Benzene Ring Containing Patents (Class 568/67)
  • Patent number: 5426196
    Abstract: The present Invention includes synthetic steps and intermediates involved in the following reaction scheme a of converting compounds of Formula (II) to the diarylmethanes of Formula (I): ##STR1## wherein: Y is oxygen or sulfur;A, B, C, D, and E are carbon or 1, 2 or 3 of A, B, C, D, and E are independently nitrogen, and the others are carbon; andwhereinR.sup.1 through R.sup.10 are selected independently from the group consisting of: hydrogen, hydroxy, alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkyl alkyl, alkenyl, hydroxy alkyl, alkoxy alkyl, perhalo-alkyl, amino, nitro, nitrile, halo, carboxyl, sulfonyl, acyl, formyl, carbamoyl, trifluoromethyl, aminomethyl, azido, amido, hydrazino, aryl, aryloxy, heteroaryl, or aryl or heteroaryl, mono, di, or tri substituted with one or more hydrogen, hydroxy, alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.
    Type: Grant
    Filed: December 22, 1993
    Date of Patent: June 20, 1995
    Assignee: Glaxo Inc.
    Inventor: Francis G. Fang
  • Patent number: 5407960
    Abstract: Mercaptocycloacyl aminoacid inhibitors of endopeptidase of the formula ##STR1## or a pharmaceutically acceptable salt thereof, alone or in combination with an ACE inhibitor or an ANF, in the treatment of cardiovascular disorders such as hypertension, congestive heart failure, edema and renal insufficiency, and treatment of nephrotoxicity pain conditions, and pharmaceutical compositions containing said compounds are disclosed.
    Type: Grant
    Filed: June 11, 1992
    Date of Patent: April 18, 1995
    Assignee: Schering Corporation
    Inventor: Bernard R. Neustadt
  • Patent number: 5354511
    Abstract: Compounds having non-linear optical activity of the general formula ##STR1## wherein D and A are electron donor and acceptor groups, respectively, R.sup.1 and R.sup.2 are aromatic bridging groups, X and Y are preferably groups capable of partaking in polymerization reactions are suitable for use in polymer-based light modulator devices.
    Type: Grant
    Filed: November 27, 1992
    Date of Patent: October 11, 1994
    Assignee: AlliedSignal Inc.
    Inventors: Chengjiu Wu, Jianhui Shan, Ajay Nahata
  • Patent number: 5338886
    Abstract: Disclosed is a process for preparation of an aromatic thiol corresponding to the structureA-(SH)nwhereinA is a substituted or unsubstituted aromatic radical and n is 1, 2, 3, 4, 5 or 6 comprising contacting at a temperature of at least 80.degree. C. an aromatic halide corresponding to the structureA-XmwhereinA is the same as above, X is bromine oriodine and n is 1, 2, 3, 4, 5, or 6with thiourea in the presence of nickel metal.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: August 16, 1994
    Assignee: Eastman Chemical Company
    Inventors: Mark Rule, James T. Tanner, III
  • Patent number: 5266705
    Abstract: A process for production of 2-acetylbenzo[b]thiophene represented by the formula (I): ##STR1## comprising the steps of: (1) reacting 2-halogenobenzaldehyde represented by the formula (II): ##STR2## wherein X represents a halogen atom, with a compound represented by the formula (III):H.sub.i S.sub.j M.sub.kwherein M represents an alkali metal, i represents zero or 1, j represents an integer of at least 1, and k represents an integer of 1 or 2, and preferably also with sulfur; and(2) reacting the reaction product with a monohalogenoacetone represented by the formula (IV) ##STR3## wherein X.sup.1 represents a halogen atom.
    Type: Grant
    Filed: December 29, 1992
    Date of Patent: November 30, 1993
    Assignee: Ihara Chemical Industry Co., Ltd.
    Inventors: Naoto Yazawa, Yoshinori Saito, Hidetaka Hiyoshi
  • Patent number: 5210322
    Abstract: A process for preparing ethers which comprises contacting a carboxylated ether with a metal oxide catalyst under conditions effective to produce the ether.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: May 11, 1993
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventors: Stephen W. King, Kurt D. Olson
  • Patent number: 5171915
    Abstract: It is disclosed that aromatic compounds can be alkylated with mono-olefinic HVI-PAO dimer in contact with an acidic catalyst to produce novel alkylated aromatic compositions. It has been found that the novel HVI-PAO dimer alkylated aromatic compositions exhibit an extraordinary combination of properties relating to low viscosity with high viscosity index and low pour point which renders them very useful as lubricant basestock. Further, it has been found that the novel alkylaromatic compositions of the present invention show improved oxidative stability. Depending upon the substituent groups on the aromatic nucleus, useful lubricant additives can be prepared for improved antiwear, antioxidant and other properties. HVI-PAO dimer is prepared as a product or by-product from 1-alkene oligomerization using reduced chromium oxide on solid support.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: December 15, 1992
    Assignee: Mobil Oil Corporation
    Inventors: Thomas R. Forbus, Bruce P. Pelrine
  • Patent number: 5157164
    Abstract: This invention is addressed to antioxidants which are polymerizable using the Ziegler catalyst system. The antioxidant of the present invention has the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each aryl groups containing a hindered antioxidant structure imparting antioxidant properties to the compounds. The compounds of the present invention are useful in the polymerization of olefin compounds using Ziegler catalyst systems whereby the antioxidant of the invention becomes chemically bound to the polymer while, at the same time, imparting antioxidant properties thereto.
    Type: Grant
    Filed: May 8, 1991
    Date of Patent: October 20, 1992
    Assignee: Copolymer Rubber & Chemical Corp.
    Inventor: Errol J. Olivier
  • Patent number: 5132437
    Abstract: 1-Aminoanthraquinone (1-AAQ) is synthesized by the reaction of 2-chlorobenzyl chloride and xylene in the presence of a solid acid catalyst to yield 2-chloro dimethyldiphenylmethane, subsequent oxidation of the methyl groups, ring closure to form a 1-chloroanthraquinone carboxylic acid, replacement of the 1-chloro group with ammonia, and decarboxylation.
    Type: Grant
    Filed: February 12, 1991
    Date of Patent: July 21, 1992
    Assignee: Hoechst Celanese Corporation
    Inventors: Mohammad Aslam, Daniel A. Aguilar
  • Patent number: 5118858
    Abstract: Disclosed herein are /.sup.35 S/-labelled compound of the formula (I):(C.sub.6 H.sub.5).sub.3 C.sup.35 SHand processes therefor. This Compound (I) is useful as an intermediate for the introduction of sulfur isotope into a variety of compounds. For example, it is useful in the introduction of sulfur isotope into important compounds such as 6-mercaptopurine, 5-[3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl]-8-dimethylcarbamyl-4,6-dith ioactanoic acid, a potent antagonist of leukotriene D.sub.4 ; thiophosphoric acid derivatives, photo-affinity reagents and the like.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: June 2, 1992
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Haydn W. R. Williams, Robert N. Young, Robert J. Zamboni
  • Patent number: 5084214
    Abstract: Phenolic thioethers of the formula: ##STR1## wherein R is a hydrogen atom or a protective group for carboxyl, X is a straight or branched C.sub.4 -C.sub.15 alkylene group, a straight or branched C.sub.1 -C.sub.15 alkylene group having a phenylene group or a straight or branched C.sub.2 -C.sub.15 alkenylene group, and their salts, which inhibit the denaturation of low density lipoproteins (LDL) and the incorporation of LDL by macrophages and are useful as anti-arteriosclerosis agents.
    Type: Grant
    Filed: May 31, 1989
    Date of Patent: January 28, 1992
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toru Kita, Shuh Narumiya, Masayuki Narisada, Fumihiko Watanabe, Saichi Matsumoto, Masami Doteuchi
  • Patent number: 5017727
    Abstract: This invention is addressed to antioxidants which are polymerizable using the Ziegler catalyst system. The antioxidant of the present invention has the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each aryl groups containing a hindered antioxidant structure imparting antioxidant properties to the compounds. The compounds of the present invention are useful in the polymerization of olefin compounds using Ziegler catalyst systems whereby the antioxidant of the invention becomes chemically bound to the polymer while, at the same time, imparting antioxidant properties thereto.
    Type: Grant
    Filed: July 10, 1990
    Date of Patent: May 21, 1991
    Assignee: Copolymer Rubber & Chemical Corporation
    Inventor: Errol J. Olivier
  • Patent number: 5001271
    Abstract: This invention relates to the preparation of benzyl mercaptan by reacting benzyl chloride and ammonium sulfhydrate.In the process according to the invention, the reaction is carried out under autogenous pressure in a closed reactor in two steps. The first comprises adding the benzyl chloride to an aqueous solution of ammonium sulfhydrate at a temperature below 80.degree. C. The second comprises heating the reaction mixture to a temperature in the range 80.degree. to 100.degree. C.
    Type: Grant
    Filed: April 10, 1989
    Date of Patent: March 19, 1991
    Assignee: Societe Nationale Elf Aquitaine (Production)
    Inventor: Yves Labat
  • Patent number: 4996347
    Abstract: The present invention relates, by way of novel industrial products, to osides selected from the group consisting of:(i) the .beta.-.eta.-phenylthioxylosides of the formula: ##STR1## in which: R represents a hydrogen atom, a halogen atom, a nitro group or a cyano group,A represents the sulfur atom or the oxygen atom,B represents a CH.sub.2, CHOH or CO group andY represents the hydrogen atom or an acyl group; and(ii) epimers thereof when B is CHOH.These products are useful in therapy as antithrombotics.
    Type: Grant
    Filed: June 27, 1989
    Date of Patent: February 26, 1991
    Assignee: Fournier Innovation et Synergie
    Inventors: Soth Samreth, Francois Bellamy, Jean Millet
  • Patent number: 4948827
    Abstract: This new thiophenol, prepared by reduction of tertiary butyl-4-toluenesulfonyl-2-chloride with the zinc-sulphuric acid couple, can be used as a stabilizer for vinyl chloride polymers, as a chain-transfer agent and as a peptizer.
    Type: Grant
    Filed: October 25, 1989
    Date of Patent: August 14, 1990
    Assignee: Societe Francaise Hoechst
    Inventor: Yani Christidis
  • Patent number: 4929765
    Abstract: Phenylacetaldehydes of the general formula I ##STR1## where R.sup.1 to R.sup.5 are each independently of the others hydrogen, alkyl, alkoxy, halogen, haloalkyl, haloalkoxy or haloalkylthio, by catalytic rearrangement in the presence of a zeolite, are prepared by reacting an epoxy of the formula II or a phenylglycol of the formula III ##STR2## where Y and Z can be identical to or different from each other and are each hydroxyl, alkoxy, aryloxy or acyloxy, in the gas phase over a borosilicate zeolite catalyst at from 70.degree. to 200.degree. C. under reduced pressure.
    Type: Grant
    Filed: November 22, 1988
    Date of Patent: May 29, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Hubert Smuda, Wolfgang Hoelderich, Norbert Goetz, Hans-Gert Recker
  • Patent number: 4885403
    Abstract: A process for preparing an aromatic propargyl ether, preferably bispropargyl ether, from phenolic compounds comprising vigorously stirring a propargyl halide, preferably propargyl chloride, with a phenolic compound, such as bisphenol A, in an aqueous sodium hydroxide solution at a temperature of from about 0.degree. C. to about 100.degree. C., in the presence of a phase transfer catalyst such as tetrabutylammonium bromide. The mixture is then filtered to recover a solid product. That product is washed with water and propanol. This process provides a product having greater than 98% purity in yields ranging from 85 to 97% of theoretical.
    Type: Grant
    Filed: July 29, 1988
    Date of Patent: December 5, 1989
    Assignee: The Dow Chemical Company
    Inventors: Muthiah N. Inbasekaran, Stoil K. Dirlikov
  • Patent number: 4822918
    Abstract: Organic sulfur compounds, such as sulfonic acids, sulfonyl halides, sulfonates, sulfonamides, sulfonic acid anhydrides, sulfones, sulfoxides and/or disulfanes, are reduced by a method in which the sulfur compound in the liquid or gas phase is reacted with a hydrocarbon in the presence of carbon at from 100.degree. to 500.degree. C.
    Type: Grant
    Filed: September 4, 1987
    Date of Patent: April 18, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Toni Dockner, Manfred Sauerwald
  • Patent number: 4816178
    Abstract: An optically active 4-alkylbenzenethiol and an optically active bis(4-alkylphenyl)disulfide represented by the formula: ##STR1## respectively, wherein R.sub.1 * and R.sub.2 * are respectively an alkyl group having 4-12 carbon atoms including an asymmetric carbon atom, may be prepared, e.g., through halogenation or sulfonation of an optically active alcohol, followed by reaction with a phenylmagnesium halide, chlorosulfonylation and reduction. The optically active thiol or disulfide is effective, e.g., in preventing occurrence of reverse domain when added to a nematic liquid crystal, and also can be bonded to an intermediate to provide a functional material including a mesomorphic compound represented by the formula: ##STR2## wherein R.sub.3 is an alkyl or alkoxy group having 1-18 carbon atoms, n is 1 or 2, and C* is an asymmetric carbon atom.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: March 28, 1989
    Assignee: Canon Kabushiki Kaisha
    Inventors: Kazuharu Katagiri, Kenji Shinjo, Kazuo Yoshinaga
  • Patent number: 4794205
    Abstract: A method is provided for preparing alkenylthiophenols, e.g., para-vinylthiophenol, or their esters, e.g., para-vinylthiophenol acetate by reacting a hydroxy aromatic ketone, e.g., 4-hydroxyacetophenone (4-HAP) with an N,N-di(organo)thiocarbamoyl halide, e.g., N,N-dimethylthiocarbamoyl chloride (DMTC) to form an O-(acylaryl) N,N-di(organo)thiocarbamate, e.g., O-(4'-acetophenyl) N,N-dimethylthiocarbamate, and pyrolytically rearranging the latter compound to form an S-(acylaryl) N,N-di(organo)thiocarbamate, e.g., S-(4-4- -acetophenyl) N,N-dimethylthiocarbamate. In one procedure, the latter compound is directly reduced to form an S-(1-hydroxyalkylaryl) N,N-di(organo) thiocarbamate, e.g., S-[4'-(1-hydroxyethyl)phenyl] N,N-dimethylthiocarbamate, which is either hydrolyzed to form a (1-hydroxyalkyl) thiophenol, e.g., 4'-(1-hydroxyethyl) thiophenol, which optionally after acylation of its thiol group, is dehydrated to form the alkenylthiophenol wherein the double bond is at the ring-bonded carbon atom, e.g.
    Type: Grant
    Filed: December 10, 1986
    Date of Patent: December 27, 1988
    Assignee: Hoechst Celanese Corporation
    Inventors: Mohammad Aslam, Kenneth G. Davenport
  • Patent number: 4754072
    Abstract: Thiophenols are formed from phenols by first reacting a phenol with thiophosgene to form an aryl chlorothionoformate which is subjected to a halogen exchange reaction using an alkali metal fluoride to yield the corresponding fluorothionoformate. This fluorothionoformate is then rearranged to the corresponding fluorothiolformate by heating and the resulting fluorothiolformate is then hydrolyzed to yield the desired thiophenol.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: June 28, 1988
    Assignee: Stauffer Chemical Company
    Inventor: Elliott Bay
  • Patent number: 4700006
    Abstract: Novel carbamoylimidazole derivatives of the formula (I) ##STR1## in which R.sup.1 represents lower alkyl, lower alkoxy-lower alkyl or cycloalkyl having 3 to 8 carbon atoms,R.sup.2 represents fluoro-substituted lower alkyl,X represents oxygen or sulfur,Y represents halogen or lower alkyl,m represents the numbers 0, 1 or 2, andn represents the numbers 2, 3, 4, 5 or 6,and the use of the new compounds as agricultural and horticultural fungicides.
    Type: Grant
    Filed: April 3, 1986
    Date of Patent: October 13, 1987
    Assignee: Nihon Tokushu Noyaku Seizo K.K.
    Inventors: Toyohiko Kume, Yoshio Kurahashi, Kunihiro Isono, Shinji Sakawa, Noboru Matsumoto
  • Patent number: 4652401
    Abstract: Perfume and fragrance compositions containing salicylic acid esters, of which the ester function is derived from secondary or primary branched-chain, saturated aliphatic alcohols containing 6 C-atoms.
    Type: Grant
    Filed: January 8, 1985
    Date of Patent: March 24, 1987
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Ulf-Armin Schaper, Benno Streschnak, Siegfried Bloesl, Walter Sommer
  • Patent number: 4631143
    Abstract: Triphenylene derivatives of the formula I ##STR1## wherein X.sup.1 to X.sup.6 are each, independently of one another, --SH, --SR, --SOR, --SO.sub.2 R or --S--COR, and each R is an alkyl group with up to 20 C atoms, it being possible for one or two CH.sub.2 groups to be replaced by O atoms and/or by unsubstituted or substituted vinylene or vinylidene groups, may be used as components of discotic liquid-crystalline phases.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: December 23, 1986
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Klaus Praefcke, Bernd Kohne, Wadi Poules, Eike Poetsch
  • Patent number: 4621098
    Abstract: The present invention provides thioethers of the general formula: ##STR1## wherein Ar is a phenyl radical which is optionally substituted one, two or three times by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, Q is an oxygen or sulphur atom or an NH group, A is a straight-chained or branched C.sub.2 -C.sub.8 alkylene radical which is optionally substituted by a hydroxyl group or can be interrupted by an ethenylene or ethynylene group, n is 0, 1 or 2, and R is a hydrogen atom or a straight-chained or branched alkyl radical which is optionally substituted one or more times by the same or different radicals selected from alkoxycarbonyl, alkoxy, hydroxyl, carboxyl or optionally substituted carbamoyl or amino; as well as the pharmacologically acceptable salts thereof, with the proviso that A cannot be ethylene when Ar is a phenyl radical, Q is an oxygen atom and R is the group --CH.sub.2 COOH.
    Type: Grant
    Filed: July 2, 1984
    Date of Patent: November 4, 1986
    Assignee: Boehringer Mannheim GmbH
    Inventors: Robert Umminger, Walter-Gunar Friebe, Wolfgang Kampe, Androniki Roesch, Otto-Henning Wilhelms
  • Patent number: 4548761
    Abstract: Process for the preparation of 1-aminobenzene-2-sulphonic acids of the formula ##STR1## wherein R.dbd.H or a substituent andn=1-4,and their salts, in particular their alkali metal salts, by oxidation of compounds of the formula ##STR2## wherein R.sub.1 .dbd.H, a cation, in particular an alkali metal cation, or a radical of the formula ##STR3## characterized in that the oxidation is carried out in a weakly acidic to alkaline pH range. The process can also be carried out as a one-pot process, using the corresponding benzothiazoles as starting materials.
    Type: Grant
    Filed: June 8, 1983
    Date of Patent: October 22, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Martin Michna, Hermann Henk
  • Patent number: 4497960
    Abstract: The invention declares new chiral, optically active compounds of the general formula ##STR1## wherein a 5 or 6 membered lactol ring (E), with X and Y meaning (CR.sup.1 R.sup.2).sub.n, with n=0 to 2 and R.sup.1, R.sup.2 =H, lower alkyl or aryl in any combination which does not impair the anomeric selectivity of I in forming acetals, is fused in a stereospecific manner to a bicyclo[2.2.
    Type: Grant
    Filed: December 6, 1982
    Date of Patent: February 5, 1985
    Inventor: Christian Noe
  • Patent number: 4490532
    Abstract: Hydrogen chloride is passed into p-xylene and acetaldehyde to form bis-1-chloroethyl ether; the latter is converted to 2-(1-chloroethyl)-1,4-dimethylbenzene by the action of sulfuric acid and hydrogen chloride. Alkali metal hydrogen sulfide in aqueous methanol or ethanol converts the 2-(1-chloroethyl)-1,4-dimethylbenzene to alpha,2,5-trimethylbenzenemethanethiol; the sodium salt of the latter reacted with 2-chloropyridine-1-oxide yields 2-[1-(2,5-dimethylphenyl)ethylthio]pyridine-1-oxide which is then oxidized with hydrogen peroxide and alkali metal tungstate or tungstic acid to form 2-[1-(2,5-dimethylphenyl)ethylsulfonyl]pyridine-1-oxide.
    Type: Grant
    Filed: July 28, 1980
    Date of Patent: December 25, 1984
    Assignee: Uniroyal Ltd.
    Inventor: John W. Harris
  • Patent number: 4466914
    Abstract: Disclosed is a mild, efficient, stereo-selective process for a one step conversion of primary and secondary alcohols to their corresponding thiol ester and thiol derivatives with inversion of configuration.
    Type: Grant
    Filed: June 4, 1981
    Date of Patent: August 21, 1984
    Assignee: Merck & Co., Inc.
    Inventors: George G. Hazen, Ralph P. Volante
  • Patent number: 4461918
    Abstract: Disclosed is a process for producing pentachloronitrobenzene (PCNB) by reacting hexachlorobenzene (HEX) with sodium hydrosulfide (NaSH) in the presence of sodium hydroxide (NaOH), sodium carbonate (Na.sub.2 CO.sub.3), or mixtures thereof to produce the sodium salt of pentachlorothiophenol (PCTP), followed by reacting it (or PCTP itself after acidifying) with nitric acid in the presence of sulfuric acid or oleum.
    Type: Grant
    Filed: January 28, 1983
    Date of Patent: July 24, 1984
    Assignee: Uniroyal, Inc.
    Inventors: Walter A. Gay, Robert F. Dietrick
  • Patent number: 4396553
    Abstract: This invention is directed to tetrahydronaphthalene and indane compounds and processes thereto. These compounds are useful as tumor inhibiting agents, in the treatment of neoplasms and dermatological conditions.
    Type: Grant
    Filed: February 4, 1982
    Date of Patent: August 2, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Michael Klaus
  • Patent number: 4347256
    Abstract: This invention relates to substituted isopentenyl phenyl compounds and their use as anti-juvenile hormones. The compounds have been found effective in the control of insects by inhibiting the actions of juvenile hormones. Such compounds act to induce precocious maturation of immature insects resulting in a reduction in the ecological impact of the insect. Additional effects which have been obtained include sterilization of mature insects. Based on previous research it is also believed these compounds will cause interruption of embryogenesis in insect eggs, the induction of diapause in insects and the prevention of sex pheromone secretion in insects.
    Type: Grant
    Filed: March 2, 1981
    Date of Patent: August 31, 1982
    Assignee: Cornell Research Foundation, Inc.
    Inventor: William S. Bowers
  • Patent number: 4343737
    Abstract: A process for producing a thiolcarbamate compound of the following formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a halogen atom or a nitro group, R.sub.2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, m is 1 or 2, and n is an integer of 4 to 6,which comprises reacting an .alpha.-methylstyrene of the following formula ##STR2## wherein R.sub.1 is as defined above, or its dimer with hydrogen sulfide in the presence of a catalyst to form a mercaptan of the following formula ##STR3## wherein R.sub.1 is as defined above, and reacting the mercaptan of formula (II) with a carbamoyl chloride of the following formula ##STR4## wherein R.sub.2, m and n are as defined.
    Type: Grant
    Filed: March 25, 1981
    Date of Patent: August 10, 1982
    Assignee: Mitsubishi Petrochemical Co., Ltd.
    Inventors: Kazuhiko Konno, Atsushi Goh, Kunio Uchimura
  • Patent number: 4331613
    Abstract: A process for the preparation of an optionally substituted trifluoromethyl-naphthalene which comprises contacting a compound of the formula ##STR1## in which R.sup.1 denotes hydrogen, alkyl, aralkyl, aryl, aryloxy, arylthio, polyhalogenoalkoxy, polyhalogenoalkylthio, halogen, nitro, halogenocarbonyl, halogenosulphonyl, alkylsulphonyl or arylsulphonyl, it being possible for the aromatic nuclei contained in the substituents R.sup.1 to be in turn substituted by halogen, alkyl, polyhalogenoalkoxy or polyhalogenoalkylthio,R.sup.2 represents hydrogen, halogen or alkyl andR.sup.3, R.sup.4, R.sup.5 and R.sup.6 denote hydrogen, orR.sup.3 and R.sup.4 or R.sup.4 and R.sup.5 in each case together denote a fused-on aromatic ring, and wherein, in the case where R.sup.3 and R.sup.4 together form a fused-on aromatic ring,R.sup.5 and R.sup.6 independently of one another can also denote, in addition to hydrogen, halogen, nitro, halogenocarbonyl or halogenosulphonyl, and wherein, in the case where R.sup.4 and R.sup.
    Type: Grant
    Filed: June 23, 1980
    Date of Patent: May 25, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Albrecht Marhold, Erich Klauke
  • Patent number: 4328168
    Abstract: This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yield. For the process an alkylating agent and activated methylene compound are reacted in the presence of a cyclic polyether compound and alkali metal compound. Water can also be present and/or the reaction may be carried out in an inert organic diluent.
    Type: Grant
    Filed: October 27, 1980
    Date of Patent: May 4, 1982
    Assignee: Emery Industries, Inc.
    Inventor: Richard G. Fayter, Jr.
  • Patent number: 4328169
    Abstract: This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yield. For the process an alkylating agent and activated methylene compound are reacted in the presence of an alkylene oxide derivative and alkali metal compound. Water can also be present and/or the reaction may be carried out in an inert organic diluent.
    Type: Grant
    Filed: October 27, 1980
    Date of Patent: May 4, 1982
    Assignee: Emery Industries, Inc.
    Inventor: Allen L. Hall
  • Patent number: 4288628
    Abstract: A process for the production of a mono-halothiophenol, e.g. para-chlorothiophenol, and thiophenol. The process comprises reacting a reactant mixture of benzene and dihalobenzene, e.g. para-dichlorobenzene, with hydrogen sulfide in the presence of an absorptive catalyst, such as activated carbon, calcined petroleum coke, etc.
    Type: Grant
    Filed: March 8, 1979
    Date of Patent: September 8, 1981
    Assignee: Stauffer Chemical Company
    Inventor: Kyung S. Shim
  • Patent number: 4284817
    Abstract: Thiophenols are produced by reacting the corresponding benzene compound with hydrogen sulfide in contact with an absorptive catalyst, such as activated carbon, calcined petroleum coke, etc. Temperatures in the range of from about 500.degree. to 900.degree. C. are employed.
    Type: Grant
    Filed: June 2, 1977
    Date of Patent: August 18, 1981
    Assignee: Stauffer Chemical Company
    Inventors: Kyung S. Shim, Adam E. Skrzec
  • Patent number: 4278816
    Abstract: Phenols and thiophenols are produced by reacting the corresponding diphenyl ether compound with hydrogen sulfide in contact with an absorptive catalyst, such as charcoal, activated carbon, calcined petroleum coke, etc. Temperatures in the range of from about 300.degree. to about 900.degree. C. are employed.
    Type: Grant
    Filed: August 26, 1977
    Date of Patent: July 14, 1981
    Assignee: Stauffer Chemical Company
    Inventor: Kyung-sup Shim
  • Patent number: 4252739
    Abstract: This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yields. The process involves reacting an alkylating agent and an activated methylene compound in the presence of an onium compound, an alkali metal compound and water, which while only necessary in trace amounts can be present in substantial quantities.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: February 24, 1981
    Assignee: Emery Industries, Inc.
    Inventors: Richard G. Fayter, Jr., John F. White, Eugene G. Harris
  • Patent number: 4252984
    Abstract: The invention provides phenol ethers of the formula: ##STR1## wherein R is branched C.sub.3-4 alkyl, C.sub.3-4 cycloalkyl, branched cyano(C.sub.3-4 alkyl), phenyl(C.sub.2-3 alkyl), halophenyl(C.sub.2-3 alkyl), (C.sub.1-4 alkoxy)phenyl(C.sub.2-4 alkyl), or (C.sub.1-4 acyl)amino(C.sub.1-4 alkyl),alk is C.sub.1-4 alkyl substituted by a 3 to 6 membered cycloalkyl group,X is --O--, --S-- or --SO.sub.2 --; andR.sub.1 is --C.sub.1-4 alkyl- or --C.sub.1-4 alkoxy-,in their racemic and optically active forms, and their addition salts with pharmaceutically acceptable acids. These compounds are useful in therapy as .beta.-adrenergic blocking agents. Intermediates are also provided.
    Type: Grant
    Filed: October 20, 1976
    Date of Patent: February 24, 1981
    Assignee: Synthelabo
    Inventors: Philippe M. J. Manoury, Icilio A. G. Cavero, Henry Najer, Don Pierre R. L. Giudicelli