Radioactive Substance Placed Within Body (e.g., Inhaled, Implanted, Injected, Etc.) Patents (Class 600/3)
  • Patent number: 10773099
    Abstract: A material for brachytherapy is provided comprising a substrate having a longitudinal axis and a latitudinal, wherein the substrate comprises alternating peaks and valleys which are parallel to the longitudinal axis, the alternating peaks and valleys defining latitudinally extending pleats; and a plurality of medicament moieties positioned on the peaks and valleys of the substrate.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: September 15, 2020
    Inventor: Arnold M. Herskovic
  • Patent number: 10773100
    Abstract: Methods and devices are disclosed for treating a patient with an unruptured saccular aneurysm that is not associated with an arteriovenous malformation, wherein ionizing radiation is delivered to the brain of a patient through stereotactic radiosurgery. The radiosurgery may be performed with a Gamma Knife stereotactic radiosurgery apparatus, LINAC device such as CYBERKNIFE® stereotactic radiosurgery apparatus, or particle-beam device. The treatment impedes a natural progression of the aneurysm towards rupture and may actually obliterate the aneurysm. The treatment plan may be based in part on measured geometric properties of the aneurysm or on physical aneurysm properties such as permeability, wall thickness, wall motion, the presence of macrophages, shear stress, and flow velocities. The methods may be used in conjunction with endovascular coil embolization.
    Type: Grant
    Filed: July 29, 2017
    Date of Patent: September 15, 2020
    Inventor: John D. Lipani
  • Patent number: 10758193
    Abstract: The invention relates to a medical radiation protector, which is configured in such a way that said radiation protector holds tumor tissue and adjoining healthy tissue in a clear relative position with respect to each other in the head-and-neck region during a radiation treatment for cancer therapy, and which comprises at least a lower jaw element, an upper jaw element, and optionally a tissue protection element, and which is produced partially from a plastic that can be used in an additive method and that is approved for use in/against/on a human or animal body for medical purposes, wherein the part produced from said plastic is produced by means of an additive production method. The invention further relates to a production method for said radiation protector, to a system for performing the method, and to a computer program that substantially controls the method.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: September 1, 2020
    Inventor: Remo Bettega
  • Patent number: 10709901
    Abstract: A fastener applicator includes a body portion including a handle assembly, a cartridge assembly supported within the body portion, the cartridge assembly including implantable fasteners, a drive assembly supported within the body portion and operatively coupled to the cartridge assembly to engage the implantable fasteners, and an actuation assembly supported within the handle assembly and operatively coupled to the drive assembly to fire a distal-most implantable fastener upon actuation of the actuation assembly. At least one of the implantable fasteners includes a body including a tissue facing surface, a tissue penetrating portion extending from the body, and a capsule affixed to the tissue facing surface of the body, the capsule including radioactive material.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: July 14, 2020
    Assignee: Covidien LP
    Inventors: Stanislaw Kostrzewski, Gerald Hodgkinson, Lee Ann Olson, Russell Pribanic, Matthew Chowaniec, Robert Pedros, Thomas Campanelli, David Nicholas
  • Patent number: 10702307
    Abstract: A multi-cannula surgical instrument (1), having an inner cannula (3) movably disposed within an outer cannula (2), the inner cannula (3) having a blunt distal tip (3b), one or more first inner ducts (31) and one or more first flow-through orifices (32) arranged to allow one or more fluid flows therethrough, where the inner and the outer cannula (2, 3) at the proximal ends (2a, 3a) thereof are mounted onto a hub (4) that includes a biasing mechanism (43) coupled to the inner cannula (3) and arranged to bias the inner cannula (3) automatically from a retracted towards an advanced position in case of absence of resistance against the inner cannula (3), where the outer cannula (2) has one or more second flow-through orifices (22) that are in fluid communication with one or more second ducts (21) arranged between the outer and the inner cannula (2, 3), where the second flow-through orifices (22), the hub (4) and the second duct(s) (21) are configured to allow at least one fluid flow therethrough.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: July 7, 2020
    Assignee: Vesalius Medical Technologies BVBA
    Inventor: Kristoffel Pieter Maria Mulier
  • Patent number: 10688316
    Abstract: To provide patient shielding of non-treatment areas bordering a treatment zone of the patient during radiation therapy, a shield device may be located on the patient. The shield device has a plurality of interconnected and overlapping elements, e.g. in a scale maille arrangement, that forms a conformal sheet that can be laid over the shielded portion of the patient, e.g. over the contralateral breast during breast cancer treatment. The edge of the scale maille sheet is substantially configurable and can be made to conform to the field edge of the treatment zone on the patient.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: June 23, 2020
    Inventor: Macinley Butson
  • Patent number: 10685451
    Abstract: An image registration method includes acquiring first image data for a target object that includes first coordinate information; acquiring second image data for the target object that includes second coordinate information, by using a probe; and registering the first image data with the second image data, using the first coordinate information and the second coordinate information. According to the image registration method, image registration between a plurality of pieces of volume data adjusted so that their coordinate axes correspond to each other is performed, whereby a high-quality registered image may be quickly and simply obtained.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: June 16, 2020
    Inventors: Dong-kuk Shin, Bong-koo Seo, Sung-jin Choi
  • Patent number: 10674973
    Abstract: One aspect of the invention provides a system for radiation treatment of a tumor allowing for imaging of the tumor and a surrounding region during radiation therapy and to methods of using such a system. In one embodiment, the system includes a number of radiation detectors positioned in an array to detect radiation scattered from the tumor and the surrounding region. A 3-dimensional image of the tumor is reconstructed from the 2-dimensional scattered radiation projections.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: June 9, 2020
    Assignees: Rush University Medical Center, UChicago Argonne, LLC
    Inventors: James Chu, William F. Sensakovic, Damian Bernard, Gage Redler, Steve Wang
  • Patent number: 10650532
    Abstract: A phase correlation method (PCM) can be used for translational and/or rotational alignment of 3D medical images even in the presence of non-rigid deformations between first and second images of a registered volume of a patient.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: May 12, 2020
    Inventors: Georgi Gerganov, Iwan Kawrykow
  • Patent number: 10646724
    Abstract: A brachytherapy device includes a bioabsorbable support and a plurality of microcapsules on the support. Each of the plurality of the microcapsules includes a plurality of microspheres and a bioabsorbable microcapsule wall that encloses the plurality of microspheres. The plurality of microspheres includes radiation-emitting microspheres comprising a radioactive material, radio-opaque microspheres comprising a radio-opaque material or a combination thereof.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: May 12, 2020
    Assignee: Civatech Oncology
    Inventors: Seth A. Hoedl, Bruce Kitzman
  • Patent number: 10646727
    Abstract: Aspects herein are directed to an anchorable brachytherapy device configured to be permanently implanted in a tumor bed at the time of operative removal of the tumor. In exemplary aspects, the brachytherapy device may comprise a plurality of hollow tubes that form a spherical or ellipsoid shape. Protrusions or grooves may be formed on an outer surface of the tubes to help anchor the brachytherapy device in the tumor bed. Radioactive seeds or strands may be positioned within the tube channels to provide radiation to the tumor bed.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: May 12, 2020
    Assignee: Positive Energy, LLC
    Inventor: Ibrahim Abdalla
  • Patent number: 10603463
    Abstract: Individual wake-up alarm patch. In some embodiments, a wearable patch can include a patch substrate configured to support a plurality of components, and to allow the patch to be attached to a skin of a user. The wearable patch can further include an alert component implemented at least partially within the patch substrate and configured to alert the user based on an alarm control signal. The wearable patch can further include a receiver circuit in communication with the alert component and configured to receive the alarm control signal and induce the alerting of the user by the alert component.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: March 31, 2020
    Inventor: Donald Bollella
  • Patent number: 10607743
    Abstract: The disclosure pertains to a radiation source, typically containing low-density microbeads of iridium or compounds thereof within an encapsulation, and methods of manufacture thereof.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: March 31, 2020
    Assignee: QSA GLOBAL, INC.
    Inventors: Mark W. Vose, Mark G. Shilton, Robert Brosofsky
  • Patent number: 10568687
    Abstract: A multimodal medical device for the diagnosis and/or thermal treatment of a disease includes an instrument for performing thermal therapy; and an imaging system having multiple tomographic imaging modes, including optical coherence tomography (OCT), ultrasound imaging, photoacoustic (PA) imaging, fluorescence imaging and/or thermal imaging to provide guidance for accurate diagnosis and treatment of the disease.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: February 25, 2020
    Assignees: The Regents of the University of California, Med-X institute Shanghai Jiao Tong University
    Inventors: Zhongping Chen, Gangjun Liu, Jiawen Li, Lisa X. Xu, Aili Zhang
  • Patent number: 10556046
    Abstract: A bone marrow aspiration device and associated method includes an introducer needle assembly and an aspiration needle assembly. The introducer needle assembly includes an introducer cannula having proximal and distal ends, each end including an opening, and a screw assembly coupled to the introducer handle. The screw assembly includes a threaded tube and a lead screw receivable in the threaded tube. An outer cover is disposed around and in sealing engagement with the threaded tube and the lead screw. The aspiration needle assembly is receivable in the introducer cannula and includes an aspiration cannula forming a channel for aspirating bone marrow and including a flexible portion that extends from a distal end along a length of the aspiration cannula. A length of the aspiration cannula that extends beyond the distal end of the introducer cannula is adjustable by advancing the lead screw into or reversing the lead screw out of the threaded tube.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: February 11, 2020
    Assignee: EndoCellutions, Inc.
    Inventors: Andrew McGillicuddy, Andy H. Levine
  • Patent number: 10548631
    Abstract: An example introducer is disclosed. An example introducer includes an inner liner including a lumen, a distal region and at least one folded portion extending along the distal region. The introducer also includes a reinforcing member having a length and including at least one spine extending along the length of the reinforcing member. The introducer also includes a sheath disposed along at least a portion of the introducer, wherein the sheath includes at least one perforation, wherein material adjacent to the at least one folded portion is removed from a distal portion of the introducer to form a tip region. The introducer also includes a tip member disposed along the tip region.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: February 4, 2020
    Assignee: Boston Scientific Scimed Inc.
    Inventors: Mimi Trinh Fitterer, Takashi H. Ino, Randy S. Gamarra, Floriza Q. Escalona, Frederick J. Serrahsu, James M. Anderson, Adam D. Grovender
  • Patent number: 10543379
    Abstract: This disclosure provides design, material, manufacturing method, and use alternatives for medical devices. An example medical device includes a stent having a first strut. The first strut may include an inner surface and an outer surface. The medical device may also include a first attachment member coupled to the strut and a radioactive element. The radioactive element may be coupled to the attachment member.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: January 28, 2020
    Inventors: John A. Hingston, Claude O. Clerc, Daniel Ross
  • Patent number: 10471234
    Abstract: A catheter apparatus may have a flexible shaft, guidewire lumens passing through the shaft, and a positioning device for positioning the guidewires relative to an external lumen. The positioning device may be an expansible scaffold covered with a retractable sheath. The positioning device may also be one or more balloons that are inflated through an inflation port in the shaft. The catheter apparatus may be operated by inserting a guide catheter into a vasculature with a chronic total occlusion, inserting the catheter apparatus into the guide catheter, and advancing the guidewires through the guidewire lumens and into contact with a chronic total occlusion. The positioning device may be activated before and/or between attempts to pass the guidewires through the chronic total occlusion to interrogate various parts of the chronic total occlusion.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: November 12, 2019
    Inventor: Mark Taber
  • Patent number: 10456468
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: October 29, 2019
    Assignee: NuvOx Pharma LLC
    Inventor: Evan C. Unger
  • Patent number: 10456212
    Abstract: The present disclosure relates generally to precise stereotactic implantation of an instrument (e.g., a recording electrode, a stimulating electrode, a biopsy instrument, a catheter, a delivery device, and the like) into a target area in a patient's brain. As such, one aspect of the present disclosure can relate to a stereotactic device that can be used to accomplish the precise implantation of the instrument. The stereotactic device can include a body to secure the stereotactic device to the patient's head. In some instances, the body can have a u-shape. The stereotactic device can also include a guide attached between sides of the body to move an instrument holder into place above a target area. The guide can be locked in position to lock the instrument holder in the place to facilitate injection of the instrument into the target area.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: October 29, 2019
    Inventors: Jorge A. Gonzalez-Martinez, John Gale, Anthony Shawan
  • Patent number: 10456595
    Abstract: A system for interventional brachytherapy for generating data to be used directly for therapy and/or for therapy planning includes a radiation source which irradiates tissue of a patient and one or more radiation detectors which detect radiation delivered to the patient and generate radiation dosage data indicative thereof. One or more position sensors determine the position of the radiation source and a localization unit, in communication with the one or more position sensors, generates position data indicative of the position of the radiation source. An image database stores one or more anatomical images of the patient. A dose calculation unit which co-registers the one or more anatomical images with the positional and radiation dosage data and generates dose monitoring data based on the co-registration.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: October 29, 2019
    Inventors: Carolina Ribbing, Raymond Chan, Luis Felipe Gutierrez
  • Patent number: 10448994
    Abstract: A method for manufacturing a shaping structure having a generally helical profile and configured to support electrodes for delivering electric energy into a cylindrical lumen of a patient. The method comprises providing a mandrel with a circular cylindrical shape and forming a first hole in the mandrel along the elongate axis, such that opposing ends of a bore of the first hole emerge at the proximal end and at the distal end; forming a second hole in the mandrel to extend from the curved surface to connect with the first hole; wrapping a metal wire around the mandrel; and inserting opposing ends of the metal wire into the second and the third hole respectively, and threading the opposing ends of the metal wire until they emerge from the opposing ends of the bore of the first hole; finally, heating the mandrel and the wire.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: October 22, 2019
    Inventors: Benjamyn Serna, Jesus Magana, Michael Ngo, John Stankus
  • Patent number: 10420732
    Abstract: The present invention relates to the design and development of a drug delivery nanoplatform that consists of nanoporous, multi-layer biodegradable polymeric (BP) thin films for controlled release of its payload. The method is used notably to synthesize nanoporous BP coatings as drug delivery vehicles exhibiting uniform nanopores with tailored characteristics for control of drug delivery and release. It enables the multiplex delivery of drugs that can be eluted at desirable time intervals in line with each medical need. Atomic Force Microscopy and Spectroscopic Ellipsometry are applied for determining nanoporosity, thickness, drug loading, structural properties, and quality of the BP films ensuring the quality control of the final product. The complete degradation of the polymers minimizes the toxicity within the human body and such nanoplatform can be used in a wide range of drug eluting and other medical implants and biomedical devices.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: September 24, 2019
    Assignees: Aristotle University of Thessaloniki-Research Committee
    Inventors: Stergios Logothetidis, Varvara Karagkiozaki
  • Patent number: 10413750
    Abstract: The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: September 17, 2019
    Assignee: HOLOGIC, INC.
    Inventors: Paul Lubock, Michael L. Jones, Frank R. Louw
  • Patent number: 10413381
    Abstract: An implantable tissue marker device is provided to be placed in a soft tissue site through a surgical incision. The device can include a bioabsorbable body in the form of a spiral and defining a spheroid shape for the device, the spiral having a longitudinal axis, and turns of the spiral being spaced apart from each other in a direction along the longitudinal axis. A plurality of markers can be disposed on the body, the markers being visualizable by a radiographic imaging device. The turns of the spiral are sufficiently spaced apart to form gaps that allow soft tissue to infiltrate between the turns and to allow flexibility in the device along the longitudinal axis in the manner of a spring.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: September 17, 2019
    Inventors: George D. Hermann, David B. Willis, Michael J. Drews, Gail S. Lebovic, James B. Stubbs
  • Patent number: 10413318
    Abstract: Various embodiments of devices and systems comprising a polymer driveshaft for use in high-speed rotational medical procedures, e.g., atherectomy, are disclosed. Generally, the primary driveshaft for transferring torque and activating rotation of a tool attached thereto, e.g., an abrasive element, is constructed with at least a polymer outer and inner surface. In certain embodiments, the polymer driveshaft may comprise a metallic band for fixed attachment of a structure, e.g., an abrasive element, thereto. Various embodiments may comprise a coupler that connects a drive shaft connected with a prime mover, e.g., a turbine or electric motor, with the polymer drive shaft, the coupler comprising openings through the coupler wall to the inner diameter of the coupler to allow fluid flow to the inner diameter of the coupled polymer drive shaft.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: September 17, 2019
    Assignee: Cardiovascular Systems, Inc.
    Inventors: Preston L. Grothe, Matthew D. Cambronne, Joseph P. Higgins, William F. Kuester, III, Benjamin Haselman, Joshua J. Cranston, Ric A. Gould, Nicholas W. Rydberg
  • Patent number: 10391186
    Abstract: The present invention is directed to improved methods for generating compositions comprising actinium-225.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: August 27, 2019
    Assignee: Triad National Security, LLC
    Inventors: Eva Rachel Birnbaum, Jonathan W. Engle, Francois Meiring Nortier
  • Patent number: 10350433
    Abstract: Disclosed is a layer structure for epidermal radionuclide therapy (brachytherapy) of a patient comprising, from a patient's view, a proximal adherent layer for applying the layer structure on the skin surface to be treated of a patient; a flexible, transparent carrier layer that from a patient's view is located in a distal direction on the adherent layer; and at least one radionuclide-containing emission layer located on the carrier layer, the adherent layer and the carrier layer with regard to their components and thickness being formed such that they are essentially transparent for ? and ? radiation. The layer structure is suited particularly for radiotherapeutic treatment of the basal-cell carcinoma (BCC) and the squamous cell carcinoma (SCC). With the aid of the layer structure, geometrically complex skin lesions caused by a tumor, as occurring e.g. on the outer edge of the auricle, may be treated easily.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: July 16, 2019
    Assignee: Oncobeta International GmbH
    Inventors: Maria Desantis, Oliver Buck, Cesidio Cipriani
  • Patent number: 10350431
    Abstract: Carriers for embodying radioactive seeds, as well as a device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present disclosure relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: July 16, 2019
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Patent number: 10346719
    Abstract: The present disclosure provides a magnetic resonance (MR) image analysis method for a patient who underwent radiotherapy. The method includes the steps: receiving an MR image set of a patient and a dose map of a radiotherapy plan; converting the dose intensity distribution of the dose map into the relative spatial positions in the MR image set; selecting a radiation dose and a radiation exposure region, wherein the radiation exposure region has radiation intensity being equal to or higher than the radiation dose; using the radiation exposure region to determine a region of interest (ROI) in the MR image set; classifying the voxels inside the ROI of the MR image set into different clusters according to the grayscale values of the voxels inside the ROI; and calculating the volume or ratios of the different clusters inside the ROI. The present disclosure also provides a method for evaluating risks of radiotherapy.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: July 9, 2019
    Inventors: Syu-Jyun Peng, Cheng-Chia Lee, Huai-Che Yang
  • Patent number: 10335610
    Abstract: The present application relates to a catheter apparatus including a tubular member, and four or more fluid-flow pipe members, each having a proximal end and a distal end, and each being disposed around a periphery of the tubular member along an axial direction thereof. Each of the four or more fluid-flow pipe members is provided with an independent positioning member at the distal end thereof, and the number of positioning members is four or more. A brachytherapy system and a method of reducing area of radiation exposure of normal tissue in a brachytherapy treatment using the catheter apparatus are also disclosed.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: July 2, 2019
    Assignee: BRAXX BIOTECH CO., LTD
    Inventors: Kai-Lin Yang, Hsuan-Mien Wang, Wei-Jer Chang
  • Patent number: 10300245
    Abstract: The present application relates to applicators and methods for administering therapeutic agents to cancerous tissue. The applicators can be used to deliver radiation and additional therapeutic agents to cancerous tissue located in a subject.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: May 28, 2019
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., University of South Florida
    Inventors: Steven E. Finkelstein, Matthew C. Biagioli, Mayer N. Fishman
  • Patent number: 10286227
    Abstract: Devices and techniques for permanent application of radioactive sources in the field of brachytherapy are described. In an embodiment, an implantable device for radiation therapy of pathological tissues directed toward the administration of radiation to tissue adjacent a cavity wall or surgical excision. The device may include an insertable member, such as a substantially cylindrical member, having at least two ends, a central section positioned between the ends, and a fixation element to retain the implantable device implanted in tissue at a desired position. The device may further include a radioactive source at least partially positioned within the insertable member and that is disposed to deliver radiation to a desired area.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: May 14, 2019
    Assignee: Spec Med Intellectual Property, LLC
    Inventors: John J. Munro, III, Matthew R. Hollows
  • Patent number: 10286197
    Abstract: The present invention offers an alternative for cancer treatment where radiation, thermotherapy, or another therapeutic modality must be delivered to an internal cavity of a subject, for example to treat mouth, anal, cervical, and vaginal cancers. The invention is a new approach that builds on recent results in 3D printing and steerable needle motion planning to create customized implants containing customized curvature-constrained internal channels that fit securely, minimize air gaps, and precisely guide treatment sources through internal printed channels to accurately reach tumors and minimize damage to healthy tissue.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: May 14, 2019
    Inventors: Jean Pouliot, Ken Goldberg, I-Chow Hsu, J. Adam M. Cunha, Animesh Garg, Sachin Patil, Pieter Abbeel, Timmy Siauw
  • Patent number: 10271973
    Abstract: A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall. Focal elevating elements and/or other features, such as anchors, can be used to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the endoluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: April 30, 2019
    Assignee: Intact Vascular, Inc.
    Inventors: Robert Giasolli, Peter Schneider
  • Patent number: 10276274
    Abstract: Containers for sealing and shielding radioactive fluid are disclosed. Methods of manufacturing such containers are also disclosed. The container is arranged to maintain a fluid tight seal to contain radioactive fluid when subjected to environmental forces, while also permitting a user to manually remove the cap from the container body when desired. In some embodiments, the container includes a container body with an inner chamber, along with an associated cap. The cap forms a fluid tight seal with the body by way of an interference fit between a sealing element and a burnished abutment surface.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: April 30, 2019
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Joseph Haepers, Ralph Farella
  • Patent number: 10245447
    Abstract: The invention provides for a medical apparatus (200, 300, 400) comprising: a magnetic resonance imaging system (202), a display (270), a processor (228), and a memory (234) for storing instructions for the processor. The instructions causes the processor to receive a brachytherapy treatment plan (240), acquire (100) planning magnetic resonance data (244), calculate (102) a catheter placement positions (246, 900, 902) and a catheter control commands (248) the brachytherapy catheters.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: April 2, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Thomas Erik Amthor, Falk Uhlemann, Sascha Krueger, Steffen Weiss, Ronaldus Frederik Johannes Holthuizen, Daniel Wirtz, Peter Koken
  • Patent number: 10231625
    Abstract: Systems and methods are provided for a catheter-based system of image-guided internally-administered treatment of medical conditions such as, for example, pancreatic cancer. A distal end of a catheter is positioned at a target site inside a patient's body. An imaging probe extended through the catheter collects image data of patient tissue at the target site. The image data is processed and a treatment plan is developed. A radiation source positioned at the distal end of the catheter without removing the catheter. In this way, images collected at the target tissue site can be used to develop a treatment plan and to guide the localized positioning and operation of a treatment device at the same internal tissue site—thereby providing higher resolution imaging than external-based imaging modalities and reduced exposure to radiation as compared to externally applied radiation therapies.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: March 19, 2019
    Inventors: Lanchun Lu, Zhilin Hu
  • Patent number: 10232010
    Abstract: The present invention relates to an immunostimulant and to the use of an immunostimulant in the form of a cross-linked muramyl dipeptide microparticle in the treatment of radiation exposure, radiation poisoning, and mitigating the toxic effects of radiotherapy.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: March 19, 2019
    Assignee: Innate Immunotherapeutics Limited
    Inventors: Frank B. Gelder, Gillian Alison Webster
  • Patent number: 10213335
    Abstract: Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure and temperature sensing elements which may allow for control of the pressure and temperature within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled, room temperature, or warmed fluid such as water may then be used to rapidly terminate the treatment session.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: February 26, 2019
    Assignee: Channel Medsystems, Inc.
    Inventors: Daniel R. Burnett, Brian M. Neil, William W. Malecki, Kathleen M. Koch, Gregory J. Lee
  • Patent number: 10201716
    Abstract: Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: February 12, 2019
    Assignee: CIANNA MEDICAL, INC.
    Inventors: George D. Hermann, Eduardo Chi Sing, Gail S. Lebovic, Mark A. Cole, Mark A. Ritchart, Than Nguyen
  • Patent number: 10188515
    Abstract: Devices, systems, and methods for crimping a medical device are disclosed. More specifically, the present disclosure relates to devices, systems, and methods for reducing the diameter of a collapsible heart valve prosthesis to be loaded onto a delivery device. The devices, systems, and methods using at least one funnel to crimp the heart valve prosthesis and load it onto the delivery system.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: January 29, 2019
    Inventors: Niall Duffy, Marian Creaven, Philip Haarstad, Frank Harewood, Igor Kovalsky, Jason Quill, Daniel Gelfman, Ana Menk, Darren Janzig, Shyam Gokaldas, Kenneth Warnock
  • Patent number: 10182868
    Abstract: Electromagnetic transponders as markers are used to localize and guide orthopedic procedures including: knee replacement, hip replacement, shoulder replacement, damaged bone reconstruction, and spine surgery, and more particularly, to guide orthopedic surgical navigation and alignment techniques and instruments. For example, the marker could further be used in any number of guides or templates that attach to the bony anatomy; such as a surgical guide, cutting guide, cutting jig, resection block and/or resurfacing guide. Further, the marker could be incorporated into an existing intramedullary guide rod for a femur and an extramedullary guide rod for a tibia in a knee replacement surgery; or into an external surgical guide system, or the marker could eliminate the need for an external template altogether. According to yet another anticipated use of the tracking system, the marker could be used in conjunction with or replace an optical alignment system.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: January 22, 2019
    Inventors: Eric Meier, Steven C. Dimmer, J. Nelson Wright, Rich Edelson
  • Patent number: 10166005
    Abstract: The disclosure provides medical devices comprising improved coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: January 1, 2019
    Assignee: Encapson B.V.
    Inventors: Dennis Manuel Vriezema, Lee Ayres, David Asrian, Johannes Antonius Opsteen
  • Patent number: 10166118
    Abstract: An assembly tool for assembly of a first component of a prosthesis to a second component of the prosthesis for use in joint arthroplasty. The tool includes a first member operably associated with the first component and a second member operably associated with the second component. The second member includes a cap having a threaded recess and further includes a threaded rod adapted to engage the threaded recess so as to move the second member relative to the first member and the threaded rod is made of a harder metal than the threaded recess.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: January 1, 2019
    Inventors: Jeffrey A. McAnelly, Rodney E. Satterthwaite, Daniel E. Lashure
  • Patent number: 10159850
    Abstract: A surgical implant is provided comprising a biocompatible member configured for securement to an underlying target surgical site and a radiation source integrated into or onto the biocompatible member. The surgical implant may be one of a clip, pin, or coil and the radiation source includes at least one brachytherapy capsule, or other radioactive material incorporated therein or provided thereon. The radioactive material provides a dose of radiation to the target surgical site. The surgical implant may also be formed from titanium, stainless steel or polymers. A surgical applier is provided for allowing a surgeon to apply the implant to a patient's tissue.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: December 25, 2018
    Assignee: Covidien LP
    Inventors: David Racenet, Gerald Hodgkinson, Abhinav Kachru
  • Patent number: 10143852
    Abstract: The invention relates to a determination apparatus for determining the pose and shape of an introduction element like a catheter within a living being, wherein the introduction element is adapted to be used by a brachytherapy apparatus for introducing a radiation source close to a target object to be treated. A position determination element like guidewire with an electromagnetic tracking element is introduced into the introduction element such that it is arranged at different locations within the introduction element, wherein the positions of the position determination element within the introduction element are determined. The determined positions are then acquired depending on the determined positions for determining the pose and shape of the introduction element within the living being. This can lead to a determination procedure with reduced user interaction, thereby simplifying the determination procedure for the user.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: December 4, 2018
    Assignee: Koninklijke Philips N.V.
    Inventors: Shyam Bharat, Ehsan Dehghan Marvast, Jochen Kruecker, Cynthia Ming-fu Kung
  • Patent number: 10136953
    Abstract: A computer assisted surgery apparatus includes a surgical instrument having an intervention member to cut tissue of a body part of a patient; a control unit arranged to control position and orientation of the intervention member in relation to the body part with regard to a predefined osteotomic line on the body part; and a tracking device arranged to track a position and orientation of the body part. The surgical instrument includes an optical monitoring system mounted in relation to the intervention member, wherein the optical monitoring system is arranged to continuously detect positions of marks applied to the body part, and the control unit is arranged to adjust position and/or orientation of the intervention member when a predefined deviation of the positions of the marks is detected. The surgery apparatus allows for application of cuts in the body part at comparably complex cutting geometries and at comparably high precision.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: November 27, 2018
    Assignee: Advanced Osteotomy Tools—AOT AG
    Inventors: Philippe Cattin, Mathias Griessen, Adrian Schneider, Alfredo Bruno
  • Patent number: 10130371
    Abstract: Embodiments of aortic occlusion devices are described herein that include radially expandable and collapsible proximal and distal end portions, such as annular self-expanding stents or frames, that are configured to radially expand within an aorta to secure the device within the aorta. The devices can also include a catheter extending axially between the distal end portion and the proximal end portion and a porous covering, or filter, positioned around the catheter and between the proximal end portion and the distal end portion and configured to filter emboli from blood flowing into upper-body arteries. The device can further include a one-way valve positioned at or adjacent to the distal end portion of the device and configured to restrict retrograde blood flow through the device toward the heart.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: November 20, 2018
    Inventors: Mark Dehdashtian, Teodoro S. Jimenez, Nathan Satter, Fabian D. Schroeder, Raffaele Mazzei, Jeff Kosmoski, Shaun Zamani, Adam Yestrepsky
  • Patent number: 10092775
    Abstract: The invention provides for a medical instrument (400, 500, 600, 700) comprising a magnetic resonance imaging system (404) and an external beam radiotherapy system (402) for irradiating a target zone (438) of a subject with a beam (442) of ionizing radiation within the imaging zone. The medical instrument further comprises a processor (448) for controlling the medical instrument. Execution of instructions cause the processor to: acquire (100, 200) first magnetic resonance data (458); reconstruct (102, 202) a first magnetic resonance image (460) from the first magnetic resonance data; receive (104, 204) planning data (462), wherein the planning data specifies a spatially dependent radiation dose for the target zone; register (106, 206) the planning data to the first magnetic resonance image; and calculate (108, 208) an external beam dosage plan (468) and a brachytherapy dosage plan (468) using the spatially dependent radiation dose and the first magnetic resonance image.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: October 9, 2018
    Inventors: Falk Uhlemann, Johannes Overweg