Abstract: Compounds of di-(3'-hydroxyphenyl)-alkanes and their methyl ethers, of the formula ##STR1## wherein R is alkyl and R' is H or methyl, have activity against hormone-dependent breast carcinoma.
Type:
Grant
Filed:
May 3, 1977
Date of Patent:
June 13, 1978
Assignee:
Klinge Pharma GmbH
Inventors:
Helmut Schonenberger, Gerhard Kranzfelder, Helga Schmitt-Wallenborn
Abstract: Iodine is employed as a promoter for the reaction between phenol and a 1,2-dihaloethane wherein the halogen is chlorine, bromine or iodine using a zinc-containing catalyst to produce dihydroxydiphenylethanes, especially the 4,4'-isomer.
Abstract: Hydrogenolysis of hydrobenzoins [1,2-bis(aryl)ethane-1,2-diols] in the presence of a catalyst comprising cobalt carbonyl yields 1,2-bis(aryl)ethanes. The process is particularly directed to the production of 1,2-bis(4-hydroxyphenyl)ethane from 4,4-dihydroxyhydrobenzoin [1,2-bis(4-hydroxyphenyl)ethane-1,2-diol].