Hydroxy Bonded Directly To The Ring (e.g., Terpin Hydrate, Etc.) (h Of -oh May Be Replaced By A Group Ia Or Iia Light Metal) Patents (Class 568/832)
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Publication number: 20150080614Abstract: The present invention provides a process and catalyst for the conversion of phenol and its derivatives to cyclohexane and cyclohexanol. The process provides a direct single step for selective hydrogenation of phenol and its derivatives over Pt—Ce oxide catalyst. The process provides a phenol conversion of 50 to 100% and selectivity of hydrogenated product up to 98%.Type: ApplicationFiled: September 18, 2014Publication date: March 19, 2015Inventors: Bal RAJARAM, Sarkar Bipul, Singha Rajib Kumar, Pendem Chandrashekar, Shankha Shubhra Acharyya, Ghosh Shilpi, Goyal Reena, Das Subhasis, Bordoloi Ankur, Konathala Laxmi Narayan Sivakumar
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Publication number: 20150025266Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: ApplicationFiled: July 16, 2013Publication date: January 22, 2015Applicant: Pioneer Energy, Inc.Inventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
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Publication number: 20130338403Abstract: Provided is an alicyclic alcohol compound which can be used as a raw material for a compound perfume, and which has excellent floral-green-like aromas which are crisp and fresh; also provided are a manufacturing method for the same, and a perfume composition which contains the alicyclic alcohol compound. An alicyclic alcohol compound having a specified structure represented by chemical formula (1) has excellent floral-green-like aromas which are crisp and fresh; and a method for manufacturing the alicyclic alcohol compound represented by chemical formula (1) by reacting, in the presence of hydrogen fluoride, 1-isopropyl-4-methylcyclohexene and carbon monoxide, reacting the resulting 4-isopropyl-1-methylcyclohexane carboxylic acid fluoride with alcohol, and, after having acquired a cyclohexane carbonyl compound, reducing the cyclohexane carbonyl compound.Type: ApplicationFiled: December 27, 2011Publication date: December 19, 2013Applicant: Mitsubishi Gas Chemical Company, INC.Inventors: Mitsuharu Kitamura, Yoshiharu Ataka, Kazuyuki Fukuda
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Publication number: 20130197245Abstract: An organometallic molybdenum acetylide dioxo complex of formula (?5-C5H5)MoO2(—Cs?CPh) and provides a simple, short, efficient process for the synthesis of organometallic molybdenum dioxo complex which is used as catalyst for a number of oxidation reactions.Type: ApplicationFiled: March 14, 2013Publication date: August 1, 2013Inventors: Shubhangi Bhalchandra Umbarkar, Mohan Keraba Dongare, Ankush Biradar, Vaibhav Ravindrakumar Acham
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Publication number: 20130118063Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.Type: ApplicationFiled: November 8, 2012Publication date: May 16, 2013Applicant: Pioneer EnergyInventors: John Henri, Jan Zygmunt, Mark Bergren, Robert Zubrin
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Patent number: 8269051Abstract: The present invention includes wickerol and a method for producing the wickerol. In the method for producing the wickerol, Trichoderma atroviride strain FKI-3737 (FERM ABP-11099 corresponding to FERM BP-11099) belonging to filamentous fungi is cultured in a medium, and the wickerol is accumulated in a culture, and then the produced wickerol is isolated and purified from the culture. A substance having inhibitory activity against influenza virus replication and containing the wickerol as an active ingredient, and an anti-influenza drug containing the wickerol as an active ingredient are obtained.Type: GrantFiled: March 12, 2009Date of Patent: September 18, 2012Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Rokuro Masuma, Hideaki Ui, Takayuki Nagai, Haruki Yamada
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Patent number: 8232430Abstract: The present disclosure relates to a method for the stereoselective production of cis-4-tertbutylcyclohexanol comprising contacting 4-tert-butylcyclohexanone with hydrogen gas, a catalyst comprising a ruthenium-aminophosphine complex and a base, wherein the complex is of the formula RuX2(PNH2)a(P2)b (I), wherein X is anionic ligand, (PNH2) represents an aminophosphine ligand of the formula (II) R1R2P-L-NH2 and (P2) represents a diphosphine ligand of the formula (III) R3R4P-L-PR5R6.Type: GrantFiled: July 7, 2008Date of Patent: July 31, 2012Assignee: Kanata Chemical Technologies Inc.Inventors: Kamaluddin Abdur-Rashid, Xuanhua Chen, Rongwei Guo, Wenli Jia
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Publication number: 20120172632Abstract: The invention relates to a continuous method for the catalytic hydrogenation of an aromatic compound into a cycloaliphatic compound, wherein said method is carried out in a piston reactor provided with a mechanical axially agitating means and comprises continuously feeding a liquid phase comprising said aromatic compound and a catalyst dispersed to the liquid phase, subjecting said liquid phase, at a temperature of between 100° C. and 300° C. and while being mechanical axially agitated, to the effects of a hydrogen pressure of between 10 and 250 bars in the presence of said catalyst dispersed in the liquid phase for a residence time of between 1 second and 10 minutes, and removing the liquid phase from the reactor.Type: ApplicationFiled: June 10, 2010Publication date: July 5, 2012Applicant: AET GroupInventors: Sabrina Marie, Alexandre Trani, Raimondo Pilia
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Publication number: 20120123166Abstract: Method of preparing 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane comprising step (ii): (ii) converting 3,3,5,5-tetramethylcyclohexanone to 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane by using methylmagnesium chloride. 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane may be used for preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 28, 2010Publication date: May 17, 2012Applicant: MERZ PHARMA GmbH & CO. KGaAInventors: Herbert Koller, Michael Pyerin, Federico Sbrogio
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Publication number: 20100204524Abstract: The present disclosure relates to a method for the stereoselective production of cis-4-tertbutylcyclohexanol comprising contacting 4-tert-butylcyclohexanone with hydrogen gas, a catalyst comprising a ruthenium-aminophosphine complex and a base, wherein the complex is of the formula RuX2(PNH2)a(P2)b (I), wherein X is anionic ligand, (PNH2) represents an aminophosphine ligand of the formula (II) R1R2P-L-NH2 and (P2) represents a diphosphine ligand of the formula (III) R3R4P-L-PR5R6.Type: ApplicationFiled: July 7, 2008Publication date: August 12, 2010Inventors: Kamaluddin Abdur-Rashid, Xuanhua Chen, Rongwei Guo, Wenli Jia
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Publication number: 20100168440Abstract: Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.Type: ApplicationFiled: February 9, 2010Publication date: July 1, 2010Applicant: Takasago International CorporationInventors: Hideo SHIMIZU, Daisuke Igarashi, Wataru Kuriyama, Yukinori Yusa
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Patent number: 7671242Abstract: An efficient method is disclosed for extracting lutein from corn, sweet potato, and other plant products, and for extracting aflatoxin-free lutein from aflatoxin-contaminated plant grains and other plant products safely without any toxic by-products. The lutein is extracted using acetone, and either chilled or saponified to separate from the lipids. If contaminated with aflatoxin, the extracted aflatoxin-contaminated lutein is treated with lipoxidase. This method may be used in producing aflatoxin-free lutein from other contaminated grains or plant oils, or other plant products, including corn, cotton, soybean, rice, barley, wheat, maize, millet, and peanut.Type: GrantFiled: December 21, 2005Date of Patent: March 2, 2010Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Jack N. Losso, Evdokia Menelaou, Joan M. King
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Publication number: 20090326235Abstract: The present invention relates to anhydrous solutions of MX3-Z LiA in a solvent, wherein M is a lanthanide including lanthanum, or yttrium or indium; z>0; and X and A are independently or both monovalent anions, preferably Cl, Br or I. The solution is readily prepared by dissolving or suspending MX3 or its hydrate and z equiv LiA in water or hydrophilic solvents, or mixtures thereof, removing the solvent under vacuum and dissolving the resulting powder in another solvent. The solution of MX3-Z LiA can advantageously be used e.g. in addition reactions of Grignard reagents to ketones and imines. Even the catalytic use of MX3-Z LiA is possible.Type: ApplicationFiled: September 1, 2006Publication date: December 31, 2009Inventors: Paul Knochel, Arkady Krasovskiy, Felix Kopp
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Publication number: 20090170818Abstract: This invention discloses (20S)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs, and specifically (20S)-23,23-difluoro-1?-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.Type: ApplicationFiled: December 24, 2008Publication date: July 2, 2009Inventors: Hector F. DeLuca, Lori A. Plum, Rafal Barycki, Margaret Clagett-Dame
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Publication number: 20090170819Abstract: This invention discloses (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs, and specifically (20R)-23,23-difluoro-1 ?-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.Type: ApplicationFiled: December 24, 2008Publication date: July 2, 2009Inventors: Hector F. DeLuca, Lori A. Plum, Rafal Barycki, Margaret Clagett-Dame
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Publication number: 20090105481Abstract: Process for stereoselective hydrogenation by reacting racemic aldehydes or ketones having a stereogenic carbon atom in the position relative to the C(O) group and containing the structural element —(O)C—C—CH— by means of hydrogen in the presence of a base and a ruthenium complex containing a bidentate ligand having coordinating P and N atoms, a monophosphine ligand and anionic and/or uncharged ligands as homogeneous catalyst, with the charge being balanced by one or two monovalent acid anions or a divalent acid anion when uncharged ligands are present.Type: ApplicationFiled: March 8, 2007Publication date: April 23, 2009Inventors: Felix Spindler, Ulrike Nettekoven, Mauro Perseghini
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Patent number: 7442841Abstract: A process for the separation of an alcohol from a non-polar solvent; a ketone from a non-polar solvent; an alcohol from a mixture of a ketone and a non-polar solvent; or a mixture of an alcohol and a ketone from a non-polar solvent; said process comprising contacting at least one ionic liquid with a mixture comprising a non-polar solvent and at least one of an alcohol and a ketone.Type: GrantFiled: August 16, 2007Date of Patent: October 28, 2008Assignee: Invista North America S.A R.L.Inventor: Keith Whiston
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Patent number: 7378542Abstract: The invention provides alkene fluoroalkanol and fluorinated polyol precursors to fluoroalkanol-substituted ?,?-unsaturated esters. The fluoroalkanol-substituted ?,?-unsaturated esters are olefins that can be readily polymerized to provide fluoroalkanol-substituted polymers useful in lithographic photoresist compositions. Also provided are methods for synthesizing the alkene fluoroalkanol and fluorinated polyol precursors.Type: GrantFiled: August 24, 2007Date of Patent: May 27, 2008Assignee: International Business Machines CorporationInventors: Gregory Breyta, Richard Anthony DiPietro, Daniel Joseph Dawson
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Patent number: 7365235Abstract: Processes for producing branched compounds are described wherein a carbonyl compound is condensed in the presence of a catalyst selected from the group consisting of acids and bases, to form an ?,?-unsaturated condensation product; and the ?,?-unsaturated condensation product is hydrogenated.Type: GrantFiled: September 11, 2001Date of Patent: April 29, 2008Assignee: Cognis Deutschland GmbH & Co. KGInventors: Sabine Both, Albrecht Schwerin, Erich Reuter, Georg Fieg, Juergen Falkowski
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Publication number: 20080051609Abstract: A process for the separation of an alcohol from a non-polar solvent; a ketone from a non-polar solvent; an alcohol from a mixture of a ketone and a non-polar solvent; or a mixture of an alcohol and a ketone from a non-polar solvent; said process comprising contacting at least one ionic liquid with a mixture comprising a non-polar solvent and at least one of an alcohol and a ketone.Type: ApplicationFiled: August 16, 2007Publication date: February 28, 2008Applicant: INVISTA NORTH AMERICA S.A.R.L.Inventor: KEITH WHISTON
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Patent number: 6849767Abstract: A method of hydroborating an alkene or alkyne, or reducing an organic functionality, oxidizing primary and secondary alcohols using a fluorous borane-sulfide is disclosed. The method includes regeneration and recycling the fluorous borane-sulfide.Type: GrantFiled: July 24, 2003Date of Patent: February 1, 2005Assignee: The Board of Trustees of the University of IllinoisInventors: David C. Crich, Santhosh Neelamkavil
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Patent number: 6774269Abstract: A process for producing l-isopulegol by simple operations with safety in high yield. A process for producing isopulegol, which comprises selectively cyclizing citronellal in the presence of a tris(2,6-diarylphenoxy)aluminum catalyst represented by the following general formula (3): wherein Al represents an aluminum atom, Ar1 and Ar2 each represent a substituted or unsubstituted aryl group or a heteroaryl group; and R1, R2 and R3 each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 8 carbon atom(s), an alkoxy group having 1 to 8 carbon atom(s), a substituted or unsubstituted aryl group, a dialkylamino group having 1 to 4 carbon atom(s), or a nitro group.Type: GrantFiled: January 15, 2002Date of Patent: August 10, 2004Assignee: Takasago International CorporationInventors: Takeshi Iwata, Yoshiki Okeda, Yoji Hori
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Patent number: 6664380Abstract: Free perfluorosulfonylmethide compounds and metal salts thereof show strong catalytic activity in carbon-carbon bond formation reactions, in amounts as low as 0.1 mole %. Fluorous media may be used, especially biphasic fluorous media enabling ready recycling of the catalyst. The formula thereof is: M[C(SO2R1)3−(m+q)(SO2R2)m(SO2R3)q]x where M is H, Sc, Y, La, Ce, Pr, Nd, Sm Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Zr, Hf, Th, Nb, Ta, U, Bi, Al, Ga, In or Tl, x is the common oxidation state of a said metal M, R1, R2 and R3 are perfluorinated or polyfluoronated hydrocarbon, ether or amine moieties or mixtures thereof and m+q=0, 1, 2 or 3 (m and q being zero or integers).Type: GrantFiled: February 19, 2002Date of Patent: December 16, 2003Assignee: The Institute of Applied CatalysisInventors: Anthony Gerard Martin Barrett, David Christopher Braddock, David Chadwick
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Publication number: 20030149293Abstract: A method for producing 1,3-cyclohexanediol compounds, particularly a 1,3-cyclohexanediol compound rich in cis-form. A 1,3-cyclohexanediol compound is reduced with a boron hydride compound such as sodium borohydride. Selectivity of cis-form is improved when an alkali metal compound and/or an alkaline earth metal compound, particularly a halide, is allowed to exist in the reaction system.Type: ApplicationFiled: February 5, 2003Publication date: August 7, 2003Applicant: MITSUBISHI CHEMICAL CORPORATIONInventors: Shuji Ichikawa, Hisao Urata, Shihomi Suzuki
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Patent number: 6552235Abstract: A method for producing cyclohexanol by subjecting cyclohexene to a hydration reaction in the presence of water using a solid acid as a catalyst in which as a reaction solvent, there is used an organic solvent having a solubility in water at 25° C. of not higher than 5% by weight, a boiling point which is at least 20° C. higher than that of the cyclohexanol produced, a conversion rate of not more than 3% under the hydration reaction conditions, and a solvent effect index of not less than 1.5 which indicates the effect of making the distribution of cyclohexene into the aqueous phase predominate.Type: GrantFiled: June 28, 2002Date of Patent: April 22, 2003Assignee: Asahi Kasei Kabushiki KaishaInventors: Yoshikazu Takamatsu, Tokitaka Kaneshima
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Patent number: 6515185Abstract: Cyclododecanone and cyclododecanol are produced each in high yield by reacting a epoxycyclododecane compound with hydrogen in the presence of a solid catalyst containing (a) catalytic component including a platinum group metal, (b) a promoter component including a VIII group, IIb group, IIIb group, IVb group, Vb group VIb group or VIIb group element or lanthanoid element or compound of the element, and (c) a carrier supporting the components (a) and (b) thereon.Type: GrantFiled: October 3, 2000Date of Patent: February 4, 2003Assignee: Ube Industries, Ltd.Inventors: Nobuyuki Kuroda, Hiroshi Shiraishi, Takato Nakamura
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Patent number: 6476278Abstract: Alcohols are produced in a practical and advantageous method, by the hydrogenation of a carbonyl compound under mild conditions, by reacting the carbonyl compounds with hydrogen in the presence of a bipyridyl derivative, a group VIII transition metal complex, and a base, or by reducing a carbonyl compound in the presence of a bipyridyl derivative, a group VIII transition metal complex, a base, and an alcoholic solvent.Type: GrantFiled: October 25, 2001Date of Patent: November 5, 2002Assignees: Japan Science and Technology Corporation, Takasago International CorporationInventors: Hideyuki Ikehira, Kunihiko Murata, Eiji Katayama, Masami Kozawa, Toru Yokozawa, Takeshi Ohkuma, Takao Ikariya, Ryoji Noyori
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Patent number: 6462206Abstract: Ketones and aldehydes are hydrogenated to the corresponding alcohol or alkyl group, using H2 gas as the stoichiometric reductant, and organometallic ruthenium complexes as the catalysts.Type: GrantFiled: June 20, 2001Date of Patent: October 8, 2002Assignees: E. I. du Pont de Nemours and Company, Brookhaven Science AssociatesInventors: R. Morris Bullock, Marcel Schlaf, Elisabeth M. Hauptman
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Patent number: 6441253Abstract: A process for the preparation of a compound having the formula: the process comprising treating a compound having the formula: with an alkyl metal species or with a Lewis acid in the presence of a tertiary amine base, wherein P2 is hydrogen or a hydroxyl protecting group.Type: GrantFiled: July 17, 2000Date of Patent: August 27, 2002Assignee: Florida State UniversityInventors: Robert A. Holton, Phong Vu, Tawfik Gharbaoui, Vincent Reboul
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Patent number: 6376722Abstract: A lutein to zeaxanthin isomerization process which includes a saponification or alkali treatment of a plant extract containing lutein followed by a heating period under controlled conditions, is carried out in the presence of a surface active agent having an HLB of from 1 to 40 as a catalyst for the lutein to zeaxanthin isomerization reaction, at a temperature between 70 to 140° C., in order to obtain a reaction product with high zeaxanthin concentrations of up to 80% of the total carotenoids.Type: GrantFiled: October 29, 1998Date of Patent: April 23, 2002Inventors: Vicente Ernesto Ridaura Sanz, Oscar Rubén García Correa, Armando Prado Naranjo
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Patent number: 6342645Abstract: The present invention relates to methods for the production and isolation of D-chiro-inositol (DCI) from kasugamycin. More specifically, the present invention relates to a method of producing DCI by hydrolysis of kasugamycin with aqueous trifluoroacetic acid in the presence of a strongly acidic ion exchange resin. The present invention further relates to methods of isolating DCI from an aqueous mixture, such as a hydrolysis mixture, either directly or by forming an organic derivative of DCI.Type: GrantFiled: December 29, 2000Date of Patent: January 29, 2002Assignee: Insmed Pharmaceuticals, Inc.Inventors: Robert Plourde, Jr., Mark C. Sleevi, Rachel K. Longo
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Patent number: 6329557Abstract: The present invention provides an industrial scale process for obtaining lutein and zeaxanthin concentrates of high purity from saponified marigold extracts that may have high levels of chlorophyll.Type: GrantFiled: June 9, 2000Date of Patent: December 11, 2001Assignee: Prodemex, S.A. de C.V.Inventors: Gustavo Rodriguez, Mario-David Torres-Cardona, Alejandro Diaz
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Patent number: 6310262Abstract: A new process prepares retiferol derivatives of formula I: wherein A is —C ≡C— or —CH═CH—, and R1 and R2 are independently of each other lower alkyl or lower perfluoroalkyl, one version couples ketones of formula 1I with compounds of formula III A second version couples phosphinoxides of formula IV with aldehydes of formula V. Compounds of formula I are useful in the treatment or prevention of hyperproliferative skin diseases and for reversing the conditions associated with photodamage.Type: GrantFiled: October 3, 2000Date of Patent: October 30, 2001Assignee: Basilea Pharmaceutica AGInventor: Hans Hilpert
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Patent number: 6291713Abstract: There is described a process of transferring &agr;,&bgr;-unsaturated alkyl groups to an electrophile (aldehyde, ketone, nitrile, imine, alkyne) by means of a masked zinc alkyl in an aprotic solvent.Type: GrantFiled: September 23, 1999Date of Patent: September 18, 2001Assignee: Metallgesellschaft AktiengesellschaftInventors: Philip Jones, Paul Knochel
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Patent number: 6262316Abstract: An oral preparation for the prophylactic and/or therapeutic treatment of inflammation in the mucous membrane of mammalian gastrointestinal tract (especially the human stomach) caused by Hicobacter sp. (especially H. pylori) infection is described. The preparation comprises a prophylactically and/or therapeutically effective amount of at least one type of xanthophylles. The most preferred xanthophyll is astaxanthin which is soluble in oil, preferably naturally produced astaxanthin which is esterified with fatty acids. The oral preparation may further comprise carbohydrate structures, such as those which derive from the cell wall of the production alga Haematococcus sp. The preparation may also comprise a prophylactically and/or therapeutically effective amount of a water soluble antioxidant, such as ascorbic acid (vitamin C). The oral preparation is presented in a separate unit dose or in mixture with food.Type: GrantFiled: January 21, 2000Date of Patent: July 17, 2001Assignee: Astacarotene ABInventors: Torkel Wadström, Pär Alejung
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Patent number: 6215031Abstract: The present invention relates to a 3-hydroxymethylcycloalkanol of the following formula (1), and a process for production of a 3-hydroxymethylcycloalkanol of the formula (1) by reduction of 3-formylcycloalkanone or 3-formylcycloalkenone. In accordance with the present invention, 3-hydroxymethylcycloalkanol, which is useful as the starting material for the production of polymers, can be produced with high conversion and high selectivity.Type: GrantFiled: September 24, 1998Date of Patent: April 10, 2001Assignee: Daicel Chemical Industries, Ltd.Inventors: Kenichi Yamamoto, Kazuyuki Matsuoka, Hiroshi Yagihara
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Patent number: 6207865Abstract: A carbonyl compound or a mixture of two or more carbonyl compounds is catalytically hydrogenated in the presence of a Raney copper catalyst in the form of nuggets.Type: GrantFiled: January 11, 2000Date of Patent: March 27, 2001Assignee: BASF AktiengesellschaftInventors: Boris Breitscheidel, Marc Walter, Detlef Kratz, Gerhard Schulz, Manfred Sauerwald
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Publication number: 20010000035Abstract: A process for the reaction of an organic compound in the presence of a catalyst comprising, as active metal, ruthenium alone or together with at least one Group Ib, VIIb, or VIIIb metal in an amount of from 0.01 to 30 wt %, based on the total weight of the catalyst, applied to a support, wherein from 10 to 50% of the pore volume of the support comprises macropores having a pore diameter in the range of from 50 nm to 10,000 nm and from 50 to 90% of the pore volume of the support comprises mesopores having a pore diameter in the range of from 2 to 50 nm, the sum of said pore volumes being 100%, and said catalyst as such.Type: ApplicationFiled: November 30, 2000Publication date: March 15, 2001Inventors: Thomas Ruhl, Boris Breitscheidel, Jochem Henkelmann, Andreas Henne, Rolf Lebkucher, Konard Knoll, Paul Naegele, Hermann Gausepohl, Sabine Weiguny, Norbert Niessner
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Patent number: 6107528Abstract: A bleach and oxidation catalyst is provided comprising a catalytically active iron complex which can activate hydrogen peroxide or peroxy acids, for example.Type: GrantFiled: December 2, 1998Date of Patent: August 22, 2000Assignee: Regents of the University of MinnesotaInventors: Lawrence Que, Jr., Cheal Kim, Jinheung Kim, Yan Zang
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Patent number: 6031140Abstract: A continuous process for preparing isocamphyl-cyclohexanols from isocamphy-guaiacol or isocamphyl-phenol compounds by hydrogenating one of said compounds with hydrogen at elevated temperature and elevated pressure, comprising the use of support-free molded bodies which serve as catalysts and which are obtainable by reduction of molded bodies made of compressed powders of cobalt, manganese and copper (hydr)oxides and optionally of (hydr)oxides of the alkaline earth metals are used.Type: GrantFiled: November 30, 1998Date of Patent: February 29, 2000Assignee: Bayer AktiengesellschaftInventors: Gerhard Darsow, Wilfried Niemeier
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Patent number: 6025323Abstract: The compounds of formula ##STR1## in which R stands for a methyl or ethyl group, are used as perfume ingredients for the preparation of perfuming compositions and perfumed articles, to which they confer aromatic and thujonic notes. The compounds can be used in the form of a mixture of enantiomers or in an enantiomerically pure state. The invention also comprises original processes for the preparation of these compounds.Type: GrantFiled: May 13, 1998Date of Patent: February 15, 2000Assignee: Firmenich SAInventors: Charles Fehr, Christian Margot
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Patent number: 5973211Abstract: A method of isomerizing lutein to yield a mixture of epimers of zeaxanthin includes the following steps: mixing a lutein-containing extract in a glycol solution to obtain a mixture, treating the mixture with alkali to obtain an alkali-containing mixture, reacting the alkali-containing mixture in the presence of heat for a duration consistent with achieving a desired level of isomerization of lutein to zeaxanthin.Type: GrantFiled: July 18, 1997Date of Patent: October 26, 1999Assignee: Prodemex, S.A. DE C.V.Inventor: Gustavo Rodriguez
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Patent number: 5959153Abstract: Process for decomposing a mixture containing cycloalkylhydroperoxide, which mixture includes an organic phase and an aqueous phase wherein, during the decomposition, at least one compound is present which meets the following parameters:A>-0.5 and B>-1.0 (1)A and B being dependent on T.sub.b, .rho., n.sub.d, .epsilon..sub.r, .delta..sub.d, .delta..sub.p, .delta..sub.h, .delta., .mu. and E.sub.T(30), where T.sub.b is the normal boiling point (.degree. C.), .rho. is the density measured at 25.degree. C. (kg/m.sup.3), n.sub.d is the refractive index (-), .epsilon..sub.r is the relative dielectric constant (-), .delta..sub.d is the Hansen solubility parameter for a dispersion (MPa.sup.1/2), .delta..sub.p is the Hansen solubility parameter for polarity (MPa.sup.1/2), .delta..sub.h is the Hansen solubility parameter for hydrogen bridges (MPa.sup.1/2), .delta. is the Scatchard-Hildebrant solubility parameter (MPa.sup.1/2), .mu. is the dipole moment (Debey), and E.sub.Type: GrantFiled: March 11, 1998Date of Patent: September 28, 1999Assignee: DSM N.V.Inventors: Ubaldus F. Kragten, Henricus A. C. Baur
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Patent number: 5942645Abstract: A process for hydrogenating aromatic compounds in which at least one hydroxyl group is bonded to an aromatic ring comprises bringing at least one of these compounds into contact with free hydrogen in the presence of a catalyst, wherein the catalyst comprises ruthenium and, if desired, at least one metal of transition groups I, VII and VIII in an amount of from 0.01 to 30% by weight, preferably from 0.2 to 15% by weight, based on the total weight of the catalyst, applied to a support, where the support has a mean pore diameter of at least 0.1 .mu.m, preferably at least 0.5 .mu.m, and a surface area of at most 15 m.sup.2 /g, preferably at most 10 m.sup.2 /g.Type: GrantFiled: February 3, 1997Date of Patent: August 24, 1999Assignee: BASF AktiengesellschaftInventors: Heinz Rutter, Thomas Ruhl, Boris Breitscheidel, Jochem Henkelmann, Thomas Wettling
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Patent number: 5932774Abstract: A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.Type: GrantFiled: November 6, 1995Date of Patent: August 3, 1999Assignee: Abbott LaboratoriesInventors: David A. Riley, Ashok V. Bhatia, Steven A. Chamberlin, Gregg E. Robinson
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Patent number: 5919986Abstract: Compounds of formula I: ##STR1## wherein the dotted carbon-carbon bond in the D-ring is C--C or C.dbd.C; C(R,R) is CH.sub.2 or C.dbd.CH.sub.2,R.sup.1 is H, F or OH,R.sup.2 and R.sup.3 are each independently C.sub.1-4 -alkyl or CF.sub.3, or together with the carbon to which they are bound form C.sub.3-6 -cycloalkyl.are useful in the treatment of vitamin D dependent disorders, such as psoriasis, leukemia; acne and seborrhoic dermatitis; osteoporosis hyperparathyroidism accompanying renal failure; and multiple sclerosis.Type: GrantFiled: October 13, 1998Date of Patent: July 6, 1999Assignee: Hoffmann-la Roche Inc.Inventors: Pierre Barbier, Franz Bauer, Peter Mohr, Marc Muller, Wolfgang Pirson
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Patent number: 5905173Abstract: The invention relates to a process for decomposing a mixture containing cycloalkyl hydroperoxide with an aqueous phase containing alkali metal hydroxide where, besides the alkali metal hydroxide, there is also at least 10 wt. % of the aqueous phase of one or more alkali metal salts. The alkali metal salts are preferably alkali metal carbonates, or alkali metal salts of mono- and poly-carboxylic acids, with the carboxylic acid moiety containing 1-24 carbon atoms.Type: GrantFiled: October 11, 1996Date of Patent: May 18, 1999Assignee: DSM NVInventors: Ubaldus F. Kragten, Henricus A.C. Baur, Johannes G.H.M. Housmans
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Patent number: RE40912Abstract: A method of isolating, purifying and recrystallizing substantially pure lutein, preferably from saponified marigold oleoresin in its pure free form, apart from chemical impurities and other carotenoids. Lutein may be used as an analytical standard or in cancer prevention trials and as a safe and effective color additive for human food.Type: GrantFiled: June 10, 2005Date of Patent: September 8, 2009Assignee: The Catholic University of AmericaInventor: Frederick Khachik
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Patent number: RE40931Abstract: A method of isolating, purifying and recrystallizing substantially pure lutein, preferably from saponified marigold oleoresin in its pure free form, apart from chemical impurities and other carotenoids. Lutein may be used as an analytical standard or in cancer prevention trials and as a safe and effective color additive for human food.Type: GrantFiled: January 10, 2006Date of Patent: October 6, 2009Assignee: The Catholic University of AmericaInventor: Frederick Khachik
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Patent number: RE40938Abstract: A method of isolating, purifying and recrystallizing substantially pure lutein, preferably from saponified marigold oleoresin in its pure free form, apart from chemical impurities and other carotenoids. Lutein may be used as an analytical standard or in cancer prevention trials and as a safe and effective color additive for human food.Type: GrantFiled: February 5, 2007Date of Patent: October 13, 2009Assignee: The Catholic University of AmericaInventor: Frederick Khachik