Abstract: A cassette for collecting a tissue sample. The cassette includes a housing configured to be removably coupled with a manifold receiver of a medical fluid collection system. The housing defines a first void space, a second void space, and an outlet opening. A catch tray is removably positionable within the first void space and includes a screen defining porous features for collecting the tissue sample. A filter element separate from the catch tray is disposed within the second void space. The housing may include a cap portion defining the first void space, and a shell portion coupled to the cap portion and defining the second void space. The cassette may be simultaneously operable in a tissue collection mode in which fluid is suctioned across the catch tray to collect the tissue sample, and a bypass mode in which the fluid is not suctioned across the catch tray.

Abstract: A biopsy device includes a body, a needle, a cutter, and a cutter drive mechanism. The needle extends distally from the body. The cutter is movable relative to the needle to sever a tissue sample. The cutter drive mechanism is driven by a rotary drive cable and is configured to both rotate and translate the cutter. The cutter drive mechanism is further configured to reverse the transition direction of the cutter wile the drive provided by the rotary drive cable is in a continuous rotary direction.

Abstract: A method and system for controlling an ultrasonically driven handpiece employable in an ocular surgical procedure is provided. The method includes operating the ultrasonically driven handpiece in a first tip displacement mode, such as a longitudinal mode according to a first set of operational parameters, and enabling a user to alter the ultrasonically driven handpiece to employ a second tip displacement mode, such as a transversal or torsional mode, using a second set of operational parameters. Enabling the user to alter performance of the handpiece comprises the user being enabled to dynamically select operational parameters for the first tip displacement mode relative to the second tip displacement mode by using, for example, a switching apparatus such as a footpedal.

Abstract: A rotary surgical tool is provided and has an effector or cutter that is usable to remove or otherwise modify tissue such as bone. The tool includes a motor coupled to the effector with a single piece shaft that is integral with the effector and also serves as the motor output shaft.

Abstract: A hand held instrument for harvesting a biopsy sample is provided. The instrument includes a housing, an annular blade on a distal end of said housing for cutting axially cutting a biopsy, a transverse blade unit for transversely cutting the biopsy, and a plunger unit positioned within the housing ejecting the biopsy sample away from inside the housing after said biopsy sample has been transversely cut.

Abstract: A biopsy device is configured such that: a first retraction of a charge handle moves a cannula slide and a sampling slide in unison in a proximal direction to charge and retain a sampling spring in a charged state, and to charge a vacuum system; a first return of the charge handle returns the charge handle to a home position; a second retraction of the charge handle moves the charge handle to a retracted position; a second return of the charge handle to the home position moves the cannula slide to charge a cannula retract spring and retain the cannula retract spring in a charged state; and a third retraction of the charge handle moves the carriage assembly as a whole in the proximal direction to charge a prime pierce spring and to retain the prime pierce spring in a charged state.

Abstract: An arthroscopic device is used with a hand piece having a motor drive with a rotating drive shaft. An elongate probe extending along a longitudinal axis and includes a proximal hub on a proximal end. The proximal hub detachably couples to the hand piece, and an openable-closeable jaw structure is disposed on a distal end of the elongate probe. A conversion mechanism carried by the hub converts a rotational motion of the motor drive shaft to a longitudinal motion of an actuator member. The actuator member drives the jaw structure between jaw-open and jaw-closed positions to resect bone and other hard tissues.

Abstract: An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool.

Abstract: Suction devices and methods for fine needle aspiration. Certain embodiments include an inner tubular member and a piston disposed within an outer cylinder. In particular embodiments, a vacuum is created in a portion of the interior volume of the outer cylinder and in the interior volume of the inner tubular member when the piston is moved toward the distal end of the inner tubular member.

Abstract: A fluid reservoir includes a housing having a body, a leading end, and a trailing end enclosing a fluid chamber storing fluid therein, sealed inflow and outflow ports disposed at the leading end of the housing, and a heat exchanger disposed at the trailing end of the housing. An ultrasonic surgical instrument includes a housing defining a barrel portion and a fixed handle portion extending from the barrel portion, an ultrasonic transducer received at least partially within the barrel portion of the housing, a waveguide operably coupled to the ultrasonic transducer and extending distally from the housing to a blade configured to treat tissue with ultrasonic energy produced by the ultrasonic transducer and transmitted along the waveguide, and a fluid management system disposed within the housing. The fluid reservoir is configured for releasable engagement with the fixed handle portion to facilitate cooling of the blade with fluid.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple penetrators advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, nerve sensing, nerve stimulation, or ablation by application of energy. The catheter can include a proximal handle for the advancement of guide tubes and penetrators.

Abstract: A system and method for reducing the risk of contamination of interior regions of a needle guide which is disposed on an endocavity transducer, which system includes an elastic membrane forming a pocket which covers a needle exit hole in the needle guide. The pocket is disposed on a sheath which is both; disposed around the endocavity transducer and between the endocavity transducer and the needle guide.

Abstract: In a biopsy needle having a hollow tubular outer needle, an inner needle that is disposed in a hollow portion of the outer needle so as to be movable in the tube axis direction relative to the outer needle, and a recessed sample collection portion that is cut inward from a circumferential surface of the inner needle, an outer groove extending in the tube axis direction of the outer needle is provided on at least the distal end side and the rear end side of the sample collection portion in the inner needle, and a light guide member is disposed in the outer groove. At least a part of the light guide member is fixed by fillers filled in the outer groove.

Abstract: An atraumatic microsurgical forceps may include a handle having a handle distal end and a handle proximal end, an outer hypodermic tube having an outer hypodermic tube distal end and an outer hypodermic tube proximal end, a surgical blank having a surgical blank distal end and a surgical blank proximal end, and a plurality of atraumatic forceps jaws of the surgical blank each atraumatic forceps jaw of the plurality of atraumatic forceps jaws having an atraumatic forceps jaw distal end and an atraumatic forceps jaw proximal end. A compression of the handle may be configured to gradually close the plurality of atraumatic forceps jaws wherein the plurality of atraumatic forceps jaws initially contact at the atraumatic forceps jaws distal ends.

Abstract: A fluid cooling system for cooling a microwave antenna includes an energy source configured to supply microwave energy to a microwave antenna for ablating tissue, a fluid source, a centrifugal pump, and a cooling member coupled to the centrifugal pump and configured to contact the tube to cool fluid flowing through the tube.

Abstract: An atherectomy device for removing deposits such as plaque from an interior of a vessel including an outer member and a rotatable shaft positioned for rotational movement within the outer member and fixed axially within the outer member. A tip is mounted to the distal region of the rotatable shaft and is positioned distally of the distal end of the outer member to create a gap between the proximal end of the rotatable tip and the distalmost edge of the outer member. The rotatable tip has a longitudinal axis mounted to the rotatable shaft for rotation about its longitudinal axis upon rotation of the shaft, the shaft including a guidewire lumen for receiving a guidewire to enable over the wire insertion of the device.

Abstract: Method and system for controllably administering and/or withdrawing fluid from a patient. In one embodiment, the system may include a needle assembly, an ultrasound imager, a fluid supply storage unit, a waste storage unit, a fluid pump, and a foot pedal assembly. A syringe may serve as the fluid supply storage unit and the waste storage unit. The pump may include a bi-directional motor and a gear coupled to the motor. The gear may be engageable with a rack on the syringe plunger to drive the plunger either for fluid aspiration or infusion. Depression of one portion of the foot pedal assembly causes the motor to drive the gear in one direction, and depression of another portion of the foot pedal assembly causes the motor to drive the gear the other direction. The system may include a control device to keep pressure in the fluid path from exceeding a limit.

Abstract: A device and method for treating a patient with total or near total occlusion is provided. The device can be positioned in a blood vessel at a treatment site. An occlusion at the treatment site is enlarged by a catheter. The catheter can be advanced over a guidewire into the occlusion. One or more of [a] compression or torsion applied to the guidewire or [b] compression or torsion applied to the catheter body expands or creates a path through the occlusion. The expansions or creation of the access path can be by cutting or abrading the occlusion or by a shoe-horn effect.

Abstract: A conduit puncture alert method and apparatus are provided for a medical instrument having a flexible conduit through which a medical procedure is performed. In one embodiment, the flexible conduit is inserted into a subject. A highest degree of curvature of the conduit within the subject is sensed. A warning signal is then provided upon a condition that a curvature is sensed that exceeds a predetermined limit reflective of a maximum curvature permissible for a selected tool to be inserted through the conduit while avoiding puncturing of the conduit by the selected tool. For example, the method can be conducted with respect to a bronchoscope during a bronchoscopic procedure where a needle tool is to be used and the warning is given with respect to that tool when a conduit curvature is sensed that exceeds a predetermined limit determined with respect to the needle tool.

Abstract: Apparatuses, systems, and methods are described for selectively generating an aspiration flow within a surgical instrument. Particularly, the disclosure describes example vitrectomy probes operable to selectively generate an aspiration flow in relation to operation of the cutter of the vitrectomy probe. In some instances, one or more valves may be used to form a barrier or closure and create a piston effect in order to selectively generate an aspiration flow.

Abstract: A vacuum assisted handheld biopsy device includes a housing, a stylet slideable within a cannula, the stylet having a hollow tube portion and a tissue collection portion coupled together, an actuator slideable within the housing for driving at least one of the stylet and the cannula, a vacuum source in communication with the stylet, and an ambient air opening in selective communication with the vacuum source. The coupling of the hollow tube portion with the tissue collection portion provides a fluid flow path sufficient to provide a vacuum suction to the tissue collection portion. A stylet for a vacuum assisted handheld biopsy device includes a hollow tube portion and a tissue collection portion coupled together. The coupling of the hollow tube portion and the tissue collection portion provides a fluid flow path sufficient to provide a vacuum suction to the tissue collection portion.

Abstract: Vascular access system embodiments can be configured to remove gas and a piercing member from a catheter assembly. In some embodiments, vascular access systems can remove gas and at least a portion of a piercing member concurrently or simultaneously. In some embodiments, vascular access systems can remove gas before removing at least a portion of a piercing member. In several embodiments, a vascular access system can include a first barrel configured to remove gas and a second barrel configured to retract a piercing member.

Abstract: The present disclosure relates generally to the field of tissue removal and more particularly to methods and devices for use in medical applications involving selective tissue removal. One exemplary method includes the steps of providing a tissue cutting instrument capable of distinguishing between target tissue to be removed and non-target tissue, urging the instrument against the target tissue and the non-target tissue, and allowing the instrument to cut the target tissue while automatically avoiding cutting of non-target tissue. Various tools for carrying out this method are also described.

Abstract: This disclosure relates to drug delivery devices, systems, and methods. In some aspects, a drug delivery device includes an elongate member defining a fluid passage and an opening in fluid communication with the fluid passage, and a projection extending radially from the elongate member. A portion of the elongate member extending axially from the projection to a distal end of the elongate member has a length sufficient to allow the distal end of the elongate member to reach subdermal tissue of a patient when the elongate member is inserted into the patient and the projection is in contact with an outer surface of skin of the patient, and the opening is positioned at a location along the elongate member such that the opening is disposed within a dermis of the patient when the elongate member is inserted into the patient and the projection is in contact with the outer surface of the skin of the patient.

Abstract: Tissue sampling, processing and injection syringe device and methods of filtering and concentrating cellular components of tissue sample in situ within the device.

Abstract: Devices, systems and methods are described herein for sealing openings in an anatomical wall. A sealing system includes an elongate tubular support for delivery to an anatomical opening to be sealed, a cover of bio-compatible material covering a distal portion of the tubular support, and an anchor assembly, the anchor assembly being designed to secure the cover material to the opening. The anchor assembly can include a plurality of distal anchors and a plurality of proximal anchors, a button, ring or donut, and/or a C-clip. In some embodiments, the system further comprises a closure member for closing off an end of the cover material after removal of the tubular support.

Abstract: The present invention provides an improved curved blade shaver for abriding tissue associated with a surgical site, the curved blade assembly including a curved outer shaft in receipt of an substantially linear inner instrument having a flexible region adapted for rotation and reciprocal receipt within the curved outer shaft and presenting a shaving means for debriding the tissue. The curved outer shaft also includes a portal for reciprocal receipt of a substantially rigid instrument when desired.

Abstract: A variable stiffness catheter includes an elongate tubular body having proximal and distal body ends and defining a lumen extending longitudinally between a fluid inlet in the proximal body end and a fluid outlet in the distal body end. The catheter includes a vacuum responsive stiffener coupled with the elongate tubular body, which may include a stiffening medium such as an open cell foam having an expanded state and a vacuum collapsed state. The stiffening medium can transition between the expanded state at which it is relatively flexible and the vacuum collapsed state at which it is relatively inflexible via withdrawing fluid from the vacuum responsive stiffener by way of a vacuum device.

Abstract: An atraumatic microsurgical forceps may include a handle having a handle distal end and a handle proximal end, an outer hypodermic tube having an outer hypodermic tube distal end and an outer hypodermic tube proximal end, a surgical blank having a surgical blank distal end and a surgical blank proximal end, and a plurality of atraumatic forceps jaws of the surgical blank each atraumatic forceps jaw of the plurality of atraumatic forceps jaws having an atraumatic forceps jaw distal end and an atraumatic forceps jaw proximal end. A compression of the handle may be configured to gradually close the plurality of atraumatic forceps jaws wherein the plurality of atraumatic forceps jaws initially contact at the atraumatic forceps jaws distal ends.

Abstract: A biopsy device comprises a body, a needle, and a cutter operable to sever tissue protruding through a lateral aperture of the needle. A vacuum pump is in fluid communication with the cutter. A fluid pump is in fluid communication with the needle. A fluid pump actuation assembly is operable to actuate the fluid pump to deliver a bolus of fluid to the needle based on movement of the cutter. A valve assembly responsive to cutter movement is operable to selectively couple the needle with the fluid pump, couple the needle with atmospheric air, or seal the needle relative to the fluid pump and atmospheric air. The fluid from the fluid pump and atmospheric air cooperate with the vacuum to urge severed tissue samples proximally through the cutter. Components operable to actuate the cutter and the fluid pump include coaxial lead screws having different pitch diameters.

Abstract: A biopsy system comprising a probe and a holster. The probe comprises a rotatable needle portion a rotatable thumbwheel coupled with the needle portion and a rotatable tissue sample manifold. The holster is removably coupled to the probe. The holster comprises a selective engagement mechanism configured to selectively link rotation of the thumbwheel with rotation of the tissue sample manifold. A method of collecting tissue samples using a biopsy system unlinking rotation of the thumbwheel with rotation of the tissue sample manifold by actuating the selective engagement mechanism; and obtaining a tissue sample after the unlinking.

Abstract: A tissue sample holder for a biopsy device comprises an outer cup, a collection tray, and a flow restriction device. The outer cup defines a hollow interior. The collection tray separates the hollow interior into an upper chamber and a lower chamber while allowing fluid to pass between the two chambers through an opening in the collection tray. The flow restriction device selectively seals the opening thereby preventing fluid from passing from the lower chamber into the upper chamber. The flow restriction device may be operable to selectively seal the opening in response to a vacuum being induced within the upper chamber. The collection tray may have a shape (e.g., tapered, funnel-shaped, convex, etc.) selected to facilitate the flow of fluid toward the opening. The lower chamber may be coupled with an external fluid collection device. The lower chamber may define a larger volume than the upper chamber.

Abstract: An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool.

Abstract: Liquid to be injected from an injection nozzle is supplied through a liquid supply channel toward the injection nozzle. Negative pressure for sucking the liquid injected from the injection nozzle through a suction port is produced by a suction unit and guided through a suction channel toward the suction port. A bypass channel which bypasses the liquid supply channel on the upstream side with respect to the injection nozzle and connects with the suction channel is provided. The bypass channel is opened and closed by an opening and closing unit. According to this structure, flow of unnecessary liquid from the injection nozzle can be reduced by opening the opening and closing unit while injection of liquid is stopping.

Abstract: A method for diagnosing or treating disease associated with a gut or intestinal tract includes collecting samples of gut microbiota from along an intestinal tract of a patient; perturbing the intestinal tract of the patient; and obtaining a response of the perturbing the intestinal tract of the patient. The method can be implemented using one or more capsules designed for introducing stimuli into the gut or intestinal tract, observing the response to the stimulus, and treating the gut or intestinal tract in view of the response to the stimulus and further in view of acquired empirical data compiled into a database.

Abstract: This disclosure relates to drug delivery devices, systems, and methods. In some aspects, a drug delivery device includes an elongate member defining a fluid passage and an opening in fluid communication with the fluid passage, and a projection extending radially from the elongate member. A portion of the elongate member extending axially from the projection to a distal end of the elongate member has a length sufficient to allow the distal end of the elongate member to reach subdermal tissue of a patient when the elongate member is inserted into the patient and the projection is in contact with an outer surface of skin of the patient, and the opening is positioned at a location along the elongate member such that the opening is disposed within a dermis of the patient when the elongate member is inserted into the patient and the projection is in contact with the outer surface of the skin of the patient.

Abstract: A biopsy device includes a cutter defining a cutter lumen and a tissue sample holder for collecting tissue samples. In one example, the tissue sample holder includes a rotatable manifold, and has a plurality of chambers that are each configured to separately hold tissue samples. A tissue sample holder rotation mechanism is operable to rotate the manifold to successively index each of the chambers with the cutter lumen. A sensing system is configured to sense the rotational position of the manifold. A controller in communication with both the sensing system and the rotation mechanism is operable to control the rotation mechanism based at least in part on the position of the manifold as sensed by the sensing system. The sensing system may include a sensor in a fixed position and a rotating encoder wheel on a shaft that is used to rotate the manifold.

Abstract: An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component.

Abstract: The invention relates to a device for taking a liquid bone marrow sample (aspiration) and a solid bone sample (biopsy) in the same procedure, which can thus replace specialized needles for taking bone marrow and needles exclusively used for taking bone biopsies. The device for taking liquid bone marrow samples and a solid bone sample has a simple mechanism that uses two grooved clamps, it is easy to disassemble for sterilization and its handle is designed to perform the puncture easily. The needle of the device is hollow, and within it a guide is placed with two sections of different diameters. The guide makes it possible to open up the empty needle channel to allow the bone marrow liquid to flow and be extracted, and also to close the channel to be able to penetrate the tissue. The purpose of this invention is to combine the procedures of bone marrow aspiration and bone biopsy, thus reducing the patient's discomfort and the time needed for the procedure.

Abstract: A disposable tissue removal device comprises a “tube within a tube” cutting element mounted to a handpiece. The inner cannula of the cutting element defines an inner lumen and terminates in an inwardly beveled, razor-sharp cutting edge. The inner cannula is driven by both a rotary motor and a reciprocating motor. At the end of its stroke, the inner cannula makes contact with the cutting board to completely sever the tissue. An aspiration vacuum is applied to the inner lumen to aspirate excised tissue through the inner cannula and into a collection trap that is removably mounted to the handpiece. The rotary and reciprocating motors are hydraulically powered through a foot pedal operated hydraulic circuit. The entire biopsy device is configured to be disposable. In one embodiment, the cutting element includes a cannula hub that can be connected to a fluid source, such as a valve-controlled saline bag.

Abstract: Medical devices and systems, and methods of their use, are disclosed having configurations suitable for obtaining biological tissue samples suitable for analysis, such as biopsy, while minimizing undesirable collateral damage to surrounding tissue or minimizing air leaks. Certain disclosed medical systems provide for obtaining biological tissue samples, while preserving organ functionality.

Abstract: A biopsy device includes a biopsy sample extraction needle with a sample extraction end and a recovery end. A transport channel links the extraction end and recovery end. A pump is provided, and a multi-way valve is coupled in fluid communication with the biopsy sample extraction needle and the pump. The multi-way valve has a plurality of settings.

Abstract: A biopsy device comprises a body, a needle, and a cutter operable to sever tissue protruding through a lateral aperture of the needle. A vacuum pump is in fluid communication with the cutter. A fluid pump is in fluid communication with the needle. A fluid pump actuation assembly is operable to actuate the fluid pump to deliver a bolus of fluid to the needle based on movement of the cutter. A valve assembly responsive to cutter movement is operable to selectively couple the needle with the fluid pump, couple the needle with atmospheric air, or seal the needle relative to the fluid pump and atmospheric air. The fluid from the fluid pump and atmospheric air cooperate with the vacuum to urge severed tissue samples proximally through the cutter. Components operable to actuate the cutter and the fluid pump include coaxial lead screws having different pitch diameters.

Abstract: Tissue can be removed from a patient with a catheter or other medical device having a cutting member. A source of suction can be coupled to the device for suctioning removed tissue through a lumen in the device and out of the patient's body.

Abstract: A marker deployment tool may comprise a marker cannula having a lateral deployment aperture, a push rod slidably disposed within the marker cannula and a scalloped tip coupled to the distal end of the marker cannula. The scalloped tip may have a push rod recess configured to receive a portion of the distal end of the push rod such that the push rod does not appreciably extend out of the lateral deployment aperture when the push rod is actuated distally. The marker deployment tool may further comprise a magnet at or near the distal end. This magnet may be used in combination with a magnet or plurality of magnets disposed about an access chamber in a tissue sample holder to assist the user in aligning the marker deployment tool. The access chamber in the tissue sample holder may also include a valve, two valves, or a removable plug.

Abstract: An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component.

Abstract: A biopsy device, comprising a flexible coaxial structure, comprising an obturator within a sheath, the obturator being adapted to be displaced with respect to the sheath along the coaxial axis by a force applied at a proximal end; a disruptor, at a distal end of the obturator, adapted to disrupt a tissue surface to free cells therefrom, having a first position covered within the sheath and a second position freely extending beyond the sheath; an element, having a fixed position on the obturator, and a close clearance with respect to an inner surface of the sheath, such that a retraction of the obturator within the sheath causes an associated change in pressure in a space between the obturator distal to the element and the sheath, to thereby draw fluid proximate to an end of the sheath within the sheath.

Abstract: An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool.

Abstract: Methods and device for extracting and collecting tissue, which can be used for example in tissue engineering and grafting applications, are disclosed. In one embodiment, a device can include an outer tube. A rotatable shaft can be disposed within the outer tube can have a tissue harvesting tip formed on its distal end, the tissue harvesting tip being effective to excise tissue upon rotation thereof. A tissue collection device can be included to receive and collected excised tissue, and the tissue collection device can indicate the amount of tissue collected therein. For example, the tissue collection device can include a straining element which collects excised tissue and an indicator by which to assess the amount of collected tissue. In some embodiments, the tissue collection device can translate to indicate the amount of collected tissue.

Abstract: An access device places a medical article within a body space of a patient. The device has a needle section that includes an elongated body and a needle hub. The device further includes a dilator portion that has a dilator and a dilator hub. The dilator is coaxially disposed and slideable over the elongated body of the needle section. The device further includes a sheath section that has a sheath and a sheath hub. The sheath is coaxially disposed and slideable over the dilator. The device further includes a first locking mechanism operably disposed between the needle hub and the dilator hub to inhibit at least unintentional axial movement between the needle section and the dilator portion and a second locking mechanism operably disposed between the dilator hub and the sheath hub to inhibit at least unintentional axial movement between the dilator portion and the sheath section.