Abstract: The present invention relates to the in vivo stimulation of cellular material. In particular, the present invention relates to a method for stimulating cells and tissue in vivo comprising the step of applying to said cells and tissue an electrobiomimetic stimulus, wherein the growth characteristics of said cells and tissue are enhanced as compared to cells and tissue not receiving said stimulus.

Abstract: Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.

Abstract: A method of providing an implantable stimulation system to achieve chronic or permanent electrical stimulation of acupuncture points to treat a variety of chronic disorders.

Abstract: There is provided a stimulus generation apparatus including a stimulus generation section which provides a stimulus for promoting fat burning for fat or a satiety center inside a body cavity.

Abstract: An electrical system having an underlying structure resembling the double helix most commonly associated with DNA is used to produce useful electromagnetic fields for health applications and/or medical applications.

Abstract: An apparatus and method for electromagnetic treatment of plants, animals, and humans comprising: configuring at least one waveform according to a mathematical model having at least one waveform parameter, said at least one waveform to be coupled to a target pathway structure; choosing a value of said at least one waveform parameter so that said at least waveform is configured to be detectable in said target pathway structure above background activity in said target pathway structure; generating an electromagnetic signal from said configured at least one waveform; and coupling said electromagnetic signal to said target pathway structure using a coupling device.

Abstract: Techniques for applying torque to microscopic paramagnetic structures in a body includes exposing a body simultaneously to a first magnetic field oscillating at a first frequency in a first direction and a different second magnetic field oscillating at a second frequency in a second direction. The body includes a plurality of microscopic paramagnetic structures for which magnetic susceptibility to the first magnetic field is different from magnetic susceptibility to the second magnetic field. Such techniques are effective for ameliorating a symptom of a disease in an animal in which disease agents or diseased cells selectively include microscopic paramagnetic structures, including malaria.

Abstract: An implantable neurostimulator system for treating pain includes scheduled and responsive therapy capabilities including responsive stimulation applied to the brain and peripheral sections of the nervous system. Methods for treating chronic nociceptive, neuropathic, and psychogenic pain employ an inventive system to advantageously reduce multiple symptoms and components of pain and to address underlying causes of pain.

Abstract: A system and method for manipulating devices, such as a medical implant arranged within a subject, is provided. For non-invasive manipulation of a medical implant, a subject having a non-ferromagnetic medical implant arranged therein is arranged within a system having a static magnetic field and a plurality of adjustable magnetic fields. The non-ferromagnetic medical implant includes at least one cavity and at least one ferromagnetic or ferrimagnetic material arranged within the at least one cavity. The plurality of adjustable magnetic fields of the system are controlled to induce forces on the at least one ferromagnetic or ferrimagnetic material arranged within the at least one cavity to thereby apply the induced forces to the non-ferromagnetic medical implant to effectuate a non-invasive, in vivo manipulation of the non-ferromagnetic medical implant. Other implementations include the manipulation devices such as robotic medical systems, using magnetic fields to drive the robotic medical system.

Abstract: A composition used for thermotherapy includes a carrier structure and a plurality of metal particles. The carrier structure includes a lipid layer, a positive charged polymer and a surface active polymer. The positive charged polymer and the surface active polymer are dispersed on the lipid layer by non-covalent bonding. The metal particles are encapsulated in the carrier structure. A producing method of the composition used for thermotherapy and a method for using the composition in cancer treatment are also disclosed.

Abstract: Disclosed are nanoparticle compositions comprising paramagnetic particles, radiolabels, fluorophores, and/or positron emission tomography agents encapsulated within a biocompatible vehicle. In addition, methods of multi-modal diagnostic imaging and treating diseased tissues are disclosed, wherein the methods comprises administering a nanoparticle composition to a subject in which the nanoparticle composition comprises paramagnetic particles, radiolabels, fluorophores, and positron emission tomography agents encapsulated within a biocompatible vehicle.

Abstract: Disclosed are a method for enhancing contrast of magnetic resonance imaging and a method for treating tumor.

Abstract: Magneto-electric nanoparticles in a subject interact with an external magnetic field to cause stimulation of neural networks in the subject. Electric signals in the neural network are coupled to magnetic dipoles induced in the nanoparticles to cause changes in electric pulse sequences of the subject's brain.

Abstract: Magnetic structures develop a magnetic force between a tongue and a posterior pharyngeal wall to stabilize an orientation of the tongue.

Abstract: The present invention provides a system and method for neurological treatment. The system of the invention includes a neurological stimulation (NS) modality that delivers neurological stimulation to a first brain region and a cognitive training (CT) that delivers CT to a second brain region, where activation of the CT modality occurs at a predetermined time relative to the activation period of the NS modality. In one embodiment, the NS and CT are interlaced. The first and second brain regions may be the same brain regions or different brain regions. The invention may be used, for example, in the treatment of dementia, neurological conditions or psychiatric conditions.

Abstract: Minimally invasive delivery with intercellular and/or intracellular localization of nano- and micro-particle solar cells within and among excitable biological cells to controllably regulate membrane polarization and enhance function of such cells. The cells include retinal and other excitable cells, and normally non-excitable cells in proximity to partially or wholly non-functional excitable cells.

Abstract: A method and apparatus for altering the charge distribution upon living membranes with functional stabilizational of the membrane physical electrical integrity further comprising a method for using submicroscopic, quadripolar, circular, center charged, energy balanced magnetic device in a four (4) magnet array of alternating polarity in which the magnetic poles are separated only by a distance which will allow a magnetic sphere of influence on all adjacent poles to suppress the firing of action potentials of mammalian sensory neurons. The method and apparatus further provides a static magnetic device for production of a magnetic field for treatment of various disorders.

Abstract: Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.

Abstract: Disclosed embodiments provide an apparatus and method for brushing plaques from vessels by exposing intraluminal nanoparticles to changing magnetic gradients.

Abstract: An ocular drug delivery system comprising a photocaged drug comprising a therapeutic agent that is rendered biologically inactive by being coupled to a protective ligand or caging group by a photocleavable bond, with the therapeutic agent being capable of being activated and/or released in response to a predetermined wavelength and/or intensity of light which breaks the photocleavable bond.

Abstract: A system for controlling the location of a therapeutic agent administered to a mammal is provided. The system employs a device that is capable of generating a magnetic field and a therapeutic agent labeled with a magnetically responsive moiety. Methods which employ the device and the therapeutic agent are also provided.

Abstract: The present invention relates to aerosols containing magnetic particles, wherein the aerosols comprise magnetic particles and a pharmaceutical active agent. The invention furthermore relates to the use of such aerosols containing magnetic particles for directed magnetic field-guided transfer of the active agents contained therein in aerosol therapy.

Abstract: Nanoparticle-sized magnetic absorption enhancers (MAEs) that exhibit a controlled response to a magnetic field, including a controlled mechanical response and inductive thermal response. The MAEs have a magnetic material that exhibits the inductive thermal response to the magnetic field and is embedded in a coating, such that the MAE conforms to a particular shape, e.g., a hemisphere, a dome or a shell, that is chosen to produce the desired controlled mechanical response of the entire MAE to the magnetic field. A targeting moiety for specifically binding the MAE to a pathogen target is also provided. The MAEs are preferably bound by a flexible linker to promote the desired mechanical response, which includes interactions between MAEs that are not bound to their pathogen target for the purpose of forming spheres, spherical shells, or generally spherical dimers.

Abstract: Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.

Abstract: Methods, devices, and kits comprising a magnetic system for automation of blinking, or to provide temporary or permanent assistance with opening or closure of the eyelids to treat disorders of the eyelids, including lagophthalmos and ptosis.

Abstract: Described herein are electromagnetic treatment devices for treatment of tissue. In particular, described herein are lightweight, wearable, low-energy variations that are specifically configured to specifically and sufficiently apply energy within a specific bandpass of frequencies of a target biological pathway, such as the binding of Calcium to Calmodulin, and thereby regulate the pathway. Methods and systems for treating biological tissue are also described.

Abstract: A magnet delivery system for forming an anastomosis that comprises a wire guide; a catheter having a delivery portion for advancement into a visceral space, the delivery portion having a lumen extending at least partially therethrough and an expandable balloon for dilation and a lumen extending therethrough, a first port and a second port in communication with the lumen through which the wire guide is disposed; a magnet comprising a lumen therethrough wherein the magnet is removably secured to the delivery portion of the catheter between the first and second ports by disposing the wire guide through the lumen of the magnet, the first port and the second port.

Abstract: A treatment system includes a magnetic targeting catheter and a plurality of MNP. The MNP may include one or more magnetic field-responsive agents and one or more therapeutic agents. The catheter may include an inner shaft having at least one lumen and a fluid delivery balloon adapted to administer a fluid from the inner shaft into a space surrounding the catheter. An expandable mesh formed of a magnetizable material may surround the fluid delivery balloon. The catheter may further include one or more occlusion balloons for controlling blood flow through a vessel in which the catheter is placed. A method of treating a medical condition may include advancing a magnetic targeting catheter to a site, deploying an expandable mesh connected to the catheter, applying a magnetic field to the mesh and depositing a plurality of MNP or cells loaded with MNP near the mesh.

Abstract: The invention describes a system for the magnetic attraction of objects, which comprises a device with a magnetic element and at least one object having magnetic particles.

Abstract: Various embodiments of spacer apparatuses, and transport and/or storage apparatuses, for use with magnetic platforms configured to be magnetically coupled to a medical device within a body cavity of a patient.

Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.

Abstract: A device for manipulating a magnetic coupling force across tissue in response to a monitored coupling force is described. The device includes a magnetic field source assembly that includes at least one fixed magnet and a rotatable magnet positioned within a cavity defined by the fixed magnet that provide an external magnetic field source for providing a magnetic field across tissue. An actuation assembly is operatively connected to the magnetic field force assembly. A sensor is provided that senses a magnetic coupling force and communicates changes therein to a controller which directs the accuation assembly to adjust the speed of rotation of the rotatable magnet in response to the sensed changes in magnetic coupling force to effect a change of magnetic flux generated by the rotatable magnet.

Abstract: The present invention provides derivatized magnetic nanoparticles, methods for making such nanoparticles, and methods for their use.

Abstract: A medical probe includes an insertion tube, having a longitudinal axis and having a distal end. A distal tip is disposed at the distal end of the insertion tube and is configured to be brought into contact with a body tissue. A joint couples the distal tip to the distal end of the insertion tube. A joint sensor, contained within the probe, senses a position of the distal tip relative to the distal end of the insertion tube. The joint sensor includes first and second subassemblies, which are disposed within the probe on opposite, respective sides of the joint and each include one or more magnetic transducers.

Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.

Abstract: The invention provides solutions to the problem connected with detached eye retinas and to methods that can promote the healing of the repaired retina. Instead of injecting gas bubbles or silicone oil into the eyeball, the invention proposes to inject magnetic particles inside the eye and use external magnets to urge the magnetic particles to move against the repaired area of the retina, thus forcing the retina against the eyeball walls, thus promoting the healing. Optional eye movement sensors can optimize the distribution of the magnetic particles, to optimize the force holding the retina in place, thus optimizing the healing benefits of using the proposed system. The magnetic particles can be bio-inert and/or degradable. Other helpful devices are proposed as well to reduce the stresses on the patient's neck muscles in case he/she still needs to hold the head in a certain position for a long period of time.

Abstract: A system to induce hyperthermia in a selected portion of the body utilizes permanent magnets mounted on a variable speed motor. A conductive button is positioned at a location proximate the target tissue to be heated, such as a tumor. The magnetic rotor assembly is positioned at a selected distance from the conductive button and rotated at a desired frequency to produce a changing permanent magnetic field that induces an eddy current on the surface of the conductive button. A temperature sensor may be positioned near the conductive button as a feedback mechanism to a control circuit. At higher magnetic polarity frequencies, the conductive button may be implemented in the form of metallic nanoparticles. In this embodiment, the nanoparticles may include molecular elements that selectively bind with the target tissue and thereby accumulate at the target tissue prior to the introduction of the rotating magnetic field.

Abstract: This invention relates to a material for medical use that comprises biocompatible nanoparticles having superparamagnetic properties, where the superparamagnetic properties of said nanoparticles are used to localize their action on a determined space or tissue. In particular, said nanoparticles having superparamagnetic properties are composed of magnetite. The material according to the invention has various applications, both in surgical and in therapeutic treatments.

Abstract: A device that is implantable in the temporal bone for dispensing at least one component of a liquid product, comprising a catheter and means for moving the component along the catheter, wherein the product incorporates particles for transporting the component, the particles being movable under the effect of a magnetic field, wherein the catheter comprises portions for discharging the component from the catheter, the discharging portions being distributed along the catheter, and wherein the moving means comprise means for generating a magnetic field near each discharging portion so as to move the product from discharging portion to discharging portion, the field-generating means comprising windings that surround the discharging portions and that are connected to a control module designed to successively power at least some of the windings. A hearing aid, such as a cochlear implant, comprising an internal unit having an electrode holder provided with such a device.

Abstract: Certain example embodiments relate to techniques for using coherent electromagnetic (EM) waves to treat tumors and/or other growths. In certain example embodiments, a growth is imaged. Based on this image, a holographic plate is prepared. Coherent electromagnetic waves are then focused on the holographic plate so that a holographic image of the growth is formed on the actual growth. Magnetic particles may be injected at or proximate to the growth and captured in the EM field corresponding to the holographic image such that these injected particles are caused to congregate in and/or on the growth. In certain example embodiments, bombarding of the growth with the injected particles may help damage or destroy the tumor. In certain example embodiments, the particles, once attached to and/or embedded in the actual growth may be irradiated (e.g., using a microwave or other energy source) so as to further damage or destroy the growth.

Abstract: Systems and methods for magnetic control of an anesthetic or analgesic agent are disclosed. In an exemplary embodiment, the method includes delivering a fluidic agent to a spinal region of a subject. The fluidic agent includes an anesthetic and/or analgesic component and a magnetic component. The method also includes applying a magnetic field to an area proximate a target area of the spinal region such as to maintain the fluidic agent at the target area, move the fluidic agent towards the target area, or move the fluidic agent away from the target area.

Abstract: Lumen-traveling biological interface devices and associated methods and systems are described. Lumen-traveling biological interface devices capable of traveling within a body lumen may include a propelling mechanism to produce movement of the lumen-traveling device within the lumen, electrodes or other electromagnetic transducers for detecting biological signals and electrodes, coils or other electromagnetic transducers for delivering electromagnetic stimuli to stimulus responsive tissues. Lumen-traveling biological interface devices may also include additional components such as sensors, an active portion, and/or control circuitry.

Abstract: Magnetic gradients are used to transport Magnetic Nano Particles through a barrier, for example, the cribiform (also spelled “cribriform”) plate, which is a porous bony structure which separates the nasal cavity from the cranial vault. By utilizing a configuration of magnets (whether of the electromagnetic type or permanent magnets), MNPs can be propelled, pushed, pulled or otherwise manipulated in relation to an anatomical and/or physiological barrier, to position, re-position or maintain the position(s) of the MNPs.

Abstract: A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension.

Abstract: A medical device incorporating magnetic material is introduced into the body of a patient. A time varying magnetic field is generated externally of the patient's body and which is of sufficient strength to magnetically induce motion in the device, thereby causing the medical device to vibrate within the patient's body. The frequency and the amplitude of the magnetic field oscillations can be continuously varied to control the vibrations induced in the medical device.

Abstract: A minimally invasive method to eliminate circulating agents from an organism to prevent and treat diseases is disclosed. The method utilizes immunomagnetic methods to concentrate and localize disease-associated agents in a small region of the body. Subsequently, the complexes are removed from the body. Removal of disease-causing or disease-promoting agents (circulating tumor cells, bacteria, viruses and virus-infected cells, certain immune cells) would add a significant new option for intervention of disease progression and supplement other therapeutic options.

Abstract: A magnetic wire and medical procedure are provided. The wire is used to disrupt a clot within a body vessel. The wire includes a magnet that is positioned within the patient's body adjacent the clot. A magnetic driver is positioned outside the patient's body in proximity to the magnet. When the magnetic field of the magnetic driver is alternated, the wire moves within the body vessel to break up the clot.

Abstract: Solid lipid nanoparticles (SLNs) including elastin-like polypeptides, compositions comprising the SLNs, and uses thereof are provided.

Abstract: An integrated system and method for treatment of various diseases, including psychiatric, mental and brain disorders, which preferably combines personalized non-invasive neuronal brain stimulation together with appropriate personalized cognitive training, and which iteratively fine-tunes this treatment by monitoring specific cognitive and brain functions in response to the treatment. A novel brain stimulator device and method, Computerized Magnetic Photo-Electric Stimulator (CCMPES), is described, which integrates electromagnetic stimulation with laser stimulation to generate a magnetic photo-electric stimulation.

Abstract: Currently, no efficient, non-invasive methods exist for delivering drugs and/or other therapeutic agents to the interior of the eye to treat or prevent disease or injury. The present invention relates to a novel method that is suitable for the delivery of any therapeutic agent (suitably modified) to the interior of the eye without the need for the penetration of a needle into the eyeball. In a preferred embodiment, it involves an injection into a peripheral vein (or oral administration, or administration by some other eternal or parenteral route) of a solution of inert drug which is trapped in the eye by a magnetic field and activated by radiation once it is in position, so that the active agent is released only where it is needed and can have its therapeutic effect without affecting other tissues or organs. The inert drug may be composed of a biologically compatible magnetic nanoparticle chemically bound to a specially inactivated (caged) form of the drug to be delivered and to a luminescent marker.