Radioactive Substance Applied To Body For Therapy Patents (Class 600/1)
  • Patent number: 10328282
    Abstract: A system and methods are provided for generating intensity modulated proton therapy plans robust to various kinds of delivery uncertainties with the capability for treatment planners to control the balance between plan quality and robustness. The system obtains a representation of a subject and a proton beam configuration that describes a number of beamlets and their respective arrangement. The system computes an objective function, in the treatment planning system, first part of which is about dose deviations from the prescribed dose in the target volumes, second part of which is about dose deviations from the dose constraint in the non-target volumes, and computing dose volume constraints for targets using a probability to control the dose distribution in the target volumes to be between a lower threshold and an upper threshold. Based on this information, the system obtains a robust chance-constrained treatment planning model with a user-adjustable tolerance level.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: June 25, 2019
    Assignees: Mayo Foundation for Medical Education and Research, Arizona Board of Regents on behalf of Arizona State University
    Inventors: Yu An, Jianming Liang, Wei Liu
  • Patent number: 10299740
    Abstract: Various methods and systems are provided for collision avoidance in cone-beam computed tomography (CT) systems. In one embodiment, a method for an imaging apparatus comprises calculating a likelihood of a collision between the imaging apparatus and a subject and/or its support based on a model of the subject, performing a scan of the subject responsive to the likelihood below a threshold, and not performing the scan otherwise. In this way, collisions between the patient and the imaging apparatus can be avoided.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: May 28, 2019
    Assignee: General Electric Company
    Inventors: Thomas Mc Carthy, Yves Lucien Trousset
  • Patent number: 10300303
    Abstract: An image-guided therapy delivery system includes a therapy generator configured to generate a therapy beam directed to a time-varying therapy locus within a therapy recipient, an imaging input configured to receive imaging information about a time-varying target locus within the therapy recipient, and a therapy controller. The therapy generator includes a therapy output configured to direct the therapy beam according to a therapy protocol. The therapy controller is configured to automatically generate a predicted target locus using information indicative of an earlier target locus extracted from the imaging information, a cyclic motion model, and a specified latency, and automatically generate an updated therapy protocol to align the time-varying therapy locus with the predicted target locus.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 28, 2019
    Assignees: Elekta LTD., Elekta, Inc.
    Inventors: Rupert Archie Brooks, Michel Moreau, Leila Pishdad
  • Patent number: 10265406
    Abstract: The present application relates to a pharmaceutical composition comprising biocompatible nanoparticles or nanoparticles aggregates which allows the appropriate delivery of said biocompatible nanoparticles or nanoparticles aggregates to a target site in a subject in need thereof. The composition indeed allows an accumulation of the biocompatible nanoparticles or nanoparticles aggregates it comprises into the targeted tissue of the subject of at least 4 milligram (mg) nanoparticles or nanoparticles aggregates per gram (g) of targeted tissue when at least 0.1 g of the pharmaceutical composition per kilogram (kg) of body weight is injected intravenously (IV) or intraarterially (IA) into said subject.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: April 23, 2019
    Assignee: NANOBIOTIX
    Inventors: Agnes Pottier, Laurent Levy, Matthieu Germain
  • Patent number: 10254739
    Abstract: An example system includes: a magnet including one or more coils to conduct current to generate a magnetic field, with the magnetic field to affect output of radiation to a target; and one or more actuators, with an actuator among the one or more actuators being at least part of a physical coupling to the one or more coils, and with the actuator being controllable to move the one or more coils via the physical coupling based on movement of the magnet.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: April 9, 2019
    Assignee: Mevion Medical Systems, Inc.
    Inventors: Mark R. Jones, Mark Robinson, Ken Yoshiki Franzen
  • Patent number: 10238892
    Abstract: A radiotherapy treatment verification and quality assurance method may include receiving at least one set of first medical images of at least a portion of a patient. A three-dimensional model of the portion of the patient may be created based on the at least one set of first medical images. At least one dosimeter may be inserted into at least a portion of the model. The dosimeter is configured to measure exposure to radiation. The model may be irradiated in accordance with a radiotherapy treatment plan created by a treatment planning system. A readout of the model may be taken or performed to measure in three-dimensions a delivered radiation doses distribution.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: March 26, 2019
    Inventors: Evangelos T. Pappas, Thomas G. Maris
  • Patent number: 10232192
    Abstract: A planning image memory stores a volume diagnostic image. A user inputs data defining clinical objectives including organs-at-risk with a user interface device. An auto-planning module generates a candidate treatment plan. A trade-off module having a processor evaluates the treatment plan against the clinical objectives. When one or more objectives is not met, the trade-off module performs a trade-off analysis to determine an effect on other clinical objectives and generates at least one trade-off treatment plan which more closely meets the not met objectives. The candidate and at least one trade-off plan are displayed on a display device and/or analyzed by the processor and a final treatment plan is selected from the at least one trade-off or candidate treatment plan.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: March 19, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Karl Antonin Bzdusek, Sankara Hari Gopalakrishnan, Prashant Kumar
  • Patent number: 10226643
    Abstract: A control circuit utilizes patient information and treatment-platform information to optimize a radiation-treatment plan by permitting isocenters of various radiation-treatment fields as comprise parts of a same treatment plan to not be coincidental with one another to thereby yield an optimized treatment plan. The patient information can pertain to one or more physical aspects of the patient as desired. By one approach, the foregoing can comprise scattering the isocenters of the various radiation-treatment fields around a predetermined point (such as, for example, the center of the treatment volume and/or some or all of the beams). This approach can comprise causing an area of highest energy flux for a given field to be non-coincident for at least some of the radiation-treatment fields as are specified by the radiation-treatment plan.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: March 12, 2019
    Assignee: Varian Medical Systems International AG
    Inventors: Viljo Petäjä, Perttu Niemelä, Esa Kuusela
  • Patent number: 10213626
    Abstract: The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: February 26, 2019
    Inventors: Vladimir Balakin, Stephen L. Spotts
  • Patent number: 10195466
    Abstract: The described invention provides methods for irradiating skin cancer cells, such as melanoma cells, at a high radiation rate (e.g., of 2,400 mu/min) and a modest total dose (e.g., of 0.5 Gy) to treat skin cancer or induce apoptosis in skin cancer cells. The radiation may be administered in a plurality of treatments and used in conjunction with chemotherapy.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: February 5, 2019
    Assignee: HACKENSACK UNIVERSITY MEDICAL CENTER
    Inventors: K. Stephen Suh, Sreeja Sarojini, Mehmet Tuna, Joseph Barbiere, Alois M. Ndlovu, Andrew L. Pecora, Anthony Ingenito
  • Patent number: 10175219
    Abstract: A method of sensing radionuclides in cells is provided that includes exposing a cell of interest to a radiolabeled molecule, encapsulating the cell of interest with a chemical sensor in an encapsulant to hold the cell of interest and the chemical sensor in proximity, where the radiolabeled molecule decays to emit an energetic particle, and detecting a fluorescence or optical absorption signal in the chemical sensor induced by the radio molecule decay, using an illumination source and a detector, where single-cell analysis with the radiolabeled molecule is performed.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: January 8, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Guillem Pratx, Silvan Tuerkcan
  • Patent number: 10173075
    Abstract: An ophthalmic radiation device having a substantially light-transparent wand configured to emit light propagating through the wand light from a series of illumination ports at least partially circumscribing a radioactive source disposed in the holder, thereby providing a visual reference for identifying a position of the radioactive source.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: January 8, 2019
    Assignee: IP LIBERTY VISION CORPORATION
    Inventors: Paul T. Finger, Toby Welles
  • Patent number: 10166143
    Abstract: A light-guided, ophthalmic-treatment-system for administering therapeutic agents to, into or through the scleral wall of the eye globe using any one of a variety of therapeutic applicators in conjunction with either transcorneal or transpupillary viewing methods or both.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: January 1, 2019
    Assignee: IP LIBERTY VISION CORPORATION
    Inventors: Paul T. Finger, Toby Welles
  • Patent number: 10159852
    Abstract: Described herein are systems and methods for positioning a radiation source with respect to one or more regions of interest in a coordinate system. Such systems and methods may be used in emission guided radiation therapy (EGRT) for the localized delivery of radiation to one or more patient tumor regions. These systems comprise a gantry movable about a patient area, where a plurality of positron emission detectors, a radiation source are arranged movably on the gantry, and a controller. The controller is configured to identify a coincident positron annihilation emission path and to position the radiation source to apply a radiation beam along the identified emission path. The systems and methods described herein can be used alone or in conjunction with surgery, chemotherapy, and/or brachytherapy for the treatment of tumors.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: December 25, 2018
    Assignee: RefleXion Medical, Inc.
    Inventors: Samuel Mazin, Akshay Nanduri
  • Patent number: 10149654
    Abstract: This invention relates to a multiple frame imaging system including radiation source, a detector having an input area, a monitor configured to display detected images, means for determining at least one Region of Interest (ROI) of an object on the displayed image, and a collimator having means for projecting the at least one region of interest (ROI) on at least one selected fraction of the input area exposed by the x-ray source. The collimator including at least three essentially non-overlapping plates mounted in a plane generally parallel to the detector input surface plane, each plate includes a first edge in contact with an edge of a first neighboring plate and a second edge adjacent to the first edge in contact with an edge of a second neighboring plate; and means for moving each one of the plates.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: December 11, 2018
    Assignee: CONTROLRAD SYSTEMS. INC.
    Inventors: Haim Zvi Melman, Liron Melman, Nir Eden, Gilad Nave-Frost, Allon Guez
  • Patent number: 10143857
    Abstract: Described herein are systems and methods for positioning a radiation source with respect to one or more regions of interest in a coordinate system. Such systems and methods may be used in emission guided radiation therapy (EGRT) for the localized delivery of radiation to one or more patient tumor regions. These systems comprise a gantry movable about a patient area, where a plurality of positron emission detectors, a radiation source are arranged movably on the gantry, and a controller. The controller is configured to identify a coincident positron annihilation emission path and to position the radiation source to apply a radiation beam along the identified emission path. The systems and methods described herein can be used alone or in conjunction with surgery, chemotherapy, and/or brachytherapy for the treatment of tumors.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: December 4, 2018
    Assignee: RefleXion Medical, Inc.
    Inventors: Samuel Mazin, Akshay Nanduri
  • Patent number: 10143436
    Abstract: The particle therapy system includes a particle beam generator for generating a particle beam; an irradiation nozzle arranged in a treatment room and irradiating a target with the particle beam; a particle beam transport system communicating the particle beam generator with the irradiation nozzle; an X-ray imaging device arranged in the treatment room and imaging the position of the target through irradiation with X-rays; a dosimeter arranged at a position passed by the particle beam in the irradiation nozzle; and a control apparatus performing control to exclude the measurement result of the X-rays from the measurement result obtained using the dosimeter when the X-rays are emitted during treatment.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: December 4, 2018
    Assignee: Hitachi, Ltd.
    Inventors: Arao Nishimura, Koji Matsuda, Ryosuke Shinagawa, Taisuke Takayanagi, Masahiro Tadokoro, Takao Kidani, Hideaki Nihongi, Kikuo Umegaki, Taeko Matsuura
  • Patent number: 10143858
    Abstract: Disclosed is a computer-implemented medical data processing method for determining a dose distribution for use in a medical procedure involving irradiation of an anatomical structure of a patient's body with ionizing radiation. A processor acquires medical image data describing a medical image of the anatomical structure. The processor acquires dose distribution data describing an irradiation dose distribution spatially defined in the reference system of the medical image of the anatomical structure. Prioritization data is determined that describes, for each image unit of the medical image describing non-target tissue, a priority of that image unit for consideration during an optimization of the irradiation dose distribution described by the dose distribution data.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: December 4, 2018
    Assignee: Brainlab AG
    Inventors: Stefan Schell, Claus Promberger, Robert Grummt, Andreas Schaetti
  • Patent number: 10092774
    Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: October 9, 2018
    Assignees: Varian Medical Systems International, AG, Varian Medical Systems, Inc.
    Inventors: Reynald Vanderstraten, Eric Abel, Christel Smith, Anthony Magliari, Timo Koponen, Stanley Mansfield, Charles Adelsheim
  • Patent number: 10092346
    Abstract: Systems and methods that enable delivery of radiofrequency energy and cryotherapy applications to adipose tissue for reduction and contouring of body fat are described herein. Aspects of the disclosure are directed to methods for reducing surface irregularities in a surface of a subject's skin resulting from an uneven distribution of adipose tissue in the subcutaneous layer. The method can include delivering capacitively coupled or conductively coupled radiofrequency energy to a target region of the subject at a frequency which selectively heats fibrous septae in a subcutaneous layer of the target region to a maximum temperature less than a fibrous septae denaturation temperature. Furthermore, the method can include removing heat such that lipid-rich lobules in the subcutaneous layer are affected while non-lipid-rich cells and lipid-rich regions adjacent to the fibrous septae are not substantially affected.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: October 9, 2018
    Assignee: Zeltiq Aesthetics, Inc.
    Inventor: Mitchell E. Levinson
  • Patent number: 10092773
    Abstract: A subject target tissue specific template device (300) that includes a block of material (302) and a plurality of apertures (310) in the material. An aperture of the plurality of apertures is located in the block of material at a location that corresponds to an area of interest identified in an image of an anatomical region of interest of a subject and transferred to an image of block of material with no aperture, which is geometrically aligned with the image of the anatomical region of interest of the subject. A method includes aligning, with a computing system, an image of anatomical tissue of interest with an image of a grid, marking at least one area of interest of tissue of interest within the image of tissue of interest, transferring the marking to the image of the grid, and saving the image of a grid with the marking as a file in an electronic format.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: October 9, 2018
    Assignee: Analogic Corporation
    Inventors: David Leong, John P. O'Connor
  • Patent number: 10092589
    Abstract: In order to provide a novel cancer treatment method using a FTD?TPI combination drug that exhibits markedly excellent anti-tumor effects with fewer side effects, the present invention provides an anti-tumor agent characterized in that the FTD?TPI combination drug and an anti-tumor platinum complex are administered in combination.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: October 9, 2018
    Assignee: Taiho Pharmaceutical Company Limited
    Inventor: Hiroyuki Okabe
  • Patent number: 10086214
    Abstract: The invention relates to a method and apparatus for generation of two-dimensional images using X-rays, proton tomography, and/or carbon ion tomography to form one or more independent and/or integrated three-dimensional images of a tumor, where the proton and carbon cation beams use common elements of a tumor treatment beam, such as an injector, accelerator, and/or beam transport device. A previously collected image of the tumor and/or a current/real-time image control slice is used in control of a multi-axes and/or a multi-field tumor irradiation system for cancer irradiation.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: October 2, 2018
    Inventor: Vladimir Balakin
  • Patent number: 10070831
    Abstract: The invention comprises a positively charged particle based cancer therapy system integrated with at least one off-axis imaging system, where elements of the off-axis imaging system and the cancer therapy system are co-positioned/co-rotated with a gantry. The imaging apparatus optionally functions with a tomography system using the positively charged particles of the cancer therapy system for enhanced patient/tumor imaging at and/or prior to a time of treatment.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: September 11, 2018
    Inventors: James P. Bennett, Stephen L. Spotts, W. Davis Lee, Susan L. Michaud
  • Patent number: 10058715
    Abstract: The invention relates to a method for quality assurance of a radiation field (30) emitted by a radiation therapy apparatus (10), comprising the steps of: (i) providing an ionization chamber (40) detector as reference detector for measuring the dose of the radiation field (30) at the exit of the radiation head (20), said ionization chamber (40) having a size and being positioned for being traversed by said radiation beam (30), said ionization chamber (40) having an attenuation equivalent to less than 1 mm Al; (ii) providing one or more field detectors (50); moving the field detector (50) across the radiation field (30) and measuring simultaneously the dose from the field detector (50) and from the ionization chamber (40); (iii) computing the ratio of the dose from the field detector (50) to the dose of the ionization chamber (40). The invention also relates to a device for performing the method.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: August 28, 2018
    Assignee: Ion Beam Applications S.A.
    Inventors: Salih Arican, Juan Carlos Celi
  • Patent number: 10058994
    Abstract: An exoskeleton includes a first link that pivots in a transverse plane about a first vertical axis and a second link that pivots in a transverse plane about a second vertical axis. The second link is coupled to the first link. An arm support assembly is coupled to the second link and pivots about a horizontal axis. The arm support assembly includes a spring that generates an assistive torque that counteracts gravity. The arm support assembly provides the assistive torque to an arm of a wearer to support the arm of the wearer. The arm support assembly further includes a cam profile and a cam follower. Contact between the spring, cam follower and cam profile determines an amount of the assistive force provided by the arm support assembly. A cuff is coupled to the arm support assembly and the arm of the wearer.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: August 28, 2018
    Assignee: Ekso Bionics, Inc.
    Inventors: Russ Angold, James Lubin, Mario Solano, Chris Paretich, Tom Mastaler
  • Patent number: 10016623
    Abstract: The present disclosure relates to a particle therapy system for irradiating a target with a scanning beam technique. In one implementation, the system includes an irradiation planning device with a planning algorithm configured to associate a particle beam energy E(i) to each spot of the irradiation plan and organize the spots in a sequence of spots according to energy. The system may further include a control system configured for controlling in parallel, from spot to spot, a variation of an output energy of a beam generator, a variation of a magnetic field of one or more electromagnets of a beam transport system and a variation of a magnetic field of the scanning magnet.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: July 10, 2018
    Assignee: Ion Beam Applications S.A.
    Inventors: Yves Claereboudt, Damien Prieels
  • Patent number: 10010720
    Abstract: Apparatus and methods for therapy delivery are disclosed. In one embodiment, a therapy delivery system includes a plurality of movable components including a radiation therapy nozzle and a patient pod for holding a patient, a patient registration module for determining a desired position of at least one of the plurality of movable components, and a motion control module for coordinating the movement of the least one of the plurality of movable components from a current position to the desired position. The motion control module includes a path planning module for simulating at least one projected trajectory of movement of the least one of the plurality of moveable components from the current position to the desired position.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: July 3, 2018
    Assignee: VISION RT LIMITED
    Inventors: Chieh C. Cheng, David A. Lesyna, Michael F. Moyers
  • Patent number: 10004481
    Abstract: Some embodiments provide a method of providing ultrasound energy having a stable power output. The method can comprise providing ultrasound energy from a ultrasound transducer; determining a power level threshold of the ultrasound energy; monitoring a power level of the ultrasound energy over time of the ultrasound energy; communicating a power level to a controller; adjusting the frequency of the ultrasound energy upon a change in the power level; and maintaining the power level threshold of the ultrasound energy.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: June 26, 2018
    Assignee: GUIDED THERAPY SYSTEMS LLC
    Inventors: Michael H. Slayton, Paul Jaeger
  • Patent number: 10004661
    Abstract: A system and method for the present invention utilizes a generator, in combination with a radiation unit, to direct waveform energy towards a target tissue using a predetermined protocol directed by titration-like feedback. The effect of the waveform energy on cellular structures of the target tissue is periodically monitored, and the predetermined protocol is halted when the cellular structure has been transformed into a desired phenotype.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: June 26, 2018
    Assignee: STRATHSPEY CROWN HOLDINGS, LLC
    Inventors: Robert Edward Grant, Todd Mirzai, Matthew T. Case
  • Patent number: 9999603
    Abstract: The present invention relates to compositions and methods for treatment of proliferative disease. In specific aspects, the present invention relates to compositions including (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine (leelamine) and arachidonyl trifluoromethyl ketone (ATK) in combination; methods for treatment of cancer including administration of leelamine and ATK in a subject in need thereof; and particularly methods for treatment of skin cancer including administration of leelamine and ATK in a subject in need thereof.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 19, 2018
    Assignee: The Penn State Research Foundation
    Inventors: Gavin P. Robertson, Omer F. Kuzu
  • Patent number: 9993663
    Abstract: There is presented a method 100 and apparatus 200 to measure the surface of the patient (thorax and abdominal regions), e.g., during therapy delivery and (if necessary) while imaging. Together with biomechanical considerations the position of internal structures of the patient, such as an organ, and optionally a tumor in an organ, is inferred from the measured patient surface. In case the patient breaths and thus the organ and/or tumor moves, the position may be determined, which may be advantageous during, e.g., radiation therapy, since it enables that whenever the tumor is at the right position according to the radiation therapy plan, the radiation is switched on. In a specific embodiment, a finite element model is employed.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: June 12, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jörg Sabczynski, Bharat Ramachandran, Ehsan Dehghan Marvast, Weihua Zhou
  • Patent number: 9993661
    Abstract: A system and method for light stimulation within a medium. Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: June 12, 2018
    Assignee: IMMUNOLIGHT, LLC.
    Inventors: Frederic A. Bourke, Jr., Harold Walder
  • Patent number: 9998237
    Abstract: Embodiments include an implant and a method of operating the implant. The implant includes a receiver that receives first ultrasound signals emitted by an external transmitting unit of a further apparatus. The receiver includes a piezoelement, which is excited by the first ultrasound signals at a first resonance frequency (f1) and therefrom converts the mechanical energy transferred with the first ultrasound signals into electrical energy. In embodiments of the invention, the piezoelement is additionally excited at a second resonance frequency (f2), which differs from the first resonance frequency (f1), and at the second resonance frequency (f2) operates as a transmitter to transmit second ultrasound signals.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: June 12, 2018
    Assignee: Biotronik SE & Co. KG
    Inventor: Christian Moss
  • Patent number: 9993307
    Abstract: A robotic surgery system includes a robot and an instrument assembly. The instrument assembly includes a drive unit with at least one rotary drive having an electric motor and a drive shaft that has a coupling part for coupling to a drive shaft of the instrument; an instrument including an instrument shaft and a drive shaft that has a coupling part for coupling to a drive shaft of the drive unit; and an instrument interface including a sheath that encompasses the drive unit. In order to detachably couple an instrument module to an instrument part of a surgical instrument, an electromagnet in a magnet assembly of the instrument module is activated or deactivated, a permanent magnet of said magnet assembly is moved into a locking position and/or an angular position of a coupled counter element assembly of the instrument part is detected by an angle sensor of the instrument module.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: June 12, 2018
    Assignee: KUKA Deutschland GmbH
    Inventors: Sebastian Lohmeier, Wolfgang Schober
  • Patent number: 9974976
    Abstract: A system for visualizing and modifying the thickness of a compensator for radiation therapy in the context of a desired target and dose coverage thereof includes planar slice image generation module, a visualization unit and an adjustment module. The planar slice image generation module generates a series of planar slice images from a patient image data set disposed with one axis parallel to a radiation beam and one axis perpendicular to the radiation beam. The visualization unit graphically depicts a compensator thickness profile, a target of interest, and/or a dose representation on at least one of the series of planar slice images all in the same plane lying in a beam's longitudinal direction. The adjustment module receives user input of an adjustment of at least one compensator thickness value via a manipulation of the graphical depiction thereof.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: May 22, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Sean Frigo
  • Patent number: 9962556
    Abstract: A method for delivering therapeutic light ion radiation to a target volume of a subject, wherein the target volume is located at a predetermined depth from the skin, includes irradiating a surface of the skin with an array of light ion minibeams comprising parallel, spatially distinct minibeams at the surface in an amount and spatially arranged and sized to maintain a tissue-sparing effect from the skin to a proximal side of the target volume, and to merge into a solid beam at a proximal side of the target volume. A gap between the parallel, spatially distinct minibeams at the surface and a species of light ions forming the minibeams are selected such that the array merges into a solid beam at a predetermined beam energy, and across all energies for Bragg-peak spreading, at a proximal side of the target volume.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: May 8, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: F. Avraham Dilmanian, Sunil Krishnan, John Eley
  • Patent number: 9949723
    Abstract: The medical imaging apparatus includes a storage unit configured to store a patient adaptive object model in which a statistical object model related to transformation of an object caused by a periodic movement is applied to characteristics of the object of a target patient; an image obtainer configured to acquire a first image of the target patient; and an image fuser configured to transform a second image of the target patient based on differences between a shape of the object extracted from the patient adaptive object model and a shape of the object displayed on the first image.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: April 24, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Young Taek Oh, Jung Woo Chang, Ja Yeon Jeong, Won-Chul Bang
  • Patent number: 9878177
    Abstract: The present disclosure relates to systems, methods, and computer-readable storage media for segmenting medical image. Embodiments of the present disclosure may locate and track a moving, three-dimensional (3D) target in a patient undergoing image-guided radiation therapy. For example, an adaptive filter model for a region of interest in the patient may be received, wherein the adaptive filter model is based on the target to be tracked. An image acquisition device may obtain a two-dimensional (2D) slice of a region of interest in the patient. A processor may then apply the adaptive filter model to the 2D slice, wherein the adaptive filter model includes an offset value. The processor may also determine a location of the target in the 2D slice based on the adaptive filter model. The processor may also estimate a potential location of the target based on the offset value. The processor may then repeat one or more of the above steps to track the moving target during image-guided radiation therapy of the patient.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: January 30, 2018
    Assignee: Elekta AB (Publ)
    Inventors: Xiao Han, Yan Zhou
  • Patent number: 9873002
    Abstract: A method is provided for evaluating a procedure for determining an aggregate radiotherapy dose received in the course of a radiotherapy treatment. The method includes: defining a deformable model of at least one organ to be treated and of at least one neighboring organ, generating a series of simulated images, interpretable by the procedure to be evaluated, with aid of the model; comparing the aggregate dose calculated by the procedure to be evaluated, applied to at least one of the simulated images, with a reference aggregate dose, so as to deliver at least one item of information representative of the quality of the procedure, the reference aggregate dose being obtained by taking into account anatomical deformations applied to the organs, so as to determine a reference dose actually received at each treatment session by the organs, as a function of their actual shape and/or actual position during this session.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: January 23, 2018
    Assignee: UNIVERSITE DE RENNES 1
    Inventors: Renaud De Crevoisier, Pascal Haigron, Antoine Simon, Guillaume Cazoulat, Aurelien Dumenil
  • Patent number: 9861834
    Abstract: A method of radiation therapy planning and delivery is provided that includes introducing a demand metric, using a volumetric modulation arc therapy system, to select a spatially optimized and non-uniform set of station or control points to be used for intensity modulation, where the set of station or control points are uniform or non-uniform, and selecting a set of control points at different gantry angles, using the volumetric modulated arc therapy system, and using the demand metric to prioritize which station or control point receives intensity modulation, where the volumetric modulated arc therapy system is differentially boosted at selected angles by inserting additional segments to the station, where the inserted additional apertures dosimetrically boost desired regions in a planning target volume to improve planning target volume coverage in a single arc rotation while sparing sensitive structures.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: January 9, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei Xing, Ruijiang Li
  • Patent number: 9789337
    Abstract: A system includes acquisition of a first three-dimensional image of a patient volume using a magnetic resonance imaging scanner, acquisition of a second three-dimensional image of the patient volume using cone beam radiation emitted by the linear accelerator, and generation of a radiation treatment plan based on the first image and the second image.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: October 17, 2017
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventor: Ali Bani-Hashemi
  • Patent number: 9762907
    Abstract: A system and method for compressing data is disclosed. The system and method include one or more data compression algorithms with at least one data compression algorithm from among the one or more data compression algorithms utilizing an asymmetric data compression. The system and method determine a type of data having one or more parameters, attributes, or values of the data from at least a portion of a data block; select one or more data compression algorithms from among the one or more data compression algorithms based upon the determined type of data and a throughput of a communications channel; and perform data compression with the selected one or more data compression algorithms on at least the portion of the data block.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: September 12, 2017
    Assignee: Realtime Adaptive Streaming, LLC
    Inventors: James J. Fallon, Stephen J. McErlain
  • Patent number: 9737730
    Abstract: The invention designs a segmented short-arc VMAT plan, modified from the original VMAT plan, to fit the breath-hold interval. The modified VMAT of the invention has the advantages of its applicability to different planning systems for variously long arcs and its preprogrammed arc segmentation for summated dose consistency. The present invention provides a method and a system for use in administering radiation therapy to patients using a radiotherapeutic apparatus with gantry rotation, and also meets the requirements for dose planning and accurate delivery, as well as coordinates patient's breath-hold level.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: August 22, 2017
    Inventor: Jason Chia-Hsien Cheng
  • Patent number: 9700621
    Abstract: The present application relates to activable nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cells, tissues or organs. It more particularly relates to nanoparticles which can generate a significantly efficient therapeutic effect, when exposed to ionizing radiations. The inventive nanoparticle is a metallic nanoparticle having, as the largest size, a size comprised between about 80 and 105 nm, the metal having preferably an atomic number (Z) of at least 25. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: July 11, 2017
    Assignee: NANOBIOTIX
    Inventors: Laurent Levy, Agnes Pottier, Laurence Poul, Laurence Maggiorella
  • Patent number: 9700044
    Abstract: Symmetrical marinopyrrole derivatives are disclosed herein, as is a synthetic route for producing these compounds. Also disclosed are methods of using symmetrical marinopyrrole derivatives to treat bacterial pathogens, like MRSE, MSSA and MRSA.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: July 11, 2017
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., Chongqing Zein Pharmaceutical Co., Ltd.
    Inventors: Yong Qin, Chunwei Cheng, Hao Song, Rongshi Li, Yan Liu
  • Patent number: 9671508
    Abstract: The disclosed device for detecting the position and dose distribution of a therapeutic proton beam emitted in a pencil beam scanning mode comprises: a proton beam progressing position detection unit comprising a plurality of first optical fibers arranged along the first direction and a plurality of second optical fibers arranged along the second direction which is different from the first direction; and a proton beam dose distribution detection unit comprising a plurality of optical wavelength converter, each of which comprises an optical wavelength conversion disk and an optical wavelength-converting optical fibers arranged along the outer circumference of the optical wavelength conversion disk.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: June 6, 2017
    Assignee: National Cancer Center
    Inventors: Dong Ho Shin, Me Young Kim, Joo Young Kim, Jae Man Son, Se Byeong Lee, Young Kyung Lim, Ui Jung Hwang
  • Patent number: 9636516
    Abstract: Devices and methods for tissue treatment produce a shock wave therapy and electromagnetic field therapy. The shock wave therapy provides stimulation of the blood circulation and stimulates the treated cells. The electromagnetic field enables thermal treatment of tissue. Combination of both therapies improves soft tissue treatment, mainly connective tissue in the skin area and fat reduction.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: May 2, 2017
    Assignee: BTL Holdings Limited
    Inventor: Tomá{hacek over (s)} Schwarz
  • Patent number: 9607385
    Abstract: A method and device for adjusting a monitored region in a tracking scan, comprising: selecting a best match of a positioned image from tracked image(s) as a monitored layer image so as to reduce position deviation of the monitored layer image with respect to the positioned image in a direction perpendicular to a plane on which the positioned image is located; and adjusting a position of a second monitored region on the monitored layer image according to a position of a corresponding first monitored region selected from the positioned image so as to reduce position deviation of the second monitored region with respect to the first monitored region in a plane parallel to the plane on which the positioned image is located.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: March 28, 2017
    Assignee: NEUSOFT MEDICAL SYSTEMS CO., LTD.
    Inventors: Shuangxue Li, Shanshan Lou
  • Patent number: 9604074
    Abstract: Radiation therapy devices, systems and methods are in general sheet-like form, are characterized by flexibility, and include at least one spacer that can be a balloon or bubble that assists in placement of radio therapeutic members at desired treatment locations along or around a limb, within an existing body cavity, or at a site that was formed under a patient's skin for treatment purposes. Sarcoma treatment is particularly conducive to treatment by these devices, systems and methods. One or more detectors, such as microdiodes, are accommodated when desired on the device, and a hyperthermia tube or the like is also includable that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 28, 2017
    Inventor: Mark A. D'Andrea