Abstract: A fabric sleeve that is worn on the finger and is designed to be used for the Niddah inspection. The sleeve comprises a tubular piece of fabric that is closed at one end and has an opening at the other end into which the user inserts her finger to perform the Niddah inspection.

Abstract: Estrus of animals and particularly sows is determined for planning of a preferred time period of insemination by a sensing system arranged to detect standing of the animal. Data from the sensing system is collected and analyzed using an algorithm and information that is displayed on an indicating system to provide an indication to a worker of the time period of estrus and ovulation and of a useful insemination time period and a preferred insemination time period of the animal. The indicating system includes a countdown clock to the preferred time period of insemination. In the event that the insemination fails, an indication is provided about whether the actual time of insemination occurred at the preferred time of insemination indicated to the worker. When estrus is completed, a confidence level is provided about the likelihood of success based on the position of the actual time of insemination relative to ovulation.

Abstract: A data logger device for in-situ measurement of one or more physical parameters comprising a power source; one or more sensors for measuring the one or more physical parameters; a data store for storing representations of at least some of the measured values of the one or more physical parameters; control logic arranged to write the representations of at least some of the measured values to the data store and arranged to read data from the data store during data transmission; an antenna; and a transmitter coupled to the antenna and configured to transmit the stored data by passive transmission. The physical parameter may be temperature. A processor may estimate basal body temperature by extrapolating from a plurality of temperature readings during a sleep period. The estimated basal temperature may be used to form an indication of ovulation.

Abstract: The present disclosure suggests an apparatus for determining at least one parameter in the vaginal channel of a user. The apparatus comprises a flexible pessary and a measurement unit comprising at least one sensor for measuring the at least one vaginal parameter. The measurement unit is reversibly mountable to the flexible pessary.

Abstract: A system and method for monitoring a health parameter of a vehicle occupant where an occupant profile is created that identifies a biological parameter to measure, a measure health parameter to report on and corresponding thresholds that trigger an alert. A vehicle has an integrated sensor that measures the biological parameter according to the profile and provides a signal of the measured biological parameter. A computing device records the measured biological parameter and derives the measured health parameter from the measured biological parameters. If the measured health parameter passes a threshold, then an alert is triggered, and the occupant or interested party is notified.

Abstract: A method, including measuring a force exerted by a probe on tissue of a patient and measuring a displacement of the probe while measuring the force. The method further includes detecting a tenting of the tissue responsively to a relation between the measured force and the measured displacement.

Abstract: A method of providing information relating to the fertility of a female mammal comprising the steps of: (i) taking multiple temperature readings from the female mammal during an extended period; (ii) identifying and disregarding temperature readings having one or more characteristics of irrelevant or faulty data; (iii) obtaining one or several representative temperature values for the extended period; (iv) repeating steps (i) to (iii) over multiple extended periods; (v) analyzing the representative temperature values obtained over multiple extended periods for one or more patterns in the representative temperature values indicative or predictive of ovulation in order to provide information relating to the fertility of the female mammal to a user, wherein the representative temperature values are not the maximum or minimum temperature readings obtained for the extended period; and related uses and apparatus.

Abstract: A system for predicting ovulation cycles by employing an application running on a mobile communication device such as an iPhone®, a Blackberry™, or an Android-based smartphone is provided. The system includes a basal body temperature thermometer coupled to a mobile communication device. The thermometer takes temperature measurements, encodes the temperature measurements and transmits the encoded temperature measurements to the mobile communication device. The mobile communication device receives and decodes the encoded temperature measurements. The mobile communication device includes an application that analyzes the decoded temperature measurements to determine whether they are satisfactory or unsatisfactory, provides feedback to a user in real-time and provides an ovulation prediction.

Abstract: A method of determining the phase of an estrous cycle that a mammal is in at a given time that a biological sample is obtained from the mammal is provided. The biological sample obtained from the mammal is combined with at least one flavonoid pigment that reacts with the biological sample on a hydrophobic surface to provide a color response. The estrus phase of the estrous cycle has a corresponding color response that is distinguishable from the color response of each other phase of the estrous cycle to an unaided human eye. The corresponding color response is correlated to the estrus phase of the estrous cycle.

Abstract: A system for customized prediction of a menstruation period or a fertility period is provided. The system includes a vital information measurer for measuring vital information about a user, a basic menstruation information generator for calculating the first day of menstruation or an ovulation day using the vital information received from the vital information measurer and outputting the first day of menstruation or the ovulation day as basic menstruation information, a menstruation cycle modeler having a menstruation cycle model representing a menstruation cycle as a function with a predetermined period, and a model parameter estimator for estimating and compensating a menstruation cycle parameter of the menstruation cycle model using the basic menstruation information received from the basic menstruation information generator.

Abstract: A system, method and apparatus for determining a physiological condition within a mammal based on pH and/or temperature measurements. In one aspect, the invention is directed to an apparatus for measuring a physiological condition within a mammal comprising: a tubular housing extending along a longitudinal axis from a distal end to a proximal end, the housing having an internal cavity; a first opening in the elongated housing forming a first passageway into the internal cavity; an ion-sensitive field effect transistor (ISFET) for measuring pH within a body lumen of the mammal, the ISFET positioned in the internal cavity, the ISFET aligned with the first opening so that at least a portion of the ISFET is exposed via the first opening; and a first seal between the ISFET and the housing forming a hermetic seal about a perimeter of the first opening.

Abstract: Methods and apparatus for interpreting vaginal measurement data by electronic means without the need for the user to take part in the data interpretation process. More specifically, an intelligent probe monitors folliculogenesis and correlates the ovarian function data to probe profile characteristics of the female reproductive cycle. A fertile window is defined with reference to the correlation between folliculogenesis and probe cyclic profiles.

Abstract: The invention includes a system and processes to gather and analyze data to monitor, track, and provide care. The major subsystems of the invention include the Medical Digital Assistant (“MDA”), Server, Monitoring Devices, Dispensing Devices, Server, Dashboard, and Application Software. The invention includes the method for conducting data acquisition, monitoring, analysis, and reporting to diagnose and treat medical conditions such as diagnosing and treating specific medical conditions such as fertility and congestive heart failure.

Abstract: An object of the present invention is to provide a test/diagnosis method for fertility which allows the estimation of the possibility of leading to pregnancy based on the ability of sperm to fuse with an egg and the identification of a cause of infertility; and a polynucleotide and a fertility testing kit which are used in the method.

Abstract: The method is for monitoring a childbirth process of a pregnant woman. A plurality of cervix dilatation data and fetal positioning data are obtained and fed to a device. A plurality of lactate concentrations is measured at time intervals. The measured lactate concentrations are shown on a display of the device at the time intervals to show a trend of the lactate concentrations. The cervix dilation data and the fetal positioning data are also shown on the display. The lactate concentrations are evaluated to determine whether the lactate concentrations are rising to indicate that an individual lactate threshold value of the pregnant woman has been exceeded. The medical practitioner may also evaluate the cervix dilation data and the fetal positioning data.

Abstract: Access to key diagnostic medical devices requires pre-approval by a screening physician. A computer-implemented system and method for mediating patient-initiated physiological monitoring and ensuring appropriate follow up, bypassing the need for a screening physician, are provided. A request for a medical monitoring device from a patient at a point of prescriptive medicine dispensing is entered. The patient is enrolled in a medical service network that includes healthcare providers and medical services, and one or more on-call prescribing physicians. The patient is interfaced in real time with one of the prescribing physicians. Upon physician approval, the monitoring device is dispensed to the patient at the point of dispensing. Following monitoring, data from the monitoring device is retrieved for the medical service network. The retrieved data is evaluated for medical concerns.

Abstract: A vaginal probe for acquiring and correlating vaginal measurement data with folliculogenesis in a female for prediction of fertility.

Abstract: Embodiments of the present invention are directed to a device and method for identifying estrus in production animals by detecting one or more standing mounts with a single device.

Abstract: An apparatus for detecting the reproductive status, in particular the oestrus cycle, of a mammal, comprising detecting means (10) to detect a blood amount perfused in a predetermined region of the vagina canal of a mammal, and generating a corresponding main signal (20); the apparatus (1) further comprises a processing unit (40) associated with said detecting means (10) to determine the reproductive status of said mammal depending on said main signal (20). Also disclosed is a method of detecting the reproductive status, in particular the oestrus cycle, of a mammal.

Abstract: Embodiments of the present invention are directed to a device and method for identifying estrus in production animals by detecting one or more standing mounts with a single device.

Abstract: A method for detecting the onset of ovulation in a female mammal is provided. The method includes contacting mouth air of the female mammal with an arylmethane test chromogen in an amount effective to undergo a rapid and detectable color change in the presence of one or more volatile sulfur compounds. The color of the test chromogen is compared to a control color that corresponds to a pre-ovulatory sulfur content. The difference in color between the test chromogen and the control color is correlated to the onset of ovulation.

Abstract: A system for sensing vaginal conditions or for affecting vaginal or body conditions in a mammal. The system includes a portable probe unit and a separate controller unit, both of which include two-way communication devices to both transmit signals to, and receive signals from, each other, wirelessly and in real time. The substantially smooth and sealed outer surface of the cylindrical body of the probe unit has a rounded end and is dimensioned to permit comfortable and repeated insertion into, removal from, and containment entirely within a mammal's vagina. The probe body has a device substantially flush with its outer surface and configured to deliver electrical pulses, receive electrical pulses, sense or sample vaginal conditions and/or deliver medication.

Abstract: A method of determining breeding status in animals by (a) determining a breeding event (cyclicity, mounting, pregnancy, open) time, (b) providing an estrus or other breeding event detection apparatus, (c) affixing the estrus detection apparatus at a predetermined location on a female animal at a predetermined application time prior to the breeding event time, and (d) monitoring the estrus detection apparatus for activation thereof. An indicator apparatus is provided for use in indicating when an animal is in estrus. The apparatus is configured to be affixed to the rump of an animal to detect and indicate when the animal has been mounted and, thus, when the animal is in estrus. The apparatus is affixed to the animal by an adhesive layer. Layered on the top surface of the adhesive layer is an indicator layer that is in turn covered with a floodcoat layer. The floodcoat layer is adapted for removal upon the mounting of the first animal by a second animal.

Abstract: A system, method and apparatus for determining a physiological condition within a mammal based on pH and/or temperature measurements. The invention is for determining vaginal health and/or fertility status in a female mammal based on pH and/or temperature measurements of vaginal and/or cervical fluids or tissue. The invention is suited for taking either in vivo or external measurements. In one aspect, the invention is an apparatus comprising an elongated probe portion and a handle portion. In one embodiment, the circuitry of the apparatus is strategically split between the probe portion and the handle portion to facilitate a plug-and-play type of device. In another embodiment, an elongated probe is provided that has a hermetically sealed internal cavity that houses the circuitry while leaving the temperature sensor and the pH sensor exposed for direct contact with the desired biological fluid. In a further embodiment, an ISFET is used as the pH sensor.

Abstract: A convenient and highly accurate intravaginal device with wireless sensors for monitoring fertility and sexual health of humans and animals is proposed. Sensors in the intravaginal device measure fertility and sexual health and via wireless transmitter send this information to a terminal on which the information is processed and displayed in convenient form.

Abstract: Improvements in a diagnostic system for determining and/or monitoring a physiological condition in a female mammal are disclosed. The diagnostic system includes hardware and software, and comprises algorithms for the recognition of predetermined patterns of data values, said algorithms being applied to said current daily data value and said stored daily data values by said microprocessor means, said microprocessor means controlling said display means to display characters representing one of several states of the mammal in response to recognition of a corresponding one of said predetermined patterns, wherein the algorithms are capable of determining, for example and substantially automatically, variables that can be used to define the beginning of the fertile cycle of the mammal, the end of the fertile cycle of the mammal and the most fertile day of the mammal. The improvements of the present invention involve a novel user interface providing display of the physiological condition over time to the user.

Abstract: Methods of monitoring the ovulation cycle of an animal by detecting specific analytes in body fluids, computer program products, devices, data processing systems, and kits for monitoring the ovulation cycle and determining the fertility of female mammals.

Abstract: This invention provides methods and compositions for testing for pregnancy and non-pregnancy in ungulates and non-hoofed ruminates. The tests provided by this invention are useful during a time that coincides with the estrus cycle during which breeding occurs or the first estrus cycle after breeding of a non-pregnant animal. The tests provided by this invention are useful in estrus and ovulation synchronization programs, with pregnancy testing useful at a time allowing for resynchronization of non-pregnant animals within the first estrus cycle. The tests provided by this invention assay for the presence, absence, or level of a selected IFN-?-induced protein in a sample from a female animal. The tests of this invention are useful for testing cells, blood, plasma, serum, cells, milk, nasal secretions, ocular secretions, vaginal secretions, urine, and saliva samples. The tests provided by this invention are immunoassays.

Abstract: A wiping device for wiping the surface of a cavity, comprising an implement having a distal end dimensioned and configured with a rounded tip to facilitate insertion of the device into the cavity, the implement also having a proximal end configured for manually grasping the implement and for inserting the distal end of the implement into the cavity, and a flexible wiping cloth configured to be received over the distal end of the implement, to conform to its rounded tip, and to define a lower edge to be releasable engaged by said implement in order to be releasably retained on the implement.

Abstract: Manual techniques for monitoring animal ovulation cycle have been used commercially to determine the best time to breed animals. Techniques using heat as an indicator for ovulation do not always correspond to ovulation. The present invention provides methods, apparatus, and kits for monitoring and predicting ovulation using an automated hand-held device, incorporating a computer and probe for detecting physical changes in the animal body fluid. Changes in electrolyte levels are detected as alterations in resistance which corresponds to specific intervals in the ovulation cycle. The present invention provides a rapid, low cost means for monitoring mammalian ovulation cycles and a tool for use in artificial insemination, especially in assessing large populations of animals.

Abstract: Method and device for the management of lactating animals wherein the reproduction stage of an animal is correlated with the lactation stage of the animal. A state of the animal is determined by means of automatically obtained sensor data. The state of the animal is graphically illustrated.

Abstract: A method for tissue bioassay comprising the steps of placing in the vagina of a female mammal an elongated probe having at least two electrodes positioned close to an insertion end of the probe, none of the electrodes extending around the entire periphery of said probe and at least one of then being metallic, applying across the electrodes an alternating voltage of relatively low peak-to-peak amplitude, measuring across the electrodes a value representative of the phase of the reproductive cycle of the female or the hormonal status of the fornix epitheliurn, and comparing that value with at least one reference value. A probe for practicing this method also is disclosed.

Abstract: A biological information measurement device stores, in a storage unit, biological data representing data of calculated biological information and measurement date data in association with each other. The biological information measurement device displays, as measurement frequency specifying information, information for specifying frequency of day(s) when the measurement was conducted, in a prescribed period from a current date based on a plurality of pieces of measurement date data stored in the storage unit and an output from a time keeping unit.

Abstract: A method and apparatus for assessing fertility in mammalian females comprising sampling cervical-vaginal fluid, measuring one or more of the sample's viscoelastic properties, and evaluating the measurement to determine fertility. Preferable embodiments of the current invention may utilize measurement of the viscoelastic property of die swell ratio, or other viscoelastic properties of cervical-vaginal fluid.

Abstract: A system, method and apparatus for determining a physiological condition within a mammal based on pH and/or temperature measurements. In one aspect, the invention is directed to a method of determining vaginal health and/or fertility status in a female mammal comprising: a) inserting a probe into a vagina of the female mammal, a distal portion of the probe comprising an ISFET for measuring pH and a temperature sensor for measuring temperature; b) measuring pH and temperature with the ISFET and the temperature sensor of the probe; c) transmitting signals indicative of the measured pII and temperature to a microprocessor; d) the microprocessor generating an output signal indicative of the fertility and/or vaginal health status in the female mammal based on the signals indicative of the measured pH and temperature; and e) communicating the output signal to a user.

Abstract: A system, method and apparatus for determining a physiological condition within a mammal based on pH and/or temperature measurements. In one aspect, the invention is directed to a method of calibrating an apparatus for taking in vivo pH measurements comprising: a) providing a probe having an elongated housing extending along a longitudinal axis, a well formed in a top edge of the elongate housing for holding fluids, a pH sensor located on a floor of the well, the well located at a distal portion of the elongated housing; b) positioning the distal portion of the elongated housing on a base of a removable cap, the removable cap having a lid in an open position; c) supplying a liquid buffered to a known pH to the well and in contact with the pH sensor; d) moving the lid of the removable cap to a closed position so that the distal portion of the elongated housing is enclosed in a cavity of the removable cap, the cavity being substantially free of visible light; and e) calibrating the pH sensor to the known pH.

Abstract: A system, method and apparatus for determining a physiological condition within a mammal based on pH and/or temperature measurements.

Abstract: A method of providing information relating to the fertility of a female mammal comprising the steps of: (i) taking multiple temperature readings from the female mammal during an extended period; (ii) identifying and disregarding temperature readings having one or more characteristics of irrelevant or faulty data; (iii) obtaining one or several representative temperature values for the extended period; (iv) repeating steps (i) to (iii) over multiple extended periods; (v) analysing the representative temperature values obtained over multiple extended periods for one or more patterns in the representative temperature values indicative or predictive of ovulation in order to provide information relating to the fertility of the female mammal to a user, wherein the representative temperature values are not the maximum or minimum temperature readings obtained for the extended period; and related uses and apparatus.

Abstract: A system for predicting a woman's current position in her menstrual or ovulation cycle includes a baseline voice characteristics storage module in which first set of characteristics of the woman's voice at a known time relative to her menstrual or ovulation cycle is stored, an analysis module for receiving for analyzing a voice sample from the woman and generating a second set of characteristics of the woman's voice, a comparison module for comparing the first and second sets of characteristics, and a results module for providing a prediction of the woman's current position in her menstrual or ovulation cycle based on the comparison.

Abstract: A method of providing visual indications relating to various phases of a woman's menstrual cycle and an apparatus for providing visual indications relating to various phases of a woman's menstrual cycle are provided. As many as ten different types of beads are utilized in the method and apparatus of the present invention to provide the desired visual indications. Different beads are placed on a string each day during the woman's menstrual cycle depending upon the phase of the woman's menstrual cycle and other events observed during such phases.

Abstract: A system and method are provided for transducing vaginal conditions, affecting vaginal or body conditions, and/or stimulating perineal musculature and nerves. A separate, portable, non-implanted intravaginally containable combination probe and transceiver is provided that can sense vaginal conditions, can deliver signals or medication, and/or can stimulate perineal musculature and nerves. This probe unit is provided with 2-way wireless communication for transmitting information that is transduced and for receiving control and programming signals. In addition, a separate combination controller and transceiver is provided for wirelessly sending signals to the probe unit and for receiving signals therefrom. A real time wireless signal feedback loop is thus provided between the controller and the probe and/or external devices, networks and databases.

Abstract: Methods and apparatus for interpreting vaginal measurement data by electronic means without the need for the user to take part in the data interpretation process. More specifically, an intelligent probe monitors folliculogenesis and correlates the ovarian function data to probe profile characteristics of the female reproductive cycle. A fertile window is defined with reference to the correlation between folliculogenesis and probe cyclic profiles. Data stored within the apparatus can be downloaded into an external display appliance or data analysis unit. Another aspect of the invention allows for continuous layout of the memory of preceding cycles in the inventory of the apparatus, retaining the most recent while erasing the most distant stored data.

Abstract: A system and method for tracking and informing about a physical, emotional, or physiological cycle, such as a menstrual cycle, includes at least one definition entry and at least one date indicator. Each definition entry defines indicia such as color to represent a stage of a physical, emotional, or physiological cycle. Each date indicator includes a date section and a tracking section corresponding to each date section. The date section of the date indicator indicates at least one date, wherein the tracking section is capable of being marked so as to indicate indicia corresponding to a definition entry to signify the stage of the physical, emotional, or physiological cycle for each date. According to one embodiment, the date indicators are arranged according to phases of the moon to allow correlation of a user's cycle to the lunar cycle.

Abstract: The invention relates to a device for determining the physiological state of female mammals related to procreation. The inventive device comprises a sealed housing (2) which is introducible into the reproductive tract of a female mammal and comprises at least two sensors (3) placed on the periphery thereof and/or therein for capturing different physical and/or psychological data items and a power supply means for enabling the device to be independently operational. Said housing (2) is also connected to means for processing data items collected by said sensor(s) (3) and to means for transmitting the collected data items and/or results obtained by data processing.

Abstract: A method and device to predict ovulation in a female human by measuring changes in the concentration of a number of ions in eccrine sweat is disclosed. The concentration, or changes in concentration, of one or more ions are determined throughout the day and analyzed against predetermined patterns in order to predict ovulation one to five days in advance. This permits the user to more accurately determine commencement of the fertile phase, which for female humans is generally considered to be about four days prior to ovulation to one day after ovulation. The concentration of the ions measured include sodium (Na+), potassium (K+), ammonium (NH4+), calcium (Ca2+), chloride (Cl?) and nitrate (NO3?). To further increase the accuracy of the reading, a large number of readings can be obtained throughout a day and statistically analyzed to determine the change over time. In addition, the concentration of two or more ions can be obtained to increase accuracy.

Abstract: An ovulation-prediction device with an image processing system containing a transmissive test platen for placing saliva samples and a miniature camera for capturing the image of saliva sample at dried state for analyzing the increase of salt content for predicting ovulation. An image processing method with an algorithm described for removing noise in a saliva sample for calculating the density of dark pixels which represents salt content in the sample. A Density Index is defined. Trend curve of Density Index vs. day is established based on the daily saliva analysis in a woman's menstrual cycle for predicting days from the ovulation. Also illustrated are applications of the image processing system in an electrical toothbrush, a dental massager and a portable compact device using a disposable tape cassette for testing saliva samples.

Abstract: Methods and apparatus for interpreting vaginal measurement data by electronic means without the need for the user to take part in the data interpretation process. More specifically, an intelligent probe monitors folliculogenesis and correlates the ovarian function data to probe profile characteristics of the female reproductive cycle. A fertile window is defined with reference to the correlation between folliculogenesis and probe cyclic profiles. Data stored within the apparatus can be downloaded into an external display appliance or data analysis unit. Another aspect of the invention allows for continuous layout of the memory of preceding cycles in the inventory of the apparatus, retaining the most recent while erasing the most distant stored data.

Abstract: An apparatus for detecting the reproductive status, in particular the oestrus cycle, of a mammal, comprising detecting means (10) to detect a blood amount perfused in a predetermined region of the vagina canal of a mammal, and generating a corresponding main signal (20); the apparatus (1) further comprises a processing unit (40) associated with said detecting means (10) to determine the reproductive status of said mammal depending on said main signal (20). Also disclosed is a method of detecting the reproductive status, in particular the oestrus cycle, of a mammal.

Abstract: Estrus and ovulation of animals and particularly sows is determined for planning of a preferred time zone of fertilization by a sensing system arranged to detect standing of the animal. Data from the sensing system is collected and analyzed using an algorithm and information that is displayed on an indicating system to provide an indication to a worker of the time zone of estrus and ovulation and of a useful fertilization time zone and a preferred fertilization time zone of the animal. The indicating system includes a countdown clock to the preferred time zone of fertilization. In the event that the fertilization fails, an indication is provided about whether the actual time of fertilization occurred at the preferred time of fertilization indicated to the worker. When estrus is completed, a confidence level is provided about the position of the actual time of fertilization relative to ovulation.

Abstract: The present invention provides a fixed focus handy ovulation tester, the said ovulation tester comprising an inner casing (1), having a top and a bottom end; a controllable 5 illuminating assembly (2) located inside the inner casing and near the bottom end of the inner casing and being sealed at the bottom by a bottom face plate (3) and a fixed focus eye piece assembly (4) having a bottom inner portion for placing a biological specimen and a top outer portion for viewing the specimen being removably located at the top end of the inner casing.