Measuring Impedance To Flow Of Aqueous Humor (tonometry) Patents (Class 600/399)
  • Patent number: 11087444
    Abstract: The present disclosure relates to imaging systems and methods relating to the processing of images. An example imaging system includes at least one camera, a display, and a processor, including a field programmable gate array (FPGA). The FPGA is configured to carry out operations. The operations include receiving at least one image among a series of image frames. The operations additionally include adjusting the at least one image to provide at least one adjusted image. Adjusting the at least one image includes partitioning the at least one image into a plurality of tile images, performing a contrast-limited histogram equalization on each tile image, and performing a bilinear interpolation for nearest neighbor tile of each tile image. The operations also include outputting the at least one adjusted image to the display.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: August 10, 2021
    Assignee: The Boeing Company
    Inventor: Simon X. Griego
  • Patent number: 10966738
    Abstract: Devices, systems and methods for ocular ultrasound are provided having therapeutic and/or diagnostic applications. In one aspect, an ocular probe is disclosed that is uniquely configured for use in the eye on the basis of shape and frequency. The ocular probe may be multi-functional, providing sensor, optical or other functionality in additional to ultrasound energy.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: April 6, 2021
    Assignee: DOHENY EYE INSTITUTE
    Inventor: Mark S. Humayun
  • Patent number: 10070821
    Abstract: An intraocular pressure measuring and/or monitoring system comprises an intraocular pressure measuring device (1) comprising a support (3) and a pressure sensor (2) united with the support. The support (3) is configured for placing the pressure sensor (2) in contact with an eye (8) of a user for sensing the intraocular pressure (IOP) of the eye. A portable recording device (6) is configured for communicating with the intraocular pressure measuring device (1) and for storing data received from the intraocular pressure measuring device. The system further comprises an inertial and/or environmental sensor (9).
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: September 11, 2018
    Assignee: Sensimed SA
    Inventors: Matteo Leonardi, Jean-Marc Wismer
  • Patent number: 10052195
    Abstract: An implantable ophthalmic device with flexible, fluid-filled membranes provide dynamically variable optical power to restore lost accommodation in individuals suffering from presbyopia or aphakia without moving parts or reducing the amount of transmitted light. Actuating the device causes the fluid-filled membrane to change curvature, which produces a corresponding change in optical power. For instance, squeezing the edge of the membrane causes the center of the membrane to bulge by an amount proportional to the squeezing force. Alternatively, heating or applying a voltage to the membrane may cause the liquid in the membrane to undergo a phase transition accompanied by a corresponding change in volume that causes the membrane to inflate so as to change the optical power of the device.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: August 21, 2018
    Assignee: ELENZA, INC.
    Inventors: Ronald David Blum, Rudy Mazzocchi
  • Patent number: 9723984
    Abstract: A contact lens shaped measuring device comprises a sensor having a protrusion towards the cornea. The measuring device is flexible to a degree that it is flattened by a closing eye lid and the protrusion creates an indentation of the cornea. The force on the protrusion is measured by the sensor. Applying a constant lid acceleration/deceleration model to the movement of the lid and a mechanical model to the cornea, the tension of the cornea is determined and deduced from the force measured with the lid closed, yielding the true intraocular pressure. In an alternative, the protrusion is characterized by a discontinuity in its shape, or the sensor is subdivided, each subsensor being characterized by a protrusion of different shape. With the values obtained as extrema and at the discontinuity or with different protrusions, the tension of the cornea can be obtained by a (linear) extrapolation.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: August 8, 2017
    Assignee: TISSOT MEDICAL RESEARCH SA
    Inventors: Alain Saurer, Jean-Noël Fehr
  • Patent number: 9517010
    Abstract: An ophthalmic instrument for viewing an eye under examination, wherein the instrument includes image capture means (26) for capturing an image of said eye and data processing means (40, 42, 46) for converting said image into a computer readable file, wherein the instrument carries a memory (44, 200), which may be detachable, for storing said file for subsequent transfer to a computer.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: December 13, 2016
    Assignee: Keelner Limited
    Inventor: Adrian Carl Beasley
  • Patent number: 9241623
    Abstract: An ocular axial length measurement apparatus is provided with: a measurement section for obtaining the ocular axial length of an examinee's eye by using an optical interferometer; a drive mechanism for adjusting the relative positions of the measurement section and the examinee's eye; an operation section operated by an examiner; and a control unit. The ocular axial length measurement apparatus is equipped with an ultrasonic probe for obtaining length information in an axial direction of the examinee's eye in advance, or configured to mount the ultrasonic probe. The control unit, when measuring the eye using the ultrasonic probe, changes a setting at the time of measuring the eye using the ultrasonic probe based on an operation signal output from the operation section.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: January 26, 2016
    Assignee: NIDEK CO., LTD.
    Inventor: Miyuki Satake
  • Publication number: 20150133743
    Abstract: A patient data capture and processing system comprises: a programmable, platform medical device comprising at least one patient sensor interface; a processor coupled to said sensor interface and to a communications interface; programmable memory, coupled to said processor. The memory is programmable via the communications interface to define a plurality of different patient sensing functions to implement, in software, a plurality of different medical devices. A patient medical device controller comprises a further communications interface coupled to the communications connection; a processor; memory, coupled to said processor, storing signal processing code to retrieve the medical device data from one or more of the programmable platform medical devices via the communications connection, to filter clinically significant events from said retrieved medical device data to detect clinically significant events, and to output the filtered data for one or both of storage and review by a physician.
    Type: Application
    Filed: March 20, 2013
    Publication date: May 14, 2015
    Inventor: Ehud Baron
  • Patent number: 8998810
    Abstract: The arrangement in a tonometer has a probe that is brought into contact with the surface of the eye and the intraocular pressure in the eye is derived from the variations in the velocity of the probe. The probe is formed of a piece of a non-magnetic substance. The arrangement includes a holder located in the tubular component and attached to a shaft providing the force for the measurement, in which holder there is a guiding means for guiding a movement of the probe along an internal surface of the tubular component.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: April 7, 2015
    Assignee: Tiolat Oy
    Inventor: Antti Kontiola
  • Publication number: 20150045633
    Abstract: A system and method for hemodynamic dysfunction detection may include at least one sensor configured to received one or more signals from a patient, a computing device in data communication with the at least one sensor, a computer-readable storage medium in communication with the computing device, an input device, and an output device. The system may include computer readable instructions to cause the system to receive at least one signal in the time domain from the sensor, determine at least one metric in the frequency domain from the at least one signal in the time domain, and determine the cardiovascular state of the patient from a combination of the at least one metric in the frequency domain and information contained in at least one database of cardiovascular states. The system may also notify a user of a immanent patient cardiovascular event and recommend one or more interventions to mitigate it.
    Type: Application
    Filed: August 12, 2014
    Publication date: February 12, 2015
    Inventors: Jan K. BERKOW, Anne M. BRUMFIELD
  • Patent number: 8951221
    Abstract: The invention relates to a method and device for the treatment of glaucoma, though insertion of an implant into the lumen of the Schlemm's canal to realize proper drainage of the aqueous humor, which implant is brought into its position in the Schlemm's canal by means of a catheter having a distal and a proximate portion and provided with a number of pores through which a gaseous or fluid medium which comes from a pressure source can emerge during insertion of the catheter carrying the implant into the Schlemm's canal, and while the catheter is being inserted into the Schlemm's canal the gaseous or fluid medium is released under pressure thereby expanding the Schlemm's canal and the implant and upon releasing the implant at its determined location, the catheter can be withdrawn from the Schlemm's canal.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: February 10, 2015
    Assignee: Grieshaber Ophthalmic Research Foundation
    Inventors: Robert Christopher Stegmann, Matthias Christian Grieshaber, Hans Rudolf Grieshaber
  • Patent number: 8926510
    Abstract: Described herein is a device for glaucoma treatment and monitoring that comprises a combination of an intraocular pressure (IOP) sensor and a glaucoma drainage device. The device comprises an IOP sensor and an inductive antenna mounted within a porous biocompatible material that forms the drainage path. The IOP sensor is mounted in a footplate portion of the device and is mountable in the anterior chamber of an eye. The footplate portion is connected to a body portion that houses the spiral antenna by a neck portion which retains the footplate portion in a suitable position within the anterior chamber. Due to its size, the footplate portion housing the IOP sensor can readily be inserted into the anterior chamber with the body portion housing the spiral antenna located outside of the anterior chamber in a sub-scleral space to disperse the aqueous humour.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: January 6, 2015
    Assignee: Istar Medical SA
    Inventors: Andrew J. Marshall, Max G. Maginness, Michel Alvarez
  • Patent number: 8926524
    Abstract: An implantable polymer-based pressure sensor featuring an electrical LC-tank resonant circuit for passive wireless sensing without power consumption on the implanted site. The sensor is microfabricated with parylene to create a flexible coil substrate that can be folded for smaller physical form factor during implantation, and can be stretched back without damage for enhanced inductive sensor-reader coil coupling. Data received from the sensor can be enhanced to provide improved pressure measurements at increased distances.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: January 6, 2015
    Assignee: California Institute of Technology
    Inventors: Po-jui Chen, Yu-Chong Tai
  • Patent number: 8920335
    Abstract: Systems and methods for determining a volume of the posterior segment of an eye during a fluid-to-gas exchange are described. The determined volume of the posterior segment may be used to determine the volume of pure tamponade gas to be introduced into the posterior segment resulting in a desired tamponade gas to other gas (e.g., air) ratio, such as during an ophthalmic surgical procedure. Particularly, the systems and methods may provide for improved gas utilization, less waste, and reduced surgery time, for example, by accurately measuring the volume of the posterior segment of the eye and only using the amount of pure gas required to produce the desired ratio. Further, in some implementations, mixing of a tamponade gas is accomplished intrinsically within the posterior segment of the eye, thereby avoiding manual mixing and reducing surgery time.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: December 30, 2014
    Assignee: Alcon Research, Ltd.
    Inventor: John Christopher Huculak
  • Patent number: 8894578
    Abstract: An implantable device for measuring IOP comprises a distal portion, a proximal portion and a conformable elongate support extending between the distal and proximal portions. The distal portion comprises a pressure sensor, for example a capacitor, and the proximal portion comprises a coil. The conformable elongate support extends between the distal portion and the coil so as to couple the distal portion to the coil, and the conformable elongate support is sized to position the sensor in the anterior chamber when the proximal portion is positioned under a conjunctiva of the eye. Positioning of the pressure sensor in the anterior chamber has the benefit of readily accessible surgical access and a direct measurement of the IOP of the eye. The proximal portion comprising the coil can be configured to place the coil between the sclera and the conjunctiva, such that the invasiveness of the surgery can be decreased substantially.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: November 25, 2014
    Assignee: Orthomems, Inc.
    Inventors: Vernon G. Wong, Douglas A. Lee
  • Publication number: 20140296688
    Abstract: A surface deformation sensor that includes a resonance circuit is described herein. The resonance circuit includes a sensing capacitor and inductive coil. The resonance circuit receives an external signal, which causes the resonance circuit to resonate at a resonance frequency. A surface deformation of an object can be determined based on the resonance frequency.
    Type: Application
    Filed: May 15, 2012
    Publication date: October 2, 2014
    Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: David Chuen Chun Lam, Guozhen Chen, Ion Seng Chan
  • Publication number: 20140275937
    Abstract: Apparatus and methods for calculating cardiac output (CO) of a living subject using applanation tonometry measurements. In one embodiment, the apparatus and methods build a nonlinear mathematical model to correlate physiologic source data vectors to target CO values. The source data vectors include one or more measurable or derivable parameters such as: systolic and diastolic pressure, pulse pressure, beat-to-beat interval, mean arterial pressure, maximal slope of the pressure rise during systole, the area under systolic part of the pulse pressure wave, gender (male or female), age, height and weight. The target CO values are acquired using various methods, across a plurality of individuals. Multidimensional nonlinear optimization is then used to find a mathematical model which transforms the source data to the target CO data. The model is then applied to an individual by acquiring physiologic data for the individual and applying the model to the collected data.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Inventors: Oliver Goedje, Matthias Bohn, Patrick Hunziker, Oleksii Morozov, Felix Friedrich
  • Patent number: 8834368
    Abstract: Apparatus and methods for subjecting a patient to an slit lamp microscopy and/or Goldmann tonometry eye examination are disclosed herein. In some embodiments, the patient is in a side-lying down position at a time of the examination. In some embodiments, it is possible to examine an upper and/or lower eye—for example, a lower eye slightly above a supporting surface. Related apparatus are disclosed herein. In some embodiments, the apparatus includes a bed and/or a headrest and/or a face immobilization assembly are disclosed herein.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: September 16, 2014
    Inventors: Yosef Glovinsky, Vadim Shmukler, Ilia Piven
  • Publication number: 20140257075
    Abstract: Technologies are provided to estimate in vivo aqueous humor outflow for a subject. The method can include: preparing a virtual casting of the outflow network of the subject by use of background subtraction and contrast enhancement; tracing network terminal branches in said reduced virtual casting; obtaining Doppler data for at least some of the terminal branches, to calculate a fluid velocity within each of such terminal branch; then pairing each fluid velocity for each such terminal branch with a measurement of cross-sectional area for that terminal branch, thereby to provide a plurality of volumetric flow values; and integrating over the plurality to obtain a volumetric estimate of aqueous humor outflow for the subject.
    Type: Application
    Filed: August 1, 2012
    Publication date: September 11, 2014
    Applicant: University of Pittsburgh - Of The Commonwealth System of Higher Education
    Inventors: Lawrence E. Kagemann, JR., Joel S. Schuman
  • Publication number: 20140163352
    Abstract: An applanation tonometer uses an active pixel sensor array to accurately detect total illumination in a region surrounding an applanated area so that a microprocessor can determine the applanated area based on an inversion of the illumination received by the sensor.
    Type: Application
    Filed: July 1, 2013
    Publication date: June 12, 2014
    Applicant: FALCK MEDICAL, INC.
    Inventors: Francis Y. Falck, JR., Robert W. Falck
  • Publication number: 20140155726
    Abstract: A dynamic tonometry device includes a probe, a housing, a sleeve, a light source, an image sensor, a pressure sensor, a microprocessor and a display storage. The probe is a truncated cone with small at left and large at right. The sleeve is fitted on the probe. An end face of a small end of the probe is situated to a left of a left end face of the sleeve. A right end of the sleeve is connected to a left end of the housing; on a large end of the probe is installed the pressure sensor; inside the housing are installed the light source and the image sensor. Light emitted by the light source is collimated into a light beam which is incident to the probe and totally reflected before entering the image sensor. With the microprocessor are connected the pressure sensor, the image sensor and the display storage.
    Type: Application
    Filed: January 7, 2013
    Publication date: June 5, 2014
    Applicant: HUAINAN NORMAL UNIVERSITY
    Inventors: Jianguo Ma, Jin Zhang, Yijie Wang, Ming Liu
  • Patent number: 8740795
    Abstract: An instrument has been designed to study the pulsatile motion of the eye by analysis of a beam of light reflected from the corneal surface. A laser light beam probe of small spot size and low divergence strikes the cornea apex and the reflected movement is recorded by a sensor. Analysis of the beam movement reveals the energy in the eye pulse without the necessity of physically touching the eye. The value of the intraocular pressure is determined from the calculated power spectrum. The sensitivity, accuracy and efficiency of the light beam makes possible studying both eyes concurrently and comparison of the pulse parameters of onset, amplitude and duration reveals any delay in circulation to an eye.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: June 3, 2014
    Inventors: John Lawrence Norris, Robert W Allison, Jr.
  • Patent number: 8721580
    Abstract: A glaucoma drainage device has an active valve configured to be located between an anterior chamber of an eye and a drainage location, a power source coupled to the active valve, and a controller coupled to the power source. A first pressure sensor is located in fluid communication with the anterior chamber, a second pressure sensor is located in the drainage location, and a third pressure sensor located remotely from the first and second pressure sensors. The controller reads the first, second, and third pressure sensors once during a period of time and adjusts the active valve to control intraocular pressure.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: May 13, 2014
    Assignee: Alcon Research, Ltd.
    Inventors: Matthew J. A. Rickard, Robert Joseph Sanchez, Jr.
  • Publication number: 20140073897
    Abstract: Ophthalmological device including an applanation tonometer tip having a bi-curved cornea-contacting surface and method of using such device for measurement of intraocular pressure. The cornea-contacting surface includes a first rotationally symmetric portion a curvature of which is substantially adapted to that of a typical cornea and a second rotationally symmetric portion that is peripheral to and adjoining the first portion. In operation, the applanation of the cornea in an area corresponding to the first portion of the cornea-contacting surface is substantially negligible.
    Type: Application
    Filed: August 28, 2013
    Publication date: March 13, 2014
    Inventor: Sean J. McCafferty
  • Patent number: 8617139
    Abstract: Disclosed are devices, methods and systems for treatment of eye disease such as glaucoma. Implants are described herein that enhance aqueous flow through the normal outflow system of the eye with minimal to no complications. The implant can be reversibly deformed to a first shape, such as a generally linear shape conducive to insertion. Upon insertion, the implant can deform to a second shape, such as a generally non-linear shape conducive to retention within the eye. The shape also improves fluid flow from the anterior chamber and prevents or reduces clogging.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: December 31, 2013
    Assignee: Transcend Medical, Inc.
    Inventors: Thomas A. Silvestrini, Steven John, Jose Garcia, Richard S. Lilly
  • Publication number: 20130184554
    Abstract: Disclosed is a device adapted to measure intraocular pressure comprising: a corneal contact lens having a pressure sensor mounted in a recess or cavity in the contact lens, and wherein the contact lens has a back surface which is formed so as to protrude in a desired portion beyond the profile of the adjacent part of the lens and thus to press against the cornea, which protruding portion experiences a reactive deformation which is detected directly or indirectly by the pressure sensor.
    Type: Application
    Filed: October 20, 2011
    Publication date: July 18, 2013
    Inventors: Ahmed Elsheikh, John Clamp
  • Publication number: 20130158381
    Abstract: An IOP monitoring device for implantation in an eye of a patient may include a first tube having a first opening, the first tube being configured to extend into an anterior chamber of the eye and extend to a first sensor outside the anterior chamber. The first sensor may be in fluid communication with the first opening of the first tube. The device also may include a second tube having an opening spaced from a second sensor. The opening of the second tube may be configured to be exposed to a pressure representative of atmospheric pressure, with the second sensor being in fluid communication with the second opening. In one aspect, a patch is attachable to a globe of the eye and configured to lie over the opening of the second tube and secure the opening in place in the eye.
    Type: Application
    Filed: February 29, 2012
    Publication date: June 20, 2013
    Inventor: Matthew J.A. Rickard
  • Patent number: 8444588
    Abstract: A surgical technique and device wherein an indwelling tube is placed in the eye of a patient having glaucoma. The tube diverts aqueous humor from the anterior chamber to the suprachoroidal space from which it is removed by blood flowing in the choroidal and uveal tissues. This decreases the intraocular pressure.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: May 21, 2013
    Assignee: Transcend Medical, Inc.
    Inventor: Michael Yablonski
  • Publication number: 20130085369
    Abstract: Apparatus and methods for subjecting a patient to an slit lamp microscopy and/or Goldmann tonometry eye examination are disclosed herein. In some embodiments, the patient is in a side-lying down position at a time of the examination. In some embodiments, it is possible to examine an upper and/or lower eye—for example, a lower eye slightly above a supporting surface. Related apparatus are disclosed herein. In some embodiments, the apparatus includes a bed and/or a headrest and/or a face immobilization assembly are disclosed herein.
    Type: Application
    Filed: August 27, 2012
    Publication date: April 4, 2013
    Inventors: Yosef Glovinsky, Vadim Shmukler, Ilia Piven
  • Patent number: 8323196
    Abstract: The invention relates to medicine. The inventive device for measuring intraocular tension through an eyelid comprises a body, a movable sleeve provided with a support and placed in the body in such a way that it is reciprocally displaceable for producing a static load applicable to the eyebulb through the eyelid, a rod which is provided with a flat base and is arranged in the sleeve cavity in such a way that it is displaceable with respect to the support and produces an impact action for deforming the eyebulb through the eyelid and at least one measuring coil placed in the movable sleeve.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: December 4, 2012
    Inventors: Gennadiy Konstantinovich Piletskiy, Konstantin Vasilyevich Ivanischev, Nikolai Gennadyevich Piletskiy, Alexandr Nikolaevich Chervyakov
  • Patent number: 8317701
    Abstract: A device and method are presented for use in non-invasive measurement of a patient's intra-ocular pressure (IOP). The device comprises a probe unit comprising a flexible membrane which is to be brought into contact with a patient's eyelid thereby enabling a contacting region of the membrane to match a shape of the eyelid defined by the shape of the patient's cornea. The device is configured to enable controllably varying application of force to the membrane against the eyelid and to enable illumination of the membrane at least within the contacting region thereof, the deformation of the illuminated membrane affecting detected light returned from the membrane, thereby enabling identification of a condition of applanation of a desired area of the membrane by identifying desired data indicative of the detected light and allowing the IOP measurement upon identifying said condition.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: November 27, 2012
    Assignee: A.T.I.- Advanced Medical Technologies Ltd.
    Inventors: Abraham Livne, Ilan Ron
  • Patent number: 8206333
    Abstract: The present invention relates to an ocular implant, particularly a glaucoma stent. It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis. In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: June 26, 2012
    Assignee: Universitaet Rostock
    Inventors: Wolfram Schmidt, Katrin Sternberg, Detlef Behrend, Rudolf Guthoff, Klaus-Peter Schmitz
  • Patent number: 8199491
    Abstract: A drainage system is provided for draining liquid accidentally spilled on a casing having a plurality of pushbuttons on a surface of the casing. An electronic apparatus may comprise a casing and a drainage system. The drainage system may be connected with the casing. The drainage system may include a liquid collecting basin, a drainage exit, and a liquid passageway. The liquid passageway may have a capillary surface and may lead the liquid from the liquid collecting basin to the drainage exit.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: June 12, 2012
    Assignee: Lenovo (Singapore) Pte. Ltd.
    Inventors: Yoshiharu Uchiyama, Akinori Uchino, Tsutomu Chonan, Hiroyuki Noguchi, Kimio Kumada
  • Patent number: 8092018
    Abstract: A non-contact ultrasonic tonometer for measuring intraocular pressure of an examinee's eye, in non-contact manner by use of an ultrasonic wave comprises: a probe including a vibrator for making the ultrasonic wave incident on the examinee's eye and a sensor for detecting the ultrasonic wave reflected from the examinee's eye; and an observation optical system for observing an anterior segment of the eye, wherein the probe is placed in an optical path of the observation optical system, and the observation optical system forms an image of the anterior segment through a surrounding region of the probe.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: January 10, 2012
    Assignee: Nidek Co., Ltd.
    Inventor: Tetsuyuki Miwa
  • Patent number: 8092019
    Abstract: A non-contact ultrasonic tonometer for measuring intraocular pressure of an examinee's eye in non-contact manner by use of an ultrasonic wave comprises: a probe including a vibrator for making the ultrasonic wave incident on the eye and a sensor for detecting the ultrasonic wave reflected from the eye; a detection unit which detects an alignment state of the probe with respect to the eye; a determination unit which determines whether the alignment state is proper or not based on a detection result of the detection unit; a trigger signal generation unit which generates a trigger signal to start measurement based on a determination result of the determination unit; and a control unit which controls the probe to emit the ultrasonic wave based on generation of the trigger signal.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: January 10, 2012
    Assignee: Nidek Co., Ltd.
    Inventor: Tetsuyuki Miwa
  • Patent number: 8070679
    Abstract: A computer-implemented method for accurate determination of intraocular pressure (IOP) and characterization of mechanical properties of a cornea is provided that includes measuring a cornea with a probe tonometer to produce at least force versus displacement data over a range of applied forces; and forming a model of corneal constitutive parameters, with a computer having a processor, based on the data obtained by the probe tonometer to more accurately determine IOP and characterize mechanical properties of the cornea, wherein the computer is coupled with the probe tonometer.
    Type: Grant
    Filed: July 21, 2008
    Date of Patent: December 6, 2011
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jamshid Ghaboussi, David A. Pecknold, Youssef Hashash, Tae-Hyun Kwon
  • Patent number: 7991473
    Abstract: Systems and methods are provided for graphically configuring leads for a medical device. According to one aspect, the system generally comprises a medical device and a processing device, such as a programmer or computer, adapted to be in communication with the medical device. The medical device has at least one lead with at least one electrode in a configuration that can be changed using the processing device. The processing device provides a graphical display of the configuration, including a representative image of a proposed electrical signal to be applied by the medical device between the at least one electrode of the medical device and at least one other electrode before the medical device applies the electrical signal between the at least one electrode and the at least one other electrode. In one embodiment, the graphical display graphically represents the lead(s), the electrode(s), a pulse polarity, and a vector.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: August 2, 2011
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Par Lindh, James Kalgren, Rene H. Wentkowski, John Lockhart
  • Patent number: 7935058
    Abstract: Systems and methods are provided for characterizing biomechanical properties of tissue within an eye. A perturbation component introduces a stress to the eye tissue. An imaging component is operative to obtain an image of the eye tissue. A first image of the tissue can be obtained prior to the introduction of the stress and a second image of the tissue can be obtained after the introduction of the stress. An image analysis component compares the first image and the second image as to determine at least one biomechanical property of the tissue.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: May 3, 2011
    Assignee: The Cleveland Clinic Foundation
    Inventors: William J. Dupps, Jr., Andrew M. Rollins, Matthew Ford
  • Publication number: 20110087086
    Abstract: A microprocessor-controlled tonometer measures both systole and diastole occurring in intraocular pressure so that this information can be used to estimate perfusion pressure. The microprocessor determines a ratio between ocular pulse amplitude and mean intraocular pressure, derives a multiplier from the ratio, multiplies the mean intraocular pressure by the multiplier to estimate mean central retinal artery pressure, and then estimates perfusion pressure by subtracting mean intraocular pressure from the estimate of central retinal artery pressure.
    Type: Application
    Filed: October 12, 2009
    Publication date: April 14, 2011
    Applicant: FALCK MEDICAL, INC.
    Inventors: Francis Y. Falck, JR., Robert W. Falck
  • Publication number: 20110015512
    Abstract: A measurement system takes measurements of intraocular pressure and displaced ocular volume for determination of aqueous outflow resistance A device with a ?gid outer wall, a flexible inner wall, and an inflatable bladder in between is placed over the eye A pressure measurement system is coupled to the bladder and is configured to measure a pressure of fluid within the bladder A hydraulic unit is coupled to the bladder and configured to control a flow of fluid between the bladder and an external reservoir, and to measure a change of volume in the bladder created by the pressure applied to the eye Both the pressure measurement system and hydraulic unit are directly controlled by and communicated with a microprocessor/computer In addition, the microprocessor computes the outflow resistance of the eye as a function of the pressure in the bladder and the change of volume in the bladder over time.
    Type: Application
    Filed: March 6, 2009
    Publication date: January 20, 2011
    Applicant: The Regents of the University of California
    Inventors: Tingrui Pan, James David Brandt
  • Patent number: 7798962
    Abstract: A method and apparatus for measuring corneal resistance to deformation use an empirically derived function wherein an inward applanation pressure P1 and an outward applanation pressure P2 obtained during a corneal deformation cycle caused by a fluid pulse are separately weighted so as to minimize dependence of the calculated corneal resistance factor (CRF) on intraocular pressure. In one embodiment, the function is optimized, at least in part, to maximize statistical correlation between the calculated corneal resistance factor (CRF) and central corneal thickness.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: September 21, 2010
    Assignee: Reichert, Inc.
    Inventor: David A. Luce
  • Patent number: 7783364
    Abstract: Systems and methods are provided for graphically configuring leads for a medical device. According to one aspect, the system generally comprises a medical device and a processing device, such as a programmer or computer, adapted to be in communication with the medical device. The medical device has at least one lead with at least one electrode in a configuration that can be changed using the processing device. The processing device provides a graphical display of the configuration, including a representative image of a proposed electrical signal to be applied by the medical device between the at least one electrode of the medical device and at least one other electrode before the medical device applies the electrical signal between the at least one electrode and the at least one other electrode. In one embodiment, the graphical display graphically represents the lead(s), the electrode(s), a pulse polarity, and a vector.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: August 24, 2010
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Par Lindh, James Kalgren, Rene H. Wentkowski, John Lockhart
  • Publication number: 20100145180
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Application
    Filed: November 17, 2009
    Publication date: June 10, 2010
    Inventor: Marcio Marc Abreu
  • Publication number: 20100069737
    Abstract: A non-contact ultrasonic tonometer for measuring intraocular pressure of an examinee's eye in a non-contact manner by use of an ultrasonic wave comprises: a probe that emits an ultrasonic beam to be allowed to enter the eye and detects the ultrasonic beam reflected by the eye; and an arithmetic section that determines the intraocular pressure by processing an output signal from the probe, the probe including a broadband air-coupled transducer that transmits and receives the ultrasonic beam having a broadband frequency component.
    Type: Application
    Filed: September 14, 2009
    Publication date: March 18, 2010
    Applicant: NIDEK CO., LTD.
    Inventors: Masayuki Jinde, Tetsuyuki Miwa, Kenichiro Makino
  • Patent number: 7654957
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: February 2, 2010
    Inventor: Marcio Marc Abreu
  • Patent number: 7648465
    Abstract: A method for direct indication of the IOP level without requiring an additional pressure transducer being introduced into the irrigation path. The method of the present invention estimates resistance ratio for a particular setup, and thus does not assume a typical value; the estimation is performed in a pre-operational configuration that is the closest possible to the surgical configuration.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: January 19, 2010
    Assignee: Alcon, Inc.
    Inventor: Raphael Gordon
  • Publication number: 20090306493
    Abstract: The arrangement in a tonometer has a probe that is brought into contact with the surface of the eye and the intraocular pressure in the eye is derived from the variations in the velocity of the probe. The probe is formed of a piece of a non-magnetic substance. The arrangement includes a holder located in the tubular component and attached to a shaft providing the force for the measurement, in which holder there is a guiding means for guiding a movement of the probe along an internal surface of the tubular component.
    Type: Application
    Filed: December 14, 2005
    Publication date: December 10, 2009
    Inventor: Antti Kontiola
  • Publication number: 20090275819
    Abstract: A non-contact ultrasonic tonometer for measuring intraocular pressure of an examinee's eye, in non-contact manner by use of an ultrasonic wave comprises: a probe including a vibrator for making the ultrasonic wave incident on the examinee's eye and a sensor for detecting the ultrasonic wave reflected from the examinee's eye; and an observation optical system for observing an anterior segment of the eye, wherein the probe is placed in an optical path of the observation optical system, and the observation optical system forms an image of the anterior segment through a surrounding region of the probe.
    Type: Application
    Filed: April 23, 2009
    Publication date: November 5, 2009
    Applicant: NIDEK CO., LTD.
    Inventor: Tetsuyuki Miwa
  • Publication number: 20090275820
    Abstract: A non-contact ultrasonic tonometer for measuring intraocular pressure of an examinee's eye in non-contact manner by use of an ultrasonic wave comprises: a probe including a vibrator for making the ultrasonic wave incident on the eye and a sensor for detecting the ultrasonic wave reflected from the eye; a detection unit which detects an alignment state of the probe with respect to the eye; a determination unit which determines whether the alignment state is proper or not based on a detection result of the detection unit; a trigger signal generation unit which generates a trigger signal to start measurement based on a determination result of the determination unit; and a control unit which controls the probe to emit the ultrasonic wave based on generation of the trigger signal.
    Type: Application
    Filed: April 23, 2009
    Publication date: November 5, 2009
    Applicant: NIDEK CO., LTD.
    Inventor: Tetsuyuki Miwa
  • Patent number: RE45013
    Abstract: A non-contact ultrasonic tonometer for measuring intraocular pressure of an examinee's eye, in non-contact manner by use of an ultrasonic wave comprises: a probe including a vibrator for making the ultrasonic wave incident on the examinee's eye and a sensor for detecting the ultrasonic wave reflected from the examinee's eye; and an observation optical system for observing an anterior segment of the eye, wherein the probe is placed in an optical path of the observation optical system, and the observation optical system forms an image of the anterior segment through a surrounding region of the probe.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: July 15, 2014
    Assignee: Nidek Co., Ltd.
    Inventor: Tetsuyuki Miwa