By Fluid Injection Of Radioactive Or Enhancing Agent Through Body Piercing Conduit Patents (Class 600/4)
  • Patent number: 11759222
    Abstract: A method for reshaping a nasal airway in a patient involves advancing an inflatable balloon of a reshaping device in an uninflated configuration into a nostril of the patient and between a nasal septum and a lateral wall of the nasal airway. The method then involves inflating the inflatable balloon to an inflated configuration to cause the inflatable balloon to contact nasal mucosa covering the nasal septum and the lateral wall, delivering energy from an energy delivery member attached to or inside of the inflatable balloon, and removing the reshaping device from the nasal airway.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: September 19, 2023
    Assignee: Aerin Medical Inc.
    Inventors: Scott J. Wolf, Andrew Frazier
  • Patent number: 11759361
    Abstract: A method of accommodating patient movement in a laser surgery system with a scanner. The scanner is configured to be coupled with an eye interface device and operable to scan an electromagnetic radiation beam in at least two dimensions in an eye interfaced with the eye interface device. The scanner and the eye interface device move in conjunction with movement of the eye. A first support assembly supports the scanner so as to accommodate relative movement between the scanner and the first support assembly parallel so as to accommodate movement of the eye. A beam source generates the electromagnetic radiation beam. The electromagnetic radiation beam propagates from the beam source to the scanner along an optical path having an optical path length that varies in response to movement of the eye.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: September 19, 2023
    Assignee: AMO Development, LLC
    Inventor: Phillip Gooding
  • Patent number: 11617834
    Abstract: The present disclosure relates to a drug delivery device, comprising a shell adapted to contain one of a plurality of medicament containers prefilled with different deliverable volumes of a medicament. The shell is transparent at least in an area adapted to contain the medicament container, and a label adapted to be arranged on the shell. The label comprises a foil having a first surface and a second surface, which is adapted to be connected to the shell. At least one cutout or transparent area is arranged in the foil adapted to be placed on the shell such that a medicament container arrangeable or arranged within the shell is visible through the cutout or transparent area. The cutout or transparent area exhibits a size adapted to allow inspection of the deliverable volume of medicament within the medicament container when the label is applied to the shell.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: April 4, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Uwe Dasbach
  • Patent number: 11318193
    Abstract: The present invention provides an immunomodulator for use in the treatment and/or control of a neoplastic disease in a patient intended to undergo immunogenic cell death therapy simultaneously, separately or sequentially with administration of the immunomodulator. The therapy can be selected from microwave irradiation, targeted radiotherapy, embolization, cryotherapy, ultrasound, high intensity focused ultrasound, cyberknife, hyperthermia, radiofrequency ablation, cryoablation, electrotome heating, hot water injection, alcohol injection, embolization, radiation exposure, photodynamic therapy, laser beam irradiation, and combinations thereof.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: May 3, 2022
    Inventors: Charles Akle, Satvinder Mudan, John Grange
  • Patent number: 10376602
    Abstract: Disclosed are compositions and methods for diagnosing eosinophilic esophagitis in a subject. Also disclosed are methods for monitoring the course of eosinophilic esophagitis in a subject before, during, and after treatment. In another aspect, disclosed is a method of diagnosing eosinophilic esophagitis or eosinophilic diseases in a subject, comprising detecting an eosinophil granule protein in the mucosal tissue of the esophagitis or other organs in a subject.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: August 13, 2019
    Inventors: Leonard F. Pease, Hedieh Saffari, Gerald J. Gleich, Kristin M. Leiferman, Kathryn A. Peterson, Russell Morris Condie
  • Patent number: 9789212
    Abstract: Disclosed are compositions and methods for diagnosing eosinophilic esophagitis in a subject. Also disclosed are methods for monitoring the course of eosinophilic esophagitis in a subject before, during, and after treatment.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: October 17, 2017
    Inventors: Leonard F. Pease, Hedieh Saffari, Gerald J. Gleich, Kristin M. Leiferman, Kathryn A. Peterson, Russell Morris Condie
  • Patent number: 9682192
    Abstract: Methods and systems for dispensing a fluid using an automated fluid delivery system are disclosed. A pump may be configured to force an aliquot of fluid into a fluid delivery channel. A processor may receive values of a property for the aliquot and the source of the aliquot. The processor may use the values to determine the volume of the aliquot. The determined volume is compared by the processor against an expected volume to establish the amount of fluid being pumped by the pump per unit, such as time or revolutions. The processor controls operation of the pump to dispense a predetermined dose based on the amount of fluid being pumped by the pump per unit.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: June 20, 2017
    Inventors: Charles Marsh, Larry McCutchan
  • Patent number: 9662477
    Abstract: The present technology is directed to introducer needle assemblies comprising a tapered needle; as well as to kits comprising a tapered needle, a guidewire and a dilator and sheath; as well as to methods of introducing a dilator to the interior of a patient's body as part of an interventional procedure.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: May 30, 2017
    Inventors: Yasutake Yamada, Linda E. Trask
  • Patent number: 9627097
    Abstract: Systems, apparatus and methods are provided through which an injector system automates a process of injecting an individual dose from a multiple dose of a radiotracer material. In some embodiments, the injector system includes a first dose calibrator system that receives a multidose vial of a radiotracer, a second dose calibrator system, an injection pump and an intravenous needle. In some embodiments, the first dose calibrator system and the multidose vial have an integrated shape. In some embodiments, the first dose calibrator system includes a pneumatic arm that receives the multidose vial.
    Type: Grant
    Filed: March 2, 2004
    Date of Patent: April 18, 2017
    Assignee: General Electric Company
    Inventors: Mark Alan Jackson, Paritosh Jayant Dhawale, Hernan Rodrigo Lara, Michael Brussermann, Ulrich Ketzscher
  • Patent number: 9299468
    Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer includes pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: March 29, 2016
    Assignee: Bracco Diagnostics Inc.
    Inventors: Stephen E. Hidem, Aaron M. Fontaine, Janet L. Gelbach, Patrick M. McDonald, Kathryn M. Hunter, Rolf E. Swenson, Julius P. Zodda
  • Patent number: 9283290
    Abstract: Compositions, articles, and methods for treating and imaging vulnerable plaque and other inflamed regions in a patient rely on delivery of a conversion electron emitting source (CEES) to a body location. The CEES may be delivered by coupling to a substance which preferentially binds to vulnerable plaque or other inflammatory marker. Alternatively, the CEES can be delivered on a catheter, scaffold, or other device.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: March 15, 2016
    Inventors: Gilbert R. Gonzales, Nicholas Chronos
  • Patent number: 9233231
    Abstract: A breast cavity spacer device, such as for use with a percutaneous lumpectomy, is provided. The device includes a body having a projection on one end. The body has a bore extending there through. A catheter is disposed at least partially within the bore. A balloon member is fluidly coupled on one end of the catheter, the balloon member having an elliptical shape.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: January 12, 2016
    Inventors: Steven Michael Schonholz, James C. McKeon, Glenn E. Vallee, Christopher Baltazar, Brian Kozniewski, Stephen Lauzon, Teresa Mitchell, Yah Laetitia Sangne, Robert T. T. Gettens
  • Patent number: 9123449
    Abstract: Infusion system configurations and assemblies facilitate routing of infusion circuit tubing lines. Tubing lines are routed into and out from compartments of a shielding assembly for the infusion system, at locations which prevent kinking and/or crushing of the lines, and/or provide for ease in assembling the circuit. A plurality of the lines may be held together by a support frame to form a disposable infusion circuit subassembly, that can further facilitate routing of the lines.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: September 1, 2015
    Assignee: Bracco Diagnostics Inc.
    Inventors: Charles R. Quirico, Ernest Balestracci, Rolf E. Swenson, Daniel D. Darst, Eric J. Krause, Vishal N. Lokhande, Jacob S. Childs
  • Patent number: 9039592
    Abstract: A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are provided herein. A fluid path set comprising a confluence valve, a four-way valve, and one or more tubing sections which are designed to place some combination of a radiopharmaceutical source, a medical fluid source, and a pharmaceutical agent source in sterile fluid communication with a patient or a waste receptacle. Also provided are holders for the fluid path set, and a sterile fluid delivery kit comprising the holder and fluid path set. A fluid delivery system may accept the holder with the fluid path set installed and various sources of radiopharmaceuticals, pharmaceuticals, and medical fluids. The fluid delivery system allows for automated mixing and delivery of exact amounts of these agents to a patient while improving efficiency and safety, and reducing waste.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 26, 2015
    Assignee: Bayer Medical Care Inc.
    Inventors: Ryan Kaintz, Jason L. Bazala, Douglas DeScalzi, Scott R. Griffith, Bruno Fazi, Charles Marsh, James A. Agamaite, Matthew Sass, Carl Michael Benson, Matthew Beale, Courtney N. Southard
  • Publication number: 20150087960
    Abstract: Systems and methods of treating a patient, including a proton treatment system having a proton delivery unit to direct protons to a target area of a patient, the proton treatment system including a positron emission tomography (PET) system having a detector unit to scan for radiotracers introduced into a patient's body, a processing unit to generate location information corresponding to a target area of the patient based on a scanned radiotracer, a guidance unit to receive the location information from the PET system and to instruct the proton delivery unit to direct protons to the target area according to the location information.
    Type: Application
    Filed: September 22, 2014
    Publication date: March 26, 2015
    Inventor: Jon Treffert
  • Publication number: 20150025296
    Abstract: A method of delivering a radioactive liquid includes, performing an initialization, including; extracting at least a first amount of a radioactive liquid from a source of radioactive liquid, measuring a radioactivity level for the first amount of radioactive liquid, and performing a calibration phase. The calibration phase includes, extracting a second amount of radioactive liquid from the source of radioactive liquid wherein the second amount is calculated based on the radioactivity level of the first amount to provide a total dose of radioactive liquid having a predetermined radioactivity level, and delivering the total dose and performing at least one more calibration and delivery phases.
    Type: Application
    Filed: October 3, 2014
    Publication date: January 22, 2015
    Inventors: Alfred Buck, Bruno Weber
  • Publication number: 20150018597
    Abstract: The present invention provides a kit for the delivery a therapeutic agent to an organ blood flow and the removal of the excess of said therapeutic agent from said organ blood flow, said kit comprises: (a) the therapeutic agent, (b) a first retrievable medical device (26), for delivering said therapeutic agent into the organ inflow, (c) a second retrievable medical device for isolating the organ outflow vessel and (d) a separation device (25) comprising at least one filter able to separate the therapeutic agent excess from the organ outflow, having an inlet (38) for the organ outflow having a therapeutic agent excess and an outlet (39) for filtered organ outflow.
    Type: Application
    Filed: March 1, 2013
    Publication date: January 15, 2015
    Inventors: Joop Fierens, Kevin Jason Nackard, Eric Thierry Jean Marcoux, Emmanuel J. Bartholome
  • Publication number: 20140341845
    Abstract: Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.
    Type: Application
    Filed: August 4, 2014
    Publication date: November 20, 2014
    Applicant: lmmunolight, LLC.
    Inventor: Frederic A. BOURKE, JR.
  • Patent number: 8880457
    Abstract: A method for improved, automated analysis of a data set improves the reliability of the data set by comparing the data set with a model of similar data. The method may be used in applications such as medical imaging, clinical trial participant selection, marketing, security, traffic control, and other applications.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: November 4, 2014
    Assignee: Allegheny-Singer Research Institute
    Inventor: Mark Doyle
  • Publication number: 20140316186
    Abstract: The present invention is directed towards isolated antibodies that bind to GRP78 and TIP-1.
    Type: Application
    Filed: January 28, 2014
    Publication date: October 23, 2014
    Inventors: Dennis E. Hallahan, Heping Yan
  • Publication number: 20140257015
    Abstract: Methods and systems for automatically and dynamically determining a dose of a radiopharmaceutical are disclosed. The dose may be determined based on, among other things, radiopharmaceutical information associated with at least one source of a radiopharmaceutical, patient information and schedule information. An estimated radioactivity level may be determined based on an initial radioactivity level, a delivery time, a radioactivity decay rate, and an anticipated arrival time. A volume of the radiopharmaceutical to inject into a patient to deliver a dose of radioactivity may be determined based on the estimated radioactivity level and patient dosing information. An infusion apparatus may operate to inject the patient with the volume of the radiopharmaceutical.
    Type: Application
    Filed: March 7, 2013
    Publication date: September 11, 2014
    Applicant: MEDRAD, INC.
    Inventors: James A. AGAMAITE, Larry McCUTCHAN
  • Publication number: 20140257014
    Abstract: Methods and systems for dispensing a radionuclide are disclosed. A processor may receive one or more physiological signals for a patient from one or more physiological parameter sensors. The processor may compare the physiological signals with one or more threshold values. The processor may cause an injector device to dispense the radionuclide in response to the one or more physiological signals meeting or exceeding the one or more threshold values. The threshold values may be determined at least in part based on one or more characteristics of the patient.
    Type: Application
    Filed: March 7, 2013
    Publication date: September 11, 2014
    Applicant: MEDRAD, INC.
    Inventor: Larry McCUTCHAN
  • Publication number: 20140249350
    Abstract: Apparatus for fractionation and infusion of radiopharmaceuticals, including a fractionation unit (1) for fractionation into a number of calibrated doses of an amount of radioactive liquid contained in a multidose vial (VE), and a unit (2) for transferring the doses from the fractionation unit (1) to a device (3) for administration thereof to a patient (S), and further including a controlled-atmosphere ventilated chamber (4) containing the unit (2) for transfer of the doses and the connections (21, 23, 25) to a line (11) for connection to the administering device.
    Type: Application
    Filed: October 11, 2012
    Publication date: September 4, 2014
    Applicant: TEMA SINERGIE S.P.A.
    Inventor: Luciano Piancastelli
  • Publication number: 20140249349
    Abstract: A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are provided herein.
    Type: Application
    Filed: March 1, 2013
    Publication date: September 4, 2014
    Applicant: MEDRAD, INC.
    Inventor: Charles MARSH
  • Publication number: 20140235924
    Abstract: The invention provides a method for the treatment of soft tissue disease in a mammalian subject (preferably a human or canine subject), said method comprising administering to said subject a therapeutically effective quantity of a soft tissue targeting complex of thorium-227 and a complexing agent, wherein said quantity is such that an acceptably non-myelotoxic quantity of radium-223 is generated in vivo by nuclear decay of the administered thorium-227.
    Type: Application
    Filed: February 19, 2014
    Publication date: August 21, 2014
    Applicant: Algeta ASA
    Inventors: Roy H. LARSEN, Oyvind S. BRULAND
  • Publication number: 20140228617
    Abstract: Methods and systems for monitoring an automated radiopharmaceutical infusion apparatus are disclosed. A user interface graphically representing infusion apparatus components may be presented on a display device. Multiple sensors may be arranged within an infusion apparatus to measure property information associated with infusion apparatus components, including fluid pathways. The property information may include radioactivity and flow information. The property information may be compared with expected results. If the property information does not match the expected results, a fault condition may be indicated on the display device. The user interface may provide information and/or functions to manage the fault conditions.
    Type: Application
    Filed: February 11, 2013
    Publication date: August 14, 2014
    Applicant: MEDRAD, INC.
    Inventor: James A. AGAMAITE
  • Patent number: 8753255
    Abstract: Compositions, articles, and methods for treating and imaging vulnerable plaque and other inflamed regions in a patient rely on delivery of a conversion electron emitting source (CEES) to a body location. The CEES may be delivered by coupling to a substance which preferentially binds to vulnerable plaque or other inflammatory marker. Alternatively, the CEES can be delivered on a catheter, scaffold, or other device.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: June 17, 2014
    Assignee: Clear Vascular Inc.
    Inventors: Gilbert R. Gonzales, Nicolas Chronos
  • Patent number: 8740873
    Abstract: The disclosure is directed to radiation catheter devices, methods for controlled application of irradiation to tissue at a body site, such as a cavity formed after removal of tissue, e.g. cancer, using such radiation catheter devices, solutions for forming a more lubricious luminal surface and method for lining lumens of such devices to improve the frictional characteristics thereof. The catheter device includes a flexible elongated shaft which is formed of low durometer polymeric material, which can be readily folded or coiled for securing the shaft to or under the skin of the patient and a radiation lumen lined with high durometer polymeric material to improve the frictional characteristics. The elongated shaft has at least one inner lumen for receiving a radiation source which has a layer of high durometer polymeric material that provides lower surface friction to facilitate advancement of a radiation source therein.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: June 3, 2014
    Assignee: Hologic, Inc.
    Inventors: Michael L. Jones, Frank R. Louw
  • Publication number: 20140148687
    Abstract: Method and medical devices for generating and stabilizing micro or nano bubbles, and systems and methods for therapeutic applications using the bubbles, is provided. Two novel bubble generating means are provided: in-line capillary tubes and mix chambers flow focusing, and cross flow bubble generation with optimized bubble detachment means. A method and medical device to stabilize bubble sizes and improve bubble size homogeneity through rectified diffusion is disclosed. A method and system to facilitate acoustic activation of therapeutic agents using ultrasound energy is provided.
    Type: Application
    Filed: February 4, 2014
    Publication date: May 29, 2014
    Applicant: Artenga Inc.
    Inventors: James A. Keenan, Junjie Gu, Philippe Joel Genereux, Adrian T. Bienkinsop, David H. Gerwing, Sebastien Roy Fournier, Sarah Katherine Dobbin
  • Patent number: 8734315
    Abstract: An apparatus for filling a medical instrument with a radioactive substance, said apparatus including a housing designed to receive a syringe and at least part of a medical instrument and to shield against radioactive radiation, further including a means to take up a receptacle for a radioactive substance.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: May 27, 2014
    Assignee: Isotopen Technologien Munchen AG
    Inventors: Michael Schilp, Nikula Tuomo, Oliver Buck
  • Patent number: 8702580
    Abstract: A method for planning to treat tissue by administering a substance which emits energy or can interact with administered energy to a body, such as body tissue, wherein a dispersion of the substance in the body is simulated, and to a system or device for planning administering a substance and administering energy to a body or in body tissue.
    Type: Grant
    Filed: October 6, 2005
    Date of Patent: April 22, 2014
    Assignee: Brainlab AG
    Inventors: Andreas Hartlep, Christoph Pedain
  • Publication number: 20140100409
    Abstract: A method and apparatus for treating a tumor in a patient. In one embodiment, the method comprises the steps of: dosing the patient with a substituted tumor-specific agent and irradiating the tumor with energetic ions, the ions having sufficient energy to penetrate into the tumor and cause nuclear fusion reactions, but not to pass through the tumor. In one embodiment, the substituted tumor-specific agent incorporates deuterium. In this embodiment, the energetic ions are tritium nuclei. In this embodiment, the apparatus comprises a tritium ion source, an accelerator producing an ion beam, a scanning mechanism, and a plurality of neutron detectors positioned adjacent to the patient. The tritium ion beam is programmed to traverse the site of the tumor with tritium ions having energy sufficient to penetrate into the tumor and cause nuclear fusion reactions, but not pass through the tumor.
    Type: Application
    Filed: September 19, 2013
    Publication date: April 10, 2014
    Inventor: Milford Burton Kime
  • Publication number: 20140088408
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Inventors: Dennis E. Hallahan, Raymond Mernaugh
  • Publication number: 20140039237
    Abstract: A medication dispensing device includes a medication bottle, a perfusion device, a filter and a dispensing needle. The dispensing needle includes a lower end being shrill, smooth and seamless and puncturing into the plug of the medication bottle. The dispensing needle includes a passageway therein, and includes an opening and a groove on the side wall of the dispensing needle. The dispensing needle can puncture into the plug of the medication bottle without creating any scraps stuck in the opening of the passageway or dropping into the medication bottle. The groove can release the air and pressure of the medication bottle when the pressure in the medication bottle increases during the injection of the medication solution. Accordingly, the smoothness of the dispensation of the medication solution is improved, and the contamination of the medication solution can be avoided.
    Type: Application
    Filed: August 6, 2012
    Publication date: February 6, 2014
    Inventor: MING-HSIN LI
  • Patent number: 8641592
    Abstract: A method and device for image guided dynamic radiation treatment of prostate cancer and other pelvic lesions including: 1) a unique fan geometry of radiation sources; 2) a special collimation method and apparatus to sculpt the radiation borders; 3) an integrated three-dimensional imager and a special tissue interface imaging system to locate and track critical boundaries in real-time; 4) a dynamic patient support system, which is shared by the said imager and the irradiation system; and 5) motorized custom shielding filters to further protect neighboring normal tissues such as the kidneys and femoral heads. The fan geometry utilizes a plural number of radiation sources arranged specifically for irradiating tumors in the human pelvis while not harming critical structures, and the collimation sculpts the radiation borders using motorized shields for different sensitive structures.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: February 4, 2014
    Inventor: Xinsheng Yu
  • Patent number: 8641593
    Abstract: Disclosed herein is a system for transferring brachytherapy elements to a needle, such as seeds, connectors, spacers, and strands. The system comprises a transfer device and, optionally, a stylet and a rack configured to hold one or more transfer devices.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: February 4, 2014
    Assignee: C. R. Bard, Inc.
    Inventors: Christopher Drobnik, Michael Drobnik, Breese Watson
  • Publication number: 20140018606
    Abstract: Provided herein is the compound RK-33, or a salt, solvate, stereoisomer, or derivative thereof, which is shown to be an inhibitor if the DEAD box helicase DDX3, in mammalian cells. RK-33 is also provided herein for use as a radiation dose sensitizer in a subject suffering from a proliferative disease and undergoing radiation therapy. Methods of treatment of proliferative diseases, such as cancer with a combination of RK-33 and radiotherapy methods such as stereotactic ablative radiotherapy (SABR) are also provided.
    Type: Application
    Filed: March 9, 2012
    Publication date: January 16, 2014
    Applicant: The Johns Hopkins University
    Inventors: Venu Raman, Phuoc Tran
  • Publication number: 20130331634
    Abstract: A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are provided herein.
    Type: Application
    Filed: March 14, 2013
    Publication date: December 12, 2013
    Applicant: MEDRAD, INC.
    Inventors: Ryan KAINTZ, Jason L. BAZALA, Douglas DeSCALZI, Scott R. GRIFFITH, Bruno FAZI, Charles MARSH, James A. AGAMAITE, Matthew SASS, Carl Michael BENSON, Matthew BEALE, Courtney N. SOUTHARD
  • Publication number: 20130331635
    Abstract: A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are described herein. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, and other devices and methods are also described.
    Type: Application
    Filed: March 15, 2013
    Publication date: December 12, 2013
    Applicant: MEDRAD, INC.
    Inventors: Raymond C. HOFFMAN, Barry L. TUCKER, David H. BERRY, Martin J. URAM, Douglas DeSCALZI, Arthur E. UBER, III
  • Patent number: 8567410
    Abstract: The present invention relates to aerosols containing magnetic particles, wherein the aerosols comprise magnetic particles and a pharmaceutical active agent. The invention furthermore relates to the use of such aerosols containing magnetic particles for directed magnetic field-guided transfer of the active agents contained therein in aerosol therapy.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: October 29, 2013
    Assignee: Ethris GmbH
    Inventors: Carsten Rudolph, Joseph Rosenecker
  • Publication number: 20130267758
    Abstract: Methods and devices for minimally-invasive delivery of radiation to the posterior portion of the eye including a cannula comprising a distal portion connected to a proximal portion and a means for advancing a radionuclide brachytherapy source (RBS) toward the tip of the distal portion; a method of introducing radiation to the human eye comprising inserting a cannula between the Tenon's capsule and the sclera of the human eye and emitting the radiation from the cannula on an outer surface of said sclera.
    Type: Application
    Filed: April 29, 2013
    Publication date: October 10, 2013
    Inventors: Luca Brigatti, Russell J. Hamilton, Laurence J. Marsteller, Michael Voevodsky
  • Publication number: 20130259800
    Abstract: The invention described herein pertains to the use of oxazolidinone antibiotics, alone or in combination, in the treatment of cancer. In particular, the invention pertains to the treatment of malignant gliomas, thyroid cancer or melanoma, or borderline forms of malignant glioma, thyroid cancer or melanoma.
    Type: Application
    Filed: December 15, 2011
    Publication date: October 3, 2013
    Applicant: BIOVISTA, INC.
    Inventors: Andreas Persidis, Spyros Deftereos
  • Publication number: 20130225903
    Abstract: A pierce and fill connector cap for a vial sealed by an elastomeric septum includes a vial collar and a needle holder. The vial collar body defines a collar aperture to be positioned in overlying registry with the septum of the vial, and the needle holder includes a needle holder body providing a means for holding an elongate needle in registry with the collar aperture. The needle holder body being moveable with respect to said vial collar between a first position spaced from the vial collar and a second position proximate the vial collar, such that a needle held by the needle holder will puncture through the vial septum.
    Type: Application
    Filed: November 1, 2011
    Publication date: August 29, 2013
    Inventors: Xavier Franci, Philippe Dumont, Svein-Erik Lindgaard
  • Patent number: 8500693
    Abstract: The present invention relates to a device for automatic injection of a product, comprising: a body (3) housing a container, the container being movable relative to said body between an initial position, to an insertion position; a safety shield (26) movable with respect to said container and said body between an insertion position to a protection position, when the user removes the device from an injection site; an external socket (48) receiving the body and provided with selection means (53) which can be placed by a user: either in a first position, in which the body (3) and the external socket (48) are bound to each other, the safety shield extending beyond the distal end of both said body and said external socket in the protection position; or in a second position, in which the external socket (48) is able to move axially in the distal direction with respect to the body (3), both the safety shield and the external socket extending beyond the distal end of said body, in the protection position.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: August 6, 2013
    Assignee: Becton Dickinson France
    Inventor: Lionel Maritan
  • Publication number: 20130123567
    Abstract: A method for planning and monitoring radio pharmaceutical usage during a plurality of radio pharmaceutical injection procedures includes: providing a schedule of the plurality of radio pharmaceutical injection procedures to produce a planned patient schedule; based on the planned patient schedule, calculating a multi-dose container configuration for use during the plurality of radio pharmaceutical injection procedures; transferring the planned patient schedule to a radio pharmaceutical fluid delivery system; loading the multi-dose patient configuration into the radio pharmaceutical fluid delivery system; and conducting the plurality of radio pharmaceutical injection procedures based on the planned patient schedule.
    Type: Application
    Filed: June 3, 2011
    Publication date: May 16, 2013
    Inventors: James A. Agamaite, Scott R. Griffith, Douglas Descalzi, Charles Marsh
  • Patent number: 8439815
    Abstract: A medical unit includes a shielded enclosure (2) in which are accommodated:—elements (13) for supporting a container (12) including a source or a generator of injectable radioactive product (11),—elements (10) for supporting a syringe (6),—a device (3) of the activimeter type, and—a system of pipes (9, 20, 23, 24) associated with at least one valve (15). The syringe support (10), the valve (15) and the radioactive source support (13) are arranged vertically relative to one another, respectively from top to bottom, the syringe support (10) being arranged to support the syringe (6) with the plunger (8) thereof oriented upward. The valve (15) and the syringe plunger (8) can be operated so as to ensure the withdrawal, dilution and injection operations.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: May 14, 2013
    Assignee: Lemer Protection Anti-X Par Abreviation Societe Lemer Pax
    Inventor: Pierre-Marie Lemer
  • Publication number: 20130109907
    Abstract: A cartridge for radiopharmaceutical packaging includes a low UV-absorbing plastic barrel, closed at one end by a cap and at the other by a piston. A shoulder cooperates with the barrel in a double-level snap-on system with a cavity cooperating with an injection fitting sleeve to make a seal. At a first end the cap has a peel-off porous liner covering the cavity. Radial fins protrude inside the cavity, for screwing the injection fitting and second radial fins protrude outside of the cap to fix to a cartridge protection shield. A second end minimizes a shadow area of UV flash lamp sterilization and ensures clearance for inserting an injection spike. The second end has a reduced wall thickness pierced by the spike during set up for dispensing of the pharmaceutical. An external cylindrical zone at the second end ensures leak tightness between the cap and the barrel.
    Type: Application
    Filed: December 7, 2012
    Publication date: May 2, 2013
    Applicant: TRASIS S.A.
    Inventor: TRASIS S.A.
  • Publication number: 20130079581
    Abstract: A system and method for monitoring progress of a radiopharmaceutical injection procedure includes: measuring and monitoring radiopharmaceutical activity of a radiopharmaceutical remaining in at least a portion of a disposable administration set used with a radiopharmaceutical fluid delivery system; and displaying the radiopharmaceutical activity remaining in at least the portion of the disposable administration set to an operator.
    Type: Application
    Filed: June 6, 2011
    Publication date: March 28, 2013
    Inventors: James A. Agamaite, Scott R. Griffith, Douglas Descalzi, Charles Marsh
  • Patent number: 8303477
    Abstract: A brachytherapy treatment device includes an insertion member, an expandable chamber, and first and second immiscible fluids. The insertion member has proximal and distal ends. The expandable chamber is disposed on the distal end of the insertion member and has an inner surface defining a three-dimensional volume. First and second immiscible fluids are disposed within the expandable chamber and have different radiation absorption properties. At least one of the first and second immiscible fluids forms a fluid radiation shield having a predetermined orientation within the three-dimensional volume. First and second immiscible fluids may have different densities and utilize fluid buoyancy to form an symmetric fluid radiation shield to create an asymmetric radiation dosing profile relative to an inner boundary of a treatment site.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: November 6, 2012
    Assignee: Cytyc Corporation
    Inventor: Gregory T. Martin
  • Publication number: 20120215052
    Abstract: A medical apparatus for effecting radiation treatment on a pre-selected anatomical portion of an animal body is disclosed. The medical apparatus may include a plurality of treatment channels configured to be positioned adjacent a body tissue and a plurality of delivery channels coupled to a corresponding number of treatment channels. The medical apparatus may also include a plurality of source channels configured to receive one or more energy sources, a tracking channel configured to receive a tracking element, and a connecting element configured to connect each delivery channel with either one of the plurality of sources channels or the tracking channel.
    Type: Application
    Filed: February 7, 2012
    Publication date: August 23, 2012
    Applicant: Nucletron B.V.
    Inventors: Johann KINDLEIN, Arie Luite Visscher, Johan Henning, Wouter Peter Engels