Benzene Ring Containing Patents (Class 568/425)
  • Patent number: 9988592
    Abstract: An aryl-substituted alkanal compound having a molecular weight of less than 300 g/mol and which bears a substituent on the aryl ring ortho to a substituent bearing the aldehyde functionality. Said compounds are useful as perfume ingredients in personal care and household care products.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: June 5, 2018
    Assignee: Givaudan, S.A.
    Inventors: Andreas Goeke, Philip Kraft, Heike Laue, Yue Zou, Francis Voirol
  • Patent number: 9708570
    Abstract: meta-Substituted 3-phenylpropanal derivatives useful in providing watery-marine, floral-aldehydic notes.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: July 18, 2017
    Assignee: Givaudan, S.A.
    Inventors: Andreas Goeke, Philip Kraft, Yue Zou
  • Patent number: 9656938
    Abstract: An aryl-substituted alkanal compound having a molecular weight of less than 300 g/mol and which bears a substituent on the aryl ring ortho to a substituent bearing the aldehyde functionality. Said compounds are useful as perfume ingredients in personal care and household care products.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: May 23, 2017
    Assignee: Givaudan S.A.
    Inventors: Andreas Goeke, Philip Kraft, Heike Laue, Yue Zou, Francis Voirol
  • Patent number: 9296675
    Abstract: Provided are a compound of formula (1), having a cyclopropane ring, which can impart a floral or citrus-like aroma and a flavor composition containing at least one compound of formula (1): wherein, R1, R2, R3 and R5 independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, wherein at least two groups among R1, R2, R3 and R5 independently represent an alkyl group; R4 represents a group selected from a formyl group, a hydroxymethyl group, a 1-hydroxy-1-ethyl group, a 1-hydroxy-1-propyl group, a 1-hydroxy-1-butyl group and a 2-hydroxy-1-propyl group; m represents 0 to 2; n represents 0 or 1; and a wavy line stands for a cis-configuration, a trans-configuration or a mixture of a cis-configuration and a trans-configuration with respect to position-2 on a cyclopropane ring.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: March 29, 2016
    Assignee: TAKASAGO INTERNATIONAL CORPORATION
    Inventor: Kenichi Yamamoto
  • Patent number: 9101783
    Abstract: The invention relates to a malodor counteractancy or counteracting (MOC) method that resorts to the use of specific malodor counteracting (MOC) mixtures of MOC ingredients. More particularly, the invention relates to new MOC compositions capable of neutralizing or masking in an efficient manner sweat malodor and which can be used in perfumes, deodorants, antiperspirants and other body care products.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: August 11, 2015
    Assignee: Firmenich SA
    Inventors: Myriam Troccaz, Sabine Beccucci, Monica Bandera, Manuel Bourgaux, Catherine Selig, Magali Lateulere, Anthony Clark
  • Patent number: 9029592
    Abstract: The present invention relates to a process of making a compound of formula (I): Wherein, R1, R2, R4 and X are as defined herein.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: May 12, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Keith R. Fandrick, Joe Ju Gao, Jason Alan Mulder, Nitinchandra D. Patel, Xingzhong Zeng
  • Publication number: 20150111991
    Abstract: There are provided a novel aromatic aldehyde compound capable of providing an epoxy resin coating film and an epoxy resin cured material satisfying all of the excellent surface property (smoothness, gloss), drying property, water resistance, transparency and adhesion, and an epoxy resin curing agent and an epoxy resin composition containing the aromatic aldehyde compound. The aromatic aldehyde has a branched alkyl group having 10 to 14 carbon atoms.
    Type: Application
    Filed: May 17, 2013
    Publication date: April 23, 2015
    Applicant: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Mitsuharu Kitamura, Yutaka Matsuura, Hisayuki Kuwahara, Tomotaka Wada, Yuiga Asai
  • Patent number: 8962862
    Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 24, 2015
    Assignee: Cambrex Karlskoga AB
    Inventors: Lars Eklund, Lars Hansson, Tommy Lundholm, Pär Holmberg, Margus Eek
  • Publication number: 20150018577
    Abstract: This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 15, 2015
    Inventors: Fabrice Gallou, Joerg Matthias Sedelmeier, Caspar Vogel
  • Publication number: 20140314699
    Abstract: The present invention concerns a compound of formula wherein R represents a hydrogen atom or a C1-2 alkyl or alkoxyl group; each R1, R2 or R3 represents a hydrogen atom or a methyl or ethyl group; and X represents a CHO, COOR4 or CN group, R4 being a methyl or ethyl group; and at least one of said R, R1 or R2 represents a group containing at least one carbon atom; and it use as perfuming ingredient, for instance to impart odor notes of the floral and/or anis type.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 23, 2014
    Applicant: FIRMENICH SA
    Inventor: Robert MORETTI
  • Publication number: 20140271537
    Abstract: The present invention generally relates to deuterium-enriched aldehydes, compositions comprising deuterium-enriched aldehydes, and methods for slowing the rate of aldehyde autoxidation. In one aspect, the present invention provides a composition comprising a compound of structure 1: wherein: there are at least 6×1018 molecules of the aldehyde and Rx is hydrogen, wherein the deuterium isotope in Rx is in an amount greater than 0.10 percent of the hydrogen atoms present in Rx.
    Type: Application
    Filed: March 15, 2014
    Publication date: September 18, 2014
    Inventor: Anthony W. Czarnik
  • Patent number: 8815792
    Abstract: The present invention concerns a compound of formula wherein R represents a hydrogen atom or a C1-2 alkyl or alkoxyl group; each R1, R2 or R3 represents a hydrogen atom or a methyl or ethyl group; and X represents a CHO, COOR4 or CN group, R4 being a methyl or ethyl group; and at least one of said R, R1 or R2 represents a group containing at least one carbon atom; and it use as perfuming ingredient, for instance to impart odor notes of the floral and/or anis type.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: August 26, 2014
    Assignee: Firmenich SA
    Inventor: Robert Moretti
  • Patent number: 8779003
    Abstract: Disclosed herein is a method for prolonging analgesic effect of a membrane permeable local anesthetic in a subject in need thereof. The method uses cinnamaldehyde as an adjuvant which, when administered prior to or simultaneously with the administration of a local anesthetic, prolongs the analgesic effect of the local anesthetic. Also disclosed herein is a method for providing analgesic effect in a subject in need thereof. The method uses cinnamaldehyde as an analgesic compound which, when administered alone to the subject in an analgesically effective amount, provides the analgesic effect.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: July 15, 2014
    Assignee: Mackay Memorial Hospital
    Inventor: Yu-Chun Hung
  • Publication number: 20140187789
    Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.
    Type: Application
    Filed: July 20, 2012
    Publication date: July 3, 2014
    Applicant: CAMBREX KARLSKOGA AB
    Inventors: Lars Eklund, Lars Hansson, Tommy Lundholm, Pär Holmberg, Margus Eek
  • Publication number: 20140142343
    Abstract: A compound having the structure wherein R is hydrogen or methyl, having a strong odour and for use as a perfumery ingredient.
    Type: Application
    Filed: December 2, 2013
    Publication date: May 22, 2014
    Applicant: Givaudan Nederland Services B.V.
    Inventor: Anne Dominique Fortineau
  • Patent number: 8686193
    Abstract: The invention relates to a process for the preparation of m-substituted phenylalkanols of the formula (I) in which R1 is C1-C5-alkyl and R2, R3, R4 and R5, independently of one another, are hydrogen or methyl, wherein a p-substituted phenylalkanol of the formula (II) in which R1, R2, R3, R4 and R5 having the meanings given under formula (I), is isomerized in the presence of a Friedel-Crafts catalyst to give an m-substituted phenylalkanol of the formula (I). From the m-substituted phenylalkanols of the formula (I) it is possible to form, by oxidation or dehydrogenation, as products of value, the corresponding aldehydes, which are known as fragrances and aroma chemicals.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: April 1, 2014
    Assignee: BASF SE
    Inventors: Andreas Lanver, Klaus Ebel, Karl Beck, Ralf Pelzer, Jörg Botzem, Ulrich Griesbach
  • Patent number: 8557262
    Abstract: The present invention provides divinyl ether derivatives capable of releasing in a controlled manner at least one active aldehyde and/or ketone into the surrounding environment. The invention relates to the use of these divinyl ether derivatives as perfuming or flavoring ingredients, as well as to the perfuming compositions and consumer articles containing them.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: October 15, 2013
    Assignee: Firmenich SA
    Inventors: Gary Bernard Womack, Robert Langley Fuller, Glenn Paul Johannes Verhovnik, Nathalie Pinel, Magali Lateulere, Marie Buy
  • Publication number: 20130225815
    Abstract: A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1.
    Type: Application
    Filed: February 19, 2013
    Publication date: August 29, 2013
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: John F. Hartwig, Hiroyuki Morimoto, Patrick Fier
  • Publication number: 20130216492
    Abstract: Provided are a method for searching for a malodor inhibitor by using the response of an olfactory receptor as an indicator; a method for inhibiting malodor based on the antagonism of olfactory receptors; and a malodor inhibitor. Disclosed are a method for searching for a malodor inhibitor, the method including: adding a test substance and a malodor-causing substance to any one olfactory receptor selected from the group consisting of OR51E1, OR2W1, OR10A6, OR51I2, and OR51L1, measuring the response of the olfactory receptor to the malodor-causing substance, identifying the test substance that suppresses the response of the olfactory receptor on the basis of the measured response, and selecting the identified test substance as a malodor inhibitor; an antagonist to any one olfactory receptor selected from the group consisting of OR51E1, OR2W1, OR10A6, OR51I2, and OR51L1; a method for inhibiting malodor using the antagonist.
    Type: Application
    Filed: September 1, 2011
    Publication date: August 22, 2013
    Applicant: KAO CORPORATION
    Inventors: Aya Kato, Naoko Saito, Etsuji Wakisaka
  • Publication number: 20130211130
    Abstract: The present invention relates to a process of making a compound of formula (I): Wherein, R1, R2, R4 and X are as defined herein.
    Type: Application
    Filed: February 7, 2013
    Publication date: August 15, 2013
    Applicant: Boehringer Ingelheim International Gmbh
    Inventors: Keith R. FANDRICK, Joe Ju GAO, Jason Alan MULDER, Nitinchandra D. PATEL, Xingzhong ZENG
  • Publication number: 20130122599
    Abstract: A mass spectrometry electron transfer dissociation reagent comprising an unsaturated compound having a Frank Condon factor between 0.1 and 1.0 and an electron affinity having a positive value between 0.1 to 150 kJ/mol.
    Type: Application
    Filed: January 31, 2011
    Publication date: May 16, 2013
    Applicant: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Iain Campuzano, Darryl W. Brousmiche, Craig Dorschel, Jonathan Paul Williams, Steven Derek Pringle, Keith Richardson
  • Publication number: 20120316341
    Abstract: Methods for fluorinating organic compounds are described herein.
    Type: Application
    Filed: April 11, 2012
    Publication date: December 13, 2012
    Inventors: Tobias Ritter, Pingping Tang
  • Publication number: 20120251449
    Abstract: The present invention claims fluoro- & iodo-containing aldehydes as ALDH substrates for use as diagnostic imaging agents or as therapeutic agents. The aldehydes are both directly and indirectly attached to an aromatic or a straight chain ring. ALDH activity was monitored either by the formation of acid-product or consumption of aldehyde substrates.
    Type: Application
    Filed: December 22, 2010
    Publication date: October 4, 2012
    Inventors: Vijaya Raj Kuniyil Kulangara, Alan Cuthbertson, Peter Iveson, Chitralekha Rangaswamy, Veena Rao, Rajiv Bhalla
  • Patent number: 8258349
    Abstract: A benzaldehyde acetal compound of formula (3): (wherein Q represents a hydrogen atom or a halogen atom, Ar represents a phenyl group optionally substituted with at least one selected from the group consisting of alkyl groups having 1 to 4 carbon atoms and halogen atoms, and R represents an alkyl group having 1 to 4 carbon atoms).
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: September 4, 2012
    Assignee: Suitomo Chemical Company, Limited
    Inventor: Koichi Nakazawa
  • Publication number: 20120209031
    Abstract: The invention relates to a process for the preparation of m-substituted phenylalkanols of the formula (I) in which R1 is C1-C5-alkyl and R2, R3, R4 and R5, independently of one another, are hydrogen or methyl, wherein a p-substituted phenylalkanol of the formula (II) in which R1, R2, R3, R4 and R5 having the meanings given under formula (I), is isomerized in the presence of a Friedel-Crafts catalyst to give an m-substituted phenylalkanol of the formula (I). From the m-substituted phenylalkanols of the formula (I) it is possible to form, by oxidation or dehydrogenation, as products of value, the corresponding aldehydes, which are known as fragrances and aroma chemicals.
    Type: Application
    Filed: October 19, 2010
    Publication date: August 16, 2012
    Applicant: BASF SE
    Inventors: Andreas Lanver, Klaus Ebel, Karl Beck, Ralf Pelzer, Jörg Botzem, Ulrich Griesbach
  • Patent number: 8216974
    Abstract: There is provided a fluorine-containing organosulfur compound having an excellent controlling effect on arthropod pests represented by the formula (I): wherein G represents an oxygen atom or a sulfur atom; R2 represents a C1-C4 chain hydrocarbon group which is optionally substituted with a halogen atom, etc.; R3 and R4 independently represent a C1-C4 chain hydrocarbon group or a hydrogen atom; R5 represents a C1-C5 haloalkyl group containing at least one fluorine atom, or a fluorine atom; R6 represents a halogen atom, a cyano group, a nitro group or a -(G1)q-R8 group; R7 represents an amino group etc.; R8 represents a C1-C4 chain hydrocarbon group which is optionally substituted with a halogen atom; m represents an integer of 0 to 5; n represents an integer of 0 to 2; p represents 0 or 1; q represents 0 or 1; and G1 represents an oxygen atom etc.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: July 10, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Koji Kumamoto, Hiroyuki Miyazaki
  • Publication number: 20120164576
    Abstract: A cyclic compound represented by formula (1): wherein L, R1, R?, and m are as defined in the specification. The cyclic compound of formula (1) is highly soluble to a safety solvent, highly sensitive, and capable of forming resist patterns with good profile. Therefore, the cyclic compound is useful as a component of a radiation-sensitive composition.
    Type: Application
    Filed: August 30, 2010
    Publication date: June 28, 2012
    Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventors: Hiromi Hayashi, Masatoshi Echigo, Dai Oguro
  • Publication number: 20120164355
    Abstract: A liquid crystal compound of Formula (1) is provided. In Formula (1), R is hydrogen, linear or branching C1-15 alkyl, linear or branching C1-15 alkyl (wherein any one of —CH2— is replaced by —O—, —S—, —CO—, —CO—O—, or —O—CO—), linear or branching C2-15 alkenyl, or linear or branching C2-15 alkenyl (wherein any one of —CH2— is replaced by —O—, —S—, —CO—, —CO—O—, or —O—CO—), A and B are, independently, cyclohexane, cyclohexane (wherein any one of —CH2— is replaced by —O— or —NH—), benzene, or benzene (wherein any one of —CH2? is replaced by —N?), X is a single bond, —CO—O—, —O—CO—, —CH2O—, —OCH2—, —CH2CH2—, —C?C—, —C?C—, —CF2O—, or —OCF2—, Q is oxygen or CH2, Y is CF3, CF2H, or CFH2, L1, L2, and L3 are, independently, hydrogen or fluorine, and m is 0, 1, or 2.
    Type: Application
    Filed: June 10, 2011
    Publication date: June 28, 2012
    Inventors: Pei-Chen Huang, Kuo-Chang Wang, Kuo-Liang Yeh, An-Cheng Chen, Kung-Lung Cheng, Shyue-Ming Jang
  • Publication number: 20120148690
    Abstract: A novel skin barrier function recovery acceleration method and accelerator are provided. The present invention provides a skin barrier function recovery accelerator that comprises a TRPA1 agonist capable of activating TRPA1 in epidermal cells.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 14, 2012
    Inventors: Mitsuhiro Denda, Moe Tsutsumi, Sumiko Denda
  • Patent number: 8197722
    Abstract: Compositions capable of simultaneous two-photon absorption and higher order absorptivities are provided. Compounds having a donor-pi-donor or acceptor-pi-acceptor structure are of particular interest, where the donor is an electron donating group, acceptor is an electron accepting group, and pi is a pi bridge linking the donor and/or acceptor groups. The pi bridge may additionally be substituted with electron donating or withdrawing groups to alter the absorptive wavelength of the structure. Also disclosed are methods of generating an excited state of such compounds through optical stimulation with light using simultaneous absorption of photons of energies individually insufficient to achieve an excited state of the compound, but capable of doing so upon simultaneous absorption of two or more such photons. Applications employing such methods are also provided, including controlled polymerization achieved through focusing of the light source(s) used.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: June 12, 2012
    Assignee: The California Institute of Technology
    Inventors: Seth Marder, Joseph Perry
  • Patent number: 8168784
    Abstract: Processes to make compounds, including N-acylsulfonamide apoptosis promoters are disclosed.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: May 1, 2012
    Assignee: Abbott Laboratories
    Inventors: Thaddeus Stephan Franczyk, II, David R. Hill, Anthony Ralph Haight, Maureen Ann McLaughlin, Shashank Shekhar, Su Yu, Jianzhang Mei, Lei Wang
  • Patent number: 8119566
    Abstract: The present invention relates to novel 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I) in which A, D, G, W, X, Y and Z are as defined above, to a plurality of processes for the preparation and to their use as pesticides and/or herbicides and/or microbicides. Moreover, the invention relates to selective herbicidal compositions comprising both the 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I) and a crop plant compatibility-improving compound.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: February 21, 2012
    Assignee: Bayer CropScience AG
    Inventors: Reiner Fischer, Thomas Bretschneider, Ernst Rudolf F. Gesing, Dieter Feucht, Karl-Heinz Kuck, Peter Lösel, Olga Malsam, Christian Arnold, Thomas Auler, Martin Jeffrey Hills, Heinz Kehne
  • Publication number: 20110286922
    Abstract: The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of tumours and treatment of cancer.
    Type: Application
    Filed: October 20, 2009
    Publication date: November 24, 2011
    Inventors: Alan Cuthbertson, Peter Brian Iveson, Rajiv Bhalla, Vijaya Raj Kuniyil Kulangara
  • Publication number: 20110281949
    Abstract: Use of alkyl phenol and monocyclic monoterpene-derived compounds in the treatment of neuronal damage and in inhibiting activity of TRPC and non-thermo-TRPM channels, and use of bicyclic monoterpene-derived compounds in activating TRPC and non-thermo-TRPM channels.
    Type: Application
    Filed: February 3, 2011
    Publication date: November 17, 2011
    Inventors: Baruch Minke, Moshe Parnas
  • Publication number: 20110263696
    Abstract: Compositions comprising proanthocyanidin compositions (e.g. those extracted from cinnamomum species) that are observed to bind tau and inhibit its aggregation as well as methods for making and using such compositions are disclosed. In certain embodiments of the invention, the proanthocyanidins can be used as a probe to identify and/or characterize tau isoforms in a variety of contexts. In other embodiments of the invention, these compositions are used in methods designed to treat neurological disorders associated with tau aggregation (e.g. Alzheimer's disease).
    Type: Application
    Filed: March 31, 2008
    Publication date: October 27, 2011
    Inventors: Donald J. Graves, John Lew
  • Publication number: 20110229426
    Abstract: The present invention concerns the use as perfuming ingredient, for instance to impart odor notes of the floral and/or green type, of a compound of formula 5 wherein R is an ortho, meta or para substituent of the phenyl, and represents a hydrogen atom or a C 1-2 alkyl or alkoxyl group; R 1 represents a hydrogen atom or a methyl or ethyl group; 10 R 2 represents a hydrogen atom or a C 1-3 alkyl group; and X represents a CHO, COOR 3, CH(OR 4) 2 or CN group, R 3 being a methyl or ethyl group, and R 4, taken seperately, being a methyl or ethyl group, or said R 4, taken together, a C 2-5 alkanediyl group; and at least one of said R, R 1 or R 2 represents a group containing at least one carbon atom.
    Type: Application
    Filed: November 3, 2009
    Publication date: September 22, 2011
    Inventor: Robert Moretti
  • Patent number: 7968727
    Abstract: 4-bromomethyl-2?-formylbiphenyl and 4-bromomethyl-2?-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2?-cyanobiphenyl or 4?-bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: June 28, 2011
    Assignee: Lek Pharmaceuticals, D.D.
    Inventors: Anton Copar, Ljubomir Antoncic, Matej Antoncic
  • Publication number: 20110061563
    Abstract: An ecologically compatible anti-microbial-adhesion agent is described, which is particularly suitable for use in anti-fouling paints, preferably for boats, characterized in that it comprises a compound selected from eugenol, vanillin, benzaldehyde substituted with one or two substituents selected from the groups —OH (hydroxy) and —OCH3 (methoxy), or any combination thereof. An anti-fouling paint is also described, particularly for boats, comprising the anti-microbial-adhesion agent mentioned above and other components selected from conventional biocides, solvents, resins, pigments, charges and fillings, and combinations thereof.
    Type: Application
    Filed: May 12, 2009
    Publication date: March 17, 2011
    Inventors: Cecilia Calisti, Giulio Zanaroli, Fabio Fava, Alessandra Bontempi Di Roccaspada, Maurizio Ruzzi
  • Patent number: 7897819
    Abstract: This invention provides a method for producing an optically active aziridine compound or amine compound, which uses as a catalyst a Ru(salen)(CO) complex represented by the following formula (I) or its enantiomer having a high stability, in a high turnover number (TON) and a high enantioselectivity. In the formula (I), Ar is represented by the following formula (VI) or (VII), wherein in the formula (VI), Xs are independently a halogen or a halogenated alkyl group and R1 and R2s are independently hydrogen or an alkyl group or a trialkylsilyl group having a carbon number of 1-4, and in the formula (VII), R3 is a bulky group.
    Type: Grant
    Filed: January 5, 2010
    Date of Patent: March 1, 2011
    Assignee: Japan Science and Technology Agency
    Inventors: Tsutomu Katsuki, Kazufumi Omura, Tatsuya Uchida, Ryo Irie
  • Patent number: 7858381
    Abstract: Improved process for preparing high-purity, halogen-free o-phthalaldehyde, in which a) tetrahalo-o-xylene is hydrolyzed at a temperature of 155-160° C. and a pressure of from 2 to 5 bar, where appropriate in the presence of a phase-transfer catalyst, to o-phthalaldehyde, which b) is converted in an acidic alcoholic solution at a temperature of from 0 to the reflux temperature into the corresponding dialkoxyphthalane and, subsequently, c) an acetal cleavage is effected by acid hydrolysis at a pH >1.5 to pH 7, resulting in high-purity, halogen-free o-phthalaldehyde.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: December 28, 2010
    Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KG
    Inventors: Karlheinz Giselbrecht, Klaus Reiter, Rudolf Hermanseder
  • Publication number: 20100256421
    Abstract: A product of p-tert-butylphenyl propionaldehyde and m-tert-butylphenyl propionaldehyde, wherein m-tert-butylphenyl propionaldehyde is in an amount from 6% to 60% of the combination of p-tert-butylphenyl propionaldehyde and m-tert-butylphenyl propionaldehyde. Also a method including; adding dropwise an aldehyde solution to a basic solution; and, collecting a fraction of p-tert-butyl cinnamic aldehyde m-tert-butyl cinnamic aldehyde therefrom; and, adding a transition metal catalyst to a solution of the p-tert-butyl cinnamic aldehyde in ethanol, and, collecting therefrom by distillation a product of p-tert-butylphenyl propionaldehyde and the meta isomer m-tert-butylphenyl propionaldehyde; wherein the product comprises m-tert-butylphenyl propionaldehyde in an amount from 6% to 60% of the combination of p-tert-butylphenyl propionaldehyde and m-tert-butylphenyl propionaldehyde.
    Type: Application
    Filed: March 23, 2010
    Publication date: October 7, 2010
    Applicant: O'LAUGHLIN INDUSTRIES, CO. LTD.
    Inventors: Zhiguo Gao, Jun Li, Xin Qi
  • Publication number: 20100247475
    Abstract: Provided are a novel ?-glucuronidase inhibitor including a compound selected from a macrocyclic ketone, a ketone, a macrocyclic lactone, a macrocyclic oxalactone, an ester, an aldehyde, an alcohol, and a terpene of specific kinds, and an environmental hygiene product and a sanitary product each containing the ?-glucuronidase inhibitor. Also provided are a composition for suppressing the generation of urine odor and a method of suppressing the generation of urine odor each using a ?-glucuronidase inhibitor.
    Type: Application
    Filed: September 19, 2008
    Publication date: September 30, 2010
    Applicant: KAO CORPORATION
    Inventors: Ichiro Mori, Shunichi Akiba
  • Publication number: 20100234456
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
    Type: Application
    Filed: May 25, 2010
    Publication date: September 16, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
  • Patent number: 7777081
    Abstract: A process for effectively producing a 4-(4-alkylcyclohexyl)benzaldehyde, 4-(cyclohexyl)benzaldehyde, a 4-(trans-4-alkylcyclohexyl)benzaldehyde and a (trans-4-alkylcyclohexyl)benzene useful for electronic material applications such as liquid crystals and for pharmaceutical and agrochemical applications, etc., are disclosed. The present invention provides (1) a process for producing a 4-(4-alkylcyclohexyl)benzaldehyde or 4-(cyclohexyl)benzaldehyde by formylating a (4-alkylcyclohexyl)benzene or cyclohexylbenzene with carbon monoxide, (2) a process for producing a 4-(trans-4-alkylcyclohexyl)benzaldehyde by formylating a (4-alkylcyclohexyl)benzene having a cis/trans molar ratio of 0.3 or less with carbon monoxide, and (3) a process for producing a (trans-4-alkylcyclohexyl)benzene by isomerizing a mixture of the cis and trans isomers of a (4-alkylcyclohexyl)benzene, all of the processes being performed in the presence of HF and BF3.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: August 17, 2010
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Mitsuharu Kitamura, Junya Nishiuchi, Norio Fushimi
  • Publication number: 20100204084
    Abstract: The present invention relates to a process for the production of formyl cyclohexene derivatives which are suitable as odorants as such or as intermediates for the preparation of further odorants.
    Type: Application
    Filed: August 8, 2008
    Publication date: August 12, 2010
    Applicant: Givaudan SA
    Inventors: Andreas Goeke, Yue Zou
  • Patent number: 7740812
    Abstract: The present invention relates to a method and an apparatus for continuously separating aromatic dialdehyde from a reaction mixture obtained by gas-phase oxidation of dimethylbenzene. The method for continuously separating aromatic dialdehyde includes the steps of congealing aromatic dialdehyde by cooling the gas-phase reaction mixture including the aromatic dialdehyde, which is obtained by gas-phase oxidation of dimethylbenzene, to 5-70° C. and separating the congealed aromatic dialdehyde from the remaining reaction mixture. Using the method and apparatus in accordance with the present invention, aromatic dialdehyde can be effectively and selectively separated from a reaction mixture obtained by gas-phase oxidation of dimethylbenzene in high yield.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: June 22, 2010
    Assignee: LG Chem, Ltd.
    Inventors: Jong-Hyun Chae, Won-Ho Lee, Dong-Il Lee, Hyun-Kyung Yoon
  • Publication number: 20100152083
    Abstract: The present application relates to perfume raw materials, perfume systems and consumer products comprising such perfume raw materials and/or such perfume systems, as well as processes for making and using such, perfume systems and consumer products. The perfume compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: December 16, 2008
    Publication date: June 17, 2010
    Inventors: Jose Maria Velazquez, Rafael Trujillo Rosaldo, Philip John Porter, Zerlina Guzdar Dubois, Yoshimi Sunohara, Javier Medina, Michael Green, Hugo Robert Germain Denutte, Jonathan Richard Clare, Stacy Renee Hertenstein
  • Patent number: 7732643
    Abstract: The present invention relates to a transition metal complex represented by the formula (I): wherein M represents a Group 4 transition metal; —Y— represents (a): —C(R1)(R20)-A-, (b): —C(R1)(R20)-A1(R30)—, (c): —C(R1)=A1-, or (d): —C(R1)=A1-A2-R30; A represents a Group 16 element and A1 and A2 each represents a Group 15 element; R1 to R9, R20, and R30 are the same or different and each represents an optionally substituted hydrocarbon group, etc.; and X1 and X2 are the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C1-10 alkyl group, etc., and an intermediate product thereof, and a catalyst for olefin polymerization which comprises said transition metal complex as a component.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: June 8, 2010
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hidenori Hanaoka, Eiji Yoshikawa, Yuka Imamoto
  • Publication number: 20100113807
    Abstract: A solid phase reaction system for oxidation of an organic compound, having high industrial value in which an organic solvent exerting a reverse influence on earth environments is not necessary, reuse of a catalyst is possible, and high yield can be attained, comprising a mixture of a powdery dispersion medium and a powder of a solid catalyst for the above-described oxidation reaction, and the above-described organic compound and aqueous hydrogen peroxide, wherein the above-described organic compound, the above-described solid catalyst and the above-described aqueous hydrogen peroxide are dispersed in the above-described mixture so that they get into contact mutually.
    Type: Application
    Filed: January 30, 2008
    Publication date: May 6, 2010
    Applicant: OSAKA UNIVERSITY
    Inventors: Jyunko Ichihara, Syunrou Yamaguchi
  • Publication number: 20100113835
    Abstract: This invention provides a method for producing an optically active aziridine compound or amine compound, which uses as a catalyst a Ru(salen)(CO) complex represented by the following formula (I) or its enantiomer having a high stability, in a high turnover number (TON) and a high enantioselectivity. In the formula (I), Ar is represented by the following formula (VI) or (VII), wherein in the formula (VI), Xs are independently a halogen or a halogenated alkyl group and R1 and R2s are independently hydrogen or an alkyl group or a trialkylsilyl group having a carbon number of 1-4, and in the formula (VII), R3 is a bulky group.
    Type: Application
    Filed: January 5, 2010
    Publication date: May 6, 2010
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Tsutomu Katsuki, Kazufumi Omura, Tatsuya Uchida, Ryo Irie