Abstract: Certain aspects relate to systems and techniques for navigation path tracing. In one aspect, a system displays a preoperative model of a luminal network is displayed. The system determines a position of an instrument within the luminal network relative to the preoperative model. Based on the position of the instrument relative to the preoperative model, the system determines whether to enter a path tracing mode. In path tracing mode the system displays visual indicia indicative of a path of the instrument with respect to the displayed preoperative model. The visual indicia may be used to visual the navigation path of the instrument and/or to extend the preoperative model.

Abstract: Various medical devices and related systems, including robotic and/or in vivo medical devices, and various robotic surgical devices for in vivo medical procedures. Included herein, for example, is a robotic surgical system having a support beam positionable through an incision, and a robotic device having a device body, first and second rotating shoulder components coupled to the device body, and first and second robotic arms coupled to the first and second shoulder components, respectively.

Abstract: A medical system tracks the position of a medical instrument within a body of a patient. The medical instrument includes an elongated flexible printed circuit and an electromagnet structure having a conductive coil wound around a core. A control circuit applies an excitation signal across the conductive coil. Electrical current running through the conductive coil (wound around the core) generates a magnetic field. A plurality of sensors sense parameters of the magnetic field and output sensor signals. The control circuit calculates the position of the medical instrument based on the sensor signals.

Abstract: An apparatus and method for using rotating shield brachytherapy (RSBT). In an aspect, the RSBT system and method can be used to maintain or increase tumor dose relative to conventional techniques with a dramatic reduction in radiation dose to the urethra, rectum, and bladder in the treatment of prostate cancer through placing partially shielded radiation sources away from sensitive tissues. In an aspect, the invention is an apparatus and method for the precise angular and linear positioning of multiple partially-shielded radiation sources in interstitial needles. In a further aspect, the invention comprises a monitoring and control apparatus for the precise and simultaneous angular positioning of multiple shield-containing catheters in the RBST system by measuring and correcting deviations between actual and desired catheter angular positions and depth in real time before and during treatment delivery.

Abstract: A cognitive optical system for dynamically refining imaging during a medical procedure, involving a processor operable by a set of executable instructions storable in relation to a non-transitory memory device. The processor is configured to automatically adjust an image by automatically compensating for at least one external factor affecting an anatomical area being viewed, automatically adjusting at least one imaging parameter, and automatically adjusting at least one internal control of an optical chain, whereby a quality of the image is improvable in real time.

Abstract: Disclosed herein are device and methods for determining an orientation of an instrument for inserting a medical device in a bone. One such method includes simulating an insertion point and an orientation of a simulated surgical hardware installation on a diagnostic representation of the bone, and then using an electronic device to align an instrument for inserting a surgical hardware installation at a desired orientation through an insertion point of the bone by indicating when an orientation of the electronic device is within a threshold of the simulated orientation.

Abstract: A method of decellularizing a tissue includes disposing the tissue within a device, the device. The device includes a container, first and second electrodes disposed within the container and defining a space between the first and second electrodes to receive the tissue, a perfusion pump, and a conduit connected to the perfusion pump to transport a decellularization composition from the pump into the tissue. The method further includes disposing the decellularization composition within the container to surround the tissue and contact the first and second electrodes, applying an electric potential across the first and second electrodes, and perfusing the decullarization composition into the tissue.

Abstract: In an automated methodology for in vivo image-guided cell patch clamping, a cell patch clamping device is moved into position and targeted to a specific cell using automated image-guided techniques. Cell contact is determined by analyzing the temporal series of measured resistance levels at the clamping device as it is moved. The difference between successive resistance levels is compared to a threshold, which must be exceeded before cell contact is assumed. Pneumatic control methods are used to achieve gigaseal formation and cell break-in, leading to whole-cell patch clamp formation. An automated robotic system capable of performing this methodology automatically performs patch clamping in vivo, automatically locating cells through image guidance and by analyzing the temporal sequence of electrode impedance changes.

Abstract: It is an object of the invention to improve tissue classification in MRI images. In particular it is an object of the invention to improve the classification of bone and air in MRI images. This object is achieved by a method for tissue classification in a region of interest in a magnetic resonance (MR) image comprising a first region and a second region, wherein the first region represents air and the second region represents bone.

Abstract: A method of maintaining patient registration in surgical navigation includes: obtaining a patient position in a tracking system frame of reference, based on a fiducial marker array affixed in a first position relative to the patient; receiving an initial surface scan depicting the patient and the fiducial array; responsive to receiving an intraoperative image depicting the patient: obtaining a position, in the tracking system frame of reference, of the fiducial array affixed in a second position relative to the patient; receiving a secondary surface scan depicting the patient and the fiducial array; detecting a deviation in a position of the fiducial marker array relative to the patient between the initial and secondary surface scans; and applying the deviation to the position of the patient to generate an updated position of the patient in the tracking system frame of reference, based on the fiducial array affixed in the second position.

Abstract: The present technology relates to an input control device, an input control method, and an operation system, which enable achievement of a highly flexible input operation without a burden on a user. A target point determination unit determines a target point to be a display reference in an operative field image in a display, on the basis of a user's line-of-sight position with respect to the operative field image displayed in the display and of a characteristic point detected in the operative field image. The present technology can be applied to an input device for an operation system.

Abstract: This document relates to a medical application of augmented reality in which areal image shows a medical device, or at least a part thereof. In an exemplary application, the real image further shows at least a part of a patient's body which is (to be) treated using the medical device. A part of the medical device might not be visible in the real image, for example because it extends into or behind the patient's body. In this case, the virtual image can comprise an augmentation of the medical device, which, for example, represents at least the part of the medical device which is invisible in the real image. This document in particular addresses a correct alignment of the augmentation with the medical device.

Abstract: The present invention provides a tool and method for performing a lumbar puncture. The tool may include a first arm and a second arm and may form a T-shape. The first arm may be longer than the second arm. Also included is a projection extending from one of the arms. The projection has a downward angle and a passageway that is sized to accommodate a needle. The tool is configured to maintain the perpendicular placement of a needle between vertebrae and a preferred angle of insertion of about 15° during a procedure.

Abstract: A controller generates, based on a position of a marker in an X-ray image, an intermediate image in which a device inserted into a subject's body is displayed. After the generation of the intermediate image, the controller matches the marker of the X-ray image with a marker of the intermediate image based on the position of the marker in the X-ray image and a position of a marker in the intermediate image to align the X-ray image and the intermediate image with each other every time the X-ray image is newly generated. The controller then controls the display to display an overlaid image generated by overlaying the X-ray image and the intermediate image aligned with each other.

Abstract: A method is for output of position information of a medical instrument, configured to penetrate at least partly an area of the body of a patient. A structure image, an instrument image and an operation scene image are registered with one another. A registered structure image, a registered instrument image and a registered operation scene image are produced from the registration. An overlay image is displayed with a VR or AR display facility, including at least parts of the registered structure image of the registered operation scene image (BrO)—or the real view of the corresponding part of the real area of the body—and of the registered instrument image. A corresponding image generation system is also disclosed.

Abstract: A multicolor 2D-photo-marker including a rectangular matrix of data pixels, framed by a contrasting matrix locator, wherein the rectangular matrix of data pixels includes at least one orientation data pixel that carry photo-marker orientation information and is located at a pre-selected location, and wherein a unique color and location combination of the multiple data pixels encodes identification information of the object with which the multicolor 2D-photo-marker is coupled with. Preferably, the rectangular matrix of data pixels further includes color reference pixels, each located at a pre-selected location, designated to serve as dictionary hue pixels. Preferably, the pre-selected location of each color reference pixels is at a corner of the rectangular matrix of data pixels. An orientation data pixel may also serve as a color reference pixel.

Abstract: A system for registration feedback includes a segmentation module configured to segment a relevant three-dimensional structure in a first image to be registered and to segment a same relevant structure in a second image to be registered to provide three-dimensional segmentations of the first and second images. A registration module is configured to register the three-dimensional segmentations of the first and second images by applying a registration transformation to one of the three-dimensional segmentations to map one three-dimensional segmentation onto the coordinate space of the other.

Abstract: A system for facilitating vascular access is disclosed. The system includes an imaging device including a transducer configured for ultrasound image data acquisition, an ECG signal acquisition device configured to acquire ECG signal data via one or more leads, wherein a first lead is directly connected to skin of a patient, and a mobile application configured to render a graphical user interface to be displayed on a display screen of a mobile device, wherein the graphical user interface illustrates a representation of at least one of the ultrasound image data or the ECG signal data that is wireless transmitted to the mobile device.

Abstract: A method includes receiving an anatomical mapping that includes multiple measurements acquired at multiple respective locations within an organ of a patient. An estimated surface of the organ is computed based on the measurements. A three-dimensional (3D) shell of the organ, which extends inwards from the estimated surface of the organ and has a predefined thickness, is defined. A quality of the anatomical mapping is estimated based on the measurements whose locations fall within the 3D shell.

Abstract: A method for measuring and representing the level of local irradiation doses, in at least two dimensions, comprises: a step of positioning N probes Si sensitive to irradiating radiation, each corresponding to a local zone Zi according to a known topology; a step of acquiring, by each of the probes, the level of radiation ISi detected and periodically recording numerical values ISi(t); and a step of converting the numerical values ISi(t) into values DSi(t) corresponding to the radiation dose applied to each of the Z zones associated with a probe Si, according to a calibration table. The method further comprises, during the measurement sequence, steps of spatial interpolation calculation of at least one estimated irradiation level value ISiv(t) of at least one virtual zone Ziv that is not associated with a probe. A measurement device for implementing this method is also described.

Abstract: Methods and systems for performing robotically-assisted surgery in conjunction with intra-operative imaging. A method includes moving a robotic arm with respect to a patient and an imaging device to move an end effector of the robotic arm to a pre-determined position and orientation with respect to the patient based on imaging data of the patient obtained by the imaging device. The robotic arm maintains the end effector in the pre-determined position and orientation with respect to the patient and does not collide with the imaging device or with the patient when the imaging device moves with respect to the patient.

Abstract: A kit including a medical guide template, and a sterilizable receptacle accommodating the guide template, the kit being configured to allow deformation of the template into an operational medical guide.

Abstract: An endoscopic camera has two or more cameras positioned at a distal end, positioned to provide partially overlapping fields of view. The cameras communicate captured digital images the length of the flexible endoscope, where they may be saved and processed to provide additional imaging features. With partially overlapping images from two or more cameras, image processing can provide panoramic images, super resolution images, and three-dimensional images. One or more of these image modes may also be enhanced to provide a virtualization window that displays a portion of a larger or higher resolution image. The virtualization window displays the selected area of the image, and may be moved or zoomed around the image to provide a virtual endoscope repositioning experience, where the endoscope remains statically positioned but the virtualization window presents a sense of movement and navigation around the surgical area.

Abstract: A camera image is acquired by a camera and a structure that is optically concealed in the camera image is acquired by a material-penetrating acquisition modality. A stereoscopic depth location of a common reference point is then fixed at a predetermined value. The stereoscopic representation is then generated from the camera image, and an overlay image is generated based on the concealed structure. In this case, a depth location of the camera image is fixed at the depth location of the reference point, and, as a function thereof, a depth location of the overlay image is adjusted in relation to the depth location of the reference point, such that in the stereoscopic representation, the overlay image appears realistically in front of and/or behind an optically opaque part in the recording direction of the camera image.

Abstract: Described herein is an anti-skid surgical instrument for use in preparing holes in bone tissue. The disclosed surgical instrument provides the ability to prepare a precise hole in bone tissue during surgery (e.g., spinal surgeries and pedicle screw placement, intramedullary screw placement). The disclosed surgical instrument accomplishes precise hole placement regardless of whether the angle between the drill axis and surface of the bone tissue is perpendicular. The disclosed technology includes a flat drilling surface which is perpendicular to the surface of the body of the surgical instrument. This reduces the likelihood of the surgical instrument skidding on the surface of the bone tissue and thereby increases the precision of the hole.

Abstract: A method of detecting dislodgement of a navigational reference for a localization system includes securing a reference catheter, including at least one reference localization element, at an initial reference location within a localization field. The positions of one or more of the reference localization elements are monitored for a perceived displacement that suggests that the reference catheter has become dislodged from the initial reference location (e.g., a displacement above a certain threshold, such as about 4 mm). The direction of this perceived displacement may then be further analyzed (e.g., compared to a predicted or most likely direction of displacement) to determine whether there has been an actual dislodgement of the reference catheter, and, if so, an appropriate signal (e.g., an audible or visual warning) may be generated. Upon dislodgement, guidance may be provided to aid the practitioner in restoring the reference catheter to its initial location.

Abstract: A system for implanting a prosthesis includes a prosthesis that extends about a major longitudinal axis and an alignment device connected to the prosthesis. The alignment device appears asymmetric across a plane coplanar to a longitudinal axis of the prosthesis when viewed both along the plane and transversely to the longitudinal axis of the prosthesis delivery and also lies in a plane parallel to and spaced apart from the longitudinal axis of the prosthesis. The alignment device is visible to a user, thereby indicating a rotational and an axial position of the prosthesis with respect to the treatment site prior to implantation of the prosthesis at a treatment site. In an embodiment, the system includes a guidewire catheter that is asymmetric along a major longitudinal axis.

Abstract: Embodiments disclose a real-time surgery method and apparatus for displaying a stereoscopic augmented view of a patient from a static or dynamic viewpoint of the surgeon, which employs real-time three-dimensional surface reconstruction for preoperative and intraoperative image registration. Stereoscopic cameras provide real-time images of the scene including the patient. A stereoscopic video display is used by the surgeon, who sees a graphical representation of the preoperative or intraoperative images blended with the video images in a stereoscopic manner through a see-through display.

Abstract: An implant for therapeutically separating bones of a joint has two endplates each having an opening through the endplate, and at least one ramped surface on a side opposite a bone engaging side. A frame is slideably connected to the endplates to enable the endplates to move relative to each other at an angle with respect to the longitudinal axis of the implant, in sliding connection with the frame. An actuator screw is rotatably connected to the frame. A carriage forms an open area aligned with the openings in the endplates. The openings in the endplates pass through the carriage to form an unimpeded passage from bone to bone of the joint. The carriage has ramps which mate with the ramped surfaces of the endplates, wherein when the carriage is moved by rotation of the actuator screw, the endplates move closer or farther apart.

Abstract: Systems for detecting when catheter electrodes enter into and exit from an introducer are disclosed. In one form, a system detects a relative position of a catheter (comprising a marker band and an electrode) and an introducer (comprising a proximity sensor adapted to sense the marker band), while the catheter and introducer are in a human body. The system may comprise an electronic control unit to analyze signals from the catheter and/or the introducer, to determine whether the catheter electrode is within the introducer; and to disregard data collected from the electrode when that electrode is in the introducer. The sensor may be on the catheter and the sensed element may be on the introducer. The sensed element may comprise one or several marker bands. A marker band may be applied during the manufacture of a medical device or during its use and is any element capable of electromagnetic detection.

Abstract: The invention disclosed here generally relates to devices used to identify the location of a never in order to modify a property of the nerve. Specifically, the invention utilized pre-operative scans of a patient's nasal cavity in order to identify target treatment locations when a nerve to be treated is located. The image of the nasal cavity and target treatment location can be registered with the real time position of the nasal cavity using a surgical navigation system in order to assist in guiding a surgical probe to the target treatment location.

Abstract: An embodiment in accordance with the present invention provides a precise catheter tracking system, Active Ultrasound Pattern Injection System (AUSPIS). AUSPIS establishes ultrasonic communication between any ultrasound external probe and internal catheter (CUTE catheter). The system receives image beacon pulses, analyzes the acquired signal, and fires one or a series of active echo pulses from the same active echo element with a proper timing, frequency, duration and amplitude. Thus it enables injection of any “virtual” pattern into the B-mode image. The pattern injected to the B-mode image is from actively encoded ultrasound field in the tissue. The encoding is based on B-mode ultrasound image formation technique, so it doesn't require hardware or software modification to the US machine. It continuously measures the local acoustic signal amplitude, by which sub-millimeter elevation localization accuracy can be achieved.

Abstract: According to an embodiment, a transmitter transmits a reference signal. A position sensor obtains position information in a three-dimensional space by receiving the reference signal. A controlling unit associates three-dimensional image data generated by a medical image diagnosis apparatus with the three-dimensional space, on the basis of a registration between an arbitrary cross-sectional plane in the three-dimensional image data and a cross-sectional plane scanned by an ultrasound probe. A detecting unit detects if the position of the transmitter has changed within the associated three-dimensional space, on the basis of the position information obtained by the position sensor. A correcting unit corrects a misregistration between a cross-sectional plane in the three-dimensional image data and a cross-sectional plane scanned by the ultrasound probe, on the basis of a change amount of the position of the transmitter.

Abstract: An apparatus includes an imaging probe and is configured for dynamically arranging presentation of visual feedback for guiding manual adjustment, via the probe, of a location, and orientation, associated with the probe. The arranging is selectively based on comparisons between fields of view of the probe and respective results of segmenting image data acquired via the probe. In an embodiment, the feedback does not include a grayscale depiction of the image data. Coordinate system transformations corresponding to respective comparisons may be computed. The selecting may be based upon and dynamically responsive to content of imaging being dynamically acquired via the probe.

Abstract: A method comprises providing a current state image and at least one reference image, taken from a similar angle range. The image and the at least one reference image are superimposed and a visual representation visualizing the relation between the image and the reference image is provided in order to track displacements of the bone during subsequent operation steps. A system is provided which can use the image data to track displacements and determine deviation from a current state of the elements in question to a target state.

Abstract: Provided is an optical tracking tool for navigating a surgery, comprising a mounting base. The mounting base is provided with two to six supporting faces thereon. Two or four reflective balls are arranged on each of the supporting faces. A positioning surface is formed by the four reflective balls located on the same supporting face or the four reflective balls respectively located on two adjacent supporting faces. An included angle between surface normal vectors of two adjacent positioning surfaces is 90°-140°. As compared with a tracking tool having a single positioning surface formed by four reflective balls in the prior art, the optical tracking tool can considerably broaden an effective tracking range of a system, thereby improving system accuracy.

Abstract: A system (100) for tracking the position and orientation (i.e., the pose) of a medical imaging device (210) is described. The system determines in real time the pose of an imaging medical device based on a combination of image data and sensor data obtained from an imaging medical device and tracking sensors (210) associated with the device. Pose is determined based on a calculated tracking pose change and a calculated image pose change and a determined reliability of the calculated tracking pose change and the calculated image pose change.

Abstract: The present disclosure relates to the field of a cabinet x-ray incorporating an x-ray tube, an x-ray detector, and a near-infrared optical system mounted onto the cabinet or positioned within the cabinet, for the production of organic and non-organic images. The computing device receives video data from the near-infrared optical system and determines, based on the video data an optical image displaying the captured real-time image or display images adjacently i.e. Picture-In-Picture (PIP). In particular, the present disclosure also relates to a system and method with corresponding apparatus for capturing a near-infrared image simultaneously with the x-ray image allowing a cabinet x-ray unit to attain and optimize images utilizing near-infrared (NIR) fluorescence for sentinel lymph node (SLN) mapping in breast cancer patients to improve the Sentinel Lymph Node identification and procedure.

Abstract: A computer implemented method and a system for registering and tracking an anatomical structure of a patient. A method includes acquiring a first stereoscopic image dataset including video images having different viewing angles, and providing a first image content showing the anatomical structure; registering the first image dataset to a 3D image dataset showing the anatomical structure; acquiring a second stereoscopic image dataset comprising video images having different viewing angles and providing a second image content showing the anatomical structure, which differs from the first image content; and tracking the anatomical structure based on the second image dataset.

Abstract: A medical securing, such as a suturing device (100) for securing a cardiac implant device (400A, 400B) with a securing member (102), like a suture. The medical securing device comprises an elongated sheath (101) extending in a longitudinal direction and having proximal (101A) and distal (101B) ends. The distal end of the elongated sheath has a support portion (101C) to support the elongated sheath to the cardiac implant device and/or to the tissue (20). The medical securing device comprises also a securing member introduction device (103) extending from the sheath (101) and having proximal (103A) and distal (103B) ends. The distal end (103B) of the securing member introduction device (103) is configured to deliver the securing member (102) to the cardiac implant device and to secure the cardiac implant device to the annulus (20) of the valve with the securing member (102).

Abstract: Described embodiments include an apparatus that includes an expandable structure, configured for insertion into a body of a subject, and a plurality of conducting elements coupled to the expandable structure. Each of the conducting elements comprises a respective coil and has an insulated portion that is electrically insulated from tissue of the subject, and an uninsulated portion configured to exchange signals with the tissue, while in contact with the tissue. Other embodiments are also described.

Abstract: A method and system implementing a method for detecting a catheter in fluoroscopic data and updating a displayed electromagnetic position of the catheter on a 3D rendering is provided including navigating a catheter to a target area and acquiring fluoroscopic data from a fluoroscopic sweep of the target area. An initial catheter detection is performed to detect catheter tip candidates in each 2D frame of the fluoroscopic data using a shallow neural network. A secondary catheter detection is performed to detect catheter tip candidates in each 2D frame of the fluoroscopic data using a deep neural network. False-positive catheter tip candidates are removed by reconstructing a 3D position of the catheter tip and finding an intersecting point of rays corresponding to each 2D frame.

Abstract: A method for manufacturing an implantable access port, including forming a port body. The port body can include a fluid cavity located in a central region, the fluid cavity having a base surface lying in a first plane, and a plurality of recessed sections located in a peripheral region surrounding the central region, the plurality of recessed sections having a depth extending from a bottom surface of the peripheral region through the first plane. The method further includes locating a septum over the fluid cavity, and positioning a radiopaque insert in the plurality of recessed sections.

Abstract: Novel systems and methods for airway segmentation are disclosed using confident airway volume, multi-scale topological and geometric leakage detection, exact leakage localization and correction, forbidden volume insertion and freezing, iterative shift in growing techniques starting with a conservative parameter/strategy and progressing toward generous ones, and a final pruning using machine learning, neural network, deep learning or artificial intelligence methods. The systems and methods are fully automated requiring no manual inputs or post-editing steps. The systems and methods use region growing-based segmentation to iteratively grow an airway tree starting with an initial seed, possibly inside the trachea, and a conservative segmentation parameter, e.g., a conservative threshold value for intensity-based region growing. The method then gradually progresses toward more generous values of the segmentation parameters until there is convergence.

Abstract: An image acquisition unit acquires a plurality of projection images corresponding to a plurality of radiation source positions at the time of tomosynthesis imaging, the plurality of projection images being generated by causing an imaging apparatus to perform tomosynthesis imaging in which radiation is emitted to a subject. A structure position specifying unit specifies one structure position in the subject. A display controller specifies projection positions of the structure position in the plurality of projection images, and performs switching display of the plurality of projection images on a display unit so that the projection positions match a predetermined position on the display unit.

Abstract: A tracking system can be used to track a plurality of tracking devices. A representation of at least two instruments may be displayed relative to image data. The representation is customizable to distinguish between the at least two instruments.

Abstract: Medical devices are disclosed having improved visualization of a portion of the medical device insertable into a patient's body while minimizing obstruction of fluid flow through a lumen of the device and while minimizing an increase in the outer diameter of the device attributable to the feature providing improved visualization. The device can include, for example, an imaging marker distal to lumen openings (exit ports), or, where the device comprises a tube, such as a metallic tube, an imaging marker embedded into a wall of the tube. Another embodiment includes attaching a marker to the surface on the inside of a lumen of a medical device without embedding the marker. Various alternative embodiments, methods and applications of using such devices are disclosed as well.

Abstract: A physiological signal processing device is provided. The physiological signal processing device includes a patch, a plurality of electrodes and a processing device. The plurality of electrodes detect an Electrocardiography (ECG) signal. The processing device is configured in the patch and is coupled to the plurality of electrodes to receive the ECG signal. Furthermore, according to the ECG signal, the processing device calculates a first differential value between a voltage of an R wave of the ECG signal and a reference ECG value, and determines whether the first differential value is greater than or equal to a first threshold to determine whether to adjust the positions of the electrodes. When the positions of the electrodes are determined, the processing device obtains heartbeat information and/or breathing information according to the ECG signal.

Abstract: An ultrasound diagnosis apparatus generates an ultrasound image of an inside of a subject on a basis of ultrasound signals which are reflected off at the inside of the subject and received. The apparatus includes a needle position specifier and a needle emphasis processor. With respect to each region in the ultrasound image, the needle position specifier obtains a deep region feature value relating to signal intensity in a region deeper than a region subject to judgment in relation to ultrasound signal distribution along an emission direction of an ultrasound emitted in a subject, and specifies a position of a puncture-needle which is inserted in the subject. The needle emphasis processor carries out a process for emphasizing the position of the puncture-needle which is specified in the ultrasound image.

Abstract: A calibration device for a computer-assisted surgical instrument includes a rigid body, stabilization members, and references structurally or mechanically complementary to the stabilization members and disposed on opposite sides of a manipulator of the instrument. Kinematic state of the manipulator is defaulted when the calibration device is connected to the instrument by the stabilization members passing through the rigid body and removably attaching to the references. A calibration method for a computer-assisted surgical instrument implemented by a computer system includes the steps of: prompting a user to connect the calibration device to the instrument; determining if the calibration device is properly connected to the instrument; and generating default kinematic information of the manipulator of the instrument if the calibration device is properly connected to the instrument. The calibration device and method effectively improve accuracy and precision of computer-assisted surgeries.