Magnetic Element Placed Within Body (e.g., Injected, Inserted, Implanted, Etc.) Patents (Class 600/12)
  • Patent number: 11406840
    Abstract: Systems and methods for reducing blood viscosity along a flow direction, suppressing turbulence in blood flow, and treating rouleaux are disclosed. One method includes applying a unidirectional magnetic field to a flow of blood in a direction parallel or antiparallel to a direction of the flow of blood, and maintaining the application of the unidirectional magnetic field to the flow of blood until a blood viscosity along the direction of the flow of blood is reduced and/or the turbulence in the blood flow is suppressed. One system includes an annular magnet sized to encircle a portion of a patient's body. The magnet is adapted to generate a unidirectional magnetic field in a region within the annular magnet. The unidirectional magnetic field has a strength sufficient to reduce the blood viscosity in the portion of the patient's body and/or suppress turbulence in the blood flow by a predetermined amount. The system will also break rouleaux for patients with rouleaux, but the process will take more time.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: August 9, 2022
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventors: Rongjia Tao, Hong Tang, Xiaojun Xu, Kazi M. Tawhid-Al-Islam, Enpeng Du
  • Patent number: 11389171
    Abstract: Described are coordinated apparatus and methods for drug targeting, clearing the lumen, placing implants within the wall of, and stenting, as necessary, any tubular anatomical structure with single luminal entry. Miniature balls, or miniballs, are introduced into the wall aeroballistically from within the lumen, or small arcuate bands called stays inserted through the outer tunic by means of a hand tool. When miniballs must be placed too closely together to be controlled by hand, a positional control system assists in discharge. Implantation within or proximal to diseased tissue targeting, and thus concentrating the medication in that tissue, miniballs and stays can be used to deliver and controllably release multiple drugs, a radionuclide, or an open or closed loop smart-pill, for example. A glossary of terms follows the specification. Balance of abstract appended to the section entitled Summary of the Invention.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: July 19, 2022
    Inventor: David S. Goldsmith
  • Patent number: 11382526
    Abstract: A system for generating a traveling field free line, traveling along a propagation direction different from the orientation of said traveling field free line, said system comprising at least a first and a second coil assembly, wherein said first coil assembly is configured for generating a first stationary field free line at a first location when a current is flowing in the first coil assembly and the second coil assembly is current free, and wherein said second coil assembly is configured for generating a second stationary field free line at a second location, when a current is flowing in the second coil assembly and the first coil assembly is current free. The system further comprises a controller configured for driving the first and second coil assemblies with corresponding driving currents synchronized with each other, such that said traveling field free line travels along the propagation direction from a first location towards a second location.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: July 12, 2022
    Assignee: Julius-Maximilians-Universität Würzburg
    Inventors: Patrick Vogel, Martin Rückert, Volker Christian Behr
  • Patent number: 11350867
    Abstract: Systems and methods for quantifying cardiac electrophysiologic signals. An electronic processor receives a unipolar electrogram signal from each of a plurality of electrodes positioned at different locations of a heart. The electronic processor then calculates or measures a bipolar electrogram signal based on a difference between the unipolar electrogram signal for a first electrode and the unipolar electrogram signal for a second electrode. A local activation time (LAT) difference between a location of the first electrode and a local of the second electrode is then determined based on a voltage amplitude of the bipolar electrogram signal. The LAT difference is indicative of an amount of time between a local activation of a propagating wavefront at the location of the first electrode and a local activation of the propagating wavefront at the location of the second electrode.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: June 7, 2022
    Assignee: Duke University
    Inventor: Stephen Gaeta
  • Patent number: 11298009
    Abstract: Provided is and electrode selection device communicating with a capsule endoscope. The device includes an analog front end configured to recover first data based on first signals transmitted from the capsule endoscope to a first electrode and a second electrode, recover second data based on second signals transmitted from the capsule endoscope to the first electrode and a third electrode, and recover third data based on third signals transmitted from the capsule endoscope to the second electrode and the third electrode, and a digital receiver configured to calculate a first correlation value between the first and second electrodes, a second correlation value between the first and third electrodes, and a third correlation value between the second and third electrodes based on the first to third data. The digital receiver calculates first to third correlation sums, and selects a receiving electrode pair based on the first to third correlation sums.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: April 12, 2022
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Mi Jeong Park, Hyung-Il Park, Tae Wook Kang, Sung Eun Kim, Hyuk Kim, Kwang Il Oh, Jae-Jin Lee, In Gi Lim
  • Patent number: 11229705
    Abstract: The present invention relates to the medical field, in particular to the modulation of electrical polarization of neurons.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: January 25, 2022
    Assignee: NANOBIOTIX
    Inventors: Agnès Pottier, Laurent Levy, Marie-Edith Meyre
  • Patent number: 11224735
    Abstract: The present invention relates to an implantable device for improving the pump function of the heart of a human patient by applying an external force on the heart muscle, said device comprising at least one pump device comprising: a first part having a first surface, and a second part having a second surface. The first part is displaceable in relation to the second part and said first and second surfaces abut each other, at least partially. The second part exerts, directly or indirectly, force on an external part of said heart muscle.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: January 18, 2022
    Inventor: Peter Forsell
  • Patent number: 11166782
    Abstract: Implantable magnetic markers (seeds) provide a higher degree of flexibility and convenience. The magnetic field that a marker provides is determined by the magnetic properties of the materials used and the dimensions of the marker—in general, a larger marker is easier to locate. Larger diameter markers may be used, but they should be much smaller than the average tumor size if they are to provide a useful degree of localization. An implantable magnetic marker is provided with two or more magnetic elements comprising permanent magnets connected by a mechanical connector to resiliently retain a first orientation when deployed and a second orientation before and/or during implantation. This allows complex magnetic configurations to be implanted, while retaining a simplified implantation method independent of the number of magnetic elements used.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: November 9, 2021
    Inventors: Bram Schermers, Adrianus Cornelis Petrus Van Leijsen, Hubert Cecile Francois Martens
  • Patent number: 11103720
    Abstract: This invention presents methods for targeting and killing types of cells or organisms using Magneto-Electric Nano-Particles under the control of an external magnetic field. A method was also presented for using Magneto-Electric Nano-Particles to stimulate or rejuvenate cells under an external magnetic field.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: August 31, 2021
    Inventor: Ping Liang
  • Patent number: 11007357
    Abstract: Systems and methods of localizing or delivery cells, biologics and/or drugs to a specific target area to treat pelvic health disorders are provided. A treatment composition including cells, biologics and/or drugs are associated with magnetic particulates, and the positioning of these materials is facilitated through use of a magnetic field-generating device that is configured to be placed on or into a pelvic anatomical structure. Certain embodiments directed to the treatment of ED in male patients can include a cell based therapy system.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: May 18, 2021
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Natalie Ann Borgos, Tania M. Schroeder, David J. Yonce, Robert E. Lund, Suranajan Roychowdhury
  • Patent number: 11000408
    Abstract: [Summary] [Problem] The therapy method and the therapy apparatus for difficult cancer such as ductal cancer and other diseases. [Solution to problem] The therapy and the apparatus to beat cancer and other diseases by injecting the material which is energy receptive from outside and emissive heat to cancer cells in the body of a patient, and giving energy from outside.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: May 11, 2021
    Inventor: Yoshiro Sir NakaMats
  • Patent number: 10974060
    Abstract: This invention presents methods for targeting and killing types of cells or organisms using Magneto-Electric Nano-Particles under the control of an external magnetic field. A method was also presented for using Magneto-Electric Nano-Particles to stimulate or rejuvenate cells under an external magnetic field.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: April 13, 2021
    Inventor: Ping Liang
  • Patent number: 10948556
    Abstract: Disclosed herein are a method for modifying a magnetic field using magnetic nanoparticles and an apparatus therefor. The method for modifying a magnetic field includes applying current to a single solenoid coil or to two parallel solenoid coils, measuring a strength of a magnetic field generated by the current at a preset target location using a measurement sensor, and controlling the strength of the magnetic field based on a concentration of a magnetic nanoparticle sample mounted in the single solenoid coil or the two solenoid coils so that the strength of the magnetic field matches a preset target value.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: March 16, 2021
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Hyo-Bong Hong, Jae-Chan Jeong, Seung-Min Choi, Chang-Beom Kim
  • Patent number: 10869732
    Abstract: Methods and apparatuses for applying tensile force to one or more tissue regions within a body. Illustratively, an implant ball including a spherical side wall is received within a tubular organ, and tensile sutures extend through the implant ball for applying a tensile force to facilitate elongation of the tubular organ.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: December 22, 2020
    Assignee: Children's Hospital Medical Center
    Inventor: Jose Peiro Ibanez
  • Patent number: 10813997
    Abstract: A system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator is provided. In one embodiment, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: October 27, 2020
    Assignee: Pulse Therapeutics, Inc.
    Inventor: Francis M. Creighton
  • Patent number: 10729470
    Abstract: A method of positioning an external adjustment device relative to a patient includes placing a magnetic viewing sheet adjacent to a patient and identifying the location of an implanted magnetic assembly using the magnetic viewing sheet by visualizing a magnetic image of the implanted magnetic assembly in the magnetic viewing sheet. The external adjustment device is placed on the patient adjacent to the location where the magnetic image was located.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: August 4, 2020
    Assignee: NuVasive Specialized Orthopedics, Inc.
    Inventors: Scott Pool, Blair Walker, Arvin Chang
  • Patent number: 10584688
    Abstract: A system is described comprising self-propelled bodies such as bacteria or nanoparticles, which can be activated with an external field to move in a desired direction. The self-propelled bodies, or swimmers, are contained in a flexible membrane which is mechanically manipulated through the movement of the swimmers. By controlling the applied field, which can be magnetic, chemical or gravitational, the flexible membranes can be translated and/or deformed.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: March 10, 2020
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Sho C. Takatori, John F. Brady
  • Patent number: 10551374
    Abstract: According to the invention there is provided a method of detecting an analyte including the steps of: i) providing a sample which contains the analyte and magnetic nanoparticles, in which the magnetic nanoparticles include a magnetic body portion which acts as a signalling vector and at least one receptor moiety attached to the body portion for binding to the analyte; ii) applying a magnetic field across at least a portion of the sample to orient the magnetic nanoparticles with respect to the applied magnetic field; iii) introducing electromagnetic radiation into the sample; iv) detecting a physical property which varies in dependence on the orientation of the magnetic nanoparticles with respect to the applied magnetic field, wherein the physical property is associated with the interaction of the electromagnetic radiation with the magnetic body portion which thereby acts as a signalling vector; and v) correlating the detected physical property with the presence of the analyte.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: February 4, 2020
    Assignee: COTTON MOUTON DIAGNOSTICS LIMITED
    Inventors: David Newman, Raphael Matelon
  • Patent number: 10500086
    Abstract: An orthotic obstructive sleep apnea treatment device is provided that includes a hyoid bone attachment element disposed to attach a ferric element to a hyoid bone, where the ferric element is disposed to face along a treatment vector from the hyoid bone, and the treatment vector is oriented relative to a sagittal plane of a human. The orthotic obstructive sleep apnea treatment device further includes an external orthotic neck device having a contoured housing with a shape disposed to conform about a neck of the human subject, where the housing includes a force delivery element disposed at an exterior-front neck region of the human subject and is disposed to provide an attractive force to the ferric element along the treatment vector. A force sensor is disposed to measure a force exerted on the hyoid bone, a skin contact pressure, tissue compression between the ferric element and the force delivery element.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: December 10, 2019
    Assignee: The Regents of the University of California
    Inventors: Michael R. Harrison, Kathryn H. Rosenbluth, Dillon A. Kwiat, Eric J. Kezirian, Richard J. Fechter, Darrell Christensen
  • Patent number: 10485975
    Abstract: An exemplary electroacupuncture device may be implanted beneath a skin surface of a patient at a location corresponding to a joint affected by osteoarthritis and may perform methods for treating the osteoarthritis. In some implementations, the electroacupuncture device is powered by a primary battery located within the electroacupuncture device and having an internal impedance greater than 5 ohms and a capacity of less than 60 milliamp-hours (mAh).
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: November 26, 2019
    Assignee: Valencia Technologies Corporation
    Inventors: Jeffrey H. Greiner, David K. L. Peterson, Stacy Greiner Chambliss
  • Patent number: 10456363
    Abstract: The invention discloses a composition comprising surface modified iron oxide nanoparticles with citric acid modified cyclodextrin with a hydrodynamic diameter of less than 10 nm and a hydrophobic molecule. The composition finds use in targeted delivery of a hydrophobic drug and as contrast agent in imaging applications.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: October 29, 2019
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Pattayil Joy, Jayaprabha Kunnoth Naduvilidam
  • Patent number: 10446308
    Abstract: Applicants have discovered a novel apparatus and method to aggregate and displace a plurality of magneto-responsive entities (steerable self-propelled entities or SSPEs) in three dimensions using time-multiplexing. The apparatus for controlling aggregation of SSPEs in a body comprises at least three sets of magnetic field sources arranged in three axes for generating a controlled magnetic field and a controller connected to at least one of said magnetic field sources to create a three dimensional convergence point. The method for aggregating the entities can comprise using a first set and a second set of said magnetic field sources to generate opposed magnetic field gradients in each said set to cause aggregation of said magneto-responsive entities in two axes and wherein the controller is configured to reverse a direction of said magnetic field gradient in a third set of magnetic field sources in a third axis according to a first predetermined program.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: October 15, 2019
    Assignee: POLYVALOR, LIMITED PARTNERSHIP
    Inventors: Sylvain Martel, Ouajdi Felfoul
  • Patent number: 10406331
    Abstract: A subcutaneous implantable device has one or more adjustable settings with a setting device configured to selectively change between the one or more adjustable settings. An indicator, having an ultrasound reflection enhancement, indicates each particular setting of the one or more adjustable settings.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: September 10, 2019
    Assignee: INTEGRA LIFESCIENCES SWITZERLAND SÀRL
    Inventor: Donald Barry
  • Patent number: 10383764
    Abstract: An eyelid implant device adapted for placement under an eyelid includes a body having an upper portion and a lower portion, where the upper portion and the lower portion include an asymmetrical weight distribution, such that the lower portion includes an increased weight distribution relative to the upper portion for facilitating the weighting of the eyelid. A plurality of undulations are located on the outer surface of the trapezoidal shaped body and extend in a direction between opposing parallel bases of the body. The eyelid implant is adapted for placement under the eyelid for weighting the eyelid and facilitating eyelid movement, while the plurality of undulations are adapted to restrict post-operative movement of the eyelid implant device relative to the eyelid by contacting with tissue associated with the eyelid during post-operative healing.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: August 20, 2019
    Inventor: Ebrahim Elahi
  • Patent number: 10357733
    Abstract: A system and method for removing retentate from filters is disclosed, which utilizes pressurized and/or vacuum fluid through localized application. The disclosure describes a cleaning system and sequence of steps for carrying out the cleaning process, whereby, a fluid is directed to flow through a localized region of the filter media, thereby dislodging and removing accumulated retentate from the filter. In addition, the localized application of fluid flow allows for localized monitoring of the cleanliness of the filter with a high degree of spatial resolution. This filter retentate removal system and method is broadly applicable to a wide range of systems and processes ranging to engines and exhaust systems to production plants and equipment.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: July 23, 2019
    Assignee: CTS Corporation
    Inventors: Paul Ragaller, Alexander Sappok, Leslie Bromberg
  • Patent number: 10350145
    Abstract: A system comprising a nasogastric tube comprising a nasogastric location element, a feeding mechanism, a suction mechanism configured to sealingly draw an inner wall of an esophagus against said nasogastric tube, and a gastric decompression mechanism.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: July 16, 2019
    Assignee: ENVIZION MEDICAL LTD.
    Inventors: Doron Besser, Guy Ben Ezra
  • Patent number: 10285934
    Abstract: A method of administering a drug into the brain of a mammal (human or nonhuman) is described. In this method, a magneto-electric nanoparticle (MENP) and a drug are injected into the blood stream of a mammal. The MENP attaches to the blood-brain barrier (BBB) and a non-alternating electric or magnetic field is applied. In an alternative, the non-alternating field could be replaced by a slowly alternating field so as to avoid localized heating. The step of applying an electric or magnetic field causes an increase in the permeability of the BBB to the drug so that the drug passes into the brain while the MENP remains attached to the BBB.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: May 14, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Gaurav Sharma, Chad Bouton
  • Patent number: 10173062
    Abstract: Implanted pulse generators with reduced power consumption via signal strength-duration characteristics, and associated systems and methods are disclosed. A representative method for treating a patient in accordance with the disclosed technology includes receiving an input corresponding to an available voltage for an implanted medical device and identifying a signal delivery parameter value of an electrical signal based on a correlation between values of the signal delivery parameter and signal deliver amplitudes. The signal deliver parameter can include at least one of pulse width or duty cycle. The method can further include delivering an electrical therapy signal to the patient at the identified signal delivery parameter value using a voltage within a margin of the available voltage.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: January 8, 2019
    Assignee: Nevro Corp.
    Inventor: Jon Parker
  • Patent number: 10029094
    Abstract: A method for treating neural deficits resulting from multiple sclerosis, involving assessing a subject's motor, sensory, cognitive, or emotional deficits caused by multiple sclerosis; selecting a rehabilitative task based said deficits; determining the subject's acceptable performance threshold for the rehabilitative task; and providing a paired training therapy. The paired training therapy comprises having the subject to perform a trial of the rehabilitative task; classifying the subject's performance on the trial as either acceptable or unacceptable, wherein an acceptable performance is performance at or above the subject's acceptable performance threshold, and an unacceptable performance is performance below the subject's acceptable performance threshold; and reinforcing acceptable performance by selectively stimulating the subject's vagus nerve after completion of the acceptable performance.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: July 24, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michael P. Kilgard, Robert L. Rennaker, II
  • Patent number: 9974546
    Abstract: A guide and remote traction system for mini-invasive surgery in a body cavity that is easily positioned and hooked and causes lower injury, comprising: at least one detachable surgical endoclamp (10) with hooking means (11, 12), assembled with an introduction guide (20) and at an initially open position; and at a naturally closed position when detached from said introduction guide (20) by a detachment mechanism; said endoclamp (10) comprising a portion of ferromagnetic material at the end opposed to said hooking means (11, 12); a cylindrically-shaped introduction guide (20) assembled with said detachable surgical endoclamp (10), said introduction guide (20) comprising a mechanism to detach said endoclamp (10); and at least one remote traction means (30) for said endoclamp (10), acting through the application of an electromagnetic field over the ferromagnetic portion of said endoclamp (10).
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: May 22, 2018
    Assignee: Levita Magnetics International Corp.
    Inventors: Manuel Rodriguez Fernandez, Alberto Rodriguez Navarro
  • Patent number: 9955889
    Abstract: Cardiac catheterization is facilitated by generating first and second electroanatomic maps of a heart of a subject and designating common spatial locations that correspond to first electrical events on the first electroanatomic map and second electrical events on the second electroanatomic map. The common spatial locations of the first electroanatomic map and the second electroanatomic map are aligned to establish an aligned map, and using the location data on the aligned map to guide a probe to a point of interest.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: May 1, 2018
    Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
    Inventors: Roy Urman, Ronen Krupnik, Liron Shmuel Mizrahi
  • Patent number: 9931429
    Abstract: A particle includes a ferromagnetic material, a radiopaque material, and/or an MRI-visible material.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: April 3, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Robert F. Rioux, Thomas V. Casey, II, Janel Lanphere
  • Patent number: 9855164
    Abstract: Methods and devices comprised of a collapsible insert member and shaping member for treating obstructive sleep apnea are described. The insert member is placed in the tongue or other tissue forming the airway of the patient and has a lumen to accommodate the shaping member. The shaping member is inserted into the insert member by the patient just prior to sleep and removed upon waking. A variety of shaping members are available to treat patients on an individual basis, i.e., to match their particular anatomic condition that is causing their apnea or snoring. The shaping member can be made from nitinol, stainless steel, or any other known biocompatible implant material capable of providing a change in the tissue response to stress.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: January 2, 2018
    Assignee: Ethicon, Inc.
    Inventors: Kevin Weadock, Robert A. Rousseau
  • Patent number: 9844391
    Abstract: A guide and remote traction system for mini-invasive surgery in a body cavity that is easily positioned and hooked and causes lower injury, comprising: at least one detachable surgical endoclamp (10) with hooking means (11, 12), assembled with an introduction guide (20) and at an initially open position; and at a naturally closed position when detached from said introduction guide (20) by a detachment mechanism; said endoclamp (10) comprising a portion of ferromagnetic material at the end opposed to said hooking means (11, 12); a cylindrically-shaped introduction guide (20) assembled with said detachable surgical endoclamp (10), said introduction guide (20) comprising a mechanism to detach said endoclamp (10); and at least one remote traction means (30) for said endoclamp (10), acting through the application of an electromagnetic field over the ferromagnetic portion of said endoclamp (10).
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: December 19, 2017
    Assignee: Levita Magnetics International Corp.
    Inventors: Manuel Rodriguez Fernandez, Alberto Rodriguez Navarro
  • Patent number: 9755231
    Abstract: Provided are a method of preparing iron oxide nanoparticles, iron oxide nanoparticles prepared thereby, and an anode material including the iron oxide nanoparticles.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: September 5, 2017
    Assignee: LG Chem, Ltd.
    Inventors: Myung Ki Lee, Sung Bin Park, Sung Joong Kang, Wang Mo Jung
  • Patent number: 9669232
    Abstract: Magneto-electric nanoparticles in a subject interact with an external magnetic field to cause stimulation of neural networks in the subject. Electric signals in the neural network are coupled to magnetic dipoles induced in the nanoparticles to cause changes in electric pulse sequences of the subject's brain.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: June 6, 2017
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Sakhrat Khizroev, Madhavan P. N. Nair
  • Patent number: 9669200
    Abstract: Systems and methods of localizing or delivery cells, biologics and/or drugs to a specific target area to treat pelvic health disorders are provided. A treatment composition including cells, biologics and/or drugs are associated with magnetic particulates, and the positioning of these materials is facilitated through use of a magnetic field-generating device that is configured to be placed on or into a pelvic anatomical structure. Certain embodiments directed to the treatment of ED in male patients can include a cell based therapy system.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: June 6, 2017
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Natalie Ann Borgos, Tania M. Schroeder, David J. Yonce, Robert E. Lund, Suranajan Roychowdhury
  • Patent number: 9656058
    Abstract: Techniques for insertion of a cochlear implant include using a rotatable manipulator magnet to steer the tip of the cochlear implant. Steering can use magnetic torque and/or force between the manipulator magnet and a magnetic element coupled to the tip of the cochlear implant to control bending of the cochlear implant.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: May 23, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Jacob J. Abbott, James R. Clark, Frank M. Warren
  • Patent number: 9561158
    Abstract: An illuminating bridle catheter installation system includes a flexible member having a leading end and a trailing end with a first magnet coupled to the leading end of the flexible member, and a retrieving member having a leading end and a trailing end with two non-contacting second magnets coupled to the leading end of the retrieving member. An illuminating member is coupled to one of the flexible member or the retrieving member and the illuminating member is coupled to an electronic circuit having a switch that allows the illuminating member to be illuminated when the first magnet meets the second magnets.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 7, 2017
    Assignee: APPLIED MEDICAL TECHNOLOGY, INC.
    Inventor: George J. Picha
  • Patent number: 9510959
    Abstract: A device for use in reducing or preventing the occurrence of restenosis following procedures such as PTCA, in which a stent is used to hold a bodily lumen open. The device comprises a two layered stent, one lying within the other. Both stent layers have an open weave structure, such that they can expand to the correct dimensions after implantation. The outer stent layer is static and grips the inner wall of the lumen in which it is deployed in the usual manner. The inner layer stent is constructed such that it can be vibrated relative to the outer static stent layer. The inner layer stent may be made of a material which can be vibrated from an external source, such as a ferromagnetic material. This vibration prevents restenosis of the treated lumen. Alternatively, a vibrator, such as a piezoelectric device, can be installed on the inner stent layer.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: December 6, 2016
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Moshe Shoham, Amit Reches, Lucy Leshansky, Michael Groskop, Shachar Millis, Yishai Pentanovich
  • Patent number: 9427466
    Abstract: Methods for reducing the growth of breast cancer cells in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold or magnetic nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: August 30, 2016
    Assignee: Academia Sinica
    Inventors: Olga K. Kosheleva, Peter Lai, Nelson G. Chen, Michael Hsiao, Chung-Hsuan Chen
  • Patent number: 9421015
    Abstract: A system and method for endoscopically forming an anastomosis between two naturally adjacent points in the digestive tract. The system and method utilizes elongate magnetic devices that, when connected across a tissue boundary, necrose tissue until an anastomosis forms and the devices are passed naturally. Despite the elongate shape of the devices, the resulting anastomosis is substantially round. As such, round anastomoses can be formed having increased diameters merely by increasing the lengths of the devices, obviating the need for wider endoscopes.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: August 23, 2016
    Inventors: Michel Gagner, David J. Blaeser, Todd A. Krinke, Philip J. Haarstad
  • Patent number: 9302104
    Abstract: Devices, systems, and methods for automated optimization of muscle stimulation energy. In some embodiments the disclosure optimizes stimulation parameters and/or stimulation location.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: April 5, 2016
    Assignee: NIVEUS MEDICAL, INC.
    Inventor: Brian J. Fahey
  • Patent number: 9272158
    Abstract: Magneto-electric nanoparticles in a subject interact with an external magnetic field to cause stimulation of neural networks in the subject. Electric signals in the neural network are coupled to magnetic dipoles induced in the nanoparticles to cause changes in electric pulse sequences of the subject's brain.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: March 1, 2016
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Sakhrat Khizroev, Madhavan P. N. Nair
  • Patent number: 9233163
    Abstract: A prodrug according to formula (I) wherein R2 is a residue of a drug, said drug having a hydroxyl group by which the COOR2 group is formed; Z is O or NH; m is 0 or 1; and R3 is an organic moiety comprising a lipophilic group or a residue of a polymer, provided that Z is 0 if the polymer is carboxymethyl dextran. A system includes a plurality of magnetic nanoparticles including a prodrug as described above, a stent and a source of uniform magnetic field capable of producing temporary magnetization of the stent and/or the magnetic nanoparticles. A method of treating a medical condition with a drug includes administering to a patient in need of the drug a prodrug as described above, the prodrug being capable of releasing the drug in the patient after the administration step.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: January 12, 2016
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Ivan Alferiev, Michael Chorny, Robert J. Levy
  • Patent number: 9211422
    Abstract: The system and methods of the invention partially shields the radiation dose to the skin and/or other anatomical organs by using magnetically responsive material that blocks radiation, which may be fine grains of iron or other ferrous powder for example. The powder is typically injected into an IB applicator, along with inflating saline solution in case of MSB, when a skin spacing problem is encountered, or there is a risk of high doses being delivered to the critical organs surrounding a lumpectomy cavity, for example. A slight magnetic field of predetermined configuration will be applied externally to arrange the shielding material internally under the segment of surface of the IB applicator where the skin spacing is typically less than 7 mm, thereby protecting the skin from radiation damage. Monte Carlo studies to develop parameterizations for treatment planning with the IB applicator utilizing the suggested shielding material is also provided.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: December 15, 2015
    Assignee: Hampton University
    Inventors: Cynthia E. Keppel, Vahagn R. Nazaryan
  • Patent number: 9174045
    Abstract: Transcutaneous electrical and magnetic nerve stimulation devices and methods generate energy that is delivered noninvasively to selected nerve fibers within the patient to treat lower urinary tract disorders. The disorders comprise overactive bladder, urge incontinence, stress, incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis/painful bladder syndrome. In preferred embodiments, a posterior tibial nerve of a patient is stimulated non-invasively to treat bladder disorders.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: November 3, 2015
    Assignee: Electrocore, LLC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 9173714
    Abstract: An anchoring device for use within a body cavity during a surgical procedure is disclosed. The anchoring device includes an external assembly, an internal assembly, a controller, and a module. The external assembly has a first magnetic component. The internal assembly has a second magnetic component. The internal assembly is sized to be placed inside of the body cavity. The electrical current is connected with one of the first and the second magnetic component to produce a magnetic field about the connected magnetic component to approximate the internal and external assemblies. The module determines a parameter and is in communication with a controller. The controller controls the electrical current in response to the parameter.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: November 3, 2015
    Assignee: Covidien LP
    Inventor: Frank J. Viola
  • Patent number: 9161856
    Abstract: Devices, systems, and methods employ at least one ferromagnetic structure sized and configured for placement in a tissue region. A component is attached to the structure to stabilize its placement in the tissue region. An anchoring structure holds the component in a state of tension. The anchoring structure can, e.g., take the from of an anchoring body that expands in situ. The anchoring structure can be adjustable for adjusting the state of tension. The component can be elastic, to deflect under load in a prescribed manner and to recover an initial shape when unloaded.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: October 20, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Lionel M. Nelson, Octavian Iancea, Brian K. McCollum, Andres D. Tomas
  • Patent number: 9108035
    Abstract: Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: August 18, 2015
    Assignees: University of Maryland, College Park, The United States of America as represented by the Secretary, Department of Health and Human Services, National Institutes of Health
    Inventors: Benjamin Shapiro, Michael R. Emmert-Buck