Radio Frequency Wave Induced Magnetic Field For Subcutaneous Hyperthermia Patents (Class 600/10)
  • Patent number: 11123478
    Abstract: A fecal collection device includes a barrel with a waste drain conduit attached thereto. A drain opening is defined between passages of the barrel and the waste drain conduit. An irrigation conduit is connected to a source of lavage liquid. A trocar plug has a tapered distal end and moves between insertion, irrigation and flushing positions within the barrel passage. When in the insertion position, the tapered distal end of the trocar plug extends from the distal end of the barrel. When in the irrigation position, the irrigation conduit may provide lavage liquid to the barrel passage while the trocar plug covers a majority of the drain opening. When in a flushing position, the trocar plug covers less of the drain opening than when the trocar plug is in the irrigation position.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 21, 2021
    Assignee: Hollister Incorporated
    Inventors: Jerome A Henry, Malford E Cullum
  • Patent number: 10661093
    Abstract: Systems and methods for increasing skin rejuvenation of a region of a patient's skin. The system includes: a pulsed electromagnetic field (PEMF) frequency generator that emits electromagnetic pulses to the region of the patient's skin; and a deep tissue diathermy device that applies heat to the region of the patient's skin up to temperature T. The system simultaneously applies the heat and the PEMF to the region of a patient's skin.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: May 26, 2020
    Assignee: VENUS CONCEPT LTD
    Inventors: Oded Ron Edoute, Orit Ron Edoute, Itzhak Kremin, Vadim Polyakov
  • Patent number: 10398505
    Abstract: The invention relates to a thermal treatment applicator (19) for the deposition of thermal energy within tissue of a body (10) of a patient. The applicator (19), comprises: a plurality of RF antennae (20) for radiating a RF electromagnetic field toward the body (10); —a plurality of RF power amplifiers (21) supplying RF signals to the RF antennae (20), wherein each RF power amplifier (21) comprises a transistor and an output matching network (22) transforming the output impedance of the transistor into a low impedance value. Moreover, the invention relates to a MR imaging guided therapy system (1).
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: September 3, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Christoph Leussler
  • Patent number: 9867974
    Abstract: A device is provided for the administration of a compound in a body. The device includes a capsule having a reservoir therein for receiving the compound therein and a delivery instrument for positioning the capsule within the body. The delivery instrument includes a barrel having an interior adapted to receive the capsule therein and a dispersal element interacting with the barrel to selectively expel the capsule therefrom and into the body. A diffusion regulator communicates with the reservoir and controls the diffusion of the compound from the reservoir into the body. A retention structure projects from capsule and is configured to retain the capsule at a desired location within the body. Multiple devices may be used in conjunction to provide a multiplexed point source to administer multiple compounds simultaneously in vivo.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: January 16, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Mark E. Burkard, Jay W. Warrick, David J Guckenberger, Lee G. Wilke
  • Patent number: 9814897
    Abstract: Systems and methods for increasing skin rejuvenation of a region of a patient's skin. The system includes: a pulsed electromagnetic field (PEMF) frequency generator that emits electromagnetic pulses to the region of the patient's skin; and a deep tissue diathermy device that applies heat to the region of the patient's skin up to temperature T. The system simultaneously applies the heat and the PEMF to the region of a patient's skin.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: November 14, 2017
    Assignee: VENUS CONCEPT LTD.
    Inventors: Oded Ron Edoute, Orit Ron Edoute, Itzhak Kremin, Vadim Polyakov
  • Patent number: 9492679
    Abstract: Described herein are methods for modulating the susceptibility of one or more target or tissue regions, and particularly one or more brain regions, to a therapeutic agent such as a drug, immune agent, compound, radiation, etc. In particular, the methods and systems described herein may include magnetic stimulation (including transcranial magnetic stimulation) of target or non-target regions to modulate the susceptibility of the one or more target or tissue regions to a therapeutic agent.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: November 15, 2016
    Assignee: Rio Grande Neurosciences, Inc.
    Inventors: M. Bret Schneider, Michael J. Partsch
  • Patent number: 9162076
    Abstract: Disclosed herein is an apparatus for tissue regeneration or degeneration in human by applying rotational field narrow focused quantum magnetic resonance on the required area. The apparatus consists of a plurality of guns for delivery the quantum magnetic resonance, a traveling platform for carrying the person under treatment, an electronic switching system for controlling the guns, said electronic switching system being controlled by a main computer through an on board microprocessor and means for cooling and dispersing the heat generated during the operation.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: October 20, 2015
    Inventor: Rajah Vijay Kumar
  • Patent number: 9011310
    Abstract: Effective systems and methods for improving neural communication impairment of a vertebrate being and affecting motor activity of a peripheral body part including a first signal-providing component configured to provide pulsed peripheral stimulation signals at the peripheral body part, a second signal-providing component configured to provide a pulsed motor cortex stimulation signal to a motor cortex area, a substantially DC signal-providing component configured to provide direct current spinal stimulation signal at a neural spinal junction and a controller component configured to control timing of the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: April 21, 2015
    Assignee: The Research Foundation of the City University of New York
    Inventor: Zaghloul Ahmed
  • Patent number: 8882762
    Abstract: A transmural ablation device is provided to achieve endocardial and epicardial ablation at the same site but directed from the inner and outer surfaces of the heart to create a transmural lesion. By ablating from both sides of the heart tissue, it is possible to increase the depth of the lesion created and to increase the likelihood of a transmural lesion. Embodiments pertain to techniques to align the endocardial and epicardial ablation elements and techniques to position and move the endocardial and epicardial ablation elements along a predefined linear, curvilinear, or circular path. The ability to bring the epicardial and endocardial elements more closely or firmly with the underlying tissue is important in creating optimal lesions. Magnetic force attracts the epicardial and endocardial elements.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: November 11, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Paul J Wang, Amin Al-Ahmad, William Francis Johnston, Kai Ihnken, Kaartiga Sivanesan, Morgan Clyburn, Kathleen Lee Kang, Lauren Shui Sum Chan, Robert C Robbins, Friedrich B. Prinz
  • Patent number: 8840536
    Abstract: Systems, devices, and methods are described for providing a monitor/treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: September 23, 2014
    Inventors: Michael C. Hegg, Matthew P. Horning, Jordin T. Kare, Nathan P. Myhrvold, Clarence T. Tegreene, Benjamin K. Wilson, Lowell L. Wood, Jr.
  • Publication number: 20140249351
    Abstract: A microparticle composition(s) comprising nanomagnetic particles and a matrix, wherein said microparticle composition(s) have a least one of the following properties: (a) a VAR of at least about 1 Watts/cm3 subject to appropriate field conditions; (b) a density of about 2.7 or less: or (c) a size of about 100 nm to about 200 microns.
    Type: Application
    Filed: May 15, 2014
    Publication date: September 4, 2014
    Applicant: Sirtex Medical Limited
    Inventors: Stephen Keith Jones, Katrina Francis Rutherford, Andrew John Ruys, Bruce Nathaniel Gray
  • Publication number: 20140155733
    Abstract: A method and composition for hyperthermally treating tumor cells in a patient under conditions that affect tumor stem cells and tumor cells. In one embodiment, the method is administered in combination with localized internal ionizing radiation therapy.
    Type: Application
    Filed: June 11, 2013
    Publication date: June 5, 2014
    Inventor: Gholam A. Peyman
  • Patent number: 8734316
    Abstract: This invention relates to an apparatus that regulates thermodynamic energy-flow within a human body for producing beneficial effects such as, for example, improvement in strength, improvement in stamina, pain relief, etc. According to one embodiment, the invention provides a wearable apparatus that may include biomolecular components for building-up of a thermomagnetic energy within the human body. According to another embodiment, the invention provides a wearable apparatus that may include biomolecular components for dilution of a thermomagnetic energy within the human body. According to yet another embodiment, the invention provides a wearable apparatus that may include biomolecular components having orthomolecular and/or non-orthomolecular organic materials which are capable of thermomagnetic levororotary action and/or thermomagnetic dextrorotatory action.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: May 27, 2014
    Assignee: LifeWave, Inc.
    Inventor: David Schmidt
  • Patent number: 8688229
    Abstract: The invention relates to an alternating magnetic field application device for heating magnetic or magnetizable substances in biological tissue, in particular for thermal therapy using magnetic nanoparticles, composed of a large applicator (1) having a magnetic yoke (2) and two oppositely situated pole shoes (7, 8) on the magnetic yoke (2) which are separated by an exposure gap (13), and having two magnetic coils (9, 10), which are respectively associated with a pole shoe (7, 8), for generating a substantially homogenous alternating magnetic field (12) of a given field strength in the exposure gap (13), wherein the biological tissue to be irradiated may be brought into the exposure gap (13) as an exposure target volume.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: April 1, 2014
    Assignee: Magforce AG
    Inventors: Peter Feucht, Volker Brüss, Andreas Jordan
  • Publication number: 20140081069
    Abstract: A deep magnetic field generating apparatus includes a first coil unit and a second coil unit. The second coil unit is connected with the first coil unit, and disposed around the first coil unit horizontally. Accordingly, the deep magnetic field generating apparatus can generate a desired deep magnetic field.
    Type: Application
    Filed: February 12, 2013
    Publication date: March 20, 2014
    Applicants: METAL INDUSTRIES RESEARCH & DEVELOPMENT CENTRE, NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Cheng-Chi TAI, Shyh-Jier HUANG, Xi-Zhang LIN, Chien-Chang CHEN, Tsung-Chih YU
  • Patent number: 8672826
    Abstract: The present invention relates to the in vivo stimulation of cellular material. In particular, the present invention relates to a method for stimulating cells and tissue in vivo comprising the step of applying to said cells and tissue an electrobiomimetic stimulus, wherein the growth characteristics of said cells and tissue are enhanced as compared to cells and tissue not receiving said stimulus.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: March 18, 2014
    Assignee: Global Energy Medicine Pty. Ltd.
    Inventors: Jeffrey David Edwards, Chin Joo Goh, Kay Fei Chan
  • Patent number: 8652023
    Abstract: An electrical system having an underlying structure resembling the double helix most commonly associated with DNA is used to produce useful electromagnetic fields for health applications and/or medical applications.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: February 18, 2014
    Assignee: LifeWave, Inc.
    Inventor: David G. Schmidt
  • Publication number: 20140012063
    Abstract: The accuracy of tissue heating in a body when using a phased array hyperthermia system can be improved by using, in conjunction with the hyperthermia system, a program for predicting heating patterns within the tissue based upon a selected E-field value at each of the antenna energy feedpoints. The hyperthermia system includes circuitry necessary to provide information for calculating the complete EM field at each of the antenna feedpoints during treatment, and such calculated actual feedpoint EM fields are feed to the program to be used in place of the otherwise program generated e-fields in predicting the heating pattern produced by the hyperthermia system during treatment. Further initial operating parameters of the hyperthermia system can be set to produce calculated actual EM fields at the antenna feedpoints which approximate the E-field values used by the program in pretreatment optimizing of the heating pattern.
    Type: Application
    Filed: July 6, 2012
    Publication date: January 9, 2014
    Inventors: Paul F. Turner, Mark Hagmann
  • Patent number: 8567410
    Abstract: The present invention relates to aerosols containing magnetic particles, wherein the aerosols comprise magnetic particles and a pharmaceutical active agent. The invention furthermore relates to the use of such aerosols containing magnetic particles for directed magnetic field-guided transfer of the active agents contained therein in aerosol therapy.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: October 29, 2013
    Assignee: Ethris GmbH
    Inventors: Carsten Rudolph, Joseph Rosenecker
  • Publication number: 20130237742
    Abstract: The invention concerns a system for producing. specific field distributions in a defined volume or region. The system comprises an array of electromagnetic field generating elements each with an integrated sensor for measuring the phase and amplitude of the current flowing in a metallic element (antenna or coil) or field in a slot based element, a measurement device to enable measurement of both phase and amplitude of the electrical signals from the sensors with sufficient dynamic range for quantification of the signal, a multi channel radio frequency power source with individually controllable amplitude and phase to excite each of the electromagnetic field generating elements, and a feedback controller enabling controlled adjustment of the amplitude and phase of the radio frequency power source based on the signals from the sensors.
    Type: Application
    Filed: September 6, 2011
    Publication date: September 12, 2013
    Inventors: Myles Capstick, Niels Kuster, Sven Kuehn, Esra Neufeld
  • Patent number: 8527063
    Abstract: A system to induce hyperthermia in a selected portion of the body utilizes permanent magnets mounted on a variable speed motor. A conductive button is positioned at a location proximate the target tissue to be heated, such as a tumor. The magnetic rotor assembly is positioned at a selected distance from the conductive button and rotated at a desired frequency to produce a changing permanent magnetic field that induces an eddy current on the surface of the conductive button. A temperature sensor may be positioned near the conductive button as a feedback mechanism to a control circuit. At higher magnetic polarity frequencies, the conductive button may be implemented in the form of metallic nanoparticles. In this embodiment, the nanoparticles may include molecular elements that selectively bind with the target tissue and thereby accumulate at the target tissue prior to the introduction of the rotating magnetic field.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: September 3, 2013
    Inventor: Karl J. Lamb
  • Publication number: 20130204068
    Abstract: A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension.
    Type: Application
    Filed: December 14, 2012
    Publication date: August 8, 2013
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: The Board of Trustees of the Leland Stanford Junior University
  • Patent number: 8488856
    Abstract: A magnetic resonance imaging apparatus includes a cine-imaging unit, a characterizing-part detecting unit, a motion-analyzing unit, and an image-extracting unit. First, the cine-imaging unit collects the time-series images of a region of interest in a subject and reconstructs an image. Next, the characterizing-part detecting unit detects the characteristics of the time-series images. The motion-analyzing unit analyzes motion-characteristic values of the characteristics extracted by the characterizing-part detecting unit. The image-extracting unit extracts a specified time-series image in accordance with the motion-characteristic values.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: July 16, 2013
    Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventor: Masao Yui
  • Publication number: 20130178691
    Abstract: A dental floss apparatus comprised of a pair of handles that are configured for engagement with the fingers with strands of flossing substrate extending therebetween. The flossing substrates are spaced from each other, running substantially parallel and extending within an opening formed between the ends of the handles. A dissolvable substrate is positioned within this opening through an engagement with one or both of the handles or the flossing substrate, and upon contact with the surface of the teeth, dissolves, and deposits a residue on the surface of the teeth and the surrounding area of the mouth. The dissolvable substrate may be formed of two substrate pieces with a central gap between them defining a means for targeting insertion of the substrate between adjacent teeth and may be colorized or luminescent and have an additive material such as mouthwash, breath freshener, cooling agent, or flavor.
    Type: Application
    Filed: January 11, 2012
    Publication date: July 11, 2013
    Inventors: Petr Saha, Natalia Kazantseva, Petr Humpolicek, Robert Moucka, Jarmita Vilcakova, Pavel Valasek
  • Patent number: 8415123
    Abstract: An apparatus and method for electromagnetic treatment of living tissues and cells comprising: configuring at least one waveform according to a mathematical model having at least one waveform parameter, said at least one waveform to be coupled to a angiogenesis and neovascularization target pathway structure; choosing a value of said at least one waveform parameter so that said at least waveform is configured to be detectable in said angiogenesis and neovascularization target pathway structure above background activity in said target pathway structure; generating an electromagnetic signal from said configured at least one waveform; and coupling said electromagnetic signal to said angiogenesis and neovascularization target pathway structure using a coupling device.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: April 9, 2013
    Assignee: Ivivi Health Sciences, LLC
    Inventors: Arthur A. Pilla, Andre′ A. DiMino
  • Publication number: 20130053619
    Abstract: The Body Cavity Cancer Treatment System achieves extremely uniform temperatures inside the tissue of the body cavity thereby realizing optimal efficacy in enhancing operation of the chemotherapy agent while avoiding harm or pain to the patient. This is accomplished by the inclusion of “target particles”, such as nano-particles, into the body cavity along with the chemotherapy agent to enable the use of an externally generated energy field to cause heating of the chemotherapy agent and the surrounding tissue of the body cavity by the activation of the nano-particles. The proper selection of the applied energy field enables precise control of the heat generated by the movement of the nano-particles.
    Type: Application
    Filed: August 21, 2012
    Publication date: February 28, 2013
    Applicant: Actium BioSystems, LLC
    Inventors: Danie B. McKenna, Robert J. Tondu, Alireza Mashal, Karl M. Frantz, Martin A. Huisjen
  • Publication number: 20130053620
    Abstract: The Body Cavity Cancer Treatment Apparatus generates the magnetic field for use in a combined “Low Temperature Hyperthermia” and ionizing radiation and/or chemotherapy cancer treatment protocol. Unlike other competing systems, the Body Cavity Cancer Treatment Apparatus does not directly kill or ablate the cancer cells with killing temperatures rather, the Body Cavity Cancer Treatment Apparatus stresses the cancer and cancer stem cells by keeping them at a nominal 42° Celsius for some period of time via the heating of nano-particles that have been infused into the bladder, using the generated magnetic field.
    Type: Application
    Filed: August 21, 2012
    Publication date: February 28, 2013
    Applicant: Actium BioSystems, LLC
    Inventors: Michael Edward Susedik, Karl Michael Frantz, Daniel Bernard McKenna, Martin Albert Huisjen, Carolyn Perry Adams
  • Publication number: 20120308657
    Abstract: The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer's disease and related diseases and conditions.
    Type: Application
    Filed: November 1, 2010
    Publication date: December 6, 2012
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Vinayak P. Dravid, Saurabh Sharma, Tadanori Tomita, Kirsten L. Viola, William L. Klein
  • Publication number: 20120265000
    Abstract: An apparatus for exposing a region of interest of an object, animal or person to an alternating magnetic field has a source of radio-frequency electromagnetic radiation arranged to provide the alternating magnetic field in an exposure volume defined by the apparatus, and a shield arranged between the source of radio-frequency electromagnetic radiation and the exposure volume. The shield includes a material that has a sufficient thickness and arrangement to reduce power deposition to at least regions outside of the region of interest of the object, animal or person during exposure in the exposure volume.
    Type: Application
    Filed: October 22, 2010
    Publication date: October 18, 2012
    Applicant: The Johns Hopkins University
    Inventors: Robert Ivkov, Ananda Kumar
  • Patent number: 8265910
    Abstract: Methods and systems for modeling and displaying magnetic field intensities during Transcranial Magnetic Stimulation (TMS) are described, particularly methods and system for modeling and displaying TMS using overlapping magnetic fields to stimulate deep brain regions.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: September 11, 2012
    Assignee: Cervel Neurotech, Inc.
    Inventors: David J. Mishelevich, M. Bret Schneider
  • Publication number: 20120209053
    Abstract: An electromagnetic thermotherapeutic apparatus includes: a plurality of needle units respectively having head portions and needle portions; a base unit having a base plate that is formed with a plurality of first through holes, and a base pad that is formed with a plurality of second through holes, the needle portions of the needle units removably extending through the second and first through holes, the head portions of the needle units abutting against the base pad; a temperature monitor disposed between the base plate and the base pad; an upper unit disposed above the base pad and abutting against the head portions; and a clamp unit clamping and pressing the base unit against the upper unit.
    Type: Application
    Filed: January 26, 2012
    Publication date: August 16, 2012
    Applicant: National Cheng Kung University
    Inventors: Gwo-Bin Lee, Xi-Zhang Lin, Sheng-Chieh Huang, Yi-Yuan Chang, Yan-Shen Shan, Sheng-Jye Hwang, Tung-Jen Lee, Szu-Yin Chen, Ping-Hen Chen
  • Publication number: 20120190911
    Abstract: The Low Temperature Hyperthermia System illuminates nano-particles, which are implanted in a living organism at the locus of the cancer or into the cancer cells, with a precisely determined energy field. This energy field ensures that the optimal cancer cell and cancer stem cell destruction temperature of 42° C. is not exceeded in the tissue, which minimizes the release of Heat Shock Proteins and cancer stem cells. The Low Temperature Hyperthermia System uses specially designed nano-particles that exhibit a specific temperature rise in a given illumination energy field and then have no further temperature rise even if the applied illumination energy field increases beyond the optimal level. Alternatively, the nano-particles exhibit a tightly controlled temperature rise based on a pre-determined illumination energy field strength. This innovative approach can also use radiation and/or chemotherapy in conjunction with the nano-particle illumination to kill the majority of the cancer cells.
    Type: Application
    Filed: January 24, 2011
    Publication date: July 26, 2012
    Applicant: Actium BioSystems, LLC
    Inventors: Daniel B. McKenna, Robert J. Tondu
  • Publication number: 20120157749
    Abstract: A heat therapy for thermally treating a target tissue within a living body by using a treating apparatus including a treating device with a magnetic part is provided. The magnetic part is heated to a first temperature by a high frequency electromagnetic field with a heating rate ranging from 1 to 5° C./sec, wherein the magnetic part is contacted the target tissue. Temperature controlling steps are performed to the magnetic part having the first temperature, and therefore the magnetic part has a final temperature higher than the first temperature, and a treatment is performed to the target tissue under the final temperature. Each of the temperature controlling steps is a heating step, a cooling step or a temperature conservation step, and the magnetic part is heated or cooled by the high frequency electromagnetic field with a heating rate or a cooling rate ranging from 1 to 5° C./sec.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 21, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Gwo-Bin Lee, Xi-Zhang Lin, Sheng-Chieh Huang, Yi-Yuan Chang, Chiung-Yu Chen, Yan-Shen Shan
  • Patent number: 8150532
    Abstract: A system 30 and method(s) 100 for thermal treatment of a selected target within a subject is disclosed. System 30 includes RF source 10, phase shifter 14, impedance matching network 11 and resonator 13. Stationary water molecules 1, such as those in fat cells, are heated. The invention is useful in selective heating of cellulite bodies as a means of treating cellulite.
    Type: Grant
    Filed: June 21, 2009
    Date of Patent: April 3, 2012
    Assignee: Alma Lasers Ltd.
    Inventors: Ziv Karni, Alexander Britva
  • Patent number: 8140169
    Abstract: An induction heating apparatus includes a first interventional device and a second interventional device. The first interventional device includes an electrically conductive material. The first interventional device is adapted for implantation inside a body and for receiving an alternating current. The second interventional device comprises a magnetically conductive material. The second interventional device is adapted for implantation inside the body in close proximity to the first interventional device. With both devices placed inside the body, the second interventional device magnetically couples with the first interventional device and the second interventional device generates heat upon the application of the alternating current to the first interventional device thereby heating the body site.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: March 20, 2012
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Barry N. Gellman, Jozef Slanda, Kimberly Paddock
  • Publication number: 20120010454
    Abstract: A system to induce hyperthermia in a selected portion of the body utilizes permanent magnets mounted on a variable speed motor. A conductive button is positioned at a location proximate the target tissue to be heated, such as a tumor. The magnetic rotor assembly is positioned at a selected distance from the conductive button and rotated at a desired frequency to produce a changing permanent magnetic field that induces an eddy current on the surface of the conductive button. A temperature sensor may be positioned near the conductive button as a feedback mechanism to a control circuit. At higher magnetic polarity frequencies, the conductive button may be implemented in the form of metallic nanoparticles. In this embodiment, the nanoparticles may include molecular elements that selectively bind with the target tissue and thereby accumulate at the target tissue prior to the introduction of the rotating magnetic field.
    Type: Application
    Filed: July 9, 2010
    Publication date: January 12, 2012
    Inventor: Karl J. Lamb
  • Publication number: 20110224479
    Abstract: Technologies are generally described for hyperthermia based treatment of diseased tissues using conductive particles. Conductive particles of known composition and size distribution may be implanted in diseased tissue and exposed to an alternating magnetic field, which may be tuned to the size of the metal particles to induce eddy currents producing heat in the implanted particles. As the temperature of the metal particles increases, their resistance also increases due to their positive temperature coefficient of resistivity. An antenna placed externally to the body near metal particles may be part of a tuned RF circuit and scanned for resonance. The change either in resonance frequency or circuit impedance may provide tuned feedback, which may be used to control the hyperthermia treatment.
    Type: Application
    Filed: March 11, 2010
    Publication date: September 15, 2011
    Applicant: Empire Technology Development, LLC
    Inventor: Thomas A. Yager
  • Publication number: 20110160515
    Abstract: The invention relates to an alternating magnetic field application device for heating magnetic or magnetizable substances in biological tissue, in particular for thermal therapy using magnetic nanoparticles, composed of a large applicator (1) having a magnetic yoke (2) and two oppositely situated pole shoes (7, 8) on the magnetic yoke (2) which are separated by an exposure gap (13), and having two magnetic coils (9, 10), which are respectively associated with a pole shoe (7, 8), for generating a substantially homogenous alternating magnetic field (12) of a given field strength in the exposure gap (13), wherein the biological tissue to be irradiated may he brought into the exposure gap (13) as an exposure target volume.
    Type: Application
    Filed: March 6, 2009
    Publication date: June 30, 2011
    Inventors: Peter Feucht, Volker Brüss, Andreas Jordan
  • Publication number: 20110077580
    Abstract: An in vivo cancer treatment system includes a plurality of bio-medical units, a communication control device, and a wireless power source device. A bio-medical unit of the plurality of bio-medical units includes a power harvesting module operable to convert a wireless power source into a supply voltage; a communication module operable to communication data, wherein the communication unit is powered by the supply voltage; and a field generation module operable to generate a type of electromagnetic field, wherein the field generation module is powered by the supply voltage. The communication control device communicates with the plurality of bio-medical units to facilitate treatment of cancer cells within the body. The wireless power source device generates the wireless power source.
    Type: Application
    Filed: December 29, 2009
    Publication date: March 31, 2011
    Applicant: BROADCOM CORPORATION
    Inventor: Ahmadreza (REZA) ROFOUGARAN
  • Patent number: 7912258
    Abstract: A clinical and training apparatus that collects and processes physical space data while performing an image-guided procedure on an anatomical area of interest includes a calibration probe, a tracked ultrasonic probe, a wireless tracking device that tracks the ultrasonic probe in space and an image data processor. The physical space data provides three-dimensional coordinates for each of the physical points. The image data processor includes a memory holding instructions. The instructions include determining registrations used to indicate position in image space and physical space; using the registrations to map into image space, image data describing the physical space of the tracked ultrasonic probe and the anatomical area of interest; and constructing a three-dimensional (3D) volume based on ultrasonic image data. The apparatus includes a storage medium that stores a plurality of 3D volumes acquired by the image data processor for later retrieval.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: March 22, 2011
    Assignee: Vanderbilt University
    Inventors: John R. Warmath, Alan J. Herline
  • Patent number: 7815570
    Abstract: A methodology and system for lysing adipose tissue including directing ultrasonic energy at a multiplicity of target volumes within the region, which target volumes contain adipose tissue, thereby to selectively lyse the adipose tissue in the target volumes and generally not lyse non-adipose tissue in the target volumes and computerized tracking of the multiplicity of target volumes notwithstanding movement of the body.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: October 19, 2010
    Assignee: Ultrashape Ltd.
    Inventors: Yoram Eshel, Ilia Vitsnudel
  • Publication number: 20100256437
    Abstract: Systems, devices, and methods are described for providing a monitor/treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection.
    Type: Application
    Filed: February 10, 2010
    Publication date: October 7, 2010
    Inventors: Michael C. Hegg, Matthew P. Horning, Jordin T. Kare, Nathan P. Myhrvold, Clarence T. Tegreene, Benjamin K. Wilson, Lowell L. Wood, JR.
  • Patent number: 7751889
    Abstract: An implantable therapy system including implantable stimulation and control components. The implantable components operate under a set of variable parameters that can be adjusted for improved performance for an individual patient. The implantable components are adapted to self-evaluate the patients physiologic performance and autonomously adjust an existing set of parameters to improve performance throughout an implantation period without requiring intervention of a clinician, for example with a physicians programmer. The implantable components can compare a patient's exhibited activity to a desired template of that activity to determine when adjustments are indicated. The template can be based on observations of one or more third parties exhibiting normal activity. The implantable components can adjust the operating parameters to improve synchrony of multiple heart chambers and/or to increase a peak contractility.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: July 6, 2010
    Assignee: Pacesetter, Inc.
    Inventor: Stuart O. Schecter
  • Publication number: 20100113861
    Abstract: A process or method for treating cancer. In one embodiment, the method includes the steps of providing a plurality of metallic nanoparticles, wherein each of the plurality of metallic nanoparticles has a core formed with a first metallic material, and a shell formed with a non-metallic material containing carbon, and wherein the shell is formed to enclose the metallic core completely, introducing said metallic nanoparticles into a mammal such that said metallic nanoparticles selectively target at least one type of cancerous cell, and subsequently applying at least one radio frequency of electromagnetic waves to said mammal for a period of time effective to induce skin currents in the cores of the first metallic material of said metallic nanoparticles to cause heat generated locally around targeted at least one type of cancerous cell to kill said cancerous cell.
    Type: Application
    Filed: October 27, 2009
    Publication date: May 6, 2010
    Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Alexandru S. Biris, Yang Xu, Zhongrui Li, Alexandru R. Biris
  • Patent number: 7684871
    Abstract: Method, system and apparatus for monitoring target tissue temperatures wherein temperature sensors are configured as passive resonant circuits each with a unique resonating signature at monitoring temperatures extending below a select temperature setpoint. The resonant circuits are configured with an inductor component formed of windings about a ferrite core having a Curie temperature characteristic corresponding with a desired temperature setpoint. By selecting inductor winding turns and capacitance values, unique resonant center frequencies are detectable. Temperature monitoring can be carried out with implants at lower threshold and upper limit temperature responses. Additionally, the lower threshold sensors may be combined with auto-regulated heater implants having Curie transitions at upper temperature limits.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: March 23, 2010
    Assignee: Apsara Medical Corporation
    Inventors: Philip E. Eggers, John L. Ridihalgh, Mark Mayerchak, Gary Altman
  • Patent number: 7630774
    Abstract: A system 30 and method(s) 100 for thermal treatment of a selected target within a subject is disclosed. System 30 includes RF source 10, phase shifter 14, impedance matching network 11 and resonator 13. Applicator 3 conveys output signal 17 from energy source 10 through surface 6 of biological tissue 4 to predetermined energy dissipation zone 5 after output 17 has been processed by the phase shifter 14, IMN 11 and resonator 13. Stationary water molecules 1, such as those in fat cells, are heated. System 30 is operative to heat a volume of biological tissue beneath the biological tissue surface 6 such that surface 6 of biological tissue 4 is maintained at a lower temperature than predetermined energy dissipation zone 5 without a cooling device. The invention is useful in selective heating of cellulite bodies as a means of treating cellulite.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: December 8, 2009
    Assignee: Alma Lasers Ltd.
    Inventors: Ziv Karni, Alexander Britva
  • Publication number: 20090124847
    Abstract: A device for automatically aligning bipolar electrodes on opposing sides of operative tissue is provided for performing minimally invasive RF ablation. The device includes complementary magnetic electrode assemblies, each having a permanent magnet mechanically coupled to and electrically insulated from an electrical conductor. When positioned on opposing sides of tissue such as an atrial wall, the complementary assemblies automatically align their respective electrical conductors through mutual magnetic attraction to complete an electrical circuit. Each electrical conductor may provide an alignable elongated transmitting element adjacent to a magnetic coupling surface to allow for ablation of linear segments of tissue. Each electrode assembly includes mechanical linkage for coupling to an intracorporeal positioning device and a wire receiving terminal for connection to an external generator.
    Type: Application
    Filed: November 12, 2007
    Publication date: May 14, 2009
    Inventors: John Richard Doty, Jeffrey L. Anderson
  • Publication number: 20080255403
    Abstract: Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and/or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect.
    Type: Application
    Filed: June 29, 2007
    Publication date: October 16, 2008
    Applicant: ETHICON ENDO-SURGERY, INC.
    Inventors: James W. Voegele, Robert P. Gill
  • Publication number: 20080249350
    Abstract: The present invention improves the cosmetic appearance of skin by controllably heating a superficial layer of skin thereby inducing acute tissue contraction or shrinkage and a wound response leading to the production of biomolecules, all of which result in improved cosmesis. The invention incorporates a source of radiofrequency electrical energy coupled to coil, with requisite impedance matching network, thereby resulting in the production of an alternating magnetic field. When tissue is brought into proximity of the alternating magnetic field, inductive heating of the tissue results as a consequence of either or both of dipole formation and oscillation, and eddy current formation. Optionally, cooling is provided to remove heat from the coil, the source of radiofrequency electrical energy, or the surface of the skin alone or in combination.
    Type: Application
    Filed: April 7, 2008
    Publication date: October 9, 2008
    Inventors: Kevin S. Marchitto, Stephen T. Flock
  • Publication number: 20080221385
    Abstract: A medical technology device has an x-ray CT imaging system and a magnet system for generation of a radio-frequency alternating magnetic field for treatment of a tumor injected with ferrite nanoparticles, the x-ray CT system and the magnet system being combined to form a unitary structure. Imaging and tumor therapy can be conducted with one apparatus, and the monitoring of the course of the tumor therapy is simplified.
    Type: Application
    Filed: September 12, 2007
    Publication date: September 11, 2008
    Inventor: Peter Aulbach