Product Patents (Class 570/181)
  • Patent number: 9012704
    Abstract: A method for preparing 13C labeled iodotridecane represented by Formula A: The method comprises the conversion of 13C labeled propargyl alcohol to 13C labeled iodotridecane via alkylation of propargyl alcohol with iododecane.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: April 21, 2015
    Assignee: Phenomenome Discoveries Inc.
    Inventors: M. Amin Khan, Paul L. Wood, Dayan Goodenowe
  • Patent number: 9000243
    Abstract: The present invention relates to a process for separating chlorinated methanes utilizing a dividing wall column. Processes and manufacturing assemblies for generating chlorinated methanes are also provided, as are processes for producing products utilizing the chlorinated methanes produced and/or separated utilizing the present process(es) and/or assemblies.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: April 7, 2015
    Assignee: Dow Global Technologies LLC
    Inventors: John G Pendergast, Jr., William S. White, Anthony R. Avilla, Thomas U Luebbe
  • Patent number: 8907083
    Abstract: The invention provides a novel process for the synthesis of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one, the process comprising of reacting the salicylic acid with salicylamide in the presence of p-toluenesulfonyl chloride, base and solvent. The use of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one in the preparation of Deferasirox is also disclosed in the invention.
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: December 9, 2014
    Assignee: Ramamohan Rao Davuluri
    Inventors: Ramamohan Rao Davuluri, Ravi Ponnaiah, Guruswamy Batthni, Chandra Murthy V. R. Medida, Santhosh Dummu
  • Publication number: 20140357069
    Abstract: A novel method and system for using aluminum dopant compositions is provided. A composition of the aluminum dopant compositions is selected with sufficient vapor pressure and minimal carbon content, thereby enabling ease of delivery to an ion implant process and substantial reduction of carbon deposition during Al ion implantation. The source material is preferably stored and delivered from a sub-atmospheric storage and delivery device to enhance safety and reliability during the Al ion implantation process.
    Type: Application
    Filed: May 27, 2014
    Publication date: December 4, 2014
    Inventors: Ashwini K. Sinha, Lloyd A. Brown
  • Publication number: 20140315768
    Abstract: This disclosure is directed to an additive package for a lubricant composition that provides improved compatibility with fluoropolymer seals. The additive package comprises a seal compatibility additive. The disclosure is also directed to a lubricant composition comprising a base oil and a seal compatibility additive. The seal compatibility additive improves the compatibility with fluoropolymer seals of the resultant lubricant composition.
    Type: Application
    Filed: April 22, 2014
    Publication date: October 23, 2014
    Inventors: Kevin DeSantis, Michael Hoey, Al Jung, Phil Rabbat, David Chasan, Stephen Jones
  • Publication number: 20140309464
    Abstract: A method for preparing 13C labeled iodotridecane represented by Formula A. The method comprises the conversion of 13C labeled propargyl alcohol to 13C labeled iodotridecane via alkylation of propargyl alcohol with iododecane.
    Type: Application
    Filed: November 16, 2012
    Publication date: October 16, 2014
    Inventors: M. Amin Khan, Paul L. Wood, Dayan Goodenowe
  • Patent number: 8779221
    Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: July 15, 2014
    Assignee: Promega Corporation
    Inventors: Aldis Darzins, Lance Encell, Tonny Johnson, Dieter Klaubert, Georgyi V. Los, Mark McDougall, Keith V. Wood, Monika G. Wood, Chad Zimprich
  • Patent number: 8765011
    Abstract: To provide a liquid crystal compound having general physical properties required for the compound, namely, a high stability to heat, light and so forth, a small viscosity, a refractive index anisotropy value having a suitable magnitude, a dielectric constant anisotropy value having a suitable magnitude and steep electro-optical characteristics, a wide temperature range of a nematic phase, and an excellent compatibility with other liquid crystal compounds, in particular, a liquid crystal compound having a wide temperature range of the nematic phase; the compound is represented by formula (1): wherein R is alkenyl having 2 to 20 carbons; ring A1 and ring A2 are independently 1,4-cyclohexylene, or 1,4-phenylene in which at least one of hydrogen may be replaced by fluorine; Z1 and Z2 are independently a single bond, —CH2CH2—, —CH?CH—, —CH2O— or —OCH2—; and n is 0 or 1.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: July 1, 2014
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventors: Teizi Satou, Yasuyuki Goto
  • Publication number: 20140128583
    Abstract: Disclosed is an anti-infective drug-macrolide derivate, preparation and uses thereof. Macrolide derivate, namely erythromycin ethylsuccinate crystalline hydrate, which has less moisture absorption and good storage stability, can be used in the preparation of medicaments for the treatment and prevention of human or animal infectious diseases caused by Gram-positive or negative bacteria.
    Type: Application
    Filed: April 20, 2012
    Publication date: May 8, 2014
    Inventor: Li Liu
  • Publication number: 20140113811
    Abstract: Provided are methods for storing gases on porous adsorbents, methods for optimizing the storage of gases on porous adsorbents, methods of making porous adsorbents, and methods of gas storage of optimized compositions, as in systems containing porous adsorbents and gas adsorbed on the surface of the porous adsorbent. The disclosed methods and systems feature a constant or increasing isosteric enthalpy of adsorption as a function of uptake of the gas onto the exposed surface of a porous adsorbent. Adsorbents with a porous geometry and surface dimensions suited to a particular adsorbate are exposed to the gas at elevated pressures in the specific regime where n/V (density) is larger than predicted by the ideal gas law by more than several percent.
    Type: Application
    Filed: October 10, 2013
    Publication date: April 24, 2014
    Inventors: Nicholas P. STADIE, Brent T. FULTZ, Channing AHN, Maxwell MURIALDO
  • Publication number: 20140011973
    Abstract: The invention discloses a compound having branching alkyl chains, the method for preparing the same and use thereof in photoelectric devices. By applying the branching alkyl chains as the solubilizing group to the preparation of organic conjugated molecules (for example, organic conjugated polymers), the number of methylenes between the resultant alky side chains and the backbone, i.e., m>1, which can effectively reduce the effect of the alkyl chains on the backbone ?-? stacking, thereby ensuring the solubility of the organic conjugated molecule while greatly increasing the mobility of their carriers. It is suitable for an organic semiconductor material in photoelectric devices such as organic solar cells, organic light emitting diodes and organic field effect transistors, etc.
    Type: Application
    Filed: July 5, 2013
    Publication date: January 9, 2014
    Inventors: Jian PEI, Ting LEI, Jinhu DOU
  • Publication number: 20130338356
    Abstract: The invention provides a novel process for the synthesis of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one, the process comprising of reacting the salicylic acid with salicylamide in the presence of p-toluenesulfonyl chloride, base and solvent. The use of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one in the preparation of Deferasirox is also disclosed in the invention.
    Type: Application
    Filed: August 23, 2011
    Publication date: December 19, 2013
    Inventors: Ramamohan Rao Davuluri, Ravi Ponnaiah, Guruswamy Batthni, Chandra Murthy V. R. Medida, Santhosh Dummu
  • Patent number: 8575285
    Abstract: Provided is a catalyst used for a living radical polymerization method, which contains a central element consisting of carbon and at least one halogen atom binding to the central element. Further, a hydrocarbon compound can be used as a catalyst precursor. A monomer having a radical-reactive unsaturated bond is subjected to a radical polymerization reaction in the presence of the catalyst, consequently a polymer having narrow molecular weight distribution can be obtained, and thus the cost of the living radical polymerization can be remarkably reduced. The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages such as low toxicity of the catalyst, low amount of the catalyst used, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor (no need of any post-treatments for a molded article), and the like.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: November 5, 2013
    Assignee: Kyoto University
    Inventors: Atsushi Goto, Yoshinobu Tsujii, Takeshi Fukuda
  • Publication number: 20130281743
    Abstract: Methods are provided for removing impurities from compositions comprising alkyl bromide. Such methods comprise combining such composition with at least one nonvolatile epoxide during distillation to purify the alkyl bromide. Ultra pure alkyl bromide compositions are also provided.
    Type: Application
    Filed: June 7, 2013
    Publication date: October 24, 2013
    Applicant: Albemarle Corporation
    Inventors: Willam B. Harrod, Dru J. Manuel, Keith G. Anderson, Aaron C. Williams, Kimberly A. Maxwell
  • Publication number: 20130165658
    Abstract: This invention is directed to a process for the preparation of high yield alkyl or aryl iodide from its corresponding carboxylic acid using N-iodo amides.
    Type: Application
    Filed: June 9, 2011
    Publication date: June 27, 2013
    Inventors: Gennady Nisnevich, Mark Gandelman, Kseniya Kulbitski
  • Publication number: 20120330001
    Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
    Type: Application
    Filed: May 22, 2012
    Publication date: December 27, 2012
    Applicant: PROMEGA CORPORATION
    Inventors: Aldis Darzins, Lance Encell, Tonny Johnson, Dieter Klaubert, Georgyi V. Los, Mark McDougall, Keith V. Wood, Monika G. Wood, Chad Zimprich
  • Patent number: 8188324
    Abstract: A process for the preparation of 11C methyl iodide comprises coating the internal surface of a first reaction vessel with a solution of lithium aluminum hydride, wherein the first reaction vessel has an internal diameter not greater than about 1.5 mm; introducing 11C carbon dioxide into the first reaction vessel such that it is reduced by the lithium aluminum hydride to give a reduction product; and reacting the reduction product with hydriodic acid.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: May 29, 2012
    Assignee: Hammersmith Imanet Limited
    Inventor: David Robert Turton
  • Patent number: 8143463
    Abstract: A process for the preparation of delmopinol (3-(4-propylheptyl)-4-morpholinethanol) or a derivative or a pharmaceutically acceptable salt, or a solvate thereof, including a hydrate, comprises reacting oxazolidin [2,3-c]morpholine and a Grignard reagent, and optionally converting the delmopinol (or derivative) free base into a pharmaceutically acceptable salt. The oxazolidin [2,3-c]morpholine and the Grignard reagent are useful as intermediates in the production process.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: March 27, 2012
    Assignee: Sinclair Pharmaceuticals Limited
    Inventors: Juan Jose Artus Surroca, David Fernandez Bleda, Tommaso Iacoangeli, Jordi Lluis Tous
  • Patent number: 8058489
    Abstract: A process is disclosed for making CF3CF?CHF or mixtures thereof with CF2?CFCHF2.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: November 15, 2011
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Velliyur Nott Mallikarjuna Rao, Allen Capron Sievert
  • Publication number: 20110275775
    Abstract: Provided is a catalyst used for a living radical polymerization method, which contains a central element consisting of carbon and at least one halogen atom binding to the central element. Further, a hydrocarbon compound can be used as a catalyst precursor. A monomer having a radical-reactive unsaturated bond is subjected to a radical polymerization reaction in the presence of the catalyst, consequently a polymer having narrow molecular weight distribution can be obtained, and thus the cost of the living radical polymerization can be remarkably reduced. The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages such as low toxicity of the catalyst, low amount of the catalyst used, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor (no need of any post-treatments for a molded article), and the like.
    Type: Application
    Filed: September 8, 2009
    Publication date: November 10, 2011
    Applicant: Kyoto University
    Inventors: Atsushi Goto, Yoshinobu Tsujii, Takeshi Fukuda
  • Patent number: 8049042
    Abstract: To provide a resist polymer comprising, as a structural unit, an acid-decomposable unit having a structure represented by formula (1) or (2) which exhibits a small line edge roughness and produces little defects in DUV excimer laser lithography or the like.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: November 1, 2011
    Assignee: Mitsubishi Rayon Co., Ltd.
    Inventors: Hikaru Momose, Atsushi Ootake, Tadashi Nakamura, Akifumi Ueda
  • Patent number: 8049047
    Abstract: Process for the manufacture of 1,2-dichloroethane (DCE) starting with a hydrocarbon source which is subjected to a cracking thus producing a mixture of cracking products then subjected to treatment steps to obtain a mixture of products containing ethylene. The mixture is afterwards subjected to a first separation step into a fraction enriched with the compounds that are lighter than ethylene containing some of the ethylene conveyed to a chlorination reactor in which most of the ethylene is converted to DCE, and into a fraction F1 which is subjected to a second separation step into a fraction F2 and into a heavy fraction. Fraction F2 is afterwards subjected to a third separation step into a fraction enriched with ethylene conveyed to an oxychlorination reactor in which most of the ethylene is converted to DCE, and into a fraction F3 mainly composed of ethane.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: November 1, 2011
    Assignee: Solvay (Societé Anonyme)
    Inventors: Dominique Balthasart, Michel Lempereur, Michel Strebelle
  • Patent number: 7982072
    Abstract: Process for the obtention of HFC-227ea having a reduced content of organic impurities, comprising at least subjecting a crude HFC-227ea to two distillation steps at different pressures.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: July 19, 2011
    Assignee: Solvay S.A.
    Inventors: Thomas Müller, Dominique Balthasart, Bernd Kutzner
  • Publication number: 20110092751
    Abstract: A process for the preparation of delmopinol (3-(4-propylheptyl)-4-morpholinethanol) or a derivative or a pharmaceutically acceptable salt, or a solvate thereof, including a hydrate, comprises reacting oxazolidin [2,3-c]morpholine and a Grignard reagent, and optionally converting the delmopinol (or derivative) free base into a pharmaceutically acceptable salt. The oxazolidin [2,3-c]morpholine and the Grignard reagent are useful as intermediates in the production process.
    Type: Application
    Filed: December 20, 2010
    Publication date: April 21, 2011
    Inventors: Juan Jose ARTUS SURROCA, David Fernandez Bleda, Tommaso Iacoangeli, Jordi Lluis Tous
  • Publication number: 20110082301
    Abstract: It comprises a process for the production of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by subjecting the compound of formula (II) where R1 and R2 are the same or different, independently selected from the group consisting of H, (C1-C6) alkyl or, alternatively, R1 and R2 form, together with the carbon atom to which they are attached, a (C5-C6) cycloalkyl radical; and R3 is a radical selected from the group consisting of CF3, (C1-C4) alkyl, phenyl, and phenyl mono- or disubstituted by a radical selected from the group consisting of (C1-C4)-alkyl, halogen and nitro to a deprotection and cyclisation reaction. The process is useful to prepare delmopinol or its salts on an industrial scale. The compound of formula (II) is new and also forms part of the present invention, as well as its preparation process and other new intermediates of said preparation process.
    Type: Application
    Filed: December 20, 2010
    Publication date: April 7, 2011
    Inventors: Alexander Comely, Llorenç Rafecas Jane, Nicolas Tesson, Antoni Riera Escale
  • Publication number: 20110071263
    Abstract: Process for the manufacture of at least one ethylene derivative compound starting with a hydrocarbon source according to which: a) the hydrocarbon source is subjected to a simplified cracking which produces a mixture of products containing ethylene and other constituents; b) the mixture of products is fractionated in one fractionation step into one fraction containing almost all the ethylene (fraction A), optionally into one individual fraction of ethane and into one heavy fraction (fraction C); and c) the fraction A is conveyed to the manufacture of at least one ethylene derivative compound.
    Type: Application
    Filed: May 29, 2009
    Publication date: March 24, 2011
    Applicant: SOLVAY (SOCIETE ANONYME)
    Inventors: Michel Lempereur, Dominique Balthasart, Michel Strebelle, Joachim Kotter, Hans-Dieter Winkler, Peter Mews
  • Patent number: 7816569
    Abstract: The invention relates to a process for the preparation of chloromethane from methanol and hydrogen chloride contaminated with Si compounds, the Si compounds being methylchlorosilanes, methoxymethylsilanes and hydrolysis and condensation products thereof, in which some of the Si compounds are removed by condensation from the chloromethane formed and remaining Si compounds are washed out with methanol, the methanol thus obtained and containing Si compounds being used for the further preparation of chloromethane with hydrogen chloride.
    Type: Grant
    Filed: May 13, 2008
    Date of Patent: October 19, 2010
    Assignee: Wacker Chemie AG
    Inventors: Klaus Kaeppler, Gerhard Nagy
  • Patent number: 7667083
    Abstract: A compound containing two fluorosulfonyl groups which are groups convertible to sulfonic acid groups, an intermediate therefor, and methods for their production with high productivity, are provided. Also provided are a fluorosulfonyl group-containing polymer obtained by polymerizing such a compound, and a sulfonic acid group-containing polymer obtained from such a polymer. A method for producing a compound of the following formula (m0), such a compound, a fluorosulfonyl group-containing polymer obtained by polymerizing such a compound, and a sulfonic acid group-containing polymer obtained from such a polymer, provided that RF01 is a single bond or a C1-6 bivalent perfluoro organic group, RF02 is a C1-6 bivalent perfluoro organic group, and n is 0 or 1.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: February 23, 2010
    Assignee: Asahi Glass Company, Limited
    Inventors: Isamu Kaneko, Atsushi Watakabe, Jyunichi Tayanagi, Susumu Saito
  • Publication number: 20090267022
    Abstract: Halocarbons of the structure CF3CF2CH2X, wherein X is either F or Cl or mixtures thereof prepared by: contacting at least one 2-fluorochloropropane with hydrogen fluoride in a first fluorination step in the gas phase or liquid phase under substantially anhydrous conditions, in the absence of added catalyst to partially fluorinate said 2-fluorochloropropane; contacting said partially fluorinated 2-fluorochloropropane with at least the stoichiometric molar equivalent of hydrogen fluoride under substantially anhydrous conditions, in the presence of at least one fluorination catalyst in a second fluorination step; removing said reaction products from contact with said catalyst, and isolating a substantial yield of at least 1,1,1,2,2,3-hexafluoropropane or 1,1,1,2,2,penta-3-chloropropane, or mixtures thereof, respectively.
    Type: Application
    Filed: September 5, 2007
    Publication date: October 29, 2009
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Mario Joseph Nappa, Velliyur Nott Mallikarjuna Rao, Allen Capron Sievert, Jeffery P. Knapp
  • Publication number: 20090266995
    Abstract: The present invention provides methods and compositions for modulating x-ray attenuation, where the x-ray attenuation compound can comprise a molecule having at least two conformational states, a first k-edge atom attached to the molecule at a first position, and a second k-edge atom attached to the molecule at a second position, where the molecule changes from a first conformational state to a second conformational state in response to an external stimulus. Additionally, a first interatom distance between the first k-edge atom and the second k-edge atom in the first conformational state can be within a first harmonic error of 0 to about 0.2, and a second interatom distance between the first k-edge atom and the second k-edge atom in the second conformational state can be within a second harmonic error of about 0.8 to 1.0.
    Type: Application
    Filed: April 14, 2009
    Publication date: October 29, 2009
    Inventors: Steven Poelzing, Rengasayee Veeraraghavan, Adam Smoot
  • Publication number: 20090036677
    Abstract: It comprises a preparation process of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by submitting the compound of formula (II) where R1 and R2 are the same or different, independently selected from the group consisting of H, (C1-C6)-alkyl or, alternatively, R1 and R2 form, together with the carbon atom to which they are attached, a (C5-C6)-cycloalkyl radical; and R3 is a radical selected from the group consisting of CF3, (C1-C4)-alkyl, phenyl, and phenyl mono- or disubstituted by a radical selected from the group consisting of (C1-C4)-alkyl, halogen and nitro to a deprotection and cyclisation reaction. The process is useful to prepare delmopinol or its salts on an industrial scale. The compound of formula (II) is new and also forms part of the present invention, as well as its preparation process and other new intermediates of said preparation process.
    Type: Application
    Filed: January 10, 2007
    Publication date: February 5, 2009
    Inventors: Alexander Comely, Llorenc Rafecas Jane, Nicolas Tesson, Atoni Riera Escale
  • Publication number: 20080300433
    Abstract: [Object] To stabilize normal propyl bromide by using a novel stabilizer which is friendly to the environment. [Solving Means] A composition includes, relative to 100 parts by weight of normal propyl bromide, 0.1 parts by weight to 10 parts by weight of at least one stabilizer selected from the following (A) to (D): (A) 3,4-epoxycyclohexenylmethyl 3?,4?-epoxycyclohexene carboxylate; (B) ?-caprolactone modified 3,4-epoxycyclohexylmethyl 3?,4?-epoxycyclohexane carboxylate; (C) vinylcyclohexene monoxide; and (D) 1,2:8,9-diepoxylimonene.
    Type: Application
    Filed: August 29, 2006
    Publication date: December 4, 2008
    Applicant: Kaneko Chemical Co., Ltd.
    Inventor: Akiyasu Kaneko
  • Publication number: 20080287716
    Abstract: The invention relates to a process for the preparation of chloromethane from methanol and hydrogen chloride contaminated with Si compounds, the Si compounds being methylchlorosilanes, methoxymethylsilanes and hydrolysis and condensation products thereof, in which some of the Si compounds are removed by condensation from the chloromethane formed and remaining Si compounds are washed out with methanol, the methanol thus obtained and containing Si compounds being used for the further preparation of chloromethane with hydrogen chloride.
    Type: Application
    Filed: May 13, 2008
    Publication date: November 20, 2008
    Applicant: WACKER CHEMIE AG
    Inventors: Klaus Kaeppler, Gerhard Nagy
  • Publication number: 20080207909
    Abstract: A process for the preparation of 11C methyl iodide comprises coating the internal surface of a first reaction vessel with a solution of lithium aluminium hydride, wherein the first reaction vessel has an internal diameter not greater than about 1.5 mm; introducing 11C carbon dioxide into the first reaction vessel such that it is reduced by the lithium aluminium hydride to give a reduction product; and reacting the reduction product with hydriodic acid.
    Type: Application
    Filed: March 23, 2006
    Publication date: August 28, 2008
    Inventor: David Robert Turton
  • Patent number: 7323608
    Abstract: One aspect of the present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-sulfur bond between the sulfur atom of a thiol moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper(II)-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-carbon bond between the carbon atom of cyanide ion and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: January 29, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen L. Buchwald, Artis Klapars, Fuk Y. Kwong, Eric R. Streiter, Jacopo Zanon
  • Patent number: 7060862
    Abstract: A method of synthesizing a high purity product of ?,?,??,??-tetrachloro-p-xylene is disclosed. The method includes carrying out a first stage reaction of terephthaldicarboxaldehyde with a mixture of SOCl2 and dimethylformamide (DMF) to obtain a product mixture containing ?,?,??,??-tetrachloro-p-xylene as a major product and 4-dichloromethyl benzaldehyde as a side product; adding SOCl2 and DMF to the product mixture of the first stage reaction to undergo a second stage reaction; and to a cool water adding the resulting product mixture from the second stage reaction to obtain a solid product of ?,?,??,??-tetrachloro-p-xylene with a purity of 90-99 mol %.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: June 13, 2006
    Assignee: Chung-Shan Institute of Science & Technology
    Inventors: Shean-Jeng Jong, Chun-Hsu Lin, Chao-chou Tu, Chung-Chien Chang
  • Patent number: 6992231
    Abstract: A synthesis method of ?,?,??,??-tetrachloro-p-xylene is disclosed. The method includes reacting terephthaldicarboxaldehyde with a mixture of SOCl2 and dimethylformamide (DMF) to obtain a product mixture containing ?,?,??,??-tetrachloro-p-xylene as a major product and 4-dichloromethyl benzaldehyde as a side product, which can be separated by silica column chromatography.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: January 31, 2006
    Assignee: Chung-Shan Institute of Science & Technology
    Inventors: Shean-Jeng Jong, Chun-Hsu Lin, Ming-Te Shih, Chung-Chien Chang
  • Patent number: 6881872
    Abstract: Less colored trans-1,3-dichloropropene and a process for producing it, are presented. A composition comprising cis-1,3-dichloropropene, trans-1,3-dichloropropene and C6 compounds, is subjected to a distillation step and to a step of reacting chlorine or bromine, to remove cis-1,3-dichloropropene as a low boiling component, and then the residue is distilled to remove the chlorinated C6 compounds as a high boiling component and to obtain trans-1,3-dichloropropene as a low boiling component.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: April 19, 2005
    Assignee: Asahi Glass Company, Limited
    Inventors: Tomoko Matsumoto, Tateo Nakano, Yutaka Yokoyama
  • Patent number: 6844474
    Abstract: The present invention provides a vapor phase process for the production of difluoromethane, HFC-32. The process of this invention provides for the preparation of HFC-32 by a process that exhibits both good product yield and selectivity.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: January 18, 2005
    Assignee: Allied Signal Inc.
    Inventors: Paul Gene Clemmer, Addison Miles Smith, Hsueh Sung Tung, John Stephen Bass
  • Publication number: 20040244641
    Abstract: An active ray curable ink-jet ink composition comprising a photo-induced acid generating agent containing an onium salt which does not generate benzene under active ray radiation, and a photopolymerizable compound containing a compound having an oxetane ring in the molecule.
    Type: Application
    Filed: April 15, 2004
    Publication date: December 9, 2004
    Applicant: KONICA MINOLTA MEDICAL & GRAPHIC, INC.
    Inventors: Toshiyuki Takabayashi, Norio Miura, Masato Nishizeki, Kimihiko Okubo
  • Patent number: 6743825
    Abstract: An additive mixture useful as a flame retardant is described. The mixture is comprised of (i) a poly(bromophenyl)alkane having in the molecule in the range of 13 to 60 carbon atoms and in the range of two to four aryl groups and (ii) a poly(bromophenyl)bromoalkane having in the molecule in the range of 13 to 60 carbon atoms and in the range of two to four aryl groups, said poly(bromophenyl)bromoalkane being in an amount which is greater than 25 wt %, based on the total weight of the additive mixture. A facile process for making the poly(bromophenyl)bromoalkane is also described.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: June 1, 2004
    Assignee: Albemarle Corporation
    Inventors: Raymond B. Dawson, Saadat Hussain
  • Patent number: 6627777
    Abstract: Catalysts for the fluid-bed hydrodechlorination of carbon tetrachloride to chloroform having high catalytic stability and comprising platinum supported on microspheroidal gamma alumina, characterized in that the platinum is in the form of particles dispersed throughout the mass of the support.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: September 30, 2003
    Assignee: Sud Chemie MT S.R.L.
    Inventors: Michele Rossi, Carlo Rubini, Antonio Pasquale, Luigi Cavalli
  • Patent number: 6548705
    Abstract: Disclosed is a compound comprising a saturated oligomer of isoprene bonded to a polar group, said compound having formula (I): in which R is H or a C1-C4 alkyl, n is 2-17, and R′ is a radical selected from the group consisting of X, COOR″, CN, NR2, and NR2.HX, wherein R″ is selected from the group consisting of R, NR2, and NR2.HX or a monovalent metal cation, X being I, Cl, Br or F, and each R in NR2 and NR2.HX being the same or different. In a preferred embodiment the polar group is a quaternary ammonium radical. The compound is useful as a compatibilizer of solid inorganic material, and propylene and ethylene polymer material.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: April 15, 2003
    Assignee: Basell Poliolefine Italia S.p.A.
    Inventors: C. Edward Bishop, Suhas G. Niyogi
  • Patent number: 6489524
    Abstract: Aromatic substrates are Ar-brominated in high yield and selectivity by reacting the substrate with a brominating agent in the presence of at least about 0.19 gram per mmol of substrate of a zeolite catalyst which has an absorbed water content of no greater than about 7.5 weight percent.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: December 3, 2002
    Assignee: Albemarle Corporation
    Inventors: Mahmood Sabahi, Hassan Y. Elnagar, Robert L. Davis
  • Publication number: 20020128527
    Abstract: The invention concerns semi-fluorinated alkanes of the general formulae RFRH or RFRHRF, RF being a linear or branched perfluoroalkyl group and RH being a linear or branched saturated (hydrocarbon)-alkyl group.
    Type: Application
    Filed: May 15, 2001
    Publication date: September 12, 2002
    Inventor: Hasso Meinert
  • Patent number: 6403789
    Abstract: A halogenating agent of the formula (1) and a method of halogenating hydroxyl group wherein R1 and R2 are the same or different and are each ethyl, propyl, isopropyl, butyl, isobutyl or allyl; X is chlorine atom or bromine atom; and Y is chlorine ion, bromine ion, dichlorophosphate ion, dibromophosphate ion, chlorosulfonate ion, bromosulfonate ion, chlorooxalate ion or bromooxalate ion.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: June 11, 2002
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventors: Daisuke Suzuki, Ryo Kikuchi, Masaru Yasui
  • Publication number: 20020015826
    Abstract: Photoresist compositions, or photoacids, are used in etching circuit pathways on the surface of microelectronic components. Iodonium compounds generate a strong acid under short wavelength irradiation, which is capable of etching the polymeric surface coating of a silicon wafer. The strong acid is the conjugate acid of the counteranion. Larger counterions generate acids that diffuse to a lesser extent in the polymer resist matrix, producing better image resolution. Given the particular anion, the solubility of its diary iodonium salts will depend upon which aromatic rings are used on the iodonium molecule. A zwitterionic structure of the iodonium molecule, having both positive and negative charges on the same molecular species, can be used as photoacid composition in the photoresist step of microchip manufacturing.
    Type: Application
    Filed: April 10, 2001
    Publication date: February 7, 2002
    Inventors: Darryl Desmarteau, Vitorio Montanari, Brian H. Thomas
  • Patent number: 6255544
    Abstract: A liquid phase process is disclosed for producing halogenated alkane adducts of the formula CAR1R2CBR3R4 (where A, B, R1, R2, R3, and R4 are as defined in the specification) which involves contacting a corresponding halogenated alkane, AB, with a corresponding olefin, CR1R2═CR3R4 in a solvent and in the presence of a catalyst system containing (i) at least one catalyst comprising monovalent copper, and (ii) at least one ionic promoter selected from the group consisting of substituted ammonium halides, pyridinium and substituted pyridinium halides, and quaternary salts of the type (MQ4)Y where M is an element of Group VA of the Periodic Table (i.e., N, P, As, Sb, or Bi), Q is a C1-C18 hydrocarbyl group, and Y is chloride, bromide or iodide. Production of hydrofluoroalkanes by reacting selected adducts of the type produced above with HF is also disclosed.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: July 3, 2001
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Allen Capron Sievert
  • Patent number: 6194567
    Abstract: A halogenating agent of the formula (1) and a method of halogenating hydroxyl group wherein R1 and R2 are the same or different and are each ethyl, propyl, isopropyl, butyl, isobutyl or allyl; X is chlorine atom or bromine atom; and Y is chlorine ion, bromine ion, dichlorophosphate ion, dibromophosphate ion, chlorosulfonate ion, bromosulfonate ion, chlorooxalate ion or bromooxalate ion.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: February 27, 2001
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventors: Daisuke Suzuki, Ryo Kikuchi, Masaru Yasui
  • Patent number: 5955637
    Abstract: A process for producing difluoromethane is disclosed which includes the step of contacting a gaseous mixture containing CH.sub.2 Cl.sub.2 and hydrogen fluoride with a catalyst containing a catalytically effective amount of trivalent chromium supported on a carbon having an ash content of less than 0.5 percent by weight, at a temperature of from about 180.degree. C. to about 375.degree. C. The catalyst and temperature conditions of this process allow the concurrent reaction CCl.sub.3 CF.sub.3 with HF to form CCl.sub.2 FCF.sub.3. CH.sub.2 ClF and unreacted CH.sub.2 Cl.sub.2, each of which may be recovered as an azeotrope with HF, may be recycled.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: September 21, 1999
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Paul S. Furmanek, David A. Glasscock, Michael Keane, Jr.