Combined With Therapeutic Or Diagnostic Device Patents (Class 600/427)
  • Patent number: 10888381
    Abstract: A registration apparatus registers an elongated introduction element (18), like a catheter or a needle, during an interventional procedure, for instance, a brachytherapy or a biopsy. A guide element (13) includes at least one opening which guides the introduction element when being introduced into a living being (2) through the opening. A temperature profile generation element (14) associated with the opening generates a characteristic temperature profile at the opening for being transferred to the introduction element when being present in the opening. A temperature determination unit (15) determines a temperature along the introduction element, and a registration unit (16) registers the introduction element. The registering includes identifying the transferred characteristic temperature profile on the introduction element based on the determined temperature. This allows the registration unit to register the introduction element during the introduction process in a simple and efficient manner.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: January 12, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Guillaume Leopold Theodoros Frederik Hautvast, Dirk Binnekamp, Shyam Bharat, Ehsan Dehghan Marvast, Jochen Kruecker, Molly Lara Flexman, Amir Mohammad Tahmasebi Maraghoosh
  • Patent number: 10870019
    Abstract: The invention relates to a system for delivering a radiation treatment to a structure (21) within a body. In the system, a plurality of treatments plans is provided, each treatment plan being associated to one of a plurality of predefined possible position (33a; 33b) of the structure (21), which area regularly distributed on at least one predefined surface (32a; 32b). A control unit is configured to determine the position of the structure during the treatment and to select a treatment plan which is associated with a predefined possible position having a smallest distance to the determined position, for controlling the radiation source in response to the detection of the position. Moreover, the invention relates to a computer program for controlling the system and to a planning unit for generating the treatment plans.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: December 22, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Davide Fontanarosa, Alfonso Agatino Isola
  • Patent number: 10849789
    Abstract: An ophthalmic measurement and laser surgery system includes: a laser source; a corneal topography subsystem; an axis determining subsystem; a ranging subsystem comprising an Optical Coherence Tomographer (OCT); and a refractive index determining subsystem. All of the subsystems are under the operative control of a controller. The controller is configure to: operate the corneal topography subsystem to obtain corneal surface information; operate the axis determining subsystem to identify one or more ophthalmic axes of the eye; operate the OCT to sequentially scan the eye in a plurality of OCT scan patterns, the plurality of scan patterns configured to determine an axial length of the eye; operate the refractive index determining subsystem so to determine an index of refraction of one or more ophthalmic tissues, wherein at least one of the corneal surface information, ophthalmic axis information, and axial length is modified based on the determined index of refraction.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: December 1, 2020
    Assignee: AMO Development, LLC
    Inventors: David A. Dewey, Javier G. Gonzalez, Georg Schuele, David D. Scott
  • Patent number: 10842461
    Abstract: A system and method of checking registration for a surgical system, the surgical system including fiducials and tracking markers, may include: using the fiducials and the tracking markers to register a three-dimensional (3D) imaging space of the surgical system with a 3D tracking space of the surgical system; using a tracking fixture of an X-ray imaging system to register an X-ray imaging space of the X-ray imaging system to the 3D tracking space; obtaining a two-dimensional (2D) X-ray image corresponding to the 3D tracking space; identifying a point of interest in the 2D X-ray image; determining a vector in the 3D tracking space that passes through the point of interest; and/or evaluating the registration of the 3D imaging space with the 3D tracking space based on a location, an orientation, or the location and the orientation of the vector in the 3D tracking space.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: November 24, 2020
    Assignee: Globus Medical, Inc.
    Inventors: Norbert Johnson, Neil Crawford, Jeffrey Forsyth
  • Patent number: 10842349
    Abstract: An endoscope operation support system includes: an image display unit which, transmits external scenery and allows the user to visually recognize the external scenery, and also displays a virtual image as superimposed on the external scenery and allows the user to visually recognize the virtual image; a control unit which controls the image display unit; an endoscope unit having an image pickup unit at a distal end part inserted in an image pickup target part of an object, the image pickup unit picking up an image inside the image pickup target part; and a position detection unit which detects a position of the distal end part. The control unit causes the image display unit to display a position display image including a pointer image indicating the position of the distal end part detected by the position detection unit, as the virtual image superimposed on the object in the external scenery.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: November 24, 2020
    Assignee: SEIKO EPSON CORPORATION
    Inventors: Akio Yamazaki, Yuichi Mori
  • Patent number: 10786310
    Abstract: An electromagnetic (“EM”) tracking configuration system employs an EM quality assurance (“EMQA”) (30) and EM data coordination (“DC”) system (70). For the EMQA system (30), an EM sensor block (40) includes EM sensor(s) (22) positioned and oriented to represent a simulated electromagnetic tracking of interventional tool(s) inserted through electromagnetic sensor block (40) into an anatomical region. As an EM field generator (20) generates an EM field (21) encircling EM sensor(s) (22), an EMQA workstation (50) tests an EM tracking accuracy of an insertion of the interventional tool(s) through the EM sensor block (40) into the anatomical region.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: September 29, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Shyam Bharat, Ehsan Dehghan Marvast, Cynthia Ming-Fu Kung, Amir Mohammad Tahmasebi Maraghoosh, Sandeep M. Dalal, Jochen Kruecker, Antonio Bonillas Vaca, Douglas Allen Stanton
  • Patent number: 10786312
    Abstract: Systems, methods and devices are disclosed for use in electronic guidance systems for surgical navigation. A sensor is provided with an optical sensor and an inclinometer (e.g. accelerometer or other inclination measuring sensor) and communicates measurements of patient inclination to an inter-operative computing unit. A registration device is useful to construct a registration coordinate frame. The direction of gravity may be used to construct the registration coordinate frame such as determined from inclination measurements.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: September 29, 2020
    Assignee: INTELLIJOINT SURGICAL INC.
    Inventors: Richard Tyler Fanson, Eric Ryterski, Armen Garo Bakirtzian, Andre Novomir Hladio
  • Patent number: 10776988
    Abstract: Systems and methods are disclosed for integrating imaging data from multiple sources to create a single, accurate model of a patient's anatomy. One method includes receiving a representation of a target object for modeling; determining one or more first anatomical parameters of the target anatomical object from at least one of one or more first images of the target anatomical object; determining one or more second anatomical parameters of the target anatomical object from at least one of one or more second images of the target anatomical object; updating the one or more first anatomical parameters based at least on the one or more second anatomical parameters; and generating a model of the target anatomical object based on the updated first anatomical parameters.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: September 15, 2020
    Assignee: HeartFlow, Inc.
    Inventors: Leo Grady, Michiel Schaap
  • Patent number: 10772581
    Abstract: A radiation tomograph whereby the acquisition of transmission data and the measurement of annihilation radiation pairs are simultaneously performed by a single detector ring so as to realize both reduction of the manufacturing cost of a PET device and reduction of a burden to a subject. The transmission data, which shows the distribution of annihilation radiation absorption characteristics within a subject, is computed from data relating to annihilation radiation pairs in the vicinity of a surface of the subject. The transmission data can be acquired by detecting a radioactive drug derived from the subject, which makes imaging exclusively for transmission data unnecessary.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: September 15, 2020
    Assignee: Shimadzu Corporation
    Inventors: Tomoaki Tsuda, Tetsuya Kobayashi
  • Patent number: 10758200
    Abstract: A method and a corresponding system for assessing a haemodynamic parameter for a vascular region of interest of a patient based on angiographic images are provided. After acquiring multiple angiographic images, a three dimensional (3D) representation of at least a first portion of the respective region of interest is performed, and geometric features are extracted from complete or partial views. Additional geometric features are extracted from partial incomplete views. A complete set of 3D geometric features for an anatomical structure, such as a vessel tree, is then generated by combining the extracted geometric features and estimating any missing geometric features. Using the complete set of 3D geometric features, a feature-based assessment of the haemodynamic parameter, such as a fractional flow reserve, is then performed.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: September 1, 2020
    Assignee: Siemens Healthcare GmbH
    Inventors: Tiziano Passerini, Lucian Mihai Itu, Thomas Redel, Puneet Sharma
  • Patent number: 10758745
    Abstract: Systems and methods for generating a radiation therapy treatment plan by using ultrasound images are disclosed. The method includes obtaining a first set of image data representing a first image of an anatomical region that includes a treatment applicator inserted into the anatomical region. The method further includes receiving tracking information indicating a position of the treatment applicator as represented in the first set of image data, obtaining a second set of image data representing a second image of the anatomical region, and combining at least a portion of the first set of image data with the second set of image data. One of the first set and the second set of image data is used to identify a target tissue portion in the anatomical region. The method further includes generating, based on the combined image data, treatment plan information for treating the target tissue portion in the anatomical region.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: September 1, 2020
    Assignee: NUCLETRON OPERATIONS B.V.
    Inventors: Cor Van de Wardt, Paulus Cornelis Hendrikus Maria Krechting, Jan Frans Lodewijk De Becker, Nicole Nesvacil, Christian Kirisits, Richard Pötter, Maximilian Paul Schmid
  • Patent number: 10751030
    Abstract: The present application relates to an ultrasound fusion imaging method and an ultrasound fusion image navigation system. The ultrasound fusion imaging method includes a selection step, a registration step and a fusion step. The selection step is for selecting at least one ultrasound image from at least one previously stored piece of ultrasound video data according to an input instruction. The ultrasound video data includes an ultrasound image obtained by acquiring a target object in at least one plane and position indicating information corresponding to the ultrasound image. The registration step is for registering the selected at least one ultrasound image with a modality image. The registration process uses the location of the position indicating information of the at least one ultrasound image. The fusion step is for fusing the registered ultrasound image with the modality image.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: August 25, 2020
    Assignees: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD., TSINGHUA UNIVERSITY
    Inventors: Jingang Kang, Guangzhi Wang, Lei Zhu, Qian Zhang, Hui Ding, Minglei Yang, Longfei Cong
  • Patent number: 10755452
    Abstract: A method of calibrating time in a Positron Emission Tomography (PET) device includes obtaining original time information and energy information of a first pulse signal collected by a detecting module during a scanning process of the PET device. A detector of the PET device includes a plurality of detecting modules. The original time information of the first pulse signal includes a moment at which an amplitude of the first pulse signal begins to be greater than a threshold. The method includes determining a pulse time calibration amount corresponding to the energy information of the first pulse signal according to stored information indicative of a correspondence between the pulse time calibration amount and the energy information of each detecting module. The method includes generating calibrated time information of the first pulse signal by calibrating the original time information with the pulse time calibration amount; and reconstructing a PET image based on the generated calibrated time information.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: August 25, 2020
    Assignee: Shanghai Neusoft Medical Technology Co., Ltd.
    Inventors: Xi Wang, Jian Zhao, Guocheng Wu, Baowei Xu, Guodong Liang
  • Patent number: 10743757
    Abstract: An ultrasonic transducer includes a piezoelectric element in round shape, an acoustic lens, and an acoustic matching layer. The piezoelectric element generates an ultrasonic sound wave. The acoustic matching layer decreases a reflection of the ultrasonic sound wave from a subject. The piezoelectric element has a center having a hole through which an optical fiber that guides a light of a light source passes. The ultrasonic transducer transmits and receives the ultrasonic sound wave while emitting the light. The acoustic lens has a material using a resin with a withstand voltage, mainly polymethylpentene. The acoustic matching layer has a thickness set to ?/4 by not applying a polyparaxylylene coating for ensuring the withstand voltage on the acoustic matching layer. The optical fiber has a distal end configured not to pass through the acoustic lens. The piezoelectric element and the acoustic matching layer have shapes in a planar surface.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: August 18, 2020
    Assignee: NIHON DEMPA KOGYO CO., LTD.
    Inventors: Kazuhiko Komiyama, Yasunobu Hasegawa
  • Patent number: 10722730
    Abstract: System includes a beam generator to generate beam(s) for patient treatment and a computing device that obtains three-dimensional image(s) of a target structure that repositions with respect to surrounding tissue of the patient. The computing device creates plan(s) including a first three-dimensional probability distribution of patient's position and a second three-dimensional probability distribution of the repositioned structure's internal position. The computing device combines the first distribution with the second distribution to generate a joint distribution and selects a probability level from the joint distribution. The probability level defines an enclosed surface. A distance defined between the surface and a point of origin in at least one direction is equal to a threshold value of a parameter of the repositioned target in the direction.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: July 28, 2020
    Assignee: Varian Medical Systems International AG
    Inventors: Anssi Kesti-Helia, Sampsa Lappalainen, Timo K. Koponen, Perttu Niemela
  • Patent number: 10716676
    Abstract: An apparatus and modeling method of the present invention includes the successive steps of generating cartographic data representative of points belonging to a glenoid surface; distinguishing from among the cartographic data a first group of cartographic data corresponding to a first part of the glenoid surface, the first surface part being situated farthest down in the vertical direction in relation to the scapula; calculating from the first group of cartographic data a first ellipsoid portion that coincides substantially with the first surface part; and obtaining a theoretical glenoid surface from the first ellipsoid portion. By virtue of the theoretical glenoid surface obtained by this method, it is possible to assist the surgeon in optimizing the position of implantation of a glenoid component and to produce a glenoid component “made to measure” for the scapula that is to be fitted with a prosthesis.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 21, 2020
    Assignee: Tornier SAS
    Inventors: Alain Tornier, Delphine Claire Michelle Henry
  • Patent number: 10702712
    Abstract: Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions for causing the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: July 7, 2020
    Assignee: ACCURAY INCORPORATED
    Inventors: Calvin R. Maurer, Jay West, Petr Jordan
  • Patent number: 10706540
    Abstract: Methods and systems for registering three-dimensional (3D) CT image data with two-dimensional (2D) fluoroscopic image data using a plurality of markers are disclosed. In the methods and systems, a lateral angle and a cranial angle are searched for and a roll angle is computed. 3D translation coordinates are also computed. The calculated roll angle and 3D translation coordinates are computed for a predetermined number of times successively. After performing the calculations, the 3D CT image data is overlaid on the 2D fluoroscopic image data based on the lateral angle, the cranial angle, the roll angle, and the 3D translation coordinates.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: July 7, 2020
    Assignee: COVIDIEN LP
    Inventor: Nicolas J. Merlet
  • Patent number: 10702342
    Abstract: A method and system for determining a target location for a medical device having complex geometry relative to an anatomical feature, and for navigating and positioning the medical device at the target location. The system may include a medical device including a treatment element having a centroid, one or more navigation electrodes, and a longitudinal axis and a navigation system in communication with the one or more navigation electrodes, the navigation system including a processing unit. The processing unit may be programmed to define a plane that approximates a surface of the anatomical feature, define a centroid of the anatomical feature, define a vector that is normal to the plane and extends away from the centroid of the anatomical feature, and determine a target location for the treatment element of the medical device based on the vector to assist the user in placing the device for treatment.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: July 7, 2020
    Assignee: Medtronic, Inc.
    Inventor: Scott A. Hareland
  • Patent number: 10706565
    Abstract: A multi-dimensional solution directed to employment of a low-resolution motion tracking technique to estimate a homogeneous transformation matrix that is further adapted to accurately characterize movement/motion between successive positions of an object through time. Low-resolution tracking is first used to estimate a homogeneous transformation matrix that describes the motion between successive positions of an object as that object moves over time. The 3-dimensional imaging data is then used to calculate a more accurate homogeneous transformation matrix, providing the accuracy to better characterize motion of the object over time. In the case where the ‘object’ being tracked is a 3-dimensional imaging system (herein, 3DIS), the resulting homogeneous transformation matrix is used to create 3-dimensional digital models of the scene that is in the field-of-view of the 3-dimensional imaging system (3DIS).
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: July 7, 2020
    Assignee: Seikowave, Inc.
    Inventors: Matthew W Bellis, Eli Ross Crane
  • Patent number: 10695586
    Abstract: Disclosed herein are radiation therapy systems and methods. These radiation therapy systems and methods are used for emission-guided radiation therapy, where gamma rays from markers or tracers that are localized to patient tumor regions are detected and used to direct radiation to the tumor. The radiation therapy systems described herein comprise a gantry comprising a rotatable ring coupled to a stationary frame via a rotating mechanism such that the rotatable ring rotates up to about 70 RPM, a radiation source (e.g., MV X-ray source) mounted on the rotatable ring, and one or more PET detectors mounted on the rotatable ring.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: June 30, 2020
    Assignee: RefleXion Medical, Inc.
    Inventors: Brent Harper, Robert Wiggers, David Larkin, David Meer, David Nett, Rostem Bassalow, Peter Olcott, Chris Julian, Brent Dolan, William Jorge Pearce
  • Patent number: 10695584
    Abstract: Provided is a method for measuring a depth profile of a particle beam, the method including providing first sensors in a first direction in auditory organs of a human body, providing second sensors in a second direction that intersects with the first direction on a top of a head and in a mouth of the human body, providing a particle beam into the head of the human body, detecting an acoustic signal generated by the particle beam through the first and second sensors, and calculating a depth profile of the first and second directions of the particle beam corresponding to a Bragg peak position of the particle beam in the head using the acoustic signal.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: June 30, 2020
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Dong-Ho Shin, Moon Youn Jung, Seunghwan Kim
  • Patent number: 10695130
    Abstract: A dose planning system includes a biopsy map creation module configured for receiving biopsy information for an organ of interest regarding biopsy locations and tissue characteristics of tissue found at the biopsy locations and creating a spatially annotated biopsy map for the organ, by linking the spatial information on the biopsy locations to the tissue characteristics of tissue found at the corresponding biopsy locations. A probability map calculation module is configured for creating a tumor probability map by calculating a tumor probability for locations in the organ from which no biopsy was taken by using the tumor and/or tissue characteristics from the biopsy locations and a dose planning module configured for creating a dose plan based on the tumor probability map. The planning constraints are such that on average a higher tumor probability results in a higher planned dose and a lower tumor probability results in a lower planned dose.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 30, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jacek Lukasz Kustra, Guillaume Leopold Theodorus Frederik Hautvast
  • Patent number: 10688318
    Abstract: The radiographic imaging apparatus is configured so that an irradiation device is mounted on a rotary drum of a rotary gantry. A pair of X-ray sources is disposed outside the rotary drum and attached to the outer surface of the rotary drum. A pair of FPDs facing the respective X-ray sources is mounted in the irradiation device. When X-rays are irradiated, X-ray intensity information is calculated by a signal processing device based an output signal from each radiation detection element of each FPD, and stored in a memory. Based on FOV information set by an input device, an X-ray intensity acquisition device acquires multiple pieces of X-ray intensity information that are calculated based on the output signals from the radiation detection elements in small FOV areas (or large FOV areas) of the FPDs, which are included in the X-ray intensity information stored in the memory.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: June 23, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Shinichirou Ie, Norihiro Uemura, Keigo Takeuchi
  • Patent number: 10667948
    Abstract: A device for protecting tissue when treating an eye using a laser beam generated by a laser system and deflected by a scanner system comprises an eye model, a control data module and a processor. The eye model comprises eye data which define dimensions and locations of eye structures. The control data module is configured to register control data which define beam parameters of the laser beam and a scanning pattern for the laser beam. The processor is configured to simulate by computation a light spot moving on or in an eye structure on the basis of the eye data and the control data, to add up, for a plurality of measurement points of the eye structure and continuously, a beam dose emitted at the relevant measurement point by the moving light spot and to generate an emergency signal if a dose limit Dmax is exceeded at one of the measurement points.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: June 2, 2020
    Assignee: Ziemer Ophthalmic Systems AG
    Inventor: Christian Rathjen
  • Patent number: 10667742
    Abstract: Breast monitoring systems and methods are described including a flexible substrate fabricated to substantially conform to one or more breasts of a subject; dynamically bendable optical fibers associated with the flexible substrate; a light source operably coupled to the optical fibers; a photodetector positioned to detect light reception from the optical fibers; a reporting device; and a microcontroller including a microprocessor and circuitry, wherein the circuitry includes input circuitry configured to receive a first set of signals and at least one second set of signals from the photodetector; calculation circuitry configured to calculate a curvature delta value based on a comparison of the received first and at least one second set of signals, and calculate a breast volume delta value from the calculated curvature delta value; and reporting circuitry configured to transmit a signal to the reporting device based on the calculated breast volume delta value.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: June 2, 2020
    Assignee: Elwha LLC
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Wayne R. Kindsvogel, Elizabeth A. Sweeney, Charles Whitmer
  • Patent number: 10660580
    Abstract: Radiographic imaging systems and/or methods embodiments capable of both tomosynthesis x-ray imaging and general projection radiography x-ray imaging can include a single x-ray source assembly including a plurality of distributed x-ray sources, where at least one of the plurality of distributed x-ray sources is configured to output a beam sufficient for standard projection radiography, and each of at least two of the plurality of distributed x-ray sources is configured to output a beam at a lower radiation dose sufficient for tomosynthesis. In one embodiment, radiographic imaging systems and/or methods embodiments can include a single x-ray source; a first collimator that is configured to be adjustable for at least two dimensions; and a second collimator that is configured to provide fixed collimation. In one embodiment, a single x-ray source can include a single radiation shield or a single vacuum chamber.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: May 26, 2020
    Assignee: Carestream Health, Inc.
    Inventors: Michael D. Heath, Xiaohui Wang, David H. Foos
  • Patent number: 10665624
    Abstract: The invention provides a linear sensor including a row 100 of N regularly spaced pixels that are formed in a semiconductor substrate, and a circuit for reading out the N pixels, which delivers an output signal for each of the N pixels of the row, characterized in that the N pixels comprise image-capturing pixels that have a useful photosensitive area in the shape of a rectangle R that is higher than it is wide, where the width is in the direction of the row and the height is in the perpendicular direction, and at least two spaced-apart pairs of alignment-detecting pixels PPL, PPR, wherein the detecting pixels of each pair are pixels P1, P2 that are adjacent in the row 100 of pixels and the useful photosensitive area DT1, DT2 of the detecting pixels has a width that varies monotonically in the height direction, but in opposite directions for the two detecting pixels of a given pair.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: May 26, 2020
    Assignee: TELEDYNE E2V SEMICONDUCTORS SAS
    Inventors: Thierry Ligozat, Bruno Gili, Romain Guiguet, Franck Tellier, Norman Mangeret
  • Patent number: 10653803
    Abstract: Living cells, such as red blood cells (RBCs) modified with functional micromotors with the aid of ultrasound propulsion and magnetic guidance. Iron oxide nanoparticles are loaded into the RBCs, where their asymmetric distribution within the cells results in a net magnetization, thus enabling magnetic alignment and guidance under acoustic propulsion. The RBC motors display efficient guided and prolonged propulsion in various biological fluids, including undiluted whole blood.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: May 19, 2020
    Assignee: The Regents of the University of California
    Inventors: Joseph Wang, Liangfang Zhang
  • Patent number: 10646279
    Abstract: The invention relates to an imaging apparatus (24) for imaging an introduction element (17) like a needle or a catheter for performing a brachytherapy or a biopsy. A tracking unit (3, 4) tracks the location of the introduction element within a living being (2), an imaging unit (6) like an ultrasound imaging unit generates an image showing an inner part of the living being, which includes the tracked location of the introduction element, based on the tracked location, and a display (7) displays the image. During the brachytherapy or biopsy the display can always show the introduction element, without requiring a manual control. For instance, it is not necessary that a physician manually controls the position and image plane of the imaging unit. This allows for an accurate and fast insertion of the introduction element into the living being such that a target region is reliably reached.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: May 12, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Amir Mohammad Tahmasebi Maraghoosh, Shyam Bharat, Ehsan Dehghan Marvast, Vijay Parthasarathy
  • Patent number: 10639233
    Abstract: The treatment of various sensitive organs with low energy acoustic shockwaves has been proposed. However, the prior art is lacking in guidance as to what constitutes an efficacious minimum dosage or a safe maximum dosage for various target organs and tissues. Through extensive experimentation with cultured cells, live animals, and animal disease models, the inventors of the present disclosure have determined safe and efficacious shockwave energetic dosage ranges for vital and sensitive organs, including the brain, pancreas, kidneys, liver, and spleen, as well as for skin and subcutaneous tissues, peripheral nerves, and skeletal muscles.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: May 5, 2020
    Assignee: The Regents of the University of California
    Inventors: Tom Lue, Ching-Shwun Lin, Guiting Lin, HongXiu Ning
  • Patent number: 10634752
    Abstract: In various embodiments, the present application discloses systems and methods for magnetic resonance imaging (MRI) of coronary arteries. In various embodiments, the invention allows for motion corrected, simultaneously acquired multiple contrast weighted images with whole-heart coverage and isotropic high resolution. In some embodiments, the invention teaches using interleaved preparatory pulses, a 3D radial golden angle trajectory and 100% respiratory gating efficiency.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: April 28, 2020
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Debiao Li, Yibin Xie, Jianing Pang, Qi Yang
  • Patent number: 10624623
    Abstract: A lateral retractor system for forming a surgical pathway to a patient's intervertebral disc space includes a single dilator and a retractable dual-tapered-blade assembly. The single dilator may feature a narrow rectangular body for insertion at an insertion orientation parallel to the fibers of the patient's psoas muscle and at an approximate 45-degree angle to the patient's spine. The retractable dual-tapered-blade assembly consists of only two blade subassemblies, each having a blade bordered by adjustable wings, along with built-in video capabilities and lighting control for illuminating the surgical pathway. The dual-tapered-blade assembly may be passed over the single dilator at the insertion orientation and rotated approximately 45-50 degrees from the insertion orientation to a final rotated orientation parallel to the intervertebral disc space before the two blade subassemblies are retracted away from one another to create the surgical pathway. Other embodiments are also disclosed.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: April 21, 2020
    Inventor: Edward Rustamzadeh
  • Patent number: 10610098
    Abstract: Embodiments of the present invention provide a system and method to automatically screen images from a plurality of fundus cameras for a plurality of retinal diseases. The system comprises stacked autoencoders, amplitude modulation-frequency modulation filters, and artificial neural networks. An embodiment of the present invention uses a multi-class classifier, such as a support vector machine (multi-class SVM) classifier, to determine a plurality of retinal pathologies. An exemplary embodiment of the present invention is validated on a proprietary database of thousands of images (for example over 250,000 retinal images) from multiple cameras, ranging from the table-top fundus cameras to portable hand-held cameras.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: April 7, 2020
    Assignee: VISIONQUEST BIOMEDICAL LLC
    Inventors: Peter Soliz, Jeremy Benson, Trilce Estrada
  • Patent number: 10610315
    Abstract: A system comprises a teleoperational assembly including an operator control system and a plurality of manipulators configured for teleoperation by the operator control system. A first manipulator of the plurality of manipulators is configured to control movement of a first medical instrument in a surgical environment. The system further comprises a processing unit configured to display an image of a field of view of the surgical environment; determine first association information for the first medical instrument, the first association information including information about at least one of the first manipulator or the operator control system; display a first badge proximate to an image of the first medical instrument in the image of the field of view, the first badge including the first association information; and adjust a size of the first badge as the first medical instrument changes depth relative to an imaging instrument capturing the field of view.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: April 7, 2020
    Assignee: INTUITIVE SURGICAL OPERATIONS, INC.
    Inventors: Brandon D. Itkowitz, Paul W. Mohr
  • Patent number: 10602971
    Abstract: A biological information detection device according to an aspect of the present disclosure includes: a light source that, in operation, emits irradiation light for irradiating a test portion of a subject; a light detector that, in operation, detects light reached from the test portion and that outputs an electrical signal corresponding to the light; and a calculation circuit that, in operation, generates a signal of biological information related to a blood flow in a target area in the test portion based on the electrical signal. The light detector is an image sensor. The electrical signal includes an image signal obtained by the image sensor. The calculation circuit, in operation, detects a magnitude of an inclination of an orientation of the test portion with respect to a reference orientation by image recognition based on the image signal, and determines the target area according to the magnitude of the inclination of the orientation of the test portion.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: March 31, 2020
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Naomi Satoi, Teruhiro Shiono, Toshiya Fujii
  • Patent number: 10588585
    Abstract: One aspect of the present disclosure relates to a system that can employ multi-modal imaging to provide an image with an enhanced resolution. In some instances, the multi-modal imaging can allow an operator to determine and control a tissue margin without the need for intra-operative tissue pathology. The system can include an imaging system that includes a gamma camera to detect a gamma image and an optical imaging modality to detect an optical image. The system can also include a display device to display an enhanced gamma image created based on a function of the optical image. The enhanced gamma image illustrates a characteristic of a disease in the field of view (e.g., a lymphatic pathway, a sentinel lymph node target, or a satellite disease state).
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: March 17, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Yang Liu, Francis A. Papay
  • Patent number: 10583069
    Abstract: The present invention relates to a method for treating the kidney with extracorporeal shockwaves in a noninvasive manner and in particular, to such a method for the treatment of the nephrons about the glomerulus.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: March 10, 2020
    Inventor: Avner Spector
  • Patent number: 10583310
    Abstract: An implant planning system aids delivery of radiation to tumor sites of a patient. The system allows a user to test various combinations of virtual implants, each associated with a corresponding physical implant (e.g., a carrier with an embedded radioactive seed), and to view the dosage area of the virtual implants so that adjustments to the virtual implants may be made until a prescribed dose of radiation to a treatment area is achieved. A treatment plan developed based on the virtual implants may then be used in surgical implantation of the corresponding physical implants. For example, the implant configuration of the treatment plan may be projected onto a treatment surface of a patient, such as in a surgical room, so that physical implants may be placed according to the projected image of the virtual implants.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: March 10, 2020
    Assignee: GT MEDICAL TECHNOLOGIES, INC.
    Inventors: Evan K. Fram, David Brachman
  • Patent number: 10555706
    Abstract: To generate images, in which a first row area of a multiple-row detector is illuminated with a first X-ray spectrum and a second row area of the multiple-row detector, trailing in the direction of travel, is illuminated with a second X-ray spectrum, image data is recorded at a pitch chosen such that one slice image can be reconstructed in each case for a sectional position for the first and the second row area. Correspondingly, for the sectional position, the respective slice image for the first and the second row area is reconstructed. For a third row area, illuminated with the first and the second X-ray spectrum, a reference sectional image is reconstructed as a slice image. To generate motion-reduced first and second spectral images assigned to the first and second row area respectively, the slice images of the first and second row areas are registered to the reference sectional image.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: February 11, 2020
    Assignee: SIEMENS HEALTHCARE GMBH
    Inventors: Bernhard Krauss, Bernhard Schmidt, Karl Stierstorfer, Eric Fournie, Markus Juergens
  • Patent number: 10548479
    Abstract: A system for imaging and quantifying shear wave and shear modulus under orthogonal acoustic radiation force (ARF) excitation using the OCT Doppler variance apparatus. The ARF perpendicular or with at least a perpendicular component to the OCT beam is produced by a remote ultrasonic transducer. The OCT Doppler variance apparatus, which is sensitive to the transverse vibration, is used to measure the ARF induced vibration. For analysis of the shear modulus, the Doppler variance apparatus is utilized to visualize shear wave propagation. The propagation velocity of the shear wave is measured and then used to quantitatively map the shear modulus.
    Type: Grant
    Filed: February 13, 2016
    Date of Patent: February 4, 2020
    Assignee: The Regents of the University of California
    Inventors: Zhongping Chen, Jiang Zhu
  • Patent number: 10539682
    Abstract: The present invention relates to medical imaging, and in particular a medical imaging detector. In order to improve and facilitate the collection of information, e.g. for medical diagnosis, a medical imaging detector is provided that comprises a first sensor arrangement (12) and a second sensor arrangement (14). The first sensor arrangement is configured to provide a first type of image data belonging to a first imaging modality. The second sensor arrangement is configured to provide a second type of image data belonging to a second imaging modality. The first imaging modality is an X-ray imaging modality, while the second imaging modality is a non-X-ray imaging modality. The first sensor arrangement comprises one or a plurality of first sensor segments (16) arranged within a first circumferential line (18) defining a first imaging area (20).
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: January 21, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Johannes Wilhelmus Maria Jacobs, Walter Ruetten, Matthias Simon
  • Patent number: 10517689
    Abstract: Medical software tools platforms utilize a surgical display to provide access to specific medical software tools, such as medically-oriented applications or widgets, that can assist surgeons or surgical team in performing various procedures. In particular, an endoscopic camera may register the momentary rise in the optical signature reflected from a tissue surface and in turn transmit it to a medical image processing system which can also receive patient heart rate data and display relevant anomalies. Changes in various spectral components and the speed at which they change in relation to a source of stimulus (heartbeat, breathing, light source modulation, etc.) may indicate the arrival of blood, contrast agents or oxygen absorption. Combinations of these may indicate various states of differing disease or margins of tumors, and so forth. Also, changes in temperatures, physical dimensions, pressures, photoacoustic pressures and the rate of change may indicate tissue anomalies in comparison to historic values.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: December 31, 2019
    Inventor: Jack Wade
  • Patent number: 10507060
    Abstract: The present application describes computer apparatus and software programs useful to the field of corrective spinal surgery. The apparatus and software implement and facilitate methods for assessing the degree of balance and alignment achieved through corrective measures applied to the spine prior to completing a surgical procedure. The apparatus and software facilitate pre-operative planning and virtual testing of the corrective measures to be applied. The apparatus and software further facilitate intra-operative reconciliation with the pre-operative plan prior to completing the surgery.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: December 17, 2019
    Assignee: NuVasive, Inc.
    Inventors: Niall Casey, Jennifer Jassawalla, Eric Forman, Thomas Scholl
  • Patent number: 10507061
    Abstract: The present application describes computer apparatus and software programs useful to the field of corrective spinal surgery. The apparatus and software implement and facilitate methods for assessing the degree of balance and alignment achieved through corrective measures applied to the spine prior to completing a surgical procedure. The apparatus and software facilitate pre-operative planning and virtual testing of the corrective measures to be applied. The apparatus and software further facilitate intra-operative reconciliation with the pre-operative plan prior to completing the surgery.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: December 17, 2019
    Assignee: NuVasive, Inc.
    Inventors: Niall Casey, Jennifer Jassawalla, Eric Forman, Thomas Scholl
  • Patent number: 10507064
    Abstract: The present invention relates to a computer-implemented medical method of determining a spatial position of a medical optical observation device (1), the method comprising executing, on a processor of a computer (2), the steps of:—acquiring position data describing, for a plurality of points in time, the spatial position of the observation device (1) within a co-ordinate system of a medical tracking system (3);—determining, based on the position data, average position data describing an average value for the position of the observation device (1) within the co-ordinate system of the medical tracking system (2);—acquiring image data describing a plurality of images acquired at the plurality of points in time via a camera (4) assigned to the observation device (1) and detecting the field of view (5) of the observation device (1);—determining, based on the image data, optical flow data describing an optical flow for the plurality of images;—determining, based on the average position data and the optical flow dat
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: December 17, 2019
    Assignee: BRAINLAB AG
    Inventor: Sven Flossmann
  • Patent number: 10507065
    Abstract: Medical software tools platform utilizes a surgical display to provide access to specific medical software tools, such as medically-oriented applications or tools, that can assist those in the operating room, such as a surgeon or surgical team, with a surgery. In particular, an optical sensor located within an endoscopic camera may register subtle differences in color characteristics reflected from a tissue surface and in turn transmit the information to a medical image processing system. Moreover, the new tools are intended to help surgeons better determine the boundaries between healthy and diseased regions during surgical procedures. Various tools are intended to be used in procedures where indocyanine green (ICG) fluorescent dye is used. Intraoperative fluorescence imaging is commonly used during minimally invasive procedures to enable surgeons to visualize tissue perfusion and anatomical structures. The term perfusion refers to the passage of blood and tissue fluid through the capillary bed.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: December 17, 2019
    Inventor: Jack Wade
  • Patent number: 10507075
    Abstract: Medical software tools platforms utilize a surgical display to provide access to specific medical software tools, such as medically-oriented applications or widgets, that can assist surgeons or surgical team in performing various procedures. In particular, an endoscopic camera may register the momentary rise in the optical signature reflected from a tissue surface and in turn transmit it to a medical image processing system which can also receive patient heart rate data and display relevant anomalies. Changes in various spectral components and the speed at which they change in relation to a source of stimulus (heartbeat, breathing, light source modulation, etc.) may indicate the arrival of blood, contrast agents or oxygen absorption. Combinations of these may indicate various states of differing disease or margins of tumors, and so forth. Also, changes in temperatures, physical dimensions, pressures, photoacoustic pressures and the rate of change may indicate tissue anomalies in comparison to historic values.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: December 17, 2019
    Inventor: Jack Wade
  • Patent number: 10500010
    Abstract: Medical illumination systems and devices for illuminating a target surgical area with a pre-selected type of multispectral light to aid tissue differentiation as viewed by the human eye, especially in open-surgery settings, and methods for practicing the same. A light source may have multiple settings selectable to provide various types of multispectral light configured to reduce reflection from corresponding tissue types relative to full-spectrum light. A pre-selected type of multispectral light may be configured to reduce reflection from blood. An illumination system or device can have one more illumination elements, including combinations of LEDs, lasers, and filtered broadband light sources. The multispectral light may be or comprise one or more of a continuous or pulsed wave.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: December 10, 2019
    Assignee: Invuity, Inc.
    Inventors: Alex Vayser, Gaston Tudury, John Black
  • Patent number: 10492682
    Abstract: An ophthalmic analysis device for analyzing OCT motion contrast data including blood vessel information of a subject eye acquired by an ophthalmic OCT, includes: a processor; and memory storing computer readable program, when executed by the processor, causing the ophthalmic analysis device to execute: an analysis process of analyzing the OCT motion contrast data to acquire a measurement result related to a capillary area of the subject eye. The analysis process executes an alleviating process for alleviating the influence of great blood vessels having blood vessel diameters larger than those of capillaries on the measurement result to acquire the measurement result related to the capillary area.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: December 3, 2019
    Assignee: NIDEK CO., LTD.
    Inventors: Ryosuke Shiba, Norimasa Satake, Tetsuya Kano, Yasuhiro Furuuchi, Yuki Kuno, Ai Takaya, Naoki Takeno, Yukihiro Higuchi, Hajime Namiki