Abstract: A combined PET and X-Ray CT tomograph for acquiring CT and PET images sequentially in a single device, overcoming alignment problems due to internal organ movement, variations in scanner bed profile, and positioning of the patient for the scan. In order to achieve good signal-to-noise (SNR) for imaging any region of the body, an improvement to both the CT-based attenuation correction procedure and the uniformity of the noise structure in the PET emission scan is provided. The PET/CT scanner includes an X-ray CT and two arrays of PET detectors mounted on a single support within the same gantry, and rotate the support to acquire a full projection data set for both imaging modalities. The tomograph acquires functional and anatomical images which are accurately co-registered, without the use of external markers or internal landmarks.

Abstract: A nuclear medical imaging apparatus receives an associated object (18). A radiation detector (12) is equipped with a slat collimator (14) including a plurality of spaced apart slats (114) separating individual detecting elements of an essentially linear array of detecting elements (116). The slat collimator produces planar collimation and results in projection data which is weighted inversely with distance in the projection direction. An image reconstruction processor (34) converts the projection data obtained by the detector (12) into an image, including correction for the inverse distance weighting. The image reconstruction processor (34) includes a memory, a preconditioning operator P (36), a projection operator S (38), and an iterative loop operator (40) which applies the preconditioning operator P (36) and the projection operator S (38) to the memory contents to calculate updated memory contents.

Abstract: Apparatus and method for the precision aiming of a radiation beam for treating an internal cancer tumor in a patient. The method of treatment includes introducing at least one reference marker into the patient in a defined and locatable position in relation to the cancer tumor. A defined point in the cross section of the beam is located by a sight that is compared to the position of the reference marker and adjusted to ensure that the treatment beam is directed precisely at the cancer tumor before the remaining doses of radiation are given to the patient. The device according to the invention includes equipment for emitting a treatment beam, a sight arranged in the path of the beam to define a point in the cross section of the beam, and a device to read the beam arranged to receive the beam that has passed through the patient and visualize the position of the at least one said reference marker and the position of the sight.

Abstract: A Compton imager and method are provided for generating three-dimensional images. The Compton imager detects Compton scattering of simultaneously or nearly simultaneously emitted gamma rays produced by a radio-nuclide. A possible location of each radio-nuclide decay is defined by the intersection of Compton direction cones corresponding to the detected gamma rays. Three-dimensional images are generated by superposition of individual locations of separate radioactive decay locations.

Abstract: A probe or sheath for use on a probe for detecting and removing radioactively tagged tissue, e.g., a sentinel lymph node, within the body of a living being. The probe or sheath and probe is arranged to be inserted through a small percutaneous portal into the patient's body and is movable to various positions adjacent the tagged tissue to detect the presence of radiation therefrom so that it can be positioned immediately adjacent that tissue to ensnare or trap that tissue. The probe or sheath and probe can then be removed from the being's body, carrying the tagged tissue with it. The probe may be constructed to make use of a scintillation crystal, a collimator, adjustable or fixed, and a backshielding lightpipe. A blunt dissecting device is provided as part of the sheath or as part of the probe itself to aid in separating the tagged tissue from adjacent tissue without injury to the adjacent tissue. The probe may be a fully integrated, self-powered unit.

Abstract: According to one embodiment of the invention, a variable length correlation method is provided for compensating for body motions and heart creep in a sequence of image frames obtained by single-photon emission computed tomograph (SPECT) myocardial perfusion imaging. Abrupt body motions, gradual body motions, and heart upward creep are detected and corrected in the sequence of image frames, based on varying correlation lengths. A linear transformation is used to compensate for appearance changes of the heart under different acquisition angles so as to achieve high accuracy of motion detection and correction. The detecting and correcting step is applied in the two-dimensional image domain. The method also includes the steps of detecting and excluding high intensity, non-heart regions in a particular image frame so that non-heart motions such as bowel gas, spleen, and liver motions are excluded from being involved in the motion detection and correction procedure.

Abstract: Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments).

Abstract: An intraoperative probe system for preferentially detecting beta radiation over gamma radiation emitted from a radiopharmaceutical is described. In one embodiment, the probe system of the present invention is a probe having an ion-implanted silicon charged-particle detector for generating an electrical signal in response to received beta particles. In such an embodiment, a preamplifier may be located in close proximity to the detector filters and amplifies the electrical signal. Furthermore, a wire may be used to couple the probe to a processing unit for amplifying and filtering the electrical signal, and a counter may be utilized to analyze the resulting electrical signal to determine the number of beta particles being received by the detector. Alternatively, the wire can be replaced with an infrared or radio transmitter and receiver for wireless operation of the probe.

Abstract: The present invention describes an apparatus for an improved patient support table for use in nuclear medical studies. The table provides regions, such as a slot or hole, where there is lowered radiation attenuation for particular regions of the body. By supporting and aligning the patient with these regions of lowered radiation attenuation, better image quality and/or lowered radiation dosage may be achieved.

Abstract: A small-size gamma camera is capable of reliably and quickly detecting the accumulated position of a radiation source in an examinee. When the examinee is scanned with the gamma camera which has an area sensor comprising 256 (16×16) semiconductor detecting elements, display elements of a display unit on a rear panel of the gamma camera are turned on to display a pattern indicative of the accumulated position of the radiation source. According to the displayed pattern on the display elements, the operator of the gamma camera moves the gamma camera to detect the accumulated position of the radiation source reliably within a short period of time.

Abstract: A stereo radiolocalization and targeting system (100) includes a table assembly (102) for supporting a patient (104), a stereo radiolocalization subsystem (117), a medical instrument support subsystem (119), and an ultrasound imaging subsystem (121). The stereo radiolocalization subsystem (117) provides three-dimensional localization information for an area of interest within the patient's body such as a sentinel node. The medical instrument support subsystem (119) allows for targeting of a medical instrument (118) to the area of interest for treatment, extraction or other procedures. The imaging subsystem (121) provides real-time imaging for use in penetration path selection and monitoring medical instrument insertion. Flexible positioning support mechanisms (120, 122, and 124) provide substantial positioning flexibility for various elements of the system (100).

Abstract: A method is provided for immune corrective surgical removal of lymphoid tissues containing shed tumor antigen in an individual. A detector molecule, with binding specificity for shed tumor antigen, is administered to an individual, and detected in the individual is the presence of lymphoid tissue which contains shed tumor antigen, as detected by the signal emitted by the detector molecule bound to shed tumor antigen. The lymphoid tissue, detected as containing shed tumor antigen, may then be surgically removed, thereby removing B cells, shed tumor antigen, and follicular dendritic cells involved in a pro-tumor immune response that are contained in the removed lymphoid tissue.

Abstract: A method of removing lesions by implanting a radioactive seed at the location of the lesion, locating the lesion with the radioactive seed, and removing the lesion with the radioactive seed.

Abstract: The present invention relates generally to in vivo evaluation of labeled lesions within a body lumen using a catheter having an array of radiation detectors. The present invention provides catheters and methods which detect radiotracers which have bound to vulnerable plaque. The radiation detectors can be coupled to a signal processor through a delay line so as to reduce the number of transmission lines traveling through the catheter to the outside of the body. The radiation detectors can be semiconductor detectors or optical detectors.

Abstract: One aspect of the present invention relates to screening patients for an early stage of coronary artery disease. According to this method, a patient is screened based on the time-activity curve for a radioactive tracer passing through a left ventricle region of the patient's body. According to another aspect of the invention, an array of gamma particle detectors is employed to obtain data for a region of interest that is larger than and encompasses a left ventricle region of the patient's body. An analysis of the data identifies the subset of the region of interest that corresponds to the left ventricle region. According to a further aspect of the present invention, a second technique is employed to locate the left ventricle region. A still further aspect of the present invention relates to obtaining images of a patient's heart using a high temporal resolution gamma camera.

Abstract: A technique is provided for evaluation of an operative state of a medical diagnostic system. The technique is particularly adapted to evaluating image data from a variety of imaging modalities, including magnetic resonance imaging systems, computed tomography imaging systems, x-ray imaging systems, and so forth. A user interface permits a service request to be formulated at the diagnostic system. Data files, such as image files, log files, error files, and so forth, are identified and stored corresponding to the service request. The service request is then transmitted to a remote service facility for evaluation. The necessary data files may be transmitted with the request or subsequent thereto. The request is acknowledged by the remote service facility in an electronic message. The request uniquely identifies the diagnostic system, as well as the modality of the system.

Abstract: A system calibrates a user's brain region (e.g., the primary visual cortex or V1 region) to actual sensory information (e.g., the visual field), and enables imagined sensory information (e.g.; dynamic mental imagery) to be interpreted as computer input. The system includes a configuration engine and an input device control engine. The configuration engine includes a test pattern; a functional information gatherer for presenting the test pattern to a user; a brain-scanning device interface for obtaining functional information from a region in the user's brain that provides a physiological response to the test pattern and that receives feedback corresponding to imagined sensory information; and a mapping engine for using the functional information to map the user's brain region to the test pattern.

Abstract: An automatic calibration method is provided for calibrating a radiation detection system for processing counts from a known radiation source. A probe is positioned near the radiation source, which may be the surgical injection site of a radionucleide. A control unit generates audible and/or visual feedback signals to cue the operator as to where to position the probe relative to the radiation source, in order to obtain a pulse frequency (count rate) in an optimal range for processing. The control unit then automatically identifies a probe output corresponding to a peak energy level and calibrates the system to that peak. Once calibrated, the system may set an energy acceptance window having a mathematical relationship to the peak energy level, whereby the radiation detection system thereinafter processes only counts corresponding to energy levels falling within the energy acceptance window.

Abstract: These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.

Abstract: A method of determining the viability of a hibernating or stunned myocardial segment comprises the administration of ribose, a vasodilator and an inotropic agent. The preferred agent is dobutamine, which has both a vasodilation and an inotropic effect. The segments may be identified by myocardial imaging by any known means, such as echocardiography, Thallium-201 tracing or positron emission tomography. Ribose is preferably given one minute to three hours prior to administration of the vasodilator and inotropic agents.

Abstract: A method for determining a time for acquiring contrast-enhanced images from a CT scanner of a subject into whom a contrast medium has been injected, the method including: identifying a region of interest in an initial CT image of the body of a subject; defining an attenuation data segment corresponding to the region of interest by reprojecting the region of interest in the initial image; receiving attenuation data within the segment from a subsequent scan of the patient; and independently processing the attenuation data received within the segment to estimate an optimal time for performing a diagnostic scan of the body, without reconstructing all or a portion of the CT image.

Abstract: A tomographic imaging system includes a moveable detector or detectors capable of detecting gamma radiation; one or more position sensors for determining the position and angulation of the detector(s) in relation to a gamma ray emitting source; and a computational device for integrating the position and angulation of the detector(s) with information as to the energy and distribution of gamma rays detected by the detector and deriving a three dimensional representation of the source based on the integration. A method of imaging a radiation emitting lesion located in a volume of interest also is disclosed.

Abstract: A multidiagnostic rectilinear scanner for conducting non-invasive diagnostic procedures of bodily tissue. Both transmission and emission studies are performed on a single scanner utilizing software modules for each kind of study. Dual energy x-ray and radioactive sources are used to perform radiographic and absorptiometry transmission measurements. A system and method of identifying regions of interest within tissue being scanned and recording the location of those regions provides an additional diagnostic capability.

Abstract: A technique for localizing an internal bleeding site in the human body is provided. The technique entails the injection of radioactively labelled protein or factor used in the clotting process in solution into a human body When the protein or factor has built up in sufficient quantities at a bleeding site to form a clot, the radioactive emission is used to detect the location of the clot. One or more passes of the detector can be used to accurately pinpoint the location of the clot, and thereby, locate the bleeding site.

Abstract: In a dosimeter probe comprising a semiconductor diode or a field effect transistor for monitoring levels of radiation during medical procedures, such as the treatment of tumors, the transistor or diode is fabricated epitaxially upon a surface of a substrate and a dummy die, i.e., a slab of material similar to that of the substrate, is positioned adjacent the substrate surface so as to overlie an active region of the transistor or diode and a relatively large area of the substrate surrounding the active region. The arrangement is such that, whatever the direction from which the radiation is incident upon the active region, its path through the device before arriving at the active region will have similar characteristics to the path the radiation takes upon leaving the active region.

Abstract: There is provided a radiation detection apparatus having a hand-held radiation detection probe with a switch assembly removably mounted thereon. The switch assembly having first and second switches, one to initiate transmission of electrical signals representing scintillations detected over a set time period to a remotely located control unit for counting and averaging, and the other to direct the control unit to download and preferably record the counted and averaged scintillation values for further use. The switch assembly has an insulating member for electrically insulating the switches from the probe, and spaced gripping members that releasably grip the probe. A movable stand is provided preferably with a holder for holding the probe. The probe can have a protective cover thereon with a switch assembly mounted onto the probe over the cover.

Abstract: A scanning system for a hand-held probe employs a 50 ms scanning interval in conjunction with circular memory. Combinations of segment bins from the circular memory are acquired following each short scanning interval. A threshold is computed for each combination initially based upon a threshold factor which is statistically significant and has a value of three. Audible cueing is developed if any three of six of these combinations of segment bin scan counts exceeds a correspondingly computed threshold value. Thereafter, the threshold factor is diminished to a value of one and the same thresholding tests are carried out to maintain audible cueing. Running count rates are computed as the average of the entire circular buffer memory divided by its corresponding total collection time. This computation is provided on a one half second updated basis.

Abstract: Disclosed herein are methods for locating hyperactive parathyroid tissue in a patient. The methods comprise providing a radiopharmaceutical which produces during a time window after administration of the radiopharmaceutical to the patient, a detectably greater radioactivity in the hyperactive parathyroid tissue than in adjacent thyroid tissue in the patient; administering the radiopharmaceutical to the patient; surgically opening an operative field in the proximity of the hyperactive parathyroid tissue; and introducing into the operative field during the time window, a probe, which detects the radioactivity produced by the hyperactive parathyroid tissue to determine the location of the hyperactive parathyroid tissue upon moving the probe within the operative field. The method is particularly applicable to radioguided parathyroidectomy using a 99mTc Sestamibi and a hand-held gamma detection probe. The gamma detection probe is also used to verify ex vivo that the resected tissue is parathyroid adenoma.

Abstract: A radiation detection apparatus includes a hand-held probe with a switch assembly removably mounted thereon. The switch assembly having first and second switches, one to initiate transmission of electrical signals representing scintillations detected over a set time period to a remotely located control unit for counting and averaging, and the other to direct the control unit to download and preferably record the counted and averaged scintillation values for further use. The switch assembly has an insulating member for electrically insulating the switches from the probe, and spaced gripping members that releasably grip the probe. A movable stand is provided preferably with a holder for holding the probe. The probe can have a protective cover thereon with a switch assembly mounted onto the probe over the cover.

Abstract: A method and apparatus for simultaneously acquiring imaging data at two different resolutions, a high resolution data set using for forming a diagnostic image and a plurality of low resolution data sets used for various purposes including high resolution data correction for patient movement and data errors and for observing dynamic physiological occurrences.

Abstract: A modular radiation detecting probe system includes a probe body having a handle portion and a distal portion to which an extension member is attached. The free end of the extension member is adapted to matingly attach and detach, one at a time, with various probe tips. An electronic signal acquisition system is disposed within the probe body and is coupled to receive a signal output from an attached probe tip. The acquisition system signal process the signal to discriminate between noise and a radiation signal detected by the probe tip. The probe body may include visual and/or audible devices to signal when the probe tip is adjacent a radiated area. The probe body may include a transmitted to transmit acquired signal data to an external signal processing unit, which may be a computer.

Abstract: Apparatus and method are provided for constructing image slices through a selected object undergoing a cyclic motion wherein a scanner is used for collecting image data associated with the selected object. A probe is provided for detecting a signal from the selected object, the signal being indicative of the cyclic motion of the object. The scanner and the probe are operatively connected with a controller. The controller receives the signal from the probe and generates therefrom a command for enabling the scanner to collect image data for producing one or more image slices through the selected object with minimized radiation exposure and data acquisition time.

Abstract: The present invention is an apparatus for examining a body part. The apparatus comprises a mechanism for immobilizing and compressing the body part. The apparatus also comprises a mechanism for providing an internal anatomical image of the body part and a mechanism for detecting single gamma-rays emitted by a radiotracer infiltrated into the body part. The detecting mechanism is disposed in an adjacent relationship with the mechanism for providing an internal anatomic image so that the body part remains in the same position during and between anatomic and radiotracer imaging. In one embodiment, the detecting mechanism includes a detector module disposed on one side of the immobilizing mechanism. The detector module preferably has at least one array of gamma ray sensitive material in communication with a position detector. In another embodiment, the detecting mechanism includes a pair of detector modules disposed one on each side of the immobilizing mechanism.

Abstract: The radiology instrument contains a source emitting X-radiation, a radiological image receiver, a chassis arranged between the X-ray source and the image receiver in order to accommodate an object to be radiographed, and a positioning and guiding device which can be connected to the chassis and can intercept the X-radiation so as to position and guide probes intended to interact with the object. The positioning and guiding device has first means forming a retractable guide grid having holes whose respective axes converge towards the focal point of the source when the first means intercept the conical radiation, and a retractable positioning grid with holes.

Abstract: A system having a plurality of light sources that emit light focused to treat an internal treatment site at a location determined using an imaging device that is integrally mounted in a housing with the plurality of light sources. The imaging device may include, for example, either an ultrasonic transducer or a gamma probe that produces a signal suitable for displaying an image of the internal treatment site. The image thus displayed enables the location, shape, extent, and depth of the internal treatment site to be determined so that an operator can correctly position the housing in which the imaging device and light sources are disposed. Each light source is provided with either a conventional refractive lens or a totally internally reflective (TIR) lens that directs and focuses the light at the appropriate depth within a patient's body.

Abstract: A system for describing the physical distribution of an agent that accumulates selectively in tissue of a patient in an excised surgical specimen. The system comprises an agent which selectively concentrates in a cancer or precancer or focus of infection or other pathological condition. The system comprises a detector sensitive to the agent which is present in the surgical specimen. The system also comprises an apparatus capable of forming an image based on the information gathered by the detector, and which image describes the physical distribution of the agent in the surgical specimen so that a surgeon can be guided by the image provided by the apparatus, said apparatus connected to said detector.

Abstract: There is disclosed a method of positioning an interventional device in a body using a guide pivoting about a pivot point, performed by locating the spatial coordinates of a target and the pivot point, determining a third point outside of the body lying along or proximate a line extending through the target and pivot point, and aligning the axis of the guide with the third point using an imaging system. There is also disclosed a medical imaging system including a processing unit and computer software operative on the processing unit to permit an operator of the system to locate the spatial coordinates of a target point and a pivot point of a guide, and determine a third point outside of the body lying along or proximate a line extending through the target and pivot point. This medical imaging system may further include computer software operative on the processing unit to assist an operator in obtaining an image by which the axis of the guide can be aligned with the third point using an imaging system.

Abstract: Methods and computer executable instructions are disclosed for ultimately developing a dosimetry plan for a treatment volume targeted for irradiation during cancer therapy. The dosimetry plan is available in “real-time” which especially enhances clinical use for in vivo applications. The real-time is achieved because of the novel geometric model constructed for the planned treatment volume which, in turn, allows for rapid calculations to be performed for simulated movements of particles along particle tracks there through. The particles are exemplary representations of neutrons emanating from a neutron source during BNCT. In a preferred embodiment, a medical image having a plurality of pixels of information representative of a treatment volume is obtained. The pixels are: (i) converted into a plurality of substantially uniform volume elements having substantially the same shape and volume of the pixels; and (ii) arranged into a geometric model of the treatment volume.

Abstract: An apparatus and method for marking the location for excising a bone lesion by surgery. A localizing needle containing radioactive source of radiation at its tip, is received in a guide needle, with sharp ends of both needles juxtaposed. A cable extends from the opposite end of the localizing needle through the guide needle lumen and out the proximal end of the guide needle. With the bone lesion visualized on a monitor in real time, the needle combination is inserted, tip-first, through the skin and advanced toward the lesion. The radiation from the localizing needle tip assists the surgeon to manipulate the guide needle tip to a marker site on the bone immediately adjacent the lesion. The guide needle tip is pushed into and securely held in the bone. In one embodiment, a handle secured to the cable outside the proximal end of the guide needle is rotated a quarter turn to anchor hooked tips of the localizing needle in the bone.

Abstract: Process for producing benefit/risk evaluation data relating to radiation therapy in patients comprising the following stages: production of imaga data on the spatial positional distribution of relevant organ and tissue parts; production or selection of radiation data; production of radiation dose distribution data; storage of a plurality first rules; fetching of suitable first rules; storage of a plurality of second rules; fetching and application of suitable second rules; production of benefit/risk evaluation data based on the total radiation effect data produced; and fetching of suitable radiation data.

Abstract: A method and apparatus for detecting beta particles in the presence of high gamma background using secondary electron emission (SEE) as the primary beta particle detector. Diamond-like thin films having coefficients for SEE as high as 50 are preferably used in a small hand-held probe whereby radiolabeled malignancies as small as 3 mm in diameter can be detected. An electron multiplier amplifies the secondary electron signal for generation of an audible signal or a display indicative of the level of beta radiation passing through the air-vacuum interface of the hand-held probe.

Abstract: Count rate outputs of a probe-based radiation detection system are stabilized through the utilization of a dynamic window-based count analysis. Circular memory is utilized to record a sequence of segment count values. These values then are accessed and updated with respect to short scan intervals. The memory segments then are employed to develop a count sum over a count collection interval. That count sum is employed with algorithms adjusting the upper and lower edges of the dynamic window. A reported mean value, computed from the window upper edge or window lower edge, is utilized for creating a variable pitch output or for driving a bar graph. Background count and target count intervals are adjusted utilizing a data point predictive technique in combination with upper and lower time bounds.

Abstract: A system and method for diagnostic testing of structures within a body, e.g., organs within the body of a living being, which has been provided with a radioactive imaging agent, e.g., a radiotracer, to cause the structure to produce gamma rays, associated characteristic x rays, and a continuum of Compton-scattered photons. The system includes a radiation receiving device, e.g., a hand-held probe or camera, an associated signal processor, and an analyzer. The radiation receiving device is arranged to be located adjacent the body and the structure for receiving gamma rays and characteristic x rays emitted from the structure and for providing a processed electrical signal representative thereof. The processed electrical signal includes a first portion representing the characteristic x rays received and a second portion representing the gamma rays received.

Abstract: A system and a method for evaluation of gastrointestinal function is presented. The system consists of a catheter, a recorder and software. The catheter includes one or more CdTe sensors for measuring isotope activity. The catheter CdTe sensors are placed in the gastrointestinal tract to measure gastric emptying or gastrointestinal output after administration of radiolabeled liquid or solid meals. Data is stored in the recorder or displayed on-line on a computer screen. Other parameters such as pH can be added for a more complete evaluation of gastrointestinal function. The computer software is written for the Windows environment. The software includes provisions for general ambulatory and stationary data acquisition. The software also includes realtime analysis combined with an extensive patient journal where all items are described as objects in understandable userfriendly language connected to a database.

Abstract: An intraoperative probe system for preferentially detecting beta radiation over gamma radiation emitted from a radiopharmaceutical is described. In one embodiment, the probe system of the present invention is a probe having an ion-implanted silicon charged-particle detector for generating an electrical signal in response to received beta particles. In such an embodiment, a preamplifier may be located in close proximity to the detector filters and amplifies the electrical signal. Furthermore, a wire may be used to couple the probe to a processing unit for amplifying and filtering the electrical signal, and a counter may be utilized to analyze the resulting electrical signal to determine the number of beta particles being received by the detector. Alternatively, the wire can be replaced with an infrared or radio transmitter and receiver for wireless operation of the probe.

Abstract: The surgical probe according to the invention includes a collimator, made of lead or a high Z, atomic number metal; a scintillating crystal sensitive to gamma ray having an energy in the range from 30 KeV and 1 MeV; a light guide system; a photomultiplier; and electronics capable of integrating and converting analog signals to digital signals. The probe can be used in either intracavitary mode, or in laparoscopic mode, by putting the probe in a specific trocar. The apparatus may automatically subtract the background; and may provide visualization on a monitor. The probe can also include a flexible tip, in order to enlarge the field of view which the probe can be used to examine.

Abstract: A system for use in Boron Neutron Capture Therapy (BNCT) radiotherapy planning where a biological distribution is calculated using a combination of conversion factors and a previously calculated physical distribution. Conversion factors are presented in a graphical spreadsheet so that a planner can easily view and modify the conversion factors. For radiotherapy in multi-component modalities, such as Fast-Neutron and BNCT, it is necessary to combine each conversion factor component to form an effective dose which is used in radiotherapy planning and evaluation. The Dose Factor Entry and Display System is designed to facilitate planner entry of appropriate conversion factors in a straightforward manner for each component. The effective isodose is then immediately computed and displayed over the appropriate background (e.g. digitized image).

Abstract: A surgical probe wherein a heat sterilizable and reusable detector component is combined with a disposable handle and cable assembly. The reusable detector component incorporates a detector crystal and associated mountings along with preamplifier components. It is formed having a positioning shaft extending therefrom to a contact supporting surface carrying a pattern of electrical contact surfaces. The disposable handle employs an insert member having a receiving cavity. The electrical contact carrying tip of the shaft moves into electrical engagement with a pattern of electrical contacts mounted within the handle in conjunction with a permanently affixed flexible cable.

Abstract: A system and apparatus for obtaining medical quality images of a body under stress, such as a body in motion, are disclosed. The apparatus preferably consists of a harness into which the imaging device may be removably placed and securely positioned with respect to a body part, even when the body is in motion. The system preferably further comprises a small, light weight gamma camera. The imaging device is preferably supported by a mechanism which is separate from the harness. In each embodiment of the invention, movement of the imaging device relative to the body is minimized, yet the body is permitted to move relatively freely. Methods for use of the apparatus and system to obtain medical images of a body are also described.

Abstract: A medical method and apparatus for the localization and biospy of lesions in a patient body part. A radiopharmaceutical is administered to the patient followed by placement of the body part within a scanner for obtaining emission data. The emission data is converted into Cartesian coordinates which are used to guide a sampling instrument for the biopsy of said lesion.