Abstract: A method of and device for acquiring in-vivo images or quantitative/qualitative data (perfusion, blood flow, vascularization, contrast enhancement, selective blood supply management) of interior parts of the human body (20) is described, using an imaging system (21) and including the steps of positioning the body (20) relatively to the imaging system (21), applying a respiratory resistance device (10) to the respiratory system of the body (20), and performing an image acquisition step during or concomitantly an inhalation/inspiration/suction or exhalation/Valsalva/expiration phase, during which the body provides suction or exhalation against a resistance as provided by the respiratory resistance device (10).

Abstract: A method for generating an alarm during the monitoring of a patient with the step of determining a minute volume (MVpat) of the patient, setting a minute volume lower limit (MVlow) and/or a minute volume upper limit (MVhigh), wherein the minute volume (MVpat) is cumulated by means of an increment function into a volume (Vdeficit_kum) when the measured value drops below the minute volume lower limit (MVlow) or exceeds the minute volume upper limit (MVhigh), and an alarm is triggered when the cumulated volume (Vdeficit_kum) exceeds a maximum allowable volume (Vdeficit_apn). Furthermore, the present invention pertains to a device for reducing clinically irrelevant alarms during the monitoring of a patient for carrying out the method according to the present invention.

Abstract: A resonance and articulation training device that includes a body with an open end and a closed end. A vertical tube is attached to the body near the closed end, and a pellet is located within the vertical tube. One or more holes along the body may be used to adjust the amount of airflow needed to lift the pellet. A mouthpiece or head joint from a musical instrument may be attached to the open end. Generating a tone with the mouthpiece or head joint creates an airflow in the body. If the airflow is sufficient, it may lift the pellet.

Abstract: A bi-directional flow sensor is adapted for reducing pneumatic noise during pressure sensing with a flow passing through the flow sensor. The flow sensor comprises a hollow, tubular member having a throat section disposed between a ventilator end and a patient end. A flow restrictor is disposed in the throat section and is adapted to measure differential pressure in the flow. A baffle is mounted at the ventilator end and is adapted to minimize non-axial flow at pressure taps located on opposing ends of the flow restrictor. The patient end includes a flow obstruction configured to promote uniform velocity across the flow at the pressure taps during exhalation flow from the patient end to the ventilator end. The flow sensor minimizes pneumatic noise to less than 0.1 LPM to allow accurate patient flow measurement and triggering of inhalation and exhalation phases at flow rates of 0.2 LPM.

Abstract: The invention relates to a spirometer for measuring pulmonary respiration of a test subject, comprising a body and a sensor unit, wherein the sensor unit can be interchanged with further sensor units. In a corresponding method, such a spirometer is operated with a sensor unit and the sensor unit is subsequently interchangeably replaced by a further sensor unit.

Abstract: The invention application presents a fast, efficient, reproductive alternative of a non-invasive method for diagnosing the severity of heart failure based on a specific biomarker. An additional object of the present invention is a collector device for the biomarker from exhaled breath that is portable, simple, low cost and does not need to run on electric power. This invention advantageously permits the replacement of invasive diagnosis methods, favoring the patient's comfort in addition to the agility and speed of medical attention at hospitals, and may become a standard method for all suspected cases of circulatory disease and heart failure and, more specifically, decompensated heart failure.

Abstract: Vital sign monitoring is especially challenging in small animals, given the high metabolic rates and small volumes under consideration. An embodiment of the present invention includes a unique nose-cone design and associated instrumentation which allows for measurement of respiratory parameters, including anesthesia gas concentration, inspiratory and expiratory O2, and inspiratory and expiratory CO2 (capnometry). Such instrumentation facilitates a physiologic assessment of small animals undergoing general anesthesia, an increasingly important consideration as small animals play a greater role in in vivo biomedical studies. In addition, the techniques proposed herein are suitable for measurement on small respiratory volumes associated with neonatal monitoring.

Abstract: Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual.

Abstract: The present invention provides a method for measuring FeNO in a subject, wherein the FeNO data derived from a subject patient is normalized to compensate for variations of FeNO with flow rate.

Abstract: A positive oscillatory expiratory air pressure respiratory therapy device which is adapted to receive a nebulizer for administering aerosolized medicant for selective administration during oscillatory positive expiratory pressure (PEP) therapy.

Abstract: A disposable volume spirometry apparatus and non-contact measurement system is described. The spirometry system includes an expandable disposable volume spirometry apparatus, a remote non-contact sensor, memory, and a processor. The remote non-contact sensor captures images associated with the expandable disposable volume spirometry apparatus. The memory stores the captured images. The processor is operatively coupled to the memory and determines a volume for the expandable disposable volume spirometry apparatus by analyzing the captured images.

Abstract: Methods and systems for lung volume reduction of a patient are described. The methods include implanting a flow control device in a bronchial passageway of the lung. The flow control device regulates fluid flow through the bronchial passageway and includes a valve protector that at least partially surrounds a valve member. The valve protector has sufficient rigidity to maintain the shape of the valve member against compression.

Abstract: A medical respiratory apparatus includes a chamber (10) which is at least in part at least translucent. The chamber (10) includes a float member (12) formed of an inert material and contains, in use, a fluid intended for inhalation. The float member (12) is adapted to float upon the fluid intended to be contained within the chamber (10) and has a peripheral dimension adjacent, but less than, the internal peripheral dimension of the chamber (10). At least the outer peripheral surface of the float member (12) has a coloration distinct from that of the fluid to be contained within the chamber such that the level of the fluid within the chamber (10) can be readily observed.

Abstract: A one-way air flow valve includes one-way inspiration and expiration valve assemblies which have a same structure, are connected to each other in parallel, and are arranged opposite to each other, so that valve plates provided in the one-way inspiration and expiration valve assemblies, respectively, are open in directions opposite to each other, and a connection part including a mouthpiece provided at one side of the inspiration and expiration valve assemblies to allow an examinee to inhale or exhale air. One end of the inspiration valve assembly is connected with a gas tank, one end of the expiration valve assembly is connected with a gas density analyzer, and the inspiration and expiration valve assemblies include a valve and suction and discharging tubes coupled with one side and an opposite side of the valve, respectively.

Abstract: A pulsed breathing device has a base unit containing a motor and control circuit and a detachable head unit containing a valve, driven by the motor, which can interrupt the flow of air being breathed.

Abstract: Techniques are provided for detecting the circadian state of a patient using an implantable medical device based on selected blood carbon dioxide (CO2) parameters. In one example, the implantable device tracks changes in end tidal CO2 (etCO2) levels and changes in maximum variations of pCO2 levels per breathing cycle (?cycleCO2) over the course of the day and determines the circadian state based thereon. It has been found that average etCO2 levels are generally highest and average ?cycleCO2 levels are generally lowest while a patient is asleep and opposite while a patient is awake. Hence, by tracking changes in average etCO2 and ?cycleCO2 levels over the course of the day, circadian states can be detected. Minute ventilation and activity levels are used to assist in the determination of the circadian state. Additional techniques are directed to detecting the stage of sleep.

Abstract: A device for detecting the flow of a gas from an opening comprising a chamber with an inlet, the chamber carrying a pressure displaceable member with an inner face exposed to the interior of the chamber and an outer face exposed to the ambient pressure such that the member is displaced as a result of the differential of the pressures; and a method of using the device and a method of manufacturing the device.

Abstract: A sensing apparatus with a connector, a sensor lead and a sensor module with a spacer placed over electrodes that have been deposited on a substrate. The spacer may have a space for receiving an enzyme. End portions of the sensor module may be encapsulated, such as with molded beads. A sensor lead may attach to the sensor module and may have an outer tubing that passes over the module and attaches to the beads at the end of the sensor module. The sensor lead may also attach to the connector such that the sensing apparatus may be electrically coupled to a pump, electronics or other devices. The sensing apparatus may be implanted into a vein or artery.

Abstract: An improved flow based incentive spirometer operable through a range of user set flow rates and being adapted to receive a supplemental flow of Oxygen without requiring any change in the calibration of the device or effecting the patient's monitoring of usage. In this manner the spirometer may be utilized by a range of patients having quite distinct therapy needs. The device also features an integral information display receptacle in the base for storage of operational instructions. A portion of the base is transparent to that the information contained in the storage receptacle can be viewed by a patient while the device is in use, thereby permitting a patient to observe such things as the instructions for proper use of the incentive spirometer while using the device.

Abstract: This invention relates to instruments, particularly medical and research instruments that are used for assessing gas volumes of cavities, particularly, cavities that may exhibit a compliance to changes in pressure, such as in vivo volumes of the lung, thorax, oropharynx and/or nasopharynx.

Abstract: Methods are provided for smoothing input signals having rapidly changing amplitudes, such as EMG signals from the tongue, which are detected by an intraoral device. One method calls for amplifying the EMG signals, converting the EMG signals to digital format, providing a moving average of the amplitudes of the EMG signals utilizing a moving the average processor, and windowing the averaged signals to discrete and stable amplitude levels. An adaptive moving average technique may be utilized, which includes a plurality of parallel moving average processes and a differentiator which determines which process is used, depending on the rate of change of the signal amplitude. Another method calls for the use of a plurality of moving average processes in series which calculate the moving average of the same number of signals as a single moving average process, but has a faster response time. An intraoral device is used to detect the EMG signals. The intraoral device includes acrylic maxillary and mandibular splints.

Abstract: In a lung therapy method, hyperpolarized gas is administered for one breath to a subject, and a magnetic resonance scan of at least one lung of the subject is conducted. The data obtained from the scan are evaluated, specifically to determine the extent and distribution of infusion of hyperpolarized gas in the lung, as an indication of the alveolae in the lung which are open. Based on the evaluation of the data obtained in the magnetic resonance scan, a determination is made as to whether administration of a surfactant is necessary in order to improve opening of the lung. If a surfactant is administered, the procedure can be repeated to obtain an updated dataset, which can be evaluated to determine whether the administered surfactant has been effective.

Abstract: An improved incentive spirometer having a modular goal recording counter (GRC) releasably attached thereto for enabling a patient to view the number of times a predetermined respiratory therapy inhalation exercise has been properly performed. The GRC also includes a coaching lamp to facilitate the patient's maintaining the desired flow rate of inspiratory air for a predetermined time period. The GRC is operational in one mode to initiate a count of the number of successful exercise completions beginning with “0”, and in another operational mode to retain and recall the count of the number of successful exercises previously completed. The operation of the GRC is controlled by a microcontroller which controls the operation of the GRC and the electrical circuit connected thereto is designed to minimize the power requirements of the components when the GRC is placed in the retain and recall mode of operation.

Abstract: A breathing apparatus having a main body with a generally cylindrical inner cavity. The main body has a main aperture for the user to breath into and at least two sets of outer openings. An inner cylinder is coaxially disposed within the inner cavity of the main body and is adapted to move relative to the main body. The inner cylinder has an open end adjacent the main aperture, and at least two sets of inner openings selectively matable with the openings in the main body upon movement of the inner cylinder with respect to the main body. By selecting the appropriate alignment of openings, either resistive, percussive, or pulsing breathing exercises can be performed.

Abstract: A device for measuring the resistance of the respiratory tract with the interrupter method consists essentially of a housing (2) which comprises an air passage (3), and of a closing arrangement (5) for temporarily closing the air passage (3). The closing arrangement (5) may be operated via drive means (8). The drive means (8) are arranged and/or designed such that they can be accelerated in a load-free manner from a rest position (R) into an effectual condition (W). In the effectual condition (W) the drive means (8) engages with the closing arrangement and move the latter from a home position (A) into a closing position (V). With this, it is essential that at the point in time of the coming into engagement of the drive means (8) and the closing arrangement (5), the drive means has a certain energy content.

Abstract: The utility and elements of a metered dose inhaler, a spacer device and a peak respiratory flow rate meter are combined in a single personally portable device. The present device provides a tool for improving compliance of patients with asthma and other pulmonary disorders with their prescribed treatment regimens. This is accomplished in by combining therapeutic and diagnostic devices in a single personal device.