Radioactive Substance Placed Within Body (e.g., Inhaled, Implanted, Injected, Etc.) Patents (Class 600/3)
  • Patent number: 10300245
    Abstract: The present application relates to applicators and methods for administering therapeutic agents to cancerous tissue. The applicators can be used to deliver radiation and additional therapeutic agents to cancerous tissue located in a subject.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: May 28, 2019
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., University of South Florida
    Inventors: Steven E. Finkelstein, Matthew C. Biagioli, Mayer N. Fishman
  • Patent number: 10286227
    Abstract: Devices and techniques for permanent application of radioactive sources in the field of brachytherapy are described. In an embodiment, an implantable device for radiation therapy of pathological tissues directed toward the administration of radiation to tissue adjacent a cavity wall or surgical excision. The device may include an insertable member, such as a substantially cylindrical member, having at least two ends, a central section positioned between the ends, and a fixation element to retain the implantable device implanted in tissue at a desired position. The device may further include a radioactive source at least partially positioned within the insertable member and that is disposed to deliver radiation to a desired area.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: May 14, 2019
    Assignee: Spec Med Intellectual Property, LLC
    Inventors: John J. Munro, III, Matthew R. Hollows
  • Patent number: 10286197
    Abstract: The present invention offers an alternative for cancer treatment where radiation, thermotherapy, or another therapeutic modality must be delivered to an internal cavity of a subject, for example to treat mouth, anal, cervical, and vaginal cancers. The invention is a new approach that builds on recent results in 3D printing and steerable needle motion planning to create customized implants containing customized curvature-constrained internal channels that fit securely, minimize air gaps, and precisely guide treatment sources through internal printed channels to accurately reach tumors and minimize damage to healthy tissue.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: May 14, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jean Pouliot, Ken Goldberg, I-Chow Hsu, J. Adam M. Cunha, Animesh Garg, Sachin Patil, Pieter Abbeel, Timmy Siauw
  • Patent number: 10271973
    Abstract: A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall. Focal elevating elements and/or other features, such as anchors, can be used to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the endoluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: April 30, 2019
    Assignee: Intact Vascular, Inc.
    Inventors: Robert Giasolli, Peter Schneider
  • Patent number: 10276274
    Abstract: Containers for sealing and shielding radioactive fluid are disclosed. Methods of manufacturing such containers are also disclosed. The container is arranged to maintain a fluid tight seal to contain radioactive fluid when subjected to environmental forces, while also permitting a user to manually remove the cap from the container body when desired. In some embodiments, the container includes a container body with an inner chamber, along with an associated cap. The cap forms a fluid tight seal with the body by way of an interference fit between a sealing element and a burnished abutment surface.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: April 30, 2019
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Joseph Haepers, Ralph Farella
  • Patent number: 10245447
    Abstract: The invention provides for a medical apparatus (200, 300, 400) comprising: a magnetic resonance imaging system (202), a display (270), a processor (228), and a memory (234) for storing instructions for the processor. The instructions causes the processor to receive a brachytherapy treatment plan (240), acquire (100) planning magnetic resonance data (244), calculate (102) a catheter placement positions (246, 900, 902) and a catheter control commands (248) the brachytherapy catheters.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: April 2, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Thomas Erik Amthor, Falk Uhlemann, Sascha Krueger, Steffen Weiss, Ronaldus Frederik Johannes Holthuizen, Daniel Wirtz, Peter Koken
  • Patent number: 10231625
    Abstract: Systems and methods are provided for a catheter-based system of image-guided internally-administered treatment of medical conditions such as, for example, pancreatic cancer. A distal end of a catheter is positioned at a target site inside a patient's body. An imaging probe extended through the catheter collects image data of patient tissue at the target site. The image data is processed and a treatment plan is developed. A radiation source positioned at the distal end of the catheter without removing the catheter. In this way, images collected at the target tissue site can be used to develop a treatment plan and to guide the localized positioning and operation of a treatment device at the same internal tissue site—thereby providing higher resolution imaging than external-based imaging modalities and reduced exposure to radiation as compared to externally applied radiation therapies.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: March 19, 2019
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: Lanchun Lu, Zhilin Hu
  • Patent number: 10232010
    Abstract: The present invention relates to an immunostimulant and to the use of an immunostimulant in the form of a cross-linked muramyl dipeptide microparticle in the treatment of radiation exposure, radiation poisoning, and mitigating the toxic effects of radiotherapy.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: March 19, 2019
    Assignee: Innate Immunotherapeutics Limited
    Inventors: Frank B. Gelder, Gillian Alison Webster
  • Patent number: 10213335
    Abstract: Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: February 26, 2019
    Assignee: Channel Medsystems, Inc.
    Inventors: Daniel R. Burnett, Brian M. Neil, William W. Malecki, Kathleen M. Koch, Gregory J. Lee
  • Patent number: 10201716
    Abstract: Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: February 12, 2019
    Assignee: CIANNA MEDICAL, INC.
    Inventors: George D. Hermann, Eduardo Chi Sing, Gail S. Lebovic, Mark A. Cole, Mark A. Ritchart, Than Nguyen
  • Patent number: 10188515
    Abstract: Devices, systems, and methods for crimping a medical device are disclosed. More specifically, the present disclosure relates to devices, systems, and methods for reducing the diameter of a collapsible heart valve prosthesis to be loaded onto a delivery device. The devices, systems, and methods using at least one funnel to crimp the heart valve prosthesis and load it onto the delivery system.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: January 29, 2019
    Assignee: MEDTRONIC VASCULAR INC.
    Inventors: Niall Duffy, Marian Creaven, Philip Haarstad, Frank Harewood, Igor Kovalsky, Jason Quill, Daniel Gelfman, Ana Menk, Darren Janzig, Shyam Gokaldas, Kenneth Warnock
  • Patent number: 10182868
    Abstract: Electromagnetic transponders as markers are used to localize and guide orthopedic procedures including: knee replacement, hip replacement, shoulder replacement, damaged bone reconstruction, and spine surgery, and more particularly, to guide orthopedic surgical navigation and alignment techniques and instruments. For example, the marker could further be used in any number of guides or templates that attach to the bony anatomy; such as a surgical guide, cutting guide, cutting jig, resection block and/or resurfacing guide. Further, the marker could be incorporated into an existing intramedullary guide rod for a femur and an extramedullary guide rod for a tibia in a knee replacement surgery; or into an external surgical guide system, or the marker could eliminate the need for an external template altogether. According to yet another anticipated use of the tracking system, the marker could be used in conjunction with or replace an optical alignment system.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: January 22, 2019
    Assignee: VARIAN MEDICAL SYSTEMS, INC.
    Inventors: Eric Meier, Steven C. Dimmer, J. Nelson Wright, Rich Edelson
  • Patent number: 10166005
    Abstract: The disclosure provides medical devices comprising improved coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: January 1, 2019
    Assignee: Encapson B.V.
    Inventors: Dennis Manuel Vriezema, Lee Ayres, David Asrian, Johannes Antonius Opsteen
  • Patent number: 10166118
    Abstract: An assembly tool for assembly of a first component of a prosthesis to a second component of the prosthesis for use in joint arthroplasty. The tool includes a first member operably associated with the first component and a second member operably associated with the second component. The second member includes a cap having a threaded recess and further includes a threaded rod adapted to engage the threaded recess so as to move the second member relative to the first member and the threaded rod is made of a harder metal than the threaded recess.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: January 1, 2019
    Assignee: DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Jeffrey A. McAnelly, Rodney E. Satterthwaite, Daniel E. Lashure
  • Patent number: 10159850
    Abstract: A surgical implant is provided comprising a biocompatible member configured for securement to an underlying target surgical site and a radiation source integrated into or onto the biocompatible member. The surgical implant may be one of a clip, pin, or coil and the radiation source includes at least one brachytherapy capsule, or other radioactive material incorporated therein or provided thereon. The radioactive material provides a dose of radiation to the target surgical site. The surgical implant may also be formed from titanium, stainless steel or polymers. A surgical applier is provided for allowing a surgeon to apply the implant to a patient's tissue.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: December 25, 2018
    Assignee: Covidien LP
    Inventors: David Racenet, Gerald Hodgkinson, Abhinav Kachru
  • Patent number: 10143852
    Abstract: The invention relates to a determination apparatus for determining the pose and shape of an introduction element like a catheter within a living being, wherein the introduction element is adapted to be used by a brachytherapy apparatus for introducing a radiation source close to a target object to be treated. A position determination element like guidewire with an electromagnetic tracking element is introduced into the introduction element such that it is arranged at different locations within the introduction element, wherein the positions of the position determination element within the introduction element are determined. The determined positions are then acquired depending on the determined positions for determining the pose and shape of the introduction element within the living being. This can lead to a determination procedure with reduced user interaction, thereby simplifying the determination procedure for the user.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: December 4, 2018
    Assignee: Koninklijke Philips N.V.
    Inventors: Shyam Bharat, Ehsan Dehghan Marvast, Jochen Kruecker, Cynthia Ming-fu Kung
  • Patent number: 10136953
    Abstract: A computer assisted surgery apparatus includes a surgical instrument having an intervention member to cut tissue of a body part of a patient; a control unit arranged to control position and orientation of the intervention member in relation to the body part with regard to a predefined osteotomic line on the body part; and a tracking device arranged to track a position and orientation of the body part. The surgical instrument includes an optical monitoring system mounted in relation to the intervention member, wherein the optical monitoring system is arranged to continuously detect positions of marks applied to the body part, and the control unit is arranged to adjust position and/or orientation of the intervention member when a predefined deviation of the positions of the marks is detected. The surgery apparatus allows for application of cuts in the body part at comparably complex cutting geometries and at comparably high precision.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: November 27, 2018
    Assignee: Advanced Osteotomy Tools—AOT AG
    Inventors: Philippe Cattin, Mathias Griessen, Adrian Schneider, Alfredo Bruno
  • Patent number: 10130371
    Abstract: Embodiments of aortic occlusion devices are described herein that include radially expandable and collapsible proximal and distal end portions, such as annular self-expanding stents or frames, that are configured to radially expand within an aorta to secure the device within the aorta. The devices can also include a catheter extending axially between the distal end portion and the proximal end portion and a porous covering, or filter, positioned around the catheter and between the proximal end portion and the distal end portion and configured to filter emboli from blood flowing into upper-body arteries. The device can further include a one-way valve positioned at or adjacent to the distal end portion of the device and configured to restrict retrograde blood flow through the device toward the heart.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: November 20, 2018
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Mark Dehdashtian, Teodoro S. Jimenez, Nathan Satter, Fabian D. Schroeder, Raffaele Mazzei, Jeff Kosmoski, Shaun Zamani, Adam Yestrepsky
  • Patent number: 10092775
    Abstract: The invention provides for a medical instrument (400, 500, 600, 700) comprising a magnetic resonance imaging system (404) and an external beam radiotherapy system (402) for irradiating a target zone (438) of a subject with a beam (442) of ionizing radiation within the imaging zone. The medical instrument further comprises a processor (448) for controlling the medical instrument. Execution of instructions cause the processor to: acquire (100, 200) first magnetic resonance data (458); reconstruct (102, 202) a first magnetic resonance image (460) from the first magnetic resonance data; receive (104, 204) planning data (462), wherein the planning data specifies a spatially dependent radiation dose for the target zone; register (106, 206) the planning data to the first magnetic resonance image; and calculate (108, 208) an external beam dosage plan (468) and a brachytherapy dosage plan (468) using the spatially dependent radiation dose and the first magnetic resonance image.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: October 9, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Falk Uhlemann, Johannes Overweg
  • Patent number: 10046176
    Abstract: A system for radiotherapy includes an accelerator of an electron beam, an imaging apparatus, a control unit and a radiation dose sensor connected to the control unit equipped with a program configured to execute the steps: setting a first intensity of the electron beam, according to a predefined image of a target zone, the intensity to be emitted in a first radiation; operating said accelerator to emit the first radiation being a fraction of the first intensity; detecting a real intensity during the first radiation by the radiation dose sensor; acquiring an image of the zone; calculating an intermediate intensity according to the image acquired in the step and according to the real intensity; and comparing the first intensity with the intermediate intensity to calculate a final beam intensity for a subsequent second radiation.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: August 14, 2018
    Assignee: ISTITUTI FISIOTERAPICI OSPITALIERI
    Inventors: Marcello Benassi, Lidia Strigari, Sandro Carpino, Marco D'Andrea, Antonella Soriani, Giuseppe Iaccarino
  • Patent number: 10028821
    Abstract: A device for implantation into the heart of a mammal and a method for treating tricuspid regurgitation using the device. The device includes two tubular stent members separated by a stent graft member which has a functional stented valve member attached thereto allowing unidirectional blood flow from the vena cava into the right atrium.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: July 24, 2018
    Assignee: NVT AG
    Inventors: Marcos Centola, Emilia Kawa, Thomas Bogenschuetz
  • Patent number: 10022560
    Abstract: An automated treatment planning system having a planning image memory which stores a volume diagnostic image; a user interface device configured for a user to input data defining a plurality of regions of interest within the volume diagnostic image; and one or more processors. The processors are configured to receive the volume diagnostic image and plurality of user-defined regions of interest indicated within the volume diagnostic image; map the plurality of regions of interest to the body atlas to determine anatomical locations within the plurality of regions of interest; map each region of interest of the plurality of regions of interest to the body atlas to select correct corresponding anatomical structures; receive a treatment plan template based upon the anatomical structures from a knowledge base. A planning module is configured to generate a treatment plan using the treatment plan template.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: July 17, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Prashant Kumar, Karl Antonin Bzdusek
  • Patent number: 10016619
    Abstract: Systems and methods are provided for treating cervical and/or uterine cancers in brachytherapy with an intracavitary brachytherapy applicator. The system comprises a tandem adapted for insertion into a cervix of a patient. An ovoid assembly comprises first and second inflatable ovoids and an ovoid support mechanism. The first and second inflatable ovoids are adapted for insertion within fornices of a patient. First and second retractors are adapted to be coupled to the ovoid assembly. The first retractor is adapted to be positioned to retract the bladder of a patient during treatment. The second retractor is adapted to be positioned to retract the rectum of a patient during treatment. The tandem and the first and second inflatable ovoids are adapted to be coupled to a radioactive source to deliver an implant radiation dose suitable for cancer treatment at a cancerous cervical treatment site in a patient.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: July 10, 2018
    Assignee: Voxel Rad, Ltd.
    Inventor: Javad Rahimian
  • Patent number: 9937280
    Abstract: Luminal prostheses comprise scaffolds having coatings adhered to at least a portion of their outer surfaces. The surfaces are modified to enhance binding of the coatings. For example, the surfaces may be microblasted, laser treated, chemically etched, exposed to plasma, or exposed to a corona discharge, allowing a polymeric coating to adhere to the scaffold more tightly than in the absence of the surface modification. The coatings can be used to deliver therapeutic or other agents dispersed therein.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: April 10, 2018
    Assignee: Elixir Medical Corporation
    Inventors: John Yan, Howard Huang, Vinayak D. Bhat
  • Patent number: 9895517
    Abstract: An inflatable structure for use in biological lumens and methods of making and using the same are disclosed. The structure can have an inflatable balloon encircled by a shell. The shell can have proximal and distal tapered necks, longitudinally-oriented flutes, and apertures at the proximal and distal ends of the shell. The apertures can be recessed in the flutes in the necks. The shell can also have fiber reinforced walls.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: February 20, 2018
    Assignee: LOMA VISTA MEDICAL, INC.
    Inventors: Alexander Q. Tilson, Paul J. Dreyer, Mitchell C. Barham, Mark C. Scheeff, Charles S. Love, Garrett J. Gomes, Jonathan Kurniawan
  • Patent number: 9873001
    Abstract: Methods and devices for minimally-invasive delivery of radiation to the eye (such as the posterior portion of the eye) including cannula systems with multiple treatment positions and/or multiple channels in the distal tip of the cannula systems. The channels can accommodate emanating sources and exposing a target at various treatment positions. The emanating sources may be annulus-shaped.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: January 23, 2018
    Assignee: Salutaris Medical Devices, Inc.
    Inventors: Wendell Lutz, Russell J. Hamilton, Thomas C. Cetas, Laurence J. Marsteller, Timothy Shriver, Samuel S. Hyman
  • Patent number: 9861694
    Abstract: The present invention relates to the use of epidermal growth factor receptor (EGFR) antagonists in methods and compositions useful for the treatment of heart disease in a subject. In one embodiment, the methods of the present invention comprise: (a) administering to the subject an EGFR antagonist; and (b) inhibiting or substantially inhibiting the EGFR signal transduction cascade. In another embodiment the method of the present invention may be used in combination with another heart disease therapy.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: January 9, 2018
    Inventors: Qingping Feng, Xiangru Lu
  • Patent number: 9860455
    Abstract: An object information acquiring apparatus comprising: a receiver configured to receive an acoustic wave propagating from an object; a distribution acquiring unit configured to acquire a distribution of object information by acquiring pieces of object information relative to respective positions in an object from a received acoustic wave; a resolution information acquiring unit configured to acquire a distribution of resolution information that is based on pieces of resolution information of object information relative to each of the positions; and an intensity correction processor configured to correct an intensity of each piece of object information included in a distribution of object information on the basis of a distribution of resolution information.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: January 2, 2018
    Assignee: CANON KABUSHIKI KAISHA
    Inventor: Kohtaro Umezawa
  • Patent number: 9839772
    Abstract: The present embodiments provide apparatus and methods suitable for delivering a therapeutic agent to a target site. The apparatus generally comprises at least one container for holding a therapeutic agent, and a pressure source for facilitating delivery of the therapeutic agent. In one embodiment, the pressure source may be placed in selective fluid communication with a proximal region of the container and fluid from the pressure source may flow through at least a portion of the container to urge the therapeutic agent through container towards the target site. In an alternative embodiment, the container and the pressure source may be coupled to first and second inlet ports of a connecting member, respectively, such that the therapeutic agent flows through an outlet port of the connecting member and towards the target site.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: December 12, 2017
    Assignee: COOK MEDICAL TECHNOLOGIES LLC
    Inventor: Richard W. Ducharme
  • Patent number: 9833310
    Abstract: Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The medical device can include a composite cover formed of a deposited metallic film. The cover may include one or more filaments, e.g., wires, which cooperate with the film to provide desirable mechanical properties. The wires may be integrated with the film by depositing the film over the wires.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: December 5, 2017
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Masoud Molaei, Beren W. Correa
  • Patent number: 9775638
    Abstract: Braces to reduce bending of a brachytherapy needle during insertion into a patient, as well as methods of using the needle braces and kits useful therefor.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: October 3, 2017
    Assignee: MEDI-PHYSICS, INC.
    Inventors: Robert F. Chisholm, Jay Reed, Kevin Helle
  • Patent number: 9763660
    Abstract: An instrument used for brachytherapy delivery in the treatment of cancer by radiation therapy including a handle having first and second handle actuators; an end effector; and an instrument shaft that connects the handle with the end effector. The end effector has first and second adjacent disposed staple cartridges that each retain a set of staples. The first mechanism is for holding standard staples in a first array, and dispensing the standard staples under control of the corresponding first handle actuator. The second mechanism is for holding radioactive source staples in a second array, and dispensing said radioactive source staples under control of the corresponding second handle actuator. The actuating device is removably attachable to an actuator arm on a proximal end. A staple applicator cartridge holder is attached to the actuator arm on a distal end. The staple applicator cartridge is mountable in the holder and having a plurality of slots for mounting of radioactive source staples therein.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: September 19, 2017
    Assignee: Pointsource Technologies, LLC
    Inventors: David E. Wazer, Thomas A. DiPetrillo
  • Patent number: 9763779
    Abstract: A system for implanting a heart valve includes a radially self-expandable tubular body having an inflow end and an outflow end, a decorrelation portion, and a preformed groove disposed at an outer surface of the tubular body between the decorrelation portion and the outflow end. The preformed groove extends at least partially around the tubular body, and has a circumferential opening facing radially outward of the tubular body. A valve is disposed within and attached to the tubular body. The decorrelation portion is configured to dissociate axial and radial movements between the inflow end of the tubular body and the outflow end of the tubular body.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: September 19, 2017
    Assignee: HIGHLIFE SAS
    Inventors: Georg Börtlein, Malek Nasr
  • Patent number: 9750954
    Abstract: A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic, ferromagnetic, or ferrimagnetic properties.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: September 5, 2017
    Assignee: The University of Toledo
    Inventors: E. Ishmael Parsai, Diana Shvydka, Gregory Warrell
  • Patent number: 9743996
    Abstract: A robotic system for flexible needle steering under ultrasound imaging. A robot is used to steer the needle along a predetermined curved trajectory by maneuvering the needle base. The needle tip position is detected by an ultrasound sensor and the tracking error of the needle tip from a predetermined needle path is input to a controller which solves the inverse kinematic based on the needle position, and the needle and tissue properties. The control algorithm uses a novel method to detect the elastic properties of the tissue by analyzing tissue motion at the region in front of the needle tip. The inverse kinematic solution may be performed on a model of the needle as a flexible beam having laterally connected virtual springs to simulate lateral forces exerted by the tissue elasticity. The system is able to direct the needle to a target within the tissue while circumventing forbidden regions.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: August 29, 2017
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: Zipi Neubach, Moshe Shoham
  • Patent number: 9737729
    Abstract: Embodiments of the present disclosure relate to a modular applicator for enabling a brachytherapy treatment, comprising a central core and an outer sleeve, wherein the central core is adapted with a fixation mechanism for affixing the outer sleeve to the central core, wherein the outer sleeve is manufactured from a substantially rigid or shapeable material.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: August 22, 2017
    Assignee: Nucletron Operations B.V.
    Inventors: Wilhelmus Petrus Martinus Maria van Erp, Tommy Robert Oscar Martens, Gaetan Stephan Marie van Wijck, Cor van de Wardt
  • Patent number: 9727998
    Abstract: An apparatus and a method determine a virtual spatial reconstruction of a surgical tool imaged in a 2D x-ray image. A reconstruction module segments a 2D image of at least one element of the surgical tool in the 2D x-ray image and a spatial reconstruction of the at least one element is implemented after the spatial configuration of the 2D image of the at least one element is determined.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: August 8, 2017
    Assignee: Siemens Healthcare GmbH
    Inventor: Rainer Graumann
  • Patent number: 9694201
    Abstract: A method of radio-ablation in conjunction with embolic implants used for pre-embolization of branch arteries in radio-ablation of the liver or other diseased tissue.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: July 4, 2017
    Assignee: Covidien LP
    Inventors: Brian M. Strauss, Jeffrey J. Valko
  • Patent number: 9681852
    Abstract: The disclosure provides medical devices comprising improved coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: June 20, 2017
    Assignee: Encapson B.V.
    Inventors: Dennis Manuel Vriezema, Lee Ayres, David Asrian, Johannes Antonius Opsteen
  • Patent number: 9682251
    Abstract: Devices and techniques for permanent application of radioactive sources in the field of brachytherapy are described. In an embodiment, an implantable device for radiation therapy of pathological tissues directed toward the administration of radiation to tissue adjacent a cavity wall or surgical excision. The device may include an insertable member, such as a substantially cylindrical member, having at least two ends, a central section positioned between the ends, and a fixation element to retain the implantable device implanted in tissue at a desired position. The device may further include a radioactive source at least partially positioned within the insertable member and that is disposed to deliver radiation to a desired area.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: June 20, 2017
    Assignee: SPEC MED Intellectual Property, LLC
    Inventors: John J. Munro, III, Matthew R. Hollows
  • Patent number: 9636523
    Abstract: A system, method and device for brachytherapy treatment verification is described herein. The verification may be in real time and may provide verification of one or more of dose, source position, dwell time and source activity. In one embodiment the invention provides a method for verifying a brachytherapy radiation treatment including processing a distribution of exposure to a brachytherapy radiation source of a two dimensional imaging array to determine a region of high exposure; obtaining one or more distribution of exposure profiles through the region of high exposure; determining a region of high value in the one or more distribution of exposure profiles; and using the determined region of high exposure and/or high value to calculate one or more brachytherapy radiation source position and/or one or more brachytherapy radiation source distance to thereby verify at least a part of the brachytherapy radiation treatment.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: May 2, 2017
    Inventors: Ryan Lee Smith, Rick Don Franich
  • Patent number: 9629574
    Abstract: A base station identifies user-wearable devices being worn by a user, wherein each of the user-wearable devices is battery powered, includes a plurality of sensors, performs wirelessly communication, and is worn on a separate portion of the user's body. For each of the user-wearable devices, the base station identifies a portion of the user's body on which the user-wearable device is being worn. The base station also identifies an activity in which the user is engaged, and identifies multiple types of sensor data to be sensed using the sensors of the user-wearable devices, to enable tracking of metric(s) relevant to the activity in which the user is engaged. The base station determines how to distribute sensing responsibilities for the multiple types of sensor data among the sensors of the user-wearable devices being worn by the user, and selectively activates and deactivates individual sensors of each of the user-wearable devices.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: April 25, 2017
    Assignee: SALUTRON INC.
    Inventor: Yong Jin Lee
  • Patent number: 9603735
    Abstract: A device for use in bariatric surgery includes a tube member, a coupling member, and a rod member. The tube member includes a proximal portion and a distal portion having a distal end. The coupling member is affixed to the tube member. The rod member includes a proximal portion and a distal portion having a distal end. The rod member is slidably coupled with the coupling member. The distal end of the rod member is fixedly coupled to the distal end of the tube member. The proximal portion of the rod member is translatable relative to the tube member to transition the distal portion of the rod member between a contracted position, wherein the distal portion of the rod member extends along the distal portion of the tube member, and a deployed position, wherein the distal portion of the rod member bows outwardly relative to the tube member.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: March 28, 2017
    Assignee: Covidien LP
    Inventor: Amit Trivedi
  • Patent number: 9579524
    Abstract: A flexible, multi-lumen brachytherapy device includes a plurality of loose lumens extend through a hub towards a single point of attachment at a distal rigid section. Because the lumens are attached at only a single distal location, the lumens are free to move axially and rotatably, thereby increasing the overall flexibility of the device to thereby decrease intermittent device movement while increasing patient comfort. A novel keyed stylet can be selectively inserted to increase the rigidity of the device as needed. The ability to dynamically modify the rigidity of the brachytherapy device provides a comprehensive brachytherapy solution that satisfies concerns of the patient, the surgeon and the radiologists.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: February 28, 2017
    Assignee: Hologic, Inc.
    Inventor: John Damarati
  • Patent number: 9579057
    Abstract: Apparatus and associated methods relate to method of determining a treatment plan with Botulinum Toxin (BT) and other procedures able to modify facial expressions, the method includes using a series of facial images of a patient eliciting various expressions to select individual expressive features as candidates for modification, the selected expressive features mapping to muscles that are used to create such expressive features, the muscles mapping into related expressive features of facial images of the patient eliciting different expressions, the related expressive features being weighted so as to provide further information used in determining an optimum treatment dosing for each treatment location. In an illustrative example, the method may include mapping the facial image of the patient to a model image using facial markers. In an exemplary embodiment, the method may advantageously provide a treatment that results in optimum expressive features as revealed in many different expressions.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: February 28, 2017
    Inventor: Stefan Bradu
  • Patent number: 9561080
    Abstract: An apparatus for providing at least one treatment to at least one tissue having a first structural arrangement configured to expand a first portion at a distal end of the apparatus, a second structural arrangement configured to expand a second portion at the distal end and at least one lumen associated with at least one of the first structural arrangement and/or the second structural arrangement. The first structural arrangement and/or the second structural arrangement can be configured to position the at least one lumen at a particular position with respect to the tissue. A tip is configured to aid in the insertion of the apparatus into the tissue(s).
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: February 7, 2017
    Assignees: Memorial Sloan-Kettering Cancer Center, GC Medtech LLC
    Inventors: Gary A. Lamoureux, Gil'Ad N. Cohen, Karyn Goodman
  • Patent number: 9554117
    Abstract: A system for non-invasive registration between a patient and a three-dimensional (3D) medical image includes a near infrared 3D camera 110 which extracts a 3D blood vessel image I2 of a patients registration target area during surgical operation; a camera position tracer 120 which traces a position of the near infrared 3D camera 110 and calculates a real world coordinate system of the 3D blood vessel image I2; a controller 130 which extracts a first blood vessel pattern from a 3D medical image I1 of the registration target area, extracts a second blood vessel pattern from the 3D blood vessel image I2, and performs position registration between the patient and the 3D medical image I1 through the extracted first and second blood vessel patterns; and a display 140 which displays a registration result calculated by the controller 130.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: January 24, 2017
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Deukhee Lee, Se Hyung Park, Sunghwan Lim
  • Patent number: 9539372
    Abstract: We describe herein biocompatible single crystal Cu-based shape memory alloys (SMAs). In particular, we show biocompatibility based on MEM elution cell cytotoxicity, ISO intramuscular implant, and hemo-compatibility tests producing negative cytotoxic results. This biocompatibility may be attributed to the formation of a durable oxide surface layer analogous to the titanium oxide layer that inhibits body fluid reaction to titanium nickel alloys, and/or the non-existence of crystal domain boundaries may inhibit corrosive chemical attack. Methods for controlling the formation of the protective aluminum oxide layer are also described, as are devices including such biocompatible single crystal copper-based SMAs.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: January 10, 2017
    Assignee: Ormco Corporation
    Inventor: Alfred David Johnson
  • Patent number: 9498644
    Abstract: A double-balloon brachytherapy catheter includes an outer-balloon that is filled with a liquid substance or air via an outer-balloon-filler. Further, an inner-balloon is filled with a liquid substance or air via an inner-balloon-filler, with the inner-balloon inserted inside the outer-balloon. Additionally, a plurality of radiation-tubes is positioned in association within the inner-balloon, such as to an outside border of the inner-balloon and within the outer-balloon. Each radiation-tube out of the plurality is segmented into segments of differing hardness. In addition, a vacuum-tube can be wrapped around an exterior of the outer-balloon, where the vacuum tube is used to remove fluids and air to create a void. Also, the plurality of radiation-tubes can be configured to run longitudinally along a central shaft of the double-balloon brachytherapy catheter.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: November 22, 2016
    Assignee: Best Medical International, Inc.
    Inventor: Lloyd Michael Cutrer
  • Patent number: 9492683
    Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: November 15, 2016
    Assignee: GammaTile LLC
    Inventors: David Brachman, Peter Nakaji, Heyoung McBride, Emad Youssef, Theresa Thomas