Radioactive Substance Applied To Body For Therapy Patents (Class 600/1)
  • Patent number: 11561674
    Abstract: Systems and methods include a method for providing, for presentation to a user, a graphical user interface (GUI) for defining and generating machine learning-based proxy models as surrogates for process-based reactive transport modeling (RTM). User selections of training parameters for generating training sample data are received. The training sample data is generated in response to receiving a parameter files generation indication. A training cases generation indication is received. Training sample cases are executed using the training sample data. User selections of proxy models training parameters are received. A set of parameter-specific proxy models represented by a neural network are trained. Each parameter-specific proxy model corresponds to a specific RTM parameter from a set of RTM parameters. Blind tests are performed using the set of parameter-specific proxy models. Each blind test tests a specific one of the parameter-specific proxy models.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: January 24, 2023
    Assignee: Saudi Arabian Oil Company
    Inventors: Yupeng Li, Peng Lu
  • Patent number: 11537912
    Abstract: Nominal values of parameters, and perturbations of the nominal values, that are associated with previously defined radiation treatment plans are accessed. For each treatment field of the treatment plans, a field-specific planning target volume (fsPTV) is determined based on those perturbations. At least one clinical target volume (CTV) and at least one organ-at-risk (OAR) volume are also delineated. Each OAR includes at least one sub-volume that is delineated based on spatial relationships between each OAR and the CTV and the fsPTV for each treatment field. Dose distributions for the sub-volumes are determined based on the nominal values and the perturbations. One or more dose prediction models are generated for each sub-volume. The dose prediction model(s) are trained using the dose distributions.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: December 27, 2022
    Assignee: Varian Medical Systems International AG
    Inventors: Perttu Niemela, Jari Lindberg, Tuomas Jyske, Maria Cordero Marcos, Esa Kuusela
  • Patent number: 11529531
    Abstract: A reinforcement learning agent facilitates optimization of a radiation-delivery treatment plan. The reinforcement learning agent is configured to generate a radiation-delivery treatment plan that can exceed the quality of a plan or plans employed to train the reinforcement learning agent. The reinforcement learning agent is trained to evaluate a radiation-delivery treatment plan that is output by an optimization software application, modify one or more dose-volume objective parameters of the evaluated radiation-delivery treatment plan, and then input the modified radiation-delivery treatment plan to the optimization software application for further optimization. The reinforcement learning agent adaptively adjusts the one or more dose-volume objective parameters based on an action policy learned during a reinforcement learning training process.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: December 20, 2022
    Inventors: Shahab Basiri, Esa Kuusela, Elena Czeizler, Mikko Oskari Hakala
  • Patent number: 11517397
    Abstract: A medical instrument includes an instrument shaft with exit holes near a distal end of the shaft, a tool coupled to the distal end of the shaft, and a backend. The backend may include a mechanism that manipulates a drive element that extends through the shaft and couples to the tool, a fluid inlet, and a fluid channel assembly providing fluid communication between the fluid inlet and the proximal end of the shaft. Cleaning fluid is directed into the fluid inlet, through the fluid channel assembly, and into the shaft. A chassis or other structural piece of the backend may form part of the fluid channel assembly.
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: December 6, 2022
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Bram Gilbert Antoon Lambrecht, S. Christopher Anderson, Thomas G. Cooper
  • Patent number: 11511087
    Abstract: A dual double balloon catheter includes a catheter having a proximal end portion, a central portion and a distal end portion, and a secondary treatment balloon for a catheter. The catheter includes a plurality of lumens within the catheter extending from the proximal end portion, a plurality of inflatable balloons positioned in the central portion and a secondary treatment balloon communicatively associated with the distal end portion of the catheter, and the balloons and the secondary treatment balloon being communicatively connected with a corresponding one of the plurality of lumens to selectively inflate/deflate the corresponding inflatable balloon or to receive a radioactive dose or a therapeutic agent for a treatment.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: November 29, 2022
    Assignee: Best Medical International, Inc.
    Inventor: Manny R. Subramanian
  • Patent number: 11471240
    Abstract: A system for dynamic localization of medical instruments includes an ultrasound imaging system (110) configured to image a volume where one or more medical instruments are deployed. A registration module (136) registers two images of the one or more medical instruments to compute a transform between the two images, the two images being separated in time. A planning module (142) is configured to have positions of the volume and the one or more medical instruments updated based on the transform and, in turn, update a treatment plan in accordance with the updated positions such that changes in the volume and positions of the one or more medical instruments are accounted for in the updated plan.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: October 18, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Ehsan Dehghan Marvast, Shyam Bharat, Jochen Kruecker
  • Patent number: 11439848
    Abstract: A template matching is performed on two fluoroscopic images by using a template image prepared in advance and a position corresponding to a high matching score is listed as a candidate for the position of a marker 29. From two lists of the candidates of the position of the marker 29, the lengths of common vertical lines for all combinations are calculated. Then, the position of the marker 29 is detected based on the matching score and the common vertical line. Then, based on the detected position of the marker 29, an amount of a proton beam to be irradiated to a target is controlled. Therefore, a tracking target can be accurately detected even when the conditions for X-ray fluoroscopy is severe, e.g., a thick object.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 13, 2022
    Assignees: HITACHI, LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Yusuke Fujii, Naoki Miyamoto, Kikuo Umegaki, Shinichi Shimizu, Toru Umekawa, Takahiro Yamada
  • Patent number: 11419827
    Abstract: Materials and methods for reducing, preventing, or mitigating the effects of exposure to ionizing radiation are provided herein. In general, the methods can include administering a nanoparticulate genistein composition to a subject identified as having been exposed or at risk of being exposed to ionizing radiation, such as proton radiation.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: August 23, 2022
    Assignee: Humanetics Corporation
    Inventors: Adam J. Harvey, Michael D. Kaytor, John C. Dykstra
  • Patent number: 11420077
    Abstract: A computer program product, method, system and device that acquires, by a radiation detector, exit radiation measurement information during delivery of patient treatment. Patient anatomy information is also received and a radiation detector response calibration is determined utilizing at least the exit radiation measurement information, the patient anatomy information, and at least a portion of a radiation treatment plan.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: August 23, 2022
    Assignee: SUN NUCLEAR CORPORATION
    Inventors: Amir Ramezanzadeh Moghadam, Jakub Kozelka
  • Patent number: 11413474
    Abstract: A method is proposed for evaluating the robustness of a radiotherapy treatment plan. The method comprises, defining a number of scenarios, each comprising one or more errors for each fraction of the plan, including interfractional and/or intrafractional errors, and calculating a dose distribution resulting from the scenario; The robustness of the plan is then evaluated based at least one of the following i. the probability of fulfilling a set of clinical goals estimated as the clinical goal fulfilment over the scenarios ii. the range of DVH values over the scenarios iii. dose statistics for dose distributions defined as voxel-wise aggregates over the scenario doses.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: August 16, 2022
    Assignee: RaySearch Laboratories AB
    Inventor: Albin Fredriksson
  • Patent number: 11389536
    Abstract: The present invention is directed to methods for the treatment of cancer with a combination of radiation, cerium oxide nanoparticles and at least one chemotherapeutic agent. Cerium oxide nanoparticles (CONPs) are nanometer-sized crystals of cerium oxide, typically ranging between about one nanometer to about 20 nanometers in longest dimension. The present methods use cerium oxide nanoparticles to enhance radiation-induced and chemotherapy-induced cancer cell death and also reduce the toxicity associated with radiation therapy and chemotherapy.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: July 19, 2022
    Assignee: BioCurity Pharmaceuticals Inc.
    Inventor: Cheryl Baker
  • Patent number: 11389168
    Abstract: A temporary aortic occlusion device is disclosed, having an expandable locator portion and an expandable occlusion portion. The expandable locator portion assists a user in determining whether the distal end of the device has been advanced within a patient's aorta, and the occlusion portion is expanded to occlude the patient's aorta, preferably below the renal arteries.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: July 19, 2022
    Assignees: MicroVention, Inc., University of Virginia Patent Foundation, United States of America as Represented by the Secretary of the Navy
    Inventors: George R. Greene, Jr., Ivan Sepetka, Cathy Lei, Rupal Nguyen, Matthew J. Bradley, Stephen T. Ahlers, Carl S. Goforth, James R. Stone
  • Patent number: 11383101
    Abstract: The present disclosure lies in the field of medical radiotherapy and relates to an applicator for a medical radiotherapy device, an applicator system for a medical radiotherapy device and a method for using an applicator or an applicator system. The applicator includes an applicator head and an applicator body. The applicator head and the applicator body are embodied such that the applicator head can be assembled on, and disassembled from, the applicator body, in each case without damage.
    Type: Grant
    Filed: September 27, 2020
    Date of Patent: July 12, 2022
    Assignee: Carl Zeiss Meditec AG
    Inventor: Frank Weigand
  • Patent number: 11385363
    Abstract: The present disclosure relates to a system for PET imaging. The system may include a first device and a second device. The first device may include a first scanning channel. The second device may include a second scanning channel connected to the first scanning channel, a heat generating component, and a cooling assembly configured to cool the heat generating component, wherein the cooling assembly may include an inlet chamber and a return chamber, the heat generating component may be closer to a first side of the second device than at least one of the inlet chamber or the return chamber, and the first side of the second device may face the first device.
    Type: Grant
    Filed: September 7, 2020
    Date of Patent: July 12, 2022
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Guanghe Wu, Weiping Liu, Shigang Su
  • Patent number: 11382792
    Abstract: The present invention relates to an ophthalmic treatment device, a control method therefor and a fundus lesion treatment method, the ophthalmic treatment device comprising: a treatment beam generation unit for generating a treatment beam; a beam delivery unit for forming a path through which the treatment beam generated from the treatment beam generating unit is irradiated into a patient's fundus; and a control unit for controlling the beam delivery unit to irradiate the treatment beam into a location adjacent to the lesion area of the fundus.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: July 12, 2022
    Assignee: Lutronic Vision Inc.
    Inventor: Jong Min Kim
  • Patent number: 11369804
    Abstract: System and methods may be used for arc fluence optimization without iteration to arc sequence generation. A method may include defining a particle arc range for a radiotherapy treatment of a patient, and generating an arc sequence, including a set of parameters for delivering the radiotherapy treatment, without requiring a dose calculation. The method may include optimizing fluence of the arc sequence for the radiotherapy treatment without iterating back to arc sequence generation, and outputting the fluence optimized arc sequence for use in the radiotherapy treatment.
    Type: Grant
    Filed: April 27, 2021
    Date of Patent: June 28, 2022
    Assignee: Elekta, Inc.
    Inventors: Martin Soukup, Kun-Yu Tsai
  • Patent number: 11364087
    Abstract: The present invention provides a method and apparatus to decrease acute and late skin toxicity for breast cancer patients undergoing radiation therapy. This invention will enable better breast positioning during therapy, eliminating skin folds and reducing the skin dose below that required for development of moist desquamation. The present invention has the potential to reduce the volume of normal tissue and organs at risk of being irradiated during a course of whole breast radiation therapy.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: June 21, 2022
    Assignee: Provincial Health Services Authority
    Inventors: Cheryl Moldon, Scott Young, Robin Coope, Tania Arora, Keri Smith, Christina Cumayas, Bradford Gill
  • Patent number: 11364231
    Abstract: The present disclosure is directed to method of treatment for treating or ameliorating various conditions caused by radiation exposure such as RIGS, enteritis, oral mucositis, mucositis, and proctitis by the administration of a compound Yel002/BCN057 or an analog thereof.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: June 21, 2022
    Assignees: University of Kansas, BCN Biosciences L.L.C.
    Inventors: Subhrajit Saha, Andrew J. Norris
  • Patent number: 11344526
    Abstract: Provided herein are drug implants comprising a therapeutically active agent for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and a therapeutically active agent disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may comprise bicalutamide, e.g., for use in the treatment of prostate cancer.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: May 31, 2022
    Assignees: The Regents of the University of California, Alessa Therapeutics, Inc.
    Inventors: Maithili Rairkar, Pujan Desai, Carlos Schuler, Maxime Daud, Maxime D. Rappaport, Pamela Munster, John Maroney, Margaret McLaughlin, Tobias H. Casab, Keith Hall, Scott Thomas
  • Patent number: 11317983
    Abstract: A surgical probe system comprising a surgical probe having an instrument tip, and at least one motion sensor located within the surgical probe that measures movement and orientation data. The system further includes a processor that is configured to determine movement and orientation of the instrument tip based on the movement and orientation data, and adjust at least one surgical parameter of the surgical probe based on the movement and orientation of the instrument tip to affect a predetermined surgical outcome.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: May 3, 2022
    Assignee: Alcon Inc.
    Inventors: Steven T. Charles, Tammo Heeren
  • Patent number: 11308590
    Abstract: This disclosure provides a system and method for generating an ultrasound image. The method includes receiving a raw ultrasound signal output from an ultrasound device and performing operations to transform the raw ultrasound signal into an enhanced ultrasound image. The enhanced ultrasound image may be further processed by radial symmetry filtering to generate a radial symmetry image. Both the enhanced image and the radial symmetry image can be by a medical practitioner to make a liver or kidney cancer diagnosis exclusively based on ultrasound data.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: April 19, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: John Nosher, Ilker Hacihaliloglu
  • Patent number: 11303009
    Abstract: System-in-package (SiP) devices are disclosed that include power amplifiers and controllers such as beamformer integrated circuits that are packaged together. Packaging and thermal management configurations are disclosed that allow a plurality of power amplifiers and a beamformer integrated circuit to operate efficiently while in close proximity to one another. SiP devices are disclosed that include heat spreaders that are incorporated within the SiP devices and exposed at top surfaces of the SiP devices to effectively dissipate heat. Heat spreaders may be provided as part of a lead frame that allows multiple SiP devices to be uniformly assembled with dimensions sized for high frequency applications, including millimeter wave operation.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: April 12, 2022
    Assignee: QORVO US, INC.
    Inventors: Anthony Chiu, Bror Peterson, Michael Arnold
  • Patent number: 11291859
    Abstract: Information that describes a target inside a patient to be treated with radiation is accessed from computer system memory. An arrangement of spots inside the target is determined. Each the spots corresponds to a location inside the target where a respective beam of radiation is to be directed during radiation treatment of the patient. A dose rate for each of the beams is determined. The dose rate for each beam is a dose delivered in less than one second to a spot corresponding to that beam. For example, each beam can deliver at least four grays (GY) in less than one second, and may deliver as much as 20 Gy to 50 Gy or 100 Gy or more in less than one second. A radiation treatment plan, that includes the arrangement of the spots and the dose rate for each of the beams, is stored in computer system memory.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: April 5, 2022
    Assignee: Varian Medical Systems, Inc.
    Inventors: Eric Abel, Alexander Katsis
  • Patent number: 11273327
    Abstract: A virtual beam's-eye view of a planning target volume is generated based on volumetric image data acquired immediately prior to radiation therapy by a radiation therapy system. The virtual beam's-eye view can then be displayed to confirm that, with the patient disposed in the current position, the planned beam-delivered treatment extends beyond the surface of the skin. In some embodiments, the virtual beam's-eye view can be displayed in conjunction with a beam's-eye view that is generated based on volumetric image data acquired during treatment planning, to create a blended beam's-eye view. In some embodiments, a field outline of a treatment beam can be superimposed on the blended beam's-eye view, thereby illustrating whether the planned beam-delivered treatment extends beyond the surface of the skin of the patient. The blended beam's-eye view can facilitate a manual confirmation process that verifies the planned beam-delivered treatment extends beyond the surface of the skin.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: March 15, 2022
    Inventors: Stefan Thieme-Marti, Andres Graf, Christof Sidler
  • Patent number: 11260246
    Abstract: Apparatus and methods for controlling a radiotherapy electron beam. Exemplary embodiments provide for focusing the electron beam at different depths by altering parameters of a plurality of magnets. Exemplary embodiments can also provide for focusing the electron beam at different depths while maintaining the energy level of the electron beam at a consistent level.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: March 1, 2022
    Assignees: Board of Regents, The University of Texas System, Tel-Hashomer Medical Research Infrastructure and Services Ltd. at the Chaim Sheba Medical Center
    Inventors: Dirk Bartkoski, Dror Alezra, Mohammad Salehpour, Thomas Buchholz
  • Patent number: 11235171
    Abstract: Systems, devices, and methods for non-Gaussian energy distribution modeling for treatment planning algorithms used in particle radiation therapy.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: February 1, 2022
    Assignee: VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH & CO. KG
    Inventor: Joerg Wulff
  • Patent number: 11191979
    Abstract: Systems, devices, and methods for dosimetric verification of radiation therapy treatments by selective evaluation of measurement points. Systems, methods, and computer program-products for providing dosimetric verification of radiation therapy treatments by evaluating measurement points using different evaluation criteria.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: December 7, 2021
    Assignee: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
    Inventors: Janne Nord, Lasse Heikki Toimela
  • Patent number: 11154725
    Abstract: Devices, systems, and methods for planning radiosurgical treatments for neuromodulating a portion of the renovascular system may be used to plan radiosurgical neuromodulation treatments for conditions or disease associated with elevated central sympathetic drive. The renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as preganglionic positions. Target regions include the renal plexus, celiac ganglion, the superior mesenteric ganglion, the aorticorenal ganglion and the aortic plexus. Planning of radiosurgical treatments will optionally employ a graphical representation of a blood/tissue interface adjacent these targets.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: October 26, 2021
    Assignee: Varian Medical Systems, Inc.
    Inventors: Patrick Maguire, Edward Gardner
  • Patent number: 11147986
    Abstract: The effects of acute toxicity from a radiation procedure can be reduced without altering the radiation dose by temporally feathering the radiation procedure. Using temporal feathering, the radiation procedure delivers a total amount of radiation that is weighted amounts of radiation per day. The weighted amounts of radiation can be delivered according to a sequence plan that ensures the total dose of radiation is administered in the time period. The sequence plan includes one day of a high fractional dose of radiation and four days of a low fractional dose of radiation.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: October 19, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Jacob Scott
  • Patent number: 11123574
    Abstract: In order to assess the achievability of treatment goals for a radiation therapy treatment, an estimation unit generates a treatment plan for the radiation therapy treatment only on the basis of treatment goals relating to a target structure to obtain a first dose distribution, (i) segments the region of the patient's body into a plurality of concentric shells surrounding the target structure and determines a mean radiation dose assigned to each shell in accordance with the first dose distribution, and (iii) checks whether a further dose distribution can be determined, which fulfills the treatment goals relating to at least one structure at risk and, which is configured such that the mean radiation dose assigned to each shell in accordance with the further dose distribution corresponds to the mean radiation dose assigned to the same shell in accordance with the first dose distribution.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: September 21, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Prashant Kumar, Vaitheeswaran Ranganathan
  • Patent number: 11103730
    Abstract: An example particle therapy system includes a particle beam output device to direct output of a particle beam; a treatment couch to support a patient containing an irradiation target, with the treatment couch being configured for movement; a movable device on which the particle beam output device is mounted for movement relative to the treatment couch; and a control system to provide automated control of at least one of the movable device or the treatment couch to position at least one of the particle beam or the irradiation target for treatment of the irradiation target with the particle beam and, following the treatment of the irradiation target with the particle beam, to provide automated control of at least one of the movable device or the treatment couch to reposition at least one of the particle beam or the irradiation target for additional treatment of the irradiation target with the particle beam.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: August 31, 2021
    Assignee: MEVION MEDICAL SYSTEMS, INC.
    Inventors: Gerrit Townsend Zwart, Mark R. Jones, James Cooley, Stanley J. Rosenthal
  • Patent number: 11103729
    Abstract: Systems and methods are provided for registering images. The systems and methods perform operations comprising: receiving, at a first time point in a given radiation session, a first imaging slice corresponding to a first plane; encoding the first imaging slice to a lower dimensional representation; applying a trained machine learning model to the encoded first imaging slice to estimate an encoded version of a second imaging slice corresponding to a second plane at the first time point to provide a pair of imaging slices for the first time point; simultaneously spatially registering the pair of imaging slices to a volumetric image, received prior to the given radiation session, comprising a time-varying object to calculate displacement of the object; and generating an updated therapy protocol to control delivery of a therapy beam based on the calculated displacement of the object.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: August 31, 2021
    Assignee: Elekta LTD
    Inventors: Martin Emile Lachaine, Silvain BĂ©riault
  • Patent number: 11100632
    Abstract: A statistical learning technique that does not rely upon paired imaging information is described herein. The technique may be computer-implemented and may be used in order to train a statistical learning model to perform image synthesis, such as in support of radiation therapy treatment planning. In an example, a trained statistical learning model may include a convolutional neural network established as a generator convolutional network, and the generator may be trained at least in part using a separate convolutional neural network established as a discriminator convolutional network. The generator convolutional network and the discriminator convolutional network may form an adversarial network architecture for use during training. After training, the generator convolutional network may be provided for use in synthesis of images, such as to receive imaging data corresponding to a first imaging modality type, and to synthesize imaging data corresponding to a different, second imaging modality type.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: August 24, 2021
    Assignee: Elekta, Inc.
    Inventor: Xiao Han
  • Patent number: 11097127
    Abstract: A system that generates a three-dimensional model of a tissue surface, for example the inner surface of the heart from two-dimensional image data slices. On this surface, one or more pattern lines are drawn, e.g., by a physician using a user interface, to designate desired lesion(s) on the surface. From the pattern lines, a three-dimensional volume for a lesion can be determined using known constraints. Advantageously, the series of boundaries generated by the three-dimensional volume may be projected back onto the individual CT scans, which then may be transferred to a standard radiosurgical planning tool. A dose cloud may also be projected on the model to aid in evaluating a plan.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: August 24, 2021
    Assignee: Varian Medical Systems, Inc.
    Inventors: Thilaka Sumanaweera, Ed Gardner, Oliver Blanck, Tao Cai, Darrin Uecker, Patrick Maguire
  • Patent number: 11090190
    Abstract: A method that includes illuminating an eye with light at a first time and a second time and generating a first image of the eye based on the light that illuminates the eye at the first time. The method includes generating a second image of the eye based on the light that illuminates the eye at the second time. The method further includes positioning a laser source relative to the eye, wherein the laser source generates a therapeutic laser beam to be directed to the eye, wherein the first time is just prior to the therapeutic laser beam being directed to the eye and the second time is prior to the first time. The method further includes correcting orientation of the laser source relative to the eye based on a correlation function that is defined for the first and second images of the eye.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: August 17, 2021
    Assignee: Lensar, Inc.
    Inventor: Dustin Morley
  • Patent number: 11083911
    Abstract: A radiation therapy system (100) includes a radiation therapy (RT) optimizer unit (102) and an interactive planning interface unit (120). The RT optimizer unit (102) receives at least one target structure and at least one organ-at-risk (OAR) structure segmented from a volumetric image (108), and generates an optimized RT plan (140) based on dose objectives (200-204, 210-222, 320), at least one dose objective of the dose objectives corresponding to each of the at least one target structure (210-222) and the at least one OAR structure (200-204). The optimized RT plan includes a planned radiation dose for each voxel of the volumetric image using external beam radiation therapy, wherein the RT optimizer unit operates iteratively.
    Type: Grant
    Filed: April 1, 2017
    Date of Patent: August 10, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Gipson Joe Anto, Sivaramakrishnan Krishnaiyer Raman, Vaitheeswaran Ranganathan
  • Patent number: 11078278
    Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: August 3, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jason Samuel Simon, Petra B. Ross-Macdonald
  • Patent number: 11058897
    Abstract: An electron accelerator including a resonant cavity, an electron source, an RF system, and at least one magnet unit is provided. The resonant cavity further includes a hollow closed conductor and the electron source is configured to radially inject a beam of electrons into the cavity. The RF system is configured to generate an electric field to accelerate the electrons along radial trajectories. The at least one magnet unit further-includes a deflecting magnet configured to generate a magnetic field that deflects an electron beam emerging out of the resonant cavity along a first radial trajectory and redirects the electron beam into the resonant cavity along a second radial trajectory. The resonant cavity further includes a first half shell, a second half shell, and a central ring element.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: July 13, 2021
    Assignee: Ion Beam Applications S.A.
    Inventor: Raphael Van Roermund
  • Patent number: 11045665
    Abstract: An ophthalmic radiation device having a substantially light-transparent wand configured to emit light propagating through the wand light from a series of illumination ports at least partially circumscribing a radioactive source disposed in the holder, thereby providing a visual reference for identifying a position of the radioactive source. Embodiments are directed at effectively directing light from a light source through the body of the wand to illumination ports by using the wand body itself as the light guide. The illumination ports are used as reference points by a medical practitioner to facilitate placing the device into a correct treatment position.
    Type: Grant
    Filed: January 5, 2019
    Date of Patent: June 29, 2021
    Assignee: IP Liberty Vision Corporation
    Inventors: Paul T. Finger, Toby Welles
  • Patent number: 11046768
    Abstract: Provided herein are compositions, methods, and uses involving bispecific binding molecules that specifically bind to HER2, a receptor tyrosine kinase, and to CD3, a T cell receptor, and mediate T cell cytotoxicity for managing and treating disorders, such as cancer. Also provided herein are uses and methods for managing and treating HER2-related cancers.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: June 29, 2021
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Nai-Kong V. Cheung, Andres Lopez-Albaitero, Hong Xu
  • Patent number: 11045351
    Abstract: A light-guided, ophthalmic-treatment-system for administering therapeutic agents to, into or through the scleral wall of the eye globe using any one of a variety of therapeutic applicators in conjunction with either transcorneal or transpupillary viewing methods or both.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: June 29, 2021
    Assignee: IP LIBERTY VISION CORPORATION
    Inventors: Paul T. Finger, Toby Welles
  • Patent number: 11040221
    Abstract: Systems and methods are provided for registering images. The systems and methods perform operations comprising: receiving, at a first time point during a given radiation session, a first imaging slice comprising an object, the first imaging slice corresponding to a first plane; accessing, at the first time point during the given radiation session, a composite imaging slice corresponding to the first plane, the composite imaging slice being generated using a plurality of imaging slices obtained prior to the first time point; spatially registering the first imaging slice and the composite imaging slice; determining movement of the object using the spatially registered first imaging slice and the composite imaging slice; and generating an updated therapy protocol to control delivery of a therapy beam based on the determined movement.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: June 22, 2021
    Assignee: Elekta LTD.
    Inventors: Martin Emile Lachaine, Francois Paul George Rene Hebert
  • Patent number: 11033755
    Abstract: There is provided a treatment planning system and a particle therapy system. In the related art, it is unable to determine optimum beam intensity in irradiation for which discrete spot irradiation and continuous beam irradiation coexist. There is provided a treatment planning system that includes a spot determination unit that divides an irradiation region to be irradiated with a charged particle beam into a plurality of layers in an advancing direction of the charged particle beam and disposes a plurality of irradiation spots, which becomes irradiation points of the charged particle beam, in the layers and a beam intensity determination unit that determines beam intensity for each of the layers by evaluating the irradiation time by changing the beam intensity in a range of a condition of change in dose distribution which is set in advance.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: June 15, 2021
    Assignee: HITACHI, LTD.
    Inventors: Takahiro Yamada, Taisuke Takayanagi, Rintarou Fujimoto, Shinichiro Fujitaka, Takuya Nomura
  • Patent number: 11029418
    Abstract: Methods and apparatus for calibrating radioactive sources are described. An array of scintillation detectors forms a receptacle within which a sample or sample container can be retained by a holder. The scintillation detectors are coupled via light transducers such as photomultiplier tubes (PMTs) to independent electronic counters. Coincidence processing of time-tagged events yields a correlated event rate. One or more corrections can be applied as needed, for background counts, deadtime, or random coincidences. Voltage tuning of PMTs yields improved reproducibility. Accuracy of 1% has been demonstrated over a range of 10 kBq-3 MBq.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: June 8, 2021
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventor: Stephen S. Adler
  • Patent number: 11020614
    Abstract: A radiation therapy planning system (100) includes a radiation therapy optimization unit (124), which receives at least one target structure and at least one organ-at-risk (OAR) structure segmented from a volumetric image, and generates an optimized plan (126) based on at least one modified objective function. The optimized plan (126) includes a planned radiation dose for each voxel.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: June 1, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Karl Antonin Bzdusek, Prashant Kumar
  • Patent number: 11011264
    Abstract: Example methods and systems for radiotherapy treatment planning are provided. One example method may comprise obtaining image data associated with a patient; and processing the image data to generate a treatment plan for the patient using an inferential chain that includes multiple AI engines that are trained separately to perform respective multiple treatment planning steps. A first treatment planning step may be performed using a first AI engine to generate first output data based on at least one of: (i) the image data, and (ii) first input data generated based on the image data. A second treatment planning step may be performed using a second AI engine to generate the treatment plan based on at least one of: (i) the first output data, and (ii) second input data generated based on the first output data.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: May 18, 2021
    Inventors: Corey Zankowski, Charles Adelsheim, Joakim Pyyry, Esa Kuusela
  • Patent number: 10984902
    Abstract: Example methods for adaptive radiotherapy treatment planning using deep learning engines are provided. One example method may comprise obtaining treatment image data associated with a first imaging modality. The treatment image data may be acquired during a treatment phase of a patient. Also, planning image data associated with a second imaging modality may be acquired prior to the treatment phase to generate a treatment plan for the patient. The method may also comprise: in response to determination that an update of the treatment plan is required, transforming the treatment image data associated with the first imaging modality to generate transformed image data associated with the second imaging modality. The method may further comprise: processing, using the deep learning engine, the transformed image data to generate output data for updating the treatment plan.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 20, 2021
    Inventors: Hannu Laaksonen, Janne Nord, Sami Petri Perttu
  • Patent number: 10955365
    Abstract: A neutron generator has a neutron source generating an ion beam bombarding a Titanium target having a first diameter, the target embedded in a pre-moderator, emitting fast neutrons isotropically, a portion of the fast neutrons moderated in passing through the pre-moderator and exiting through a lowermost surface of the pre-moderator, and a plate of moderating material abutting the lowermost surface of the pre-moderator, the plate having an opening therethrough in a shape of a truncated cone with an axis aligning with direction of the ion beam, a depth, a major diameter of at the upper surface of the plate and a minor diameter at the lower surface of the plate, the opening forming a funnel through which neutrons pass. Neutrons enter the funnel and are to exit through the minor diameter of the funnel, providing a neutron beam with a spot size useful for neutron radiography.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: March 23, 2021
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Jay Theodore Cremer, Jr., Charles Kevin Gary, David Lowndes Williams, Allan Xi Chen, Glenn Emerson Jones, Jr., Yao Zong Guan, Randall Scott Urdahl, Adam Nathaniel Amoroso
  • Patent number: 10946217
    Abstract: Methods of beam angle optimization for intensity modulated radiotherapy (IMRT) treatment include determining beam's eye view (BEV) regions and a BEV region connectivity manifold by evaluating dose response of each region of interest for each vertex in a delivery coordinate space (DCS). The information contained in the BEV regions and the BEV region connectivity manifold is used to guide an optimizer to find optimal field geometries in the IMRT treatment. To improve the visibility of insufficiently exposed voxels of planning target volumes (PTVs), a post-processing step may be performed to enlarge certain BEV regions, which are considered for exposing during treatment trajectory optimization.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: March 16, 2021
    Assignees: Varian Medical Systems International AG, The Board of Trustees of the Leland Stanford Junior University, Office of the General Counsel
    Inventors: Christopher Barry Locke, Santtu Ollila, Karl Kenneth Bush
  • Patent number: 10938643
    Abstract: A control module for a distributed sensor system can include a non-application specific configurable module configured to operate as a function of controller configuration settings data, at least a first memory configured to store the controller configuration settings data, at least one external interface module configured to connect with a master host module of the sensor system to receive updated controller configuration settings data, the control module configured to receive and store the updated controller configuration settings in the first memory thereof via the at least one external interface module, and a subnet interface module configured to connect to one or more configurable sensor nodes on a subnetwork, wherein the control module is configured to control and/or configure the one or more sensor nodes as a function of the controller configuration setting data and receive sensor data from the one or more sensor nodes.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: March 2, 2021
    Assignee: Simmonds Precision Products, Inc.
    Inventors: Benjamin T. Rule, Travis Gang, Thomas Henck, Travis Dement, Peter J. Carini, Daniel Hiatt, Benjamin D. Mcbride, Matthew B. Burleigh