Perfusion Detection Patents (Class 600/363)
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Patent number: 11599215Abstract: A display device, including a substrate; a pixel electrode and an opposing electrode on the substrate; an encapsulation portion on the opposing electrode, the encapsulation portion including at least one organic layer and at least one inorganic layer alternately deposited; and a planarization layer on the encapsulation portion, the planarization layer including a portion covering an edge portion of the encapsulation portion, a first angle between an edge side surface of the planarization layer and a surface of the substrate being larger than a second angle between an edge side surface of the encapsulation portion and the surface of the substrate.Type: GrantFiled: September 20, 2021Date of Patent: March 7, 2023Assignee: Samsung Display Co., Ltd.Inventors: Yong-Hwan Park, Mi Young Kim, Chi Wook An, Seong Jun Lee
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Patent number: 11439143Abstract: A temperature sensor for monitoring an organ or tissue is configured to measure a temperature inside of a container configured to contain the organ or tissue. The temperature sensor is disposed exterior to the organ container and the temperature sensor is a non-contact temperature sensor. The temperature sensor may be part of an apparatus for perfusing, transporting, and/or storing an organ or tissue. A coolant container may have an aperture through which the temperature sensor measures a temperature of at least one of the organ or tissue or a perfusate fluid surrounding the organ or tissue. The temperature sensor is preferably an infrared temperature sensor. Multiple temperature sensors may be provided that measure the temperature organ or tissue or perfusate fluid surrounding the organ or tissue, for example in case one of the temperature sensors fails.Type: GrantFiled: July 10, 2012Date of Patent: September 13, 2022Assignee: LIFELINE SCIENTIFIC, INC.Inventors: David Kravitz, Christopher P. Steinman, David Pettinato, Richard K. Buck, John Stark, Robert J. Allen
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Patent number: 11161253Abstract: An apparatus, according to one embodiment, includes: an electromagnetic shaft, an expandable balloon coupled to a first end of the shaft, and a fluid reservoir. A conduit also extends between the fluid reservoir and an interior of the balloon. The apparatus also includes a selectively magnetizable fluid, at least a portion of which is contained in the fluid reservoir, and a pump for selectively transferring the magnetizable fluid from the fluid reservoir to the balloon. A pressure sensor for detecting a pressure of the magnetizable fluid, and a controller for controlling the pump are further included. Moreover, at least a portion of the shaft is flexible. Other systems, methods, and computer program products are described in additional embodiments.Type: GrantFiled: May 31, 2019Date of Patent: November 2, 2021Assignee: International Business Machines CorporationInventors: Junfeng Xu, Albert Dennes, Gregory Michael Ketterer, Dave Bach
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Patent number: 10217066Abstract: Methods and apparatus to monitor work vehicles and to generate worklists to order the repair of such work vehicles should a machine failure be identified are disclosed. An apparatus includes an interface to access a first and second alerts from first and second work vehicle; an alert scorer to generate first and second scores for the respective first and second alerts; a machine health score determiner to determine first and second machine health score for the respective first and second work vehicles based on the first score and the first weighting factor and the second score and the second weighting factor; and a worklist generator to generate a worklist indicating that the second work vehicle is to be repaired prior to the first work vehicle based on at least one of the first and second machine health scores or an associated first and second classifications.Type: GrantFiled: August 28, 2017Date of Patent: February 26, 2019Assignee: DEERE & COMPANYInventors: Robert Margherio, Brian Orwig, Ann Patting, Joey W. Schulz, Vivek K. Sinha
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Patent number: 9949682Abstract: The present invention provides a method for determining a target of alcohol test, including: determining whether a motor vehicle satisfies a preset condition; and determining, as a target vehicle, a motor vehicle that satisfies at least one preset condition. The preset condition comprises at least one of: a parking duration in an area, in which a distance from a place selling alcoholic drinks does not exceed a predetermined distance, has a value within a predetermined range; alcohol content in a body of a driver of the motor vehicle exceeds a predetermined value; and schedule of a driver of the motor vehicle on that driving day comprises having a meal and/or a dinner party. The present invention further provides a driving safety device, a server and a driving safety system.Type: GrantFiled: March 29, 2016Date of Patent: April 24, 2018Assignees: BOE TECHNOLOGY GROUP CO., LTD., BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD.Inventor: Xuebo Zhang
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Patent number: 9254220Abstract: The present invention provides a system for assessing the severity and stage of PAD including at least one sensor that measures skin perfusion pressure; a knowledge base that provides data on lower extremity angiosomes; and a processing device in operable communication with the sensor and the knowledge base, the processing device that outputs a visual representation of at least one of the lower extremity angiosomes that guides the sensor in the mapping of a testing site relative to a target vessel where the skin perfusion pressure measurement will be taken.Type: GrantFiled: October 18, 2012Date of Patent: February 9, 2016Assignee: VASAMED, INC.Inventors: Paulita M. LaPlante, Daniel J. Bartnik, Rose A. Griffith
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Patent number: 9031641Abstract: A medical device system and associated method to control a laser Doppler unit to emit light from a coherent laser light source and collect a photodetector signal produced by the laser Doppler unit by a signal processor comprising a bandpass filter. The bandpass filter is applied to the photodetector signal to determine a tissue perfusion measurement from the filtered signal. A monitoring unit is enabled to receive the tissue perfusion measurement to detect a physiological condition of the patient in response to the tissue perfusion measurement.Type: GrantFiled: July 28, 2011Date of Patent: May 12, 2015Assignee: Medtronic, Inc.Inventors: Vinayakrishnan Rajan, Raphael Alexander Schneider
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Patent number: 8983570Abstract: The invention relates to methods for the diagnosis, amelioration, and treatment of back pain, particularly lumbar back pain, in particular, back pain caused by muscular abnormalities, vertebral body osteoporosis, and disc degeneration. Patients with back pain are categorized into specific subsets that are deemed to have potential to respond to therapy. In particular, the invention includes a therapy involving stimulation of neovascularization so as to increase perfusion of various spine compartments.Type: GrantFiled: March 24, 2008Date of Patent: March 17, 2015Assignee: Cardiovascular Biotherapeutics, Inc.Inventors: Thomas J. Stegmann, Kenneth A. Thomas, John W. Jacobs, Tugan Muftuler, Shadfar Bahri, Hon Yu, Vance Gardner
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Patent number: 8971600Abstract: An ultrasonic diagnostic apparatus is provided for displaying a color map on which a difference in blood flow dynamics is reflected. Setting a test subject who is administered a contrast agent is assumed as an imaging target, and a probe transmits and receives ultrasonic waves to and from the target for contrast imaging. Image data is constructed based on signals received by the probe and a time-intensity curve is generated from intensity values of the image data. According to the time-intensity curve, a value of a predetermined parameter is calculated for producing a distribution image of blood flow dynamics. The distribution image (color map) of the blood flow dynamics is produced from the parameter value. The color map is a two-dimensional or a three-dimensional image being color-coded according to the parameter value.Type: GrantFiled: April 7, 2010Date of Patent: March 3, 2015Assignee: Hitachi Medical CorporationInventors: Hideki Yoshikawa, Takashi Azuma
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Patent number: 8965488Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.Type: GrantFiled: March 25, 2013Date of Patent: February 24, 2015Assignee: Novadaq Technologies Inc.Inventors: Peter Dvorsky, David Mark Henri Goyette, T. Bruce Ferguson, Jr., Cheng Chen
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Patent number: 8929974Abstract: In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.Type: GrantFiled: April 8, 2010Date of Patent: January 6, 2015Assignee: Carl Zeiss Meditec AGInventors: Christoph Hauger, Werner Nahm, Theo Lasser, Marcel Leutenegger, Erica Martin-Williams, Antonio Lopez
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Patent number: 8768031Abstract: A method is disclosed of providing time dependent three dimensional imaging of a region of a patient comprising blood vessels in a perfusion bed.Type: GrantFiled: September 30, 2011Date of Patent: July 1, 2014Assignees: Mistretta Medical, LLC, CMS Medical, LLCInventors: Charles A. Mistretta, Charles M. Strother
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Patent number: 8728059Abstract: The disclosed embodiments relate to a system and method for assuring validity of monitoring parameters in combination with a therapeutic device. An exemplary embodiment of the present technique comprises perturbing a treatment administered to a patient, measuring at least one parameter of the patient reflecting the underlying physiological state and associated with the treatment, and comparing the perturbations of the treatment to measurements of the at least one parameter to determine if the perturbations to the treatment are reflected by the parameter.Type: GrantFiled: September 29, 2006Date of Patent: May 20, 2014Assignee: Covidien LPInventors: Edward Karst, Clark R. Baker, Jr.
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Patent number: 8721565Abstract: A device for tissue characterization, comprises a structure; a first mechanism, associated with the structure, configured for exerting a first force on a tissue, for fixing the tissue to the structure, so as to substantially immobilize the tissue; and a second mechanism, associated with the structure, configured for pressing a sensor against an external surface of the immobilized tissue, thereby exerting a second force on the immobilized tissue, wherein at least a component of the first force is in opposition to at least a component of the second force, forcing the immobilized tissue against the sensor, and forcing the sensor against the immobilized tissue, bringing about an effective contact between the sensor and the immobilized tissue.Type: GrantFiled: August 4, 2005Date of Patent: May 13, 2014Assignee: Dune Medical Devices Ltd.Inventors: Dan Hashimshony, Gil Cohen, Iddo Geltner
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Publication number: 20140033332Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.Type: ApplicationFiled: July 25, 2013Publication date: January 30, 2014Inventor: Per-Olof Berggren
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Publication number: 20140018649Abstract: The present invention relates to a system for measuring a micro-vascular flow distribution of a tissue portion of a mammal comprising means (101) for measuring a first indicator (MTT) for the blood flow through a capillary bed, means (102) for measuring a second indicator (CTTH) of heterogeneity of the blood flow in said capillary bed, and a first processor (110) arranged for using the first and the second indicator to estimate an extraction capacity (EC) of a substance from the blood in said capillary bed.Type: ApplicationFiled: March 30, 2012Publication date: January 16, 2014Applicants: REGION MIDTJYLLAND, AARHUS UNIVERSITETInventors: Sune Nørhøj Jespersen, Kim Mouridsen, Leif Østergaard
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Patent number: 8553964Abstract: Methods and a system to unify reconstruction and motion estimation steps in first pass cardiac perfusion MRI include a global objective function that meets data consistency, spatial smoothness, motion and contrast dynamics constraints. The global objective decomposed into simpler sub-problems which include low pass filtering of a deformed object, TV shrinkage, analytical Fourier replacement and an l2 minimizing problem. A registration tool based on the local cross-correlation similarity measure and enabled to perform both rigid and flexile deformations, is applied. Registration parameters are tuned by rigid, semi rigid and flexible models at different stages of iterations. A system to perform the methods is also disclosed.Type: GrantFiled: October 14, 2011Date of Patent: October 8, 2013Assignee: Siemens AktiengesellschaftInventors: Christophe Chefd'hotel, Mathews Jacob, Sajan Goud Lingala, Mariappan S. Nadar, Li Zhang
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Publication number: 20130225958Abstract: An image processing apparatus according to an embodiment includes an acquiring unit, a correcting unit, and a perfusion image creating unit. The acquiring unit obtains a pixel value of a myocardium tissue and an arterial blood before a contrast agent injected in a second contrast examination arrives at a cardiac of a subject when myocardium perfusion data is created, by performing the second contrast examination that captures a second medical image group including the cardiac of the subject who is given an injection of a contrast agent again after a first contrast examination that captures a first medical image group. The correcting unit corrects contrast agent concentrations of an arterial blood and a myocardium tissue in the second medical image group using acquired each pixel value. The perfusion image creating unit computes the myocardium perfusion data in the second contrast examination based on the corrected contrast agent concentrations.Type: ApplicationFiled: April 16, 2013Publication date: August 29, 2013Applicant: Toshiba Medical Systems CorporationInventor: Toshiba Medical Systems Corporation
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Patent number: 8480579Abstract: A high-speed laser perfusion imaging instrument including a laser source, a detector, a signal-processing unit, data memory, and a screen to display results. A section of a sample surface is illuminated with laser light; reemitted light from the irradiated surface is collected by focusing optics on a 2D array of integrating photodetectors having elements that can be accessed individually or in a pre-defined selection of pixels at high speed. This 2D array measures intensity variations at each individual pixel. Average amplitude and mean frequency of the measured signal contain information about concentration and speed of moving blood cells. For real-time imaging, exposure time is used as a parameter to measure relative perfusion changes. These data are stored and processed with the signal-processing unit to deliver 2D flow maps of the illuminated sample section, and allow a simple overlay between a conventional image and processed flow maps.Type: GrantFiled: April 20, 2006Date of Patent: July 9, 2013Assignee: Ecole Polytechnique Fédérale de Lausanne (EPFL)Inventors: Alexandre Serov, Theo Lasser
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Patent number: 8406860Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.Type: GrantFiled: July 22, 2010Date of Patent: March 26, 2013Assignee: Novadaq Technologies Inc.Inventors: Peter Dvorsky, David Mark Henri Goyette, T. Bruce Ferguson, Jr., Cheng Chen
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Publication number: 20130030272Abstract: A probe comprising a tubular member arranged substantially in a plane within a perimeter fitting into the sublingual or postlabial area of a human patient. The tubular member is made preferably of silicone rubber or a material permeable for gases, particularly for carbon dioxide, and forming a barrier against body fluids. The tubular member has consecutive curved sections communicating with each other and form a continuous flow pass. Ends of the tubular member have connection tubes adapted for delivering the fluid inside the lumen of the tubular member directly or indirectly to a measuring apparatus. The connection tubes are made preferably of a material substantially impermeable for carbon dioxide.Type: ApplicationFiled: September 1, 2010Publication date: January 31, 2013Inventor: Domokos Boda
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Patent number: 8165662Abstract: A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, and generates a blood volume index in response to a light source of the plurality of light sources emitting light at an isobestic wavelength. The blood volume index is then utilized to verify the identifying of the cardiac event.Type: GrantFiled: February 28, 2008Date of Patent: April 24, 2012Assignee: Medtronic, Inc.Inventors: Can Cinbis, James K. Carney
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Patent number: 8133177Abstract: A device for assessing capillary vitality comprises an inflatable cuff, a blood flow sensor and a pressure sensor in communication with the cuff, a pressure instrument in fluid communication with the cuff for inflation and deflation thereof, a microprocessor coupled to the pressure instrument for controlling airflow, at least one metabolic sensor for measuring a metabolic condition, and a computer program executable by the microprocessor. The pressure instrument includes a source of pressurized air and a conduit connecting the source of pressurized air to the cuff. The microprocessor is arranged to receive inputs from the blood flow, pressure and metabolic sensors.Type: GrantFiled: January 29, 2008Date of Patent: March 13, 2012Assignee: Vasamed, Inc.Inventors: Paulita LaPlante, Daniel J. Bartnik, Victor Kimball
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Patent number: 8103076Abstract: A method to serially determine changes in perfusion to tissues is provided. This method involves injecting contrast material into a catheter that is positioned in the blood supply proximal to the targeted tissue of interest, acquiring a time series of images that depicts the uptake of this contrast material within the tissue, deriving semi-quantitative or quantitative perfusion metrics based upon the time series of perfusion images, altering perfusion to the targeted tissue by means of injecting pharmacologic agents or embolic agents into the blood vessels supplying the targeted tissue, repeating the acquisition of perfusion images to serially monitor changes in tissue perfusion after each alteration, and calculating changes in perfusion metrics after each series of perfusion images. This method is used to monitor changes in perfusion to various tissues, including a diverse array of tumors.Type: GrantFiled: October 31, 2008Date of Patent: January 24, 2012Assignee: Northwestern UniversityInventors: Andrew Christian Larson, Reed Ali Omary, Dingxin Wang
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Patent number: 7981033Abstract: The invention relates to a tonometric device (20) for examination of respiratory insufficiency and regional tissue perfusion failure in patients, comprising a distal end (22), a section (24) to be introduced into the body, and a fixing part (3). The section (24) to be introduced comprises a first tube (1) to which an additional tubing (4) is connected. A second tube (2) is arranged substantially parallel with the first tube (1). At least the section (24) of the first tube (1) is made of a material permeable for gases, especially for carbon' dioxide, but substantially impermeable for body fluids, preferably of silicone rubber. The device does not comprise any balloon, it can be introduced into the patient stomach without preliminary preparation, and is useful for examination of premature babies.Type: GrantFiled: November 4, 2004Date of Patent: July 19, 2011Assignee: Szegedi TudomanyegyetemInventor: Domokos Boda
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Patent number: 7736311Abstract: An automatic skin perfusion measuring system including instrumentation that automatically analyzes perfusion measurements to identify motion artifact and SPP values and a sensor placement device is provided. The instrumentation is configured to ignore motion artifact. Perfusion measurements are designated as SPP values if various criteria are met. SPP value criteria pertain to factors including cuff pressure, perfusion, perfusion change percentages relative to previous and subsequent perfusion measurements, and whether perfusion measurements are increasing or decreasing relative to previous and subsequent perfusion measurements. The sensor placement device assures reliable data is produced when multiple measurements are desired.Type: GrantFiled: August 29, 2006Date of Patent: June 15, 2010Assignee: Vasamed, Inc.Inventors: Daniel J. Bartnik, Brandon W. Reynolds, Irvin T. Pierskalla
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Publication number: 20100049023Abstract: A non-invasive method of determining a physiological characteristic, comprising providing at least one physiological sensor that is adapted to measure at least one physiological characteristic at a target measurement site on a subject's body, heating an extended tissue region on the subject's body, whereby blood perfusion of the tissue region is enhanced, and measuring at least one physiological characteristic with the physiological sensor during or within a predetermined period after heating the extended tissue region.Type: ApplicationFiled: August 20, 2008Publication date: February 25, 2010Inventors: Bernhard B. Sterling, Andrew R. Lawrence, Gregory I. Voss, James M. Perry, Rankin A. Clinton, III
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Publication number: 20100036217Abstract: The present invention relates, in general, to a system for analyzing tissue perfusion using the concentration of indocyanine green and a method of measuring the perfusion rate using the system and, more particularly, to a system for measuring tissue perfusion by injecting indocyanine green into a living body, detecting variation in the concentration of indocyanine green with the passage of time, and analyzing the detected variation, and a method of measuring the perfusion rate using the system. The present invention provides a method of measuring perfusion in a living body, which enables accurate measurement for respective regions in a wide range from a perfusion rate decreased to less than 10% of normal perfusion to a perfusion rate increased to greater than normal perfusion using the above-described mechanism of ICG in a living body, which cannot be conducted using the conventional technology.Type: ApplicationFiled: July 11, 2007Publication date: February 11, 2010Applicant: Korea Advanced Institute Of Science and TechnologyInventors: Chulhee Choi, Yujung Kang, Myunghwan Choi
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Publication number: 20090326356Abstract: An optical perfusion sensor may monitor blood oxygen saturation of blood-perfused tissue, which may be referred to as tissue perfusion, until a tissue perfusion value is within a threshold range of a reference value, and, in some examples, for at least a minimum period of time. The tissue perfusion value may indicate an absolute blood oxygen saturation level or a relative change in blood oxygen saturation level. The reference value may be, for example, determined by an optical oxygenation (O2) variation index that indicates a change in blood oxygen saturation of tissue. In some examples, an operation of a cardiac signal sensing module may be controlled based upon detecting a threshold change in tissue perfusion. For example, the cardiac signal sensing module may be activated upon detecting a threshold change in tissue perfusion.Type: ApplicationFiled: June 30, 2008Publication date: December 31, 2009Inventor: Stefan G. Kracker
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Patent number: 7618376Abstract: A device is provided for assessing impairment of blood circulation in a patient, such as that in perfusion failure, by measurement of blood flow adjacent a mucosal surface accessible by a mouth or nose and connecting with the gastrointestinal tract or upper respiratory/digestive tract of a patient. The device includes a blood-flow sensor adapted to be positioned adjacent a mucosal surface with a patient's body and measuring blood flow in adjacent tissue and a PCO.sub.2 sensor adapted to be positioned adjacent the mucosal surface and measuring PCO.sub.2. In addition a pH sensor may be used in combination with the blood flow determination. A method of detecting perfusion failure is also disclosed. The method includes utilizing blood-flow measurements in conjunction with a surface perfusion pressure index and/or an optical plethysmography index to more accurately assess perfusion failure. These measurements may also be supplement by taking measurements of pH, sublingual PCO.sub.2, and Sa O.sub.2.Type: GrantFiled: October 26, 2007Date of Patent: November 17, 2009Assignee: Vasamed, Inc.Inventor: Victor E. Kimball
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Publication number: 20090192582Abstract: Implantable cardiac monitoring and stimulation methods and devices with epicardial leads having sensor feedback. A fixed or extendable/retractable sensor may be displaceable within the lead's lumen and configured to sense the presence of an anatomical feature or physiological parameter of cardiac tissue in proximity with the lead body's distal end. The sensor may include an ultrasonic sensing element, a perfusion sensor, a photoplethysmographic sensor, or a blood oximetry sensor. Methods of determining suitability for implanting a lead involve the steps of accessing an epicardial surface of the heart, and moving the cardiac lead to an implant site at the epicardial surface. A transmitted signal is directed at the implant site. A reflected signal is received, indicative of the presence of a blood vessel at the implant site. A determination may be made to determine whether the implant site is suitable or unsuitable based on the reflected signal.Type: ApplicationFiled: March 31, 2009Publication date: July 30, 2009Inventors: Bruce A. Tockman, Randy Westlund
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Publication number: 20080294027Abstract: A perfusion assessment system is proposed.Type: ApplicationFiled: June 25, 2007Publication date: November 27, 2008Inventors: Peter Frinking, Marcel Arditi, Nicolas Rognin
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Publication number: 20080221421Abstract: The present invention relates to an apparatus for measuring the perfusion rate of legs. The measurement apparatus of the present invention includes a light leakage prevention unit including a light emitting device for radiating light having a certain wavelength onto a living body injected with Indocyanine Green (ICG), and a light leakage prevention housing formed to prevent transmission of external light. A data acquisition unit includes a band pass filter for passing therethrough only light, having a near infrared wavelength, in a fluorescence image emitted by the ICG and the light emitting device, and a Charge Coupled Device (CCD) camera for photographing a near infrared wavelength region. A data processing unit calculates a perfusion rate of the living body on a basis of data about the near infrared wavelength region through a data cable connected to the data acquisition unit. A data output unit outputs the perfusion rate calculated by the data processing unit.Type: ApplicationFiled: December 13, 2007Publication date: September 11, 2008Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Chulhee CHOI, Yujung KANG, Myunghwan CHOI
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Publication number: 20080183059Abstract: A device for assessing capillary vitality comprises an inflatable cuff, a blood flow sensor and a pressure sensor in communication with the cuff, a pressure instrument in fluid communication with the cuff for inflation and deflation thereof, a microprocessor coupled to the pressure instrument for controlling airflow, at least one metabolic sensor for measuring a metabolic condition, and a computer program executable by the microprocessor. The pressure instrument includes a source of pressurized air and a conduit connecting the source of pressurized air to the cuff. The microprocessor is arranged to receive inputs from the blood flow, pressure and metabolic sensors.Type: ApplicationFiled: January 29, 2008Publication date: July 31, 2008Applicant: Optical Sensors IncorporatedInventors: Paulita LaPlante, Daniel J. Bartnik, Victor Kimball
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Patent number: 7310548Abstract: The present invention relates to a method of perfusion imaging comprising: performing a first magnetic resonance data acquisition (A) at a first sensitivity (b) value, performing a set of at least six second magnetic resonance data acquisitions (B1, B2, . . . B6) with gradiant encodings in different directions at second sensitivity (b) values, determining a perfusion tensor based on the magnetic resonance data acquisitions, performing a perfusion tensor visualitation step.Type: GrantFiled: March 23, 2004Date of Patent: December 18, 2007Assignee: Koninklijke Philips Electronics N.V.Inventor: Johan Samuel Van Den Brink
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Patent number: 7215988Abstract: The invention relates to a method and a sensor for measurement of tissue perfusion. The sensor is provided with a reservoir (4) for a fluid or gaseous tracer and a tracer-permeable barrier (3), a sub-surface of which is in contact with the surrounding tissue and another sub-surface of which is in contact with a detection cavity (5) which is connected to a suitable apparatus for the measurement of tracer concentration in the detection cavity. The concentration of the tracer in the detection cavity is a measure of perfusion in the surrounding tissue. According to another embodiment of the invention it is also possible to carry out measurements of perfusion in the surface layers of the skin or of an organ.Type: GrantFiled: October 4, 1999Date of Patent: May 8, 2007Inventors: Lars Riis Damgaard, Jens Kristian Gundersen, Lars Hauer Larsen, Thomas Kjaer
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Patent number: 7097618Abstract: Devices and methods for detecting inadequate tissue perfusion by measuring a parameter other than heart rate such as vascular blood pressure, intracardiac blood pressure, vascular blood flow or tissue perfusion, in addition to or as a substitute for heart rate. Such devices and methods improve the accuracy of determining when and to what degree therapy should be administered to treat inadequate tissue perfusion, such as pre-syncope, syncope, or orthostatic hypotension, particularly in the absence of abnormal cardiac function.Type: GrantFiled: March 9, 2004Date of Patent: August 29, 2006Assignee: Transoma Medical, Inc.Inventors: David G. Benditt, Brian P. Brockway, Richard R. Wilson
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Patent number: 6718055Abstract: A medical imaging system includes an imaging device for producing temporally spaced image representations, a memory for storing the image representations, and a processor. The processor aligns the image representations by iteratively deriving a transform between progressively smaller sub-sets of pixels in temporally adjacent images until the sub-sets converge, and, applies the transform to the temporally adjacent images. The processor further sorts selected pixels in a region of interest spatially within each of the image representations for further processing by classifying pixels in the images according to a characteristic indicative of an absorption rate of the contrast agent.Type: GrantFiled: December 5, 2000Date of Patent: April 6, 2004Assignee: Koninklijke Philips Electronics, N.V.Inventor: Jasjit S. Suri
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Publication number: 20030236454Abstract: A microdialysis probe and catheter arrangement includes a catheter carrying in a distal end thereof a probe to be inserted in the body of a living being. The catheter has an elongate catheter body including a first channel for supplying a first fluid and a second channel for returning said first fluid. The first and second channels extend internally along the catheter body from a proximal end thereof to the probe. The probe includes a microdialysis membrane defining a dialysis chamber communicating with the first and second channels. A third channel extends internally along the catheter body and communicates with the second channel to supply a second fluid to thereto, thereby to increase the flow rate therein.Type: ApplicationFiled: June 24, 2002Publication date: December 25, 2003Inventors: Jan Liska, Anders Franco-Cereceda
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Patent number: 6632183Abstract: A technique for quantifying perfusion and removing a biopsy sample at a site in a living body wherein an instrument having a perfusion sensor is introduced into the body at a site to be investigated to there interrogate the tissue. The biopsy specimen is collected when the perfusion sensor produces a signal indicative of perfused, viable tissue.Type: GrantFiled: February 12, 2001Date of Patent: October 14, 2003Assignee: Thermal Technologies, Inc.Inventors: Harry Frederick Bowman, Gregory T. Martin
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Publication number: 20030120139Abstract: An apparatus and method for assuring that a machine operator is not under the influence of a chemical, comprising a first sensor positioned proximally to the machine operator and adapted for measuring a vapor concentration proximal thereto, a second sensor positioned distally from the machine operator and adapted for measuring the vapor concentration distally from the operator, a device for comparing the proximal and distal vapor concentrations, and an automated remediating device responsive to the comparing device when the ratio of the first and the second vapor concentrations are within a specified range.Type: ApplicationFiled: December 26, 2001Publication date: June 26, 2003Inventors: Landon Duval, Ronald Louis Williams
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Patent number: 6488623Abstract: The disclosure relates to a device for determining perfusion capacity in a region of a patient's skin and underlying tissue utilizing a thermoelectric device to create a temperature differential, a sensor for measuring the temperature differential, a controller coupled to the sensor and the thermoelectric device for maintaining the temperature differential substantially constant by providing electrical energy to the thermoelectric device, and measuring the electrical energy provided to the thermoelectric device when the thermoelectric device is positioned adjacent the region of the patient's skin to indicate perfusion capacity.Type: GrantFiled: November 9, 2000Date of Patent: December 3, 2002Assignee: Hill-Rom Services, Inc.Inventors: Ryszard S. Ozarowski, William T. Sutton
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Publication number: 20020007115Abstract: Differentiating breast ducts for cancer risk status is a key element in a procedure to screen women for breast cancer. The 6 to 9 breast ducts on the human breast can be differentiated to identify those of higher risk for cancer. The higher risk ducts merit access and analysis of the ductal fluid and monitoring and/or treatment.Type: ApplicationFiled: May 10, 2001Publication date: January 17, 2002Inventors: David Hung, Susan Love
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Patent number: 6248066Abstract: An apparatus for evaluating perfusion adjacent a skin surface includes a housing having first an second interior regions. The housing is configured to engage the skin surface. The apparatus also includes a plunger located in the first region of the housing for applying pressure to a first zone of the skin surface, a vacuum connection coupled to the second region of the housing to permit suction to be applied to the second region of the housing and to a second zone of the skin surface, a first temperature sensor for generating an output signal related to the temperature of the first zone of the skin surface, a second temperature sensor for generating an output signal related to the temperature of the second zone of the skin surface, and a processor circuit coupled to the first and second temperature sensors for determining a differential temperature between the first and second zones of the skin surface to provide an indication of perfusion adjacent the skin surface.Type: GrantFiled: January 3, 2000Date of Patent: June 19, 2001Assignee: Hill-Rom, Inc.Inventors: Richard I. Barnett, Ryszard S. Ozarowski, William T. Sutton, James M. C. Thomas, William C. Knapp
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Patent number: 6183418Abstract: The process for detection and for quantitative determination of substances emitted or perspired through the skin is derived from flow diffusion analysis. The measuring system conceived for this purpose uses a diffusion half cell through which an acceptor medium flows and which is closed by a membrane. For the duration of the measurement, the membrane is brought into contact with the skin or a closed gas volume formed over the skin. With the process and the related measuring system, the blood alcohol level can be determined with a good degree of precision indirectly via the quantity of (gaseous) ethanol emitted through the skin.Type: GrantFiled: January 30, 1998Date of Patent: February 6, 2001Assignees: Trace Analysensysteme GmbH, Moller Feinmechanik GmbH & Co., META Mebtechnische Systeme GmbHInventor: Wolfgang Kuennecke
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Patent number: 6013029Abstract: The concentration of a substance or group of substances in a body fluid is monitored by means of an interface held in contact with a living human or animal body and a detector is positioned downstream from the interface. A profusion fluid is passed from the interface to and along the detector at a flow rate of less than 60 .mu.l/hour. A constant flow is maintained at the low flow rate with very little or no supply of energy, allowing for a compact construction and reduced measurement delay.Type: GrantFiled: June 6, 1996Date of Patent: January 11, 2000Inventors: Jakob Korf, Thomas Henricus Marie Terwee
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Patent number: 6010455Abstract: An apparatus for evaluating perfusion adjacent a skin surface includes a housing having first and second interior regions. The housing is configured to engage the skin surface. The apparatus also includes a plunger located in the first region of the housing for applying pressure to a first zone of the skin surface, a vacuum connection coupled to the second region of the housing to permit suction to be applied to the second region of the housing and to a second zone of the skin surface, a first temperature sensor for generating an output signal related to the temperature of the first zone of the skin surface, a second temperature sensor for generating an output signal related to the temperature of the second zone of the skin surface, and a processor circuit coupled to the first and second temperature sensors for determining a differential temperature between the first and second zones of the skin surface to provide an indication of perfusion adjacent the skin surface.Type: GrantFiled: June 22, 1998Date of Patent: January 4, 2000Assignee: Hill-Rom, Inc.Inventors: Richard I. Barnett, Ryszard S. Ozarowski, William T. Sutton, James M. C. Thomas, William C. Knapp
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Patent number: 5769784Abstract: An apparatus and method for evaluating perfusion adjacent a skin surface includes the steps of measuring a reference rate of perfusion of the skin surface, storing the reference rate of perfusion, and applying a positive force to the skin surface. The apparatus and method also includes the steps of measuring a second rate of perfusion adjacent the skin surface after the positive force is applied, and calculating a differential rate of perfusion between the reference rate of perfusion and the second rate of perfusion after positive force is applied to provide an indication of perfusion adjacent the skin surface. The apparatus and method further includes the step of displaying the indication of perfusion.Type: GrantFiled: November 27, 1995Date of Patent: June 23, 1998Assignee: Hill-Rom, Inc.Inventors: Richard I. Barnett, Ryszard S. Ozarowski, William T. Sutton, James M. C. Thomas