Radioactive Substance Placed Within Body (e.g., Inhaled, Implanted, Injected, Etc.) Patents (Class 600/3)
  • Patent number: 11590358
    Abstract: A catheter is disclosed for performing ultraviolet light therapy in a pulmonary system of a patient, which includes a catheter body having opposed proximal and distal end portions, a handle assembly operatively associated with the proximal end portion of the catheter body, an illumination assembly operatively associated with the distal end portion of the catheter body and including an LED light source for generating UVC radiation, wherein the illumination assembly includes a coupler connecting the LED light source with the distal end portion of the catheter body, and an elongated braided sleeve disposed within the catheter body, wherein the coupler is adapted to transfer heat from the illumination assembly to the braided sleeve, such that the braided sleeve serves as a heat sink for the illumination assembly.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: February 28, 2023
    Assignee: Osypka Technologies LLC
    Inventors: Thomas P. Osypka, Timothy Searfoss, N R Chandrasekar
  • Patent number: 11534191
    Abstract: A loading device for loading a medical device into a catheter is provided. The loading device comprises a body having a lumen to receive an expandable portion of a medical device. The lumen has a length as the expandable portion when the latter is in a collapsed configuration and has a diameter that is greater than the collapsed configuration. The body comprises a first portion and a second portion that are reversibly separable to expose the lumen in an open configuration and enclose the lumen in a closed configuration. The first and second portions each comprise an inner face having a groove defining a first portion of the lumen and a second portion of the lumen, respectively. The body also has a distal tip portion to reversibly couple with a hemostatic valve of a delivery catheter. A method of loading a medical device into a catheter is also provided.
    Type: Grant
    Filed: December 24, 2019
    Date of Patent: December 27, 2022
    Assignee: Anaconda Biomed, S.L.
    Inventors: Robert Ros Fàbrega, Iñaki Galve Murillo, Ofir Arad Hadar, Ane Lizarazu Gonzalez
  • Patent number: 11529201
    Abstract: Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: December 20, 2022
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Jack Mondry, Shane Farritor, Eric Markvicka, Thomas Frederick, Joe Bartels
  • Patent number: 11529432
    Abstract: Described embodiments include an apparatus (20, 21), which includes a support (22), including an outer surface (24) and configured for insertion into a body of a subject. The apparatus further includes multiple atoms (26) of a radionuclide, which radioactively decays to produce a daughter radionuclide, coupled to the outer surface, and a layer (28, 33) of a polymer, which is permeable to the daughter radionuclide, that covers the atoms. Other embodiments are also described.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: December 20, 2022
    Assignee: ALPHA TAU MEDICAL LTD.
    Inventors: Itzhak Kelson, Yona Keisari, Michael Schmidt, Avia Berkowitz
  • Patent number: 11524176
    Abstract: A locator for the placement of a fiducial support device for brachytherapy may be used to perform a brachytherapy treatment in which one or more radioactive seeds are implanted into a treatment region of a patient.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: December 13, 2022
    Assignee: COWLES VENTURES, LLC
    Inventors: Alvaro Martinez, Mary Ann Slavik, Emily Lin
  • Patent number: 11484355
    Abstract: An inflatable bone tamp including a first balloon portion and a second balloon portion is provided. Each of the first balloon portion and the second balloon portion include interior cavities that can be filled with liquid, and these interior cavities communicate with one another via a valve. The valve can limit or restrict flow of the liquid between the cavities. As such, the first balloon portion and the second balloon portion can be sequentially inflated with the liquid through use of the valve.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: November 1, 2022
    Assignee: MEDTRONIC HOLDING COMPANY SÀRL
    Inventors: Calin Druma, Asha Sharma
  • Patent number: 11478620
    Abstract: A multi-purpose balloon intra-cavity catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction opening associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: October 25, 2022
    Assignee: Best Medical International, Inc.
    Inventor: Manny R. Subramanian
  • Patent number: 11446515
    Abstract: An apparatus for providing treatment to at least one tissue includes a distal balloon, a proximal balloon, and at least one intermediate balloon positioned between the distal balloon and the proximal balloon and inflatable independently from the distal and proximal balloons. A source lumen is positioned within at least the intermediate balloon receives a radiation source to treat target tissue adjacent the intermediate balloon.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: September 20, 2022
    Inventors: Gary Lamoureux, Juan-Carlos Diaz, Gil'ad Cohen
  • Patent number: 11406800
    Abstract: A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction point associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: August 9, 2022
    Assignee: Best Medical International, Inc.
    Inventor: Manny R. Subramanian
  • Patent number: 11388799
    Abstract: A phototherapy system includes a channel driver, a first microcontroller and a pad comprising a string of light-emitting diodes (LEDs). The pad also comprises a second microcontroller that autonomously controls the string of LEDs such that the LEDs are controlled even if communication between the first microcontroller and the pad is interrupted.
    Type: Grant
    Filed: April 6, 2019
    Date of Patent: July 12, 2022
    Assignee: Applied BioPhotonics Ltd.
    Inventors: Richard K. Williams, Keng-Hung Lin, Laura E. Williams
  • Patent number: 11364370
    Abstract: A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction point associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: June 21, 2022
    Assignee: Best Medical International, Inc.
    Inventor: Manny R. Subramanian
  • Patent number: 11324966
    Abstract: A delivery system and method for radiation shielded brachytherapy has a drive assembly, and a plurality of shield assemblies, pivotally mounted to the drive assembly, each having a tubular body defining an outer surface and a bore longitudinally extending between opposite ends of the tubular body. Each of the shield assemblies has radiation shielding material extending about a circumferential portion of the tubular body and disposed between the outer surface and the cavity. An interlocking system is operatively mounted to the rotating assembly, and engages a group of the plurality of shield assemblies. The interlocking system is configured for transmitting a rotational input received from a driving mechanism to the group of shield assemblies, for synchronously rotating each shield assembly of the group about their respective longitudinal axis.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: May 10, 2022
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Shirin Abbasi Nejad Enger, Gabriel Famulari
  • Patent number: 11318326
    Abstract: The disclosure pertains to a strontium-90 sealed radiological or radioactive source, such as may be used with treatment of the eye or other medical or industrial processes. The sealed radiological source includes a radiological insert within an encapsulation. The encapsulation may include increased shielding in the center thereof.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: May 3, 2022
    Assignee: QSA GLOBAL INC.
    Inventors: Mark G. Shilton, Mark W. Vose, Jason W. Bourn
  • Patent number: 11318288
    Abstract: A medical instrument that includes a needle and an expandable member located at a distal end of the needle. The expandable member includes a blocking member. The expandable member is configured to move tissue away from a distal end of the needle and/or from a distal end of a tubular member that is in fluid communication with a substance source. A substance is configured to be expelled into the anatomy through the expandable member. The blocking member is configured to restrict or prevent the substance from being expelled through the portion of the expandable member that includes the blocking member.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: May 3, 2022
    Assignee: Gyrus ACMI, Inc.
    Inventors: Huisun Wang, Kester J. Batchelor
  • Patent number: 11278736
    Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: March 22, 2022
    Assignee: GT MEDICAL TECHNOLOGIES, INC.
    Inventors: David Brachman, Peter Nakaji, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Patent number: 11273325
    Abstract: Systems and devices for applying radiation to a target area, for example for maintaining functioning drainage blebs or functioning drainage holes in the eye, e.g., to reduce intraocular pressure (IOP) of an eye being treated for glaucoma. The systems and devices of the present invention provide for the application of beta radiation to the target area, wherein the beta radiation can function to inhibit or reduce the inflammation and/or fibrogenesis that may occur after insertion of an implant into the eye or introduction of a hole for the purpose of draining aqueous humor to maintain a healthy intraocular pressure. By reducing inflammation and/or fibrogenesis, the implant, the hole, the blebs, or other related structures or tissues can remain functioning appropriately.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: March 15, 2022
    Assignee: RADLANCE THERAPEUTICS, INC.
    Inventors: Laurence J. Marsteller, James A. Fazio, Ian Murdoch
  • Patent number: 11247069
    Abstract: A method of treatment including: selecting tissue to be exposed to radiation for gradual closure of one or more blood vessel within the tissue to be exposed radiation; selecting radiation levels to promote gradual constriction of the one or more vessel; exposing the tissue to be exposed radiation to selected radiation levels.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: February 15, 2022
    Assignee: LuSeed Vascular Ltd.
    Inventors: Nitzan Hirsh, Amir Arthur
  • Patent number: 11249000
    Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: February 15, 2022
    Assignees: Arizona Board of Regents on Behalt of the University of Arizona, inviCro, LLC
    Inventors: Harrison H. Barrett, Yijun Ding, Luca Caucci, John William Hoppin
  • Patent number: 11213700
    Abstract: A brachytherapy afterloader device, comprises at least one transmit wire that is suitable for being inserted and driven in an advance or retract motion in an external first delivery channel and for delivering drive energy to a test field source, which is arranged at a distal end region of the transmit wire, for generating a magnetic test field; at least one receive wire that is suitable for being inserted and driven in an advance or retract motion in an external second delivery channel for a measurement of the magnetic test field, the receive wire having a transducer that is configured to detect magnetic-field changes in the magnetic test field; and a wire driving unit which is configured to controllably advance or retract the transmit wire and the receive wire in response to a corresponding test drive control signal.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: January 4, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Guillaume Leopold Theodorus Frederik Hautvast
  • Patent number: 11147620
    Abstract: According to one aspect of the present disclosure, a microwave antenna assembly is disclosed. The antenna assembly includes a feedline having an inner conductor, an outer conductor and an inner insulator disposed therebetween and a radiating portion including a dipole antenna having a proximal portion and a distal portion. The antenna assembly also comprises a sheath disposed over the feedline and the radiating portion defining a chamber around the feedline and the radiating portion. The chamber is adapted to circulate coolant fluid therethrough. The antenna assembly further includes a connection hub having cable connector coupled to the feedline, an inlet fluid port and an outlet fluid port. The connection hub includes a bypass tube configured to provide for flow of the coolant fluid from the cable connector directly to the outlet fluid port.
    Type: Grant
    Filed: July 14, 2018
    Date of Patent: October 19, 2021
    Assignee: COVIDIEN LP
    Inventors: Richard A. Willyard, Joseph D. Brannan
  • Patent number: 11134946
    Abstract: A surgical stapler, cartridge assembly, and related methods are disclosed. A cartridge assembly for a surgical stapler has a first cartridge portion; and a second cartridge portion; wherein each of the first and second cartridge portions has an upper surface for engaging tissue, and a slot to house a staple. A proximal portion of each of the first and second cartridge portions has a guide portion having at least one of a channel or a protrusion for guiding at least a portion of an i-beam. The second cartridge portion is removably couplable to the first cartridge portion to form a channel.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: October 5, 2021
    Assignee: Bolder Surgical, LLC
    Inventors: Richard N. Granger, Allison B. Lyle, Joseph D. Bucciaglia
  • Patent number: 11135323
    Abstract: Provided is a process of producing activated particles comprising 188Re-isotopes and/or 186Re-isotopes by irradiating non-volatile and water-insoluble starting particles comprising a rhenium compound with neutrons. Further provided is a process of producing corresponding non-volatile and water-insoluble starting particles. Further provided are respective starting particles and activated particles, respectively, and a composition comprising a plurality of activated particles. The activated particles, and the composition comprising same are suitable for use in radionuclide therapy, and for cosmetic applications.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 5, 2021
    Assignee: ONCOBETA INTERNATIONAL GMBH
    Inventors: Tuomo Nikula, Thomas Wendler
  • Patent number: 11130004
    Abstract: Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 28, 2021
    Assignee: Cianna Medical, Inc.
    Inventors: George D. Hermann, Eduardo Chi Sing, Gail S. Lebovic, Mark A. Cole, Mark A. Ritchart, Than Nguyen
  • Patent number: 11116992
    Abstract: The disclosure pertains to improvements in a gamma radiation source, typically containing low-density alloys or compounds or composites of iridium in mechanically deformable and compressible configurations, within a sealed encapsulation, and methods of manufacture thereof.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: September 14, 2021
    Assignee: QSA GLOBAL, INC.
    Inventor: Mark Shilton
  • Patent number: 11103264
    Abstract: A clot retrieval device with an elongate shaft and an expandable section, the expandable section having a framework of interconnected strut elements distal of the elongate shaft, the strut elements forming an outer expandable body and an inner expandable body. At least a portion of the strut elements include a first coating of radiopaque material defining a plurality of micro-columns, wherein each micro-column includes a length extending between a first end coupled to one of the plurality of strut elements and a second free end opposite the first end, the length of each micro-column is longer than a width of each micro-column. The second free end is capable of moving further apart when a convex bend is applied to the respective strut element during use. Also including a second coating.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: August 31, 2021
    Assignee: NEURAVI LIMITED
    Inventors: David Vale, Eamon Brady, Michael Gilvarry, David Hardiman, Brendan Casey
  • Patent number: 11058489
    Abstract: Microwave ablation devices and systems and method including the devices are provided. The microwave ablation device includes a cable assembly operably coupled to an energy source, a feedline in electrical communication with the cable assembly, a balun disposed on the feedline, an outer tubular member through which the feedline at least partially extends, and an inflatable barrier disposed on the outer tubular member proximal to the balun.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: July 13, 2021
    Assignee: COVIDIEN LP
    Inventor: Kathy E. Rooks
  • Patent number: 11051842
    Abstract: A tissue-removing catheter for removing tissue in a body lumen includes an elongate body and a tissue-removing element mounted on a distal end portion of the elongate body. The tissue-removing element is configured to remove the tissue as the tissue-removing element is rotated by the elongate body within the body lumen. An inner liner is received within the elongate body and coupled to a handle at a proximal end of the inner liner. The inner liner defines a guidewire lumen. The inner liner isolates an interior of the guidewire lumen from the elongate body and tissue-removing element such that rotational and torsional forces are not transferred from the elongate body and tissue-removing element to the interior of the guidewire lumen when the elongate body and tissue-removing element are rotated during operation of the tissue-removing catheter.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: July 6, 2021
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventors: Aram Jamous, John Kelly, Matthew Fleming, Colin William Meade, Grainne Teresa Carroll
  • Patent number: 11045667
    Abstract: Real-time X-ray dosimetry sensing in intraoperative radiation therapy (IORT). According to one aspect, a treatment head comprises at least one X-ray component configured to facilitate generation of therapeutic radiation in the X-ray wavelength range. A resilient balloon is disposed over the treatment head and configured for receiving therein a fluid to facilitate X-ray treatment of a tumor cavity. A plurality of X-ray sensing elements is disposed at a plurality of locations distributed on the interior or exterior of the resilient balloon and configured for sensing X-ray radiation emanating from the treatment head. A control system is provided that is responsive to data received from the X-ray sensing elements to determine a magnitude of X-ray radiation detected at each of the X-ray sensing elements.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: June 29, 2021
    Assignee: SENSUS HEALTHCARE, INC.
    Inventor: Kalman Fishman
  • Patent number: 11020000
    Abstract: A luminescent ophthalmic device for administering therapeutic materials, the device having at least one luminescent marker disposed in proximity to a therapeutic agent applicator so as facilitate placement in a treatment position when viewed using transcorneal or transpupillary viewing methods.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: June 1, 2021
    Assignee: IP LIBERTY VISION CORPORATION
    Inventors: Paul T. Finger, Toby Welles
  • Patent number: 11000370
    Abstract: Implantable devices including conduits that have markings along the length of the conduit are described herein.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: May 11, 2021
    Assignee: PECA Labs, Inc.
    Inventors: C. Douglas Bernstein, Arush Kalra, Denver Faulk
  • Patent number: 11000392
    Abstract: A crimping method that crimps a stent over multiple catheters. The method includes differentially crimping a stent on certain portions of a balloon catheter so that a second catheter can be threaded through the uncrimped portion of the stent and exit through the links of a conventional stent design or through a specific hole in the stent designed for a branched vessel.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: May 11, 2021
    Assignee: Advanced Bifurcation Systems Inc.
    Inventors: Henry Bourang, Mehran Khorsandi
  • Patent number: 10967198
    Abstract: The invention describes method for delivering and positioning radio-isotopes. The method uses encapsulating free flowing medicament into a vehicle and positioning the vehicle into the body. Also provided is a system for delivering and positioning radio-isotopes into the body, the system comprising fluid radio-isotope encapsulated in a material.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: April 6, 2021
    Inventor: Arnold Herskovic
  • Patent number: 10959865
    Abstract: An intracranial stent includes a proximal end, a distal end, and a tubular sidewall extending there between and a patch covering at least a portion of the sidewall; wherein the patch is capable of diverting blood flow past the neck of an intracranial aneurysm. The patch may be made of a photon-activatable material or a tightly woven metal material with a density greater than a density of the sidewall itself.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: March 30, 2021
    Inventor: Jeffrey E. Thomas
  • Patent number: 10952631
    Abstract: A biomagnetism measurement device includes a tubular body, an inflatable portion inflatable upon supply of gas, and a magnetic sensor portion that detects a magnetic field from outside the tubular body. The inflatable portion is located at a required region of the tubular body, and the magnetic sensor portion is fixed to an inner wall of the inflatable portion. The tubular body and the inflatable portion include the same material, and the wall thickness of the inflatable portion is thinner than that of the tubular body.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: March 23, 2021
    Assignees: National University Corporation Tokyo Medical and Dental University, TDK CORPORATION
    Inventors: Shigenori Kawabata, Satoshi Sumiya, Shuichi Okawa
  • Patent number: 10950362
    Abstract: The disclosure pertains to a strontium-90 sealed radiological or radioactive source, such as may be used with treatment of the eye or other medical or industrial processes. The sealed radiological source includes a toroidal shaped strontium radiological insert within an encapsulation. The encapsulation includes increased shielding in the center thereof.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: March 16, 2021
    Assignee: QSA GLOBAL, INC.
    Inventors: Mark W. Vose, Mark G. Shilton, Jason W. Bourn
  • Patent number: 10926105
    Abstract: A surgical implant includes a biocompatible member configured for securement to an underlying target surgical site and a radiation source integrated into or onto the biocompatible member. The surgical implant may be one of a clip, pin, or coil and the radiation source includes at least one brachytherapy capsule, or other radioactive material incorporated therein or provided thereon. The radioactive material provides a dose of radiation to the target surgical site. The surgical implant may also be formed from titanium, stainless steel or polymers. A surgical applier is provided for allowing a surgeon to apply the implant to a patient's tissue.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: February 23, 2021
    Assignee: COVIDIEN LP
    Inventors: David Racenet, Gerald Hodgkinson, Abhinav Kachru
  • Patent number: 10925727
    Abstract: A medical device delivery system can include a dilator including a tip having a taper in a distal direction, a coupler, and a flap that radially protrudes from the tip. The flap can be configured to bend against a body lumen to cover at least a portion of the delivery system when the dilator is tracked through the body lumen. A medical device delivery system can include a dilator including a tip having a lumen and a coupler having a lumen. The coupler can be configured to securely connect to the tip such that the lumen of the tip is aligned with the lumen of the coupler to allow a guide wire to pass therethrough. Methods for loading a medical device into a delivery catheter are also disclosed.
    Type: Grant
    Filed: January 7, 2018
    Date of Patent: February 23, 2021
    Assignee: MEDTRONIC CV LUXEMBOURG S.A.R.L.
    Inventors: Niall Duffy, John Gallagher, Gerry McCaffrey, Noam Miller, Glenn Stante
  • Patent number: 10918829
    Abstract: An expandable sheath may include an inelastic compliant membrane having a lumen therethrough, and a discontinuous outer member bonded to the membrane. The membrane may include one or more folds formed therein. At least a portion of the outer member may extend continuously around a circumference of the membrane in a first configuration. The outer member may be configured to separate to a second configuration when subjected to a radially outward force from within the membrane. The outer member may taper from a first diameter adjacent a proximal hub to a second smaller diameter at a distal end. A method of manufacturing an expandable sheath may include forming one or more folds in a compliant membrane, cutting a plurality of apertures through a wall of an outer covering; and laminating the outer covering onto the membrane, wherein the plurality of apertures is disposed over the one or more folds.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: February 16, 2021
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Mimi Trinh Fitterer, Takashi H. Ino, Randy S. Gamarra, Floriza Q. Escalona
  • Patent number: 10869996
    Abstract: An intra-tumoral agent deployment apparatus for diagnosing and delivering targeted, sequential deployment of agents to an endo-bronchial and, or an intra-parenchymal tumor, said apparatus formed of, among other things, an elongated shaft assembly including: at least one lumen; an intra-tumoral probe wire for tumor traversal, slidably interposed there between or slidably disposed between any one of, or combination of the at least one lumen; and wherein the displacement of the intra-tumoral probe wire causes disruption of an endo-bronchial and, or an intra-parenchymal tumor tissue, and, or creating an inlet for deployment of at least a first agent comprising any one of a therapeutic agent and, or a delivery vehicle from the first lumen, and a subsequent second agent comprising any one of a therapeutic agent and, or a binding agent from any one of the first lumen, second lumen, and, or the delivery vehicle.
    Type: Grant
    Filed: October 29, 2016
    Date of Patent: December 22, 2020
    Inventor: Stephen Kuperberg
  • Patent number: 10850118
    Abstract: Methods and devices for minimally-invasive delivery of radiation to the eye (such as the posterior portion of the eye) including cannula systems with multiple treatment positions and/or multiple channels in the distal tip of the cannula systems. The channels can accommodate emanating sources and exposing a target at various treatment positions. The emanating sources may be annulus-shaped.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: December 1, 2020
    Assignee: SALUTARIS MEDICAL DEVICES, INC.
    Inventors: Wendell Lutz, Russell J. Hamilton, Thomas C. Cetas, Laurence J. Marsteller, Timothy Shriver, Samuel S. Hyman
  • Patent number: 10773099
    Abstract: A material for brachytherapy is provided comprising a substrate having a longitudinal axis and a latitudinal, wherein the substrate comprises alternating peaks and valleys which are parallel to the longitudinal axis, the alternating peaks and valleys defining latitudinally extending pleats; and a plurality of medicament moieties positioned on the peaks and valleys of the substrate.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: September 15, 2020
    Inventor: Arnold M. Herskovic
  • Patent number: 10773100
    Abstract: Methods and devices are disclosed for treating a patient with an unruptured saccular aneurysm that is not associated with an arteriovenous malformation, wherein ionizing radiation is delivered to the brain of a patient through stereotactic radiosurgery. The radiosurgery may be performed with a Gamma Knife stereotactic radiosurgery apparatus, LINAC device such as CYBERKNIFE® stereotactic radiosurgery apparatus, or particle-beam device. The treatment impedes a natural progression of the aneurysm towards rupture and may actually obliterate the aneurysm. The treatment plan may be based in part on measured geometric properties of the aneurysm or on physical aneurysm properties such as permeability, wall thickness, wall motion, the presence of macrophages, shear stress, and flow velocities. The methods may be used in conjunction with endovascular coil embolization.
    Type: Grant
    Filed: July 29, 2017
    Date of Patent: September 15, 2020
    Inventor: John D. Lipani
  • Patent number: 10758193
    Abstract: The invention relates to a medical radiation protector, which is configured in such a way that said radiation protector holds tumor tissue and adjoining healthy tissue in a clear relative position with respect to each other in the head-and-neck region during a radiation treatment for cancer therapy, and which comprises at least a lower jaw element, an upper jaw element, and optionally a tissue protection element, and which is produced partially from a plastic that can be used in an additive method and that is approved for use in/against/on a human or animal body for medical purposes, wherein the part produced from said plastic is produced by means of an additive production method. The invention further relates to a production method for said radiation protector, to a system for performing the method, and to a computer program that substantially controls the method.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: September 1, 2020
    Assignee: HIBRAND INDUSTRIES AG
    Inventor: Remo Bettega
  • Patent number: 10709901
    Abstract: A fastener applicator includes a body portion including a handle assembly, a cartridge assembly supported within the body portion, the cartridge assembly including implantable fasteners, a drive assembly supported within the body portion and operatively coupled to the cartridge assembly to engage the implantable fasteners, and an actuation assembly supported within the handle assembly and operatively coupled to the drive assembly to fire a distal-most implantable fastener upon actuation of the actuation assembly. At least one of the implantable fasteners includes a body including a tissue facing surface, a tissue penetrating portion extending from the body, and a capsule affixed to the tissue facing surface of the body, the capsule including radioactive material.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: July 14, 2020
    Assignee: Covidien LP
    Inventors: Stanislaw Kostrzewski, Gerald Hodgkinson, Lee Ann Olson, Russell Pribanic, Matthew Chowaniec, Robert Pedros, Thomas Campanelli, David Nicholas
  • Patent number: 10702307
    Abstract: A multi-cannula surgical instrument (1), having an inner cannula (3) movably disposed within an outer cannula (2), the inner cannula (3) having a blunt distal tip (3b), one or more first inner ducts (31) and one or more first flow-through orifices (32) arranged to allow one or more fluid flows therethrough, where the inner and the outer cannula (2, 3) at the proximal ends (2a, 3a) thereof are mounted onto a hub (4) that includes a biasing mechanism (43) coupled to the inner cannula (3) and arranged to bias the inner cannula (3) automatically from a retracted towards an advanced position in case of absence of resistance against the inner cannula (3), where the outer cannula (2) has one or more second flow-through orifices (22) that are in fluid communication with one or more second ducts (21) arranged between the outer and the inner cannula (2, 3), where the second flow-through orifices (22), the hub (4) and the second duct(s) (21) are configured to allow at least one fluid flow therethrough.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: July 7, 2020
    Assignee: Vesalius Medical Technologies BVBA
    Inventor: Kristoffel Pieter Maria Mulier
  • Patent number: 10688316
    Abstract: To provide patient shielding of non-treatment areas bordering a treatment zone of the patient during radiation therapy, a shield device may be located on the patient. The shield device has a plurality of interconnected and overlapping elements, e.g. in a scale maille arrangement, that forms a conformal sheet that can be laid over the shielded portion of the patient, e.g. over the contralateral breast during breast cancer treatment. The edge of the scale maille sheet is substantially configurable and can be made to conform to the field edge of the treatment zone on the patient.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: June 23, 2020
    Inventor: Macinley Butson
  • Patent number: 10685451
    Abstract: An image registration method includes acquiring first image data for a target object that includes first coordinate information; acquiring second image data for the target object that includes second coordinate information, by using a probe; and registering the first image data with the second image data, using the first coordinate information and the second coordinate information. According to the image registration method, image registration between a plurality of pieces of volume data adjusted so that their coordinate axes correspond to each other is performed, whereby a high-quality registered image may be quickly and simply obtained.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: June 16, 2020
    Assignee: SAMSUNG MEDISON CO., LTD.
    Inventors: Dong-kuk Shin, Bong-koo Seo, Sung-jin Choi
  • Patent number: 10674973
    Abstract: One aspect of the invention provides a system for radiation treatment of a tumor allowing for imaging of the tumor and a surrounding region during radiation therapy and to methods of using such a system. In one embodiment, the system includes a number of radiation detectors positioned in an array to detect radiation scattered from the tumor and the surrounding region. A 3-dimensional image of the tumor is reconstructed from the 2-dimensional scattered radiation projections.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: June 9, 2020
    Assignees: Rush University Medical Center, UChicago Argonne, LLC
    Inventors: James Chu, William F. Sensakovic, Damian Bernard, Gage Redler, Steve Wang
  • Patent number: 10650532
    Abstract: A phase correlation method (PCM) can be used for translational and/or rotational alignment of 3D medical images even in the presence of non-rigid deformations between first and second images of a registered volume of a patient.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: May 12, 2020
    Assignee: VIEWRAY TECHNOLOGIES, INC.
    Inventors: Georgi Gerganov, Iwan Kawrykow
  • Patent number: 10646727
    Abstract: Aspects herein are directed to an anchorable brachytherapy device configured to be permanently implanted in a tumor bed at the time of operative removal of the tumor. In exemplary aspects, the brachytherapy device may comprise a plurality of hollow tubes that form a spherical or ellipsoid shape. Protrusions or grooves may be formed on an outer surface of the tubes to help anchor the brachytherapy device in the tumor bed. Radioactive seeds or strands may be positioned within the tube channels to provide radiation to the tumor bed.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: May 12, 2020
    Assignee: Positive Energy, LLC
    Inventor: Ibrahim Abdalla