Abstract: An imaging apparatus and method are provided. The probe for an imaging apparatus includes a manually manipulable proximal portion; a straight distal portion with a distal tip for locating at a site to define an observational field; and a curved portion between the proximal portion and the distal portion. The imaging method includes the steps of locating a distal tip of an imaging probe at a site to define an observational field; irradiating the observational field from the distal tip; and collecting a return signal at the distal tip; wherein the probe comprises a manually manipulable proximal portion. The apparatus and method provided herein are useful for various applications including but not limited to endomicroscopy and other microsurgical procedures performed under optical stereoscopic magnified visualization, such as neurosurgery, ENT/facial surgery and spinal surgery.

Abstract: The present invention provides, according to some embodiments, an in vivo imaging device, comprising a mount having at least one illumination source. The mount may be in electrical communication with the illumination source. The device may further include a circuit board and a contact clip for securing the mount to the circuit board and for providing electrical communication therebetween.

Abstract: A medical apparatus to support an endoscopic investigation that includes a housing with a base surface, a front surface and a rear surface, and a light source that is positioned in the housing to generate light to illuminate an object that is to be investigated with an endoscope. In addition the medical apparatus includes a coupling device to couple a proximal end of an endoscope on the medical apparatus and to transmit light from the medical apparatus to the endoscope. The medical apparatus includes a screen, which is positioned on the front surface of the housing to observe an image taken by means of the endoscope, where the front surface and rear surface are each inclined toward the rear at an angle between 5 and 15 degrees with respect to the base surface.

Abstract: A capsule endoscope includes an objective lens and a transparent dome that covers the object side of the objective lens, and the transparent dome has negative refracting power. In the capsule endoscope of the present invention, the center of curvature of the object-side surface of the transparent dome disagrees with the center of curvature of the objective-lens-side surface of the transparent dome to satisfy the following condition: Rb<L?Ra where Ra is the radius of curvature of the object-side surface of the transparent dome, Rb is the radius of curvature of the objective-lens-side surface of the transparent dome, and L is a distance from the vertex of the object-side surface of the transparent dome to the most object-side surface of the objective lens.

Abstract: An object of the present invention is to make it possible to closely examine a specific region by making most use of an advantage of a compound-eye capsule endoscope that picks up images of an interior of a body cavity forward and backward in a movement direction of a capsule casing. By disposing imaging devices of respective imaging blocks in a capsule casing while having a relationship between arrangement directions of the imaging devices, e.g., making upward and downward directions U and D coincident with each other, a correspondence/positional relationship between the images picked up by the imaging devices is clear when the specific region such as an affected part in the body cavity is to be observed using the respective images forward and backward in the movement direction, thereby facilitating close examination on the specific region using the both images.

Abstract: Herein are described components and use of an adjustable device delivery system including an adjustable internal door which allows angled deployment of medical devices, non-medical devices and electromagnetic radiation. In one embodiment, a slotted outer cannula is used with an inner drive cannula to guide the motion of an adjustable interior door that allows delivery of devices, such as medical instruments, at user-defined angles. The invention also provides device delivery systems that permit withdrawal of the adjustable device delivery system without disruption of a device placed therewith. The device delivery systems of the invention are provided having a steering system that permits exact control of the angle of the adjustable internal door while providing support against longitudinal forces.

Abstract: An Optical imaging catheter that balances optical aberrations and allows recording of high quality optical images while relaxing the requirement of a fluid occupying the space between the prism and the inner sheath of the catheter.

Abstract: An imaging assembly for use in a medical imaging device such as an endoscope or the like. In one embodiment, the imaging assembly includes a transparent distal cap that is shaped to receive an image sensor insert. The image sensor insert has a cooling channel that supplies a cooling liquid or gas to one or more illumination sources.

Abstract: An adapter device, which is configured to couple an endoscope with a medical appliance, such that the medical appliance is provided to generate light to illuminate an object to be investigated by an endoscope, includes an adapter body with a through-hole through which light generated by the medical appliance can be transmitted, and a fastening device to removably secure the adapter body on the medical appliance. The side of the adapter body that is to face the medical appliance is configured to be held form-locked in a predetermined angle position when the adapter body is secured on the medical appliance.

Abstract: An endoscope device is proposed for dealing with an erroneous operation of a surgeon. An endoscope device has an endoscope and a processor, wherein the endoscope has a switch unit and the processor has a CPU and an operating panel. In the event that the CPU of the processor detects that, of a first instruction signal transmitted from the switch unit and a second instruction signal transmitted from the operating panel, the instructions for performing the predetermined operation are not performed normally with one of the instruction signals, and instructions for performing an operation other than the predetermined operation is performed normally with the other instruction signal, the CPU stops the transmission of one of the instruction signals, and validates the operation content instructed by the other instruction signal.

Abstract: Provided are methods for detecting a disease or a condition in a subject, which disease or condition is known to be characterized by abnormal expression of an enzyme The present methods comprise contacting tissue of the subject with a substrate for the enzyme, the substrate chemiluminescing upon reaction with the enzyme, detecting chemiluminescence in the tissue, and, correlating the chemiluminescence to at least one of the presence or absence of the disease or condition in the subject, the stage of the disease or condition in the subject, or the response of the disease or condition in the subject to a therapy regimen The present invention permits sampling, diagnosis, and surveillance of conditions and diseases that are known to be characterized by abnormal expression of at least one enzyme.

Abstract: A method for reconstructing an ear canal from optical coherence tomography (OCT) scan data of an ear comprises extracting frame numbers and line numbers of interference intensities corresponding to one or more markers on an OCT scan guide, receiving reference frame numbers and lines numbers for one or more markers, determining a starting position and direction for the OCT ear scan from the ear scan marker frame and line numbers and the reference marker frame and line numbers, for each scan line, finding a pixel number of a maximum interference intensity value, and determining an offset distance of said pixel from said scan guide, and reconstructing a surface of the ear canal from the distance offset data.

Abstract: A low cost camera and radio frequency transmitter are detachably coupled to an endotracheal tube to obtain an image in real time of tissue at the distal end of the endotracheal tube. The image recorded by the camera is transmitted to a low cost radio frequency receiver nearby and conveyed to a video monitor to display the image. The use of a wireless transmission system avoids the presence of wires and cords that otherwise might become entangled and cause the endotracheal tube to be inadvertently repositioned or pulled out of the patient.

Abstract: An image pick-up unit inserted in the body picks up an image of the body, and transmits by radio the image to an extra-corporeal unit which is arranged outside the body. The image pick-up unit includes an image pick-up portion capturing an image, a data transmitting portion for transmitting the image obtained by the image pick-up portion to the extra-corporeal unit at a plurality of transmitting ratios, a characteristic amount detecting portion for detecting a predetermined amount of characteristics based on the image, and a determining portion for determining a valid image based on an output from the characteristic amount detecting portion. The data transmitting portion controls the data transmitting ratio in accordance with the determining result of the determining portion.

Abstract: A device, system and method for in-vivo analysis. An autonomous in-vivo device may include a magnet to detain at least a portion of a sample collected from a body lumen; a sensor to sense a property of the detained sample portion; and a transmitter to transmit data of the sensed property.

Abstract: An endoscope includes an illuminator that includes a light emitting surface for illuminating the inside of a living body, an objective optical system for forming an image of a specified object on one side of the objective optical system and illuminated by the illuminator, and a transparent cover that encompasses the illuminator and the one side of the objective optical system. The transparent cover includes an outer surface, and light emitted from the light emitting surface that is reflected by the outer surface satisfies a certain condition that helps prevent rearward dispersed light caused by scratches on, or substances adhering to, the external surface of the transparent cover from entering the entrance pupil of the objective optical system. The endoscope may also include a member for partially shielding the light emitted from the light emitting surface so as to limit the direction in which light is directed from said light emitting surface to the transparent cover.

Abstract: The present invention is directed to features and aspects of an in-vivo visualization system that comprises a catheter having an access port leading to an interior lumen through which an image transmission member is routed, and an endoscope having an access port leading to an interior lumen through which the catheter is routed. The catheter and endoscope are connected by an endoscope attachment device such that a handle of the catheter is mounted distal of the endoscope access port and the catheter access port is distal to the mounted position.

Abstract: A steerable imaging catheter is provided, including an elongated catheter tube, at least one steering cable extending along the catheter tube to control the movement of the distal end thereof, and a fiber optic cable extending along the catheter tube. The fiber optic cable transmits illumination light from its proximal end to its distal end and transmits an image from its distal end to its proximal end. In one embodiment, two or more steering cables are used, and the catheter tube is configured to have greater flexibility near its distal end than its proximal end so as to concentrate the movement (flexing) of the catheter tube at its distal end. The use of two or more steering cables, together with the catheter tube having varying flexibility, permit better control of the distal end of the catheter tube while reducing undue twisting of the remainder of the catheter tube.

Abstract: An endoscope attachment enables an endoscope to capture images of areas in front and at the sides of the endoscope. The endoscope attachment has a transparent attaching part which is used to attach the endoscope attachment to a probe of the endoscope and has two through-holes. A cylindrical transparent image capturing part is used to enable a camera of the probe to capture images and has a trumpet-shaped second mirror on the outer wall of the image capturing part and a wide angle lens with a hyperboloid in the image capturing part. A first mirror is formed at a part of the hyperboloid of the wide angle lens.

Abstract: A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

Abstract: There is provided a confocal scanning endoscope system, which is provided with a light source that emits light, a scanning unit that deflects the light emitted by the light source so that the light scans on a subject in two dimensions, an objective optical system that directs the light deflected by the scanning unit to the subject, an extraction unit that extracts only part of the light returning from a convergence point at which the light is converged by the objective optical system on an object side, an image formation unit configured to form an image based on the part of the light extracted by the extraction unit, and a display area adjustment unit configured to measure Encircled Energy of the part of the light extracted by the extraction unit and to adjust a display area of the image based on the measured Encircled Energy.

Abstract: An improved endoscopic device which is introduced into the intestinal tract of a living organism and which operates autonomously therein, adapted to obtain and store or transmit one or more types of data such as visual image data, laser autofluorescence data, or ultrasonic waveform data. In another aspect of the invention, an improved endoscopic device useful for implanting the aforementioned endoscopic smart probe is disclosed. In another aspect of the invention, apparatus for delivering agents including nanostructures, radionuclides, medication, and ligands is disclosed. In another aspect of the invention, apparatus for obtaining a biopsy of intestinal tissue is disclosed. In another aspect of the invention, apparatus for detecting the presence of one or more molecular species within the intestine is disclosed. Methods for inspecting and/or treating the interior regions of the intestinal tract using the aforementioned apparatus are also disclosed.

Abstract: An endoscope 100 includes a first light source 45 that emits white illumination light, a second light source 47 that emits narrow-band light and an imaging section that has an imaging device 21 having plural detection pixels and images a region to be observed. The imaging section is caused to output a captured image signal including both a return light component of the white illumination light from the region to be observed by and a return light component of the narrow-band light the white illumination light. From the captured image signal, the return light component of the narrow-band light is selectively extracted, and a brightness level of the extracted return light component of the narrow-band light is changed by changing a light amount of light emitted from the second light source 47.

Abstract: A illumination system for variable direction of view instruments is disclosed generally comprising an endoscope having a longitudinal axis and a variable view vector that pivots about a pivot axis angularly offset from the longitudinal axis. The view vector has an attendant viewing field that travels along a path as the view vector pivots, defining a viewing range. A source of illumination is arranged in a plane offset from the plane in which the view vector pivots and provides an annular, solid angle of illumination that covers the viewing range. In certain embodiments, the pivot axis is perpendicular to the longitudinal axis and the illumination plane is parallel to the pivot plane. In some embodiments, the source of illumination is a plurality of light emitting diodes arranged around the pivot axis.

Abstract: An encapsulated endoscope system in accordance with the present invention comprises: an encapsulated endoscope that rotates to develop a thrust; a controller that moves the encapsulated endoscope in an intended direction of advancement; an imaging unit incorporated in the encapsulated endoscope; and an image processing unit that receives image data sent from the imaging unit, and produces an image, which results from rotation of the received image data, according to the rotational phase of the encapsulated endoscope.

Abstract: Provided are a system and method for in vivo and in situ detection of body lumen conditions. The system comprises at least one interaction chamber for containing an endo-luminal sample, the interaction chamber comprising at least one indicator; at least one light source for illuminating the interaction chamber; and at least one optical detector for detecting in vivo optical changes occurring in the interaction chamber. The reaction between the indicator and sample may result in an optical change, which is detected and possibly imaged by the optical detector.

Abstract: An electronic endoscope apparatus includes a scope unit in which a color filter is provided. The scope unit further includes a filter information storage means for storing filter information showing the kind of the color filter provided in the scope unit. Further, a plurality of kinds of scope units, each of which has filter information showing a different kind of color filter from each other, can be selectively connected. The filter information stored in the filter storage means of the connected scope unit is obtained. Then, color space correction processing is performed, based on the filter information, on color image signals output from the plurality of kinds of scope units so that each of signals for display, produced from the color image signals, represents the same point in color space.

Abstract: The present invention provides an in-vivo imaging device comprising at least one imager and an associated optical system, at least the optical system located in an optical dome of the imaging device, the optical dome having a tip, the optical system comprising an optical lens, the optical system having a given effective focal length f, the optical lens being located at a distance D? from the tip; wherein D?/f?6.

Abstract: An endoscope insertion portion of the invention includes an outer surface formed between a plurality of observation windows oriented in a spouting direction of the air/water feeding portion, the outer surface being in the same plane as surfaces of the plurality of observation windows.

Abstract: A capsule medical apparatus including: a cylindrical capsule-shaped exterior casing; a plurality of electrical substrates stored in the exterior casing; a connecting member using a plurality of soldering balls or a plurality of pins, the connecting member being electrically conductive and mechanically fixing the electrical substrates adjacent and opposed to one another, in a state where each of the plurality of electrical substrates are arranged in a direction orthogonal to a longitudinal direction of the exterior casing such that the electrical substrates are substantially parallel to one another; a battery; and a flexible substrate which is provided with a power pattern which is electrically conductive with the battery and transmits power by the battery, and on which the power pattern is connected so as to be electrically conductive at end surfaces of the plurality of electrical substrates opposed to one another in the longitudinal direction of the exterior casing.

Abstract: There is provided a confocal endoscope system which is provided with an electronic endoscope having a confocal optical unit configured to emit illumination light toward an object and to obtain only light from a certain point of the object, and a processor to which the light obtained by the confocal optical unit is inputted. The processor is provided with an image processing unit that generates image data representing an image of the object based on the light transmitted from the confocal optical unit, and a measuring information superimposing unit that generates composite image data representing a composite image generated by superimposing measuring information for measuring the object on the image generated by the image processing unit. The measuring information superimposing unit determines a display condition of the measuring information on the composite image in accordance with an imaging area of the confocal optical unit.

Abstract: The endoscope apparatus of the present invention includes: an insertion portion having a bending portion; an observation device that is provided at the insertion portion; an illumination unit that is provided at the insertion portion, and that illuminates a visual field of the observation device; a main body unit that is formed having a size that enables it to be held and operated by one hand of a user; an operating section that is used to operate the bending portion; a display unit that is connected to the insertion portion, and that displays images acquired by the observation device; a light emitting component that is provided in the main body unit, and that is connected via a light guide to the illumination unit; a heat discharge unit that is provided at the main body unit such that at least a portion thereof is exposed, and that is thermally connected to the light emitting component; and a shielding portion that is provided at the main body unit, and that covers at least a portion of the periphery of the

Abstract: A rod lens is used for fitting in an endoscopes. The rod lens has a rod-shaped body which is made at least in a section of a flexible, transparent solid piece of plastic material.

Abstract: An in vivo imaging device and method, the device including at least one illumination source; at least one image sensor; and at least two optical systems. The optical systems have different depths of focus. A first and second image are focused onto the image sensor.

Abstract: The present invention relates to an encapsulated medical imaging device (1) and method for imaging the gastroin-testinal tract in patients using optical scanning technologies.

Abstract: A body-insertable apparatus includes: an illuminating unit that illuminates the inside of a subject's body; an imaging unit that takes an image of the inside of the subject's body; a first power supplying unit that supplies electric power to the imaging unit; a second power supplying unit that supplies electric power to the illuminating unit; and a switch that either connects the first power supplying unit to the second power supplying unit or disconnects the first power supplying unit from the second power supplying unit. The switch electrically separates the first power supplying unit from the second power supplying unit during at least an illuminating period of the illuminating unit.

Abstract: An electronic endoscope system has a video-scope, an illumination apparatus, an imaging device, and an image synthesizing processor. The illumination apparatus illuminates a normal light and an excitation-light from the video-scope onto an object. The normal light is reflected off the object, and the excitation-light causes the object to emit fluorescence. The imaging device on the video-scope captures a normal image that is formed by the reflected normal light and a fluorescent image that is formed by the fluorescence. The image synthesizing processor synthesizes the normal image and the fluorescent image into a synthesized image. A color signal of the synthesized image is the same as a color signal of the normal image. A luminance signal or the synthesized image is obtained by mixing a luminance signal of the normal image and a luminance signal of the fluorescent image in a predetermined proportion.

Abstract: The required minimum amount of examination site information is acquired, stored, or transmitted without missing an affected area, thus reducing power consumption, reducing the size of a battery disposed in a capsule, and reducing the size of a casing. Provided is a capsule medical device including a casing having a capsule shape; a light-detecting section, disposed in the casing, for detecting information about the intensity of light from outside the casing; an information-acquiring section for acquiring examination site information from an examination site positioned outside the casing; and a determination section for determining whether or not to acquire, store, or transmit, to the outside, the examination site information acquired by the information-acquiring section on the basis of the information about the intensity of the light detected by the light-detecting section.

Abstract: A capsule-type endoscope includes a capsule, an objective optical system, an image pickup element, and at least one illumination light source having a light-emitting surface, and a transparent cover. In several embodiments of the capsule-type endoscope according to the present invention, an inner surface of the transparent cover is spherical within a field of view of the objective optical system so as to have a center of curvature, the center of curvature is offset from the optical axis of the objective optical system, and a specified condition is satisfied so as to avoid flare in the objective optical system caused when light from the one (or more) illumination light source(s) enters the entrance pupil of the objective optical system. In another embodiment, the inner surface of the transparent cover has the shape of an ellipsoid. Observation methods using the capsule-type endoscope are also disclosed.

Abstract: A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.

Abstract: A storage unit is provided for removably storing an in vivo imaging capsule. The capsule may have a housing and an optical dome. The storage unit may include a recessed space formed for accepting the capsule. A magnet for magnetically activating and deactivating the capsule may be provided in the storage unit, for example in the lid. The storage unit may also include a capsule holding unit comprising at least two protruding elements to removably hold the capsule in the storage unit, wherein the protruding elements are positioned to grip the capsule housing.

Abstract: In order to maintain stability when connected, a cradle 27 includes an engagement part 33 for engaging with regard to a unit connection part which allows an antenna unit having at least a receiving antenna to be detachably connected to a receiving unit constituting a receiving apparatus together with the antenna unit; and a connecting terminal 31 provided so as to be communicably connected to a connector provided to the receiving unit only when the unit connection part and the engagement part are in engaged state.

Abstract: A capsule medical apparatus including: an illuminating unit; an image pick-up unit; an objective optical system; a sealed capsule container which seals the above components; a fixing frame to which a first objective lens of the objective optical system is fixed, the fixing frame being fixed at a reference position of an image area of the image pick-up unit such that a reference position of the fixing frame matches the reference position of the image area of the image pick-up unit; a guiding frame extended in an optical path direction on a surface of the fixing frame on an opposite side not facing the image pick-up unit; and a movable frame to which a second objective lens of the objective optical system is fixed, the movable frame being positioned and fixed in the optical path direction by being moved in the optical path direction relative to the guiding frame.

Abstract: A substantially spherical in vivo imaging device may be used for imaging body lumens in the GI tract. The imaging device may include for example a ballast weight for setting a preferred orientation of the device within the body lumen. The substantially spherical shape of the in vivo imaging device may facilitate capturing steady streams of imaging data in large body lumens. A method of manufacture is presented.

Abstract: An apparatus according to one embodiment includes an endoscope tip including a housing that is monolithically formed of a transparent material. At least one optical component is at least partially encased within the housing. The optical component can be, for example, a light source, a fiber optic, an imaging sensor, a lens, a reflector or a light shield. In another embodiment, an apparatus includes an endoscope having a distal end portion that includes a housing. The housing is monolithically formed with a transparent material and a light source is at least partially encased within the housing. The housing also includes a micro-defects portion within the transparent material of the housing. The micro-defects portion is configured to provide a selected output shape of a beam of light produced by the light source.

Abstract: An insertion unit has a channel through which a treatment tool can be inserted. A distal end of the insertion unit has a single-focus objective optical system or a focal-point-variable objective optical system to focus the optical image on a light receiving surface of an image capturing element. At a short object distance from the distal end, an image signal with a sufficient resolution is obtained from the image capturing element. In this state, a treatment tool projected by a reduced amount from a distal end opening of the channel is captured on a light receiving surface of the image capturing element. A required resolution is also provided for a far side.

Abstract: Fluid lens system, e.g. for medical imaging or medical treatment, with a container enclosing a fluid arranged to refract incoming waves. A pressure release mechanism is in contact with the fluid so as to compensate changes in its volume due to thermal variations, e.g. during high temperature medical cleaning. This pressure release mechanism is positioned within a pathway of incoming waves. In preferred embodiments a fluid container connected via a tube to the fluid as a reservoir, is arranged within or outside the container, e.g. beyond an image sensor. Alternatively, an easily compressible body, e.g. a small closed metal bellows enclosing a gas, is positioned inside the fluid to absorb volume changes by compression. In both embodiments, the pressure release elements are preferably positioned in a peripheral part of the pathway of incoming waves to not affect performance of the lens.

Abstract: Light is collected from a sample that is to be imaged, such as tissue or the like, and made to undergo self-interference, e.g., on a detector. An imaging system may include a low coherence light source arranged for illuminating the sample, and an interferometer arranged to receive the light collected from the sample and to pass it to a detector. The interferometer includes a beam divider that directs the radiation collected from the sample along two paths, phase-delaying one beam relative to another and then recombining the beams on a detector. A processor may be coordinated with the phase delay and in some embodiments with spatial scanning or detector array addresses, and operates on the signal from the detector to form a tomographic image of the sample illuminated tissue.

Abstract: An endoscope processor comprising a signal receiver and a standard value calculator is provided. The signal receiver receives an image signal generated based on an optical image captured at a light receiving surface on an imaging device. The image signal comprises a plurality of pixel signals generated by a plurality of pixels according to amounts of received light. A plurality of the pixels are arranged on the light receiving surface. The standard value calculator calculates a standard value using a focused pixel signal and surrounding pixel signals. The surrounding pixel signals are the pixel signals of surrounding pixels. The surrounding pixels surround the focused pixel. The standard value is used for carrying out signal processing on the focused pixel signal.

Abstract: An endoscope processor comprising a signal receiver, an average calculator, a difference calculator, an emphasizer, a synthesizer, and an output block is provided. The signal receiver receives an image signal generated by an imaging device. The image signal comprises a plurality of pixel signals. The average calculator calculates a signal average value. The difference calculator calculates a signal difference value. The emphasizer calculates an emphasized value by multiplying the signal difference value by a predetermined gain. The synthesizer generates an emphasized image signal, in which the pixel signal for each pixel is replaced with the sum of the emphasized value for each pixel and the signal average value.