Radioactive Substance Placed Within Body (e.g., Inhaled, Implanted, Injected, Etc.) Patents (Class 600/3)
  • Patent number: 11134946
    Abstract: A surgical stapler, cartridge assembly, and related methods are disclosed. A cartridge assembly for a surgical stapler has a first cartridge portion; and a second cartridge portion; wherein each of the first and second cartridge portions has an upper surface for engaging tissue, and a slot to house a staple. A proximal portion of each of the first and second cartridge portions has a guide portion having at least one of a channel or a protrusion for guiding at least a portion of an i-beam. The second cartridge portion is removably couplable to the first cartridge portion to form a channel.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: October 5, 2021
    Assignee: Bolder Surgical, LLC
    Inventors: Richard N. Granger, Allison B. Lyle, Joseph D. Bucciaglia
  • Patent number: 11135323
    Abstract: Provided is a process of producing activated particles comprising 188Re-isotopes and/or 186Re-isotopes by irradiating non-volatile and water-insoluble starting particles comprising a rhenium compound with neutrons. Further provided is a process of producing corresponding non-volatile and water-insoluble starting particles. Further provided are respective starting particles and activated particles, respectively, and a composition comprising a plurality of activated particles. The activated particles, and the composition comprising same are suitable for use in radionuclide therapy, and for cosmetic applications.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 5, 2021
    Inventors: Tuomo Nikula, Thomas Wendler
  • Patent number: 11130004
    Abstract: Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 28, 2021
    Assignee: Cianna Medical, Inc.
    Inventors: George D. Hermann, Eduardo Chi Sing, Gail S. Lebovic, Mark A. Cole, Mark A. Ritchart, Than Nguyen
  • Patent number: 11116992
    Abstract: The disclosure pertains to improvements in a gamma radiation source, typically containing low-density alloys or compounds or composites of iridium in mechanically deformable and compressible configurations, within a sealed encapsulation, and methods of manufacture thereof.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: September 14, 2021
    Assignee: QSA GLOBAL, INC.
    Inventor: Mark Shilton
  • Patent number: 11103264
    Abstract: A clot retrieval device with an elongate shaft and an expandable section, the expandable section having a framework of interconnected strut elements distal of the elongate shaft, the strut elements forming an outer expandable body and an inner expandable body. At least a portion of the strut elements include a first coating of radiopaque material defining a plurality of micro-columns, wherein each micro-column includes a length extending between a first end coupled to one of the plurality of strut elements and a second free end opposite the first end, the length of each micro-column is longer than a width of each micro-column. The second free end is capable of moving further apart when a convex bend is applied to the respective strut element during use. Also including a second coating.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: August 31, 2021
    Inventors: David Vale, Eamon Brady, Michael Gilvarry, David Hardiman, Brendan Casey
  • Patent number: 11058489
    Abstract: Microwave ablation devices and systems and method including the devices are provided. The microwave ablation device includes a cable assembly operably coupled to an energy source, a feedline in electrical communication with the cable assembly, a balun disposed on the feedline, an outer tubular member through which the feedline at least partially extends, and an inflatable barrier disposed on the outer tubular member proximal to the balun.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: July 13, 2021
    Assignee: COVIDIEN LP
    Inventor: Kathy E. Rooks
  • Patent number: 11051842
    Abstract: A tissue-removing catheter for removing tissue in a body lumen includes an elongate body and a tissue-removing element mounted on a distal end portion of the elongate body. The tissue-removing element is configured to remove the tissue as the tissue-removing element is rotated by the elongate body within the body lumen. An inner liner is received within the elongate body and coupled to a handle at a proximal end of the inner liner. The inner liner defines a guidewire lumen. The inner liner isolates an interior of the guidewire lumen from the elongate body and tissue-removing element such that rotational and torsional forces are not transferred from the elongate body and tissue-removing element to the interior of the guidewire lumen when the elongate body and tissue-removing element are rotated during operation of the tissue-removing catheter.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: July 6, 2021
    Inventors: Aram Jamous, John Kelly, Matthew Fleming, Colin William Meade, Grainne Teresa Carroll
  • Patent number: 11045667
    Abstract: Real-time X-ray dosimetry sensing in intraoperative radiation therapy (IORT). According to one aspect, a treatment head comprises at least one X-ray component configured to facilitate generation of therapeutic radiation in the X-ray wavelength range. A resilient balloon is disposed over the treatment head and configured for receiving therein a fluid to facilitate X-ray treatment of a tumor cavity. A plurality of X-ray sensing elements is disposed at a plurality of locations distributed on the interior or exterior of the resilient balloon and configured for sensing X-ray radiation emanating from the treatment head. A control system is provided that is responsive to data received from the X-ray sensing elements to determine a magnitude of X-ray radiation detected at each of the X-ray sensing elements.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: June 29, 2021
    Inventor: Kalman Fishman
  • Patent number: 11020000
    Abstract: A luminescent ophthalmic device for administering therapeutic materials, the device having at least one luminescent marker disposed in proximity to a therapeutic agent applicator so as facilitate placement in a treatment position when viewed using transcorneal or transpupillary viewing methods.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: June 1, 2021
    Inventors: Paul T. Finger, Toby Welles
  • Patent number: 11000392
    Abstract: A crimping method that crimps a stent over multiple catheters. The method includes differentially crimping a stent on certain portions of a balloon catheter so that a second catheter can be threaded through the uncrimped portion of the stent and exit through the links of a conventional stent design or through a specific hole in the stent designed for a branched vessel.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: May 11, 2021
    Assignee: Advanced Bifurcation Systems Inc.
    Inventors: Henry Bourang, Mehran Khorsandi
  • Patent number: 11000370
    Abstract: Implantable devices including conduits that have markings along the length of the conduit are described herein.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: May 11, 2021
    Assignee: PECA Labs, Inc.
    Inventors: C. Douglas Bernstein, Arush Kalra, Denver Faulk
  • Patent number: 10967198
    Abstract: The invention describes method for delivering and positioning radio-isotopes. The method uses encapsulating free flowing medicament into a vehicle and positioning the vehicle into the body. Also provided is a system for delivering and positioning radio-isotopes into the body, the system comprising fluid radio-isotope encapsulated in a material.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: April 6, 2021
    Inventor: Arnold Herskovic
  • Patent number: 10959865
    Abstract: An intracranial stent includes a proximal end, a distal end, and a tubular sidewall extending there between and a patch covering at least a portion of the sidewall; wherein the patch is capable of diverting blood flow past the neck of an intracranial aneurysm. The patch may be made of a photon-activatable material or a tightly woven metal material with a density greater than a density of the sidewall itself.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: March 30, 2021
    Inventor: Jeffrey E. Thomas
  • Patent number: 10952631
    Abstract: A biomagnetism measurement device includes a tubular body, an inflatable portion inflatable upon supply of gas, and a magnetic sensor portion that detects a magnetic field from outside the tubular body. The inflatable portion is located at a required region of the tubular body, and the magnetic sensor portion is fixed to an inner wall of the inflatable portion. The tubular body and the inflatable portion include the same material, and the wall thickness of the inflatable portion is thinner than that of the tubular body.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: March 23, 2021
    Assignees: National University Corporation Tokyo Medical and Dental University, TDK CORPORATION
    Inventors: Shigenori Kawabata, Satoshi Sumiya, Shuichi Okawa
  • Patent number: 10950362
    Abstract: The disclosure pertains to a strontium-90 sealed radiological or radioactive source, such as may be used with treatment of the eye or other medical or industrial processes. The sealed radiological source includes a toroidal shaped strontium radiological insert within an encapsulation. The encapsulation includes increased shielding in the center thereof.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: March 16, 2021
    Assignee: QSA GLOBAL, INC.
    Inventors: Mark W. Vose, Mark G. Shilton, Jason W. Bourn
  • Patent number: 10925727
    Abstract: A medical device delivery system can include a dilator including a tip having a taper in a distal direction, a coupler, and a flap that radially protrudes from the tip. The flap can be configured to bend against a body lumen to cover at least a portion of the delivery system when the dilator is tracked through the body lumen. A medical device delivery system can include a dilator including a tip having a lumen and a coupler having a lumen. The coupler can be configured to securely connect to the tip such that the lumen of the tip is aligned with the lumen of the coupler to allow a guide wire to pass therethrough. Methods for loading a medical device into a delivery catheter are also disclosed.
    Type: Grant
    Filed: January 7, 2018
    Date of Patent: February 23, 2021
    Inventors: Niall Duffy, John Gallagher, Gerry McCaffrey, Noam Miller, Glenn Stante
  • Patent number: 10926105
    Abstract: A surgical implant includes a biocompatible member configured for securement to an underlying target surgical site and a radiation source integrated into or onto the biocompatible member. The surgical implant may be one of a clip, pin, or coil and the radiation source includes at least one brachytherapy capsule, or other radioactive material incorporated therein or provided thereon. The radioactive material provides a dose of radiation to the target surgical site. The surgical implant may also be formed from titanium, stainless steel or polymers. A surgical applier is provided for allowing a surgeon to apply the implant to a patient's tissue.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: February 23, 2021
    Assignee: COVIDIEN LP
    Inventors: David Racenet, Gerald Hodgkinson, Abhinav Kachru
  • Patent number: 10918829
    Abstract: An expandable sheath may include an inelastic compliant membrane having a lumen therethrough, and a discontinuous outer member bonded to the membrane. The membrane may include one or more folds formed therein. At least a portion of the outer member may extend continuously around a circumference of the membrane in a first configuration. The outer member may be configured to separate to a second configuration when subjected to a radially outward force from within the membrane. The outer member may taper from a first diameter adjacent a proximal hub to a second smaller diameter at a distal end. A method of manufacturing an expandable sheath may include forming one or more folds in a compliant membrane, cutting a plurality of apertures through a wall of an outer covering; and laminating the outer covering onto the membrane, wherein the plurality of apertures is disposed over the one or more folds.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: February 16, 2021
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Mimi Trinh Fitterer, Takashi H. Ino, Randy S. Gamarra, Floriza Q. Escalona
  • Patent number: 10869996
    Abstract: An intra-tumoral agent deployment apparatus for diagnosing and delivering targeted, sequential deployment of agents to an endo-bronchial and, or an intra-parenchymal tumor, said apparatus formed of, among other things, an elongated shaft assembly including: at least one lumen; an intra-tumoral probe wire for tumor traversal, slidably interposed there between or slidably disposed between any one of, or combination of the at least one lumen; and wherein the displacement of the intra-tumoral probe wire causes disruption of an endo-bronchial and, or an intra-parenchymal tumor tissue, and, or creating an inlet for deployment of at least a first agent comprising any one of a therapeutic agent and, or a delivery vehicle from the first lumen, and a subsequent second agent comprising any one of a therapeutic agent and, or a binding agent from any one of the first lumen, second lumen, and, or the delivery vehicle.
    Type: Grant
    Filed: October 29, 2016
    Date of Patent: December 22, 2020
    Inventor: Stephen Kuperberg
  • Patent number: 10850118
    Abstract: Methods and devices for minimally-invasive delivery of radiation to the eye (such as the posterior portion of the eye) including cannula systems with multiple treatment positions and/or multiple channels in the distal tip of the cannula systems. The channels can accommodate emanating sources and exposing a target at various treatment positions. The emanating sources may be annulus-shaped.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: December 1, 2020
    Inventors: Wendell Lutz, Russell J. Hamilton, Thomas C. Cetas, Laurence J. Marsteller, Timothy Shriver, Samuel S. Hyman
  • Patent number: 10773100
    Abstract: Methods and devices are disclosed for treating a patient with an unruptured saccular aneurysm that is not associated with an arteriovenous malformation, wherein ionizing radiation is delivered to the brain of a patient through stereotactic radiosurgery. The radiosurgery may be performed with a Gamma Knife stereotactic radiosurgery apparatus, LINAC device such as CYBERKNIFE® stereotactic radiosurgery apparatus, or particle-beam device. The treatment impedes a natural progression of the aneurysm towards rupture and may actually obliterate the aneurysm. The treatment plan may be based in part on measured geometric properties of the aneurysm or on physical aneurysm properties such as permeability, wall thickness, wall motion, the presence of macrophages, shear stress, and flow velocities. The methods may be used in conjunction with endovascular coil embolization.
    Type: Grant
    Filed: July 29, 2017
    Date of Patent: September 15, 2020
    Inventor: John D. Lipani
  • Patent number: 10773099
    Abstract: A material for brachytherapy is provided comprising a substrate having a longitudinal axis and a latitudinal, wherein the substrate comprises alternating peaks and valleys which are parallel to the longitudinal axis, the alternating peaks and valleys defining latitudinally extending pleats; and a plurality of medicament moieties positioned on the peaks and valleys of the substrate.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: September 15, 2020
    Inventor: Arnold M. Herskovic
  • Patent number: 10758193
    Abstract: The invention relates to a medical radiation protector, which is configured in such a way that said radiation protector holds tumor tissue and adjoining healthy tissue in a clear relative position with respect to each other in the head-and-neck region during a radiation treatment for cancer therapy, and which comprises at least a lower jaw element, an upper jaw element, and optionally a tissue protection element, and which is produced partially from a plastic that can be used in an additive method and that is approved for use in/against/on a human or animal body for medical purposes, wherein the part produced from said plastic is produced by means of an additive production method. The invention further relates to a production method for said radiation protector, to a system for performing the method, and to a computer program that substantially controls the method.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: September 1, 2020
    Inventor: Remo Bettega
  • Patent number: 10709901
    Abstract: A fastener applicator includes a body portion including a handle assembly, a cartridge assembly supported within the body portion, the cartridge assembly including implantable fasteners, a drive assembly supported within the body portion and operatively coupled to the cartridge assembly to engage the implantable fasteners, and an actuation assembly supported within the handle assembly and operatively coupled to the drive assembly to fire a distal-most implantable fastener upon actuation of the actuation assembly. At least one of the implantable fasteners includes a body including a tissue facing surface, a tissue penetrating portion extending from the body, and a capsule affixed to the tissue facing surface of the body, the capsule including radioactive material.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: July 14, 2020
    Assignee: Covidien LP
    Inventors: Stanislaw Kostrzewski, Gerald Hodgkinson, Lee Ann Olson, Russell Pribanic, Matthew Chowaniec, Robert Pedros, Thomas Campanelli, David Nicholas
  • Patent number: 10702307
    Abstract: A multi-cannula surgical instrument (1), having an inner cannula (3) movably disposed within an outer cannula (2), the inner cannula (3) having a blunt distal tip (3b), one or more first inner ducts (31) and one or more first flow-through orifices (32) arranged to allow one or more fluid flows therethrough, where the inner and the outer cannula (2, 3) at the proximal ends (2a, 3a) thereof are mounted onto a hub (4) that includes a biasing mechanism (43) coupled to the inner cannula (3) and arranged to bias the inner cannula (3) automatically from a retracted towards an advanced position in case of absence of resistance against the inner cannula (3), where the outer cannula (2) has one or more second flow-through orifices (22) that are in fluid communication with one or more second ducts (21) arranged between the outer and the inner cannula (2, 3), where the second flow-through orifices (22), the hub (4) and the second duct(s) (21) are configured to allow at least one fluid flow therethrough.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: July 7, 2020
    Assignee: Vesalius Medical Technologies BVBA
    Inventor: Kristoffel Pieter Maria Mulier
  • Patent number: 10688316
    Abstract: To provide patient shielding of non-treatment areas bordering a treatment zone of the patient during radiation therapy, a shield device may be located on the patient. The shield device has a plurality of interconnected and overlapping elements, e.g. in a scale maille arrangement, that forms a conformal sheet that can be laid over the shielded portion of the patient, e.g. over the contralateral breast during breast cancer treatment. The edge of the scale maille sheet is substantially configurable and can be made to conform to the field edge of the treatment zone on the patient.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: June 23, 2020
    Inventor: Macinley Butson
  • Patent number: 10685451
    Abstract: An image registration method includes acquiring first image data for a target object that includes first coordinate information; acquiring second image data for the target object that includes second coordinate information, by using a probe; and registering the first image data with the second image data, using the first coordinate information and the second coordinate information. According to the image registration method, image registration between a plurality of pieces of volume data adjusted so that their coordinate axes correspond to each other is performed, whereby a high-quality registered image may be quickly and simply obtained.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: June 16, 2020
    Inventors: Dong-kuk Shin, Bong-koo Seo, Sung-jin Choi
  • Patent number: 10674973
    Abstract: One aspect of the invention provides a system for radiation treatment of a tumor allowing for imaging of the tumor and a surrounding region during radiation therapy and to methods of using such a system. In one embodiment, the system includes a number of radiation detectors positioned in an array to detect radiation scattered from the tumor and the surrounding region. A 3-dimensional image of the tumor is reconstructed from the 2-dimensional scattered radiation projections.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: June 9, 2020
    Assignees: Rush University Medical Center, UChicago Argonne, LLC
    Inventors: James Chu, William F. Sensakovic, Damian Bernard, Gage Redler, Steve Wang
  • Patent number: 10646727
    Abstract: Aspects herein are directed to an anchorable brachytherapy device configured to be permanently implanted in a tumor bed at the time of operative removal of the tumor. In exemplary aspects, the brachytherapy device may comprise a plurality of hollow tubes that form a spherical or ellipsoid shape. Protrusions or grooves may be formed on an outer surface of the tubes to help anchor the brachytherapy device in the tumor bed. Radioactive seeds or strands may be positioned within the tube channels to provide radiation to the tumor bed.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: May 12, 2020
    Assignee: Positive Energy, LLC
    Inventor: Ibrahim Abdalla
  • Patent number: 10646724
    Abstract: A brachytherapy device includes a bioabsorbable support and a plurality of microcapsules on the support. Each of the plurality of the microcapsules includes a plurality of microspheres and a bioabsorbable microcapsule wall that encloses the plurality of microspheres. The plurality of microspheres includes radiation-emitting microspheres comprising a radioactive material, radio-opaque microspheres comprising a radio-opaque material or a combination thereof.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: May 12, 2020
    Assignee: Civatech Oncology
    Inventors: Seth A. Hoedl, Bruce Kitzman
  • Patent number: 10650532
    Abstract: A phase correlation method (PCM) can be used for translational and/or rotational alignment of 3D medical images even in the presence of non-rigid deformations between first and second images of a registered volume of a patient.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: May 12, 2020
    Inventors: Georgi Gerganov, Iwan Kawrykow
  • Patent number: 10607743
    Abstract: The disclosure pertains to a radiation source, typically containing low-density microbeads of iridium or compounds thereof within an encapsulation, and methods of manufacture thereof.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: March 31, 2020
    Assignee: QSA GLOBAL, INC.
    Inventors: Mark W. Vose, Mark G. Shilton, Robert Brosofsky
  • Patent number: 10603463
    Abstract: Individual wake-up alarm patch. In some embodiments, a wearable patch can include a patch substrate configured to support a plurality of components, and to allow the patch to be attached to a skin of a user. The wearable patch can further include an alert component implemented at least partially within the patch substrate and configured to alert the user based on an alarm control signal. The wearable patch can further include a receiver circuit in communication with the alert component and configured to receive the alarm control signal and induce the alerting of the user by the alert component.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: March 31, 2020
    Inventor: Donald Bollella
  • Patent number: 10568687
    Abstract: A multimodal medical device for the diagnosis and/or thermal treatment of a disease includes an instrument for performing thermal therapy; and an imaging system having multiple tomographic imaging modes, including optical coherence tomography (OCT), ultrasound imaging, photoacoustic (PA) imaging, fluorescence imaging and/or thermal imaging to provide guidance for accurate diagnosis and treatment of the disease.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: February 25, 2020
    Assignees: The Regents of the University of California, Med-X institute Shanghai Jiao Tong University
    Inventors: Zhongping Chen, Gangjun Liu, Jiawen Li, Lisa X. Xu, Aili Zhang
  • Patent number: 10556046
    Abstract: A bone marrow aspiration device and associated method includes an introducer needle assembly and an aspiration needle assembly. The introducer needle assembly includes an introducer cannula having proximal and distal ends, each end including an opening, and a screw assembly coupled to the introducer handle. The screw assembly includes a threaded tube and a lead screw receivable in the threaded tube. An outer cover is disposed around and in sealing engagement with the threaded tube and the lead screw. The aspiration needle assembly is receivable in the introducer cannula and includes an aspiration cannula forming a channel for aspirating bone marrow and including a flexible portion that extends from a distal end along a length of the aspiration cannula. A length of the aspiration cannula that extends beyond the distal end of the introducer cannula is adjustable by advancing the lead screw into or reversing the lead screw out of the threaded tube.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: February 11, 2020
    Assignee: EndoCellutions, Inc.
    Inventors: Andrew McGillicuddy, Andy H. Levine
  • Patent number: 10548631
    Abstract: An example introducer is disclosed. An example introducer includes an inner liner including a lumen, a distal region and at least one folded portion extending along the distal region. The introducer also includes a reinforcing member having a length and including at least one spine extending along the length of the reinforcing member. The introducer also includes a sheath disposed along at least a portion of the introducer, wherein the sheath includes at least one perforation, wherein material adjacent to the at least one folded portion is removed from a distal portion of the introducer to form a tip region. The introducer also includes a tip member disposed along the tip region.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: February 4, 2020
    Assignee: Boston Scientific Scimed Inc.
    Inventors: Mimi Trinh Fitterer, Takashi H. Ino, Randy S. Gamarra, Floriza Q. Escalona, Frederick J. Serrahsu, James M. Anderson, Adam D. Grovender
  • Patent number: 10543379
    Abstract: This disclosure provides design, material, manufacturing method, and use alternatives for medical devices. An example medical device includes a stent having a first strut. The first strut may include an inner surface and an outer surface. The medical device may also include a first attachment member coupled to the strut and a radioactive element. The radioactive element may be coupled to the attachment member.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: January 28, 2020
    Inventors: John A. Hingston, Claude O. Clerc, Daniel Ross
  • Patent number: 10471234
    Abstract: A catheter apparatus may have a flexible shaft, guidewire lumens passing through the shaft, and a positioning device for positioning the guidewires relative to an external lumen. The positioning device may be an expansible scaffold covered with a retractable sheath. The positioning device may also be one or more balloons that are inflated through an inflation port in the shaft. The catheter apparatus may be operated by inserting a guide catheter into a vasculature with a chronic total occlusion, inserting the catheter apparatus into the guide catheter, and advancing the guidewires through the guidewire lumens and into contact with a chronic total occlusion. The positioning device may be activated before and/or between attempts to pass the guidewires through the chronic total occlusion to interrogate various parts of the chronic total occlusion.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: November 12, 2019
    Inventor: Mark Taber
  • Patent number: 10456212
    Abstract: The present disclosure relates generally to precise stereotactic implantation of an instrument (e.g., a recording electrode, a stimulating electrode, a biopsy instrument, a catheter, a delivery device, and the like) into a target area in a patient's brain. As such, one aspect of the present disclosure can relate to a stereotactic device that can be used to accomplish the precise implantation of the instrument. The stereotactic device can include a body to secure the stereotactic device to the patient's head. In some instances, the body can have a u-shape. The stereotactic device can also include a guide attached between sides of the body to move an instrument holder into place above a target area. The guide can be locked in position to lock the instrument holder in the place to facilitate injection of the instrument into the target area.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: October 29, 2019
    Inventors: Jorge A. Gonzalez-Martinez, John Gale, Anthony Shawan
  • Patent number: 10456468
    Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: October 29, 2019
    Assignee: NuvOx Pharma LLC
    Inventor: Evan C. Unger
  • Patent number: 10456595
    Abstract: A system for interventional brachytherapy for generating data to be used directly for therapy and/or for therapy planning includes a radiation source which irradiates tissue of a patient and one or more radiation detectors which detect radiation delivered to the patient and generate radiation dosage data indicative thereof. One or more position sensors determine the position of the radiation source and a localization unit, in communication with the one or more position sensors, generates position data indicative of the position of the radiation source. An image database stores one or more anatomical images of the patient. A dose calculation unit which co-registers the one or more anatomical images with the positional and radiation dosage data and generates dose monitoring data based on the co-registration.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: October 29, 2019
    Inventors: Carolina Ribbing, Raymond Chan, Luis Felipe Gutierrez
  • Patent number: 10448994
    Abstract: A method for manufacturing a shaping structure having a generally helical profile and configured to support electrodes for delivering electric energy into a cylindrical lumen of a patient. The method comprises providing a mandrel with a circular cylindrical shape and forming a first hole in the mandrel along the elongate axis, such that opposing ends of a bore of the first hole emerge at the proximal end and at the distal end; forming a second hole in the mandrel to extend from the curved surface to connect with the first hole; wrapping a metal wire around the mandrel; and inserting opposing ends of the metal wire into the second and the third hole respectively, and threading the opposing ends of the metal wire until they emerge from the opposing ends of the bore of the first hole; finally, heating the mandrel and the wire.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: October 22, 2019
    Inventors: Benjamyn Serna, Jesus Magana, Michael Ngo, John Stankus
  • Patent number: 10420732
    Abstract: The present invention relates to the design and development of a drug delivery nanoplatform that consists of nanoporous, multi-layer biodegradable polymeric (BP) thin films for controlled release of its payload. The method is used notably to synthesize nanoporous BP coatings as drug delivery vehicles exhibiting uniform nanopores with tailored characteristics for control of drug delivery and release. It enables the multiplex delivery of drugs that can be eluted at desirable time intervals in line with each medical need. Atomic Force Microscopy and Spectroscopic Ellipsometry are applied for determining nanoporosity, thickness, drug loading, structural properties, and quality of the BP films ensuring the quality control of the final product. The complete degradation of the polymers minimizes the toxicity within the human body and such nanoplatform can be used in a wide range of drug eluting and other medical implants and biomedical devices.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: September 24, 2019
    Assignees: Aristotle University of Thessaloniki-Research Committee
    Inventors: Stergios Logothetidis, Varvara Karagkiozaki
  • Patent number: 10413750
    Abstract: The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: September 17, 2019
    Assignee: HOLOGIC, INC.
    Inventors: Paul Lubock, Michael L. Jones, Frank R. Louw
  • Patent number: 10413381
    Abstract: An implantable tissue marker device is provided to be placed in a soft tissue site through a surgical incision. The device can include a bioabsorbable body in the form of a spiral and defining a spheroid shape for the device, the spiral having a longitudinal axis, and turns of the spiral being spaced apart from each other in a direction along the longitudinal axis. A plurality of markers can be disposed on the body, the markers being visualizable by a radiographic imaging device. The turns of the spiral are sufficiently spaced apart to form gaps that allow soft tissue to infiltrate between the turns and to allow flexibility in the device along the longitudinal axis in the manner of a spring.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: September 17, 2019
    Inventors: George D. Hermann, David B. Willis, Michael J. Drews, Gail S. Lebovic, James B. Stubbs
  • Patent number: 10413318
    Abstract: Various embodiments of devices and systems comprising a polymer driveshaft for use in high-speed rotational medical procedures, e.g., atherectomy, are disclosed. Generally, the primary driveshaft for transferring torque and activating rotation of a tool attached thereto, e.g., an abrasive element, is constructed with at least a polymer outer and inner surface. In certain embodiments, the polymer driveshaft may comprise a metallic band for fixed attachment of a structure, e.g., an abrasive element, thereto. Various embodiments may comprise a coupler that connects a drive shaft connected with a prime mover, e.g., a turbine or electric motor, with the polymer drive shaft, the coupler comprising openings through the coupler wall to the inner diameter of the coupler to allow fluid flow to the inner diameter of the coupled polymer drive shaft.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: September 17, 2019
    Assignee: Cardiovascular Systems, Inc.
    Inventors: Preston L. Grothe, Matthew D. Cambronne, Joseph P. Higgins, William F. Kuester, III, Benjamin Haselman, Joshua J. Cranston, Ric A. Gould, Nicholas W. Rydberg
  • Patent number: 10391186
    Abstract: The present invention is directed to improved methods for generating compositions comprising actinium-225.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: August 27, 2019
    Assignee: Triad National Security, LLC
    Inventors: Eva Rachel Birnbaum, Jonathan W. Engle, Francois Meiring Nortier
  • Patent number: 10350433
    Abstract: Disclosed is a layer structure for epidermal radionuclide therapy (brachytherapy) of a patient comprising, from a patient's view, a proximal adherent layer for applying the layer structure on the skin surface to be treated of a patient; a flexible, transparent carrier layer that from a patient's view is located in a distal direction on the adherent layer; and at least one radionuclide-containing emission layer located on the carrier layer, the adherent layer and the carrier layer with regard to their components and thickness being formed such that they are essentially transparent for ? and ? radiation. The layer structure is suited particularly for radiotherapeutic treatment of the basal-cell carcinoma (BCC) and the squamous cell carcinoma (SCC). With the aid of the layer structure, geometrically complex skin lesions caused by a tumor, as occurring e.g. on the outer edge of the auricle, may be treated easily.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: July 16, 2019
    Assignee: Oncobeta International GmbH
    Inventors: Maria Desantis, Oliver Buck, Cesidio Cipriani
  • Patent number: 10350431
    Abstract: Carriers for embodying radioactive seeds, as well as a device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present disclosure relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: July 16, 2019
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Patent number: 10346719
    Abstract: The present disclosure provides a magnetic resonance (MR) image analysis method for a patient who underwent radiotherapy. The method includes the steps: receiving an MR image set of a patient and a dose map of a radiotherapy plan; converting the dose intensity distribution of the dose map into the relative spatial positions in the MR image set; selecting a radiation dose and a radiation exposure region, wherein the radiation exposure region has radiation intensity being equal to or higher than the radiation dose; using the radiation exposure region to determine a region of interest (ROI) in the MR image set; classifying the voxels inside the ROI of the MR image set into different clusters according to the grayscale values of the voxels inside the ROI; and calculating the volume or ratios of the different clusters inside the ROI. The present disclosure also provides a method for evaluating risks of radiotherapy.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: July 9, 2019
    Inventors: Syu-Jyun Peng, Cheng-Chia Lee, Huai-Che Yang