Absorbent Patch For Fluid Analysis Patents (Class 600/362)
  • Patent number: 10506968
    Abstract: The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the target analyte(s) in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte(s), as the sample is concentrated by the device. The invention further includes a method for using a fluid sensing device to concentrate a fluid sample with respect to one or more target analytes. The disclosed method further includes the ability to correlate the measured target analyte concentration to a physiological condition of a device wearer, or of a fluid source.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: December 17, 2019
    Assignees: Eccrine Systems, Inc., University of Cincinnati
    Inventors: Jason Heikenfeld, Jacob A. Bertrand, Michael Brothers, Andrew Jajack
  • Patent number: 10028685
    Abstract: A sensing device having a first and second opening, a first semipermeable membrane having a first surface and a second surface, and a second semipermeable membrane having a third and fourth surface, a ketone body sensor, and a void. The first opening is juxtaposed to the first surface and the second opening is juxtaposed to the third surface. The space between the first and second openings is the void and wherein the ketone body sensor is positioned within the void. Gasses may permeate through the first opening and into the void to contact the sensor and exit the void through the second opening.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: July 24, 2018
    Inventor: Stephen DeTurk
  • Patent number: 9131893
    Abstract: A health monitoring system, and methods of use and manufacture thereof are disclosed. The health monitoring system may include a computing system and a diagnostic test coupled to a diaper. The diagnostic test may include one or more sensors configured to produce a visual indication of one or more analytes contained in a sample produced by a subject. The diagnostic test may include a machine-readable code. The computing system may be configured to read the machine-readable code to allow an application running on the computing system to automatically perform at least one task related to a production of a data point based on the visual indication. The health monitoring system may aid in identifying a potential abnormal health condition of the subject by providing automatic longitudinal analysis of analytes contained in samples produced by the subject over a period of time.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: September 15, 2015
    Assignee: Pixie Scientific, LLC
    Inventors: Yaroslav Faybishenko, Boris Faybishenko
  • Patent number: 8946501
    Abstract: A liquid leakage detection system requiring no power supply from an outer source and configured to be relatively simple and moderate in price. A liquid leakage detection system (10) including an infusion tube (11), a syringe needle (12) coupled to the infusion tube (11), an absorbent element (16) adapted to be placed in the vicinity of a point (12a) of the syringe needle (12) to be pricked through a patient skin and a sensor unit (14) located on an upper side or within the absorbent element (16).
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: February 3, 2015
    Assignee: Aqua Power System, Japan
    Inventors: Naoyuki Kamatani, Tadashi Ishikawa, Yoshiaki Hasebe
  • Publication number: 20150025347
    Abstract: A lateral flow device for testing a bodily fluid, such as urine, blood, mucous, saliva, etc., is provided. The lateral flow device is configured to be attached to an absorbent article via an attachment mechanism located on the lateral flow device or the absorbent article. The lateral flow device includes a chromatographic medium (e.g., porous membrane) that defines a detection zone that provides a signal indicative of the presence or absence of the analyte. The device may also include a control zone that provides a signal indicative of whether a sufficient amount of bodily fluid has been provided and tested. Regardless of its specific configuration, the lateral flow device is configured to be attached onto the absorbent article to provide a user or caregiver with rapid information about a health condition. For example, the device may be attached onto a diaper to provide information about the presence of enzymes or other compounds often encountered with a patient having a urinary tract infection.
    Type: Application
    Filed: August 4, 2014
    Publication date: January 22, 2015
    Inventor: Xuedong Song
  • Publication number: 20140357971
    Abstract: The present invention discloses a tear analyzing strip (TAS) for measuring dry eye syndrome in a patient. The TAS comprises an elongated body comprising a proximal portion and a distal portion interconnected by a main longitudinal axis. The distal portion comprises at least one tear channel comprising at least one tear receiving portion in fluid communication with an eye of the patient such that tears sampled from the eye into the channel. Reagent pads disposed along the length of the distal portion. The reagent pad is in fluid communication with the tear channel such that tears flow through the tear channel towards the reagent pads, thereby progressively wetting the reagent pads. Each of the reagent pads comprises an effective measure of a reagent capable of biological, physical, or chemical activation by the tears or a component thereof and of providing a visible indication of the activation.
    Type: Application
    Filed: November 29, 2012
    Publication date: December 4, 2014
    Inventors: Eran Eilat, Robert David
  • Patent number: 8901366
    Abstract: In accordance with one embodiment of the present disclosure, a method for quantitatively or semi-quantitatively determining the volume of a test sample of urine is provided. The method includes contacting the test sample with a fluidic medium of a lateral flow device having a volume indicator disposed thereon and determining the volume of urine in the test sample based on the distance traveled by the volume indicator along the fluidic medium, the distance traveled by the volume indicator corresponding to the volume of urine in the test sample.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: December 2, 2014
    Assignee: Kimberly Clark Worldwide, Inc.
    Inventors: Xuedong Song, RameshBabu Boga, Ning Wei
  • Publication number: 20140296667
    Abstract: A device (1) is provided that is configured to indicate the presence or absence of one or more biological entities in a biological sample. The device comprises a sampling portion (11), the sampling portion comprising flexible material adjustably conformable to a part of a human or animal body, at least a portion of the sampling portion being absorbent and configured to receive a biological sample directly from the body; and a test portion (12) in fluid engagement with the sampling portion, the test portion comprising one or more test zones (14). The sampling portion and test portion are configured such that at least a portion of the sample received by the sampling portion is transferable to the test portion such as to contact one or more of the test zones, and wherein each test zone is configured to indicate the presence or absence of one or more biological entities in the sample.
    Type: Application
    Filed: January 27, 2011
    Publication date: October 2, 2014
    Applicant: RESPIRIO PTY LTD
    Inventors: Steven David Dahl, Sean Andrew Parsons, Jennifer Maschmann, Kon Euan Gerard Wong, Tim Ian Spink, Stephen Robert Wilson
  • Patent number: 8758311
    Abstract: A transdermal product delivery patch comprises a reservoir containing a product for delivery to a patient; means for affixing the patch to the skin of the patient; and manually operable means for actuating an extensor mechanism to exert pressure on the reservoir and thereby expel the product towards the skin. The patch may be supplied with the extensor mechanism held in a strained configuration and the manually operable means may be a restraint such as a peelable layer that can be removed to allow the extensor mechanism to move using stored energy towards a rest configuration. The extensor mechanism may be a ring of resilient material that is pre-stretched radially inwards so that, upon release, it stretches the reservoir radially outwards. The patch may be supplied with the extensor mechanism in a rest configuration and the manually operable means may deform it in a predefined manner into a strained configuration.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: June 24, 2014
    Assignee: Nemaura Pharma Limited
    Inventor: Dewan Fazlul Hoque Chowdhury
  • Patent number: 8747316
    Abstract: An in vivo component measurement method allowing how long a high concentration state of a measurement target component continues in an organism to be grasped is provided. In this in vivo component measurement method, a value relating to an amount of a measurement target component in tissue fluid extracted for 60 minutes or more from an organism on which a treatment for enhancing extraction of tissue fluid has been made is acquired.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: June 10, 2014
    Assignee: Sysmex Corporation
    Inventor: Seiki Okada
  • Patent number: 8742198
    Abstract: A dehydration sensor having a stable, printable, buffered-ink composition that enables one to miniaturize the detection zone and permits both buffer and indicator dye to be applied in the same area of a detection zone, without need for a conventional, large buffer pad region. The ink composition includes a weak polymeric base as its primary buffering agent.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: June 3, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Ning Wei, Xuedong Song, Ronnie L. Phillips
  • Patent number: 8704035
    Abstract: A dehydration sensor having a stable, printable, buffered-ink composition that enables one to miniaturize the detection zone and permits both buffer and indicator dye to be applied in the same area of a detection zone, without need for a conventional, large buffer pad region. The ink composition includes a weak polymeric base as its primary buffering agent.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: April 22, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Ning Wei, Xuedong Song, Ronnie L. Phillips
  • Publication number: 20140066734
    Abstract: In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.
    Type: Application
    Filed: August 30, 2013
    Publication date: March 6, 2014
    Applicant: Proteus Digital Health, Inc.
    Inventor: Mark Zdeblick
  • Publication number: 20140051951
    Abstract: The present invention relates to the analysis apparatus capable of collecting the body fluid such as urine or blood, for embodiment urination and measuring or calculating the specific constituent from the collected body urine, and the apparatus for collecting body fluid capable of using by connecting to the analysis apparatus and its related article, in which the apparatus for collecting and analyzing for the body fluid of a patient consists of the body fluid collecting part and the collecting part case, the apparatus for collecting body fluid consists of the body fluid collecting part, the total tube and adapter, the collecting part is constructed with the absorbing tube, the sensor tube, the cleansing tube and the passage and is attachable/detachable connected to the collecting part, a diaper and pants exclusive for a patient are provided as the related article such that it is convenient to possess and has effects in the urination having no relations to the intention of a patient or in case of unable to use
    Type: Application
    Filed: July 18, 2013
    Publication date: February 20, 2014
    Inventor: Kyoung-Hun KIM
  • Publication number: 20140018654
    Abstract: The present invention is directed toward a wound dressing comprising a foam body made of polyvinyl acetal material treated with a plurality of colored biocidal dyes with at least one of the dyes being gram positive and at least one of the dyes being gram negative to dye the body a distinct color. The body has at least one planar surface and ranges from about 1 mm to about 3 mm in thickness and has an outer adhesive section secured to the body. The body when placed in contact with an infected wound site changing color.
    Type: Application
    Filed: July 12, 2012
    Publication date: January 16, 2014
    Inventor: Thomas J. Drury
  • Publication number: 20130267807
    Abstract: Apparatus for eliciting a blood sample comprises: a housing; a shaft mounted within the housing; an aperture in the housing, the aperture being configured to receive a part of a user; a member rotatably mounted on the shaft; a lancet protruding from one position at an edge of the member, and a blood collection part located at a second, different position at the edge of the member. The apparatus is configured such that: when the member is in a first rotational position the lancet is shielded by the housing, when the member is in a second rotational position the lancet is operable to lance the part of the user received at the aperture, and when the member is in a third rotational position the blood collection part is presented such as to receive blood from the part of the user received at the aperture.
    Type: Application
    Filed: July 7, 2011
    Publication date: October 10, 2013
    Applicant: Sanofi-Aventis Deutschland GmbH
    Inventors: Ross MacArthur, Frank Richter
  • Publication number: 20130261409
    Abstract: Various methods, devices and systems for patch based physical, physiological, chemical, and biochemical sensors that diagnose and monitor disease states are described. The patch based sensors provide a panel of specific analyte parameters that determine one or more physiological conditions and/or the level of healing progression of a wound. The use of such analyte panels in local or remote monitoring of parameters related to various disease states is also described.
    Type: Application
    Filed: November 30, 2010
    Publication date: October 3, 2013
    Inventors: Srikant Pathak, David N. Edwards
  • Publication number: 20130197334
    Abstract: The invention concerns a Biodetector with a functionalised surface for isolating molecules or cells from the human body. In order to improve a Biodetector of the type mentioned above such that the functionalised surface of the Biodetector or there upon enriched molecules or cells are exposed to a lower abrasion, and the biocompatibility of the Biodetector is improved, the Biodetector is designed to remove a fluid from the human body and absorb it into an inner space of the Biodetector, wherein the functionalised surface is oriented to the inner space of the Biodetector.
    Type: Application
    Filed: March 15, 2011
    Publication date: August 1, 2013
    Applicant: GILUPI GMBH
    Inventors: Ekkehardt Weber, Robert Niestroj
  • Patent number: 8454550
    Abstract: An apparatus is disclosed for detecting moisture, which is intended for the use in an apparatus for monitoring an access to a patient for a device by means of which a fluid is conducted to and/or removed from a patient via a hose line, in particular for monitoring the vascular access during an extracorporeal blood treatment, wherein blood of a patient is removed from the patient via an arterial hose line, which has an arterial puncture cannula, and is conducted back to the patient via a venous hose line, which has a venous puncture cannula. The apparatus for detecting moisture is designed as a pad which is made of a flexible material and is to be applied onto the patient's skin and which comprises an upper side facing away from the patient's skin and a lower side facing the patient's skin. The pad comprises an opening for the passage of fluid, in particular blood, and a moisture sensor having contact elements for the connection of the same.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: June 4, 2013
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Christoph Koenig, Alexander Schroers, Andreas Wuepper, Alexander Heide, Juergen Klewinghaus
  • Publication number: 20130096400
    Abstract: A device (1) is provided that is configured to indicate the presence or absence of one or more biological entities in a biological sample. The device comprises a sampling portion (11), the sampling portion comprising flexible material adjustably conformable to a part of a human or animal body, at least a portion of the sampling portion being absorbent and configured to receive a biological sample directly from the body; and a test portion (12) in fluid engagement with the sampling portion, the test portion comprising one or more test zones (14). The sampling portion and test portion are configured such that at least a portion of the sample received by the sampling portion is transferable to the test portion such as to contact one or more of the test zones, and wherein each test zone is configured to indicate the presence or absence of one or more biological entities in the sample.
    Type: Application
    Filed: January 27, 2011
    Publication date: April 18, 2013
    Applicant: RESPIRIO PTY LTD
    Inventors: Steven David Dahl, Sean Andrew Parsons, Jennifer Maschmann, Kon Euan Gerard Wong, Tim Ian Spink, Stephen Robert Wilson
  • Publication number: 20130053668
    Abstract: The present invention relates to a kit for detecting blood sugar. The present invention also relates to a method for detecting blood sugar according to the kit. The kit comprises an adhesive sweat absorption device comprising: a sweat absorption patch for absorbing sweat of a subject; a detector layer for generating electronic signals according to the sugar level of sweat absorbed by the sweat absorption patch; a signal amplifier for amplifying electronic signals generated by the detector layer; a wireless transmitter for sending amplified electronic signals generated by the signal amplifier to a remote signal receiver, in order to calculate blood sugar level; and a power supply device for supplying electric power required for operation of detector layer.
    Type: Application
    Filed: August 24, 2012
    Publication date: February 28, 2013
    Applicant: COMPOSE ELEMENT LIMITED
    Inventor: Tsu-Tai Lin
  • Publication number: 20130006080
    Abstract: A living body component analyzing method that can accurately analyze a measurement target component even when the subject perspires is provided. A living body component analyzing method for analyzing a component contained in a tissue fluid extracted from the skin of a subject includes: a step of subjecting part of the skin of the subject to a process of facilitating extraction of the tissue fluid; a step of collecting a measurement target component from the skin subjected to the facilitation process; a step of collecting a first auxiliary component from the skin subjected to the facilitation process; a step of collecting a second auxiliary component contained in perspiration from the skin excluding the part subjected to the facilitation process; and a step of analyzing the measurement target component based on the collected measurement target component, the first auxiliary component and the second auxiliary component.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 3, 2013
    Applicant: PANASONIC CORPORATION
    Inventors: Seiki OKADA, Yoshihiro ASAKURA, Toshiyuki SATO, Kei HAGINO, Junko KOJIMA
  • Patent number: 8235930
    Abstract: A fluid loss detection device for dressings at pre-existing port sites, catheter sites, operative sites, ostomy sites, drain sites, line sites such as those utilized in hemodialysis, wound sites, or other areas for which monitoring of fluid or blood loss is medically indicated. The detection device includes a patch having a primary loop circuit and an early warning alarm circuit loop. In one embodiment, closure of the early warning alarm circuit loop activates an alarm. The alarm may be connected directly to the patch and sound locally or may be activated remotely via radio transmission. The alarm may alternatively cause a medical device such as a hemodialysis system to shut down.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: August 7, 2012
    Inventor: Kenneth Shawn McCall
  • Publication number: 20120165626
    Abstract: Devices, methods, and kits for measuring or otherwise evaluating the concentration of one or more analytes in a body fluid are described. The devices, methods, and/or kits may be non-invasive. In some variations, a method for measuring the concentration of an analyte in sweat of a subject may comprise contacting a colorimetric membrane with a skin surface of the subject so that the membrane collects a volume of sweat from the skin surface, and analyzing the colorimetric membrane to determine the concentration of the analyte in the collected volume of sweat.
    Type: Application
    Filed: July 1, 2010
    Publication date: June 28, 2012
    Inventors: Finkelshtein V. Irina, James W. Moyer, Russell O. Potts, Burton H. Sage, Robert J. Shartie, Donald R. Wilson, Bruce D. Wong
  • Patent number: 8188332
    Abstract: The invention refers to a disposable cover for use in an incubator for premature infants comprising a moisture-pervious surface layer and a preferably moisture-impervious back sheet, wherein the total weight of the cover before use is communicated to the caregiver by indication on said cover, a label accompanying said cover or on the package for said cover. The cover may further be provided with a wetness indicator.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: May 29, 2012
    Assignee: SCA Hygiene Products AB
    Inventors: Ingemar Fernfors, Anna-Gerd Doverbo
  • Publication number: 20120095308
    Abstract: Provided is a strip-shaped detector that detects an analyte in a liquid sample. The detector includes a collecting member that directly collects a liquid sample from a living organism, a holding member that holds a labeling reagent binding specifically to the analyte in a state where the labeling reagent can move along with the movement of the liquid sample, a detecting member to which a detection reagent is immobilized which captures a complex of the analyte and the labeling reagent by binding specifically to the analyte, an absorbing member that can absorb the liquid sample, and a liquid-impermeable supporting member, wherein the respective members are arranged on the supporting member in the longitudinal direction of the detector so that the liquid sample moves through the inside of these members, and the collecting member includes a protruding portion sticking out of the supporting member at the upstream side in the movement direction of the liquid sample.
    Type: Application
    Filed: April 9, 2009
    Publication date: April 19, 2012
    Inventors: Masayuki Higuchi, Yuuichi Nakano, Nahoko Suzuki, Miki Tanimoto, Kouhei Yamashita
  • Patent number: 8084268
    Abstract: A substrate is filled with a reagent that presents a stable free radical character, and that is capable of producing a visible reaction in the presence of at least one free radical scavenger analyte of the skin.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: December 27, 2011
    Assignee: L'Oreal
    Inventors: Francis Pruche, Quang Lan Nguyen, Jean-Pascal Hirt
  • Patent number: 8053625
    Abstract: Wetness indicators may include alarm devices that are designed to assist parents or attendants in identifying a wet diaper condition early on. These devices produce either a visual or an audible signal. Many of these devices rely on electronics, which may increase the expense of the absorbent article. Further, electronic devices rely on electrical sources and may be prone to failure if not utilized for an extended period of time.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: November 8, 2011
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Davis Dang H. Nhan, Andrew M. Long, Shirlee A. Weber, Darold D. Tippey, Meghan E. Collins
  • Publication number: 20110236322
    Abstract: Example embodiments of the present invention include various compositions that include a pH modifier composition and/or a buffering capacity modifier composition. In some examples, the pH modifier compositions include a dose of pH modifier to raise the pH in a patient's mouth from about 1 to about 2 pH levels. The compositions are then incorporated into various confections for oral ingestion or application that allow a patient to easily use the composition with the pH and/or buffering capacity modifiers. For example, compositions with the pH and/or buffering capacity modifiers can be incorporated within chewing gum, tablets, lozenges, breath strips, hard candy, oral sprays, and other confections. Another embodiment of the invention includes a testing device to test the pH and buffering capacity within a patient's mouth.
    Type: Application
    Filed: March 25, 2011
    Publication date: September 29, 2011
    Applicant: CAO Group, Inc.
    Inventors: Steven D. Jensen, Densen Cao
  • Publication number: 20110166433
    Abstract: A fluid sampling system is disclosed comprising a fluid drawing device and a fluid sampling device. In one embodiment, the fluid sampling device has a base portion having a cannula, a handle, and a ridge extending around at least a portion of an outer surface. A top portion has a flange adapted to engage the ridge to couple the top portion to the base portion. In another embodiment, the fluid sampling device has a base portion having a cannula, a handle, a mounting portion, and a test strip coupled to the base portion at least partially within the mounting portion. In yet another embodiment, the fluid sampling device has a test strip housing for receiving an end of a test strip therein. Extending from an end of the test strip housing is a blunt cannula.
    Type: Application
    Filed: February 17, 2011
    Publication date: July 7, 2011
    Applicant: GLUCOR SYSTEMS, LLC
    Inventors: Corey Dalebout, Josh Sybrowsky
  • Publication number: 20110166432
    Abstract: A diagnostic agent is delivered intravaginally or to the interlabial space by positioning an interlabial device, such as an absorbent pad, between the labia. The pad is retained between the labia to deliver an active agent, or allow a reaction with a diagnostic agent. Alternatively, the pad is applied after the diagnostic agent is administered, to help reduce discomfort to the subject, or loss of the diagnostic agent. The active agent may be carried by the pad itself, or in an intravaginal extension of the pad, or separately in a suppository or other dosage form. In particular examples, the pad has a smaller minor portion superimposed on a larger major portion, and the smaller minor portion is inserted as a leading edge between the labia of the subject to facilitate interlabial insertion. In another example, the pad is placed interlabially after insertion of an agent.
    Type: Application
    Filed: January 12, 2011
    Publication date: July 7, 2011
    Inventor: William H. Fleming
  • Publication number: 20100256064
    Abstract: A microprotrusion array for use in transport of a material across a biological barrier, wherein said array comprises a plurality of microprotusions composed of a swellable polymer composition.
    Type: Application
    Filed: September 29, 2008
    Publication date: October 7, 2010
    Inventors: David A. Woolfson, Desmond Ian John Morrow, Anthony Morrissey, Ryan F. Donnelly, Paul A. McCarron
  • Patent number: 7781640
    Abstract: A disposable absorbent article including a wetness sensation member and visible highlighting indicating the presence of the wetness sensation member to facilitate an opportunity for the toilet training of the wearer. The wetness sensation member includes a permeable layer and a flow control layer. Urine deposited on the wetness sensation member can penetrate through the permeable body-facing layer in a z direction away from the wearer to the flow control layer. The flow control layer retards the passage of the urine through the wetness sensation member in the z direction while supporting the movement of the urine in an x-y plane to increase the wetted area contacting the wearer's skin and thereby enhance the wearer's awareness that urination has occurred. The visible highlighting is visible when viewing a body-facing surface of the article and may be associatively correlated with an externally visible marking and/or with the concept of toilet training.
    Type: Grant
    Filed: November 17, 2005
    Date of Patent: August 24, 2010
    Assignee: The Procter & Gamble Company
    Inventors: Mary Elizabeth Davis, Donald Carroll Roe, Patrick Jay Allen, Edward Paul Carlin
  • Patent number: 7767876
    Abstract: A disposable absorbent article including a wetness sensation member and visible highlighting indicating the presence of the wetness sensation member to facilitate an opportunity for the toilet training of the wearer. The wetness sensation member includes a permeable layer and a flow control layer. Urine deposited on the wetness sensation member can penetrate through the permeable body-facing layer in a z direction away from the wearer to the flow control layer. The flow control layer retards the passage of the urine through the wetness sensation member in the z direction while supporting the movement of the urine in an x-y plane to increase the wetted area contacting the wearer's skin and thereby enhance the wearer's awareness that urination has occurred. The visible highlighting is visible when viewing a body-facing surface of the article and may be associatively correlated with an externally visible marking and/or with the concept of toilet training.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: August 3, 2010
    Assignee: The Procter & Gamble Company
    Inventors: Mary Elizabeth Davis, Donald Carroll Roe, Patrick Jay Allen, Edward Paul Carlin
  • Patent number: 7725149
    Abstract: Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: May 25, 2010
    Inventors: Thomas A. Peyser, Russell O. Potts, Herbert L. Berman, James W. Moyer, Mikhail A. Kouchnir
  • Patent number: 7670289
    Abstract: A fluid loss detection device for dressings at pre-existing port sites, catheter sites, operative sites, ostomy sites, drain sites, line sites such as those utilized in hemodialysis, wound sites, or other areas for which monitoring of fluid or blood loss is medically indicated. The detection device includes a patch having a primary loop circuit and an early warning alarm circuit loop. In one embodiment, closure of the early warning alarm circuit loop activates an alarm. The alarm may be connected directly to the patch and sound locally or may be activated remotely via radio transmission. The detection device may additionally cause a medical device such as a hemodialysis system to shut down.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: March 2, 2010
    Inventor: Kenneth Shawn McCall
  • Patent number: 7641612
    Abstract: A blood loss detection device for a hemodialysis system having a blood intake line, a dialysis machine including a pump, with the dialysis machine in communication with the blood intake line, and a blood return line in communication with the dialysis machine. The detection device includes a patch having an exterior edge and an opening through the patch forming a target for receipt of the return blood line. A slit through the patch extends between the exterior edge and the opening. A primary loop circuit terminates at two ends at the slit. An early warning alarm circuit loop terminates at two ends at the slit. An emergency shut-down circuit loop terminates at two ends at the slit. A modular connector connects the patch to an alarm activated by the early warning alarm circuit and to a switch mechanism activated by the shut-down circuit in order to shut down the dialysis machine and the pump.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: January 5, 2010
    Inventor: Kenneth Shawn McCall
  • Patent number: 7383072
    Abstract: A method of sensing the concentration level of at least one particular electrolyte in the sweat fluid of a subject, includes providing a sweat sensor system having sweat fluid absorbing material, measuring apparatus for sensing the electrical conductivity of sweat fluid absorbed by the absorbing material and producing ionic concentration data for said at least one particular electrolyte, and a user interface connected to the measurement apparatus for interpreting the data to a user. The absorbing material is applied to the skin of the subject to cause sweat fluid thereon to be absorbed by the absorbing material whereby the measurement apparatus produces ionic concentration data for the sweat fluid absorbed and the user interface interprets the data for a user.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: June 3, 2008
    Assignee: P. J. Edmonson Ltd
    Inventors: Peter J. Edmonson, Douglas W. Stoddard
  • Patent number: 7365238
    Abstract: A wearable article comprising a dehydration indicator adapted to measure a urine ionic strength correlated to a specific gravity of the wearer's urine and provide a visible signal when the urine ionic strength reaches a value corresponding to a predetermined threshold of the specific gravity. The wearable article may be a disposable absorbent article. The dehydration indicator may also be comprised in an insert for use with a wearable article. The dehydration indicator may provide qualitative or quantitative information about the ionic strength of the wearer's urine.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: April 29, 2008
    Assignee: The Procter and Gamble Company
    Inventors: Joseph Raymond Diehl, Donald Carroll Roe, Patrick Jay Allen
  • Patent number: 7276041
    Abstract: A method of alerting medical personnel of a problem during hemodialysis includes providing an active, fail-to-safe site sensor for a fistula needle at an access site during hemodialysis; and automatically alerting medical personnel of a problem during hemodialysis using the active, fail-to-safe site sensor during at least the following: failing of the active, fail-to-safe site sensor; insufficient powering to the active, fail-to-safe site sensor; partial fistula needle dislodging from the access site; and complete needle dislodging from the access site.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: October 2, 2007
    Assignee: Bradley Jon Moll, Rodney L. Moll and Ann E. Moll Family Trust
    Inventor: Bradley Jon Moll
  • Patent number: 7175430
    Abstract: The invention relates to deformable, curable or film-forming support materials which contain diagnostically useful additives for locus- and substance-specific intraoral diagnostics, and processes for the preparation of images for intraoral locus- and substance-specific diagnostic purposes, in which diagnostically useful additives are applied to deformable, curable or film-forming support materials containing no diagnostically useful additives, in such a quantity that a diagnostic signal can be observed, the diagnostic result being obtained without a cultivation step.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: February 13, 2007
    Assignee: 3M ESPE AG
    Inventors: Oswald Gasser, Rainer Guggenberger, Bernd Gangnus, Ingo Häberlein
  • Patent number: 7041057
    Abstract: A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: May 9, 2006
    Assignee: SpectRx, Inc.
    Inventors: Mark L. Faupel, Krishna Kumar, J. David Farquhar, Mark Vreeke, Alan Smith, Michael Hatch, Teresa Woods
  • Patent number: 7037262
    Abstract: The invention relates to attachable body fluid collection devices, each comprising at least one storage structure for, when in use, storing a body fluid sample secreted by a body fluid secreting surface. The or at least one of the storage structure comprises silicon. Particular emphasis is placed on sweat patches and techniques for analyzing sweat.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: May 2, 2006
    Assignee: pSiMedica Limited
    Inventors: Roger Aston, Leigh T Canham
  • Patent number: 6982360
    Abstract: The invention relates to a pantyliner, in particular for pregnant women, with a liquid-impermeable lower layer and a liquid-permeable covering layer, where a test insert (3) provided with a test substance is arranged between the lower layer (1) and the covering layer (2).
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: January 3, 2006
    Inventor: Hülya Buzluhan
  • Patent number: 6979306
    Abstract: A method of alerting medical personnel of a problem during hemodialysis includes providing an active, fail-to-safe site sensor for a fistula needle at an access site during hemodialysis; and automatically alerting medical personnel of a problem during hemodialysis using the active, fail-to-safe site sensor during at least the following: failing of the active, fail-to-safe site sensor; insufficient powering to the active, fail-to-safe site sensor; partial fistula needle dislodging from the access site; and complete needle dislodging from the access site.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: December 27, 2005
    Assignee: Moll Family Trust
    Inventor: Bradley Jon Moll
  • Publication number: 20040193030
    Abstract: The invention relates to attachable body fluid collection devices, each comprising at least one storage means for, when in use, storing a body fluid sample secreted by a body fluid secreting surface, characterised in that the or at least one of the storage means comprises silicon. Particular emphasis is placed on sweat patches and techniques for analysing sweat.
    Type: Application
    Filed: January 30, 2004
    Publication date: September 30, 2004
    Inventors: Roger Aston, Leigh T Canham
  • Publication number: 20040133090
    Abstract: The invention relates to the medicine and can be used for the prophylaxis and diagnostics of a number of disorders in human organism and also for the revealing of some states accompanied by the changes in the content of diagnostically important metabolites in biological liquids. The object of the invention is to make a basically new sanitary means providing an additional function—testing for the purpose of an organism state analysis—along with his designated purpose and intended for daily use for the patients. The widely used sanitary hygienic article such as pampers or feminine hygienic napkin is provided with the special functional diagnostic means. The functional diagnostic means according to the invention comprises at least one chemical reagent disposed so that it can react with biological liquids secreted by an organism with the following comparison of the change in the content of reference (diagnostically significant) metabolites in liquid biological samples.
    Type: Application
    Filed: October 31, 2003
    Publication date: July 8, 2004
    Inventors: Ilya Andreevich Dostoinov, Dmitry Yurievich Bykhovsky, Viktor Andreevich Pastukhov, Valery Lvovich Kuznetsov
  • Patent number: 6723797
    Abstract: A crosslinking agent for water-absorbing resins which comprises (A) at least one halohydrin compound selected between (A1) a first halohydrin compound having per molecule at least two halohydrin groups (D) represented by the general formula (I), wherein R1 represents hydrogen or alkyl and X represents chlorine or bromine and (A2) a second halohydrin compound having per molecule at least two halohydrin groups (D) represented by the formula (I) and having per molecule at least one ammonium group (M) represented by the general formula (II), wherein R2's each independently represents a C1-4 hydrocarbon group or benzyl.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: April 20, 2004
    Assignee: Nagase Chemtex Corporation
    Inventors: Satoru Fujii, Yoshiyuki Morita, Tetsuya Hosomi, Nobuaki Aoki
  • Patent number: 6719691
    Abstract: A kit for generating a biological sample from a discharge emitted from a portion of a body includes an absorbent pad for deploying adjacent to the portion of the body and a portable device for preserving and/or pre-processing the sample. The pad includes a sampling membrane configured to retain at least one biological material. The portable device has a housing formed from a base portion and lid portion which together define a sealable sample chamber for receiving the sampling membrane. An injector device is configured to be activated by closing of the lid portion to inject sample extracting solution into the sample chamber.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: April 13, 2004
    Assignee: Common Sense Ltd.
    Inventors: Amnon Kritzman, Yael Bechar, Hadar Kessary Shoham
  • Patent number: 6591124
    Abstract: A strip-like microneedle device is provided that includes an array of hollow microneedles, a diaphragm pump to extract interstitial fluid from skin, and a sensor that detects the concentration of the fluid. The microneedle device can be interfaced to an external sensor to produce a reading, or can be self-contained. One version uses an attachable/detachable microneedle array as a single-use, disposable unit. The device is portable, and is used by placing one finger on the microneedle array, and actuating the diaphragm pump with another finger, thereby obtaining the fluid sample. Solid coated or transparent microneedles could instead be used as an in-situ sensor, with either electrodes or an optical sensor.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: July 8, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Faiz Feisal Sherman, Francisco Arias, Vladimir Gartstein, Grover David Owens, Milan Marcel Jevtitch, Chow Chi Huang