 2001
    Assignees: Taito Co., LTD, Welfide Corporation
    Inventors: Susumu Hirase, Shigeo Sasaki, Masahiko Yoneta, Ryoji Hirose, Tetsuro Fujita
  • Publication number: 20010008945
    Abstract: A process for preparing 2-amino malonic acid derivatives of formula (1): 1
    Type: Application
    Filed: March 3, 1999
    Publication date: July 19, 2001
    Inventors: SUSUMU HIRASE, SHIGEO SASAKI, MASAHIKO YONETA, RYOJI HIROSE, TETSURO FUJITA
  • Patent number: 6225500
    Abstract: This invention discloses an improved method for the [2+2+2] cyclotrimerization reaction in aqueous solutions using a water soluble transition metal catalyst.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: May 1, 2001
    Assignee: Invenux, Inc.
    Inventors: Bruce Eaton, Matthew S. Sigman
  • Patent number: 6008268
    Abstract: A method of generating reactive species which includes exposing a photoreactor composition to radiation, in which the photoreactor composition comprises a wavelength-specific sensitizer associated with one or more reactive species-generating photoinitiators. Also described are methods of polymerizing unsaturated monomers and curing an unsaturated oligomer/monomer mixture.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: December 28, 1999
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Ronald Sinclair Nohr, John Gavin MacDonald
  • Patent number: 5942290
    Abstract: Molecular complex compounds comprising a mono-, bis- or trisacylphosphine oxide compound with an .alpha.-hydroxy ketone compound are suitable as photoinitiators for the photopolymerization of free-radically polymerizable compounds.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: August 24, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: David George Leppard, Thomas Lloyd James, Nils Hock, Manfred Kohler, Ronald Salathe
  • Patent number: 5866723
    Abstract: The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of aryl-haloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: February 2, 1999
    Assignee: Monsanto Company
    Inventors: Bruce C. Hamper, Kindrick L. Leschinsky
  • Patent number: 5739175
    Abstract: A method of generating reactive species which includes exposing a photoreactor composition to radiation, in which the photoreactor composition comprises a wavelength-specific sensitizer associated with a reactive species-generating photoinitiator. Also described are methods of polymerizing unsaturated monomers and curing an unsaturated oligomer/monomer mixture.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 14, 1998
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Ronald Sinclair Nohr, John Gavin MacDonald
  • Patent number: 5684206
    Abstract: Novel .beta.-aminovinyl ketones of the general formula ##STR1## wherein R.sup.1 is, in particular, an alkenyl, alkynyl, cycloalkyl or cycloalkenyl group; R.sup.2 is, in particular, an electron-attracting substituent such as nitro, acyl, ester, alkylthio, carbamoyl, thiocarbamoyl or haloalkyl; R.sup.3 is, in particular, an alkyl or alkoxy group or a halogen atom; n is 1 or 2 and m is 0, 1, 2 or 3. A method for preparing such compounds by carrying out a condensation reaction between ketone R.sup.1 --CO--CH.sub.3 and, in particular, benzonitrile substituted by (R.sup.2).sub.n and optionally (R.sup.3).sub.m, in the presence of a strong base, as well as a process employing said .beta.-aminovinyl ketones of general formula (VI) for preparing the corresponding .beta.-diketones, are also disclosed.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: November 4, 1997
    Assignee: Rhone-Poulenc Argochimie
    Inventors: Michel Casado, Pierre Le Roy, Virginie Pevere
  • Patent number: 5650533
    Abstract: The invention relates to 4-substituted isoxazole derivatives of formula I: ##STR1## wherein R, R.sup.1, R.sup.2, Q and n have the meaning defined in the description which possess valuable herbicidal properties.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 22, 1997
    Assignee: Rhone-Poulenc Agriculture Ltd.
    Inventors: David Alan Roberts, Susan Mary Cramp, Derek Ian Wallis, Jean-Paul Bulot
  • Patent number: 5516931
    Abstract: A release tag reagent suitable for use in the chemical analysis of a substance to be detected comprises signal, release, and reactivity groups. A class of release tag compounds that are cleaved to release as signal groups very stable electrophoric ketones which are sufficiently volatile for determination in the gas phase of an analytical reaction mixture is disclosed.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: May 14, 1996
    Assignee: Northeastern University
    Inventors: Roger W. Giese, Samy Abdel-Baky, Linxiao Xu
  • Patent number: 5510539
    Abstract: Liquid highly active photoinitiators are obtained by dissolving a solid photoinitiator of the titanocene type in liquid photoinitiators of the acetal or ketal type. The liquid mixtures have a long dark storage stability.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: April 23, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Godwin Berner, Franciszek Sitek, Rinaldo Husler
  • Patent number: 5506348
    Abstract: The invention relates to a composition comprising(a) at least one ammonium salt of an inorganic or organic acid,(b) a compound of formula I ##STR1## wherein R is an aliphatic hydrocarbon radical of 1 to 12 carbon atoms or an aliphatic hydrocarbon radical of 2 to 12 carbon atoms which is interrupted by --O-- atoms, and n is an integer from 1 to 5, and(c) at least one high molecular weight compound selected from the group consisting of the polynucleotides, oligosaccharides, proteins and macrocyclic metal complexes, and to the use thereof for the matrix-assisted laser desorption mass spectroscopy of oligonucleotide sequences.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: April 9, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Uwe Pieles
  • Patent number: 5475145
    Abstract: The present invention is directed to compositions containing novel beta-diketones of formula (I) and formula (II),R.sub.1 COCH.sub.2 COR.sub.2 (I)R.sub.2 COCH.sub.2 COR.sub.2 (II)which may be used to stabilize various polymers, such as polyvinyl chlorides (PVCs). The present invention is also directed to a method for preparing .beta.-diketones by a Claisen condensation reaction, which is represented as follows:R.sub.4 COCHR.sub.5 H+R.sub.6 C(O)OR.sub.7 +RO.sup.- .fwdarw.[R.sub.4 COCR.sub.5 COR.sub.6 ]--+R.sub.7 OH+ROH.
    Type: Grant
    Filed: November 5, 1993
    Date of Patent: December 12, 1995
    Assignee: Rhone-Poulenc
    Inventors: Serge Chassaing, Michel Gay, Gilles Mur
  • Patent number: 5466873
    Abstract: Arylketoamines are prepared by reacting arylisonitrosoalkanones with hydrogen in the presence of a transition metal catalyst and a liquid carboxylic acid at a temperature of less than about 600.degree. C.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: November 14, 1995
    Assignee: Hoechst Celanese Corporation
    Inventors: Ahmed M. Tafesh, George Kvakovszky, Charlet R. Lindley
  • Patent number: 5466721
    Abstract: Provided are compounds having the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are independently selected from the group consisting of a hydrogen atom, an aliphatic group, a hetero-aliphatic group, an aromatic group, and a heterocyclic group, provided that R.sup.1 and R.sup.2 may together form a divalent radical selected from the group consisting of an aliphatic radical and hetero-aliphatic group;each R.sup.3 is independently selected from the group consisting of an aliphatic group, a hetero-aliphatic group, an aromatic group, and a heterocyclic group;R.sup.4 is selected from the group consisting of an aliphatic group, a hetero-aliphatic group, an aromatic group, and a heterocyclic group; andn is an integer from 0 to 5.Also provided are polymerizable compositions containing such compounds and a method of coating a substrate which uses such polymerizable compositions.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: November 14, 1995
    Assignee: Henkel Corporation
    Inventor: Paul E. Share