Radioactive Substance Applied To Body For Therapy Patents (Class 600/1)
  • Patent number: 10799722
    Abstract: A Boron neutron cancer treatment system has a secondary moderator having a central treatment chamber, and several generators, each comprising a pre-moderator block, an acceleration chamber, a vacuum pump engaging the acceleration chamber at a right angle, a plasma ion chamber opening into the acceleration chamber, a gas source providing deuterium gas to the plasma ion chamber, a microwave energy source ionizing the gas in the plasma ion chamber, a cylindrical primary isolation well extending into the pre-moderator block, a secondary isolation well surrounding the primary isolation well, and a water-cooled titanium target disk at a lower extremity of the isolation well. The neutron generators are positioned around the secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber, and with the angled sides of the neutron generators fully adjacent.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 13, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10751552
    Abstract: A tumor tracking control device (41) performs windowing process on a captured image A (61) and a captured image B (62), measures a position of a marker (29) using the captured image A (61) and the captured image B (62) after performing the windowing process, and generates a signal capable of controlling irradiation with radiation based on the position of the marker (29). Accordingly, it is possible to provide a tumor tracking apparatus and an irradiation system which are capable of tracking an object to be tracked without erroneous detection, even in a case where a structure similar to the object to be tracked is in the vicinity of the object to be tracked, in tumor tracking.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: August 25, 2020
    Assignees: HITACHI, LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Takahiro Yamada, Toru Umekawa, Yusuke Fujii, Naoki Miyamoto, Kikuo Umegaki
  • Patent number: 10747412
    Abstract: In a method and apparatus for adjusting a table position in a medical data acquisition scanner, image data relating to a body region are generated by operation of the medical data acquisition scanner by running a scanning protocol. The scanning protocol is intended to be used independently of the body region that is mapped. An iso-mode, in which a relative position of the body region relative to the isocenter of the medical data acquisition scanner can be set via the table position in accordance with an optimization criterion, and on a ref-mode, in which the table position is set at a predetermined reference position, are provided.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: August 18, 2020
    Assignee: Siemens Aktiengesellschaft
    Inventors: Miriam Keil, Christof Krellmann, Peter Schmitt
  • Patent number: 10744344
    Abstract: The invention relates to system and a method for adapting a radiotherapy treatment plan for treating a target structure within a target region of a patient body, where a planning unit (7) adapts the treatment plan on the basis of a set of influence parameters quantifying an influence of the radiation on the target region per unity intensity emission in accordance with an anatomical configuration of the target region. In a storage (8), a plurality of sets of influence parameters is stored, each set being associated with an image of the body region representing a particular anatomical configuration of the target region and the planning unit (7) is configured to select the set of influence parameters from the stored sets on the basis of a comparison between a captured image of the body region and at least one of the images associated with the sets of influence parameters.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: August 18, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Alfonso Agatino Isola, Pedro Jorge Da Silva Rodrigues, Davide Fontanarosa
  • Patent number: 10737121
    Abstract: A neutron generator has a pre-moderator block of moderating material, an acceleration chamber, a vacuum pump evacuating the acceleration chamber to a moderately high vacuum, a plasma ion chamber opening into the acceleration chamber through an ion extraction iris, a gas source providing deuterium gas to the plasma ion chamber, a microwave energy source ionizing the gas in the plasma ion chamber, a primary and a secondary isolation well extending into the pre-moderator block, a water-cooled titanium target disk positioned at a lower extremity of the primary isolation well, the target disk biased to a substantial negative DC voltage, and electrically grounded metal cladding covering surfaces of the pre-moderator block. Ions extracted through the ion extraction iris are accelerated to bombard the titanium target producing energetic neutrons that pass through and are moderated by the pre-moderator block.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: August 11, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10737117
    Abstract: A medical apparatus according to an embodiment includes an acquirer, an identifier, an output controller, a display controller, and an input operation acquirer. The acquirer acquires a fluoroscopic image of a object from an imager which performs imaging by irradiating the object with an electromagnetic wave to generate the fluoroscopic image. The identifier identifies a target position of the object in the fluoroscopic image. The output controller outputs an irradiation permission signal to a therapeutic device which irradiates the object with a therapeutic beam when the target position identified by the identifier is settled within an irradiation permission range. The display controller causes a display to display an interface image for receiving an instruction to start each of a preparation stage of a therapy and an irradiation stage of the therapeutic beam. The input operation acquirer acquires details of an input operation performed by a user in the interface image.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: August 11, 2020
    Assignee: Toshiba Energy Systems & Solutions Corporation
    Inventors: Shinichiro Mori, Keiko Okaya, Ryusuke Hirai, Koki Yanagawa, Fumi Maruyama, Yasushi Iseki
  • Patent number: 10722734
    Abstract: The radiation detection device includes a plurality of radiation detectors arranged in a row and is inserted into the body of patient subjected to the X-ray therapy. An X-ray detection signal (photon) is output from each of the radiation detectors that detects the X-ray applied to the patient. The dose rate measurement device separately connected to each of the radiation detectors obtains the dos rate at the position of each radiation detector based on the signals. The irradiation direction determination device determines whether the row of radiation detectors matches the irradiation direction of the X-ray using the dos rate obtained by each of the dose rate measurement devices. When the row of radiation detectors matches the irradiation direction, the energy distribution analysis device obtains an energy distribution using the dose rate at the positions of the radiation detectors by applying, for example, an inverse problem analysis called an unfolding method.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: July 28, 2020
    Assignee: HITACHI, LTD.
    Inventors: Yasushi Nagumo, Takahiro Tadokoro, Yuichiro Ueno, Katsunori Ueno, Kouichi Okada, Shuichi Hatakeyama
  • Patent number: 10723016
    Abstract: A wearable hand robot of the present invention is a wearable hand robot which is mounted on a user's fingers and can bend the user's fingers by means of an external force transmitted through a wire, and comprises: at least one first wire which is disposed to extend toward the tip of a finger and then change the extension direction toward the base of the finger; a finger cap which is configured to be fit on the tip of the finger and includes a first wire tube which is disposed at the end of the finger so that the first wire passes therethrough and is U-shaped; a finger member comprising two second wire tubes, at least one finger strap and at least one bending unit; and a support member which is mounted on the hand adjacent to the user's wrist and through which the first wire extending from the finger member passes. The two second wire tubes are configured to extend in the extension direction of the finger segment and are disposed on the respective sides of the finger, and the first wire passes therethrough.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: July 28, 2020
    Assignee: NATIONAL REHABILITATION CENTER
    Inventors: Kyu-Jin Cho, Hoyoung Ban, Brian Byunghyun Kang, Hyunki In, Haemin Lee, Jinwon Chung, Ki Hun Cho
  • Patent number: 10697023
    Abstract: An example method of treating a subject having a tumor is described herein. The method can include determining a radiosensitivity index of the tumor, deriving a subject-specific variable based on the radiosensitivity index, and obtaining a genomic adjusted radiation dose effect value for the tumor. The radiosensitivity index can be assigned from expression levels of signature genes of a cell of the tumor. Additionally, the genomic adjusted radiation dose effect value can be predictive of tumor recurrence in the subject after treatment. The method can also include determining a radiation dose based on the subject-specific variable and the genomic adjusted radiation dose effect value.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: June 30, 2020
    Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    Inventors: Jacob Scott, Javier F. Torres-Roca
  • Patent number: 10688203
    Abstract: In one aspect, radioactive nanoparticles are described herein. In some embodiments, a radioactive nanoparticle described herein comprises a metal nanoparticle core, an outer metal shell disposed over the metal nanoparticle core, and a metallic radioisotope disposed within the metal nanoparticle core or within the outer metal shell. In some cases, the radioactive nanoparticle has a size of about 30-500 nm in three dimensions. In addition, in some embodiments, the radioactive nanoparticle further comprises an inner metal shell disposed between the metal nanoparticle core and the outer metal shell. The metal nanoparticle core, outer metal shell, and inner metal shell of the radioactive nanoparticle can have various metallic compositions.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: June 23, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Xiankai Sun, Yaowu Hao, Sina Moeendarbari
  • Patent number: 10685810
    Abstract: An apparatus for generating plasma, including a quadrupole antenna having a center region and an outer region and configured to be disposed over a dielectric window of a plasma chamber. The quadrupole antenna including a first coil defining a first SDA and a second coil defining a second SDA, the first coil being in a nested arrangement within the second coil. The nested arrangement places a turn of the first coil to be adjacent to a corresponding turn of the second coil as the first and second coils spiral from the center region to the outer region of the quadrupole antenna. Adjacent turns of each of the first and second coils are horizontally separated from one another by a distance when disposed over the dielectric window.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: June 16, 2020
    Assignee: Lam Research Corporation
    Inventors: Hema Swaroop Mopidevi, Lee Chen, Thomas W. Anderson
  • Patent number: 10668153
    Abstract: A boron neutron capture therapy system has a neutron beam irradiation device, a patient restraint/placement portion, a three-dimensional diagnostic device, an irradiation table, a position adjustment mechanism, and a control unit. The boron neutron capture therapy system performs position determination with a sufficient degree of accuracy at the time of the boron neutron capture therapy. Further, the control unit, using the movement of the irradiation table, performs collision avoidance processing that changes the movement of the irradiation table before the patient restrained on the patient restraint/placement portion receives injury by colliding with the irradiation port, and thus, collision between the patient and the irradiation port can be avoided.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: June 2, 2020
    Assignees: Fujidenolo Co. Ltd., Cancer Intelligence Care Systems, Inc.
    Inventors: Tsuyako Takeyoshi, Masaru Nakamura, Yoshio Imahori, Hideki Miyazaki, Toshitaka Fujioka, Shinsuke Kato
  • Patent number: 10661097
    Abstract: Computer-implemented methods and systems can be used to facilitate generation of VMAT treatment plans for providing radiation therapy to patients. Starting from a seed plan, a library of alternative plans, each with an associated outcome for a set of treatment objectives, can be generated via a set of parallel optimization operations performed on the seed plan. A graphical user interface is provided, via which the user can navigate within a treatment space defined by the alternative plans to identify a satisfactory outcome. Based on the satisfactory outcome and a candidate plan selected from the alternative plans, a deliverable VMAT treatment plan can be generated using another optimization operation.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: May 26, 2020
    Assignees: Varian Medical Systems, Inc., Varian Medical Systems International AG
    Inventors: Tuomas Tallinen, Stephen K. Thompson, Joona Hartman, Perttu Niemelä
  • Patent number: 10666301
    Abstract: This multifrequency device (10) is configured to be connected via at least two conductors (121, 122) to an electricity supply grid (11). This device comprises: at least one radiofrequency module (13) comprising at least one first and one second input/output port (131, 132), which ports are able to emit and/or receive radiofrequency signals at two different frequencies; and at least two matching circuits (14, 15) that are configured to block the propagation of radiofrequency signals propagating over the conductors, each matching circuit comprising a plurality of terminals. One terminal (141, 151) of each matching circuit is connected to the first conductor or to the second conductor. One terminal (142, 151) of each matching circuit is connected to the first input/output port or to the second input/output port of the radiofrequency module.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: May 26, 2020
    Assignee: SOMFY ACTIVITES SA
    Inventors: Michel Ramus, Serge Robin
  • Patent number: 10653892
    Abstract: An example device for trimming a particle beam includes: structures made of material that blocks passage of the particle beam, with the structures being configurable to define an edge that is movable into a path of the particle beam; and linear motors that are controllable to configure the structures to define the edge.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: May 19, 2020
    Assignee: Mevion Medical Systems, Inc.
    Inventors: Mark R. Jones, James Cooley
  • Patent number: 10653789
    Abstract: Pharmaceutical compositions comprising two or more therapeutically active agents, such as two or more anticancer agents, conjugated to one or more biocompatible polymers, wherein the molar ratio of the agents and/or schedules of delivery provide a synergistic therapeutic effect, are described. Methods of making and using the pharmaceutical compositions are further described. In one embodiment, the pharmaceutical compositions contain topoisomerase I and topoisomerase II inhibitors conjugated to the same or different biocompatible polymers. The two or more anticancer agents are covalently coupled to the polymer(s), and thereby can be delivered to a tumor at a molar ratio which provides a synergistic effect. Optionally, the agents are coupled indirectly to the polymer(s) via a linker.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: May 19, 2020
    Assignee: The Regents of the University of California
    Inventors: Kathryn M. Camacho, Stefano Menegatti, Sunny Kumar, Douglas Vogus, Samir Mitragotri
  • Patent number: 10653894
    Abstract: Embodiments disclose methods and apparatus for managing the provision of radiotherapy treatment. The method includes storing a database of calibration settings for a plurality of components of a first radiotherapy system. The calibration settings may be used by the first radiotherapy system to translate treatment plans into instructions for the plurality of components to carry out. The method further includes deriving from the database allowable ranges of values for the calibration settings. The method also includes receiving from a second radiotherapy system calibration settings for the second radiotherapy system prior to implementation of a treatment plan, comparing the calibration settings for the second radiotherapy system with the derived allowable ranges of values, and generating an alert signal when a subset of the calibration settings for the second radiotherapy system falls outside the allowable range of values.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: May 19, 2020
    Assignee: ELEKTA LIMITED
    Inventor: Timothy Prosser
  • Patent number: 10610700
    Abstract: A method of evaluating the robustness of a radiotherapy treatment plan for ion based radiotherapy, comprises the steps of: obtaining information related to the incident energy of ions that will stop in each voxel of the treatment volume; calculating a quantity value representative of the incident energy of these ions; and using the quantity values calculated for the first and second portion as a measure of the quality of the radiotherapy treatment plan, in particular its robustness. The information may include the mean incident energy for all ions, and/or an indication of the distribution of the energy values for all the ions.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: April 7, 2020
    Assignee: RaySearch Laboratories AB
    Inventor: Erik Traneus
  • Patent number: 10607738
    Abstract: Various embodiments are described herein for a system and a method for treatment planning for providing ablative therapy to a patient. The treatment planning may involve segmenting images of the patient to define areas to receive treatment, defining trial parameters, simulating treatment of ablative therapy to the patient according to the trial parameters; analyzing a thermal dose distribution resulting from the simulated treatment to determine treatment effectiveness; determining when the treatment effectiveness meets a treatment effectiveness criteria; and providing an indication of the trial parameters when the treatment effectiveness meets the treatment effectiveness criteria.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: March 31, 2020
    Assignees: University Health Network, Sunnybrook Research Institute
    Inventors: Sean Davidson, Michael D. Sherar, Kieran Murphy, Claire McCann, Robert Weersink
  • Patent number: 10603510
    Abstract: A process for treating highly localized carcinoma cells that provides precise positioning of a therapeutic source of highly ionizing but weakly penetrating radiation, which can be shaped so that it irradiates essentially only the volume of the tumor. The intensity and duration of the radiation produced by the source can be activated and deactivated by controlling the neutron flux generated by an array of electrically controlled neutron generators positioned outside the body being treated. The energy of the neutrons that interact with the source element can be adjusted to optimize the reaction rate of the ionized radiation production by utilizing neutron moderating material between the neutron generator array and the body. The source device may be left in place and reactivated as needed to ensure the tumor is eradicated without exposing the patient to any additional radiation between treatments. The source device may be removed once treatment is completed.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: March 31, 2020
    Assignee: Westinghouse Electric Company LLC
    Inventors: John H. Nelson, Michael D. Heibel
  • Patent number: 10603516
    Abstract: A method for neutron-capture therapy has steps for emitting fast neutrons from a plurality of target structures by ion bombardment from ion sources DC biased to the target structures, the target structures positioned around a moderator structure composed primarily of moderator material, the moderator structure having a length, an outer periphery, an outer surface, an inside volume, and an inner surface, the inside volume defining a treatment zone, reflecting fast neutrons that are emitted from the target structures in a direction away from the moderator structure, into the moderator structure, by a reflector structure surrounding the moderator structure, the target structures, and the ion sources, moderating fast neutrons passing inward through the moderator structure toward the treatment zone to epithermal energy level, and creating a density of epithermal neutrons in the treatment zone, from neutrons entering the treatment zone across the inner surface of the moderator structure.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: March 31, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Richard Harris Pantell, Charles Kevin Gary, Melvin Arthur Piestrup
  • Patent number: 10583313
    Abstract: The present disclosure relates to a new scan technique for particle radiation therapy that may be used for cancer treatment. One embodiment relates to a method of mitigating interplay effect in particle radiation therapy in a moving target including a period of movement, where the particle radiation therapy defines a planned dose in each spot of each layer of the moving target. The method comprising dividing the planned dose in each spot into a number of spot repaintings; and generating a scan pattern for each layer by defining a beam-on time at each spot for each spot repainting, and calculating a wait time between consecutive beam-on times to distribute the spot repaintings for each spot of a respective layer are distributed over a duration of an integer number of periods of movement.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: March 10, 2020
    Assignees: Varian Medical Systems Particle Therapy GmbH, University of Maryland, Baltimore
    Inventors: Per Rugaard Poulsen, John Eley, Ulrich Langner, Katja Langen
  • Patent number: 10576302
    Abstract: In a method and magnetic resonance (MR) apparatus for monitoring a radiation therapy of a patient, first MR image data are acquired with a quantitative magnetic resonance method before an irradiation of a target area of the patient, and second MR image data are acquired with the quantitative magnetic resonance method after the irradiation of the target area of the patient. The first MR image data and the second MR image data are compared, and output information is generated on the basis of a result of the comparison.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: March 3, 2020
    Assignee: Siemens Aktiengesellschaft
    Inventors: David Grodzki, Annemarie Hausotte, Bjoern Heismann, Arne Hengerer, Mark-Aleksi Keller-Reichenbecher, Sebastian Schmidt
  • Patent number: 10569104
    Abstract: The present disclosure provides a system and method for method for quantifying radioactivity production during a proton treatment of a patient. In some aspects, a method includes administering, using a proton delivery system, a proton treatment using at least one therapeutic proton beam generating positron emitting radionuclides within a region of interest (ROI) of a patient, and acquiring, using an emission tomography system, emission tomography data indicative of an activity of the positron emitting radionuclides in the ROI. The method also includes quantifying, based on a kinetic model, a radioactivity production rate of at least one positron emitting radionuclide using the emission tomography data. The method further includes generating at least one map indicative of the radioactivity production rate of the at least one positron emitting radionuclide.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: February 25, 2020
    Assignee: The General Hospital Corporation
    Inventors: Georges El Fakhri, Nathaniel Alpert, Xuping Zhu, Kira Grogg
  • Patent number: 10569413
    Abstract: An exoskeleton includes a first link that pivots in a transverse plane about a first vertical axis and a second link that pivots in a transverse plane about a second vertical axis. The second link is coupled to the first link. An arm support assembly is coupled to the second link and pivots about a horizontal axis. The arm support assembly includes a spring that generates an assistive torque that counteracts gravity. The arm support assembly provides the assistive torque to an arm of a wearer to support the arm of the wearer. The arm support assembly further includes a cam profile and a cam follower. Contact between the spring, cam follower and cam profile determines an amount of the assistive force provided by the arm support assembly. A cuff is coupled to the arm support assembly and the arm of the wearer.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: February 25, 2020
    Assignee: Ekso Bionics, Inc.
    Inventors: Russ Angold, James Lubin, Mario Solano, Chris Paretich, Tom Mastaler, Claire Cunningham, Kevin Dacey
  • Patent number: 10549116
    Abstract: In various embodiments, methods and devices are provided for generating a radiotherapy treatment plan for a subject to be implemented on a radiotherapy device. In certain embodiments the methods involve determining all feasible radiotherapy beam orientations free of collision for said radiotherapy device and said subject to provide a set of radiotherapy beam orientations; selecting from the set of all feasible radiotherapy beam orientations a subset of beams that meet treatment goals to be used in treatment of the subject to provide a selected beam set; calculating a navigation trajectory for the radiotherapy device to delivery said subset of beams to the subject where the trajectory is free of collision; and generating and writing instruction files to a tangible medium that can be executed by said radiotherapy device.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: February 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Ke Sheng, Dan Ruan, Daniel A. Low
  • Patent number: 10500418
    Abstract: An apparatus for assisting a selection of motion management technique for use with a treatment machine having an energy source, comprises: one or more input for obtaining motion trace of a target to be treated, and/or for obtaining motion data of a fiducial; and a motion management processor configured to determine motion management data based at least in part on at least a portion of the motion trace of the target and/or at least a portion of the motion data of the fiducial, wherein the motion management data indicates desirability and/or undesirability of one or more motion management option(s); wherein the motion management processor is also configured to output the motion management data for assisting the selection of the motion management technique for use with the treatment machine.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: December 10, 2019
    Assignee: Varian Medical Systems International AG
    Inventors: Reto W. Filiberti, Stefan G. Scheib, Michael Huber
  • Patent number: 10493299
    Abstract: Systems and methods can include training a deep convolutional neural network model to provide a beam model for a radiation machine, such as to deliver a radiation treatment dose to a subject. A method can include determining a range of parameter values for at least one parameter of a beam model corresponding to the radiation machine, generating a plurality of sets of beam model parameter values, wherein one or more individual sets of beam model parameter values can include a parameter value selected from the determined range of parameter values, providing a plurality of corresponding dose profiles respectively corresponding to respective individual sets beam model parameter values in the plurality of sets of beam model parameter values, and training the neural network model using the plurality of beam models and the corresponding dose profiles.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: December 3, 2019
    Assignee: Elekta, Inc.
    Inventor: Sami Hissoiny
  • Patent number: 10478591
    Abstract: A stent graft delivery device that is pre-loaded with a single guide wire for both tracking the device within a main vessel as well as for cannulating one or more branch vessels is described. The delivery device comprises a delivery catheter having a prosthesis releasably secured thereto and a nose cone extending from the proximal end of the catheter. In a delivery configuration, a secondary catheter is coaxial with the guide wire and extends through at least a portion of the prosthesis lumen and is held within a channel formed in the nose cone. In a released configuration, secondary catheter and guide wire are retracted distally out of the channel formed in the sidewall of the nose cone dilator and can be manipulated for cannulating a branch vessel.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: November 19, 2019
    Assignee: Cook Medical Technologies LLC
    Inventors: Blayne A. Roeder, Jarin Kratzberg, Erik E. Rasmussen, Derek R. Eller, Saylan Lukas
  • Patent number: 10470820
    Abstract: A laser fiber, is modified to have a tip that has a length that is predetermined to ensure that the tip remains viable throughout a given procedure type, despite the presence of burn-back. The extended tip is defined by stripping back the jacket of the laser fiber over the pre-determined length starting at the distal end of the fiber. The stripped portion of the fiber is then dip-coated with a layer of polymeric coating such as an acrylate. A visual indicator can be printed onto the extended tip to aid in the use of the extended fiber. A self-aligning stability sheath is provided to make insertion easier in certain types of endoscopes. The laser fiber with extended tip can be pre-inserted into the sheath and sold as a pre-prepared kit for ease of use and protection of the fiber.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: November 12, 2019
    Inventors: Jeffrey W. Zerfas, Alfred P. Intoccia, Jr.
  • Patent number: 10449386
    Abstract: A control circuit optimizes a brachytherapy radiation treatment plan for a patient target volume by defining a radiation-control structure that conformally surrounds the patient target volume and then automatically removes part, but not all, of the radiation-control structure to control consideration of radiation sources that are not disposed within the patient target volume. By one approach the control circuit selectively removes parts of the radiation-control structure as a function of the geometry as corresponds to placement of one or more of the radiation sources. For many application settings it serves well for the radiation-control structure to represent a radiation-avoidance area.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: October 22, 2019
    Assignee: Varian Medical Systems International AG
    Inventors: Joni Bask, Toni Taiminen
  • Patent number: 10449387
    Abstract: A mechanism to facilitate the insertion of radioactive sources/source strands into soft tissue, such as breast tissue, and a method that utilizes this mechanism with the goal of improving the reproducibility of the procedure and ensuring that the sources are reliably and consistently inserted in an exact position per a patient prescription treatment plan from patient to patient as well as improve the ease-of-use of the device and procedure are provided.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: October 22, 2019
    Assignee: BREAST MICROSEED, INC.
    Inventor: Charlie Pitman
  • Patent number: 10451610
    Abstract: Provided herein are methods for identifying and treating cancers that are resistant to PARP inhibition. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided. In some aspects. PARP inhibitor cancers are treated with a PARP inhibitor therapy in combination with a c-Met inhibitor therapy.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: October 22, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Mien-Chie Hung, Yi Du
  • Patent number: 10441815
    Abstract: A neutron capture therapy system includes a neutron ray generating unit, an irradiated body placing unit on which a patient (irradiated body) is placed, and a gamma ray detecting unit that detects gamma rays emitted from the patient (irradiated body). The gamma ray detecting unit includes an emission part that emits light or electrons as the gamma rays are incident thereon, an amplification part that amplifies and outputs the light or the electrons emitted from the emission part, a first neutron ray shielding part formed of a substance containing 6-lithium, and a second neutron ray shielding part formed of a light element. The first neutron ray shielding part is provided so as to cover at least a surface opposite to an adjacent surface adjacent to the amplification part, among surfaces of the emission part.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: October 15, 2019
    Assignees: SUMITOMO HEAVY INDUSTRIES, LTD., KYOTO UNIVERSITY
    Inventors: Kiyotaka Akabori, Hiroki Tanaka
  • Patent number: 10420956
    Abstract: A medicament delivery vehicle, the vehicle comprising a reversibly deformable carrier (RDC) adapted to support the medicament on an outside surface of the carrier, an inside surface of the carrier, or homogeneously dispersed throughout the carrier. Specifically, the medicament delivery device may include a reversibly deformable carrier (RDC) adapted to support the medicament.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: September 24, 2019
    Assignee: BOSTON SCIENTIFIC CORPORATION
    Inventor: Arnold M. Herskovic
  • Patent number: 10420676
    Abstract: The present invention relates to an ophthalmic treatment device, a control method therefor and a fundus lesion treatment method, the ophthalmic treatment device comprising: a treatment beam generation unit for generating a treatment beam; a beam delivery unit for forming a path through which the treatment beam generated from the treatment beam generating unit is irradiated into a patient's fundus; and a control unit for controlling the beam delivery unit to irradiate the treatment beam into a location adjacent to the lesion area of the fundus.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: September 24, 2019
    Assignee: LUTRONIC VISION INC.
    Inventor: Jong Min Kim
  • Patent number: 10426002
    Abstract: Provided herein are high energy ion beam generator systems and methods that provide low cost, high performance, robust, consistent, uniform, low gas consumption and high current/high-moderate voltage generation of neutrons and protons. Such systems and methods find use for the commercial-scale generation of neutrons and protons for a wide variety of research, medical, security, and industrial processes.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: September 24, 2019
    Assignee: PHOENIX LLC
    Inventors: Arne Kobernik, Carl Sherven, Casey Lamers, Chris Seyfert, Evan Sengbusch, Gabriel Becerra, Jin Lee, Logan Campbell, Mark Thomas, Michael Taylor, Preston Barrows, Ross Radel, Tye Gribb
  • Patent number: 10398913
    Abstract: Provided is a control device for a radiation irradiation device including a position-related information acquisition portion that acquires position-related information related to a position of a particular site; a model generation portion that generates a model outputting the position of the particular site based on the position-related information; and a particular site position calculation portion that outputs the position of the particular site based on the position-related information acquired by the position-related information acquisition portion, by using the model generated by the model generation portion. The model generated by the model generation portion is provided with a filter regulating an amount of change in the position of the particular site output by the model.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: September 3, 2019
    Assignee: HITACHI, LTD.
    Inventor: Kunio Takahashi
  • Patent number: 10391627
    Abstract: Described herein is an arm supporting exoskeleton, comprising an arm link mechanism. The arm link mechanism comprises a proximal link, a distal link, an arm coupler, and a variable force generator. The distal link is rotatable relative to the proximal link. The arm coupler is adapted to couple an upper arm of a person to the distal link. The variable force generator comprises a first spring and a second spring, configured to create a torque between the proximal link and the distal link. In the first force mode, the variable force generator exhibits a first stiffness rate defined by the first spring that supports the upper arm of the person against gravity forces and. In the second force mode, the variable force generator exhibits a second stiffness rate defined by the first spring and the second spring that supports the upper arm of the person against the gravity forces.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: August 27, 2019
    Assignee: The Regents of the University of California
    Inventors: Logan Van Engelhoven, Homayoon Kazerooni
  • Patent number: 10376713
    Abstract: A radiation therapy planning apparatus performs dose calculation at high speed and with high accuracy for radiation therapy in a scanning irradiation method. The apparatus includes a display, an arithmetic processing apparatus, a memory, and a data server, which is connected to a particle beam irradiation apparatus. A dose calculation unit of the arithmetic processing apparatus calculates dose distribution by a simplified Monte Carlo algorithm, and corrects the dose distribution by a decreasing rate stored in a particle number decreasing rate table of the memory, and stores the corrected dose distribution in an integrated dose distribution table. By using the simplified Monte Carlo algorithm and the particle number decreasing rate that corrects the simplified Monte Carlo algorithm, the dose distribution is calculated, and thereby, it is possible to realize a radiation therapy planning apparatus that performs dose calculation at a high speed with high accuracy.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: August 13, 2019
    Assignee: Hitachi, Ltd.
    Inventors: Taisuke Takayanagi, Shusuke Hirayama, Shinichiro Fujitaka
  • Patent number: 10369381
    Abstract: The present invention provides a system and method for generating intensity modulated proton therapy plans. The method includes receiving a representation of a subject that includes information related to target and non-target volumes of interest, and computing, using the representation and a proton beam configuration that describes a number of beamlets and their respective arrangement, a dose distribution for each one of a plurality of uncertainty scenarios. The method also includes computing a robustness index for respective locations in the target volumes of interest using the dose distributions, and optimizing an objective function to determine a set of intensity weights for each beamlet in the proton beam configuration, wherein the objective function is based at least in part on deviations of the robustness indices from a prescribed robustness index. The method further includes generating a treatment plan using the determined intensity weights.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: August 6, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Wei Liu
  • Patent number: 10357572
    Abstract: Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: July 23, 2019
    Assignee: PHAROSGEN CO., LTD.
    Inventors: Sang-Yoon Kim, Youngro Byun, Seung Woo Chung
  • Patent number: 10328282
    Abstract: A system and methods are provided for generating intensity modulated proton therapy plans robust to various kinds of delivery uncertainties with the capability for treatment planners to control the balance between plan quality and robustness. The system obtains a representation of a subject and a proton beam configuration that describes a number of beamlets and their respective arrangement. The system computes an objective function, in the treatment planning system, first part of which is about dose deviations from the prescribed dose in the target volumes, second part of which is about dose deviations from the dose constraint in the non-target volumes, and computing dose volume constraints for targets using a probability to control the dose distribution in the target volumes to be between a lower threshold and an upper threshold. Based on this information, the system obtains a robust chance-constrained treatment planning model with a user-adjustable tolerance level.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: June 25, 2019
    Assignees: Mayo Foundation for Medical Education and Research, Arizona Board of Regents on behalf of Arizona State University
    Inventors: Yu An, Jianming Liang, Wei Liu
  • Patent number: 10300303
    Abstract: An image-guided therapy delivery system includes a therapy generator configured to generate a therapy beam directed to a time-varying therapy locus within a therapy recipient, an imaging input configured to receive imaging information about a time-varying target locus within the therapy recipient, and a therapy controller. The therapy generator includes a therapy output configured to direct the therapy beam according to a therapy protocol. The therapy controller is configured to automatically generate a predicted target locus using information indicative of an earlier target locus extracted from the imaging information, a cyclic motion model, and a specified latency, and automatically generate an updated therapy protocol to align the time-varying therapy locus with the predicted target locus.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 28, 2019
    Assignees: Elekta LTD., Elekta, Inc.
    Inventors: Rupert Archie Brooks, Michel Moreau, Leila Pishdad
  • Patent number: 10299740
    Abstract: Various methods and systems are provided for collision avoidance in cone-beam computed tomography (CT) systems. In one embodiment, a method for an imaging apparatus comprises calculating a likelihood of a collision between the imaging apparatus and a subject and/or its support based on a model of the subject, performing a scan of the subject responsive to the likelihood below a threshold, and not performing the scan otherwise. In this way, collisions between the patient and the imaging apparatus can be avoided.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: May 28, 2019
    Assignee: General Electric Company
    Inventors: Thomas Mc Carthy, Yves Lucien Trousset
  • Patent number: 10265406
    Abstract: The present application relates to a pharmaceutical composition comprising biocompatible nanoparticles or nanoparticles aggregates which allows the appropriate delivery of said biocompatible nanoparticles or nanoparticles aggregates to a target site in a subject in need thereof. The composition indeed allows an accumulation of the biocompatible nanoparticles or nanoparticles aggregates it comprises into the targeted tissue of the subject of at least 4 milligram (mg) nanoparticles or nanoparticles aggregates per gram (g) of targeted tissue when at least 0.1 g of the pharmaceutical composition per kilogram (kg) of body weight is injected intravenously (IV) or intraarterially (IA) into said subject.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: April 23, 2019
    Assignee: NANOBIOTIX
    Inventors: Agnes Pottier, Laurent Levy, Matthieu Germain
  • Patent number: 10254739
    Abstract: An example system includes: a magnet including one or more coils to conduct current to generate a magnetic field, with the magnetic field to affect output of radiation to a target; and one or more actuators, with an actuator among the one or more actuators being at least part of a physical coupling to the one or more coils, and with the actuator being controllable to move the one or more coils via the physical coupling based on movement of the magnet.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: April 9, 2019
    Assignee: Mevion Medical Systems, Inc.
    Inventors: Mark R. Jones, Mark Robinson, Ken Yoshiki Franzen
  • Patent number: 10238892
    Abstract: A radiotherapy treatment verification and quality assurance method may include receiving at least one set of first medical images of at least a portion of a patient. A three-dimensional model of the portion of the patient may be created based on the at least one set of first medical images. At least one dosimeter may be inserted into at least a portion of the model. The dosimeter is configured to measure exposure to radiation. The model may be irradiated in accordance with a radiotherapy treatment plan created by a treatment planning system. A readout of the model may be taken or performed to measure in three-dimensions a delivered radiation doses distribution.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: March 26, 2019
    Inventors: Evangelos T. Pappas, Thomas G. Maris
  • Patent number: 10232192
    Abstract: A planning image memory stores a volume diagnostic image. A user inputs data defining clinical objectives including organs-at-risk with a user interface device. An auto-planning module generates a candidate treatment plan. A trade-off module having a processor evaluates the treatment plan against the clinical objectives. When one or more objectives is not met, the trade-off module performs a trade-off analysis to determine an effect on other clinical objectives and generates at least one trade-off treatment plan which more closely meets the not met objectives. The candidate and at least one trade-off plan are displayed on a display device and/or analyzed by the processor and a final treatment plan is selected from the at least one trade-off or candidate treatment plan.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: March 19, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Karl Antonin Bzdusek, Sankara Hari Gopalakrishnan, Prashant Kumar
  • Patent number: 10226643
    Abstract: A control circuit utilizes patient information and treatment-platform information to optimize a radiation-treatment plan by permitting isocenters of various radiation-treatment fields as comprise parts of a same treatment plan to not be coincidental with one another to thereby yield an optimized treatment plan. The patient information can pertain to one or more physical aspects of the patient as desired. By one approach, the foregoing can comprise scattering the isocenters of the various radiation-treatment fields around a predetermined point (such as, for example, the center of the treatment volume and/or some or all of the beams). This approach can comprise causing an area of highest energy flux for a given field to be non-coincident for at least some of the radiation-treatment fields as are specified by the radiation-treatment plan.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: March 12, 2019
    Assignee: Varian Medical Systems International AG
    Inventors: Viljo Petäjä, Perttu Niemelä, Esa Kuusela