Oxygen Containing Patents (Class 568/62)
  • Patent number: 10544094
    Abstract: A process includes reacting, in a reactor having a fixed bed containing a solid catalyst which contains a heterogeneous ion exchange resin, hydrogen sulfide and ethylene oxide in the presence of the solid catalyst to yield a reaction product which contains beta-mercaptoethanol. A reactor system includes the reactor, an ethylene oxide stream, a hydrogen sulfide stream, a fixed bed containing the solid catalyst placed in the reactor, and an effluent stream containing the reaction product. During steady state operation of the reactor in the process and the reactor system, the hydrogen sulfide and the ethylene oxide are present in a mole ratio in a range of about 9:1 to about 20:1.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: January 28, 2020
    Assignee: Chevron Philips Chemical Company, LP
    Inventors: Daniel M. Hasenberg, Alex Pauwels
  • Patent number: 9193679
    Abstract: The invention related to a process for the preparation of a bismercaptodiether by reacting a polysulfide with a monothiol in the presence of a base and to a process for the depolymerization of a polysulfide by reacting said polysulfide with a monothiol in the presence of a base. These processes enable the preparation of bismercaptodiethers without inorganic salt formation.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: November 24, 2015
    Assignee: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
    Inventors: Rudolf Anthonius Maria Venderbosch, Hendrika Petronella Maria Verlaan-Hooft, Auke Gerardus Talma, Olaf Klobes, Ralf Tatas, Hendrik Jan Vos
  • Patent number: 9006492
    Abstract: The invention related to a process for the preparation of a bismercaptodiether by reacting a polysulfide with a monothiol in the presence of a base and to a process for the depolymerization of a polysulfide by reacting said polysulfide with a monothiol in the presence of a base. These processes enable the preparation of bismercaptodiethers without inorganic salt formation.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: April 14, 2015
    Assignee: Akzo Nobel Chemicals International B.V.
    Inventors: Rudolf Anthonius Maria Venderbosch, Hendrika Petronella Maria Verlaan-Hooft, Auke Gerardus Talma, Olaf Klobes, Ralf Tatas, Hendrik Jan Vos
  • Patent number: 8957253
    Abstract: A hexafluorodimethylcarbinol terminated compound, method of making it, and a composition of matter are disclosed. The compound may have the formula (CF3)2C(OH)-L-M-R. The substructure L may be selected from an optionally substituted propenylene group (—CH2CH?CH—) and trimethylene group (—CH2CH2CH2—). The substructure M may be selected from a substituted or unsubstituted methylene chain, a substituted or unsubstituted oxyalkylene chain, and a silicon-containing chain or combination thereof. In one embodiment, M may be selected from —(CH2)n—, —(OCH2CH2)m—, and —(Si(CH3)2O)p—Si(CH3)2— (CH2)q—, wherein n is at least 1, e.g., n is up to 10, m can be at least 1, e.g., m is up to 10, p can be 0 and in one embodiment is from 1 to 10, and wherein q can be 1 and in one embodiment is from 1 to 12. The substructure R represents one of a halogen, —SH, —SZ, —S—S-M-L-C(CF3)2(OH), wherein Z represents a thiol protecting group.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 17, 2015
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventor: Arthur W. Snow
  • Publication number: 20140330043
    Abstract: A hexafluorodimethylcarbinol terminated compound, method of making it, and a composition of matter are disclosed. The compound may have the formula (CF3)2C(OH)-L-M-R. The substructure L may be selected from an optionally substituted propenylene group (—CH2CH?CH—) and trimethylene group (—CH2CH2CH2—). The substructure M may be selected from a substituted or unsubstituted methylene chain, a substituted or unsubstituted oxyalkylene chain, and a silicon-containing chain or combination thereof. In one embodiment, M may be selected from —(CH2)n—, —(OCH2CH2)m—, and —(Si(CH3)2O)p—Si(CH3)2— (CH2)q—, wherein n is at least 1, e.g., n is up to 10, m can be at least 1, e.g., m is up to 10, p can be 0 and in one embodiment is from 1 to 10, and wherein q can be 1 and in one embodiment is from 1 to 12. The substructure R represents one of a halogen, —SH, —SZ, —S—S-M-L-C(CF3)2(OH), wherein Z represents a thiol protecting group.
    Type: Application
    Filed: July 17, 2014
    Publication date: November 6, 2014
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventor: Arthur W. Snow
  • Patent number: 8809453
    Abstract: The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-)m, or (-alkylene-O—)m linkage, wherein m is 1-10.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: August 19, 2014
    Assignee: Nektar Therapeutics
    Inventors: Michael David Bentley, Xuan Zhao, Xiaoming Shen, William Dudley Battle, III
  • Publication number: 20140038826
    Abstract: A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol functional groups. The alkyne moiety, internal or terminal, may react with one or two thiols. Degradable monomers may be used to form degradable polymers.
    Type: Application
    Filed: January 27, 2012
    Publication date: February 6, 2014
    Applicant: The Regents of the University of Colorado, A Body Corporate
    Inventors: Kristi Anseth, Ben Fairbanks, Christopher Bowman
  • Patent number: 8618330
    Abstract: A hexafluorodimethylcarbinol terminated compound, method of making it, and a composition of matter are disclosed. The compound may have the formula (CF3)2C(OH)-L-M-R. The substructure L may be selected from an optionally substituted propenylene group (—CH2CH?CH—) and trimethylene group (—CH2CH2CH2—). The substructure M may be selected from a substituted or unsubstituted methylene chain, a substituted or unsubstituted oxyalkylene chain, and a silicon-containing chain or combination thereof. In one embodiment, M may be selected from —(CH2)n—, —(OCH2CH2)m—, and —(Si(CH3)2O)p—Si(CH3)2—(CH2)q—, wherein n is at least 1, e.g., n is up to 10, m can be at least 1, e.g., m is up to 10, p can be 0 and in one embodiment is from 1 to 10, and wherein q can be 1 and in one embodiment is from 1 to 12. The substructure R represents one of a halogen, —SH, —SZ, —S—S-M-L-C(CF3)2(OH), wherein Z represents a thiol protecting group.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: December 31, 2013
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventor: Arthur W Snow
  • Publication number: 20130327251
    Abstract: Novel tridentate-, bidentate-, and monodentate-based aromatic adsorbates including self-assembled monolayers (SAMs), especially, mixed multi-component SAMs, where the adsorbates comprise an aromatic ring including one head group or a plurality of dentate head groups and one tunable tail group or a plurality of tail groups and methods for making the same, and methods for using same, their use in the preparation of homogeneously mixed multi-component self-assembled monolayers (SAMs). The adsorbants and SAMs derived therefrom are ideally suited for biosensing, biosensing diagnostics, biological interfacial mimics, surface protections for nanoparticles, inert coatings for artificial implants, and corrosion-resistant coatings for microelectronics components.
    Type: Application
    Filed: March 7, 2013
    Publication date: December 12, 2013
    Applicant: THE UNIVERSITY OF HOUSTON SYSTEM
    Inventors: T. Randall Lee, Supachai Rittikulsittichai, Thomas Frank, Burapol Singhana
  • Publication number: 20130245204
    Abstract: Compounds of formula I, uses as crosslinking agents or curing agents thereof, and resins obtained by using the compounds as crosslinking agents.
    Type: Application
    Filed: July 8, 2011
    Publication date: September 19, 2013
    Applicant: CONNORA TECHNOLOGIES, INC.
    Inventors: Stefan J. Pastine, Bo Liang, Bing Qin
  • Publication number: 20130172224
    Abstract: In a cleaning liquid containing (A) an anticorrosive agent, and (B) a solvent, a compound represented by the following formula (1): wherein, R represents a substituent group; m is an integer of 1 to 3; and n is an integer of 0 to 3, wherein provided that m is 2 or 3, R may be the same or different; or the following formula (2): HS—(CH2)x—OH??(2) wherein, x is an integer of no less than 3, is used as the anticorrosive agent (A).
    Type: Application
    Filed: December 27, 2012
    Publication date: July 4, 2013
    Applicant: Tokyo Ohka Kogyo Co., Ltd.
    Inventor: Tokyo Ohka Kogyo Co., Ltd.
  • Patent number: 8440736
    Abstract: The present invention provides modified multifunctional thiol-ene monomers wherein one or more thiols are reacted with a Michael addition reactive double bond compound. The present invention further discloses photocurable thiol-ene formulations comprising thiol-ene monomers including the modified multifunctional thiols. The present invention further discloses photocurable thiol-ene formulations comprising thiol-ene monomers and Michael addition reactive double bond molecules and a Michael catalyst. The formulations of the present invention can be photocured to make films or coatings. In a further disclosure, the formulations, including those comprised of unmodified multifunctional thiols and multifunctional enes, are photocured to form films applied to non-flexible or flexible polymer or non-polymer substrates suitable for food packaging, electronic products, optical products and other applications and free-standing films.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: May 14, 2013
    Assignee: University of Southern Mississippi
    Inventors: Charles E. Hoyle, Sergei Nazarenko, Huanyu Wei
  • Publication number: 20130041183
    Abstract: The invention related to a process for the preparation of a bismercaptodiether by reacting a polysulfide with a monothiol in the presence of a base and to a process for the depolymerization of a polysulfide by reacting said polysulfide with a monothiol in the presence of a base. These processes enable the preparation of bismercaptodiethers without inorganic salt formation.
    Type: Application
    Filed: March 14, 2011
    Publication date: February 14, 2013
    Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
    Inventors: Rudolf Anthonius Maria Venderbosch, Hendrika Petronella Maria Verlaan-Hooft, Auke Gerardus Talma, Olaf Klobes, Ralf Tatas, Hendrik Jan Vos
  • Publication number: 20120329744
    Abstract: Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.
    Type: Application
    Filed: June 25, 2012
    Publication date: December 27, 2012
    Inventors: William A. Garland, Brian D. Frenzel
  • Publication number: 20120318317
    Abstract: An enormous order-dependent quantum enhancement of thermoelectric effects in the vicinity of higher-order interferences has been discovered in the transmission spectrum of nanoscale junctions. Significant enhancements due to both transmission nodes and resonances across such junctions are exemplified by single-molecule junctions (SMJs) based on 3,3?-biphenyl and polyphenyl ether (PPE). Thermoelectric devices employing such SMJs offer superior efficiency and performance. Moreover, the enhanced thermoelectric response is not limited to only SMJs, but may be obtained from any junction exhibiting transmission nodes or resonances arising from coherent electronic transport.
    Type: Application
    Filed: February 10, 2011
    Publication date: December 20, 2012
    Applicant: Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Charles A. Stafford, Justin P. Bergfield
  • Publication number: 20120315625
    Abstract: Cross-linked amphiphile constructs that form self-assembled monolayers (SAMs) on metal surfaces such as gold surfaces are disclosed. These new SAMs generate well packed and highly oriented monolayer films on gold surfaces. A method for using the SAMs in the fabrication of biomolecule sensors is also disclosed.
    Type: Application
    Filed: June 7, 2012
    Publication date: December 13, 2012
    Inventors: Patrick H. Dussault, Rebecca Y. Lai, Thomas Fisher, Anita J. Zaitouna
  • Publication number: 20120277332
    Abstract: One embodiment includes methods of adding two sulfonic acid groups to molecules having at least two cyclic groups.
    Type: Application
    Filed: April 29, 2011
    Publication date: November 1, 2012
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Thomas J. Chapaton, Tenneille Weston Capehart, Gail Capehart, Armand Soldera, Claude Spino, Riadh Zriba
  • Patent number: 8242217
    Abstract: It is an object of the present invention to provide an epoxy resin curing agent which has a favorable pot life and good storage stability as a curing agent for epoxy resins and from which an epoxy resin cured product having good water resistance and hardness is obtained through curing. The present invention is an epoxy resin curing agent containing a secondary or tertiary branched thiol compound having a substituent on a carbon atom at the ?-position to a thiol group, and is also an epoxy resin composition comprising a polyvalent epoxy compound and the epoxy resin curing agent.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: August 14, 2012
    Assignee: Showa Denko K.K.
    Inventors: Yoshifumi Urakawa, Hideo Miyata, Isao Yamagami, Katsumi Murofushi
  • Patent number: 8227517
    Abstract: Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: July 24, 2012
    Assignee: Tosk, Incorporated
    Inventors: William A. Garland, Brian D. Frenzel
  • Patent number: 8193290
    Abstract: A modified polyurethane including a lipid substituent from at least one urethane nitrogen and/or at least carbon atom of the modified polyurethane.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: June 5, 2012
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek
  • Publication number: 20120135823
    Abstract: An object of the present invention is to provide a golf ball having high resilience. The gist of the present invention resides in selecting an organic sulfur compound used for a golf ball rubber composition containing (a) a base rubber, (b) a co-crosslinking agent, (c) a crosslinking initiator, and (d) the organic sulfur compound from organic sulfur compounds having specific structures such that a sum of substituent constants of the substituents X in a structure represented by the following formula (4) is 0.2 or more and SP value of the structure represented by the following formula (4) is in a range from 19.0 (J/cm3) using the same.
    Type: Application
    Filed: October 20, 2011
    Publication date: May 31, 2012
    Inventors: Ayaka HIBI, Chiemi Mikura, Kazuhisa Fushihara, Yumi Kanemitsu, Mikio Yamada
  • Patent number: 8093435
    Abstract: A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after completion of the reaction. The reagent for organic synthesis reversibly changes from a liquid-phase state to a solid-phase state with changes in solution composition and/or solution temperature, and is for use in organic synthesis reactions. This reagent for organic syntheses facilitates process development. With the reagent, research on and development of, e.g., medicines through, e.g., compound library synthesis, etc. can be accelerated. It can hence contribute to technical innovations in the biochemical industry and chemical industry.
    Type: Grant
    Filed: February 19, 2007
    Date of Patent: January 10, 2012
    Assignee: JITSUBO Co., Ltd.
    Inventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono
  • Patent number: 8049042
    Abstract: To provide a resist polymer comprising, as a structural unit, an acid-decomposable unit having a structure represented by formula (1) or (2) which exhibits a small line edge roughness and produces little defects in DUV excimer laser lithography or the like.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: November 1, 2011
    Assignee: Mitsubishi Rayon Co., Ltd.
    Inventors: Hikaru Momose, Atsushi Ootake, Tadashi Nakamura, Akifumi Ueda
  • Patent number: 8044172
    Abstract: Cell-occlusive membrane, obtainable by reaction of at least two precursors in the presence of water. The first precursor A comprises a core and n chains each having a conjugated unsaturated group or a conjugated unsaturated bond, and the second precursor B comprises a core and m chains each having a thiol group, wherein m is greater than or equal to 2, n is greater than or equal to 2, and m+n is greater than or equal to 5. The reaction forms a three dimensional network with crosslinking-points. The adjacent crosslinking-points are connected by a chain having less than 600 atoms.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: October 25, 2011
    Assignee: Straumann Holding AG
    Inventor: Aaldert Rens Molenberg
  • Publication number: 20110245486
    Abstract: The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups.
    Type: Application
    Filed: April 29, 2009
    Publication date: October 6, 2011
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Guenter Billen, Wendelin Frick, John Patrick Larkin, Guy Lemaitre, Francoise Bendetti, Philippe Boffelli, Jean-Yves Godard, Christian Masson, Veronique Crocq, Sylvaine Lafont, Jos Hulshof
  • Publication number: 20110207967
    Abstract: Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesised rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer of from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst.
    Type: Application
    Filed: September 24, 2009
    Publication date: August 25, 2011
    Inventors: Lars Skattebol, Inger Aukrust, Marcel Sandberg
  • Publication number: 20110160393
    Abstract: The present invention provides a multi-branched polyalkylene glycol polymer useful for various applications, especially for an admixture for cement, a dispersant, admixture for cement, and cement composition each comprising the same, a thiol compound having a polyalkylene glycol chain useful for materials and the like of the polymer, and a method for easily and effectively producing the multi-branched polyalkylene glycol polymer and the thiol compound having a polyalkylene glycol chain at low cost. The multi-branched polymer comprises: a polyalkylene glycol chain; a residue of a compound having three or more active hydrogen atoms; and a polymer portion having a constitutional unit derived from a vinyl monomer component, one end of the polyalkylene glycol chain bonding to the residue, and a terminal oxygen atom of at least one of the other ends of the polyalkylene glycol chain bonding to a main chain end of the polymer portion directly or via an organic residue.
    Type: Application
    Filed: September 8, 2009
    Publication date: June 30, 2011
    Inventors: Noboru Sakamoto, Tsutomu Yuasa
  • Publication number: 20110054202
    Abstract: A hexafluorodimethylcarbinol terminated compound, method of making it, and a composition of matter are disclosed. The compound may have the formula (CF3)2C(OH)-L-M-R. The substructure L may be selected from an optionally substituted propenylene group (—CH2CH?CH—) and trimethylene group (—CH2CH2CH2—). The substructure M may be selected from a substituted or unsubstituted methylene chain, a substituted or unsubstituted oxyalkylene chain, and a silicon-containing chain or combination thereof. In one embodiment, M may be selected from —(CH2)n—, —(OCH2CH2)m—, and —(Si(CH3)2O)p—Si(CH3)2—(CH2)q—, wherein n is at least 1, e.g., n is up to 10, m can be at least 1, e.g., m is up to 10, p can be 0 and in one embodiment is from 1 to 10, and wherein q can be 1 and in one embodiment is from 1 to 12. The substructure R represents one of a halogen, —SH, —SZ, —S—S-M-L-C(CF3)2(OH), wherein Z represents a thiol protecting group.
    Type: Application
    Filed: August 27, 2009
    Publication date: March 3, 2011
    Applicant: The Government of the US, as represented by the Secretary of the Navy
    Inventor: Arthur W. Snow
  • Publication number: 20110033560
    Abstract: The present invention relates to the use of a preparation comprising a substance that is capable of binding acetaldehyde, and to the use of a filter that is attached to a tobacco product to reduce tobacco and/or alcohol dependence.
    Type: Application
    Filed: September 12, 2008
    Publication date: February 10, 2011
    Applicant: BIOHIT OYJ
    Inventors: Osmo Suovaniemi, Mikko Salaspuro, Ville Salaspuro, Martti Marvola
  • Patent number: 7872072
    Abstract: The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-)m, or (-alkylene-O—)m linkage, wherein m is 1-10.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: January 18, 2011
    Assignee: Nektar Therapeutics
    Inventors: Michael David Bentley, Xuan Zhao, Xiaoming Shen, William Dudley Battle, III
  • Publication number: 20100286073
    Abstract: The present invention relates to compounds, as well as to compositions, methods and kits comprising such compounds, for use in the treatment or prophylaxis of fibromyalgia, chronic fatigue syndrome, myofascial pain syndrome, Gulf War syndrome and related conditions, wherein the compound is a fatty acid oxidation inhibitor and/or a carbohydrate oxidation activator.
    Type: Application
    Filed: October 3, 2008
    Publication date: November 11, 2010
    Inventor: Paul JENKINS
  • Publication number: 20100160645
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Application
    Filed: May 29, 2009
    Publication date: June 24, 2010
    Applicant: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff
  • Patent number: 7741427
    Abstract: The present invention relates to a cell-occlusive membrane, obtainable by reaction of at least two precursors in the presence of water. The first precursor A comprises a core and n chains each having a conjugated unsaturated group or a conjugated unsaturated bond, and the second precursor B comprises a core and m chains each having a thiol group, wherein m is greater than or equal to 2, n is greater than or equal to 2, and m+n is greater than or equal 5. The reaction forms a three dimensional network with crosslinking-points. The adjacent crosslinking-points are connected by a chain having less than 600 atoms.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: June 22, 2010
    Assignee: Straumann Holding AG
    Inventor: Aaldert Rens Molenberg
  • Patent number: 7655474
    Abstract: A method of making a nanoclusters functionalized with a single DNA strand comprising the steps of providing nanoclusters, combining said nanoclusters with thiolated DNA, incubating said nanoclusters and thiolated DNA mixture, combining said mixture with a solution comprising ethanol and dichloromethane; separating said mixture into an aqueous phase and an organic phase, mixing said aqueous phase with a solution comprising dicholormethane and NaCl, and separating the mixture into an aqueous phase and an organic phase; wherein said organic phase comprises said nanoclusters functionalized with a single DNA strand. Further, provided is a nanocluster functionalized with a single DNA strand comprising a nanocluster, said nanocluster being functionalized with a single DNA strand, said DNA strand having a length of about 10 to about 50 bases.
    Type: Grant
    Filed: April 3, 2006
    Date of Patent: February 2, 2010
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Sulay Jhaveri, Mario Ancona, Edward E Foos, Eddie L Chang
  • Patent number: 7638655
    Abstract: A method for producing 4-(methylthio)butane-1,2-diol which comprises reacting 3-butene-1,2-diol with methanethiol in the presence of at least one nitrogen-containing compound selected from a nitrogen-containing aromatic compound and a tertiary amine compound and a carboxylic acid compound.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: December 29, 2009
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Koji Hagiya
  • Patent number: 7622613
    Abstract: The present invention relates to a thiol compound represented by formula (1): wherein R1, R2 and n have the same meanings as in the specification, method for producing the compound, and to a photosensitive composition and a black matrix resist composition using the same which have high sensitivity and excellent property of retaining a line width in fine line patterns at the time of alkaline development, that is, being excellent in development latitude.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: November 24, 2009
    Assignee: Showa Denko K.K.
    Inventors: Hirotoshi Kamata, Mina Onishi, Katsumi Murofushi
  • Publication number: 20090259075
    Abstract: A method for producing 4-(methylthio)butane-1,2-diol which comprises reacting 3-butene-1,2-diol with methanethiol in the presence of at least one nitrogen-containing compound selected from a nitrogen-containing aromatic compound and a tertiary amine compound and a carboxylic acid compound.
    Type: Application
    Filed: August 11, 2006
    Publication date: October 15, 2009
    Inventor: Koji Hagiya
  • Publication number: 20090197201
    Abstract: The present invention relates to the use of end groups Y, where Y stands for (formula I), where Rf stands for CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)r—, [CF3—(CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B stands for a single bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O), C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R stands for alkyl having 1 to 4 C atoms, b stands for 0 or 1 and c stands for 0 or 1, q stands for 0 or 1, where at least one radical from b and q stands for 1, and r stands for 0, 1, 2, 3, 4 or 5, as end group in surface-active compounds, to corresponding novel compounds, and to processes for the preparation of these compounds.
    Type: Application
    Filed: July 2, 2007
    Publication date: August 6, 2009
    Inventors: Wolfgang Hierse, Nikolai (Mykola) Ignatyev, Martin Seidel, Elvira Montenegro, Peer Kirsch, Andreas Bathe
  • Patent number: 7527652
    Abstract: Mixtures of (A) from 55 to 65 mol % of erythro-dithiol of formula erythro-IV: and (B) from 35 to 45 mol % of threo-dithiol of formula threo-IV or threo-IV?: and their corresponding alkali metal salts and ammonium salts, are useful for treating animal hides.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: May 5, 2009
    Assignee: BASF Aktiengesellschaft
    Inventors: Holger Buehler, Joaquim Henrique Teles, Gunther Pabst, Tilman Luedecke Taeger
  • Patent number: 7507828
    Abstract: One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: March 24, 2009
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Bin Chen
  • Patent number: 7476766
    Abstract: Compounds according to formula (I) wherein Z is S, SO, or SO2, may be prepared by a process that includes charging to a reactor hydrogen sulfide and an alkyl glycidyl ether according to formula (III), in the presence of a base. The compounds may also be prepared by contacting an alkoxychlorohydrin according to formula (II) with a sulfide source.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: January 13, 2009
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Andrew Wilson Wang, Kevin Rodney Lassila, Michael Edward Ford, Joseph Richard Krock, Nancy Mary Martin, Ge Grace Zhang
  • Publication number: 20080274052
    Abstract: The present invention relates to methods and reagents for [18F]-fluorination, particularly of peptides. The resultant 18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET). Thus, a compound of formula 18F-(Linker)-SH, such as a compound of formula (IV), (V), or (VI): may be reacted with an activated peptide as a means for 18F-labelling.
    Type: Application
    Filed: April 7, 2008
    Publication date: November 6, 2008
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Alan Cuthbertson, Magne Solbakken, Joseph Maduabuchi Arukwe, Hege Karlsen
  • Publication number: 20080227978
    Abstract: A process for converting a carbonyl group within a substrate to a chiral alcohol moiety comprising reacting the carbonyl containing substrate with an organoaluminium reagent in the presence of a Group 5-12 transition metal based catalyst which is complexed with a chiral ligand; novel chiral ligands and organoluminium reagents, a chiral ligand or organoaluminium reagent for use in the process.
    Type: Application
    Filed: January 26, 2006
    Publication date: September 18, 2008
    Inventor: Simon Woodward
  • Patent number: 7411097
    Abstract: By resolving objections in the prior art, provided are a novel copolymer suitable as a coating polymers which is excellent in adhesion to a substrate and can be used suitably as the polymer for the coating film having durability against pattern collapse in the finer pattern formation for progressed lithography technology and a method for producing the copolymer, as well as a novel thiol compound useful as a chain transfer agent in the production of the copolymer. The novel thiol compound of the present invention has the structure represented by the formula (1); wherein R1 is a bivalent substituent selected from linear, branched or cyclic saturated hydrocarbon having 1 to 15 carbon atoms.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: August 12, 2008
    Assignee: Maruzen Petrochemical Co. Ltd.
    Inventors: Takanori Yamagishi, Takahito Mita
  • Patent number: 7270791
    Abstract: An improved angled annular deflector for a gas-phase polymerization reactor and improved method for delivery of a stream of polymerizable fluid to a gas-phase polymerization reator. The angled annular deflector has an outer surface with a conical shape, an inner surface, and an inner cavity along a central axis, said cavity open at both ends, the inner surface having a first end and a second end, and the first end of the inner surface mated to the apex end of the outer surface: and an upper surface mated to the base end of the outer surface and to the second end of the inner surface; wherein the outer surface, the inner surface, and the upper surface form a substantially closed chamber. The angled annular deflector being adapted to associate with a cone-shaped bottom portion of a fluidized bed polymerization reactor vessel.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: September 18, 2007
    Assignee: Univation Technologies, LLC
    Inventors: Mark Bradley Davis, Wesley James Perry
  • Patent number: 7230138
    Abstract: Compounds according to formula (I) wherein Z is S, SO, or SO2, may be prepared by a process that includes charging to a reactor hydrogen sulfide and an alkyl glycidyl ether according to formula (III), in the presence of a base.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: June 12, 2007
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Andrew Wilson Wang, Kevin Rodney Lassila, Michael Edward Ford, Joseph Richard Krock, Nancy Mary Martin, Ge Grace Zhang
  • Patent number: 7193114
    Abstract: The present invention attaches a molecule that contains a hydroxyl group (OH) attached to a carbon chain which is attached to a coordinating atom or atoms, the acidity of which is greater than that of silica (i.e., pKA <10). The condensation is achieved by mixing silica gel, appropriate amount of ligand, and a drop of conc. sulfuric acid in toluene in a flask attached to a Dean-Stark tube. Heating of the mixture is continued until the amount of water, obtained by azeotropic distillation and condensation, reaches a constant value. Toluene is filtered off, and recycled. The supported ligand is dried under reduced pressure to remove residual toluene. The composite (ligand attached to silica) can then be used by batch or column method to remove heavy metal ions from aqueous solution.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: March 20, 2007
    Assignee: University of South Florida
    Inventors: Dean F. Martin, Craig A. Bowe
  • Patent number: 7189867
    Abstract: A compound having the formula CF3—CH(OH)—CH2—(L)n—CH2—SH or a disulfide thereof. Each L is substituted or unsubstituted methylene, substituted or unsubstituted oxyalkylene, and alkyl-substituted or unsubstituted siloxanylene. The compound is free of carboxysilane linkages. The value of n is a positive integer. A metal surface having the group CF3—CH(OH)—CH2—(L)n—CH2—S— bound thereto. A method of making CF3—CH(OH)—CH2—(L)n—CH2—SH by: reacting OHC—CH2—(L)n—CH2—X with (trifluoromethyl)trialkylsilane to form CF3—CH(OH)—CH2—(L)n—CH2—X; reacting the intermediate with a thiocarbonyl compound to form an adduct; and hydrolyzing the adduct followed by protonation. X is a halogen.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: March 13, 2007
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: James H Wynne, Arthur W Snow
  • Patent number: 6987132
    Abstract: The invention provides novel tetradentate enediyne ligands that are themselves thermally stable, yet react at about room temperature or slightly higher upon addition of metal ions or under photothermal conditions. In another aspect of the invention, a method of treating a disorder in a mammal comprising administering a therapeutically effective amount of a compound or composition is provided. In addition, the free ligand can be delivered to the mammal prior to complexation to metals, such that the ligand is exposed to a metal in the body and forms a metal complex in vivo. Furthermore, a metal complex of the invention can be administered to the mammal such that the complex exchanges the first metal center with another endogenous metal in order to form a second metal complex in vivo. The second metal complex is capable of forming a benzenoid diradical under physiological conditions and/or under photothermal conditions.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: January 17, 2006
    Assignee: Advanced Research and Technology Institute, Inc.
    Inventors: Jeffrey M. Zaleski, Diwan Singh Rawat
  • Patent number: 6894194
    Abstract: In a process to make dithiodiglycol by oxidation of ?-mercaptoethanol with sulfur, an improved product is recovered when a 1-10 mol % excess of ?-mercaptoethanol is used and hydrogen sulfide is removed by vacuum or nitrogen sparge. A typical product contains 88.1 mol % (92.0 wt %) dithiodiglycol, 2.3 mol % (2.9 wt %) trithiodiglycol and 9.6 mol % (5.1 wt %) unreacted ?-mercaptoethanol. Reaction of this product with 35 to 50 wt % solution hydrogen peroxide reduces residual ?-mercaptoethanol to less than 0.02 wt % mercaptan. Residual water of about 3.6 wt % after hydrogen peroxide treatment is reduced to less than 1 wt % by vacuum stripping and/or nitrogen sparge or with a wiped film evaporator.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: May 17, 2005
    Assignee: Chevron Phillips Chemical Company
    Inventors: Kenneth E. Inkrott, Michael S. Matson, Alex Pauwels