Perfusion Detection Patents (Class 600/363)
  • Patent number: 10217066
    Abstract: Methods and apparatus to monitor work vehicles and to generate worklists to order the repair of such work vehicles should a machine failure be identified are disclosed. An apparatus includes an interface to access a first and second alerts from first and second work vehicle; an alert scorer to generate first and second scores for the respective first and second alerts; a machine health score determiner to determine first and second machine health score for the respective first and second work vehicles based on the first score and the first weighting factor and the second score and the second weighting factor; and a worklist generator to generate a worklist indicating that the second work vehicle is to be repaired prior to the first work vehicle based on at least one of the first and second machine health scores or an associated first and second classifications.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: February 26, 2019
    Assignee: DEERE & COMPANY
    Inventors: Robert Margherio, Brian Orwig, Ann Patting, Joey W. Schulz, Vivek K. Sinha
  • Patent number: 9949682
    Abstract: The present invention provides a method for determining a target of alcohol test, including: determining whether a motor vehicle satisfies a preset condition; and determining, as a target vehicle, a motor vehicle that satisfies at least one preset condition. The preset condition comprises at least one of: a parking duration in an area, in which a distance from a place selling alcoholic drinks does not exceed a predetermined distance, has a value within a predetermined range; alcohol content in a body of a driver of the motor vehicle exceeds a predetermined value; and schedule of a driver of the motor vehicle on that driving day comprises having a meal and/or a dinner party. The present invention further provides a driving safety device, a server and a driving safety system.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: April 24, 2018
    Assignees: BOE TECHNOLOGY GROUP CO., LTD., BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD.
    Inventor: Xuebo Zhang
  • Patent number: 9254220
    Abstract: The present invention provides a system for assessing the severity and stage of PAD including at least one sensor that measures skin perfusion pressure; a knowledge base that provides data on lower extremity angiosomes; and a processing device in operable communication with the sensor and the knowledge base, the processing device that outputs a visual representation of at least one of the lower extremity angiosomes that guides the sensor in the mapping of a testing site relative to a target vessel where the skin perfusion pressure measurement will be taken.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: February 9, 2016
    Assignee: VASAMED, INC.
    Inventors: Paulita M. LaPlante, Daniel J. Bartnik, Rose A. Griffith
  • Patent number: 9031641
    Abstract: A medical device system and associated method to control a laser Doppler unit to emit light from a coherent laser light source and collect a photodetector signal produced by the laser Doppler unit by a signal processor comprising a bandpass filter. The bandpass filter is applied to the photodetector signal to determine a tissue perfusion measurement from the filtered signal. A monitoring unit is enabled to receive the tissue perfusion measurement to detect a physiological condition of the patient in response to the tissue perfusion measurement.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: May 12, 2015
    Assignee: Medtronic, Inc.
    Inventors: Vinayakrishnan Rajan, Raphael Alexander Schneider
  • Patent number: 8983570
    Abstract: The invention relates to methods for the diagnosis, amelioration, and treatment of back pain, particularly lumbar back pain, in particular, back pain caused by muscular abnormalities, vertebral body osteoporosis, and disc degeneration. Patients with back pain are categorized into specific subsets that are deemed to have potential to respond to therapy. In particular, the invention includes a therapy involving stimulation of neovascularization so as to increase perfusion of various spine compartments.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: March 17, 2015
    Assignee: Cardiovascular Biotherapeutics, Inc.
    Inventors: Thomas J. Stegmann, Kenneth A. Thomas, John W. Jacobs, Tugan Muftuler, Shadfar Bahri, Hon Yu, Vance Gardner
  • Patent number: 8971600
    Abstract: An ultrasonic diagnostic apparatus is provided for displaying a color map on which a difference in blood flow dynamics is reflected. Setting a test subject who is administered a contrast agent is assumed as an imaging target, and a probe transmits and receives ultrasonic waves to and from the target for contrast imaging. Image data is constructed based on signals received by the probe and a time-intensity curve is generated from intensity values of the image data. According to the time-intensity curve, a value of a predetermined parameter is calculated for producing a distribution image of blood flow dynamics. The distribution image (color map) of the blood flow dynamics is produced from the parameter value. The color map is a two-dimensional or a three-dimensional image being color-coded according to the parameter value.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: March 3, 2015
    Assignee: Hitachi Medical Corporation
    Inventors: Hideki Yoshikawa, Takashi Azuma
  • Patent number: 8965488
    Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.
    Type: Grant
    Filed: March 25, 2013
    Date of Patent: February 24, 2015
    Assignee: Novadaq Technologies Inc.
    Inventors: Peter Dvorsky, David Mark Henri Goyette, T. Bruce Ferguson, Jr., Cheng Chen
  • Patent number: 8929974
    Abstract: In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: January 6, 2015
    Assignee: Carl Zeiss Meditec AG
    Inventors: Christoph Hauger, Werner Nahm, Theo Lasser, Marcel Leutenegger, Erica Martin-Williams, Antonio Lopez
  • Patent number: 8768031
    Abstract: A method is disclosed of providing time dependent three dimensional imaging of a region of a patient comprising blood vessels in a perfusion bed.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: July 1, 2014
    Assignees: Mistretta Medical, LLC, CMS Medical, LLC
    Inventors: Charles A. Mistretta, Charles M. Strother
  • Patent number: 8728059
    Abstract: The disclosed embodiments relate to a system and method for assuring validity of monitoring parameters in combination with a therapeutic device. An exemplary embodiment of the present technique comprises perturbing a treatment administered to a patient, measuring at least one parameter of the patient reflecting the underlying physiological state and associated with the treatment, and comparing the perturbations of the treatment to measurements of the at least one parameter to determine if the perturbations to the treatment are reflected by the parameter.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: May 20, 2014
    Assignee: Covidien LP
    Inventors: Edward Karst, Clark R. Baker, Jr.
  • Patent number: 8721565
    Abstract: A device for tissue characterization, comprises a structure; a first mechanism, associated with the structure, configured for exerting a first force on a tissue, for fixing the tissue to the structure, so as to substantially immobilize the tissue; and a second mechanism, associated with the structure, configured for pressing a sensor against an external surface of the immobilized tissue, thereby exerting a second force on the immobilized tissue, wherein at least a component of the first force is in opposition to at least a component of the second force, forcing the immobilized tissue against the sensor, and forcing the sensor against the immobilized tissue, bringing about an effective contact between the sensor and the immobilized tissue.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: May 13, 2014
    Assignee: Dune Medical Devices Ltd.
    Inventors: Dan Hashimshony, Gil Cohen, Iddo Geltner
  • Publication number: 20140033332
    Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
    Type: Application
    Filed: July 25, 2013
    Publication date: January 30, 2014
    Inventor: Per-Olof Berggren
  • Publication number: 20140018649
    Abstract: The present invention relates to a system for measuring a micro-vascular flow distribution of a tissue portion of a mammal comprising means (101) for measuring a first indicator (MTT) for the blood flow through a capillary bed, means (102) for measuring a second indicator (CTTH) of heterogeneity of the blood flow in said capillary bed, and a first processor (110) arranged for using the first and the second indicator to estimate an extraction capacity (EC) of a substance from the blood in said capillary bed.
    Type: Application
    Filed: March 30, 2012
    Publication date: January 16, 2014
    Applicants: REGION MIDTJYLLAND, AARHUS UNIVERSITET
    Inventors: Sune Nørhøj Jespersen, Kim Mouridsen, Leif Østergaard
  • Patent number: 8553964
    Abstract: Methods and a system to unify reconstruction and motion estimation steps in first pass cardiac perfusion MRI include a global objective function that meets data consistency, spatial smoothness, motion and contrast dynamics constraints. The global objective decomposed into simpler sub-problems which include low pass filtering of a deformed object, TV shrinkage, analytical Fourier replacement and an l2 minimizing problem. A registration tool based on the local cross-correlation similarity measure and enabled to perform both rigid and flexile deformations, is applied. Registration parameters are tuned by rigid, semi rigid and flexible models at different stages of iterations. A system to perform the methods is also disclosed.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: October 8, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventors: Christophe Chefd'hotel, Mathews Jacob, Sajan Goud Lingala, Mariappan S. Nadar, Li Zhang
  • Publication number: 20130225958
    Abstract: An image processing apparatus according to an embodiment includes an acquiring unit, a correcting unit, and a perfusion image creating unit. The acquiring unit obtains a pixel value of a myocardium tissue and an arterial blood before a contrast agent injected in a second contrast examination arrives at a cardiac of a subject when myocardium perfusion data is created, by performing the second contrast examination that captures a second medical image group including the cardiac of the subject who is given an injection of a contrast agent again after a first contrast examination that captures a first medical image group. The correcting unit corrects contrast agent concentrations of an arterial blood and a myocardium tissue in the second medical image group using acquired each pixel value. The perfusion image creating unit computes the myocardium perfusion data in the second contrast examination based on the corrected contrast agent concentrations.
    Type: Application
    Filed: April 16, 2013
    Publication date: August 29, 2013
    Applicant: Toshiba Medical Systems Corporation
    Inventor: Toshiba Medical Systems Corporation
  • Patent number: 8480579
    Abstract: A high-speed laser perfusion imaging instrument including a laser source, a detector, a signal-processing unit, data memory, and a screen to display results. A section of a sample surface is illuminated with laser light; reemitted light from the irradiated surface is collected by focusing optics on a 2D array of integrating photodetectors having elements that can be accessed individually or in a pre-defined selection of pixels at high speed. This 2D array measures intensity variations at each individual pixel. Average amplitude and mean frequency of the measured signal contain information about concentration and speed of moving blood cells. For real-time imaging, exposure time is used as a parameter to measure relative perfusion changes. These data are stored and processed with the signal-processing unit to deliver 2D flow maps of the illuminated sample section, and allow a simple overlay between a conventional image and processed flow maps.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: July 9, 2013
    Assignee: Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Alexandre Serov, Theo Lasser
  • Patent number: 8406860
    Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: March 26, 2013
    Assignee: Novadaq Technologies Inc.
    Inventors: Peter Dvorsky, David Mark Henri Goyette, T. Bruce Ferguson, Jr., Cheng Chen
  • Publication number: 20130030272
    Abstract: A probe comprising a tubular member arranged substantially in a plane within a perimeter fitting into the sublingual or postlabial area of a human patient. The tubular member is made preferably of silicone rubber or a material permeable for gases, particularly for carbon dioxide, and forming a barrier against body fluids. The tubular member has consecutive curved sections communicating with each other and form a continuous flow pass. Ends of the tubular member have connection tubes adapted for delivering the fluid inside the lumen of the tubular member directly or indirectly to a measuring apparatus. The connection tubes are made preferably of a material substantially impermeable for carbon dioxide.
    Type: Application
    Filed: September 1, 2010
    Publication date: January 31, 2013
    Inventor: Domokos Boda
  • Patent number: 8165662
    Abstract: A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, and generates a blood volume index in response to a light source of the plurality of light sources emitting light at an isobestic wavelength. The blood volume index is then utilized to verify the identifying of the cardiac event.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: April 24, 2012
    Assignee: Medtronic, Inc.
    Inventors: Can Cinbis, James K. Carney
  • Patent number: 8133177
    Abstract: A device for assessing capillary vitality comprises an inflatable cuff, a blood flow sensor and a pressure sensor in communication with the cuff, a pressure instrument in fluid communication with the cuff for inflation and deflation thereof, a microprocessor coupled to the pressure instrument for controlling airflow, at least one metabolic sensor for measuring a metabolic condition, and a computer program executable by the microprocessor. The pressure instrument includes a source of pressurized air and a conduit connecting the source of pressurized air to the cuff. The microprocessor is arranged to receive inputs from the blood flow, pressure and metabolic sensors.
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: March 13, 2012
    Assignee: Vasamed, Inc.
    Inventors: Paulita LaPlante, Daniel J. Bartnik, Victor Kimball
  • Patent number: 8103076
    Abstract: A method to serially determine changes in perfusion to tissues is provided. This method involves injecting contrast material into a catheter that is positioned in the blood supply proximal to the targeted tissue of interest, acquiring a time series of images that depicts the uptake of this contrast material within the tissue, deriving semi-quantitative or quantitative perfusion metrics based upon the time series of perfusion images, altering perfusion to the targeted tissue by means of injecting pharmacologic agents or embolic agents into the blood vessels supplying the targeted tissue, repeating the acquisition of perfusion images to serially monitor changes in tissue perfusion after each alteration, and calculating changes in perfusion metrics after each series of perfusion images. This method is used to monitor changes in perfusion to various tissues, including a diverse array of tumors.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: January 24, 2012
    Assignee: Northwestern University
    Inventors: Andrew Christian Larson, Reed Ali Omary, Dingxin Wang
  • Patent number: 7981033
    Abstract: The invention relates to a tonometric device (20) for examination of respiratory insufficiency and regional tissue perfusion failure in patients, comprising a distal end (22), a section (24) to be introduced into the body, and a fixing part (3). The section (24) to be introduced comprises a first tube (1) to which an additional tubing (4) is connected. A second tube (2) is arranged substantially parallel with the first tube (1). At least the section (24) of the first tube (1) is made of a material permeable for gases, especially for carbon' dioxide, but substantially impermeable for body fluids, preferably of silicone rubber. The device does not comprise any balloon, it can be introduced into the patient stomach without preliminary preparation, and is useful for examination of premature babies.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: July 19, 2011
    Assignee: Szegedi Tudomanyegyetem
    Inventor: Domokos Boda
  • Patent number: 7736311
    Abstract: An automatic skin perfusion measuring system including instrumentation that automatically analyzes perfusion measurements to identify motion artifact and SPP values and a sensor placement device is provided. The instrumentation is configured to ignore motion artifact. Perfusion measurements are designated as SPP values if various criteria are met. SPP value criteria pertain to factors including cuff pressure, perfusion, perfusion change percentages relative to previous and subsequent perfusion measurements, and whether perfusion measurements are increasing or decreasing relative to previous and subsequent perfusion measurements. The sensor placement device assures reliable data is produced when multiple measurements are desired.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: June 15, 2010
    Assignee: Vasamed, Inc.
    Inventors: Daniel J. Bartnik, Brandon W. Reynolds, Irvin T. Pierskalla
  • Publication number: 20100049023
    Abstract: A non-invasive method of determining a physiological characteristic, comprising providing at least one physiological sensor that is adapted to measure at least one physiological characteristic at a target measurement site on a subject's body, heating an extended tissue region on the subject's body, whereby blood perfusion of the tissue region is enhanced, and measuring at least one physiological characteristic with the physiological sensor during or within a predetermined period after heating the extended tissue region.
    Type: Application
    Filed: August 20, 2008
    Publication date: February 25, 2010
    Inventors: Bernhard B. Sterling, Andrew R. Lawrence, Gregory I. Voss, James M. Perry, Rankin A. Clinton, III
  • Publication number: 20100036217
    Abstract: The present invention relates, in general, to a system for analyzing tissue perfusion using the concentration of indocyanine green and a method of measuring the perfusion rate using the system and, more particularly, to a system for measuring tissue perfusion by injecting indocyanine green into a living body, detecting variation in the concentration of indocyanine green with the passage of time, and analyzing the detected variation, and a method of measuring the perfusion rate using the system. The present invention provides a method of measuring perfusion in a living body, which enables accurate measurement for respective regions in a wide range from a perfusion rate decreased to less than 10% of normal perfusion to a perfusion rate increased to greater than normal perfusion using the above-described mechanism of ICG in a living body, which cannot be conducted using the conventional technology.
    Type: Application
    Filed: July 11, 2007
    Publication date: February 11, 2010
    Applicant: Korea Advanced Institute Of Science and Technology
    Inventors: Chulhee Choi, Yujung Kang, Myunghwan Choi
  • Publication number: 20090326356
    Abstract: An optical perfusion sensor may monitor blood oxygen saturation of blood-perfused tissue, which may be referred to as tissue perfusion, until a tissue perfusion value is within a threshold range of a reference value, and, in some examples, for at least a minimum period of time. The tissue perfusion value may indicate an absolute blood oxygen saturation level or a relative change in blood oxygen saturation level. The reference value may be, for example, determined by an optical oxygenation (O2) variation index that indicates a change in blood oxygen saturation of tissue. In some examples, an operation of a cardiac signal sensing module may be controlled based upon detecting a threshold change in tissue perfusion. For example, the cardiac signal sensing module may be activated upon detecting a threshold change in tissue perfusion.
    Type: Application
    Filed: June 30, 2008
    Publication date: December 31, 2009
    Inventor: Stefan G. Kracker
  • Patent number: 7618376
    Abstract: A device is provided for assessing impairment of blood circulation in a patient, such as that in perfusion failure, by measurement of blood flow adjacent a mucosal surface accessible by a mouth or nose and connecting with the gastrointestinal tract or upper respiratory/digestive tract of a patient. The device includes a blood-flow sensor adapted to be positioned adjacent a mucosal surface with a patient's body and measuring blood flow in adjacent tissue and a PCO.sub.2 sensor adapted to be positioned adjacent the mucosal surface and measuring PCO.sub.2. In addition a pH sensor may be used in combination with the blood flow determination. A method of detecting perfusion failure is also disclosed. The method includes utilizing blood-flow measurements in conjunction with a surface perfusion pressure index and/or an optical plethysmography index to more accurately assess perfusion failure. These measurements may also be supplement by taking measurements of pH, sublingual PCO.sub.2, and Sa O.sub.2.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: November 17, 2009
    Assignee: Vasamed, Inc.
    Inventor: Victor E. Kimball
  • Publication number: 20090192582
    Abstract: Implantable cardiac monitoring and stimulation methods and devices with epicardial leads having sensor feedback. A fixed or extendable/retractable sensor may be displaceable within the lead's lumen and configured to sense the presence of an anatomical feature or physiological parameter of cardiac tissue in proximity with the lead body's distal end. The sensor may include an ultrasonic sensing element, a perfusion sensor, a photoplethysmographic sensor, or a blood oximetry sensor. Methods of determining suitability for implanting a lead involve the steps of accessing an epicardial surface of the heart, and moving the cardiac lead to an implant site at the epicardial surface. A transmitted signal is directed at the implant site. A reflected signal is received, indicative of the presence of a blood vessel at the implant site. A determination may be made to determine whether the implant site is suitable or unsuitable based on the reflected signal.
    Type: Application
    Filed: March 31, 2009
    Publication date: July 30, 2009
    Inventors: Bruce A. Tockman, Randy Westlund
  • Publication number: 20080294027
    Abstract: A perfusion assessment system is proposed.
    Type: Application
    Filed: June 25, 2007
    Publication date: November 27, 2008
    Inventors: Peter Frinking, Marcel Arditi, Nicolas Rognin
  • Publication number: 20080221421
    Abstract: The present invention relates to an apparatus for measuring the perfusion rate of legs. The measurement apparatus of the present invention includes a light leakage prevention unit including a light emitting device for radiating light having a certain wavelength onto a living body injected with Indocyanine Green (ICG), and a light leakage prevention housing formed to prevent transmission of external light. A data acquisition unit includes a band pass filter for passing therethrough only light, having a near infrared wavelength, in a fluorescence image emitted by the ICG and the light emitting device, and a Charge Coupled Device (CCD) camera for photographing a near infrared wavelength region. A data processing unit calculates a perfusion rate of the living body on a basis of data about the near infrared wavelength region through a data cable connected to the data acquisition unit. A data output unit outputs the perfusion rate calculated by the data processing unit.
    Type: Application
    Filed: December 13, 2007
    Publication date: September 11, 2008
    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Chulhee CHOI, Yujung KANG, Myunghwan CHOI
  • Publication number: 20080183059
    Abstract: A device for assessing capillary vitality comprises an inflatable cuff, a blood flow sensor and a pressure sensor in communication with the cuff, a pressure instrument in fluid communication with the cuff for inflation and deflation thereof, a microprocessor coupled to the pressure instrument for controlling airflow, at least one metabolic sensor for measuring a metabolic condition, and a computer program executable by the microprocessor. The pressure instrument includes a source of pressurized air and a conduit connecting the source of pressurized air to the cuff. The microprocessor is arranged to receive inputs from the blood flow, pressure and metabolic sensors.
    Type: Application
    Filed: January 29, 2008
    Publication date: July 31, 2008
    Applicant: Optical Sensors Incorporated
    Inventors: Paulita LaPlante, Daniel J. Bartnik, Victor Kimball
  • Patent number: 7310548
    Abstract: The present invention relates to a method of perfusion imaging comprising: performing a first magnetic resonance data acquisition (A) at a first sensitivity (b) value, performing a set of at least six second magnetic resonance data acquisitions (B1, B2, . . . B6) with gradiant encodings in different directions at second sensitivity (b) values, determining a perfusion tensor based on the magnetic resonance data acquisitions, performing a perfusion tensor visualitation step.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: December 18, 2007
    Assignee: Koninklijke Philips Electronics N.V.
    Inventor: Johan Samuel Van Den Brink
  • Patent number: 7215988
    Abstract: The invention relates to a method and a sensor for measurement of tissue perfusion. The sensor is provided with a reservoir (4) for a fluid or gaseous tracer and a tracer-permeable barrier (3), a sub-surface of which is in contact with the surrounding tissue and another sub-surface of which is in contact with a detection cavity (5) which is connected to a suitable apparatus for the measurement of tracer concentration in the detection cavity. The concentration of the tracer in the detection cavity is a measure of perfusion in the surrounding tissue. According to another embodiment of the invention it is also possible to carry out measurements of perfusion in the surface layers of the skin or of an organ.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: May 8, 2007
    Inventors: Lars Riis Damgaard, Jens Kristian Gundersen, Lars Hauer Larsen, Thomas Kjaer
  • Patent number: 7097618
    Abstract: Devices and methods for detecting inadequate tissue perfusion by measuring a parameter other than heart rate such as vascular blood pressure, intracardiac blood pressure, vascular blood flow or tissue perfusion, in addition to or as a substitute for heart rate. Such devices and methods improve the accuracy of determining when and to what degree therapy should be administered to treat inadequate tissue perfusion, such as pre-syncope, syncope, or orthostatic hypotension, particularly in the absence of abnormal cardiac function.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: August 29, 2006
    Assignee: Transoma Medical, Inc.
    Inventors: David G. Benditt, Brian P. Brockway, Richard R. Wilson
  • Patent number: 6718055
    Abstract: A medical imaging system includes an imaging device for producing temporally spaced image representations, a memory for storing the image representations, and a processor. The processor aligns the image representations by iteratively deriving a transform between progressively smaller sub-sets of pixels in temporally adjacent images until the sub-sets converge, and, applies the transform to the temporally adjacent images. The processor further sorts selected pixels in a region of interest spatially within each of the image representations for further processing by classifying pixels in the images according to a characteristic indicative of an absorption rate of the contrast agent.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: April 6, 2004
    Assignee: Koninklijke Philips Electronics, N.V.
    Inventor: Jasjit S. Suri
  • Publication number: 20030236454
    Abstract: A microdialysis probe and catheter arrangement includes a catheter carrying in a distal end thereof a probe to be inserted in the body of a living being. The catheter has an elongate catheter body including a first channel for supplying a first fluid and a second channel for returning said first fluid. The first and second channels extend internally along the catheter body from a proximal end thereof to the probe. The probe includes a microdialysis membrane defining a dialysis chamber communicating with the first and second channels. A third channel extends internally along the catheter body and communicates with the second channel to supply a second fluid to thereto, thereby to increase the flow rate therein.
    Type: Application
    Filed: June 24, 2002
    Publication date: December 25, 2003
    Inventors: Jan Liska, Anders Franco-Cereceda
  • Patent number: 6632183
    Abstract: A technique for quantifying perfusion and removing a biopsy sample at a site in a living body wherein an instrument having a perfusion sensor is introduced into the body at a site to be investigated to there interrogate the tissue. The biopsy specimen is collected when the perfusion sensor produces a signal indicative of perfused, viable tissue.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: October 14, 2003
    Assignee: Thermal Technologies, Inc.
    Inventors: Harry Frederick Bowman, Gregory T. Martin
  • Publication number: 20030120139
    Abstract: An apparatus and method for assuring that a machine operator is not under the influence of a chemical, comprising a first sensor positioned proximally to the machine operator and adapted for measuring a vapor concentration proximal thereto, a second sensor positioned distally from the machine operator and adapted for measuring the vapor concentration distally from the operator, a device for comparing the proximal and distal vapor concentrations, and an automated remediating device responsive to the comparing device when the ratio of the first and the second vapor concentrations are within a specified range.
    Type: Application
    Filed: December 26, 2001
    Publication date: June 26, 2003
    Inventors: Landon Duval, Ronald Louis Williams
  • Patent number: 6488623
    Abstract: The disclosure relates to a device for determining perfusion capacity in a region of a patient's skin and underlying tissue utilizing a thermoelectric device to create a temperature differential, a sensor for measuring the temperature differential, a controller coupled to the sensor and the thermoelectric device for maintaining the temperature differential substantially constant by providing electrical energy to the thermoelectric device, and measuring the electrical energy provided to the thermoelectric device when the thermoelectric device is positioned adjacent the region of the patient's skin to indicate perfusion capacity.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: December 3, 2002
    Assignee: Hill-Rom Services, Inc.
    Inventors: Ryszard S. Ozarowski, William T. Sutton
  • Publication number: 20020007115
    Abstract: Differentiating breast ducts for cancer risk status is a key element in a procedure to screen women for breast cancer. The 6 to 9 breast ducts on the human breast can be differentiated to identify those of higher risk for cancer. The higher risk ducts merit access and analysis of the ductal fluid and monitoring and/or treatment.
    Type: Application
    Filed: May 10, 2001
    Publication date: January 17, 2002
    Inventors: David Hung, Susan Love
  • Patent number: 6248066
    Abstract: An apparatus for evaluating perfusion adjacent a skin surface includes a housing having first an second interior regions. The housing is configured to engage the skin surface. The apparatus also includes a plunger located in the first region of the housing for applying pressure to a first zone of the skin surface, a vacuum connection coupled to the second region of the housing to permit suction to be applied to the second region of the housing and to a second zone of the skin surface, a first temperature sensor for generating an output signal related to the temperature of the first zone of the skin surface, a second temperature sensor for generating an output signal related to the temperature of the second zone of the skin surface, and a processor circuit coupled to the first and second temperature sensors for determining a differential temperature between the first and second zones of the skin surface to provide an indication of perfusion adjacent the skin surface.
    Type: Grant
    Filed: January 3, 2000
    Date of Patent: June 19, 2001
    Assignee: Hill-Rom, Inc.
    Inventors: Richard I. Barnett, Ryszard S. Ozarowski, William T. Sutton, James M. C. Thomas, William C. Knapp
  • Patent number: 6183418
    Abstract: The process for detection and for quantitative determination of substances emitted or perspired through the skin is derived from flow diffusion analysis. The measuring system conceived for this purpose uses a diffusion half cell through which an acceptor medium flows and which is closed by a membrane. For the duration of the measurement, the membrane is brought into contact with the skin or a closed gas volume formed over the skin. With the process and the related measuring system, the blood alcohol level can be determined with a good degree of precision indirectly via the quantity of (gaseous) ethanol emitted through the skin.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: February 6, 2001
    Assignees: Trace Analysensysteme GmbH, Moller Feinmechanik GmbH & Co., META Mebtechnische Systeme GmbH
    Inventor: Wolfgang Kuennecke
  • Patent number: 6013029
    Abstract: The concentration of a substance or group of substances in a body fluid is monitored by means of an interface held in contact with a living human or animal body and a detector is positioned downstream from the interface. A profusion fluid is passed from the interface to and along the detector at a flow rate of less than 60 .mu.l/hour. A constant flow is maintained at the low flow rate with very little or no supply of energy, allowing for a compact construction and reduced measurement delay.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: January 11, 2000
    Inventors: Jakob Korf, Thomas Henricus Marie Terwee
  • Patent number: 6010455
    Abstract: An apparatus for evaluating perfusion adjacent a skin surface includes a housing having first and second interior regions. The housing is configured to engage the skin surface. The apparatus also includes a plunger located in the first region of the housing for applying pressure to a first zone of the skin surface, a vacuum connection coupled to the second region of the housing to permit suction to be applied to the second region of the housing and to a second zone of the skin surface, a first temperature sensor for generating an output signal related to the temperature of the first zone of the skin surface, a second temperature sensor for generating an output signal related to the temperature of the second zone of the skin surface, and a processor circuit coupled to the first and second temperature sensors for determining a differential temperature between the first and second zones of the skin surface to provide an indication of perfusion adjacent the skin surface.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: January 4, 2000
    Assignee: Hill-Rom, Inc.
    Inventors: Richard I. Barnett, Ryszard S. Ozarowski, William T. Sutton, James M. C. Thomas, William C. Knapp
  • Patent number: 5769784
    Abstract: An apparatus and method for evaluating perfusion adjacent a skin surface includes the steps of measuring a reference rate of perfusion of the skin surface, storing the reference rate of perfusion, and applying a positive force to the skin surface. The apparatus and method also includes the steps of measuring a second rate of perfusion adjacent the skin surface after the positive force is applied, and calculating a differential rate of perfusion between the reference rate of perfusion and the second rate of perfusion after positive force is applied to provide an indication of perfusion adjacent the skin surface. The apparatus and method further includes the step of displaying the indication of perfusion.
    Type: Grant
    Filed: November 27, 1995
    Date of Patent: June 23, 1998
    Assignee: Hill-Rom, Inc.
    Inventors: Richard I. Barnett, Ryszard S. Ozarowski, William T. Sutton, James M. C. Thomas