Electrode In Brain Patents (Class 600/378)
  • Patent number: 10363417
    Abstract: A cochlear implant system is described which includes an implant housing containing a stimulation processor for processing externally produced communications signals to generate electrical stimulation signals for the cochlea of an implant patient. The implant housing lies substantially in a plane and has an outer perimeter adapted to fit within a surgically prepared housing recess in skull bone of the implant patient. Multiple housing fixation features are located on the outer perimeter and cooperate to develop lateral force in the plane of the implant housing between the implant housing and adjacent skull bone of the housing recess to fixedly secure the implant housing within the housing recess.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: July 30, 2019
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventor: Stefan B. Nielsen
  • Patent number: 10349860
    Abstract: Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveforms over large brain surface areas by any of the devices disclosed herein.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: July 16, 2019
    Assignees: The Board of Trustees of the University of Illinois, The Trustees of the University of Pennsylvania
    Inventors: John A. Rogers, Dae-Hyeong Kim, Brian Litt, Jonathan Viventi
  • Patent number: 10342985
    Abstract: The present invention relates to a treatment apparatus using high frequency waves, and to a method for controlling same. The treatment apparatus using high frequency waves comprises: a high frequency wave generating unit; a plurality of needles for providing, into the skin of a user, high frequency energy transferred from the high frequency wave generating unit; and a driving unit for inserting the plurality of needles into the skin of the user, wherein the apparatus further comprises a control unit for controlling the driving unit such that the plurality of needles are inserted into a first target point within the skin and then move to a second target point.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: July 9, 2019
    Assignee: Lutronic Corporation
    Inventor: Kwang Chon Ko
  • Patent number: 10220200
    Abstract: A device for cranial implantation includes a ferrule and a plate for placement in the ferrule. Furthermore, a neurological implant system includes a probe and a device for cranial implantation.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: March 5, 2019
    Assignee: Medtronic Bakken Research Center B.V.
    Inventors: Michel Marcel Jose Decre, Johannes Cornelius Antonius Muller, Michel Gerardus Pardoel, Hubert Cecile Francois Martens
  • Patent number: 10123718
    Abstract: The present disclosure discuses systems and methods for detecting and recording bioelectric signals, and specifically bioelectrical signals generated by abdominal organs, such as the uterus. The disclosure discusses area electrodes and arrays of area electrodes. The area electrodes are defined in a metal layer and include an inner and outer diameter. The area electrodes are configured to detect electrical signals generated substantially perpendicular to a surface of the area electrode while rejecting electrical signals generated substantially parallel to the surface of the area electrode.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: November 13, 2018
    Assignee: University of Tenessee Research Foundation
    Inventor: Roger Charles Young
  • Patent number: 10086192
    Abstract: Devices and methods for manipulating devices such as micro-scale devices are provided. The devices can include a tether of various materials surrounded by a stiff body. The tether interfaces with microscale devices to draw them against the stiff body, holding the microscale devices in a locked position for insertion into or extraction out of tissue. The tensional hook and stiff body are configurable in a multitude of positions and geometries to provide increased engagement. Such configurations allow for a range of implantation and extraction surgical procedures for the device within research and clinical settings.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: October 2, 2018
    Assignee: Modular Bionics Inc.
    Inventors: Ian Loren Halpern, Mark William Merlo
  • Patent number: 10035024
    Abstract: The present invention relates to a treatment apparatus using high frequency waves, and to a method for controlling same. The treatment apparatus using high frequency waves comprises: a high frequency wave generating unit; a plurality of needles for providing, into the skin of a user, high frequency energy transferred from the high frequency wave generating unit; and a driving unit for inserting the plurality of needles into the skin of the user, wherein the apparatus further comprises a control unit for controlling the driving unit such that the plurality of needles are inserted into a first target point within the skin and then move to a second target point.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: July 31, 2018
    Assignee: Lutronic Corporation
    Inventor: Kwang Chon Ko
  • Patent number: 9999363
    Abstract: A modular, high density electrical system is disclosed which makes use of an interface component, which is well suited to being placed in contact with an anatomy of either a human or an animal, and which may be releasably coupled to an electronics module subsystem. The interface component has a plurality of electrically conductive interconnect pads that may be releasably secured by a member to a plurality of electrically conductive pads of the electronics module subsystem. The electronics module subsystem may have a substrate which supports both an electronics circuit and the interconnect pads.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: June 19, 2018
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Kedar G. Shah, Sarah H. Felix, Satinderpall S. Pannu, Vanessa Tolosa, Angela C. Tooker
  • Patent number: 9986914
    Abstract: An optrode may provide a cylindrical substrate two or more electrodes deposited said cylindrical substrate. The cylindrical substrate and electrodes may be coated by an insulating layer with openings or vias over certain portions of the electrodes that may provide a contact for the neural probe or may be utilized to connect lead lines. Manufacturing of an optrode may utilize a jig that secures a cylindrical substrate coated by a conductive material and a resist. A first mask may be positioned in an opening provided by the jig, and the cylindrical substrate may be exposed ions or neutral particles to define one or more electrode patterns. After regions of the resist and conductive material are removed to form the electrodes, a second mask may be utilized to define vias regions in which portions of the electrodes are exposed and uncoated by an insulating layer.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: June 5, 2018
    Assignees: UNIVERSITY OF HOUSTON SYSTEM, VANDERBILT UNIVERSITY
    Inventors: John C. Wolfe, Mufaddal Gheewala, Wei-Chuan Shih, Gopathy Purushothaman
  • Patent number: 9956034
    Abstract: A system for controlled sympathectomy procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. Systems and methods for accessing target tissues as part of a neuromodulation procedure from within a lumen are disclosed.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: May 1, 2018
    Assignee: AUTONOMIX MEDICAL, INC.
    Inventors: Landy Toth, Roy Martin
  • Patent number: 9895101
    Abstract: A method for identifying changes in an epilepsy patient's disease state, comprising: receiving at least one body data stream; determining at least one body index from the at least one body data stream; detecting a plurality of seizure events from the at least one body index; determining at least one seizure metric value for each seizure event; performing a first classification analysis of the plurality of seizure events from the at least one seizure metric value; detecting at least one additional seizure event from the at least one determined index; determining at least one seizure metric value for each additional seizure event, performing a second classification analysis of the plurality of seizure events and the at least one additional seizure event based upon the at least one seizure metric value; comparing the results of the first classification analysis and the second classification analysis; and performing a further action.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: February 20, 2018
    Assignee: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 9861288
    Abstract: Devices for detecting electrical activity in electrically active biological tissues and methods for using the devices are provided. The devices include an electrode array that is configured for implantation on electrically active biological tissue. The electrode array comprises a plurality of electrode sites comprising one or more layers of transparent, electrically conductive graphene disposed on a transparent substrate.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: January 9, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Zhenqiang Ma, Justin Cole Williams, Dong-Wook Park, Amelia Ann Schendel, Solomon Tadesse Mikael
  • Patent number: 9782200
    Abstract: A neuromonitoring needle electrode placement gun which includes a housing, at least a first needle electrode and housing assembly, an elongated channel dimensioned and configured for accommodating axial movement of the at least a first needle electrode and housing assembly within the channel and for directing movement of the at least a first needle electrode and housing assembly and a pusher dimensioned and configured for engaging the at least a first needle electrode and housing assembly and for axially displacing the at least a first needle electrode and housing assembly.
    Type: Grant
    Filed: February 9, 2014
    Date of Patent: October 10, 2017
    Inventor: John E Burbank
  • Patent number: 9744371
    Abstract: The present invention relates to a treatment apparatus using high frequency waves, and to a method for controlling same. The treatment apparatus using high frequency waves comprises: a high frequency wave generating unit; a plurality of needles for providing, into the skin of a user, high frequency energy transferred from the high frequency wave generating unit; and a driving unit for inserting the plurality of needles into the skin of the user, wherein the apparatus further comprises a control unit for controlling the driving unit such that the plurality of needles are inserted into a first target point within the skin and then move to a second target point.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: August 29, 2017
    Assignee: Lutronic Corporation
    Inventor: Kwang Chon Ko
  • Patent number: 9731114
    Abstract: An intraoperative multichannel brain probe is presented. The brain probe has a cylindrical upper stainless steel section attached to a lower cylindrical section. In the lower section, an outer cylindrical tube surrounds a second insulating tube. Electrically recording/stimulating wires are placed between the outer tube and the second tube. Each wire has one end protruding out a hole in the outer tube. The other end of each wire is threaded through the entire probe and electrically connected to a recording or stimulating device through a connector system. A number of insulating tubes and electrodes located inside the second tube may also be part of the brain probe. Each inner electrode, typically two, is insulated from each other and from the second insulating tube by other insulating tubes. The combination of one or more wires and electrodes provides a multi-functional device.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: August 15, 2017
    Inventors: Martin J. Bak, Brian H. Bak
  • Patent number: 9694190
    Abstract: An implantable device has a cylindrical base, at least one electrode on the cylindrical base, at least one electrically conducting lead on the cylindrical base connected to the electrode wherein the electrically conducting lead has a feature size of <10 micrometers. A protective coating on the cylindrical base covers the at least one electrically conducting lead.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 4, 2017
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Vanessa Tolosa, Satinderpall S. Pannu, Heeral Sheth, Angela C. Tooker, Kedar G. Shah, Sarah H. Felix
  • Patent number: 9662026
    Abstract: The present invention provides a three-dimensional electrode having high cell affinity and capacitive coupling, comprising a pillar portion and a spherical portion, wherein the diameter of the spherical portion is larger than that of the pillar portion, and the carbon nanotubes are coated on the spherical portion, and pillar portion and the spherical portion are made of material selected from metal materials. The present invention may be used for developing biological probes having high cell affinity and capacitive coupling so as to provide high accuracy for measurement of neural cells or electrocardiograms and prevent from distortion.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: May 30, 2017
    Assignee: National Tsing Hua University
    Inventors: I-An Pan, Tri-Rung Yew, Hsin Chen, Yung-Jen Chuang
  • Patent number: 9597493
    Abstract: Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: March 21, 2017
    Assignee: NeuroPace, Inc.
    Inventors: Brett Wingeier, Benjamin Pless
  • Patent number: 9414762
    Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: August 16, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, Jr.
  • Patent number: 9409032
    Abstract: A control module for providing electrical stimulation of patient tissue includes a header disposed over an electrical interface. A connector assembly retainer is disposed in the header and coupled to the electrical interface. The connector assembly retainer includes a plurality of channels and a plurality of apertures defined at one end of the connector assembly retainer. Each of a plurality of connector assemblies is disposed in a different one of the plurality of channels of the connector assembly retainer. Each of the plurality of connector assemblies is configured and arranged for receiving a portion of a lead or lead extension and coupling the lead or lead extension to the electronic subassembly.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: August 9, 2016
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Randall L. Brase, Roger Evan Furgang, Robert R. Tong
  • Patent number: 9408530
    Abstract: Methods of controlling the operation of a device traveling in a body tube tree, including sensing parameters from possible directions of travel and selecting the direction of travel based on the sensed parameters, implemented with a control system located partially or fully on the lumen traveling device. Various actions can be performed by the device for, e.g., medical or therapeutic purposes. Machine-readable media including instructions for performing the methods are also described.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: August 9, 2016
    Assignee: Gearbox, LLC
    Inventors: Bran Ferren, W. Daniel Hillis, Roderick A. Hyde, Muriel Y. Ishikawa, Edward K. Y. Jung, Eric C. Leuthardt, Nathan P. Myhrvold, Thomas J. Nugent, Jr., Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 9409036
    Abstract: A connecting system includes an implantable base unit having an implantable housing with an externally accessible magnetic portion and an implantable unit connecting member. The implantable base unit is configured to be at least partially implanted in a subject such that the externally accessible magnetic portion is accessible from an external region of the subject. An interface unit is releasably coupled to the implantable base unit. The interface unit has an interface housing with an interface magnetic portion and an interface unit connecting member. The interface magnetic portion is configured to engage the externally accessible magnetic portion of the implantable base unit to mechanically couple the implantable unit connecting member and the interface unit connecting member.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: August 9, 2016
    Assignee: Wake Forest University Health Sciences
    Inventor: David Klorg
  • Patent number: 9387320
    Abstract: Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: July 12, 2016
    Assignee: NeuroPace, Inc.
    Inventors: Brett Wingeier, Benjamin Pless
  • Patent number: 9354267
    Abstract: Preferably, an embodiment of a sensor probe assembly includes at least a conductive pin securement member, and a multitude of conductive pins cooperating with the conductive pin securement member. Each conductive pin has a multitude of degrees of freedom relative to, as well as separate and distinct from, each of the remaining plurality of conductive pins. More preferably, an embodiment of a sensor probe assembly includes at least a flexible, electrically conductive pin securement member formed from a polymer filled with conductive particles. Interacting with the flexible, electrically conductive pin securement member is a plurality of electrically conductive pins, wherein each electrically conductive pin has a multitude of degrees of freedom relative to each of the remaining plurality of conductive pins, and cooperates with the electrically conductive pin securement member in a pressing engagement relationship.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: May 31, 2016
    Assignee: Neurotopia, Inc.
    Inventor: Dale Dalke
  • Patent number: 9259567
    Abstract: A method of manufacturing an implantable electronic device, including: providing a silicon wafer; building a plurality of layers coupled to the wafer including an oxide layer coupled to the silicon wafer; a first reactive parylene layer coupled to the oxide layer, an electrode layer coupled to the first reactive parylene layer, and a second reactive parylene layer, coupled to the electrode layer, that chemically bonds to the first reactive polymer layer, and a second polymer layer coupled to the second reactive parylene layer; coating the plurality of layers with an encapsulation, and modifying the encapsulation and at least one of the plurality of layers to expose an electrode site in the electrode layer.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: February 16, 2016
    Assignee: The Regents Of The University Of Michigan
    Inventors: John Seymour, Mayurachat Ning Gulari, Joerg Lahann, Daryl Kipke
  • Patent number: 9247889
    Abstract: A neural probe is disclosed for optically stimulating or silencing neurons and recording electrical responses to the stimulus. Using patterning techniques, an integral optical waveguide may be fabricated on the probe for transmitting neuron-affecting light from a light source to a probe tip. The probe tip may include one or more electrodes to receive electrical responses from stimulated neurons for recording or further processing. According to various embodiments, the disclosed neural probes may utilize multiple light sources simultaneously, switch between multiple light sources, or utilize a single light source to stimulate or silence multiple neuron locations simultaneously via multiple probe tips or via multiple light-emitting sites located along the length of the probe. Neural probes are thereby provided that have sufficient spatial resolution to accurately target, stimulate, and record the reaction of neurons, or as few as a single neuron, utilizing a slim, compact structure.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: February 2, 2016
    Assignee: The Regents of The University of Michigan
    Inventors: Euisik Yoon, Il-Joo Cho
  • Patent number: 9233245
    Abstract: A method for treating a subject is provided, including applying electrical stimulation to a site of the subject selected from the group consisting of: a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve. The stimulation is configured to excite nervous tissue of the site at a strength sufficient to induce at least one neuroprotective occurrence selected from the group consisting of: an increase in cerebral blood flow (CBF) of the subject, and a release of one or more neuroprotective substances, and insufficient to induce a significant increase in permeability of a blood-brain barrier (BBB) of the subject.
    Type: Grant
    Filed: January 2, 2015
    Date of Patent: January 12, 2016
    Assignee: BRAINSGATE LTD.
    Inventors: Itschak Lamensdorf, Avinoam Dayan, Hernan Altman
  • Patent number: 9203175
    Abstract: An inline connector assembly having a bottom body structure and a top body structure hingedly connected thereto. The bottom body structure has a plurality of resilient conductive members to receive the conductive portions of the inline tail which is received in a longitudinal bore in the top body structure. A latch structure is provided to maintain the inline connector assembly in a closed position. An electrode tail guide and stop member are provided in the inline connector assembly for ease of electrode insertion and tail contact alignment.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: December 1, 2015
    Assignee: PMT Corporation
    Inventor: Benjamin J. Osa
  • Patent number: 9135400
    Abstract: This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, a target volume of activation (VOA) can be received, a test VOA can be simulated, and at least one of a target electrode location or parameter can be provide using a relationship between the target VOA and the test VOA.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: September 15, 2015
    Assignee: The Cleveland Clinic Foundation
    Inventors: Cameron C. McIntyre, Christopher R. Butson, John D. Hall, Jaimie M. Henderson
  • Patent number: 9061134
    Abstract: Disclosed herein are systems and methods for producing and using electrodes, which may be flexible and/or stretchable, and interconnection structures that can be used both externally and/or implanted within the body. Electrodes according to various embodiments disclosed herein may be produced by depositing patterned layers of insulating and conductive polymers to form multi-layer circuits. The conductive materials and layers in the structure can be exposed on the surface of the structures for use as electrodes. A plurality of electrodes may be formed into an electrode array. In various embodiments, electrode arrays may be associated with telemetry modules configured to wirelessly transmit data collected by the electrode array to a receiver module.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: June 23, 2015
    Assignee: Ripple LLC
    Inventors: Robert E. Askin, III, Scott D. Hiatt, Kenneth S. Guillory, Daniel McDonnall, Christopher F. Smith
  • Publication number: 20150133761
    Abstract: A three-dimensional neural probe electrode array system is described. Planar probes are microfabricated and electrically connected to flexible micro-machined ribbon cables using a rivet bonding technique. The distal end of each cable is connected to a probe with the proximal end of the cable being customized for connection to a printed circuit board. Final assembly consists of combining multiple such assemblies into a single structure. Each of the two-dimensional neural probe arrays is positioned into a micro-machined platform that provides mechanical support and alignment for each array. Lastly, a micro-machined cap is placed on top of each neural electrode probe and cable assembly to protect them from damage during shipping and subsequent use. The cap provides a relatively planar surface for attachment of a computer controlled inserter for precise insertion into the tissue.
    Type: Application
    Filed: November 10, 2014
    Publication date: May 14, 2015
    Inventors: Rio J. Vetter, Jamille Farraye Hetke, David S. Pellinen, Bencharong Suwarato, Kc Kong
  • Patent number: 9008780
    Abstract: Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. The present disclosure provides, among other things, a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: April 14, 2015
    Assignees: Case Western Reserve University, University of Kansas
    Inventors: Randolph J. Nudo, David Guggenmos, Pedram Mohseni, Meysam Azin
  • Patent number: 9008747
    Abstract: The neural interface system of one embodiment includes a cylindrical shaft, a lateral extension longitudinally coupled to at least a portion of the shaft and having a thickness less than a diameter of the shaft, and an electrode array arranged on the lateral extension and radially offset from the shaft, including electrode sites that electrically interface with their surroundings. The method of one embodiment for making the neural interface system includes forming a planar polymer substrate with at least one metallization layer, patterning on at least one metallization layer an electrode array on a first end of the substrate, patterning conductive traces on at least one metallization layer, rolling a portion of the substrate toward the first end of the substrate, and securing the rolled substrate into a shaft having the first end of the substrate laterally extending from the shaft and the electrode array radially offset from the shaft.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: April 14, 2015
    Assignee: NeuroNexus Technologies, Inc.
    Inventors: John Seymour, Jamille Hetke, Rio Vetter, Daryl Kipke, David Pellinen, Kc Kong
  • Publication number: 20150080695
    Abstract: Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveform over large brain surface areas by any of the devices disclosed herein.
    Type: Application
    Filed: November 4, 2014
    Publication date: March 19, 2015
    Inventors: John A. ROGERS, Dae-Hyeong KIM, Brian LITT, Jonathan VIVENTI
  • Patent number: 8977335
    Abstract: A cortical sensing device for contact with the surface of the brain is provided that includes a support member, at least one macroelectrode sensing element secured with respect to the support member and at least one microelectrode sensing element secured with respect to the macroelectrode. The support member is substantially thin and made from flexibly-conformable material to accurately and safely place the sensing device upon the brain surface. The microelectrode sensing element is surrounded by the macroelectrode brain-contact surface of the macroelectrode sensing element. The first surface of the support member, the macroelectrode brain-contact surface and the microelectrode brain-contact surface are substantially co-planar to abut the surface of the brain for sensing and monitoring.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: March 10, 2015
    Assignee: Ad-Tech Medical Instrument Corp.
    Inventor: David A. Putz
  • Publication number: 20150065831
    Abstract: Disclosed herein is a wireless implantable communication system, method and sensing device, wherein an implantable data conversion module is adapted for operative coupling to a distinct or integrated implantable sensing device for the conversion of a characteristic signal for transmission thereof to an external receiver, e.g. by way of an inductive element. Upon positioning an external inductive element in the vicinity of the implanted device, a corresponding signal is induced within the external element allowing for reconstruction of the converted signal, and thereby allowing for recovery of the characteristic signal. Embodiments for the communication of data across a biological barrier, including communications from an external transmitter to an implanted receiver, an implanted transmitter to an external receiver, and an implanted transmitter/receiver pair are also disclosed.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 5, 2015
    Inventors: Milos R. Popovic, Massimo Tarulli, Aleksandar Prodic, Santa Concepcion Huerta Olivares
  • Patent number: 8958862
    Abstract: An implantable device for body tissue, including an electrical subsystem that flexes within and interfaces with body tissue and a carrier that operates in the following two modes: provides structural support for the electrical subsystem during implantation of the device in body tissue and allows flexing of the electrical subsystem after implantation of the device in body tissue. The implantable device is preferably designed to be implanted into the brain, spinal cord, peripheral nerve, muscle, or any other suitable anatomical location. The implantable device, however, may be alternatively used in any suitable environment and for any suitable reason.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: February 17, 2015
    Assignee: NeuroNexus Technologies, Inc.
    Inventors: Jamille F. Hetke, Daryl R. Kipke, Rio J. Vetter
  • Publication number: 20150045642
    Abstract: Subdural arrays transmit electrocorticogram recordings wirelessly, across the patient's skull, allowing the craniotomy used for surgical placement of the arrays to be completely closed. In various embodiments, the arrays also respond to commands, applying signal patterns to the patient's brain for diagnostic and treatment purposes.
    Type: Application
    Filed: August 21, 2014
    Publication date: February 12, 2015
    Inventors: Stuart F. Cogan, Philip R Troyk, John S. Ebersole, Vernon L. Towle
  • Publication number: 20150038822
    Abstract: Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.
    Type: Application
    Filed: October 6, 2014
    Publication date: February 5, 2015
    Inventors: Brett WINGEIER, Benjamin PLESS
  • Patent number: 8939153
    Abstract: A transponder string comprising multiple transponders is configured for injection into human tissue. In one embodiment, the transponders are sized to move through a needle for injection into the human tissue. Positions of the transponders with reference to one another may be maintained by coupling the transponders via a filament, adhesive backed substrate, shrink tubing, and/or any other suitable substrate. The transponders are configured to transmit data to a mobile computing device, e.g., a wand, smart phone or wireless tablet positioned outside the human tissue such that positions of the transponders are determinable, e.g., during an excision surgery.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 27, 2015
    Assignee: Health Beacons, Inc.
    Inventors: Murray A. Reicher, Robert Petcavich
  • Publication number: 20150018659
    Abstract: The invention described herein consists of a process that enables increased adhesion of thin film materials (such as metals, metal oxides, carbon nanotubes or other materials) to solvent and temperature sensitive, and non-planar, polymer substrates and the fabrication of softening electronics. Importantly, this process can be used to create exceptional embodiments of the disclosed flexible electronic devices having dynamic properties that make them suitable for implantation in the human body.
    Type: Application
    Filed: February 3, 2013
    Publication date: January 15, 2015
    Inventors: Taylor Ware, Walter Voit
  • Patent number: 8934965
    Abstract: Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveform over large brain surface areas by any of the devices disclosed herein.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: January 13, 2015
    Assignees: The Board of Trustees of the University of Illinois, The Trustees of the University of Pennsylvania
    Inventors: John Rogers, Dae-Hyeong Kim, Brian Litt, Jonathan Viventi
  • Publication number: 20140378807
    Abstract: Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.
    Type: Application
    Filed: September 12, 2014
    Publication date: December 25, 2014
    Inventors: Benjamin D. PLESS, Stephen T. ARCHER, Craig M. BAYSINGER, Barbara GIBB, Suresh GURUNATHAN, Thomas K. TCHENG
  • Publication number: 20140356892
    Abstract: In an aspect of the disclosure, a stimulation device includes a probe attached to a first support. The probe includes at least one grating coupler for coupling light into the probe. The device further includes at least one optical source for providing an optical stimulation signal mounted on a second support, and at least one means for detachably attaching the first support to the second support. The position of the at least one optical source is aligned with the position of the at least one grating coupler to allow light emitted from the at least one optical source to be received by the at least one grating coupler.
    Type: Application
    Filed: May 29, 2014
    Publication date: December 4, 2014
    Applicants: IMEC, KATHOLIEKE UNIVERSITEIT LEUVEN, KU LEUVEN R&D
    Inventors: Luis Diego Leon Hoffman, Dries Braeken, Silke Musa
  • Patent number: 8886278
    Abstract: An optical stimulation probe has a probe body inserted into a subject, an electrode formed on the probe body and collecting a response signal from the subject, a light irradiator attached to the probe body and irradiating an optical signal and a reflecting surface formed on the probe body on the path of the optical signal. The reflecting surface changes the course of the optical signal irradiated from the light irradiator to the direction where the electrode faces by reflecting the optical signal. The electrode may be formed on a side portion of the probe body such that it faces a direction perpendicular to a length direction of the probe body, and the optical signal reflected by the reflecting surface may travel along a direction perpendicular to the length direction of the probe body, such that the direction where the electrode faces and the direction along which the reflected optical signal travels are parallel to each other.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: November 11, 2014
    Assignee: Korea Institute of Science and Technology
    Inventors: JinSeok Kim, Eui-Sung Yoon, Hyun-Joon Shin, Jun-Kyo Francis Suh
  • Patent number: 8886279
    Abstract: A method of fabricating an array of micro electrodes enabled to have customizable lengths. A substantially criss-cross pattern of channels on a top surface of the work-piece substrate (10) is formed using electrical discharge machining to form a plurality of shaped columns (20) having tapered profiles. The shaped columns have a tapering profile which extends at least 50% of the length of the columns. The plurality of shaped columns is etched to sharpen the tapered tips into needle tips forming the array of microelectrodes.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: November 11, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Prashant Tathireddy, Florian Solzbacher
  • Patent number: 8883716
    Abstract: Devices and methods for treating diseases associated with loss of neuronal function are described. The methods are designed to promote proliferation, differentiation, migration, or integration of endogenous progenitor stem cells of the central nervous system (CNS). A therapy, such as an electrical signal or a stem cell enhancing agent, or a combination of therapies, is applied to a CNS region containing endogenous stem cells or a CNS region where the endogenous stem cells are predicted to migrate and eventually reside, or a combination thereof.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: November 11, 2014
    Assignee: Medtronic, Inc.
    Inventor: Lisa L. Shafer
  • Patent number: 8855737
    Abstract: A system and method for electrically shielding a physiological pathway from electrical noise is disclosed. The method includes the operation of implanting at least one signal microelectrode into a patient such that the signal microelectrode is proximate to the physiological pathway. An additional operation includes substantially enclosing the microelectrode and a section of the physiological pathway with an electrical shielding wrap. The electrical shielding wrap includes a plurality of holes that enable fluid communication of physiological fluids between an inside and outside of the wrap.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: October 7, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Gregory Arthur Clark, David James Warren, Noah M. Ledbetter
  • Publication number: 20140296680
    Abstract: Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
    Type: Application
    Filed: June 13, 2014
    Publication date: October 2, 2014
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Charles J. Bruce, David R. Holmes, JR.
  • Patent number: 8849369
    Abstract: Subdural arrays transmit electrocorticogram recordings wirelessly, across the patient's skull, allowing the craniotomy used for surgical placement of the arrays to be completely closed. In various embodiments, the arrays also respond to commands, applying signal patterns to the patient's brain for diagnostic and treatment purposes.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: September 30, 2014
    Assignee: EIC Laboratories
    Inventors: Stuart F. Cogan, Philip R. Troyk, John S. Ebersole, Vernon L. Towle