Benzene Ring Containing Patents (Class 568/67)
  • Publication number: 20140292281
    Abstract: A predoping material is used for an alkali metal ion electric storage device and is represented by Formula (1): R?SM)n??(I) where M represents lithium or sodium; n represents an integer of 2 to 6; and R represents an aliphatic hydrocarbon, optionally substituted aromatic hydrocarbon, or optionally substituted heterocycle having 1 to 10 carbon atoms).
    Type: Application
    Filed: March 26, 2014
    Publication date: October 2, 2014
    Applicant: FUJI JUKOGYO KABUSHIKI KAISHA
    Inventors: Yasuyuki KIYA, Takahito SAKURABA, Satoru KUDO, Ken BABA
  • Publication number: 20130172224
    Abstract: In a cleaning liquid containing (A) an anticorrosive agent, and (B) a solvent, a compound represented by the following formula (1): wherein, R represents a substituent group; m is an integer of 1 to 3; and n is an integer of 0 to 3, wherein provided that m is 2 or 3, R may be the same or different; or the following formula (2): HS—(CH2)x—OH??(2) wherein, x is an integer of no less than 3, is used as the anticorrosive agent (A).
    Type: Application
    Filed: December 27, 2012
    Publication date: July 4, 2013
    Applicant: Tokyo Ohka Kogyo Co., Ltd.
    Inventor: Tokyo Ohka Kogyo Co., Ltd.
  • Publication number: 20130150608
    Abstract: This invention is directed to an improvement in the process for the production of alkylaromatic compounds that results in lower levels of residual unreacted materials in the final product. This invention comprises: 1) alkylation of an aromatic compound with an alkylating agent and a catalyst to produce an effluent stream comprising an alkylaromatic compound and unreacted materials; 2) heating the effluent stream; 3) stripping the effluent stream in a stripping device in the presence of steam; 4) separating a stripping stream from the stripping device, the stripping stream rich in unreacted materials; and 5) separating a product stream from the stripping device, the product stream rich in alkylated aromatic compound.
    Type: Application
    Filed: December 13, 2011
    Publication date: June 13, 2013
    Inventors: Beth A. Winsett, James I. Arnett, II, Kenwyn M. Leger, Brady A. Compton
  • Publication number: 20130150607
    Abstract: This invention is directed to a new process for making an alkylaromatic compound. In an embodiment of this invention, the process is directed to selective synthesizing an alkylaromatic compound comprising a high amount of dialkylate product. In general, this process involves contacting at least one alkylatable aromatic compound with an alkylating agent and a catalyst under suitable reaction conditions such that the resulting reactor effluent prior to any stripping step may be characterized by a dialkylate product content of at least 44 wt % and a trialkylate and higher polyalkylate product content of no more than 20 wt %. The alkylaromatic compounds produced have excellent thermal and oxidative stabilities, good additive solvency, and improved seal compatibility while maintaining good VI and low temperature properties. They are useful as lubricant basestocks and lubricant additives.
    Type: Application
    Filed: December 7, 2011
    Publication date: June 13, 2013
    Inventor: Beth A. WINSETT
  • Patent number: 8440736
    Abstract: The present invention provides modified multifunctional thiol-ene monomers wherein one or more thiols are reacted with a Michael addition reactive double bond compound. The present invention further discloses photocurable thiol-ene formulations comprising thiol-ene monomers including the modified multifunctional thiols. The present invention further discloses photocurable thiol-ene formulations comprising thiol-ene monomers and Michael addition reactive double bond molecules and a Michael catalyst. The formulations of the present invention can be photocured to make films or coatings. In a further disclosure, the formulations, including those comprised of unmodified multifunctional thiols and multifunctional enes, are photocured to form films applied to non-flexible or flexible polymer or non-polymer substrates suitable for food packaging, electronic products, optical products and other applications and free-standing films.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: May 14, 2013
    Assignee: University of Southern Mississippi
    Inventors: Charles E. Hoyle, Sergei Nazarenko, Huanyu Wei
  • Patent number: 8227517
    Abstract: Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: July 24, 2012
    Assignee: Tosk, Incorporated
    Inventors: William A. Garland, Brian D. Frenzel
  • Patent number: 8049042
    Abstract: To provide a resist polymer comprising, as a structural unit, an acid-decomposable unit having a structure represented by formula (1) or (2) which exhibits a small line edge roughness and produces little defects in DUV excimer laser lithography or the like.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: November 1, 2011
    Assignee: Mitsubishi Rayon Co., Ltd.
    Inventors: Hikaru Momose, Atsushi Ootake, Tadashi Nakamura, Akifumi Ueda
  • Publication number: 20110129762
    Abstract: The present invention features a method for increasing hydrophilic properties of crystalline carbon using a surface modifier and a method for preparing a Pt/C catalyst using the same. In certain preferred embodiments, the present invention features a method for increasing hydrophilic properties of crystalline carbon having water repellency by forming ?-? interaction between the surface of the crystalline carbon and a surface modifier and a method for preparing a catalyst by supporting platinum (Pt) on the crystalline carbon having increased hydrophilic property. The Pt/C catalyst prepared by the methods of the present invention is useful for the preparation of electrode materials for fuel cells.
    Type: Application
    Filed: March 31, 2010
    Publication date: June 2, 2011
    Applicants: HYUNDAI MOTOR COMPANY, KIA MOTORS CORPORATION, Industry-Academic Cooperation Foundation, Younsei University
    Inventors: Ki Sub Lee, Bumwook Roh, Han Sung Kim, Hyung-Suk Oh
  • Patent number: 7829155
    Abstract: The present invention provides a new monomer and methods of using the monomer to fabricate robust polymer surface coatings with controlled thicknesses between 1 and 5 nanometers. The coatings are composed of a new material containing polymerized monomers of 4-vinylbenzenepropanethiol. The polymer surface coating may be applied to metal and silicon. The method includes exposing a metal substrate to a solution of the monomer in hexanes in order to deposit a monolayer of the monomer onto the metal surface. The substrate is then irradiated with ultraviolet radiation in order to graft a thin polymer coating onto the surface. The procedure can be repeated in order to control the thickness of the coating between about 1 nm and 5 nm. Alternatively, thermally initiated polymerization or deposition of partially oligomerized monomers onto the surface provides nanothin coatings with identical performance.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: November 9, 2010
    Assignee: The University of Memphis Research Foundation
    Inventors: Evgueni Pinkhassik, Larry Todd Banner, Benjamin T. Clayton
  • Publication number: 20100137600
    Abstract: This invention describes reagent precursors and methods for chemical and biochemical reactions. These reagent precursors that can be activated in solution upon irradiation to generate reagents required for the subsequent chemical reactions. Specifically, photogenerated reagents (PGR) are useful for controlling parallel combinatorial synthesis and various chemical and biochemical reactions.
    Type: Application
    Filed: May 18, 2009
    Publication date: June 3, 2010
    Inventors: Xiaolian Gao, Zhuo Xiaochruan, Wu Yao, Jean-Phillipe Pollols
  • Patent number: 7714032
    Abstract: The present invention relates to a thiol compound represented by formula (1): wherein R1, R2 and n have the same meanings as in the specification, method for producing the compound, and to a photosensitive composition and a black matrix resist composition using the same which have high sensitivity and excellent property of retaining a line width in fine line patterns at the time of alkaline development, that is, being excellent in development latitude.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: May 11, 2010
    Assignee: Showa Denko K.K.
    Inventors: Hirotoshi Kamata, Mina Onishi, Katsumi Murofushi
  • Publication number: 20100029876
    Abstract: A polymerization accelerator includes a specific thiol compound. A curable composition of excellent thermal stability contains the polymerization accelerator. A cured product is obtained from the curable composition. The polymerization accelerator includes a thiol compound having two or more groups represented by Formula (1) below: wherein R1 is a hydrogen atom or a C1-10 alkyl group, and m is an integer of 0, 1 or 2.
    Type: Application
    Filed: June 13, 2007
    Publication date: February 4, 2010
    Inventors: Hideo Miyata, Haruhiko Ikeda, Katsumi Murofushi, Yotaro Hattori, Katsuro Urakawa
  • Patent number: 7648843
    Abstract: This invention pertains to a surface ligand; preparation of the ligand; colloidal nanoparticle, such as quantum dot bearing one or more of the ligand; and a bioconjugate characterized by a nanoparticle bearing one or more of the ligand conjugated to a biomolecule. The ligand is characterized by the presence of a first module containing atoms that can attach to an inorganic surface; a second module that imparts water-solubility to the ligand and to the inorganic surface that may be attached to the ligand; and a third module that contains a functional group that can, directly or indirectly, conjugate to a biomolecule. Order of the modules can be different and other modules and groups can be on the ligand. Preparation of the ligand includes the steps of reacting a compound having atoms that can attach to an inorganic surface with a water-solubilizing compound that imparts the property of water-solubility to the ligand and the inorganic surface to which it may be attached and purification thereof.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: January 19, 2010
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Harry Tetsuo Uyeda, Hedi M Mattoussi, Igor L Medintz
  • Publication number: 20100010267
    Abstract: The present invention relates to a method for producing thiols through addition of hydrogen sulfide onto at least one unsaturated terpene, where the reaction is carried out in the presence of at least one organic ion exchanger, and to the use of thiols derived from terpinolene as molar mass regulator in the polymerization of monomers.
    Type: Application
    Filed: October 15, 2007
    Publication date: January 14, 2010
    Applicant: BASF SE
    Inventors: Patrick Deck, Oliver Birkert
  • Patent number: 7622613
    Abstract: The present invention relates to a thiol compound represented by formula (1): wherein R1, R2 and n have the same meanings as in the specification, method for producing the compound, and to a photosensitive composition and a black matrix resist composition using the same which have high sensitivity and excellent property of retaining a line width in fine line patterns at the time of alkaline development, that is, being excellent in development latitude.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: November 24, 2009
    Assignee: Showa Denko K.K.
    Inventors: Hirotoshi Kamata, Mina Onishi, Katsumi Murofushi
  • Patent number: 7507828
    Abstract: One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: March 24, 2009
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Bin Chen
  • Patent number: 7361516
    Abstract: This invention pertains to a surface ligand; preparation of the ligand; colloidal nanoparticle, such as quantum dot bearing one or more of the ligand; and a bioconjugate characterized by a nanoparticle bearing one or more of the ligand conjugated to a biomolecule. The ligand is characterized by the presence of a first module containing atoms that can attach to an inorganic surface; a second module that imparts water-solubility to the ligand and to the inorganic surface that may be attached to the ligand; and a third module that contains a functional group that can, directly or indirectly, conjugate to a biomolecule. Order of the modules can be different and other modules and groups can be on the ligand. Preparation of the ligand includes the steps of reacting a compound having atoms that can attach to an inorganic surface with a water-solubilizing compound that imparts the property of water-solubility to the ligand and the inorganic surface to which it may be attached and purification thereof.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: April 22, 2008
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Harry T. Uyeda, Hedi Mattoussi, Igor L. Medintz
  • Patent number: 7312266
    Abstract: Organic thiol compounds based on pentaerythritol and dipentaerythritol are described herein. More specifically, the compounds of the present invention are mixed esters of pentaerythritol and dipentaerythritol having at least one sulfhydryl group and preferably a plurality of sulfhydryl groups as well as at least one non-thiol-containing group. The organic thiol compounds are utilized to plasticize and/or heat stabilize halogen-containing polymer compositions especially poly(vinyl chloride) compositions. The compositions are substantially free or free of metal-based stabilizers, Lewis acids and terpenes. The compounds of the present invention are ideally utilized in polymers normally susceptible to deterioration and color change which can occur during processing of the polymer or exposure of the polymer to certain environments and surprisingly also serve as excellent plasticizers.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: December 25, 2007
    Assignee: The College of William and Mary
    Inventors: William Herbert Starnes, Jr., Bin Du
  • Patent number: 7271280
    Abstract: A process for preparing an optically active biaryl compound the formula (4): which comprises reacting an aromatic sulfonic acid ester compound of the formula (1): with an organic boron compound of the formula (2): at 70° C. or below in the presence of a nickel catalyst and a base. The biaryl compounds produced using this process possess a high optical purity and are useful as intermediates for medicaments, agrochemicals, etc.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: September 18, 2007
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hiroshi Ueda, Isao Kurimoto
  • Patent number: 7268242
    Abstract: Chelating ligand precursors for the preparation of olefin metathesis catalysts are disclosed. The resulting catalysts are air stable monomeric species capable of promoting various metathesis reactions efficiently, which can be recovered from the reaction mixture and reused. Internal olefin compounds, specifically beta-substituted styrenes, are used as ligand precursors. Compared to terminal olefin compounds such as unsubstituted styrenes, the beta-substituted styrenes are easier and less costly to prepare, and more stable since they are less prone to spontaneous polymerization. Methods of preparing chelating-carbene metathesis catalysts without the use of CuCl are disclosed. This eliminates the need for CuCl by replacing it with organic acids, mineral acids, mild oxidants or even water, resulting in high yields of Hoveyda-type metathesis catalysts.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: September 11, 2007
    Assignee: Materia, Inc.
    Inventors: Richard L. Pederson, Jason K. Woertink, Christopher M. Haar, David E. Gindelberger, Yann Schrodi
  • Patent number: 7217841
    Abstract: Elastomers which have excellent stability to prevent oxidative, thermal, dynamic, light-induced and/or ozone-induced degradation comprise, as stabilizers, at least one compound of the formula I [R—S(?O)m—CH2—CH(OH)—CH2]n—N(R1)2-n—R2, ??(I) in which R is C4–C20alkyl, hydroxyl-substituted C4–C20alkyl; phenyl, benzyl, ?-methylbenzyl, ?,?-dimethylbenzyl, cyclohexyl or —(CH2)qCOOR3, and, if m is 0, R may additionally be and, if n is 1 and R4 is hydrogen, R may additionally be R2—R1N—CH2—CH(OH)—CH2—S(?O)m—(CH2)x— or R2—R1N—CH2—CH(OH)—CH2—S(?O)m—CH2—CH2—(O—CH2—CH2)y—, R1 is hydrogen, cyclohexyl or C3–C12alkyl, R2 is R3 is C1-C18alkyl, R4 is hydrogen or —CH2—CH(OH)—CH2—S(?O)m—R, X is C1–C8alkyl, Y is C1–C8alkyl, m is 0 or 1, n is 1 or 2, q is 1 or 2, x is from 2 to 6, and y is 1 or 2. The compounds of the formula I are also suitable as stabilizers for elastomers to prevent contact discoloration of substrates coming into contact with elastomers.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: May 15, 2007
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Hans-Rudolf Meier, Gerrit Knobloch, Samuel Evans
  • Patent number: 7173156
    Abstract: A method of thioacetate deprotection by providing a compound of the formula R1—S—CO—R2, and reacting the compound with a quaternary ammonium cyanide salt in the presence of a protic solvent in an inert atmosphere to convert the compound to a product of the formula R1—SH. R1 is an organic group in which the bonding to sulfur is through a saturated carbon, and R2 is an aliphatic group.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: February 6, 2007
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Brian T Holmes, Arthur W Snow
  • Patent number: 6927247
    Abstract: Organic thiol compounds including mercaptophenylcarboxylates are disclosed which can be utilized to plasticize and/or stabilize halogen-containing polymer compositions, especially poly(vinyl chloride) compositions. Compounds of the present invention are utilized in polymers normally susceptible to deterioration and color change, which typically occurs during processing of the polymer or exposure to certain environments.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: August 9, 2005
    Assignee: The College of William and Mary
    Inventors: William Herbert Starnes, Jr., Soungkyoo Kim
  • Publication number: 20040158093
    Abstract: A process for preparing an optically active biaryl compound the formula (4): 1
    Type: Application
    Filed: February 10, 2004
    Publication date: August 12, 2004
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Hiroshi Ueda, Isao Kurimoto
  • Publication number: 20040158074
    Abstract: A class of substituted biphenyl compounds is described for use in treating inflammation and inflammation-related disorders.
    Type: Application
    Filed: January 13, 2004
    Publication date: August 12, 2004
    Applicant: G.D. Searle & Co.
    Inventors: David B. Reitz, James J. Li, Monica B. Norton
  • Patent number: 6740782
    Abstract: The invention aims at providing novel sulfur compounds, molecular compounds containing the same as the component compound, and so on. The above aim is achieved by using sulfur compounds of the general formula (I) wherein Rs are each independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted aryl, chloro, or bromo; m is an integer of 0, 1, or 2; and Z is a group represented by any of the general formulae (II) to (V) (wherein R and m are each as defined above; W is hydrogen or C1-6 alkyl; and Y is a direct bond, C1-3 alkylene, or phenylene).
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: May 25, 2004
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Ryu Sato, Hiroshi Suzuki
  • Publication number: 20040030135
    Abstract: A process for the preparation of thiophenols of formula (I) wherein n is an integer from 1 to 5 and R is hydrogen, alkyl, hydroxyalkyl, alkylamino, dialkylamino, alkenyl, alkynyl, alkoxy, alkylthio, phenyl, naphthyl, phenoxy, phenylthio, halogen, hydroxy, mercapto, carboxyl, sulfo or heterocyclyl, by reacting phenyldiazonium salts of formula (II) wherein n and R are as defined and X is halogen or hydrogen sulfate, with sulfur at elevated temperature in the presence of an aqueous base and isolating the compounds of formula (I).
    Type: Application
    Filed: April 9, 2003
    Publication date: February 12, 2004
    Inventors: Gottfried Seifert, Bernhard Urwyler
  • Publication number: 20040014950
    Abstract: New ligands and compositions with bridged bis-aromatic ligands are disclosed that catalyze the polymerization of monomers into polymers. These catalysts with metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, propylene or styrene. The catalysts also polymerize propylene into isotactic polypropylene.
    Type: Application
    Filed: April 23, 2003
    Publication date: January 22, 2004
    Applicant: Symyx Technologies, Inc.
    Inventors: Thomas R. Boussie, Oliver Brummer, Gary M. Diamond, Christopher Goh, Anne M. LaPointe, Margaret K. Leclerc, James A. W. Shoemaker
  • Publication number: 20040006235
    Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.
    Type: Application
    Filed: March 17, 2003
    Publication date: January 8, 2004
    Applicant: Merck Patent GmbH
    Inventors: Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
  • Patent number: 6667421
    Abstract: This invention relates to a process for the production of an aryl thiol, which comprises hydrogenating an aryl sulfonyl chloride in a solvent in the presence of a palladium catalyst and a base whose conjugate acid has a pKa of about 2 or greater, wherein the base is selected from the group consisting of ionic bases soluble in water and tertiary amines soluble in the solvent, the tertiary amines not having a methyl group attached to the amine nitrogen.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: December 23, 2003
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Stephen E. Jacobson
  • Publication number: 20030130358
    Abstract: The invention aims at providing novel sulfur compounds, molecular compounds containing the same as the component compound, and so on. The above aim is achieved by using sulfur compounds of the general formula (I) wherein Rs are each independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted aryl, chloro, or bromo; m is an integer of 0, 1, or 2; and Z is a group represented by any of the general formulae (II) to (V) (wherein R and m are each as defined above; W is hydrogen or C1-6 alkyl; and Y is a direct bond, C1-3 alkylene, or phenylene).
    Type: Application
    Filed: September 12, 2002
    Publication date: July 10, 2003
    Inventors: Ryu Sato, Hiroshi Suzuki
  • Publication number: 20030119054
    Abstract: A substrate comprises a surface, and a plurality of moieties, on at least a portion of the surface.
    Type: Application
    Filed: August 7, 2001
    Publication date: June 26, 2003
    Inventors: Milan Mrksich, Christian Hodneland
  • Publication number: 20030055290
    Abstract: This invention relates to a process for the production of an aryl thiol, which comprises hydrogenating an aryl sulfonyl chloride in a solvent in the presence of a palladium catalyst and a base whose conjugate acid has a pKa of about 2 or greater, wherein the base is selected from the group consisting of ionic bases soluble in water and tertiary amines soluble in the solvent, the tertiary amines not having a methyl group attached to the amine nitrogen.
    Type: Application
    Filed: August 28, 2002
    Publication date: March 20, 2003
    Inventor: Stephen E Jacobson
  • Publication number: 20030013746
    Abstract: The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions.
    Type: Application
    Filed: August 8, 2002
    Publication date: January 16, 2003
    Applicant: University of Kansas Medical Center.
    Inventors: Billy G. Hudson, Parvin Todd, Raja Gabriel Khalifah, Aaron Ashley Booth
  • Patent number: 6500988
    Abstract: The invention relates to a particularly advantageous method for producing aryl thiols through the catalytic hydrogenation of diaryldisulphides. According to the invention, the hydrogenation is carried out in a basic alcoholic medium.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: December 31, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Friedrich-Wilhelm Ullrich, Helmut Fiege
  • Publication number: 20020137971
    Abstract: The present invention relates to methods for production of arylsulfides wherein an aromatic compound is reacted with elemental sulfur in the presence of solid acid catalyst. The solid acid catalyst can be a zeolite. The methods are useful for producing alkylated diphenylsulfides from aromatic compounds and elemental sulfur.
    Type: Application
    Filed: October 9, 2001
    Publication date: September 26, 2002
    Inventors: Margaret M. Wu, Philip Trotto, Shifang Luo, Jose G. Santiesteban, Hye Kyung C. Timken, Sandeep S. Dhingra, Simon C. Weston, Richard T. Spissell
  • Publication number: 20020052530
    Abstract: Indane dimer compounds of general formula 5, 6 or 9 and their pharmaceutical use, particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or antiinflammatory activity are described, wherein in formulae 5 and 9, R1 and R3 to R15, and in formula 6, R1, R2 and R4 to R15, are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oximc, nitro, nitrate, nitrite, nitroso groups, nitrile, heterocyclic groups containing one or more heteroatoms selected from N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 ca
    Type: Application
    Filed: June 8, 1998
    Publication date: May 2, 2002
    Inventors: JOHN WALSH, NEIL FRANKISH, HELEN SHERIDAN, WILLIAM BYRNE
  • Patent number: 6379590
    Abstract: A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D wherein A′ is selected from the group consisting of —Br, —Cl, —F, —NO2, and —CN; A is selected from the group consisting of —NO2, —CN, —CO2R, —C(O)R, —SO2R, —SO2RF, —C(CN)═C(CN)2 and —CH═C(CN)2; RF is —CpF2p+1, p=from about 0 to about 10; R is an straight, branched or cyclic aliphatic alkyl group having about 1 to 10 carbon atoms, or an aromatic group such as phenyl or naphthyl; and is a carbonyl or a protected carbonyl such as a ketal or thio-ketal such as wherein R′ is —CrH2r+1; R″ is —(CH2)r—; and r is independently 2 or 3, with a nucleophilic reagent in the presence of an aprotic solvent
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: April 30, 2002
    Assignee: AlliedSignal Inc.
    Inventors: Chengjiu Wu, Jianhui Shan
  • Patent number: 6376716
    Abstract: A process for the preparation of an aromatic thiophenol represented by the formula (I): Yn—Ar—(SH)m(I), wherein Ar represents an aromatic hydrocarbon; Y represents at least one substituent bonded to a carbon atom constituting the aromatic ring of Ar, which substituent is selected from the group consisting of halogen, nitro, nitrile, sulfone, sulfamoyl and hydrocarbylsulfonyl groups; m is an integer of 1 or more; and n is an integer of 1 or more, which comprises (a) reacting an aromatic thioether represented by the formula (II): Yn—Ar—(SR)m(II), wherein R represents a monovalent secondary or tertiary hydrocarbyl, or a monovalent primary hydrocarbyl group represented by the formula: —CH2—R1 or —CH2—CR2═C (R2)2, wherein R1 represents a monovalent aromatic ring group optionally substituted by a monovalent hydrocarbyl group, and each of R2 is the same or different from each other and represents hydrogen or a monovalent hydrocarbyl group, with (A) a Lewis acid in
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: April 23, 2002
    Assignee: Nippon Finechemical Co., Ltd.
    Inventors: Isamu Arai, Tutomu Yamaguchi, Yoko Hida
  • Patent number: 6281391
    Abstract: This invention encompasses a novel process for synthesizing compounds represented by formula A: These compounds are intermediates useful in the preparation of certain agents that are selective COX-2 inhibitors.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: August 28, 2001
    Assignees: Merck & Co., Inc., Merck Frosst Canada & Co.
    Inventors: Richard D. Tillyer, Ian W. Davies, Robert D. Larsen, Xin Wang, Paul O'Shea, Anthony On-Ping King, Dalian Zhao, Cheng Y. Chen, Edward J. J. Grabowski
  • Patent number: 6218578
    Abstract: The invention relates to a polymeric film composed of an optically anisotropic material made from a cross-linked synthetic resin composition comprising a polymer network, being obtainable by copolymerization of a mixture comprising (a) at least one monomer or oligomer, each of said monomers or oligomers having at least two polymerizable functional groups selected from the group consisting of (meth-)acrylate ester, epoxy and vinyl ether, (b) at least one achiral liquid crystalline monomer or oligomer, each of said monomersloligomers having mesogenic groups and one polymerizable functional group selected from the group consisting of (meth-)acrylate ester, epoxy and vinyl ether.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: April 17, 2001
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: David Coates, Simon Greenfield, Emma Jane Jolliffe
  • Patent number: 6024937
    Abstract: The present invention provides aromatic amine substituted metal chelating compounds, chelates and chelate-targeting moiety conjugates formed from the chelating compounds, and methods for making and using these compounds. Metals capable of being chelated by the chelating compounds include radionuclides, such as .sup.99m Tc and .sup.186188 Re.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 15, 2000
    Assignee: NeoRx Corporation
    Inventors: Sudhakar Kasina, Eric Yau, John M. Reno
  • Patent number: 5936128
    Abstract: The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized 5,6-dihydropyrones and of related structures.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: August 10, 1999
    Assignee: Warner-Lambert Company
    Inventors: Edmund Lee Ellsworth, Elizabeth Lunney, Bradley Dean Tait
  • Patent number: 5932586
    Abstract: This invention relates to ortho substituted phenyl compounds as inhibitors of prostaglandin synthase, to pharmaceutical compositions comprising such compounds and to methods of using such compounds as antiinflammatory and antipyretic agents.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: August 3, 1999
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Douglas Guy Batt, Donald Joseph Phillip Pinto, Michael James Orwat, Joseph James Petraitis, William John Pitts
  • Patent number: 5919985
    Abstract: An object is to provide a method for the production of a sulfide group-containing thiol compound which comprises using a solvent capable of effecting the ring-opening addition reaction of an alkylene sulfide to a thiol compound without inducing the alkylene sulfide to polymerize. A method for the production of a sulfide group-containing thiol compound, which comprises effecting the ring-opening addition reaction of an alkylene sulfide represented by the general formula (1): ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4, which may be identical or different, stand for a hydrogen atom, an alkyl group of 1 to 10 carbon atoms, or an aromatic group of 6 to 15 carbon atoms) to a thiol compound in a solvent of an amide compound or urea substituent-containing compound.
    Type: Grant
    Filed: December 9, 1997
    Date of Patent: July 6, 1999
    Assignees: Nippon Shokubai Co., Ltd., Elf Atochem SA
    Inventors: Hirokazu Itoh, Kazuaki Abe, Takashi Tomita
  • Patent number: 5808164
    Abstract: A process which can be used to produce an aromatic sulfide compound having the formula of (R.sub.4-n)(X.sub.n)(W)Ar--S--R' is provided. The process comprises contacting, in the presence of a surfactant, a halo-substituted aromatic compound in an aqueous solution with a salt of a mercaptan under conditions sufficient to produce the aromatic sulfide in which the halo-substituted aromatic compound and salt of mercaptan are each present in an amount effective to synthesize the aromatic sulfide wherein R is hydrogen or a hydrocarbyl radical, X is a halogen, n is a number from 0 to 3, W is a substituent, Ar is an aromatic ring, and R' is a hydrocarbyl radical.
    Type: Grant
    Filed: January 14, 1997
    Date of Patent: September 15, 1998
    Assignee: Phillipe Petroleum Company
    Inventor: James E. Shaw
  • Patent number: 5750763
    Abstract: The present invention provides:a process for producing an alkali metal salt of an arylmercaptan compound, represented by general formula (3): ##STR1## which process comprises reacting a disulfide compound represented by general formula: ##STR2## with a hydroxide of an alkali metal M.sup.1 in the presence of a sulfur compound represented by general formula (2):H.sub.(2-i) S(M.sup.1).sub.i (2)a process for producing an alkoxycarbonylalkylthioaryl compound represented by general formula (5): ##STR3## which process comprises reacting the above-mentioned alkalimetal salt of an arylmercaptan compound with a halogenofattyacid ester compound represented by general formula (4):X.sup.1 R.sup.2 COOR.sup.3 (4)at pH 7-10; anda process for producing the above-mentioned alkoxycarbonylalkylthioaryl compound, which process comprises reacting the above-mentioned disulfide compound with the above-mentioned hydroxide of an alkali metal M.sup.
    Type: Grant
    Filed: November 8, 1995
    Date of Patent: May 12, 1998
    Assignee: Ihara Chemical Industry Co., Ltd.
    Inventors: Tatsuo Sugiyama, Tadashi Nakayama
  • Patent number: 5712357
    Abstract: A process for the preparation of organic compounds or polymers containing one or more sulphur atoms and including one or more double bonds in a hydrocarbon chain is described. An acyclic sulphur-containing olefin or an unsaturated sulphur-containing cyclic hydrocarbon undergoes a self metathesis reaction or a cross metathesis reaction with a non-sulphur-containing acyclic olefin or a non-sulphur-containing unsaturated cyclic hydrocarbon to produce novel olefins, novel dienes, and/or olefinic polymers containing one or more sulphur atoms.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: January 27, 1998
    Assignee: Elf Aquitaine
    Inventors: Jean-Marie Basset, Jean-Luc Couturier, Michel Leconte, Jean Ollivier, Katsumi Tanaka
  • Patent number: 5600035
    Abstract: Photoreactive compounds are synthesized from 2,5- or 2,6-dintrobenzyl groups. Also disclosed are methods of synthesizing reactive monomers containing 2,5- or 2,6-dintrobenzyl groups.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: February 4, 1997
    Assignee: PPG Industries, Inc.
    Inventors: Charles F. Kahle, II, Neil D. McMurdie, Raphael O. Kollah, Daniel E. Rardon, Gregory J. McCollum
  • Patent number: 5593994
    Abstract: This invention relates to ortho substituted phenyl compounds as inhibitors of prostaglandin synthase, to pharmaceutical compositions comprising such compounds and to methods of using such compounds as antiinflammatory and antipyretic agents.
    Type: Grant
    Filed: September 29, 1994
    Date of Patent: January 14, 1997
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Douglas G. Batt, Donald J. P. Pinto, Michael J. Orwat, Joseph J. Petraitis, William J. Pitts