Polycyclo Ring System Patents (Class 568/719)
  • Publication number: 20120015992
    Abstract: Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, or NHSO2X, wherein X is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, heterocycle, or substituted heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.
    Type: Application
    Filed: September 21, 2011
    Publication date: January 19, 2012
    Applicant: Burnham Institute for Medical Research
    Inventor: Maurizio Pellecchia
  • Patent number: 8093302
    Abstract: The present invention relates to novel tetralin ER-? agonist compounds, pharmaceutical compositions thereof, and use of these compounds to treat a ER-? mediated disease such as nocturia, obstructive uropathy, benign prostatic hypertrophy, obesity, dementia, hypertension, incontinence, colon cancer, prostate cancer, infertility, depression, leukemia, inflammatory bowel disease, and arthritis.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: January 10, 2012
    Assignee: Eli Lilly and Company
    Inventors: Elizabeth Marie Thomas, Bryan Hurst Norman, Julian Stanley Kroin
  • Patent number: 8063102
    Abstract: The present invention relates to novel tetrahydronaphthalen-2-ol derivatives, to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular to their use for the manufacture of a medicament for the prevention or treatment of lower urinary tract symptoms, benign prostate hyperplasia, prostate cancer, hot flushes, anxiety, depression, breast cancer, medullary thyroid carcinoma, ovarian cancer, inflammatory bowel disease, arthritis, endometriosis, and colon cancer.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: November 22, 2011
    Assignee: N.V. Organon
    Inventors: Herman Thijs Stock, Neeltje Miranda Teerhuis, Gerrit Herman Veeneman
  • Publication number: 20110201845
    Abstract: An object of the present invention is to provide a process for producing high-purity hydroxytriphenylenes in which not only inexpensive raw materials can be used but also no complicated steps of deprotection such as dealkylation, and reduction and the like are necessary, and which is thereby advantageous in industrial production. Also there is provided a novel crystal of 2,3,6,7,10,11-hexahydroxytriphenylene monohydrate, which has satisfactory thermal stability. The process for producing a compound represented by the general formula (2) is characterized by reacting a compound represented by the general formula (1) in the presence of a metal oxide comprising a metal selected from trivalent iron, pentavalent vanadium and hexavalent molybdenum and of a nonvolatile strong acid: wherein, Rs are each independently a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms or an alkoxy group having 1 to 3 carbon atoms.
    Type: Application
    Filed: March 10, 2011
    Publication date: August 18, 2011
    Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.
    Inventors: Daisuke Takano, Tomokazu Kato, Toshihiro Fujinaka, Kazunori Sakamoto
  • Publication number: 20110201739
    Abstract: This disclosure includes a process that unexpectedly can produce very inexpensive graphene and a new compound called graphenol in particulate or dispersions in solvents. The process can also produce graphene layers on metallic and nonmetallic substrates. Further, the graphenol and graphene can be utilized to form nanocomposites that yield property improvements exceeding anything reported previously.
    Type: Application
    Filed: January 11, 2011
    Publication date: August 18, 2011
    Applicant: NATIONAL NANOMATERIALS, INC.
    Inventor: Gary W. Beall
  • Publication number: 20110192464
    Abstract: A polymer, a luminescent material, and the likes are provided, wherein a film can be formed by a wet film-forming method, the film formed has a high stability, and is capable of being laminated with other layers by a wet film-forming method or another method, which are less decrease in charge transportation efficiency or luminescent efficiency, and attain an excellent driving stability. The polymer has a thermally dissociable and soluble group.
    Type: Application
    Filed: August 6, 2009
    Publication date: August 11, 2011
    Applicant: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Toshiyuki Urano, Masayoshi Yabe, Koichiro Iida, Kumiko Takenouchi
  • Publication number: 20110165516
    Abstract: A radiation-sensitive composition containing 1 to 80% by weight of a solid component and 20 to 99% by weight of a solvent. The solid component contains a compound B which has (a) a structure derived from a polyphenol compound A by introducing an acid-dissociating group to at least one phenolic hydroxyl group of the polyphenol compound A which is synthesized by a condensation between a di- to tetrafunctional aromatic ketone or aromatic aldehyde each having 5 to 36 carbon atoms with a compound having 1 to 3 phenolic hydroxyl groups and 6 to 15 carbon atoms, and (b) a molecular weight of 400 to 2000. The composition containing the compound B is useful as an acid-amplified, non-polymeric resist material, because it is highly sensitive to radiation such as KrF excimer lasers, extreme ultraviolet rays, electron beams, and X-rays, and provides resist patterns with a high resolution, high heat resistance, and high etching resistance.
    Type: Application
    Filed: March 18, 2011
    Publication date: July 7, 2011
    Inventors: Masatoshi ECHIGO, Dai Oguro
  • Publication number: 20110151034
    Abstract: To provide an antibacterial agent effective against gram-positive bacteria, particularly an antibacterial agent that is safe even when added to foods and the like, and a disinfecting method. An antibacterial agent comprising as an active ingredient either one or both of compounds represented by the following formula (1) and (2) contained in a labiatae plant extract: This antibacterial agent has antibacterial activity against gram-positive bacteria belonging to the genus Staphylococcus, the genus Lactobacillus, the genus Listeria, the genus Alicyclobacillus or the genus Bacillus.
    Type: Application
    Filed: August 3, 2009
    Publication date: June 23, 2011
    Applicants: Mitsubishi Chemical Corporation, Mitsubishi-Kagaku Foods Corporation
    Inventors: Hirotsugu Kido, Shigeo Ii
  • Patent number: 7964757
    Abstract: An object of the present invention is to provide a process for producing high-purity hydroxytriphenylenes in which not only inexpensive raw materials can be used but also no complicated steps of deprotection such as dealkylation, and reduction and the like are necessary, and which is thereby advantageous in industrial production. Also there is provided a novel crystal of 2,3,6,7,10,11-hexahydroxytriphenylene monohydrate, which has satisfactory thermal stability. The process for producing a compound represented by the general formula (2) is characterized by reacting a compound represented by the general formula (1) in the presence of a metal oxide comprising a metal selected from trivalent iron, pentavalent vanadium and hexavalent molybdenum and of a nonvolatile strong acid: wherein, Rs are each independently a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms or an alkoxy group having 1 to 3 carbon atoms.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: June 21, 2011
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Daisuke Takano, Tomokazu Kato, Toshihiro Fujinaka, Kazunori Sakamoto
  • Publication number: 20110112232
    Abstract: Polyhydroxyfullerenes (PHFs) having enhanced electron scavenging capabilities have a ratio of non-hydroxyl functional groups to hydroxyl functional groups that is less than or equal to 0.3. When combined with a semiconductor photocatalyst, such as titanium dioxide nanoparticles, the PHFs provide a photocatalyst for degradation of chemical and biological contaminates with an efficiency of at least twice that of titanium dioxide nanoparticles free of PHFs. The PRFs are included in these catalysts at a weight ratio to titanium dioxide of about 0.001 to about 0.003, whereas significantly lower and higher ratios do not achieve the highly improved photodegradation capability. PHFs outside of the desired structure are shown to be of little value for photodegradation, and can be inhibiting to the photocatalytic activity of TiO2. The enhanced electron scavenging PHFs can be employed as a component of materials for solar cells, field effect transistors, and radical scavengers.
    Type: Application
    Filed: June 24, 2009
    Publication date: May 12, 2011
    Inventors: Vijay Krishna, Brij M. Moudgil, Benjamin L. Koopman
  • Patent number: 7932014
    Abstract: A photosensitive compound has two or more structural units, in a molecule, represented by the following general formula (1): wherein R1 to R8 are selected from the group consisting of a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an acetoxy group, a phenyl group, a naphthyl group, and an alkyl group in which some or all of the hydrogen atoms are optionally replaced by fluorine atoms; R9 is a hydrogen atom or a hydroxyl group; X is a substituted or unsubstituted phenylene group or a substituted or unsubstituted naphthalene group; and Y is an oxygen atom or a single bond.
    Type: Grant
    Filed: February 14, 2008
    Date of Patent: April 26, 2011
    Assignee: Canon Kabushiki Kaisha
    Inventor: Toshiki Ito
  • Patent number: 7910762
    Abstract: An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or s configuration, and the triol is represented by the following formula: wherein, Y is divalent hydrocarbon and R1 is a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: March 22, 2011
    Assignee: Japan Science and Technology Agency
    Inventors: Shu Kobayashi, Haruro Ishitani, Yasuhiro Yamashita
  • Publication number: 20110015426
    Abstract: A liquid crystalline compound has excellent liquid crystal properties, particularly high phase transition temperature. Diamantane compounds are represented by the general formula (I): (I) wherein A and B are each a six-membered, saturated or unsaturated, carbo- or hetero-cycle, and these cycles may have substituents, which substituents may be united to form a ring; and R1 and R2 are each a hydrocarbon group having 1 to 18 carbon atoms, and part of the carbon atoms of the hydrocarbon group may be replaced by heteroatoms or heteroatom-containing groups, while part of the hydrogen atoms thereof may be replaced by halogen atoms or heteroatom-containing groups.
    Type: Application
    Filed: March 11, 2008
    Publication date: January 20, 2011
    Applicants: NATIONAL UNIVERSITY CORPORATION YOKOHAMA, JX NIPPON OIL & ENERGY CORPORATION
    Inventors: Yasushi Yokoyama, Tsuyoshi Gushiken, Takashi Ubukata
  • Publication number: 20100331398
    Abstract: Gossypol and apogossypol derivatives of general formula (1), preparation thereof and use thereof.
    Type: Application
    Filed: December 5, 2008
    Publication date: December 30, 2010
    Applicant: UNIVERSITE DU MAINE (LE MANS)
    Inventors: Jacques Mortier, Anne-Sophie Castanet, Nguyet Trang Thanh Chau
  • Publication number: 20100331380
    Abstract: Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of ?-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
    Type: Application
    Filed: June 29, 2009
    Publication date: December 30, 2010
    Inventors: Luke A. Esposito, F. Michael Hudson, Thomas Lake, Joel Cummings, Manfred Weigele, Alan Snow, Lesley Larsen
  • Publication number: 20100305320
    Abstract: A polymorph, a polymorph screening system, and a polymorph preparing and screening method are disclosed. The polymorph preparing and screening method includes the following steps: providing a plurality of substrates of different materials; causing an organic material to grow crystals on the plurality of substrates through solution-cooling crystallization process, so that a plurality of polymorphs with different characteristics are prepared; and screening the plurality of polymorphs prepared in the previous step to obtain polymorphs with desired characteristics.
    Type: Application
    Filed: September 29, 2009
    Publication date: December 2, 2010
    Applicant: NATIONAL CENTRAL UNIVERSITY
    Inventors: Tu Lee, Shih-Chia Chang, Jen-Fan Peng, Pu-Yun Wang, Yu-Kun Lin
  • Publication number: 20100249075
    Abstract: The present invention relates to novel tetralin ER-? agonist compounds, pharmaceutical compositions thereof, and use of these compounds to treat a ER-? mediated disease such as nocturia, obstructive uropathy, benign prostatic hypertrophy, obesity, dementia, hypertension, incontinence, colon cancer, prostate cancer, infertility, depression, leukemia, inflammatory bowel disease, and arthritis.
    Type: Application
    Filed: February 10, 2006
    Publication date: September 30, 2010
    Applicant: ELI LILLY AND COMPANY
    Inventors: Venkatesh Krishnan, Julian Stanley Kroin, Bryan Hurst Norman, Elizabeth Marie Thomas
  • Publication number: 20100247462
    Abstract: Processes for synthesizing resveratrol-based oligomers are provided. In addition, resveratrol-based oligomer compounds free of plant extract are provided.
    Type: Application
    Filed: September 17, 2008
    Publication date: September 30, 2010
    Inventors: Scott Alan Snyder, Steven P. Breazzano, Audrey G. Ross, Yunqing Lin, Alexandros L. Zografos
  • Publication number: 20100240748
    Abstract: The present invention relates to novel tetrahydronaphthalen-2-ol derivatives, to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular to their use for the manufacture of a medicament for the prevention or treatment of lower urinary tract symptoms, benign prostate hyperplasia, prostate cancer, hot flushes, anxiety, depression, breast cancer, medullary thyroid carcinoma, ovarian cancer, inflammatory bowel disease, arthritis, endometriosis, and colon cancer.
    Type: Application
    Filed: March 11, 2010
    Publication date: September 23, 2010
    Inventors: Herman Thijs Stock, Neeltje Miranda Teerhuis, Gerrit Herman Veeneman
  • Patent number: 7795459
    Abstract: Paricalcitol, a synthetic vitamin D analog, is purified to a purity greater than 99.7% by crystallization from solution in isopropyl acetate solvent, followed by filtration and vacuum drying. Isopropyl acetate appears to be unique among commonly available and pharmaceutically acceptable solvents in its ability to precipitate paricalcitol in this high purity, essentially free of isomers thereof.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: September 14, 2010
    Assignee: Alphora Research Inc.
    Inventors: Fabio Eduardo Silva e Souza, Ming Pan, Kathleen Da Silva Turcot
  • Publication number: 20100216970
    Abstract: This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation.
    Type: Application
    Filed: May 3, 2010
    Publication date: August 26, 2010
    Inventors: Thomas E. Johnson, Billy T. Fowler
  • Publication number: 20100191020
    Abstract: An object of the present invention is to provide a process for producing high-purity hydroxytriphenylenes in which not only inexpensive raw materials can be used but also no complicated steps of deprotection such as dealkylation, and reduction and the like are necessary, and which is thereby advantageous in industrial production. Also there is provided a novel crystal of 2,3,6,7,10,11-hexahydroxytriphenylene monohydrate, which has satisfactory thermal stability. The process for producing a compound represented by the general formula (2) is characterized by reacting a compound represented by the general formula (1) in the presence of a metal oxide comprising a metal selected from trivalent iron, pentavalent vanadium and hexavalent molybdenum and of a nonvolatile strong acid: wherein, Rs are each independently a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms or an alkoxy group having 1 to 3 carbon atoms.
    Type: Application
    Filed: August 6, 2008
    Publication date: July 29, 2010
    Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.
    Inventors: Daisuke Takano, Tomokazu Kato, Toshihiro Fujinaka, Kazunori Sakamoto
  • Publication number: 20100185022
    Abstract: A method for the preparation of calix[n]arene derivatives, in particular phosphonated calix[n]arenes. The present invention also relates to nano-structures of phosphonated calix[n]arenes.
    Type: Application
    Filed: June 6, 2008
    Publication date: July 22, 2010
    Inventors: Colin L. Raston, Mohamed Makha, Thomas Edward Clark, Jerry L. Atwood
  • Publication number: 20100144821
    Abstract: The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, A? protein or ?-synuclein protein aggregation.
    Type: Application
    Filed: November 19, 2007
    Publication date: June 10, 2010
    Applicant: Queen's University at Kingston
    Inventors: Michael D. Carter, Donald F. Weaver, Sheila Marie H. Jacobo, Erhu Lu, Fuye Gao
  • Patent number: 7705189
    Abstract: A novel calixarene compound, a method for manufacturing the same, an intermediate of the calixarene compound, and a composition comprising the same are provided. The calixarene compound is expected to be useful as an inclusion compound and, if functional groups are introduced, can be used for a curable composition and a photoresist and as an inclusion compound.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: April 27, 2010
    Assignees: JSR Corporation, Kanagawa University
    Inventors: Tadatomi Nishikubo, Hiroto Kudou, Kouji Mitani
  • Publication number: 20100029968
    Abstract: An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or s configuration, and the triol is represented by the following formula: wherein, Y is divalent hydrocarbon and RI is a hydrogen atom, a halogen atom, a trifluoromethyl group, or an alkyl group or alkoxy group having at most 4 carbons.
    Type: Application
    Filed: September 28, 2009
    Publication date: February 4, 2010
    Applicant: Japan Science and Technology Agency
    Inventors: Shu Kobayashi, Haruro Ishitani, Yasuhiro Yamashita
  • Publication number: 20100009284
    Abstract: A compound including a polyhydric phenol compound represented by general formula (I) shown below (wherein R11 to R17 each independently represents an alkyl group of 1 to 10 carbon atoms or aromatic hydrocarbon group which may contain a hetero atom in the structure thereof, and X represents an aliphatic cyclic group) and having a molecular weight of 300 to 2,500, in which some or all of the hydrogen atoms of the phenolic hydroxyl groups are substituted with acid dissociable, dissolution inhibiting groups; a positive resist composition containing the compound; and a method of forming a resist pattern using the positive resist composition.
    Type: Application
    Filed: June 7, 2006
    Publication date: January 14, 2010
    Applicant: TOKYO OHKA KOGYO CO., LTD.
    Inventors: Daiju Shiono, Taku Hirayama, Hideo Hada
  • Publication number: 20090111863
    Abstract: Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of ?-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
    Type: Application
    Filed: October 3, 2008
    Publication date: April 30, 2009
    Inventors: Luke A. Esposito, F. Michael Hudson, Thomas Lake, Joel Cummings, Manfred Weigele, Alan Snow, Lesley Larsen
  • Publication number: 20090105319
    Abstract: Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently selected from the group consisting of H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, and NHSO2X, wherein X is selected from the group consisting of an alkyl, a substituted alkyl, an aryl, a substituted aryl, an alkylaryl, and a heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.
    Type: Application
    Filed: October 17, 2008
    Publication date: April 23, 2009
    Applicant: Burnham Institute for Medical Research
    Inventors: Maurizio Pellecchia, John C. Reed
  • Publication number: 20090103241
    Abstract: An activated carbon comprising a carbonized and activated compound represented by the formula (1): (wherein, R represents a hydrocarbon group having 1 to 12 carbon atoms, said hydrocarbon group may be optionally substituted with hydroxyl group, alkyl group, alkoxy group, aryl group, aryloxy group, sulfonyl group, halogen atoms, nitro group, thioalkyl group, cyano group, carboxyl group, amino group or amide group, R? represents hydrogen atom or methyl group, and n represents an integer of 4, 6, or 8).
    Type: Application
    Filed: May 24, 2006
    Publication date: April 23, 2009
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Taketoshi Kikuchi, Tamon Itahashi
  • Publication number: 20090099250
    Abstract: The present invention describes non-steroidal compounds of the general formula (I) in which A is in which X1 means one or more groups on the phenyl ring and represents independently of one another a halogen, OH, (C1-C4)alkyl, (C1-C4)alkyl-O, (C3-C6)cycloalkyl-O, (C1-C14)acyl-O, (C1-C4)alkenyl, (C1-C4)alkynyl, perfluoro(C1-C4)alkyl radical, —CHO or CN, and X2 means one or more groups on the phenyl ring and represents independently of one another an H, halogen, OH, (C1-C4)alkyl, (C1-C4)alkyl-O, (C1-C4)alkenyl, (C1-C4)alkynyl, perfluoro-(C1-C4)alkyl radical, —CHO or CN, as Estrogens.
    Type: Application
    Filed: October 10, 2008
    Publication date: April 16, 2009
    Inventors: Ralf WYRWA, Olaf Peters, Rolf Bohlmann, Peter Droescher, Katja Prelle, Karl Heinrich Fritzemeier, Hans Peter Muhn
  • Publication number: 20090042980
    Abstract: Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keap1, a negative regulator of the transcription factor Nrf2, and prevent Keap1-mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keap1/Nrf2 complex.
    Type: Application
    Filed: October 10, 2007
    Publication date: February 12, 2009
    Applicant: Burnham Institute for Medical Research
    Inventors: Stuart A. Lipton, Takumi Satoh
  • Publication number: 20090012061
    Abstract: The present invention relates to a method of treating cellular proliferative diseases, in particular cancer, which comprises administering a modulator of the activity of the mitotic kinesin KSP, wherein the activity of the KSP modulator is dependent on the presence of microtubules. It is believed that the KSP modulators utilized in the instant method bind to the KSP protein in a previously unreported manner, since the compounds do not bind competitively with respect to either microtubules or ATP, the substrates of KSP. The modulators useful in the instant methods are furthermore not active against the non-microtubule stimulated activity of KSP. Cellular proliferative diseases that may be treated using the method disclosed herein are, for example cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation.
    Type: Application
    Filed: September 9, 2005
    Publication date: January 8, 2009
    Inventors: Timothy A. Blizzard, Carolyn A. Buser-Doepner, Douglas E. Frantz, Kelly Hamilton, Myle Hoang, Ling Lee, Christopher R. Moyes, Jerry A. Murry, Arash Soheili
  • Publication number: 20080242896
    Abstract: A new 1,3-bis(3-formyl-4-hydroxyphenyl)adamantane, which provides a material offering excellent properties such as heat resistance and mechanical strength for use as an intermediate material for adamantanebisphenol derivatives or use in photosensitive resist materials, epoxy resins and other synthetic resins, thermosensitive recording materials, and the like, can be obtained through an industrial process in an easy manner at a good yield and high purity by producing a Schiff base from a 1,3-bis(4-hydroxyphenyl)adamantane by causing it to react with a hexamethylenetetramine or other substance in the presence of an acid, and then hydrolyzing the obtained Schiff base using an acid. A new polynuclear polyphenol is also provided that may be derived from the same.
    Type: Application
    Filed: June 13, 2006
    Publication date: October 2, 2008
    Applicant: Honshu Chemical Industry Co., Ltd.
    Inventors: Akira Yoshitomo, Tatsuya Iwai, Kentaro Watanabe
  • Publication number: 20080176956
    Abstract: Modified green tea polyphenols and methods of their use are provided. One aspect provides compounds and compositions containing green tea polyphenols with one on more ester-linked fatty acids.
    Type: Application
    Filed: August 10, 2006
    Publication date: July 24, 2008
    Inventor: Stephen D. Hsu
  • Patent number: 7217846
    Abstract: A guest host assembly comprising a host assembly formed of calixarene molecules and a guest component located within the host assembly. A crystallographic assembly of layers of the calixarene molecules and stacked along the crystallographic c axis of the assembly in a repeating configuration associated together predominantly by van der Waal forces. The guest component is transferable through the host assembly in a direction normal to the stacked layers. The calixarene molecules are configured in bilayers of adjacent layers along the c axis. The bilayers are shifted along the a or b axis so the assembly, relative to a corresponding assembly of the calixarene molecules without the inclusion of the guest component is shifted. The calixarene are calix(N)arenes in which N is an integer within the range of 4–8. The calixarene molecules are distally substituted with a substituent such as methyl, ethyl, propyl, butyl amyl or phenyl groups.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: May 15, 2007
    Inventors: Jerry L. Atwood, Leonard J. Barbour, Agoston Jerga
  • Patent number: 7214834
    Abstract: The present invention relates to a method for the chemical separation of the enantiomers of 1,1?-spirobiindane-6,6?-diol derivatives comprising providing a racemic chiral 1,1?-spirobiindane-6,6?-diol derivative, reacting a nonracemic chiral component with the racemic chiral 1,1?-spirobiindane-6,6?-diol derivative to afford a mixture of diastereomeric diesters, separating the mixture of diastereomeric diesters to provide a substantially pure individual diastereomeric diester, and chemically removing the ester groups from the substantially pure individual diastereomeric diester to provide a nonracemic chiral 1,1?-spirobiindane-6,6?-diol derivative.
    Type: Grant
    Filed: July 20, 2004
    Date of Patent: May 8, 2007
    Assignee: Eastman Kodak Company
    Inventor: Thomas R. Welter
  • Patent number: 7196232
    Abstract: Produce new 4,4?-dihydroxyphenyl bicyclohexenes that are useful as a material for liquid crystal polyester, polycarbonate, polyurethane or other synthetic resins or for photoresist used with display elements, semiconductors, etc., by thermally decomposing 4,4,4?4?-tetrahydroxyphenyl bicyclohexanes, preferably in the presence of alkali catalyst.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: March 27, 2007
    Assignee: Honshu Chemical Industry Co., Ltd.
    Inventors: Kouji Satomi, Hiroyasu Oono, Kenji Ekawa
  • Patent number: 7169957
    Abstract: Disclosed are the general principles upon which closed molecular or ionic structural frameworks may be prepared. These frameworks are based upon the self-assembly (wherein the term self-assembly refers to the association of chemical components through inter-component bonds) of n>4 subunits where surface curvature is supplied by edge sharing of subunits.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: January 30, 2007
    Inventors: Jerry L. Atwood, Leonard R. MacGillivray
  • Patent number: 7071365
    Abstract: The compositions 3-alkylated-5,5?,6,6?,7,7?,8,8?-octahydro-2,2?-binaphthol and 3,3?-dialkylated-5,5?,6,6?,7,7?,8,8?-octahydro-2,2?-binaphthol are disclosed, as well as various processes for making them, all involving the alkylation of 5,5?,6,6?,7,7?,8,8?-octahydro-2,2?-binaphthol.
    Type: Grant
    Filed: April 11, 2005
    Date of Patent: July 4, 2006
    Assignee: Invista North America S.A.R.L.
    Inventors: Helen S. M. Lu, Weiming Qiu, Rafael Shapiro
  • Patent number: 7014868
    Abstract: A composition comprising a guest/host assembly having a spheroidal host assembly comprised of a hexamer of a methylene-bridged trihydroxybenzene tetramer and a guest component encapsulated within the spheroidal host assembly to provide a highly stable guest/host assembly. A guest component, specifically a pharmaceutically active agent, is encapsulated within the spheroidal host assembly to provide a guest/host assembly exhibiting a high stability, being stable upon a solubilization in a mixture of acetone and water in a one-to-one ratio for a period of one day at a temperature of 37° C. The pharmaceutically active agent encapsulated within the spheroidal hexamer is selected from the group consisting of Depakote, Wellbutrin, Allegra, Neurontin, Zovirax, and Claritin. A process for the preparation of a hexameric complex, as described above, from a methylene-bridged tetramer solubilized in an amphiphilic organic solvent. An activator is incorporated into the amphiphilic solvent containing the tetramer.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: March 21, 2006
    Assignee: Curators of the University of Missouri
    Inventor: Jerry L. Atwood
  • Patent number: 6921842
    Abstract: The hydrogenated aromatic oligomer of this invention is represented by the following formula (1) (A-F)n-A??(1) (wherein A is a segment comprising mainly a polycyclic aromatic compound, a phenol and at least partly hydrogenated products of these two, F is methylene or dimethylene ether and n is a number in the range of 1-100) and obtained by the reaction of a polycyclic aromatic compound such as naphthalene with formaldehyde or a derivative thereof and a phenol in the presence of an acid catalyst followed by hydrogenation of the product aromatic oligomer. This oligomer is odorless, highly transparent and useful as an improver of the adhesiveness and vibration damping properties when incorporated in resins and rubbers and performs excellently as a vibration damping agent in a wide temperature range.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: July 26, 2005
    Assignee: Nippon Steel Chemical Co., Ltd.
    Inventors: Toshihide Senzaki, Takahiro Imamura, Takehiro Shimizu, Munehito Nagai
  • Patent number: 6914074
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: July 5, 2005
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Eric S. Manas
  • Patent number: 6891072
    Abstract: The present invention provides a method for preparing dimer of a monohydroxy aromatic compound. In the method of the present invention, oxidative coupling reaction of a monohydroxy aromatic compound represented by formula [I]: Ar—OH??[I] wherein Ar represents an optionally substituted aromatic group is carried out in a nitrogen containing polar solvent in the presence of a copper salt. By the method of the instant invention, dimer of the monohydroxy aromatic compound can be obtained in high yield.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: May 10, 2005
    Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo
    Inventors: Ryuzo Ueno, Masaya Kitayama, Kenji Minami, Hiroyuki Wakamori, Hikari Hirai
  • Patent number: 6838584
    Abstract: The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: January 4, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Timothy Allen Blizzard, Milton Lloyd Hammond, Jerry Dwain Morgan, Ralph Troy Mosley
  • Patent number: 6838583
    Abstract: An antimicrobial compound, composition containing such compound, and method of use of the same for reducing the presence of microorganism on a substrate or in a fluid environment comprising an antimicrobial effective carrier and one or more essential antimicrobial compounds including non-halogenated naphthol compounds.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: January 4, 2005
    Assignee: Warner-Lambert Company LLC
    Inventors: David Scott Harper, Robert A. Coburn, Andre Soshinsky, Constantine Georgiades, Marianne D. Huntley
  • Patent number: 6803489
    Abstract: A process is provided for the purification of 4,4′-(9-fluorenylidene)diallylphenol. With an inclusion-compound-forming solvent which contains an inclusion-compound-forming compound capable of forming an inclusion compound with 4,4′-(9-fluorenylidene)diallylphenol, crude 4,4′-(9-fluorenylidene)diallylphenol is dissolved to form the inclusion compound in the form of a solution. The inclusion compound is then caused to deposit, for example, by charging the solution of the inclusion compound into a poor solvent for the inclusion compound, for example, an aliphatic hydrocarbon solvent such as n-hexane, n-heptane, cyclohexane or a mixture thereof.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: October 12, 2004
    Assignee: JFE Chemical Corporation
    Inventors: Hiroaki Mori, Shigeki Inatomi
  • Patent number: 6756375
    Abstract: The invention provides for a non-steroidal compound having the formula wherein Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2— or —CH2CH2—; R1 is H, halogen, CF3, or (1C-4C)alkyl; R2, R3 and R4 are independently H, halogen, —CF3, —OCF3, (1C-8C)Alkyl, hydroxy, (1C-8C)alkyloxy, aryloxy, aryl(1C-8C)alkyl, halo(1C-8C)alkyl, —O(CH2)mX, wherein X is halogen or phenyl and m=2-4; —O(CH2)mNRaRb, —S(CH2)mNRaRb or —(CH2)mNRaRb, wherein m=2-4 and Ra, Rb are independently (1C-8C)alkyl, (2C-8C)alkenyl, (2C-8C)alkynyl, or aryl, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, —OH, (1C-8C)alkoxy, aryloxy, carboxyl, (1C-8C)alkylthio, carboxylate, (1C-8C)alkyl, aryl, aryl(1C-8C)alkyl, halo(1C-8C)alkyl or Ra and Rb form a 3-8 membered ring structure, optionally substituted with halogen, —CF3, —OCF3, —CN, —NO2, hydroxy, hydroxy(1C-4C)a
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: June 29, 2004
    Assignee: Akzo Nobel N.V.
    Inventors: Gerrit Herman Veeneman, Hubert JanJozef Loozen, Jordi Mestres, Eduard Willem De Zwart
  • Patent number: 6723801
    Abstract: An object of the present invention is to provide an epoxy resin composition which has high flexibility, can be molded to a thin membrane, and can become a noninflammable cured product. The present invention comprises a polyphenol compound obtained by reacting to condense phenol with bischloromethyl biphenyl or bismethoxymethyl biphenyl, removing unreacted phenol and then reacting with BCMB again, wherein the polyphenol compound has a weight-average molecular weight of 3,000 or more as determined by GPC, and using the polyphenol compound as an agent for curing an epoxy resin.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: April 20, 2004
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Yasumasa Akatsuka, Toyofumi Asano, Masahiro Imaizumi, Katsuhiko Oshimi, Syouichi Tomida
  • Patent number: 6720460
    Abstract: Hydroxyphenyl adamantanes are represented by the general formula (1): wherein R is an alkyl group, cycloalkyl group or phenyl group; m is 0 or an integer 1 or 2; l is 0 or 1; when l is 1, hydroxy groups of substituted hydroxyphenyl groups at positions 1 and 3 are together in para-position; n is 0 or an integer 1, 2 or 3; and when l is 0, n is an integer 1, 2 or 3.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: April 13, 2004
    Assignee: Honshu Chemical Industry Co., Ltd.
    Inventors: Akira Yoshikawa, Kenji Ekawa, Kentaro Watanabe, Kazuhiko Yao, Miwa Hazama