Benzene Ring Containing Patents (Class 570/182)
  • Publication number: 20150126779
    Abstract: This invention selectively synthesizes a cycloparaphenylene compound having 10, 11, or 13 benzene rings. The invention also synthesizes a cycloparaphenylene compound in which a functional group is introduced into a desired portion. By reacting specific raw materials using a specific reaction, a cyclic compound having 10, 11, or 13 bivalent aromatic hydrocarbon groups, bivalent heterocyclic groups, or derivative groups thereof can be selectively obtained as a pure substance.
    Type: Application
    Filed: March 7, 2013
    Publication date: May 7, 2015
    Inventors: Kenichiro Itami, Yasutomo Segawa, Haruka Omachi, Sanae Matsuura, Yusuke Nakanishi, Yuuki Ishii
  • Publication number: 20150110773
    Abstract: Methods and kits for GPP-targeting, e.g., for the treatment of oncogenic Kras-associated cancers, and methods for determining the efficacy of those methods are provided.
    Type: Application
    Filed: May 23, 2013
    Publication date: April 23, 2015
    Inventors: Alec C. Kimmelman, Jaekyoung Son, Lewis Cantley, Costas A. Lyssiotis
  • Publication number: 20150094492
    Abstract: The present invention relates to a process for preparing N-(5-chloro-2-isopropylbenzyl)cyclopropanamine by hydrogenation of N-[(5-chloro-2-isopropylphenyl)methylene]cyclopropanamine over specific platinum catalysts.
    Type: Application
    Filed: April 25, 2013
    Publication date: April 2, 2015
    Inventors: Thomas Himmler, Sandra Lehmann, Thomas Norbert Muller, Mathias Riedrich, Lars Rodefeld, Frank Volz, Sascha Von Morgenstern
  • Patent number: 8946492
    Abstract: A substituted alkenylbenzene compound of formula (4): wherein X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X3 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy and C1-C6alkylthio; X4 is selected from the group consisting of a hydrogen atom, halogen atom, cyano, C1-C4alkyl, C1-C4alkoxy and C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b independently of each other are a halogen atom, or R3a and R3b together form 3- to 6-membered ring together with the carbon atom bonding them by forming a C2-C5haloalkylene chain, and R3c is selected from the group consisting of a hydrogen atom, halogen atom, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy and C1-C4haloalkylthio, with a proviso that in case where X1
    Type: Grant
    Filed: March 25, 2013
    Date of Patent: February 3, 2015
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Takeshi Mita, Takamasa Kikuchi, Takashi Mizukoshi, Manabu Yaosaka, Mitsuaki Komoda
  • Publication number: 20150021586
    Abstract: This invention relates to deuterated aryl-anthracene compounds that are useful in electronic applications. It also relates to electronic devices in which the active layer includes such a deuterated compound.
    Type: Application
    Filed: October 8, 2014
    Publication date: January 22, 2015
    Inventors: DANIEL DAVID LECLOUX, Adam Fennimore, Weiying Gao, Nora Sabina Radu, Weishi Wu, Vsevolod Rostovtsev, Michael Henry Howard, JR., Hong Meng, Yulong Shen, Jeffrey A. Merlo, Eric Maurice Smith
  • Publication number: 20140301935
    Abstract: Oligophenylene monomers for the synthesis of polymeric precursors for the preparation of graphene nanoribbons, the polymeric precursors, and methods for preparing them, as well as methods for preparing the graphene nanoribbons from the polymeric precursors and the monomers are provided.
    Type: Application
    Filed: October 24, 2012
    Publication date: October 9, 2014
    Applicants: BASF SE, Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Sorin Ivanovici, Matthias Georg Schwab, Xinliang Feng, Klaus Muellen
  • Publication number: 20140301936
    Abstract: Provided are graphene nanoribbon precursors comprising repeated units of the general formula (I) in which R1, R2 are each H, halogen, —OH, —NH2, —CN, —NO2 or a hydrocarbyl radical which has 1 to 40 carbon atoms and may be linear or branched, saturated or unsaturated and mono- or poly-substituted by halogen (F, Cl, Br, I), —OH, —NH2, —CN, and/or —NO2, where one or more CH2 groups may also be replaced by —O—, —S—, —C(O)O—, —O—C(O)—, —C(O)—, —NH— or —NR—, in which R is an optionally substituted C1C40-hydrocarbyl radical, or an optionally substituted aryl, alkylaryl or alkoxyaryl radical.
    Type: Application
    Filed: October 24, 2012
    Publication date: October 9, 2014
    Applicants: BASF SE, Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Matthias Georg Schwab, Klaus Muellen, Xinliang Feng, Lukas Doessel
  • Publication number: 20140135374
    Abstract: Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
    Type: Application
    Filed: June 13, 2012
    Publication date: May 15, 2014
    Applicant: BIKAM PHARMACEUTICALS, INC.
    Inventor: David S. Garvey
  • Patent number: 8722942
    Abstract: A method produces a biphenyl derivative, with an industrially high yield and excellent productivity, by use of a raw material which is low in cost and toxicity. The method for producing the biphenyl derivative represented by Formula (1) is characterized in that a chlorine atom in a benzene derivative represented by Formula (2) reacts with magnesium metal to convert the benzene derivative into a Grignard reagent, and then the Grignard reagent is subjected to a coupling reaction in the presence of a catalyst and a dichloropropane: (wherein A represents at least one selected from alkyl groups, alkoxy groups, alkoxymethyl groups, a vinyl group, phenyl groups and chlorine, and n represents an integer of 1 to 4).
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: May 13, 2014
    Assignee: Toray Fine Chemicals Co., Ltd.
    Inventors: Tamio Hayashi, Jiro Nakatani
  • Patent number: 8685274
    Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: April 1, 2014
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventors: Tokifumi Masukawa, Yasuyuki Goto, Tomohiro Yano
  • Patent number: 8637678
    Abstract: The present invention relates to methods of initiating a reaction represented by scheme (1), wherein Q is optionally substituted aryl or optionally substituted heteroaryl; X is halogen or a sulphonate; P is an organic radical; R is hydrogen or an organic radical; wherein the catalyst comprises copper and a ligand; comprising providing the compound of formula III in liquid form prior to contacting the compound of formula III with the catalyst.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: January 28, 2014
    Assignee: Syngenta Limited
    Inventors: George Robert Hodges, Lisa Mitchell, Alan James Robinson
  • Publication number: 20130337196
    Abstract: The present invention discloses a liquid crystal (LC) molecule having a five-membered ring structure and a mixture thereof. A traditional LC molecule is modified into the LC molecule having the five-membered ring structure. The rotational viscosity of the LC molecule within an LC panel is decreased by properties of the five-membered ring structure, so that the LC molecule having the five-membered ring structure has a fast off-time than that of the traditional LC molecule. The present invention can decrease the rotational viscosity of the LC molecule within the LC panel by modification of the five-membered ring structure of the LC molecule, and thus the problem of cross-talk effect produced from switching a two-dimensional mode to a three-dimensional mode in an LC display can be improved.
    Type: Application
    Filed: July 2, 2012
    Publication date: December 19, 2013
    Applicant: Shenzhen China Star Optopelectronics Technology Co., Ltd.
    Inventor: Chung-Ching Hsieh
  • Patent number: 8575285
    Abstract: Provided is a catalyst used for a living radical polymerization method, which contains a central element consisting of carbon and at least one halogen atom binding to the central element. Further, a hydrocarbon compound can be used as a catalyst precursor. A monomer having a radical-reactive unsaturated bond is subjected to a radical polymerization reaction in the presence of the catalyst, consequently a polymer having narrow molecular weight distribution can be obtained, and thus the cost of the living radical polymerization can be remarkably reduced. The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages such as low toxicity of the catalyst, low amount of the catalyst used, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor (no need of any post-treatments for a molded article), and the like.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: November 5, 2013
    Assignee: Kyoto University
    Inventors: Atsushi Goto, Yoshinobu Tsujii, Takeshi Fukuda
  • Publication number: 20130277611
    Abstract: The present invention relates to compounds containing at least three ring systems, at least one of which is a 2,6-naphthylene group, and two unsaturated bridging groups between the ring systems, and to the use of the compounds for high-frequency components, in particular antennae, especially for the gigahertz region. The liquid-crystalline media comprising these compounds serve, for example, for the phase shifting of microwaves for tuneable ‘phased-array’ antennae.
    Type: Application
    Filed: December 14, 2011
    Publication date: October 24, 2013
    Applicant: MERCK PATENT GmbH
    Inventors: Christian Jasper, Elvira Montenegro, Detlef Pauluth, Volker Reiffenrath, Atsutaka Manabe
  • Patent number: 8513346
    Abstract: A method for flame-retarding styrenic resins is disclosed wherein the method comprises incorporating in compositions an effective amount of at least one flame retardant compound comprising both aliphatic and aromatic bromine.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: August 20, 2013
    Assignee: Chemtura Corporation
    Inventors: Stephen B. Falloon, David W. Bartley, Julia E. Holland, Wayne Meyer, Steven Bakeis
  • Patent number: 8487136
    Abstract: A method for selectively producing a monoaryl norbornene derivative represented by a formula (5) involves having a norbornadiene derivative represented by a formula (3) and a bromine compound represented by a formula (4) react with each other in the presence of a reducing agent, palladium and at least one selected from phosphorus compounds represented by the formulas (1) and (2), whereby the norbornene derivative represented by formula (5) having a monoaryl substituent is an exo configuration.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: July 16, 2013
    Assignee: Nippon Oil Corporation
    Inventors: Shinichi Komatsu, Toshikatsu Shoko, Tadahiro Kaminade
  • Publication number: 20130165658
    Abstract: This invention is directed to a process for the preparation of high yield alkyl or aryl iodide from its corresponding carboxylic acid using N-iodo amides.
    Type: Application
    Filed: June 9, 2011
    Publication date: June 27, 2013
    Inventors: Gennady Nisnevich, Mark Gandelman, Kseniya Kulbitski
  • Patent number: 8471013
    Abstract: The present invention provides a process for reacting between a phenol derivative and an aromatic substrate under phenolate forming conditions comprising the following steps: (a) reacting a phenol derivative with a base in a polar organic solvent to obtain a phenolate salt, wherein water is removed form the reaction mixture during the reaction, (b) adding the aromatic substrate to the reaction mixture obtained in step (a), (c) heating the reaction mixture of step (b) to a temperature in the range of 80° to 1300° C., preferably, 90° to 1000° C. for 2 to 7 hours to obtain a phenoxy substituted aromatic substrate, (d) removing the solvent from the mixture of step (c) and optionally further isolating an purifying the phenoxy substituted aromatic substrate. Optionally, the removal of water during step (a) is in conjunction with partial removal of the organic solvent.
    Type: Grant
    Filed: December 16, 2007
    Date of Patent: June 25, 2013
    Assignee: Makhteshim Chemical Works, Ltd.
    Inventors: David Ovadia, Raya Sturkovich, David Leonov
  • Publication number: 20130150607
    Abstract: This invention is directed to a new process for making an alkylaromatic compound. In an embodiment of this invention, the process is directed to selective synthesizing an alkylaromatic compound comprising a high amount of dialkylate product. In general, this process involves contacting at least one alkylatable aromatic compound with an alkylating agent and a catalyst under suitable reaction conditions such that the resulting reactor effluent prior to any stripping step may be characterized by a dialkylate product content of at least 44 wt % and a trialkylate and higher polyalkylate product content of no more than 20 wt %. The alkylaromatic compounds produced have excellent thermal and oxidative stabilities, good additive solvency, and improved seal compatibility while maintaining good VI and low temperature properties. They are useful as lubricant basestocks and lubricant additives.
    Type: Application
    Filed: December 7, 2011
    Publication date: June 13, 2013
    Inventor: Beth A. WINSETT
  • Publication number: 20130146852
    Abstract: Light-emitting and/or charge transporting polymers, methods of making the same, and organic light emitting devices comprising such polymers, the polymers comprising a repeat unit of formula (I): —(Ar)q-Sp-CT-Sp-(Ar)q—??(I) in which CT represents a conjugated charge-transporting group, each Ar independently represents an optionally substituted aryl or heteroaryl group, q is at least 1, and each Sp independently represents a spacer group forming a break in conjugation between Ar and CT.
    Type: Application
    Filed: May 12, 2011
    Publication date: June 13, 2013
    Applicants: SUMITOMO CHEMICAL COMPANY LIMITED, CAMBRIDGE DISPLAY TECHNOLOGY LIMITED
    Inventors: Annette Steudel, Richard Owoare
  • Patent number: 8362127
    Abstract: A halogenated non-polymeric phenyl ether flame retardant is described having the general formula (I): wherein each X is independently Cl or Br, n is an integer of 1 or 2, and each p is independently an integer of 1 to 4, provided that, when each X is Cl, the total amount halogen in the ether is from about 50 to about 65 wt % and when each X is Br, the total amount halogen in the ether is from at least 70 wt % to about 79 wt % and wherein from about 30% to about 80%, for example from about 35% to about 75% of the halogenated ethers are fully halogenated the remainder being partially halogenated. The present flame retardant provides superior mechanical properties when incorporated into a polymer than similar flame retardants which contain a higher amount of fully halogenated species.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: January 29, 2013
    Assignee: Chemtura Corporation
    Inventors: Larry D. Timberlake, James D. Siebecker, Subramaniam Narayan
  • Patent number: 8357738
    Abstract: A flame retardant blend comprises at least first and second halogenated non-polymeric phenyl ethers having the general formula (I): wherein each X is independently Cl or Br, each m is independently an integer of 1 to 5, each p is independently an integer of 1 to 4, n is an integer of 1 to 5 and wherein the values of n for the first and second ethers are different.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: January 22, 2013
    Assignee: Chemtura Corporation
    Inventors: Larry D. Timberlake, James D. Siebecker
  • Patent number: 8344028
    Abstract: Gamma-amino-butyric acid derivatives that are GABAB receptor ligands, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives and pharmaceutical compositions thereof for treating diseases are disclosed.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: January 1, 2013
    Assignee: XenoPort, Inc.
    Inventors: Feng Xu, Mark A. Gallop, Ge Peng, Thu Phan, Usha Dilip, David J. Wustrow
  • Publication number: 20120246759
    Abstract: The present invention relates to the field of the production of transgenic plants through Agrobacterium-mediated transformation of cells of somatic embryogenic calli or embryogenic suspension cultures and regeneration of the transformed cells into fruit-setting plants. In particular, the present invention relates to the production of transgenic plants in the Euphorbiaceae family. The present invention further relates to media compositions, selection methods and engineered Agrobacterium tumefaciens strains that improve Agrobacterium-mediated transformation efficiency.
    Type: Application
    Filed: December 4, 2009
    Publication date: September 27, 2012
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Lin Cai, Longhua Sun, Lin Fu, Lianghui Ji
  • Publication number: 20120196908
    Abstract: This invention describes new antifungal compounds that are aralkyl benzyl ethers of the formula (I): wherein: Ar represents aryl, imidazolil, 1,2,4-triazolyl, benzimidazolil; R1, R2, R4 and R5 are independently hydrogen, halogen, C1-6 alkyl; R3 represents halogen, C1-6alkyl or O—R? where R? represents hydrogen or lower alkyl; R6 represents aryl, substituted aryl, trifluoromethyl, trichloromethyl or O—R? where R? represents hydrogen or lower alkyl; being the substituents of the aryl a halogen or a radical tetrazolyl; n and m represent independently an integer between 0 and 5; With the proviso that when Ar is imidazolil, R3 is chlorine, R6 is p-phenyl and R1, R2, R4 and R5 are hydrogen, n must be different from 2. When n and m are not 0 and 1, R3 or R6 can be represented by substituents not necessarily equal.
    Type: Application
    Filed: August 27, 2010
    Publication date: August 2, 2012
    Applicant: BIOLAB SANUS FARMACEUTICA LTDA.
    Inventors: Artur Franz Keppler, Sérgio Luiz Sacurai, Marcio Henrique Zaim, Carlos Eduardo da Costa Touzarim
  • Patent number: 8084654
    Abstract: Disclosed is a method for preparing an iodinated aromatic compound. More specifically, disclosed is a method of preparing an iodinated aromatic compound by iodinating an aromatic compound in the presence of oxygen over a zeolite catalyst, in which the aromatic compound and its monoiodo compound, as raw materials, are allowed to react with iodine. In comparison with a method in which only the aromatic compound is used as a raw material without adding the monoiodo compound, the disclosed method can increase the productivity of diiodo compounds and the selectivity to a p-diiodo compound and, at the same time, suppress side reactions, thus lengthening the life span of the catalyst.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: December 27, 2011
    Assignee: SK Chemicals Co., Ltd.
    Inventors: Han Seok Kim, Jong In Lee, Il Hoon Cha, Yoon Seo Lee
  • Publication number: 20110309300
    Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.
    Type: Application
    Filed: June 10, 2011
    Publication date: December 22, 2011
    Applicants: CHISSO PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Tokifumi MASUKAWA, Yasuyuki GOTO, Tomohiro YANO
  • Publication number: 20110272628
    Abstract: A preparation, comprising a mixture of dibenzoyl peroxides where the mixture of dibenzoyl peroxides contains 50 to 99.7 mole % of a symmetric dibenzoyl peroxide and 0.3 to 50 mole % asymmetric dibenzoyl peroxides, shows a reduced decomposition temperature of the peroxides compared to the symmetric dibenzoyl peroxide and is suitable for hot cross-linking silicone rubber. The preparation can be produced by reacting a mixture containing a first benzoyl chloride and a second benzoyl chloride that is different therefrom with hydrogen peroxide, wherein the mixture of benzoyl chlorides contains 70 to 99.7 mole % of the first benzoyl chloride and 0.3 to 30 mole % of the second benzoyl chloride.
    Type: Application
    Filed: June 4, 2009
    Publication date: November 10, 2011
    Inventors: Josef Helmut Weinmaier, Dominik Hermann, Martin Kunz
  • Publication number: 20110275775
    Abstract: Provided is a catalyst used for a living radical polymerization method, which contains a central element consisting of carbon and at least one halogen atom binding to the central element. Further, a hydrocarbon compound can be used as a catalyst precursor. A monomer having a radical-reactive unsaturated bond is subjected to a radical polymerization reaction in the presence of the catalyst, consequently a polymer having narrow molecular weight distribution can be obtained, and thus the cost of the living radical polymerization can be remarkably reduced. The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages such as low toxicity of the catalyst, low amount of the catalyst used, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor (no need of any post-treatments for a molded article), and the like.
    Type: Application
    Filed: September 8, 2009
    Publication date: November 10, 2011
    Applicant: Kyoto University
    Inventors: Atsushi Goto, Yoshinobu Tsujii, Takeshi Fukuda
  • Publication number: 20110263869
    Abstract: The present invention relates to methods of initiating a reaction represented by scheme (1), wherein Q is optionally substituted aryl or optionally substituted heteroaryl; X is halogen or a sulphonate; P is an organic radical; R is hydrogen or an organic radical; wherein the catalyst comprises copper and a ligand; comprising providing the compound of formula III in liquid form prior to contacting the compound of formula III with the catalyst.
    Type: Application
    Filed: December 16, 2009
    Publication date: October 27, 2011
    Applicant: SYNGENTA CROP PROTECTION, LLC
    Inventors: George Robert Hodges, Lisa Mitchell, Alan James Robinson
  • Publication number: 20110224320
    Abstract: New branched or star-branched styrene polymeric, telomeric, and monomeric product distributions, their preparation, their use as raw materials for bromination to produce flame retardants, the flame retardants themselves, and their use as flame retardants in various polymeric substrates are described.
    Type: Application
    Filed: November 30, 2009
    Publication date: September 15, 2011
    Applicant: ALBEMARLE CORPORATION
    Inventors: William J. Layman, JR., Charles H. Kolich, Arthur G. Mack, Jonathan P. McCarney, Govindarajulu Kumar, Junzuo Wang, Jorge Morice, Zhongxin Ge, Bo Liu, Ravindra R. Joshi, Hoover B. Chew, Douglas W. Luther, Kimberly M. White
  • Publication number: 20110121269
    Abstract: This invention relates to deuterated aryl-anthracene compounds that are useful in electronic applications. It also relates to electronic devices in which the active layer includes such a deuterated compound.
    Type: Application
    Filed: May 19, 2010
    Publication date: May 26, 2011
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: DANIEL DAVID LECLOUX, ADAM FENNIMORE, WEIYING GAO, NORA SABINA RADU, WEISHI WU, VSEVOLOD ROSTOVTSEV, MICHAEL HENRY HOWARD, JR., HONG MENG, YULONG SHEN
  • Publication number: 20110105539
    Abstract: A process for obtaining 2?-halo-4-methylbiphenyls is described, which comprises reacting 4 halotoluene with a 1,2-dihalobenzene in the presence of elemental metal such as magnesium, lithium or zinc, wherein 0 to 0.9 molar, particularly 0 to 0.2 molar excess of 4-halotoluene in regard to 1,2-dihalobenzene is used, and arised organometal intermediates are quenched by elemental mental halogen. In addition, the coupling of arised 2?-halo-4-methylbiphenyls with 2-(1-propyl)-4-methyl-6-(1?-methylbenzimidazole-2-il)benzimidazole to afford 3?-(2?-halo-biphenyl-4-ylmethyl)-1,7?-dimethyl-2?-propyl-1H,3?H-[2,5?]bibenzoimidazolyl, which can be further converted to organometallic compound and said organometallic compound is further reacted with formic acid derivative, such as N,N-dimethylformamide, alkylformiate or carbon dioxide to obtain telmisartan, is also described.
    Type: Application
    Filed: March 19, 2009
    Publication date: May 5, 2011
    Applicant: LEK Pharmaceuticals D.D.
    Inventors: Anton Copar, Zdenko Casar, Andrej Premrl
  • Publication number: 20100314582
    Abstract: The present invention relates to dielectrically positive liquid-crystalline media comprising one or more compounds of the formula I in which the parameters have the meaning indicated in the specification, and optionally one or more compounds selected from the group of the compounds of the formulae II and III in which the parameters have the meaning indicated in the specification, and optionally one or more compounds of the formula IV in which the parameters have the meaning indicated in the specification, and to liquid-crystal displays containing these media, especially to active-matrix displays and in particular to TN, IPS and FFS displays.
    Type: Application
    Filed: January 23, 2009
    Publication date: December 16, 2010
    Inventors: Michael Wittek, Markus Czanta, Atsutaka Manabe, Lars Lietzau, Marcus Reuter, Brigitte Schuler, Elisabeth Meyer
  • Patent number: 7851662
    Abstract: High assay reaction-derived decabromodiphenylethane product is produced and provided. The process comprises feeding diphenylethane, a partially brominated diphenylethane, or both subsurface into the liquid phase of a reaction mixture formed from components comprising excess liquid bromine and aluminum-based Lewis acid bromination catalyst. The temperature of the reaction mixture, the catalyst concentration in the excess bromine in the reaction mixture, and the feed time are coordinated in the processes to produce high assay reaction-derived decabromodiphenylethane product. Ways of effecting such coordination are described.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: December 14, 2010
    Assignee: Albemarle Corporation
    Inventor: Bonnie Gary McKinnie
  • Patent number: 7837774
    Abstract: Biocide compositions capable of increasing the fading resistance of a coating material, which compositions preferably comprise a nano-sized halogenated benzonitrile and a nano-sized zinc oxide, are disclosed. Coating compositions, which comprise the biocide compositions, binders, and pigments are disclosed. The biocide compositions are particularly suitable for use in paints. Methods for reducing the fading of pigmented coating compositions upon exposure to light are also disclosed.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: November 23, 2010
    Assignee: Cognis IP Management GmbH
    Inventors: Kenneth Breindel, Shailesh Shah, Ayaz A. Khan
  • Publication number: 20100260934
    Abstract: A composition comprising perfluoro-[2,2]-paracyclophane dimer compound is disclosed. The synthesis reaction of the paracyclophane dimer from 1,4-bis(chlorodifluoromethane)-2,3,5,6-tetrafluorobenzene involves heating in the presence of a metal catalyst and a solvent. A perfluorinated paraxylylene coating formed from the perfluorinated paracyclophane dimer is also disclosed.
    Type: Application
    Filed: July 27, 2009
    Publication date: October 14, 2010
    Applicant: SPECIALITY COATING SYSTEMS, INC.
    Inventors: William R. Dolbier, JR., Puhui Xie, Rakesh Kumar
  • Patent number: 7763760
    Abstract: A method for ring-halogenating an aromatic compound comprises contacting with chlorine or bromine, a mixture comprising the aromatic compound and a mixed copper salt of formula Cu(Y)X, where Y comprises a counterion derived from an organic acid, where the organic acid has a pKa relative to water of 0 or greater; and X comprises Cl, Br, I, or (SO42?)1/2; to produce a reaction mixture comprising a haloaromatic compound and a copper(II) halide residue.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: July 27, 2010
    Assignee: SABIC Innovative Plastics IP B.V.
    Inventors: Balakrishnan Ganesan, Pradeep Jeevaji Nadkarni
  • Patent number: 7758931
    Abstract: Such a liquid crystal compound is provided that has stability to heat, light and so forth, has a nematic phase in a wide temperature range, has a small viscosity, a suitable optical anisotropy, and suitable elastic constants K33 and K11 (K33: bend elastic constant, K11: splay elastic constant), and has suitable negative dielectric anisotropy and excellent compatibility with other liquid crystal compounds. A liquid crystal composition containing the liquid crystal compound, and a liquid crystal display device containing the liquid crystal composition are also provided.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: July 20, 2010
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventors: Yasuyuki Goto, Teru Shimada, Teruyo Sugiura
  • Publication number: 20100029935
    Abstract: The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an ?-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt having axial asymmetry of the present invention is a chiral phase-transfer catalyst that has a simple structure and that can be produced in a smaller number of process steps. The compound of the present invention is very useful as a phase-transfer catalyst in the synthesis of an ?-alkyl-?-amino acid and a derivative thereof as well as an ?,?-dialkyl-?-amino acid and a derivative thereof. Therefore, the compound of the present invention can be used in the development of novel foods and pharmaceuticals.
    Type: Application
    Filed: September 13, 2007
    Publication date: February 4, 2010
    Applicant: Nagase & Co., Ltd.
    Inventors: Keiji Maruoka, Kenichiro Yamamoto, Yukifumi Nishimoto
  • Patent number: 7642374
    Abstract: The present invention provides a process for producing 5-iodo-2-methylbenzoic acid through iodination of 2-methylbenzoic acid, the process including, as essential steps, a reaction step of iodinating 2-methylbenzoic acid in the presence of a microporous compound, iodine, an oxidizing agent, and acetic anhydride, and a purification step including sublimation, distillation, crystallization, or a combination of two or more of these. According to the present invention, 5-iodo-2-methylbenzoic acid, which is useful for producing functional chemicals such as drugs, can be produced at high purity and high yield in a simple manner. Since the production process includes a simple reaction step and a simple separation/purification step, the load of purification is mitigated. In addition, the microporous compound such as a zeolite catalyst which has been separated and recovered from the reaction mixture can be repeatedly employed after performing of a simple treatment.
    Type: Grant
    Filed: July 1, 2004
    Date of Patent: January 5, 2010
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Takafumi Yoshimura, Toshio Hidaka, Yoshifumi Sato, Norio Fushimi, Kazuhiro Yamada
  • Patent number: 7625988
    Abstract: The present invention is directed to novel flame retardant monomers and polymers, wherein the flame retardant properties of the polymers are provided by functionality in pendant groups attached to a polymer backbone (as opposed to the polymer backbone itself possessing flame retardant properties. The present invention is also directed to methods of making such polymers and monomers, and articles of manufacture incorporating such monomers and polymers.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: December 1, 2009
    Assignee: William Marsh Rice University
    Inventors: James M. Tour, Joshua L. Jurs, Jason J. Stephenson
  • Publication number: 20090285987
    Abstract: A composition comprising perfluoro-[2,2]-paracyclophane dimer compound is disclosed. The synthesis reaction of the paracyclophane dimer from 1,4-bis(chlorodifluoromethane)-2,3,5,6-tetrafluorobenzene involves heating in the presence of a metal catalyst and a solvent. A perfluorinated paraxylylene coating formed from the perfluorinated paracyclophane dimer is also disclosed.
    Type: Application
    Filed: July 27, 2009
    Publication date: November 19, 2009
    Applicant: SPECIALITY COATING SYSTEMS, INC.
    Inventors: William R. Dolbier, JR., Puhui Xie, Rakesh Kumar
  • Publication number: 20090266995
    Abstract: The present invention provides methods and compositions for modulating x-ray attenuation, where the x-ray attenuation compound can comprise a molecule having at least two conformational states, a first k-edge atom attached to the molecule at a first position, and a second k-edge atom attached to the molecule at a second position, where the molecule changes from a first conformational state to a second conformational state in response to an external stimulus. Additionally, a first interatom distance between the first k-edge atom and the second k-edge atom in the first conformational state can be within a first harmonic error of 0 to about 0.2, and a second interatom distance between the first k-edge atom and the second k-edge atom in the second conformational state can be within a second harmonic error of about 0.8 to 1.0.
    Type: Application
    Filed: April 14, 2009
    Publication date: October 29, 2009
    Inventors: Steven Poelzing, Rengasayee Veeraraghavan, Adam Smoot
  • Publication number: 20090261300
    Abstract: There are provided a heteroacene derivative having an excellent oxidation resistance and capable of forming a semiconductor active phase by a coating process, and an oxidation-resistant organic semiconductor material using the same, as well as an organic thin film.
    Type: Application
    Filed: August 28, 2007
    Publication date: October 22, 2009
    Applicant: TOSOH CORPORATION
    Inventor: Makoto Watanabe
  • Patent number: 7605207
    Abstract: Polybrominated bisaryl compounds containing bromomethyl or bromomethylene groups are provided, as well as flameproof polymeric formulations comprising the compounds. The novel compounds exhibit a good thermal stability, and are particularly suitable for flame-retarding polystyrene thermoplastic foams. A process for making the polybrominated bisaryl compounds is also provided.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: October 20, 2009
    Assignee: Bromine Compounds Ltd.
    Inventors: Jakob Oren, Nasif Yassin, Joseph Zilberman, Dorit Canfi, Ron Frim, Dov Beruben
  • Patent number: 7601878
    Abstract: A solid catalyst used in, for example, production of a perfluoroalkyl iodide telomer is effectively and continuously recovered and the recovered catalyst is continuously recycled to the reactor for reuse. A slurry containing a reaction product and the catalyst is drawn from the reaction system, and the catalyst in the drawn slurry is classified by means of a hydrocyclone, whereby a high-concentration slurry whose catalyst concentration is higher than that of the drawn slurry and a low-concentration slurry whose catalyst concentration is lower than that of the drawn slurry are obtained, and the high-concentration slurry is recycled to the reaction system.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: October 13, 2009
    Assignee: Daikin Industries, Ltd.
    Inventors: Tatsuya Hirata, Kouzou Noda, Jun Miki
  • Patent number: 7592407
    Abstract: A polymerizable fluorinated compound having formula (2a) or (2b) wherein R1 and R2 are H or C1-C20 alkyl or fluoroalkyl, R3 is H, F or C1-C4 alkyl or fluoroalkyl, and R is H or a protective group is polymerized into a fluorinated polymer which is used as a base polymer to formulate a resist composition having transparency to laser light of wavelength?300 nm, alkali development amenability, and dry etch resistance.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: September 22, 2009
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Yuji Harada, Jun Hatakeyama, Takeru Watanabe, Takeshi Kinsho
  • Patent number: 7465842
    Abstract: The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: December 16, 2008
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Pei-Pei Kung, Carlos Martinez, Junhua Tao
  • Publication number: 20080281024
    Abstract: Polybrominated bisaryl compounds containing bromomethyl or bromomethylene groups are provided, as well as flameproof polymeric formulations comprising the compounds. The novel compounds exhibit a good thermal stability, and are particularly suitable for flame-retarding polystyrene thermoplastic foams. A process for making the polybrominated bisaryl compounds is also provided.
    Type: Application
    Filed: November 16, 2006
    Publication date: November 13, 2008
    Applicant: BROMINE COMPOUNDS LTD.
    Inventors: Jakob Oren, Nasif Yassin, Joseph Zilberman, Dorit Canfi, Ron Frim, Dov Beruben