Magnetic Element Placed Within Body (e.g., Injected, Inserted, Implanted, Etc.) Patents (Class 600/12)
  • Patent number: 10551374
    Abstract: According to the invention there is provided a method of detecting an analyte including the steps of: i) providing a sample which contains the analyte and magnetic nanoparticles, in which the magnetic nanoparticles include a magnetic body portion which acts as a signalling vector and at least one receptor moiety attached to the body portion for binding to the analyte; ii) applying a magnetic field across at least a portion of the sample to orient the magnetic nanoparticles with respect to the applied magnetic field; iii) introducing electromagnetic radiation into the sample; iv) detecting a physical property which varies in dependence on the orientation of the magnetic nanoparticles with respect to the applied magnetic field, wherein the physical property is associated with the interaction of the electromagnetic radiation with the magnetic body portion which thereby acts as a signalling vector; and v) correlating the detected physical property with the presence of the analyte.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: February 4, 2020
    Assignee: COTTON MOUTON DIAGNOSTICS LIMITED
    Inventors: David Newman, Raphael Matelon
  • Patent number: 10500086
    Abstract: An orthotic obstructive sleep apnea treatment device is provided that includes a hyoid bone attachment element disposed to attach a ferric element to a hyoid bone, where the ferric element is disposed to face along a treatment vector from the hyoid bone, and the treatment vector is oriented relative to a sagittal plane of a human. The orthotic obstructive sleep apnea treatment device further includes an external orthotic neck device having a contoured housing with a shape disposed to conform about a neck of the human subject, where the housing includes a force delivery element disposed at an exterior-front neck region of the human subject and is disposed to provide an attractive force to the ferric element along the treatment vector. A force sensor is disposed to measure a force exerted on the hyoid bone, a skin contact pressure, tissue compression between the ferric element and the force delivery element.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: December 10, 2019
    Assignee: The Regents of the University of California
    Inventors: Michael R. Harrison, Kathryn H. Rosenbluth, Dillon A. Kwiat, Eric J. Kezirian, Richard J. Fechter, Darrell Christensen
  • Patent number: 10485975
    Abstract: An exemplary electroacupuncture device may be implanted beneath a skin surface of a patient at a location corresponding to a joint affected by osteoarthritis and may perform methods for treating the osteoarthritis. In some implementations, the electroacupuncture device is powered by a primary battery located within the electroacupuncture device and having an internal impedance greater than 5 ohms and a capacity of less than 60 milliamp-hours (mAh).
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: November 26, 2019
    Assignee: Valencia Technologies Corporation
    Inventors: Jeffrey H. Greiner, David K. L. Peterson, Stacy Greiner Chambliss
  • Patent number: 10456363
    Abstract: The invention discloses a composition comprising surface modified iron oxide nanoparticles with citric acid modified cyclodextrin with a hydrodynamic diameter of less than 10 nm and a hydrophobic molecule. The composition finds use in targeted delivery of a hydrophobic drug and as contrast agent in imaging applications.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: October 29, 2019
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Pattayil Joy, Jayaprabha Kunnoth Naduvilidam
  • Patent number: 10446308
    Abstract: Applicants have discovered a novel apparatus and method to aggregate and displace a plurality of magneto-responsive entities (steerable self-propelled entities or SSPEs) in three dimensions using time-multiplexing. The apparatus for controlling aggregation of SSPEs in a body comprises at least three sets of magnetic field sources arranged in three axes for generating a controlled magnetic field and a controller connected to at least one of said magnetic field sources to create a three dimensional convergence point. The method for aggregating the entities can comprise using a first set and a second set of said magnetic field sources to generate opposed magnetic field gradients in each said set to cause aggregation of said magneto-responsive entities in two axes and wherein the controller is configured to reverse a direction of said magnetic field gradient in a third set of magnetic field sources in a third axis according to a first predetermined program.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: October 15, 2019
    Assignee: POLYVALOR, LIMITED PARTNERSHIP
    Inventors: Sylvain Martel, Ouajdi Felfoul
  • Patent number: 10406331
    Abstract: A subcutaneous implantable device has one or more adjustable settings with a setting device configured to selectively change between the one or more adjustable settings. An indicator, having an ultrasound reflection enhancement, indicates each particular setting of the one or more adjustable settings.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: September 10, 2019
    Assignee: INTEGRA LIFESCIENCES SWITZERLAND SÀRL
    Inventor: Donald Barry
  • Patent number: 10383764
    Abstract: An eyelid implant device adapted for placement under an eyelid includes a body having an upper portion and a lower portion, where the upper portion and the lower portion include an asymmetrical weight distribution, such that the lower portion includes an increased weight distribution relative to the upper portion for facilitating the weighting of the eyelid. A plurality of undulations are located on the outer surface of the trapezoidal shaped body and extend in a direction between opposing parallel bases of the body. The eyelid implant is adapted for placement under the eyelid for weighting the eyelid and facilitating eyelid movement, while the plurality of undulations are adapted to restrict post-operative movement of the eyelid implant device relative to the eyelid by contacting with tissue associated with the eyelid during post-operative healing.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: August 20, 2019
    Inventor: Ebrahim Elahi
  • Patent number: 10357733
    Abstract: A system and method for removing retentate from filters is disclosed, which utilizes pressurized and/or vacuum fluid through localized application. The disclosure describes a cleaning system and sequence of steps for carrying out the cleaning process, whereby, a fluid is directed to flow through a localized region of the filter media, thereby dislodging and removing accumulated retentate from the filter. In addition, the localized application of fluid flow allows for localized monitoring of the cleanliness of the filter with a high degree of spatial resolution. This filter retentate removal system and method is broadly applicable to a wide range of systems and processes ranging to engines and exhaust systems to production plants and equipment.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: July 23, 2019
    Assignee: CTS Corporation
    Inventors: Paul Ragaller, Alexander Sappok, Leslie Bromberg
  • Patent number: 10350145
    Abstract: A system comprising a nasogastric tube comprising a nasogastric location element, a feeding mechanism, a suction mechanism configured to sealingly draw an inner wall of an esophagus against said nasogastric tube, and a gastric decompression mechanism.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: July 16, 2019
    Assignee: ENVIZION MEDICAL LTD.
    Inventors: Doron Besser, Guy Ben Ezra
  • Patent number: 10285934
    Abstract: A method of administering a drug into the brain of a mammal (human or nonhuman) is described. In this method, a magneto-electric nanoparticle (MENP) and a drug are injected into the blood stream of a mammal. The MENP attaches to the blood-brain barrier (BBB) and a non-alternating electric or magnetic field is applied. In an alternative, the non-alternating field could be replaced by a slowly alternating field so as to avoid localized heating. The step of applying an electric or magnetic field causes an increase in the permeability of the BBB to the drug so that the drug passes into the brain while the MENP remains attached to the BBB.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: May 14, 2019
    Assignee: Battelle Memorial Institute
    Inventors: Gaurav Sharma, Chad Bouton
  • Patent number: 10173062
    Abstract: Implanted pulse generators with reduced power consumption via signal strength-duration characteristics, and associated systems and methods are disclosed. A representative method for treating a patient in accordance with the disclosed technology includes receiving an input corresponding to an available voltage for an implanted medical device and identifying a signal delivery parameter value of an electrical signal based on a correlation between values of the signal delivery parameter and signal deliver amplitudes. The signal deliver parameter can include at least one of pulse width or duty cycle. The method can further include delivering an electrical therapy signal to the patient at the identified signal delivery parameter value using a voltage within a margin of the available voltage.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: January 8, 2019
    Assignee: Nevro Corp.
    Inventor: Jon Parker
  • Patent number: 10029094
    Abstract: A method for treating neural deficits resulting from multiple sclerosis, involving assessing a subject's motor, sensory, cognitive, or emotional deficits caused by multiple sclerosis; selecting a rehabilitative task based said deficits; determining the subject's acceptable performance threshold for the rehabilitative task; and providing a paired training therapy. The paired training therapy comprises having the subject to perform a trial of the rehabilitative task; classifying the subject's performance on the trial as either acceptable or unacceptable, wherein an acceptable performance is performance at or above the subject's acceptable performance threshold, and an unacceptable performance is performance below the subject's acceptable performance threshold; and reinforcing acceptable performance by selectively stimulating the subject's vagus nerve after completion of the acceptable performance.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: July 24, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michael P. Kilgard, Robert L. Rennaker, II
  • Patent number: 9974546
    Abstract: A guide and remote traction system for mini-invasive surgery in a body cavity that is easily positioned and hooked and causes lower injury, comprising: at least one detachable surgical endoclamp (10) with hooking means (11, 12), assembled with an introduction guide (20) and at an initially open position; and at a naturally closed position when detached from said introduction guide (20) by a detachment mechanism; said endoclamp (10) comprising a portion of ferromagnetic material at the end opposed to said hooking means (11, 12); a cylindrically-shaped introduction guide (20) assembled with said detachable surgical endoclamp (10), said introduction guide (20) comprising a mechanism to detach said endoclamp (10); and at least one remote traction means (30) for said endoclamp (10), acting through the application of an electromagnetic field over the ferromagnetic portion of said endoclamp (10).
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: May 22, 2018
    Assignee: Levita Magnetics International Corp.
    Inventors: Manuel Rodriguez Fernandez, Alberto Rodriguez Navarro
  • Patent number: 9955889
    Abstract: Cardiac catheterization is facilitated by generating first and second electroanatomic maps of a heart of a subject and designating common spatial locations that correspond to first electrical events on the first electroanatomic map and second electrical events on the second electroanatomic map. The common spatial locations of the first electroanatomic map and the second electroanatomic map are aligned to establish an aligned map, and using the location data on the aligned map to guide a probe to a point of interest.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: May 1, 2018
    Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
    Inventors: Roy Urman, Ronen Krupnik, Liron Shmuel Mizrahi
  • Patent number: 9931429
    Abstract: A particle includes a ferromagnetic material, a radiopaque material, and/or an MRI-visible material.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: April 3, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Robert F. Rioux, Thomas V. Casey, II, Janel Lanphere
  • Patent number: 9855164
    Abstract: Methods and devices comprised of a collapsible insert member and shaping member for treating obstructive sleep apnea are described. The insert member is placed in the tongue or other tissue forming the airway of the patient and has a lumen to accommodate the shaping member. The shaping member is inserted into the insert member by the patient just prior to sleep and removed upon waking. A variety of shaping members are available to treat patients on an individual basis, i.e., to match their particular anatomic condition that is causing their apnea or snoring. The shaping member can be made from nitinol, stainless steel, or any other known biocompatible implant material capable of providing a change in the tissue response to stress.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: January 2, 2018
    Assignee: Ethicon, Inc.
    Inventors: Kevin Weadock, Robert A. Rousseau
  • Patent number: 9844391
    Abstract: A guide and remote traction system for mini-invasive surgery in a body cavity that is easily positioned and hooked and causes lower injury, comprising: at least one detachable surgical endoclamp (10) with hooking means (11, 12), assembled with an introduction guide (20) and at an initially open position; and at a naturally closed position when detached from said introduction guide (20) by a detachment mechanism; said endoclamp (10) comprising a portion of ferromagnetic material at the end opposed to said hooking means (11, 12); a cylindrically-shaped introduction guide (20) assembled with said detachable surgical endoclamp (10), said introduction guide (20) comprising a mechanism to detach said endoclamp (10); and at least one remote traction means (30) for said endoclamp (10), acting through the application of an electromagnetic field over the ferromagnetic portion of said endoclamp (10).
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: December 19, 2017
    Assignee: Levita Magnetics International Corp.
    Inventors: Manuel Rodriguez Fernandez, Alberto Rodriguez Navarro
  • Patent number: 9755231
    Abstract: Provided are a method of preparing iron oxide nanoparticles, iron oxide nanoparticles prepared thereby, and an anode material including the iron oxide nanoparticles.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: September 5, 2017
    Assignee: LG Chem, Ltd.
    Inventors: Myung Ki Lee, Sung Bin Park, Sung Joong Kang, Wang Mo Jung
  • Patent number: 9669200
    Abstract: Systems and methods of localizing or delivery cells, biologics and/or drugs to a specific target area to treat pelvic health disorders are provided. A treatment composition including cells, biologics and/or drugs are associated with magnetic particulates, and the positioning of these materials is facilitated through use of a magnetic field-generating device that is configured to be placed on or into a pelvic anatomical structure. Certain embodiments directed to the treatment of ED in male patients can include a cell based therapy system.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: June 6, 2017
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Natalie Ann Borgos, Tania M. Schroeder, David J. Yonce, Robert E. Lund, Suranajan Roychowdhury
  • Patent number: 9669232
    Abstract: Magneto-electric nanoparticles in a subject interact with an external magnetic field to cause stimulation of neural networks in the subject. Electric signals in the neural network are coupled to magnetic dipoles induced in the nanoparticles to cause changes in electric pulse sequences of the subject's brain.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: June 6, 2017
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Sakhrat Khizroev, Madhavan P. N. Nair
  • Patent number: 9656058
    Abstract: Techniques for insertion of a cochlear implant include using a rotatable manipulator magnet to steer the tip of the cochlear implant. Steering can use magnetic torque and/or force between the manipulator magnet and a magnetic element coupled to the tip of the cochlear implant to control bending of the cochlear implant.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: May 23, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Jacob J. Abbott, James R. Clark, Frank M. Warren
  • Patent number: 9561158
    Abstract: An illuminating bridle catheter installation system includes a flexible member having a leading end and a trailing end with a first magnet coupled to the leading end of the flexible member, and a retrieving member having a leading end and a trailing end with two non-contacting second magnets coupled to the leading end of the retrieving member. An illuminating member is coupled to one of the flexible member or the retrieving member and the illuminating member is coupled to an electronic circuit having a switch that allows the illuminating member to be illuminated when the first magnet meets the second magnets.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 7, 2017
    Assignee: APPLIED MEDICAL TECHNOLOGY, INC.
    Inventor: George J. Picha
  • Patent number: 9510959
    Abstract: A device for use in reducing or preventing the occurrence of restenosis following procedures such as PTCA, in which a stent is used to hold a bodily lumen open. The device comprises a two layered stent, one lying within the other. Both stent layers have an open weave structure, such that they can expand to the correct dimensions after implantation. The outer stent layer is static and grips the inner wall of the lumen in which it is deployed in the usual manner. The inner layer stent is constructed such that it can be vibrated relative to the outer static stent layer. The inner layer stent may be made of a material which can be vibrated from an external source, such as a ferromagnetic material. This vibration prevents restenosis of the treated lumen. Alternatively, a vibrator, such as a piezoelectric device, can be installed on the inner stent layer.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: December 6, 2016
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Moshe Shoham, Amit Reches, Lucy Leshansky, Michael Groskop, Shachar Millis, Yishai Pentanovich
  • Patent number: 9427466
    Abstract: Methods for reducing the growth of breast cancer cells in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold or magnetic nanoparticles. The nanoparticles can have a cancer drug attached, such as an antibody-based cancer drug.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: August 30, 2016
    Assignee: Academia Sinica
    Inventors: Olga K. Kosheleva, Peter Lai, Nelson G. Chen, Michael Hsiao, Chung-Hsuan Chen
  • Patent number: 9421015
    Abstract: A system and method for endoscopically forming an anastomosis between two naturally adjacent points in the digestive tract. The system and method utilizes elongate magnetic devices that, when connected across a tissue boundary, necrose tissue until an anastomosis forms and the devices are passed naturally. Despite the elongate shape of the devices, the resulting anastomosis is substantially round. As such, round anastomoses can be formed having increased diameters merely by increasing the lengths of the devices, obviating the need for wider endoscopes.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: August 23, 2016
    Inventors: Michel Gagner, David J. Blaeser, Todd A. Krinke, Philip J. Haarstad
  • Patent number: 9302104
    Abstract: Devices, systems, and methods for automated optimization of muscle stimulation energy. In some embodiments the disclosure optimizes stimulation parameters and/or stimulation location.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: April 5, 2016
    Assignee: NIVEUS MEDICAL, INC.
    Inventor: Brian J. Fahey
  • Patent number: 9272158
    Abstract: Magneto-electric nanoparticles in a subject interact with an external magnetic field to cause stimulation of neural networks in the subject. Electric signals in the neural network are coupled to magnetic dipoles induced in the nanoparticles to cause changes in electric pulse sequences of the subject's brain.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: March 1, 2016
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Sakhrat Khizroev, Madhavan P. N. Nair
  • Patent number: 9233163
    Abstract: A prodrug according to formula (I) wherein R2 is a residue of a drug, said drug having a hydroxyl group by which the COOR2 group is formed; Z is O or NH; m is 0 or 1; and R3 is an organic moiety comprising a lipophilic group or a residue of a polymer, provided that Z is 0 if the polymer is carboxymethyl dextran. A system includes a plurality of magnetic nanoparticles including a prodrug as described above, a stent and a source of uniform magnetic field capable of producing temporary magnetization of the stent and/or the magnetic nanoparticles. A method of treating a medical condition with a drug includes administering to a patient in need of the drug a prodrug as described above, the prodrug being capable of releasing the drug in the patient after the administration step.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: January 12, 2016
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Ivan Alferiev, Michael Chorny, Robert J. Levy
  • Patent number: 9211422
    Abstract: The system and methods of the invention partially shields the radiation dose to the skin and/or other anatomical organs by using magnetically responsive material that blocks radiation, which may be fine grains of iron or other ferrous powder for example. The powder is typically injected into an IB applicator, along with inflating saline solution in case of MSB, when a skin spacing problem is encountered, or there is a risk of high doses being delivered to the critical organs surrounding a lumpectomy cavity, for example. A slight magnetic field of predetermined configuration will be applied externally to arrange the shielding material internally under the segment of surface of the IB applicator where the skin spacing is typically less than 7 mm, thereby protecting the skin from radiation damage. Monte Carlo studies to develop parameterizations for treatment planning with the IB applicator utilizing the suggested shielding material is also provided.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: December 15, 2015
    Assignee: Hampton University
    Inventors: Cynthia E. Keppel, Vahagn R. Nazaryan
  • Patent number: 9173714
    Abstract: An anchoring device for use within a body cavity during a surgical procedure is disclosed. The anchoring device includes an external assembly, an internal assembly, a controller, and a module. The external assembly has a first magnetic component. The internal assembly has a second magnetic component. The internal assembly is sized to be placed inside of the body cavity. The electrical current is connected with one of the first and the second magnetic component to produce a magnetic field about the connected magnetic component to approximate the internal and external assemblies. The module determines a parameter and is in communication with a controller. The controller controls the electrical current in response to the parameter.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: November 3, 2015
    Assignee: Covidien LP
    Inventor: Frank J. Viola
  • Patent number: 9174045
    Abstract: Transcutaneous electrical and magnetic nerve stimulation devices and methods generate energy that is delivered noninvasively to selected nerve fibers within the patient to treat lower urinary tract disorders. The disorders comprise overactive bladder, urge incontinence, stress, incontinence, urge frequency, non-obstructive urinary retention and interstitial cystitis/painful bladder syndrome. In preferred embodiments, a posterior tibial nerve of a patient is stimulated non-invasively to treat bladder disorders.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: November 3, 2015
    Assignee: Electrocore, LLC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 9161856
    Abstract: Devices, systems, and methods employ at least one ferromagnetic structure sized and configured for placement in a tissue region. A component is attached to the structure to stabilize its placement in the tissue region. An anchoring structure holds the component in a state of tension. The anchoring structure can, e.g., take the from of an anchoring body that expands in situ. The anchoring structure can be adjustable for adjusting the state of tension. The component can be elastic, to deflect under load in a prescribed manner and to recover an initial shape when unloaded.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: October 20, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Lionel M. Nelson, Octavian Iancea, Brian K. McCollum, Andres D. Tomas
  • Patent number: 9108035
    Abstract: Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: August 18, 2015
    Assignees: University of Maryland, College Park, The United States of America as represented by the Secretary, Department of Health and Human Services, National Institutes of Health
    Inventors: Benjamin Shapiro, Michael R. Emmert-Buck
  • Patent number: 9084877
    Abstract: A treatment system includes a magnetic targeting catheter and a plurality of MNP. The MNP may include one or more magnetic field-responsive agents and one or more therapeutic agents. The catheter may include an inner shaft having at least one lumen and a fluid delivery balloon adapted to administer a fluid from the inner shaft into a space surrounding the catheter. An expandable mesh formed of a magnetizable material may surround the fluid delivery balloon. The catheter may further include one or more occlusion balloons for controlling blood flow through a vessel in which the catheter is placed. A method of treating a medical condition may include advancing a magnetic targeting catheter to a site, deploying an expandable mesh connected to the catheter, applying a magnetic field to the mesh and depositing a plurality of MNP or cells loaded with MNP near the mesh.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: July 21, 2015
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Michael Chorny, Ilia Fishbein
  • Patent number: 9066780
    Abstract: A medical device includes an outer shell defining a cavity, wherein the shell is movable between a deformed and unstressed state, a magnet disposed within the cavity, and a filler material carried within the cavity conforming to the interior shape of the shell in the unstressed state and being capable of holding its shape in the deformed state. The filler material converts from the deformed state to the unstressed state at a temperature not greater than human body temperature.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: June 30, 2015
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventor: Jan Weber
  • Publication number: 20150141767
    Abstract: Provided are devices and methods capable of interfacing with biological tissues, such as organs like the heart, in real-time and using techniques which provide the ability to monitor and control complex physical, chemical, biochemical and thermal properties of the tissues as a function of time. The described devices and methods utilize micro scale sensors and actuators to spatially monitor and control a variety of physical, chemical and biological tissue parameters, such as temperature, pH, spatial position, force, pressure, electrophysiology and to spatially provide a variety of stimuli, such as heat, light, voltage and current.
    Type: Application
    Filed: October 2, 2014
    Publication date: May 21, 2015
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventors: John A. ROGERS, Igor EFIMOV, Sarah GUTBROD, Lizhi XU, Andrew BONIFAS, Richard Chad WEBB, Ahyeon KOH
  • Publication number: 20150141735
    Abstract: The present invention relates to a method and device for the selective destruction of cells that with uncontrolled proliferation in an animal organism, with minimum damage to the surrounding tissue thereby and without needing to perform any kind of surgical operation on the patient: the method consists of the detection of the tumorous area (1) and the sequential and alternate application of at least two alternating magnetic fields with different directions to the treatment area or application until achieving the heating and destruction of the cells. The device used is, therefore, comprised of at least two electromagnets (11, 12) or at least two pairs of electromagnets (11-11?, 12-12?) all being located around the perimeter of a hypothetical circumference or sphere, with the electromagnets in opposing pairs where each opposing pair generates an electromagnetic field in one direction and orientation.
    Type: Application
    Filed: May 22, 2013
    Publication date: May 21, 2015
    Applicant: INVESTIGACIONES, DESARROLLOS INNOVACIONES TAT IBERICA, S.L.
    Inventors: Ricardo Díaz Valle, Sonia Tejada Solís, Juan Manuel Sepúlveda Sánchez, Virginia Rodríguez González, Ana Castaños Cantos, Marina Torres Gómez, Ildefonso Del Campo Sánchez, Vicente Torres Junco
  • Patent number: 9028829
    Abstract: Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Therapeutic particles can comprise antioxidant enzymes, and can be targeted to cells to protect the cells from oxidative damage.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: May 12, 2015
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Michael Chorny, Vladimir Muzykantov, Elizabeth Hood
  • Patent number: 9011310
    Abstract: Effective systems and methods for improving neural communication impairment of a vertebrate being and affecting motor activity of a peripheral body part including a first signal-providing component configured to provide pulsed peripheral stimulation signals at the peripheral body part, a second signal-providing component configured to provide a pulsed motor cortex stimulation signal to a motor cortex area, a substantially DC signal-providing component configured to provide direct current spinal stimulation signal at a neural spinal junction and a controller component configured to control timing of the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: April 21, 2015
    Assignee: The Research Foundation of the City University of New York
    Inventor: Zaghloul Ahmed
  • Publication number: 20150099919
    Abstract: A system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator is provided. In one embodiment, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.
    Type: Application
    Filed: May 2, 2014
    Publication date: April 9, 2015
    Applicant: Pulse Therapeutics, Inc.
    Inventor: Francis M. Creighton
  • Publication number: 20150094521
    Abstract: There is provided in accordance with an exemplary embodiment of the invention a method of osteointegration of an implant into surrounding jaw-bone, the method comprising: applying a magnetic field around an implant, the magnetic field produced around the implant to a jaw-bone depth of up to at least about 7 mm, the magnetic field having a magnetic flux density of about 0.05-0.5 mT at up to at least about 2 mm from a surface of the implant, the magnetic field produced by a coil within the implant. A device adapted for insertion into a jawbone implant and for producing the magnetic field for bone enhancement of surrounding jawbone is also described.
    Type: Application
    Filed: May 2, 2013
    Publication date: April 2, 2015
    Inventors: Moshe Neuman, Roni Daffan, Joseph Shechter
  • Publication number: 20150065821
    Abstract: Functionalized particles in the blood are able to selectively bind to targets in the blood that have adverse health effects. The binding of the particles to the targets allows the targets to be selectively modified or destroyed by energy from outside the body such that the adverse health effects are reduced or eliminated. The energy is generated by a wearable device which is able to direct the energy into the subsurface vasculature of the wearer of the wearable device. Further, one or more of the functionalized particles may be magnetic, allowing a magnetic field generated by the wearable device and directed into the subsurface vasculature to concentrate the bound targets in a lumen of the subsurface vasculature proximate to the wearable device.
    Type: Application
    Filed: September 5, 2013
    Publication date: March 5, 2015
    Applicant: Google Inc.
    Inventor: Andrew Jason Conrad
  • Patent number: 8968171
    Abstract: The Energy Field and Target Correlation System automatically correlates the characteristics of target particles and a living organism to compute the characteristics of an energy field that is applied to a living organism to activate the target particles which are bound to or consumed or taken up by invasive agents in the living organism to produce detectable effects which can be used to image and treat the invasive agents. The energy field must be crafted to properly control the response and localize the extent of the illumination. The System automatically selects a set of energy field characteristics, including: field type, frequency, field strength, duration, field modulation, repetition frequency, beam size, and focal point. The determined energy field characteristics then are used to activate field generators to generate the desired energy field.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Endomagnetics Limited
    Inventors: Daniel B. McKenna, Karl M. Frantz, Marvin A. Ross, Andrew C. Updegrave, Michael E. Susedik
  • Patent number: 8951547
    Abstract: An ocular drug delivery system comprising a photocaged drug comprising a therapeutic agent that is rendered biologically inactive by being coupled to a protective ligand or caging group by a photocleavable bond, with the therapeutic agent being capable of being activated and/or released in response to a predetermined wavelength and/or intensity of light which breaks the photocleavable bond.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: February 10, 2015
    Assignee: Lumemed Limited
    Inventor: Alan Whitmore
  • Publication number: 20150037249
    Abstract: The present invention relates to methods for delivering at least one agent unto or into a biological sample or a biological subject. The methods comprise a step of contacting the biological sample or subject with a payload-carrying nanostructure. The nanostructure can be a porous low density nanostructure.
    Type: Application
    Filed: February 19, 2013
    Publication date: February 5, 2015
    Inventor: Aihua Fu
  • Patent number: 8931490
    Abstract: The present invention relates to signaling mechanisms that transduce magnetic inputs into physiological cellular outputs. More particularly, the present invention relates to systems and methods for non-invasively controlling cellular signaling functions and behaviors by harnessing receptor-mediated and intracellular molecular-mediated signal transduction using nanomagnetic cellular switches.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: January 13, 2015
    Assignee: Children's Medical Center Corporation
    Inventors: Donald E. Ingber, Robert J. Mannix, Sanjay Kumar
  • Patent number: 8926491
    Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: January 6, 2015
    Assignee: Pulse Therapeutics, Inc.
    Inventor: Francis M. Creighton
  • Publication number: 20140364678
    Abstract: A neuro-stimulation system employs a includes a stimulator which may include electrode devices and/or vibration elements. A controller may be employed to drive the stimulating elements with an electrical signal. In response to the electrical signal, the stimulating elements deliver electrical and/or mechanical stimulation to the body part. The stimulation may be an aperiodic stimulation and/or may be a subthreshold stimulation. In one embodiment, the stimulator is disposable and the processor determines usage of the stimulator and ensures that the stimulator is limited to a certain amount of use. Neuro-stimulation systems may be applied to sensory cells of body parts during movement of the body parts to induce neuroplastic changes. Such movement may involve a variety of therapeutic applications, e.g. in stroke patient therapy.
    Type: Application
    Filed: April 10, 2014
    Publication date: December 11, 2014
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Jason D. Harry, James B. Niemi, Scott Kellogg, Susan D'Andrea
  • Publication number: 20140357933
    Abstract: An implantable neural stimulation device includes a magnetic coil specifically dimensioned to be implantable inside the tissue and structured to generate, in the vicinity of the target tissue adjacent to which such coils is disposed in operation, magnetic field the strength of which is substantially the same as the strength of magnetic field generated in such tissue during the conventional TMS procedure. The modulation of orientation of microcoil modulates the activation of targeted neuronal tissue.
    Type: Application
    Filed: June 3, 2014
    Publication date: December 4, 2014
    Inventors: Seungwoo Lee, Giorgio Bonmassar, Shelley Fried
  • Patent number: 8900229
    Abstract: A medical probe includes an insertion tube, having a longitudinal axis and having a distal end. A distal tip is disposed at the distal end of the insertion tube and is configured to be brought into contact with a body tissue. A joint couples the distal tip to the distal end of the insertion tube. A joint sensor, contained within the probe, senses a position of the distal tip relative to the distal end of the insertion tube. The joint sensor includes first and second subassemblies, which are disposed within the probe on opposite, respective sides of the joint and each include one or more magnetic transducers.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: December 2, 2014
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Assaf Govari, Yaron Ephrath, Ariel Garcia, Andres Claudio Altmann