Abstract: Systems, processes, and apparatuses are provided for imaging a body part of a patient such as an eye of the patient. In some embodiments, a process is provided for adjusting the readings from an ultrasound probe to account for the different speeds of sound through different portions of the eye. In various embodiments, a process is provided for combing multiple images of the body part together. In some embodiments, a process is provided for determining the diameter of the lens of the eye.

Abstract: Methods for treating skin and subcutaneous tissue with energy such as ultrasound energy are disclosed. In various embodiments, ultrasound energy is applied at a region of interest to affect tissue by cutting, ablating, micro-ablating, coagulating, or otherwise affecting the subcutaneous tissue to conduct numerous procedures that are traditionally done invasively in a non-invasive manner. Methods of lifting sagging tissue are described.

Abstract: An interventional instrument (30) having ultrasound sensors (S1, S2, S3, S4, . . . ) is tracked using an ultrasound imaging device (10) that acquires and displays a 2D ultrasound image of a visualization plane (18), and performs 2D ultrasound sweeps for a range of plane angles (?) obtained by rotating the ultrasound probe (12) and encompassing the visualization plane angle. For each ultrasound sensor, an optimal plane is found based on its emitted signal strength over the range of plane angles, and the ultrasound sensor is located in its optimal plane by analyzing the sensor signal as a function of the timing of the beams fired by the ultrasound probe. These locations in their respective optimal planes are transformed to a 3D reference space using a transform (42) parameterized by plane angle, and a visual indicator is displayed of spatial information (T, L) for the interventional instrument generated from the locations of the one or more ultrasound sensors in the 3D reference space.

Abstract: An ultrasound probe (“probe”) for use with an ultrasound imaging system is disclosed. In particular, the probe is sized and configured so as to be supported and readily used with as little as one finger on a single hand of a user of the imaging system. This configuration enables remaining fingers on the hand of the user to be employed for other purposes, such as skin traction and patient contact. In one embodiment, therefore, an ultrasound probe is disclosed, comprising a body, a lens included on head portion of the body, a stabilizing portion extending from the body and configured to stabilize the body on a skin surface of a patient without user assistance, and a finger grip portion configured to enable a user of the probe to grasp and maneuver the probe during use thereof with no more than two fingers on a single hand of the user.

Abstract: A system may obtain orthogonal pairs of acoustic waveforms obtained by a rotating downhole acoustic tool. The downhole tool may include an acoustic transmitter and an acoustic receiver. A computing device communicatively coupled to the downhole tool that instructs the transmitter to generate the various waveforms detected by the acoustic receiver and store the various waveforms in a buffer. Each waveform of a subset of the various waveforms oriented in a similar direction may be stacked to generate a composite waveform with reduced noise. The computing system may determine an orthogonal pair of waveforms based on the composite waveform and remaining waveforms.

Abstract: A method for estimating a physical condition used by a computer includes simultaneously measuring blood flow volumes of at least two body parts of a person and estimating the person's physical condition on the basis of the blood flow volumes of the at least two body parts measured in the simultaneously measuring.

Abstract: Embodiments herein disclose a method and system for cuff-less blood pressure (BP) measurement of a subject. The method includes measuring, by one or more sensors, a local pulse wave velocity (PWV) and/or blood pulse waveforms of an arterial wall of the subject. Further, the method includes measuring, by an ultrasound transducer, a change in arterial dimensions over a cardiac cycle of the arterial wall of the subject. The arterial dimensions include an arterial distension and an end-diastolic diameter. Furthermore, the method includes measuring, by a controller unit, BP of the subject based on the local PWV and the change in arterial dimensions.

Abstract: A wearable vital sign monitor. The wearable vital sign monitor includes a band, where the band secures the wearable vital sign monitor relative to a user. The band includes an interior surface, the interior surface being the surface closest to the skin of the user and an exterior surface, the exterior surface opposite the interior surface. The wearable vital sign monitor also includes a first sensor array. The first sensor array is attached to the band and includes at least two sensors. The wearable vital sign monitor further includes a second sensor array. The second sensor array is attached to the band a fixed distance from the first sensor array and includes at least two sensors. The wearable vital sign monitor additionally includes an electronics module. The electronics module is configured to receive a first signal from the first sensor array, receive a second signal from the second sensor array, and transmit the sensor data to an external device.

Abstract: A direct visualization (DV) system and methods are disclosed for measuring one or more anatomical features of the eye, including a depth of the iridocorneal angle of the eye. The DV system can include a wire extending distally from a handle with the wire having one or more indicators for measuring anatomical features of the eye. The DV system can be deployed into the eye and used with minimal trauma to ocular tissues. Furthermore, the DV system can be used independently or alongside other ocular instruments, such as instruments having indicators corresponding to the DV system for correctly implanting ocular implants without the use of a gonio lens.

Abstract: Systems, methods, and devices of the various embodiments enable continuous non-invasive monitoring of blood pressure with a minimum of interference. The various embodiments may provide a method for adaptation for the calibration for continuous measurements of blood pressure, wherein the measured quantity may be related to an arterial lumen or arterial cross sectional area comprising calibrating the conversion for incremental variations of arterial properties and absolute value adaptation by exploitation of the exponential decay during the diastole. In various embodiments, continuous calibration of a non-interfering blood pressure measurement device may be initiated based on a change in mean arterial pressure being greater than a threshold value, such as a pressure value associated with an actual measured distension of a patient's artery.

Abstract: A delivery system for a medical implant and a method of delivering the medical implant. The delivery system includes an inner catheter and an outer catheter. The inner catheter includes a wire coil disposed between an inner tube and an outer tube, the wire coil having gaps between turns of the coil at a proximal and a distal region thereof. The outer catheter is disposed about the inner catheter. The system includes a flow path for liquid from a proximal end to a distal end thereof, the flow path including a radially extending portion through the gaps. The method includes inserting the delivery system into a body lumen, injecting visualizing fluid into the proximal end of the system, the visualizing fluid moving through the flow path and exiting the distal end of the system, and retracting the outer catheter to release the medical implant.

Abstract: A method and device for multi-directional selective plane illumination microscopy is provided. A detector focal plane is alternately illuminated with at least two counter-propagating, coplanar light sheets, and an image of a specimen cross-section positioned in the focal plane is detected while only one light sheet illuminates the specimen. The wavefront of the illumination beams may be deformed with adaptive optics using feedback from light transmitted through the specimen. Multiple images of the specimen cross-section may be detected at different times and specimen positions and orientations to produce multi-view image stacks which may be processed using image fusion to produce a reconstructed image representation of the specimen. Additionally, the direction of propagation of the alternating light sheets may be pivoted in the focal plane while detecting the image.

Abstract: Systems and methods of analyzing an optical coherence tomography image of a retina are discussed. A 2-dimensional slice of the image can be aligned to produce an approximately horizontal image of the retina and an edge map based at least in part on the aligned slice. Also, at least one global representation can be determined based on a (multi-scale) spatial division, such as multi-scale spatial pyramid, on the slice and/or edge map. Creating the local features is based on the specified cell structure of the global representation. The local features can be constructed based on local binary pattern (LBP)-based features. Additionally, a slice can be categorized into one or more categories via one or more classifiers (e.g., support vector machines). Each category can be associated with at least one ocular pathology, and classifying can be based on the constructed global descriptors, which can include the LBP-based local descriptors.

Abstract: Methods and systems are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Some embodiments described apparatus and methods useful in photoablation of tissues. In some embodiments, a photoablation apparatus is used to perforate a tissue, forming an aperture into a space behind the tissue. Gases formed during a photoablation process can be used to pressurize the space behind the tissue to enhance patency of the space. In some embodiments the tissue is the trabecular meshwork of the eye and a wall of Schlemm's canal, and the space behind the tissue is a portion of the lumen of Schlemm's canal. In some embodiments, the method is useful in the treatment of glaucoma by improving outflow from the anterior chamber of the eye into Schlemm's canal, reducing intraocular pressure.

Abstract: A method of evaluating dry eye in humans wherein the flow of naturally occurring secretion to the eye is reduced or stopped due to the presence of an obstruction of a meibomian gland in the eyelid involves applying a pressure to the eyelid that mimics pressure applied during blinking; and simultaneously imaging the glands to diagnose the condition of the meibomian gland. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Abstract: A device and method are disclosed for detecting and correcting unintended eye movements that may occur during an ultrasound scan by monitoring multiple position tracking sensors, examples being but not limited to ultrasound or optical position sensors. These position tracking sensors are in addition to the ultrasound imaging transducer and are in a fixed position on the scan head so as not to move during the scanning operation. These position tracking sensors can continuously monitor the distance to the cornea or other clearly defined anatomical features of the eye such as the posterior pigment layer of the iris during the movement of the scan head assembly and can provide continuous multi-dimensional correction for any unwanted motion of the eye relative to the scan head that may occur during the ultrasound scan.

Abstract: Embodiments of the present invention are directed to methods of rapidly obtaining ultrasonic images of the eye using a set of procedural options that can be automated by a positioning mechanism that can be controlled by software.

Abstract: A method and apparatus are disclosed for generating accurate and precise ultrasonic images of biological materials or animate objects, such as the cornea and lens of the eye, and, in particular, to an ultrasonic scanning apparatus that can position its virtual center of curvature such that its ultrasonic transducer will emit pulses that reflect substantially perpendicularly from a curved specular surface of interest within the eye. This invention can allow real time imaging of a lens as it accommodates and can better enable researchers and ophthalmic surgeons to develop, fit, implant and diagnose performance of artificial lenses including accommodative lenses.

Abstract: Devices, systems and methods for ocular ultrasound are provided having therapeutic and/or diagnostic applications. In one aspect, an ocular probe is disclosed that is uniquely configured for use in the eye on the basis of shape and frequency. The ocular probe may be multi-functional, providing sensor, optical or other functionality in additional to ultrasound energy.

Abstract: In depth-resolved imaging of scattering media, incident light interacts with tissue in a complex way before the signal reaches the detector: Light interacts with media between the light source and a specific depth, then scatters at that depth and the backscattered light again interacts with media on its way to the detector. The resulting depth-resolved signal therefore likely does not directly represent a physical or optical property of the media at those depths. Exemplary systems, methods and computer-accessible medium can determine physical or optical properties based on such depth-resolved signals. For example, almost all the light can interact with the media, and that the energy of the incident light at a certain depth is likely therefore related to the integral of the scattered light from all deeper locations. Based on the detected signals, the properties of the media can be estimated in an iterative way.

Abstract: A method of evaluating dry eye in humans wherein the flow of naturally occurring secretion to the eye is reduced or stopped due to the presence of an obstruction of a meibomian gland in the eyelid involves applying a pressure to the eyelid that mimics pressure applied during blinking; and simultaneously imaging the glands to diagnose the condition of the meibomian gland. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Abstract: The invention relates to a method and furthermore a device from the examination of cavities, in particular an eye, by means of laser scanning. The aim of the invention is to carry out further investigations, above all with respect to possible diseases. Said aim is achieved, whereby the determination of the cavity wall thickness, in particular of retinal cavities is carried out. The external diameter and the internal diameter are determined by scanning doppler laser and the wall thickness determined from the data recorded thus.

Abstract: Backing substrates for reducing parasitic echoes produced within a ultrasonic transducer are provided comprising a polymeric material, for example, an epoxy having a glass transition temperature (Tg) ranging from about 10 to 50° C.; or an epoxy having an acoustical attenuation that increases by at least about 2 dB/mm at 5 MHz in a temperature range of about 5° C. to 40° C. Transducer assemblies comprising the backing substrates and methods for producing the assemblies are also provided.

Abstract: An ophthalmological measuring system for obtaining biometric data of an eye with a view to the pre-operative determination of a replacement lens or supplementary lens or refractive operations. The invention includes a combination of a measuring instrument based on ultrasound, an optical measuring instrument, and an evaluation unit, measuring values of the optical measuring instrument and/or of the measuring instrument based on ultrasound being used by the evaluation unit for determining the biometric data of an eye. Furthermore, keratometric and/or pachymetric measurements can also be carried out. The combination of different measuring systems enables a complete examination or diagnosis of a patient on a measuring table, so that the patient does not need to be moved, or have to come back at a later date for more measurements.

Abstract: A device (10) used with high frequency ultrasound provides a replaceable barrier between the ultrasound transducer and the tissues being imaged. The device (10) provides an acoustic pathway of minimal effect on the ultrasound signals, and furthermore provides for a safety barrier between a mechanical scanner and the tissues being imaged. The configuration of the device (10) allows it to function as a standoff for the ultrasound transducer to place the focus of the ultrasound beam at the desired depth of tissue for imaging. In addition, the device (10) may be sterilized and replaced as needed, providing sterile tissue contact surfaces. The device (10) has additional features, which are especially advantageous for diagnosis and surgery of the eye.

Abstract: Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.

Abstract: An ophthalmological measuring system for obtaining biometric data of an eye. with a view to the pre-operative determination of a replacement lens or supplementary lens or refractive operations. The invention includes a combination of a measuring instrument based on ultrasound, an optical measuring instrument, and an evaluation unit, measuring values of the optical measuring instrument and/or of the measuring instrument based on ultrasound being used by the evaluation unit for determining the biometric data of an eye. Furthermore, keratometric and/or pachymetric measurements can also be carried out. The combination of different measuring systems enables a complete examination or diagnosis of a patient on a measuring table, so that the patient does not need to be moved, or have to come back at a later date for more measurements.

Abstract: Disclosed is a method and apparatus for generating a two dimensional (2D) image of a structure (e.g., an organ) that has at least one pixel corresponding to at least one voxel of a three dimensional (3D) image of the structure. First, the surface of the structure in the 3D image is modeled by a geometrical volume such as an ellipsoid. Next, normal maximum intensity projection (MIP) rays are cast (i.e., projected) for voxels of the geometrical volume. The 2D image is then generated using the rays. The 2D image has at least one pixel that corresponds to at least one voxel of the 3D image.

Abstract: Unipolar, bipolar or sinusoidal transmitters may leave the transmitter in any of various states at the end of one pulse. Undesired acoustic energy may be generated to change states prior to beginning another transmit sequence or pulse. For example, phase inversion for tissue harmonic imaging is performed where two sequential pulses are transmitted with different phases. The first waveform starts at a low state and ends at the low state of a unipolar transmitter. The next waveform starts at the high state. Transmit apodization or spectrum control techniques may require a pattern of waveform starting states different than a current state. Acoustic disruption due to a change of state of the transmitter between transmissions for imaging is minimized.

Abstract: Laser guided fixation system and method for assuring alignment, constant pressure, and stationary positioning during ultrasound measurement of the eye: The invention employs a stable multi-purpose platform that carries a prior art ultrasonic probe used to measure the axial length of the eye, a projected laser spot as a fixation device, a gravity dependent swing arm with dual levels to maintain constant orientation and adequate pressure on the eye during measurement and a headpiece which keeps the entire apparatus stationary in relation to the patient's head. The method for using the invention describes a protocol which results in accurate and reproducible axial length measurements by establishing a means for assuring proper orientation, controlled pressure, and stationary positioning during axial length measurement of the eye.

Abstract: An apparatus (100) for obtaining an image of the eye, has an alignment section (160) for aligning the pupil of the eye along an optical axis and a pupil sensor (170) for identifying pupil location and dimensions. An illumination section (112) has a light source (114) for providing an illumination beam and a spatial light modulator (125) for positioning and shaping the illumination beam according to the sensed location and dimensions of the pupil. An illumination beam partitioning mechanism (50) segments the illumination beam directed toward the pupil of the eye into at least one light-bearing segment (150) and at least one blocked segment. An actuator (132) coupled to the illumination beam partitioning mechanism (50) scans the at least one light-bearing segment (150) of the illumination beam across the pupil of the eye. An image sensor (146), aligned along the optical axis, obtains reflected light from the eye.

Abstract: An ophthalmologic appliance being an ultrasound probe positioning immersion shell for use in ultrasonic measurement of axial length of the eye ophthalmology and other procedures. Support members in an upper chamber and a lower chamber each provides accommodating support along and about a central axis of the ultrasound probe positioning immersion shell and about vertically spaced regions of ultrasound probes to provide for perpendicular alignment of ultrasound probes to the corneal plane. Vents in the chamber structure allow for introduction of fluid medium and for the expelling of air from the chambers to inhibit bubble formation.

Abstract: An apparatus (220) for obtaining a scanned image of an eye has a reference locator for pupil alignment apparatus along an optical axis. A pupil profiling apparatus for obtaining an outline of the pupil has a pupil profiling light source (176), a sensor (170) for detecting reflected light, and a control logic processor (104) for computing an outline of the pupil according to detected light. An illumination apparatus (112) for directing visible illumination into the eye has a spatial light modulator (125) for shaping an illumination beam according to the detected outline, a scanning element (229), and a camera (146) for obtaining the scanned image by sensing a portion of the reflected illumination.

Abstract: Visual displays of the geometry and/or topography of a portion of the eye is obtained from data generated during a number of angularly spaced scans taken across a meridional coronal section or of a marginal sector of the anterior surface of the eye, the data being processed for display, to thereby permit the optimization of the surgical placement and the configuration of lenses.

Abstract: A blade and holder combination for use with a microkeratome, and including means for improving mechanical stability when the blade is reciprocated during cutting, as well as a peripheral configuration minimizing local nonuniformities. Blades in accordance with the invention have a generally hemispherical posterior geometry that include an adjacent centralized ovoid coupling aperture and a small centrally disposed access slot that may include indicia for denoting blade type. The hemispherical geometry minimizes both local deformities and the processing needed to assure that the product functions to provide a clean, uniform surgical result.

Abstract: The scanning system of the invention includes a structure driven in rotation around a first axis, a structuremounted rotating on the structure around an axis parallel to the first axis, a structure for supporting an echographic probe mounted rotating on the structure around a third axis parallel to the axis, a coupling element between the structure and the structure and a coupling element between the support structure and the structure. This system being able to move the probe along a variable band arciform trajectory.

Abstract: An apparatus for ultrasound scanning of the eye is provided comprising a virtual center translocation mechanism that facilitates precise arcuate motion of an ultrasonic transducer to maintain focal distance from the eye and to maintain normality of the ultrasound beam with surfaces of the eye. The invention also provides a radius adjust mechanism for changing the radius of ultrasound scanning to facilitate positioning of the transducer focal point on selected surfaces of the eye. Centration optics are also provided, for aligning the ultrasound transducer with the Purkinje (or other optical or geometric) axis of a patient's eye. In addition the invention provides a hygiene barrier eyeseal for protection of the patient from disease propagation.

Abstract: The present invention relates to the use of a high frequency ultrasound transducer with long focal length for making a device and for implementing a method of echographic exploration of tissue or organs of the human or animal body. More particularly, the invention relates to using an ultrasound transducer having a nominal excitation frequency greater than 20 MHz, preferably lying in the range 50 MHz to 80 MHz, with long focal length, greater than 10 mm, preferably about 25 mm, for making a device for echographic exploration of the eyeball, in particular of the posterior segment of the eyeball, and more particularly of the macular region.

Abstract: Visual displays of the geometry and/or topography of a portion of the eye is obtained from data generated during a number of angularly spaced scans taken across a meridional coronal section or of a marginal sector of the anterior surface of the eye, the data being processed for display, to thereby permit the optimization of the surgical placement and the configuration of lenses.

Abstract: A hand-held pachymeter includes an ultrasonic probe capable of emitting ultrasonic pulses and capable of receiving echo signals of the ultrasonic pulses. The echo signals may include an echo signal from an anterior portion of a cornea of an eye and an echo signal from a posterior portion of the cornea. The hand-held pachymeter also includes a hand-held computing device and an expansion module that interfaces the probe to the hand-held computing device. The expansion module includes circuitry to produce digitized signals that correspond to the echo signals, and a memory which stores computer instructions to determine a thickness of the cornea based on the digitized signals. The computer instructions are executed by the hand-held computing device.

Abstract: Illumination unit for the generation of optical sectional images in transparent media, particularly in the eye.

Abstract: Featured is a device that provides a mechanism for imaging structure and/or tissue of a surgical site during and after performing a microsurgical procedure such as ophthalmic surgical procedures. Also featured are methods and systems related thereto. In the imaging method of the present invention using such a device includes positioning a high frequency ultrasonic signal transmitting and receiving apparatus imaging mechanism in close proximity to the area to be scanned/imaged (e.g., surgical site), so that the high frequency ultrasonic signal penetrates the tissue/structure of the surgical site being scanned. The reflected ultrasonic signals, are processed so as to yield high quality/high resolution images of the scanned tissue/structure. Further, the high resolution images are evaluated by the surgeon during the procedure to determine if the surgical approach should be adjusted.

Abstract: There is disclosed a method for analysis and therapy of the eye utilizing laser-induced ultrasound.

Abstract: On the side at hand of an optical probe, a whole rotation transfer connector rotates while being supported by a ball bearing and a slide bearing and, therefore, rotation is transferred to a flexible shaft. The relative position between the flexible shaft and an optical sheath is changed in accordance with the amount of screwing of a sheath stopping member on the side at hand into an outer cylinder by an external thread portion and an internal thread portion. When the optical sheath is moved furthermore, the flexible shaft is elongated due to elastic deformation because the length of the flexible shaft is regulated by the interval between a locking part of a locking member at the tip and a shaft stopping member. A tip housing is made to contact with the locking member while tension is applied to the flexible shaft by the rear end surface in the direction of the side at hand.

Abstract: An apparatus for ultrasound scanning of the eye is provided comprising a virtual center translocation mechanism that facilitates precise arcuate motion of an ultrasonic transducer to maintain focal distance from the eye and to maintain normality of the ultrasound beam with surfaces of the eye. The invention also provides a radius adjust mechanism for changing the radius of ultrasound scanning to facilitate positioning of the transducer focal point on selected surfaces of the eye. Centration optics are also provided, for aligning the ultrasound transducer with the Purkinje (or other optical or geometric) axis of a patient's eye.

Abstract: An apparatus for ultrasound scanning of the eye is provided comprising a virtual center translocation mechanism that facilitates precise arcuate motion of an ultrasonic transducer to maintain focal distance from the eye and to maintain normality of the ultrasound beam with surfaces of the eye. The invention also provides a radius adjust mechanism for changing the radius of ultrasound scanning to facilitate positioning of the transducer focal point on selected surfaces of the eye. Centration optics are also provided, for aligning the ultrasound transducer with the Purkinje (or other optical or geometric) axis of a patient's eye.

Abstract: The invention relates to a novel apparatus for the treatment of ocular disease, particularly glaucoma. The apparatus consists of a locating device to locate Schlemm's Canal within the anterior portion of the eye and a surgical tool to access the canal for treatment. The apparatus allows for guided, minimally invasive surgical access to Schlemm's Canal to enable surgical procedures to be performed on the canal and trabecular meshwork to reduce intraocular pressure. The apparatus may also deliver devices or substances to Schlemm's Canal in the treatment of glaucoma.

Abstract: An improved method and apparatus for conducting biometric high frequency ultrasound scanning of the human eye permits the subject to assume a seated position and to place the eye to be scanned in contact with the fluid medium contained in an eye cup. In a prefered embodiment, the eye cup is disposable after each use.

Abstract: An introducer sheath (30) having a short distal tip section (34,40) that is highly radiopaque. The distal tip section may be of FEP with 20% to 75% by weight tungsten particulate filler, and may be initially a separate member (40) and bonded to the sheath shaft distal end (32).

Abstract: In an inventive method for mapping the topography of an eye, elevation measurements of the eye are collected using a slit beam diffuse reflection system, such as an ORBSCAN™ device. An approximating b-spline surface is then fitted to the elevation measurements. Slope measurements of the eye are collected using a Placido-based reflective system, but the slope measurements are referenced to points on the b-spline surface, rather than to points approximated using the conventional constant curvature method, so the measurements have substantially improved accuracy. The elevation and slope measurements are then blended using weighted least squares fitting techniques. A new b-spline surface is fitted to the blended measurements, with the new surface having substantially improved accuracy in depicting the actual topography of the eye as a result of the elevation-improved accuracy of the slope measurements.