Measuring Or Detecting Nonradioactive Constituent Of Body Liquid By Means Placed Against Or In Body Throughout Test Patents (Class 600/309)
  • Patent number: 10321858
    Abstract: Provided are transdermal microneedle-based devices for sensing the presence and concentration of analytes such as electrolytes, biomarkers, drugs, and proteins in interstitial fluid. Also provided are methods and systems to transmit the data obtained by wired or wireless connection to a receiver and to relay the data to the user or a clinician.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: June 18, 2019
    Assignee: ProteaDX, Inc.
    Inventors: Jose Antonio Maiz-Aguinaga, Lennart Olsson
  • Patent number: 10299216
    Abstract: Vehicle management systems can be configured to help govern self-driving vehicles. A vehicle management system can communicatively couple a self-driving vehicle to a remote computing device of a user of the vehicle. Detecting a battery charge indication below a threshold can trigger several responses configured to minimize the risk of the self-driving vehicle failing to pick up the user due to the remote computing device having a low or dead battery.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: May 21, 2019
    Inventors: Eric John Wengreen, Wesley Edward Schwie
  • Patent number: 10286198
    Abstract: Devices and methods are provided for controlled delivery of medical substances such as drugs and medication. For example, a microchip medical substance delivery device includes a control system, and a medical substance capsule that comprises a medical substance contained with a reservoir, and a release structure to release the medical substance from within the reservoir in response to an activation signal generated by the control system. The control system comprises a wireless signal receiving element, processor, actuator circuit, and power supply source. The wireless signal receiving element captures a wireless signal. The processor detects an activation code embedded within the captured wireless signal, and generates an actuator control signal in response to the detection of the activation code. The actuator circuit generates the activation signal in response to the actuator control signal generated by the processor. The power supply source provides power to operate components of the control system.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: May 14, 2019
    Assignee: International Business Machines Corporation
    Inventors: Bing Dang, Duixian Liu, Jean-Olivier Plouchart
  • Patent number: 10285759
    Abstract: The invention provides systems and method for the removal of diseased cells during surgery.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 14, 2019
    Assignee: Lumicell, Inc.
    Inventors: W. David Lee, Jorge Ferrer
  • Patent number: 10252052
    Abstract: The invention contemplates, inter alia, the use of remote ischemic conditioning in the treatment of a variety of disorders.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 9, 2019
    Assignee: The Hospital for Sick Children
    Inventor: Andrew Redington
  • Patent number: 10245422
    Abstract: Applicators for a microprojection array and methods of using the applicators are described.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: April 2, 2019
    Assignee: Corium International, Inc.
    Inventors: Anthony Le, Doug Bourne, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • Patent number: 10238325
    Abstract: A biological fluid sampling device for collecting a blood sample from a separate vascular access device and for ejecting a portion of the collected sample to a point-of-care testing device for analysis is provided. The biological fluid sampling device includes a body enclosing a reservoir. The reservoir has an internal volume sufficient to contain enough blood for use in a diagnostic test. The sampling device further includes: an access lumen extending from a distal end of the body for establishing fluid communication between a separate vascular access device and the reservoir; an outflow lumen also in fluid communication with the reservoir; and a removable vented cap attached to the outflow lumen including a gas permeable vent in gaseous communication between the reservoir and ambient air. In addition, several sample and transfer devices are provided for obtaining a sample from a subject and transferring the sample to a point-of-care testing device.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 26, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Jonathan Karl Burkholz, Bryan Garret Davis
  • Patent number: 10231654
    Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: March 19, 2019
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Thomas A. Peyser, Adam Heller
  • Patent number: 10219710
    Abstract: A device for adjusting and determining the blood flow plateau at a patient's limb, wherein the device includes an chamber the wall of which surrounds an inner space, and at least one opening for inserting at least a part of the limb into the inner space as well as at least one recess, that allows access to the part of the limb that is located inside the inner space, are formed in the chamber, and wherein the device includes at least one heating element that is in thermal contact with the inner space. In this context, it is provided that the device further includes an apparatus for determining the blood flow plateau at the part of the limb that is located inside the inner space.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: March 5, 2019
    Assignee: TECHNISCHE UNIVERSITÄT DRESDEN
    Inventors: Graeme Eisenhofer, Christina Pamporaki, Angelos Filippatos
  • Patent number: 10211679
    Abstract: A system using a hybrid source of energy supply scheme is disclosed. The system includes a first circuit configured to transmit and receive electromagnetic waves, where the first circuit is configured to operate in one of a plurality of operation modes, where the plurality of operation modes includes a normal operation mode, an energy harvesting mode, and a sleep mode. The system further includes a second circuit coupled to the first circuit and configured in one of the plurality of operation modes. The second circuit includes at least one of a receiver or a transmitter, and a third circuit coupled to the first circuit and the second circuit. The third circuit configured to the normal operation mode when the first circuit is configured in the normal operation mode and the second circuit is configured in a normal operation mode.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: February 19, 2019
    Assignee: SPATIALLINK CORPORATION
    Inventors: Qiang Li, Ming Yu Lin
  • Patent number: 10206572
    Abstract: Systems and methods for monitoring of biometric and contextual variables to assist in screening for, quantification of, and prediction of smoking behavior, and for assisting in smoking cessation are described.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: February 19, 2019
    Assignee: Carrot, Inc.
    Inventors: David S. Utley, Allen Jameson, Jennifer Marler
  • Patent number: 10194868
    Abstract: Methods and apparatuses for determining an analyte value are disclosed.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: February 5, 2019
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Erwin Satrya Budiman
  • Patent number: 10198555
    Abstract: A method and apparatus implements patient data downloading for multiple different meter types, such as multiple different blood glucose meters. A plurality of serial ports is provided, each arranged for connection to a respective meter of the multiple different meter types. Information is displayed and user selections are identified. Responsive to user entry identifying a particular meter type, a connection port/cable number for the meter connection is displayed for viewing by the user. Predefined instructions for the particular meter type are displayed. A data collection computer system is provided as an integral unit including a unitary housing containing a processor device, a printer, and a display touch screen. When a meter connection is identified, information is displayed, patient data is downloaded from the meter and is printed in a selected format together with selected reports generated from the downloaded patient data.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: February 5, 2019
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventors: Brian C. Thompson, Joseph E. Ruggiero, Richard A. Lett
  • Patent number: 10195404
    Abstract: A chest drainage system, including a circulation assembly having an intake for taking fluid into the system and an exhaust for exhausting fluid out of the system. An intake flow device is configured to selectively control fluid flow through the intake and an exhaust flow device is configured to selectively controlling fluid flow through the exhaust. The circulation assembly has a first configuration and a second configuration such that transitioning between the first and second configurations during operation of the circulation assembly displaces at least a portion of fluid within the system with fluid from outside the system via the intake and the exhaust. A sensor is arranged in fluid communication with the fluid within the system and configured to detect a concentration of a reference fluid in the fluid in the system.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: February 5, 2019
    Assignee: ATRIUM MEDICAL CORPORATION
    Inventors: Wolfram Grziwa, Greg Peatfield
  • Patent number: 10169971
    Abstract: In some embodiments, apparatuses, systems, and methods are provided herein useful to detecting a deviation in a person's activity. In some embodiments, an apparatus comprises one or more sensors, the one or more sensors configured to monitor parameters associated with a person and the person's home, and a control circuit, the control circuit communicatively coupled to the one or more sensors and configured to receive, from the one or more sensors, values associated with the parameters, create, based on the values associated with the parameters, a spectral profile for the person, determine, based on the spectral profile and a routine base state for the person, that a combination of the values indicates a deviation, determine, based on the deviation, an alert, and cause transmission of the alert.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: January 1, 2019
    Assignee: Walmaty Apollo, LLC
    Inventors: Bruce W. Wilkinson, Todd D. Mattingly
  • Patent number: 10159779
    Abstract: A combination of an AV shunt for hemodialysis patients and a protective sleeve that protects the shunt and the shunt site. The sleeve includes a clear window and technology to monitor and detect a weakening pulse, allowing for early intervention before more serious problems develop.
    Type: Grant
    Filed: May 6, 2018
    Date of Patent: December 25, 2018
    Inventor: Antionette Olivarez
  • Patent number: 10149635
    Abstract: Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, the approach disclosed here enables vital sign monitoring internally from the gastrointestinal tract. The large animal (porcine) experiments and a robust processing disclosed herein demonstrate the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: December 11, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Albert Joseph Swiston, Robert S. Langer, Tadd Bernard Hughes, Kerry Johnson, Carlo Giovanni Traverso
  • Patent number: 10143409
    Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: December 4, 2018
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Gary Alan Hayter
  • Patent number: 10119956
    Abstract: Methods for data processing and control for a medical communication system are provided, including determining a sensitivity value for each sensor of a batch of in vivo analyte sensors; determining a sensitivity variation for each sensor of the batch; determining a mean sensitivity based on the sensitivity value determined for each sensor of the batch when it is determined that the determined sensitivity variation does not exceed a tolerance threshold level; associating a sensor code with each sensor of the batch of in vivo analyte sensors when the mean sensitivity is within a predetermined sensitivity range, wherein the sensor code associated with each sensor is based on a characteristic of the associated sensor; and storing the sensor code associated with at least one sensor of the batch configured to generate signals corresponding to monitored analyte level in a memory of a data processing device associated with the sensor.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: November 6, 2018
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Gary Alan Hayter, Geoffrey V. McGarraugh, Andrew H. Naegeli, John Charles Mazza, Benjamin Jay Feldman
  • Patent number: 10117989
    Abstract: The subcutaneous injection device contains a pump and a mechanism for inserting a cannula into the patient's skin. The cannula is fixedly positioned relative to the pump and the insertion mechanism has a flexible surface adhering to the skin. The flexible surface is positioned relative to the cannula in such a way that in a first position the tip of the cannula is concealed by the surface and in a second position the cannula is exposed beyond the surface. The insertion mechanism brings the surface from the first to the second position, thereby pulling the skin against the tip of the cannula.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: November 6, 2018
    Assignee: PharmaSens AG
    Inventors: Pual Hadvary, Hansjorg Tschirky
  • Patent number: 10111609
    Abstract: The invention relates to a method for detecting a malfunction of a sensor for measuring an analyte concentration in vivo, wherein a series of measurement signals is produced by means of the sensor, and a value of a noise parameter is continually determined from the measuring signals, the noise parameter indicating how severely the measurement is impaired by interference signals. According to the invention, continually determined values of the noise parameter are used to determine how quickly the noise parameter changes, and the rate of change of the noise parameter is evaluated to detect a malfunction.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: October 30, 2018
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Guenther Schmelzeisen-Redeker, Arnulf Staib, Hans-Martin Kloetzer
  • Patent number: 10102405
    Abstract: An electromagnetic coupling reader may include: an antenna, a management module, and a supervision unit, the supervision unit comprising a sleep mode configured to limit energy consumption, a first wake-up signal enabling the supervision unit to be extracted from the sleep mode, the management module comprising an energy saving mode consisting of measuring, at regular intervals, an impedance of the antenna in order to detect a presence of a peripheral authorizing an electromagnetic coupling, the wake-up signal being activated by the management module when a peripheral is detected, the electromagnetic coupling reader comprising a second wake-up signal controlled by a clock configured to extract the supervision unit from the sleep mode at regular intervals.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: October 16, 2018
    Assignee: DURA AUTOMOTIVE SYSTEMS SAS
    Inventor: Eric Durand
  • Patent number: 10092228
    Abstract: A wearable optical device is described for optically detecting parameters of interest within muscle, such as during physical activity or when at rest. The parameters of interest include oxygenation level and/or hemoglobin concentrations in some situations. The detected parameters, such as oxygenation level, may be used to assess physical performance, such as the extent to which the muscle is utilizing aerobic or anaerobic processes. Methods for determining the parameters of interest, such as oxygenation level, from the detected optical signals are also described, and feedback may be provided to a user.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: October 9, 2018
    Assignee: Dynometrics Inc.
    Inventors: Daniel Wiese, Alessandro Babini, Sebastian Trousil, Samuel Huberman, Stefan Kalchmair, Pamela G. Anderson
  • Patent number: 10085695
    Abstract: The present invention relates to a mental balance or imbalance estimation system (100) and method for estimating a level of mental balance or imbalance of a user (1). The system comprises a skin conductance sensor (20) for sensing the skin conductance of the user (1), the skin conductance over time forming a skin conductance trace (22). The system further comprises a processing unit (10) for receiving and processing the skin conductance trace (22), the processing unit configured to determine at least one stimulus response (24) in the skin conductance trace (22), to determine an estimated cortisol level trace (28) of the user (1) based on the determined at least one stimulus response (24), and to determine the estimated level of mental balance or imbalance of the user (1) based on the estimated cortisol level trace (28).
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: October 2, 2018
    Assignee: Koninklijke Philips N.V.
    Inventors: Martin Ouwerkerk, Joanne Henriette Desiree Monique Westerink, Tatiana Aleksandrovna Lashina, Leszek Holenderski
  • Patent number: 10070810
    Abstract: An automatic sensor inserter is disclosed for placing a transcutaneous sensor into the skin of a living body. According to aspects of the invention, characteristics of the insertion such as sensor insertion speed may be varied by a user. In some embodiments, insertion speed may be varied by changing an amount of drive spring compression. The amount of spring compression may be selected from a continuous range of settings and/or it may be selected from a finite number of discrete settings. Methods associated with the use of the automatic inserter are also covered.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: September 11, 2018
    Assignee: ABBOTT DIABETES CARE INC.
    Inventor: Gary Ashley Stafford
  • Patent number: 10071218
    Abstract: An apparatus and method for resuscitating a patient suffering from cardiac arrest or another condition in which normal circulation has been interrupted. A ventilator is used for delivering a gas mixture to the patient. The ventilator is configured to adjust the partial pressure of CO2 to one or more partial pressures high enough to slow expiration of CO2 from the patient's lungs and thereby maintain a reduced pH in the patient's tissues for a period of time following return of spontaneous circulation.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: September 11, 2018
    Assignee: ZOLL Medical Corporation
    Inventors: Gary A. Freeman, Annemarie Silver
  • Patent number: 9993167
    Abstract: A delivery and fixation system of an implant assembly having an intracorporeal device. The system provides for a low profile delivery system for an implant assembly having an anchor for fixation within a vessel adapted to be delivered via a catheter.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: June 12, 2018
    Assignee: St. Jude Medical Luxenbourg Holdings II S. A. R. L (“SJM LUX II”)
    Inventors: Jason White, Jin Woo Park
  • Patent number: 9986923
    Abstract: What is disclosed is a system and method for selecting a region of interest for extracting physiological parameters from a video of a subject. In one embodiment the present method involves performing the following. First, time-series signals are received which have been generated by having processing image frames of a video of a subject captured using a single band video camera with a bandpass filter with a pass band in a wavelength range of 495-565 nm and/or 800-1000 nm. The regions of interest are areas where a plethysmographic signal can be detected by the camera. Each time-series signal is associated with a different region of interest. A signal strength is then calculated for each of the time-series signals. The region associated with the time-series signal having a highest signal strength is selected. The time-series signal associated with the selected region can be processed to extract a videoplethysmographic (VPG) signal containing physiological parameters.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: June 5, 2018
    Assignee: Xerox Corporation
    Inventors: Lalit Keshav Mestha, Martin Edward Hoover, Survi Kyal
  • Patent number: 9987427
    Abstract: The present invention is directed to devices, systems, and methods for detecting and/or monitoring one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: June 5, 2018
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Ronen Polsky, Philip Rocco Miller, Thayne L. Edwards
  • Patent number: 9978289
    Abstract: Communication device for primates, in particular persons, including at least one electrically conductive first surface to be touched by a first primate, at least one electrically conductive second surface to be touched by at least one second primate, and at least primary electronic circuit electrically connecting said first surface and said second, said primary electronic circuit having: at least one detection element for measuring at least one resistance value of a secondary electronic circuit formed by at least the primary electronic circuit, a first primate touching said first surface, at least one second primate touching said second surface, and the first primate and the other least second primate touching each other, and at least one output for producing a specific signal representing the specific resistance value detected by said at least one detection element.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: May 22, 2018
    Assignee: MERGENT B.V.
    Inventors: Dennis Emile Armand Schuivens, Shih Chien Chen
  • Patent number: 9962091
    Abstract: A continuous glucose monitoring system including a sensor configured to detect one or more glucose levels, a transmitter operatively coupled to the sensor, the transmitter configured to receive the detected one or more glucose levels, the transmitter further configured to transmit signals corresponding to the detected one or more glucose levels, and a receiver operatively coupled to the transmitter configured to receive transmitted signals corresponding to the detected one or more glucose levels, and methods thereof, are disclosed. In one aspect, the transmitter may be configured to transmit a current data point and at least one previous data point, the current data point and the at least one previous data point corresponding to the detected one or more glucose levels.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: May 8, 2018
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Robert Y. Jin, Mark Kent Sloan
  • Patent number: 9943256
    Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: April 17, 2018
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Andrea Varsavsky, Xiaolong Li, Mike C. Liu, Yuxiang Zhong, Ning Yang
  • Patent number: 9936906
    Abstract: One variation of the method for managing blood loss of a patient includes: receiving an image of a physical sample; extracting a feature from an area of the image corresponding to the physical sample; estimating a blood volume indicator of the physical sample according to the extracted feature; estimating a patient blood loss based on the blood volume indicator; estimating a euvolemic patient hematocrit based on an estimated patient blood volume and the estimated patient blood loss; receiving a measured patient hematocrit; and generating a volemic status indicator based on a comparison between the measured patient hematocrit and the estimated euvolemic patient hematocrit.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: April 10, 2018
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Ali Zandifar, Kevin J Miller
  • Patent number: 9936910
    Abstract: Methods, systems and devices for providing improved calibration accuracy of continuous and/or in vivo analyte monitoring systems based at least in part on insulin delivery information are provided. Many of the embodiments disclosed herein can determine appropriate conditions for performing a calibration of the analyte sensor in view of the scheduled delivery of insulin or administered insulin amount. One or more other parameters or conditions can also be incorporated to improve calibration accuracy including, for example, the physiological model associated with a patient, meal information, exercise information, activity information, disease information, historical physiological condition information, as well as other types of information. Furthermore, according to some embodiments, calibration of the analyte sensor can be delayed or not performed at all, if appropriate conditions are not met.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: April 10, 2018
    Assignee: ABBOTT DIABETES CARE INC.
    Inventors: Gary Alan Hayter, Erwin Satrya Budiman
  • Patent number: 9931035
    Abstract: In one implementation, an apparatus estimates body core temperature from an infrared measurement of an external source point using a cubic relationship between the body core temperature and the measurement of an external source point is described, estimates temperature from a digital infrared sensor and determines vital signs from a solid-state image transducer, or determines vital signs from a solid-state image transducer and estimates body core temperature from an infrared measurement of an external source point using a cubic relationship between the body core temperature and the measurement of an external source point; after which the estimated and/or determined information is transmitted to an external database.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: April 3, 2018
    Assignee: Arc Devices, LTD
    Inventors: Irwin Gross, Michael G. Smith, Mark Khachaturian, Martin Crawley, Steven Gerst, John Barrett, Michael Cronin, Derek Turnbull, Jason Bodnick
  • Patent number: 9933347
    Abstract: A method and system for determining a density of a fluid is provided. The method is carried out using an electrospraying apparatus connected in the system. At a first step fluid is introduced into an emitter of the electrospraying apparatus. A voltage is applied between the emitter and a counter-electrode spaced apart from the emitter for a number of intermittent time periods, wherein the duration of at least some of the time periods during which the voltage is applied progressively decreases. The current between the emitter and the counter-electrode is measured for each time period during which a voltage is applied and the shortest time period for which a current reading is obtained is recorded. The shortest time period is used to calculate the density of the fluid in the emitter.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: April 3, 2018
    Assignee: Stellenbosch University
    Inventor: Cornelius Louwrens Pieterse
  • Patent number: 9933684
    Abstract: One embodiment provides an apparatus for displaying an image comprising: a first optical substrate comprising at least one waveguide layer configured to propagate light in a first direction, wherein the at least one waveguide layer of the first optical substrate comprises at least one grating lamina configured to extract the light from the first substrate along the first direction; and a second optical substrate comprising at least one waveguide layer configured to propagate the light in a second direction, wherein the at least one waveguide layer of the second optical substrate comprises at least one grating lamina configured to extract light from the second substrate along the second direction; wherein the at least one grating lamina of at least one of the first and second optical substrates comprises an SBG in a passive mode.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: April 3, 2018
    Assignees: Rockwell Collins, Inc., SBG Labs, Inc.
    Inventors: Robert D. Brown, Alastair John Grant, Wyatt L. Hendrick, Milan Momcilo Popovich, James H. Stanley, Jonathan David Waldern
  • Patent number: 9925319
    Abstract: Methods and apparatuses for detection of gas bubbles in a microchannel configured for a conductive fluid to flow therethrough. The methods and apparatuses utilize a plate and at least two aligned electrodes embedded within the plate. The plate is configured to be located over the microchannel such that the at least two aligned electrodes are located along a length of the microchannel in the flow direction. Impedance is measured between the electrodes, and the percentage of gas within the fluid flowing through the microchannel is measured based on the measured impedance between the electrodes.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: March 27, 2018
    Assignee: Purdue Research Foundation
    Inventors: Pierre Valiorgue, Justin A. Weibel, Suresh V. Garimella
  • Patent number: 9918668
    Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: March 20, 2018
    Assignee: DexCom, Inc.
    Inventors: Jack Pryor, Apurv Ullas Kamath, Paul V. Goode, Jr., James H. Brauker
  • Patent number: 9918665
    Abstract: A transdermal permeant delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.
    Type: Grant
    Filed: January 3, 2014
    Date of Patent: March 20, 2018
    Assignee: Nitto Denko Corporation
    Inventors: Stuart McRae, Wendy E. Bowerman, Stephen Wilson Braun, Regina Spiehl, Bernadette Messier, David Farquhar, Erin Koch Henkel, Jeremiah Peter O'Leary, Mark James Fisher, Uros Kascak, Loren J. Lantz, Zoran Novakovic, Jonathan Eppstein
  • Patent number: 9913604
    Abstract: In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: March 13, 2018
    Assignee: OptiScan Biomedical Corporation
    Inventors: James R. Braig, Peter Rule
  • Patent number: 9913628
    Abstract: A method for classifying a tissue sample of a biopsy specimen includes receiving a signal from at least one location of the tissue sample including a plurality of chromophores. Further, the method includes verifying whether the received signal comprises a predetermined amount of at least one of an attenuated illumination light and a re-emitted light. Also, the method includes determining that a spectrum of the received signal is within a predetermined range. In addition, the method includes processing the spectrum of the received signal to decompose the signal into a plurality of components. Furthermore, the method includes classifying tissue in the at least one location of the tissue sample into one of a plurality of tissue types based on the plurality of components.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: March 13, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Siavash Yazdanfar, Victor Petrovich Ostroverkhov, Dmitry Vladimirovich Dylov, Stephen B. Solomon, Jeremy C. Durack
  • Patent number: 9907503
    Abstract: Provided are sensor systems and methods for detecting analytes of bodily fluids. The systems can be used to reduce the administration volume of certain compounds and/or fluids during medical monitoring or other procedures by providing a calibration path configured to receive a first fluid, a sample path isolated from the calibration path, the sample path configured to receive a bodily fluid from a subject, and a sensor apparatus comprising at least one sensor selectively positionable between the calibration path and the sample path.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: March 6, 2018
    Assignee: Edwards Lifesciences Corporation
    Inventor: Mark A. Konno
  • Patent number: 9888932
    Abstract: A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: February 13, 2018
    Assignee: VAXXAS PTY LIMITED
    Inventor: Mark Anthony Fernance Kendall
  • Patent number: 9877673
    Abstract: Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir where the biological sample may chemically react with a biologically reactive element. A sensor may convert the produced electrons (ions) into measured electrical signals. The converted signals may be measured and the levels of an analyte may be determined based on the measured signals.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: January 30, 2018
    Assignee: CLINITECH, LLC
    Inventors: John F. Currie, Joseph A. Marcanio, Joseph J. Vidalis, Sundar B. Nadarajan
  • Patent number: 9867560
    Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: January 16, 2018
    Assignee: Profusa, Inc.
    Inventors: Soya Gamsey, Natalie Wisniewski, Kristen Helton, William McMillan
  • Patent number: 9858887
    Abstract: A display arrangement for e.g. a medical substance delivery device includes a movable control member, at least one transducer responsive to movement of the control member to convert mechanical energy into electrical energy to output an electrical signal, a drive circuit for receiving the electrical signal and for outputting an output drive signal, and a display device for receiving the output drive signal and displaying a variable image that varies consequent on the relative movement. The display may be a bistable display, so that the display function is self-powered without a requirement for a battery or the like. The parameter displayed for a medical substance delivery device may be a dose volume, a count of doses delivered, progress and/or completion of a dose. The drive circuit is an absolute position encoder and detects the actual position of the control member and does not deduce the position by counting pulses.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: January 2, 2018
    Assignee: OWEN MUMFORD LIMITED
    Inventors: Toby Cowe, Cosimo Santella
  • Patent number: 9848804
    Abstract: A sensor insertion device for inserting a detection element of a sensor configured to measure biological information of a subject into the body of the subject includes a device body; a data process unit attached to the device body, a movement mechanism detachably attached to the device body, the movement mechanism being configured to move the detection element together with an insertion needle configured to be stuck into the body of the subject to insert the detection element and the insertion needle into the body of the subject; and a displacement preventing member.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: December 26, 2017
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Takahiro Ohkoshi, Atsushi Matsumoto
  • Patent number: 9833181
    Abstract: Method and apparatus for providing calibration of analyte sensor including applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured response is provided.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: December 5, 2017
    Assignee: Abbot Diabetes Care Inc.
    Inventors: Gary Alan Hayter, Kenneth J. Doniger, Erwin Satrya Budiman, Songbiao Zhang, John Charles Mazza
  • Patent number: 9829464
    Abstract: A liquid sampling device for use with a mobile device comprises a wired connection for connecting the liquid sampling device to the mobile device, a sample receiving and testing section capable of receiving a liquid sample and conducting electrochemical testing of the liquid sample and a sample testing circuit configured to communicate at least one liquid sample test result to the mobile device via the wired connection. Associated methods and a mobile device application for interfacing with the liquid sampling device are also disclosed.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: November 28, 2017
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gang Logan Liu, Manas Ranjan Gartia, Te-Wei Chang, Xinhao Wang, Jing Jang