Radioactive Substance Applied To Body For Therapy Patents (Class 600/1)
  • Patent number: 11191979
    Abstract: Systems, devices, and methods for dosimetric verification of radiation therapy treatments by selective evaluation of measurement points. Systems, methods, and computer program-products for providing dosimetric verification of radiation therapy treatments by evaluating measurement points using different evaluation criteria.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: December 7, 2021
    Assignee: VARIAN MEDICAL SYSTEMS INTERNATIONAL AG
    Inventors: Janne Nord, Lasse Heikki Toimela
  • Patent number: 11154725
    Abstract: Devices, systems, and methods for planning radiosurgical treatments for neuromodulating a portion of the renovascular system may be used to plan radiosurgical neuromodulation treatments for conditions or disease associated with elevated central sympathetic drive. The renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as preganglionic positions. Target regions include the renal plexus, celiac ganglion, the superior mesenteric ganglion, the aorticorenal ganglion and the aortic plexus. Planning of radiosurgical treatments will optionally employ a graphical representation of a blood/tissue interface adjacent these targets.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: October 26, 2021
    Assignee: Varian Medical Systems, Inc.
    Inventors: Patrick Maguire, Edward Gardner
  • Patent number: 11147986
    Abstract: The effects of acute toxicity from a radiation procedure can be reduced without altering the radiation dose by temporally feathering the radiation procedure. Using temporal feathering, the radiation procedure delivers a total amount of radiation that is weighted amounts of radiation per day. The weighted amounts of radiation can be delivered according to a sequence plan that ensures the total dose of radiation is administered in the time period. The sequence plan includes one day of a high fractional dose of radiation and four days of a low fractional dose of radiation.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: October 19, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Jacob Scott
  • Patent number: 11123574
    Abstract: In order to assess the achievability of treatment goals for a radiation therapy treatment, an estimation unit generates a treatment plan for the radiation therapy treatment only on the basis of treatment goals relating to a target structure to obtain a first dose distribution, (i) segments the region of the patient's body into a plurality of concentric shells surrounding the target structure and determines a mean radiation dose assigned to each shell in accordance with the first dose distribution, and (iii) checks whether a further dose distribution can be determined, which fulfills the treatment goals relating to at least one structure at risk and, which is configured such that the mean radiation dose assigned to each shell in accordance with the further dose distribution corresponds to the mean radiation dose assigned to the same shell in accordance with the first dose distribution.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: September 21, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Prashant Kumar, Vaitheeswaran Ranganathan
  • Patent number: 11103730
    Abstract: An example particle therapy system includes a particle beam output device to direct output of a particle beam; a treatment couch to support a patient containing an irradiation target, with the treatment couch being configured for movement; a movable device on which the particle beam output device is mounted for movement relative to the treatment couch; and a control system to provide automated control of at least one of the movable device or the treatment couch to position at least one of the particle beam or the irradiation target for treatment of the irradiation target with the particle beam and, following the treatment of the irradiation target with the particle beam, to provide automated control of at least one of the movable device or the treatment couch to reposition at least one of the particle beam or the irradiation target for additional treatment of the irradiation target with the particle beam.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: August 31, 2021
    Assignee: MEVION MEDICAL SYSTEMS, INC.
    Inventors: Gerrit Townsend Zwart, Mark R. Jones, James Cooley, Stanley J. Rosenthal
  • Patent number: 11103729
    Abstract: Systems and methods are provided for registering images. The systems and methods perform operations comprising: receiving, at a first time point in a given radiation session, a first imaging slice corresponding to a first plane; encoding the first imaging slice to a lower dimensional representation; applying a trained machine learning model to the encoded first imaging slice to estimate an encoded version of a second imaging slice corresponding to a second plane at the first time point to provide a pair of imaging slices for the first time point; simultaneously spatially registering the pair of imaging slices to a volumetric image, received prior to the given radiation session, comprising a time-varying object to calculate displacement of the object; and generating an updated therapy protocol to control delivery of a therapy beam based on the calculated displacement of the object.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: August 31, 2021
    Assignee: Elekta LTD
    Inventors: Martin Emile Lachaine, Silvain Bériault
  • Patent number: 11097127
    Abstract: A system that generates a three-dimensional model of a tissue surface, for example the inner surface of the heart from two-dimensional image data slices. On this surface, one or more pattern lines are drawn, e.g., by a physician using a user interface, to designate desired lesion(s) on the surface. From the pattern lines, a three-dimensional volume for a lesion can be determined using known constraints. Advantageously, the series of boundaries generated by the three-dimensional volume may be projected back onto the individual CT scans, which then may be transferred to a standard radiosurgical planning tool. A dose cloud may also be projected on the model to aid in evaluating a plan.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: August 24, 2021
    Assignee: Varian Medical Systems, Inc.
    Inventors: Thilaka Sumanaweera, Ed Gardner, Oliver Blanck, Tao Cai, Darrin Uecker, Patrick Maguire
  • Patent number: 11100632
    Abstract: A statistical learning technique that does not rely upon paired imaging information is described herein. The technique may be computer-implemented and may be used in order to train a statistical learning model to perform image synthesis, such as in support of radiation therapy treatment planning. In an example, a trained statistical learning model may include a convolutional neural network established as a generator convolutional network, and the generator may be trained at least in part using a separate convolutional neural network established as a discriminator convolutional network. The generator convolutional network and the discriminator convolutional network may form an adversarial network architecture for use during training. After training, the generator convolutional network may be provided for use in synthesis of images, such as to receive imaging data corresponding to a first imaging modality type, and to synthesize imaging data corresponding to a different, second imaging modality type.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: August 24, 2021
    Assignee: Elekta, Inc.
    Inventor: Xiao Han
  • Patent number: 11090190
    Abstract: A method that includes illuminating an eye with light at a first time and a second time and generating a first image of the eye based on the light that illuminates the eye at the first time. The method includes generating a second image of the eye based on the light that illuminates the eye at the second time. The method further includes positioning a laser source relative to the eye, wherein the laser source generates a therapeutic laser beam to be directed to the eye, wherein the first time is just prior to the therapeutic laser beam being directed to the eye and the second time is prior to the first time. The method further includes correcting orientation of the laser source relative to the eye based on a correlation function that is defined for the first and second images of the eye.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: August 17, 2021
    Assignee: Lensar, Inc.
    Inventor: Dustin Morley
  • Patent number: 11083911
    Abstract: A radiation therapy system (100) includes a radiation therapy (RT) optimizer unit (102) and an interactive planning interface unit (120). The RT optimizer unit (102) receives at least one target structure and at least one organ-at-risk (OAR) structure segmented from a volumetric image (108), and generates an optimized RT plan (140) based on dose objectives (200-204, 210-222, 320), at least one dose objective of the dose objectives corresponding to each of the at least one target structure (210-222) and the at least one OAR structure (200-204). The optimized RT plan includes a planned radiation dose for each voxel of the volumetric image using external beam radiation therapy, wherein the RT optimizer unit operates iteratively.
    Type: Grant
    Filed: April 1, 2017
    Date of Patent: August 10, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Gipson Joe Anto, Sivaramakrishnan Krishnaiyer Raman, Vaitheeswaran Ranganathan
  • Patent number: 11078278
    Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: August 3, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jason Samuel Simon, Petra B. Ross-Macdonald
  • Patent number: 11058897
    Abstract: An electron accelerator including a resonant cavity, an electron source, an RF system, and at least one magnet unit is provided. The resonant cavity further includes a hollow closed conductor and the electron source is configured to radially inject a beam of electrons into the cavity. The RF system is configured to generate an electric field to accelerate the electrons along radial trajectories. The at least one magnet unit further-includes a deflecting magnet configured to generate a magnetic field that deflects an electron beam emerging out of the resonant cavity along a first radial trajectory and redirects the electron beam into the resonant cavity along a second radial trajectory. The resonant cavity further includes a first half shell, a second half shell, and a central ring element.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: July 13, 2021
    Assignee: Ion Beam Applications S.A.
    Inventor: Raphael Van Roermund
  • Patent number: 11045351
    Abstract: A light-guided, ophthalmic-treatment-system for administering therapeutic agents to, into or through the scleral wall of the eye globe using any one of a variety of therapeutic applicators in conjunction with either transcorneal or transpupillary viewing methods or both.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: June 29, 2021
    Assignee: IP LIBERTY VISION CORPORATION
    Inventors: Paul T. Finger, Toby Welles
  • Patent number: 11045665
    Abstract: An ophthalmic radiation device having a substantially light-transparent wand configured to emit light propagating through the wand light from a series of illumination ports at least partially circumscribing a radioactive source disposed in the holder, thereby providing a visual reference for identifying a position of the radioactive source. Embodiments are directed at effectively directing light from a light source through the body of the wand to illumination ports by using the wand body itself as the light guide. The illumination ports are used as reference points by a medical practitioner to facilitate placing the device into a correct treatment position.
    Type: Grant
    Filed: January 5, 2019
    Date of Patent: June 29, 2021
    Assignee: IP Liberty Vision Corporation
    Inventors: Paul T. Finger, Toby Welles
  • Patent number: 11046768
    Abstract: Provided herein are compositions, methods, and uses involving bispecific binding molecules that specifically bind to HER2, a receptor tyrosine kinase, and to CD3, a T cell receptor, and mediate T cell cytotoxicity for managing and treating disorders, such as cancer. Also provided herein are uses and methods for managing and treating HER2-related cancers.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: June 29, 2021
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Nai-Kong V. Cheung, Andres Lopez-Albaitero, Hong Xu
  • Patent number: 11040221
    Abstract: Systems and methods are provided for registering images. The systems and methods perform operations comprising: receiving, at a first time point during a given radiation session, a first imaging slice comprising an object, the first imaging slice corresponding to a first plane; accessing, at the first time point during the given radiation session, a composite imaging slice corresponding to the first plane, the composite imaging slice being generated using a plurality of imaging slices obtained prior to the first time point; spatially registering the first imaging slice and the composite imaging slice; determining movement of the object using the spatially registered first imaging slice and the composite imaging slice; and generating an updated therapy protocol to control delivery of a therapy beam based on the determined movement.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: June 22, 2021
    Assignee: Elekta LTD.
    Inventors: Martin Emile Lachaine, Francois Paul George Rene Hebert
  • Patent number: 11033755
    Abstract: There is provided a treatment planning system and a particle therapy system. In the related art, it is unable to determine optimum beam intensity in irradiation for which discrete spot irradiation and continuous beam irradiation coexist. There is provided a treatment planning system that includes a spot determination unit that divides an irradiation region to be irradiated with a charged particle beam into a plurality of layers in an advancing direction of the charged particle beam and disposes a plurality of irradiation spots, which becomes irradiation points of the charged particle beam, in the layers and a beam intensity determination unit that determines beam intensity for each of the layers by evaluating the irradiation time by changing the beam intensity in a range of a condition of change in dose distribution which is set in advance.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: June 15, 2021
    Assignee: HITACHI, LTD.
    Inventors: Takahiro Yamada, Taisuke Takayanagi, Rintarou Fujimoto, Shinichiro Fujitaka, Takuya Nomura
  • Patent number: 11029418
    Abstract: Methods and apparatus for calibrating radioactive sources are described. An array of scintillation detectors forms a receptacle within which a sample or sample container can be retained by a holder. The scintillation detectors are coupled via light transducers such as photomultiplier tubes (PMTs) to independent electronic counters. Coincidence processing of time-tagged events yields a correlated event rate. One or more corrections can be applied as needed, for background counts, deadtime, or random coincidences. Voltage tuning of PMTs yields improved reproducibility. Accuracy of 1% has been demonstrated over a range of 10 kBq-3 MBq.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: June 8, 2021
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventor: Stephen S. Adler
  • Patent number: 11020614
    Abstract: A radiation therapy planning system (100) includes a radiation therapy optimization unit (124), which receives at least one target structure and at least one organ-at-risk (OAR) structure segmented from a volumetric image, and generates an optimized plan (126) based on at least one modified objective function. The optimized plan (126) includes a planned radiation dose for each voxel.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: June 1, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Karl Antonin Bzdusek, Prashant Kumar
  • Patent number: 11011264
    Abstract: Example methods and systems for radiotherapy treatment planning are provided. One example method may comprise obtaining image data associated with a patient; and processing the image data to generate a treatment plan for the patient using an inferential chain that includes multiple AI engines that are trained separately to perform respective multiple treatment planning steps. A first treatment planning step may be performed using a first AI engine to generate first output data based on at least one of: (i) the image data, and (ii) first input data generated based on the image data. A second treatment planning step may be performed using a second AI engine to generate the treatment plan based on at least one of: (i) the first output data, and (ii) second input data generated based on the first output data.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: May 18, 2021
    Inventors: Corey Zankowski, Charles Adelsheim, Joakim Pyyry, Esa Kuusela
  • Patent number: 10984902
    Abstract: Example methods for adaptive radiotherapy treatment planning using deep learning engines are provided. One example method may comprise obtaining treatment image data associated with a first imaging modality. The treatment image data may be acquired during a treatment phase of a patient. Also, planning image data associated with a second imaging modality may be acquired prior to the treatment phase to generate a treatment plan for the patient. The method may also comprise: in response to determination that an update of the treatment plan is required, transforming the treatment image data associated with the first imaging modality to generate transformed image data associated with the second imaging modality. The method may further comprise: processing, using the deep learning engine, the transformed image data to generate output data for updating the treatment plan.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 20, 2021
    Inventors: Hannu Laaksonen, Janne Nord, Sami Petri Perttu
  • Patent number: 10955365
    Abstract: A neutron generator has a neutron source generating an ion beam bombarding a Titanium target having a first diameter, the target embedded in a pre-moderator, emitting fast neutrons isotropically, a portion of the fast neutrons moderated in passing through the pre-moderator and exiting through a lowermost surface of the pre-moderator, and a plate of moderating material abutting the lowermost surface of the pre-moderator, the plate having an opening therethrough in a shape of a truncated cone with an axis aligning with direction of the ion beam, a depth, a major diameter of at the upper surface of the plate and a minor diameter at the lower surface of the plate, the opening forming a funnel through which neutrons pass. Neutrons enter the funnel and are to exit through the minor diameter of the funnel, providing a neutron beam with a spot size useful for neutron radiography.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: March 23, 2021
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Jay Theodore Cremer, Jr., Charles Kevin Gary, David Lowndes Williams, Allan Xi Chen, Glenn Emerson Jones, Jr., Yao Zong Guan, Randall Scott Urdahl, Adam Nathaniel Amoroso
  • Patent number: 10946217
    Abstract: Methods of beam angle optimization for intensity modulated radiotherapy (IMRT) treatment include determining beam's eye view (BEV) regions and a BEV region connectivity manifold by evaluating dose response of each region of interest for each vertex in a delivery coordinate space (DCS). The information contained in the BEV regions and the BEV region connectivity manifold is used to guide an optimizer to find optimal field geometries in the IMRT treatment. To improve the visibility of insufficiently exposed voxels of planning target volumes (PTVs), a post-processing step may be performed to enlarge certain BEV regions, which are considered for exposing during treatment trajectory optimization.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: March 16, 2021
    Assignees: Varian Medical Systems International AG, The Board of Trustees of the Leland Stanford Junior University, Office of the General Counsel
    Inventors: Christopher Barry Locke, Santtu Ollila, Karl Kenneth Bush
  • Patent number: 10938643
    Abstract: A control module for a distributed sensor system can include a non-application specific configurable module configured to operate as a function of controller configuration settings data, at least a first memory configured to store the controller configuration settings data, at least one external interface module configured to connect with a master host module of the sensor system to receive updated controller configuration settings data, the control module configured to receive and store the updated controller configuration settings in the first memory thereof via the at least one external interface module, and a subnet interface module configured to connect to one or more configurable sensor nodes on a subnetwork, wherein the control module is configured to control and/or configure the one or more sensor nodes as a function of the controller configuration setting data and receive sensor data from the one or more sensor nodes.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: March 2, 2021
    Assignee: Simmonds Precision Products, Inc.
    Inventors: Benjamin T. Rule, Travis Gang, Thomas Henck, Travis Dement, Peter J. Carini, Daniel Hiatt, Benjamin D. Mcbride, Matthew B. Burleigh
  • Patent number: 10927417
    Abstract: Disclosed herein are assays and methods for the identification of premalignant lesions, as well as methods of determining the likelihood that such premalignant lesions will progress to lung cancer. Also disclosed are methods and assays that are useful for monitoring the progression of premalignant lesions to lung cancer. The assays and methods disclosed herein provide minimally invasive means of accurately detecting and monitoring the presence or absence of premalignant lesions, thus providing novel insights into the earliest stages of lung cancer and facilitating early detection and early intervention.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: February 23, 2021
    Assignee: Trustees of Boston University
    Inventors: Jennifer E. Beane-Ebel, Anna Tassinari, Avrum Spira, Marc E. Lenburg
  • Patent number: 10926108
    Abstract: The present disclosure provides a beam shaping assembly for neutron capture therapy, wherein the beam shaping assembly includes a neutron generating device, a moderator, a disturbing unit and a beam outlet. The neutron generating device is used to generate neutrons that form a neutron beam in a direction from the neutron generating device to the beam outlet, the moderator adjacent to the neutron generating device for adjusting fast neutrons in the neutron beam to epithermal neutrons. The disturbing unit is located between the moderator and the beam outlet for passing through the neutron beam and reducing the gamma ray content in the neutron beam passing through the beam outlet. The technical solution provided by the present disclosure can effectively reduce the gamma ray content in the neutron beam under the premise that the quality of the neutron beam is not significantly adversely affected.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: February 23, 2021
    Assignee: NEUBORON MEDTECH LTD.
    Inventors: Yuanhao Liu, Weilin Chen
  • Patent number: 10925147
    Abstract: An example method includes: receiving, from a treatment planning process, information that is based on a dose distribution for an irradiation target; and performing at least one of the following operations: moving structures to trim spots of a particle beam so that the spots of the particle beam approximate pre-trimmed spots for which characteristics are obtained based on the information received; moving structures to produce a trimming curve for a layer of an irradiation target based on a specification of a trimming curve for the layer included in the information received; moving structures to produce a single trimming curve for all radiation fields of an irradiation target based on specifications of the single trimming curve included in the information received; or moving structures based on configuration information for the structures in the information received.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: February 16, 2021
    Assignee: Mevion Medical Systems, Inc.
    Inventors: James Cooley, Gerrit Townsend Zwart, Stanley J. Rosenthal, Mark R. Jones, Lionel G. Bouchet, Robert Cessac, Joseph Jachinowski
  • Patent number: 10912599
    Abstract: Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: February 9, 2021
    Assignee: Zeltiq Aesthetics, Inc.
    Inventors: Michael P. O'Neil, Leonard C. DeBenedictis, George Frangineas, Jr.
  • Patent number: 10909722
    Abstract: The invention concerns a calibration target (30) of an optical system, formed of a plate (32) comprising through holes (38).
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: February 2, 2021
    Assignee: VIT
    Inventor: François Duplaix
  • Patent number: 10898734
    Abstract: A moveable support frame for a radiotherapy device, wherein the moveable support frame comprises at least one mass compensation mechanism, wherein the mass compensation mechanism comprises at least one resilient element.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: January 26, 2021
    Assignee: Elekta Limited
    Inventor: Danny Taminiau
  • Patent number: 10893840
    Abstract: According to one embodiment, an X-ray diagnostic apparatus includes a holding device and processing circuitry. The holding device movably holds an X-ray generator and an X-ray detector. The processing circuitry generates an X-ray image of the subject, based on an output of the X-ray detector. The processing circuitry sets an interference judgment region between the holding device and an interference object, based on a landmark in the X-ray image. The processing circuitry controls movement of the holding device, based on the set interference judgment region.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: January 19, 2021
    Assignee: Canon Medical Systems Corporation
    Inventors: Kazuo Imagawa, Yoshiyasu Hayashi, Masahiro Ozawa, Ko Fuchigami
  • Patent number: 10888711
    Abstract: In the field of radiotherapy, methods for dose or treatment planning for a radiotherapy system are disclosed, wherein a spatial dose delivered can be adjusted and delivered radiation is determined using an optimization problem that steers the delivered radiation according to a frame description reflecting criteria for regions of interest that include at least one of targets to be treated during treatment of the patient, organs at risk and/or healthy tissue. The method includes estimating a voxel set receiving a higher dose than a predetermined threshold dose level, which voxel set includes voxels from at least one target volume. Further, a low dose voxel set is determined and a frame description for the voxels in the low dose voxel set is provided where voxels receiving a dose exceeding a predetermined threshold value is penalized such that the dose delivered to the low dose voxel set is suppressed. The frame description is then used in the optimization problem that steers the delivered radiation.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: January 12, 2021
    Assignee: ELEKTA INSTRUMENTS AB
    Inventors: Håkan Nordström, Björn Somell, Stella Riad, Jens Sjölund
  • Patent number: 10881874
    Abstract: A radiation source that simultaneously produces two radiation frequencies of combined radiation, in order to break apart a mutated DNA base pair. The radiation source produces combined radiation, the combined radiation being for a thymine base and a cytosine base in a thymine and cytosine base pair. The radiation source produces combined radiation, the combined radiation being for a guanine base and a thymine base in a guanine and thymine base pair. The radiation source produces combined radiation, the combined radiation being for an adonine base and a guanine base in an adonine and guanine base pair. The radiation source produces combined radiation, the combined radiation being for an adonine base and a cytosine base in an adonine and cytosine base pair.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: January 5, 2021
    Inventor: John P. Tarlano
  • Patent number: 10874878
    Abstract: The present disclosure relates to a particle therapy apparatus for irradiating a target with a charged particle beam. In one implementation, the apparatus includes an isocentric gantry rotatable about an axis and configured to direct a particle beam towards an isocenter of gantry and according to a final beam direction, a magnetic resonance imaging system configured to generate a main magnetic field parallel to the final beam direction, and a passive magnetic shield surrounding the magnetic resonance imaging system, the passive magnetic shield and the magnetic resonance imaging system being synchronously rotatable with the gantry about the axis.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: December 29, 2020
    Assignee: Ion Beam Applications S.A.
    Inventor: Caterina Brusasco
  • Patent number: 10874880
    Abstract: A method for automation and integration inside a same setting of the characterization of a beam accelerator and the verification of a radiotherapy treatment based on the use of a detection medium and its control in a remote way. The reading of the detector subsystem placed on the flat mannequin is calibrated and dosimetric response of the detector subsystem is obtained in automated matter. 3D reconstruction of the radiotherapy treatment is applied on the detector subsystem based on measurements taken with the detector subsystem in the axial plane. Verification and automated visualization of a dose map reconstructed from the measurements taken with the detector subsystem with the dose map is obtained with a planning system.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: December 29, 2020
    Inventor: Maria Del Carmen Ovejero Mayoral
  • Patent number: 10874881
    Abstract: A treatment system for evaluating boron sources for boron neutron cancer therapy (BNCT) has a substantially square secondary moderator having a central treatment chamber for a subject; and four substantially identical neutron generators positioned around the substantially square secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: December 29, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10870020
    Abstract: A Boron neutron cancer treatment system has a secondary moderator having a central treatment chamber for a subject, and eight substantially identical neutron generators, each comprising a pre-moderator block. The eight neutron generators are positioned around the secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber, and with the angled sides of the neutron generators fully adjacent.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: December 22, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10870017
    Abstract: The present invention teaches a method and system for computing an alternative electron density map of an examination volume. The processing system is configured to compute a first electron density map using a plurality of imaging data, compute a second electron density map, wherein the second electron density map is a simplified version of the first electron density map, and compute the alternative electron density map, using the first electron density map and the second electron density map.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 22, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Steffen Renisch, Nicole Schadewaldt, Sven Prevrhal, Heinrich Schulz, Thomas Blaffert
  • Patent number: 10870018
    Abstract: Apparatus and methods for controlling a radiotherapy electron beam. Exemplary embodiments provide for focusing the electron beam at different depths by altering parameters of a plurality of magnets. Exemplary embodiments can also provide for focusing the electron beam at different depths while maintaining the energy level of the electron beam at a consistent level.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: December 22, 2020
    Assignees: Board of Regents, The University of Texas System, Tel-Hashomer Medical Research Infrastructure and Services Ltd. at the Chaim Sheba Medical Center
    Inventors: Dirk Bartkoski, Dror Alezra, Mohammad Salehpour, Thomas Buchholz
  • Patent number: 10857386
    Abstract: A system and method are provided for generating and delivering a volumetric modulated arc therapy (“VMAT”) plan to a patient. In some aspects, the method includes receiving a representation of a patient comprising information related to target and non-target volumes of interest and generating an objective function based on the representation of the patient. The method also includes performing an iterative optimization process using the objective function to generate a VMAT plan and generating a report according to the VMAT plan.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: December 8, 2020
    Assignee: The Regents of the University of California
    Inventor: Ke Sheng
  • Patent number: 10850131
    Abstract: A Boron neutron cancer treatment system has a moderator chamber filled with liquid or granular moderator material except for a central treatment chamber, the moderator chamber having parallel upper and lower surfaces, and a plurality of modular neutron generators fully immersed in the liquid or granular moderator material of the moderator chamber.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: December 1, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10850123
    Abstract: Provided in the present disclosure is a treatment planning method comprising, acquiring a preset dose distribution scheme; generating a plurality of radiation dose distribution schemes according to a preset algorithm and equipment parameters of a radiotherapy system, wherein the equipment parameters of a radiotherapy system comprises one or more of the radiation energy, parameters of radiation field, radiation angle, dose distribution at different radiation angles, and radiation time; comparing the plurality of radiation dose distribution schemes to the preset dose distribution scheme, to determine at least one radiation dose distribution scheme that is closest to the preset dose distribution scheme; and making a treatment plan according to the determined radiation dose distribution scheme.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: December 1, 2020
    Assignee: CYBER MEDICAL CORPORATION LIMITED
    Inventor: Haifeng Liu
  • Patent number: 10849571
    Abstract: The invention relates to a device (40) for standard uptake value, SUV, determination during an emission tomography imaging procedure of a patient. The device receives SUV-related data required for SUV determination, and event data relating to one or more events that may affect the SUV determination. The SUV-related data includes a time of administration of the radiotracer dose to the patient. The event data includes at least one of: a time at which an emission tomography imaging procedure of the patient is performed, patient motion data, patient position data, and patient vital signs data. An anomalous event determination unit (42) determines, based on the event data, anomalous event information indicative of one or more anomalous events that affect the SUV determination. An SUV determination unit (43) determines the SUV based on said SUV-related data taking into account the anomalous event information.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: December 1, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Andreia Maria Araujo Trindade Rodrigues, Pedro Jorge Da Silva Rodrigues, Andreas Goedicke
  • Patent number: 10850122
    Abstract: An optimization technique for use with radiation therapy planning that combines stochastic optimization techniques such as Particle Swarm Optimization (PSO) with deterministic techniques to solve for optimal and reliable locations for delivery of radiation doses to a targeted tumor while minimizing the radiation dose experienced by the surrounding critical structures such as normal tissues and organs.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: December 1, 2020
    Assignee: STC.UNM
    Inventors: Shuang Luan, Daniel Andres Riofrio Almeida
  • Patent number: 10850130
    Abstract: A Boron neutron cancer treatment system has a central treatment chamber for a subject, with six substantially identical neutron generators each having an acceleration chamber, the generators positioned around a secondary moderator with the axis of each acceleration chamber passing through center of the treatment chamber, and with angled sides of the neutron generators fully adjacent.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: December 1, 2020
    Assignee: Adelphi Technology, Inc.
    Inventors: Melvin Arthur Piestrup, Craig Mathew Brown, Allan Xi Chen, Charles Kevin Gary, Yao Zong Guan, Yoshio Horii, Glenn Emerson Jones, Jr., Yuji Kokubo, Naoyuki Yamada, Shotaro Komura
  • Patent number: 10849784
    Abstract: A method of treating a skin tissue relief feature (3) in mammalian, in particular human, skin tissue (1) is provided. The method comprises the steps of: determining a perimeter (4) of the relief feature and inducing contraction of skin tissue areas (5) present on opposite sides of the relief feature in positions adjacent to respective portions of the perimeter in a direction of contraction substantially parallel to a skin surface and substantially normal to the respective portions of the perimeter. A system is also provided comprising a radio-frequency source (9) and an applicator with a roller.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: December 1, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Martin Jurna, Jonathan Alambra Palero, Margaret Horton
  • Patent number: 10843008
    Abstract: The present disclosure relates to a system, a method, a computer program and a computer readable medium for determining the thickness of a range shifter to attain target dose coverage in ion beam treatment, wherein the range shifter is for use in a machine for radiation treatment of a target volume, by: receiving, in a processor, input parameters comprising a radiation energy parameter, a range shifter material parameter, object geometry information, and beam characteristic parameters; and further calculating, for each of at least one delivery direction, a range shifter thickness, based on the input parameters, which will deliver the optimum dose conformity.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: November 24, 2020
    Assignee: RaySearch Laboratories AB
    Inventors: Martha Hultqvist, Terese Nordström
  • Patent number: 10842454
    Abstract: A radiation suite includes a room having a floor, a ceiling, and one or more walls, a radiation system including a gantry enclosing a radiation source and a couch, and an image projection system operable to project an image on a projection surface on at least a portion of the gantry and/or the couch, providing a calming environment for a patient to relax. The image projection system comprises a computer and one or more projectors operably controlled by the computer. The computer comprises a mapping software operable to map an image file to the projection surface. The one or more projectors are operable to project the mapped image file on the projection surface.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: November 24, 2020
    Assignee: Varian Medical Systems, Inc.
    Inventors: Rachel Rieger, Nitin Mangi, Roberto Luevano, Ross Hannibal
  • Patent number: 10835762
    Abstract: A medical apparatus according to an embodiment includes an acquirer, an identifier, and a controller. The acquirer acquires a fluoroscopic image of an object from an imager which performs imaging by irradiating the object with an electromagnetic wave to generate the fluoroscopic image. The identifier identifies a target position of the object in the fluoroscopic image. The controller outputs an irradiation permission signal to a therapeutic device which irradiates the object with a therapeutic beam in a case where the target position identified by the identifier is settled within an irradiation permission range.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: November 17, 2020
    Assignee: Toshiba Energy Systems & Solutions Corporation
    Inventors: Shinichiro Mori, Koki Yanagawa, Ryusuke Hirai, Shinya Fukushima, Yasushi Iseki, Keiko Okaya
  • Patent number: 10828508
    Abstract: Methods, apparatus and systems for detecting collision are provided. In one aspect, a method includes: obtaining a first model by performing modelling based on an exterior shape of a first component in the target system, the first component being a movable component, obtaining a second model by performing modelling based on an exterior shape of a second component in the target system, the second component being different from the first component, determining a spatial position of the first model and a spatial position of the second model according to a movement process of the first component at each of detection timings, and for each of the detection timings, determining whether the first component collides with the second component according to the spatial position of the first model, the spatial position of the second model, and a collision condition.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: November 10, 2020
    Assignee: Shanghai Neusoft Medical Technology Co., Ltd.
    Inventors: Long Xu, Dong Wang, Wenda Qin