Wiping Or Dabbing Patents (Class 600/572)
  • Patent number: 10456118
    Abstract: A biological sample collection, storage, and transport device includes a collection assembly and a sheath, wherein the collection assembly includes a support shaft, a swab head, and a handle, the swab head mechanically couples to a distal support shaft end, the handle couples to a proximal support shaft end, and the collection assembly slideably couples to the sheath and is configurable in a retracted position with the swab head entirely disposed within the sheath or an extended position with the swab head extending outside of the sheath. A distal sheath end includes an aperture, the aperture having a circumference large enough to allow the swab head to pass through said aperture when the collection assembly is configured in the extended position, and a seal is applied to the distal sheath end after the swab head has collected a biological sample and the collection assembly has been reconfigured into the retracted position.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: October 29, 2019
    Assignee: IN HINDSIGHT LLC
    Inventor: Kathleen Mary McSherry
  • Patent number: 10433822
    Abstract: A system and a method for a medical diagnostic device are described herein. The medical diagnostic device can include an outer sleeve having a hollow interior and open distal and proximal ends, the outer sleeve being defined by a substantially tubular configuration including a proximal section having a substantially conical shape. A core is configured to be inserted axially within the outer sleeve. The core includes an axial inner cavity. The core is further defined by a proximal section having a conical shape substantially conforming to the proximal section of the outer sleeve. The core retains a diagnostic assembly, that can include at least one of a sample collecting assembly and an imaging assembly, that can be integrally or interchangeably attached and wherein the device can be utilized for self-patient or single patient use.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: October 8, 2019
    Assignee: Welch Allyn, Inc.
    Inventors: Lezanne de Koning, Robert L. Vivenzio, Raymond A. Lia, Tracy Bennett
  • Patent number: 10271826
    Abstract: A swab assembly for collecting a specimen from a patient includes an elongated shaft having a proximal end, a distal end, and a notch between its proximal and distal ends; a sheath having a proximal end, a distal end, and a lumen extending between its proximal and distal ends, wherein a portion of the elongated shaft is disposed within the sheath lumen, and the sheath is slidable relative to the elongated shaft; and a collection tip coupled to the distal end of the elongated shaft and configured for obtaining the specimen. The sheath is slidable between a first position in which the shaft notch is disposed within the sheath lumen and wherein the sheath protects the elongated shaft from breaking at the notch, and a second position in which the shaft notch is exposed out of the sheath lumen.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: April 30, 2019
    Assignee: HOLOGIC, INC.
    Inventors: Steven A. Scampini, Ryan P. Oliva
  • Patent number: 10274402
    Abstract: A biological sample collection device 10 is disclosed including a shaped sample collecting tip 20a, said tip at least being formed from a fibrous material mixed with a liquid to form a pulp, said pulp being solidified to form the shape of the tip.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: April 30, 2019
    Assignee: GE Healthcare UK Limited
    Inventors: Michael John Smith, Peter James Tatnell, Leonard Goren
  • Patent number: 10226609
    Abstract: The present invention relates to a dispensing mechanism (2) for delivery of pharmaceutical forms (4) into body holes and an applicator (I) comprising the novel dispensing mechanism (2). The pharmaceutical form dispensing mechanism (2) Comprises a rod (2A) connected to a flexible member (2B). One end of the rod is free from constraints in order to allow its axial movement. The other end of the rod is cooperatively connected to said flexible member (2B). The flexible member has a rounded or angular shape, being able to be deformed and being provided with shape memory. The flexible member (2B) extends in a direction perpendicular to the direction of a compression force applied to it and recovers its original shape when said compression force is withdrawn, thereby imparting, respectively, a forward or rearward movement to the rod (2A), namely when a part (2C) thereof is immobilized in the body (3) of the applicator.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: March 12, 2019
    Assignee: BEYONDDEVICES LDA
    Inventor: Rui Carlos Ribeiro Redol
  • Patent number: 10182796
    Abstract: Devices, and methods of use thereof, are provided for the collection of a biological sample during insertion into a human orifice. The device may include a body piece, an insertion piece extending from one end of the body piece, and a handle connected to the other end of the body piece. Upon rotation of the handle, a shaft housed within the body piece, with a collection end at a distal portion thereof, is extended from a retracted position to an extended position, such that the collection end exits an opening within the insertion piece. The angle of the body piece relative to the insertion piece may be configured for self-sampling of a vaginal sample in a seated position. The collection end may be a swab with a plurality of pinwheeling fins having leading edge oriented to collect the biological sample when the shaft is rotated in a given direction.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: January 22, 2019
    Assignee: EVE MEDICAL INC.
    Inventors: Victoria Jessica Ching, Evan Moses, Gilad Shoham
  • Patent number: 10144947
    Abstract: A method for the detection, identification and enumeration of microorganisms in a porous support including reaction medium powder throughout its thickness, the support having been dry-impregnated throughout its thickness by a dehydrated reaction medium. Further, a device is used and enables the method to be carried out.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: December 4, 2018
    Assignee: BIOMERIEUX
    Inventors: Marie-Pierre Montet, Christine Rozand
  • Patent number: 10130258
    Abstract: An assistive sample collection and storage assembly for collecting, transferring and storing a biological sample includes a sample collection device having a first portion and a second portion. The first portion is configured to receive a sample collection member. The assembly includes a sample storage device comprising a sample substrate configured to receive at least a portion of the biological sample from the sample collection member. The assembly is configured to exist in a first state and a second state. The sample collection member is disposed at a determined distance from the sample substrate in the first state. At least a portion of the sample collection member is in physical contact with at least a portion of the sample substrate in the second state. The sample collection member is configured to apply a determined amount of contact force between the collection member and the sample substrate in the second state of the assembly.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: November 20, 2018
    Assignee: General Electric Company
    Inventors: Ying Mao, Weston Blaine Griffin, Erin Jean Finehout, Ian Hart
  • Patent number: 10058687
    Abstract: An applicator for administering a liquid to a selected location of a patient includes a main body having an interior cavity and a flexible outer wall. A frangible ampoule is configured to contain the liquid and configured to be positioned within the interior cavity of the main body. A hypodermic tube having a proximal end attached to the main body and a distal end. An applicator tip attached to the distal end of the hypodermic tube to dispense the liquid.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: August 28, 2018
    Assignee: Summit Medical, Inc.
    Inventors: Zachary W. Miller, Kevin D. McIntosh, Daniel M. Broberg, Kevin Connelly
  • Patent number: 10054520
    Abstract: A system and method for eluting a sample from a swab are presented. The system includes a chamber dimensioned to receive at least a portion of the length of at least one swab, a fluidic channel connected to the chamber, and an actuator. The chamber has at least one wall being a flexible film. The fluidic channel is configured to at least one of introduce and expel liquids from the chamber. The actuator is configured to contact an outer surface of the flexible film such that movement of the actuator against the outer surface of the flexible film causes a respective movement of the at least one swab when the at least one swab is disposed next to an inner surface of the flexible film. The respective movement of the at least one swab elutes the sample from the at least one swab into the chamber.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: August 21, 2018
    Assignee: Stat-Diagnostica & Innovation, S.L.
    Inventors: Jordi Carrera Fabra, Rafael Bru Gibert, Anna Comengés Casas
  • Patent number: 10001482
    Abstract: More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: June 19, 2018
    Assignee: Quidel Corporation
    Inventors: Franz Aberl, Marcus Scheibenzuber, Robert P. Sambursky, Robert W. VanDine, Jose S. Sambursky
  • Patent number: 9999406
    Abstract: A biopsy device comprises a body, a needle, a cutter, and a tissue sample holder. The tissue sample holder comprises an outer cup and a cap. A tray retains severed tissue samples from a biopsy procedure. In some versions, the tray is selectively detachable from the cap in a one-handed operation by the user. The tray may be ejected into a sample container, such as a formalin cup. The cap may include a threaded portion that is configured to engage a complementary threaded portion of a sample container to seal the sample container once the tissue samples have been transferred to the sample container from the tissue sample holder of the biopsy device. One or more ports may be provided in the cap to manage excess fluid within the outer cup of the tissue sample holder, and/or to provide integrated access for a marker delivery device.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: June 19, 2018
    Assignee: Devicor Medical Products, Inc.
    Inventors: John A. Hibner, John S. Ehlert, James A. McCrea
  • Patent number: 9788819
    Abstract: A biopsy system comprises an introducer and a biopsy device. The introducer comprises a cannula and at least two leaves. The cannula comprises an ovular cross-section, an open distal end and an open proximal end. The ovular cross-section defines a lumen extending between the open distal end and the open proximal end. The ovular cross-section of the cannula includes at least two flat sides. The at least two leaves extend distally from the open distal end. At least a portion of each of the at least two leaves extend from a respective flat side of the at least two flat sides of the cannula. The biopsy device comprises a body and an elongate needle. The elongate needle extends distally from the body. The elongate needle includes an ovular cross-section defining two straight sides. The cannula of the introducer is configured to slidably receive the elongate needle of the biopsy device.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: October 17, 2017
    Assignee: Devicor Medical Products, Inc.
    Inventors: Robert M. Householder, Edward A. Rhad, Andrew Paul Nock, Kevin M. Fiebig
  • Patent number: 9788820
    Abstract: The present invention comprises methods and devices comprising a cutting element used to contact circumferentially and longitudinally the surface walls of the endocervical canal to provide for broad and complete contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endocervical curettage or screening pap smear. The device may provide for a reservoir for the obtained sample to be contained when removing from the cervical canal and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: October 17, 2017
    Assignee: FEMASYS INC
    Inventors: Kathy Lee-Sepsick, Max S. Azevedo, Jeffrey A. Marcus
  • Patent number: 9687243
    Abstract: Methods, devices and systems facilitate gastric retention of a variety of therapeutic devices. devices generally include a support portion for preventing the device from passing through the pyloric valve or esophagus wherein a retaining member may optionally be included on the distal end of the positioning member for further maintaining a position of the device in the stomach. Some embodiments are deliverable into the stomach through the esophagus, either by swallowing or through a delivery tube or catheter. Some embodiments are fully reversible. Some embodiments self-expand within the stomach, while others are inflated or otherwise expanded.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: June 27, 2017
    Assignee: BAROnova, Inc.
    Inventors: Daniel Rogers Burnett, Gregory W. Hall
  • Patent number: 9662096
    Abstract: Collection devices, kits and methods related to sample collection and analysis can be used to collect and store samples (e.g., biological samples) from a variety of sources and optionally, for analysis of such samples (e.g., forensics analysis, medical diagnostics, etc.). Methods of production and use thereof are described herein. A device for collecting a sample (e.g., a sample including nucleic acid) includes an outer protective housing and a collection tip operably coupled to a carrier. The collection tip includes a hydrophilic and at least partially soluble material (e.g., hydrophilic and at least partially soluble polycaprolactone (PCL)) and is movable (e.g., retractable) from a first protected position within the outer protective housing to a second collecting position outside the outer protective housing.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: May 30, 2017
    Assignee: DIOMICS CORPORATION
    Inventors: Thomas J. Kindt, John F. Steel, Beverly L. Wolgast, Ryan Lamer
  • Patent number: 9636088
    Abstract: A specimen collection or a specimen collection and testing device having an embossed or raised section. In one embodiment the device includes a first panel with one or more apertures for receiving specimen and a second panel having a removable tab, the removable tab aligned with the one or more apertures when the device is assembled such that depositing specimen through the one or more apertures deposits the specimen on the removable tab. A cover has one or more embossed (or raised) sections that align with the one or more apertures when the cover overlays the first panel, thus helping to prevent adherence of the specimen to the inner surface of the cover.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: May 2, 2017
    Assignee: IMMUNOSTICS, INC.
    Inventors: Vincent P. Lastella, Kenneth Kupits
  • Patent number: 9623409
    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: April 18, 2017
    Assignee: CUE INC.
    Inventors: Ayub Khattak, Clinton Sever, Paul Nelson, Ryan Cooper, Thomas Congdon, Justin Demartino, Raphael Shapiro, Mark Duncan
  • Patent number: 9580760
    Abstract: The invention includes a method of detecting the presence or absence of mold in a sample. The method can include the step of applying a sample suspected of containing the mold to a growth medium, optionally fragmenting the sample, associating the sample with a labeling agent, and detecting the presence or absence of the mold by detection of the labeling agent. The invention can also include a medium for growing mold that includes a stimulation agent.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: February 28, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: Angela M. Oppedahl, Steven J. Lasky, Dylan D. Baker, Daniel Buttry, Ann M. Steger
  • Patent number: 9540684
    Abstract: The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: January 10, 2017
    Assignees: MINDERA CORPORATION, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Tahir A. Mahmood, Tobin J. Dickerson, Nadir A. Mahmood, Petr Capek
  • Patent number: 9533307
    Abstract: Described is a system for the stabilization, conservation and storage of a nucleic acid, wherein the system comprises a test tube and a preferably freeze-dried stabilization mixture. Upon addition of a viscous bodily fluid to the mixture, the mixture dissolves and stabilizes the nucleic acid present in the bodily fluid.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: January 3, 2017
    Assignee: STRATEC BIOMEDICAL AG
    Inventors: Jens Beator, Norbert Wendt, Birgit Hoeding, Hans Joos
  • Patent number: 9526876
    Abstract: The present invention is directed to a method and a device for accurately guiding a chest tube to an intended position within a pleural cavity of an animal or human being. There is also provided a kit-of-parts comprising a catheter and a catheter guiding device according to the present invention.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: December 27, 2016
    Assignee: Pieuratech APS
    Inventors: Peter Heydorn Kristensen, Niels Katballe
  • Patent number: 9492145
    Abstract: Methods of using a biological sample collection device comprising a collection portion and a body portion, the body portion including a holding portion for holding a biological sample storage medium, and a sample transfer means, such as a cover. The collection portion can be arranged in a first position separated from the body portion for collecting a sample, and in a second position at least partly between the sample transfer means and the holding portion, with the sample transfer means being operable to push the collection portion towards a position at which the holding means is arranged to hold the biological sample storage medium, enabling a sample held in the collection portion to be transferred to the latter.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: November 15, 2016
    Assignee: GE HEALTHCARE UK LIMITED
    Inventors: Alan Stuart Pierce, Cheryl Louise Potts, Simon Laurence John Stubbs, David Gwyn Treharne
  • Patent number: 9428788
    Abstract: A method for transferring a quantity of analytes comprising at least stages of: predisposing a substantially homogeneous mixture of a predetermined initial quantity of at least an analyte and a liquid, obtaining a known concentration value or known amount of the analyte in the mixture; introducing into the mixture at least a collecting portion (3) of a sampling device (1) having a support body (2), the collecting portion (3) comprising a plurality of fibers (6) attached to and arranged on a first portion (2a) of the support body (2) by means of flocking, in order to define a flocked collecting portion (3) or a flocked tampon, such as to collect a part of the mixture on the collecting portion (3); and extracting the collecting portion (3) of the sampling device (1) of the mixture, retaining on the sampling portion (3) a predetermined known quantity of the mixture to be transferred.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: August 30, 2016
    Assignee: COPAN Italia S.p.A.
    Inventor: Daniele Triva
  • Patent number: 9372186
    Abstract: The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: June 21, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Glenn T. Furuta, Steven J. Ackerman
  • Patent number: 9370775
    Abstract: The field of the present invention pertains to a controlled transfer biological collection device using a dry solid storage and transfer medium and a method for the collection of biological material of interest (genetic or proteinaceous material) in a form suitable for storage and/or subsequent analysis. Specifically, the present invention provides for a sampling device that controls the transfer of the biological sample to the storage medium by holding the storage medium and a moveable sample collection member having an analyte collection surface. The invention further provides for a method not only for storing a biological analyte on this collection device but also for analyzing the stored biological analyte using methods that are suited for automated analyzing systems.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: June 21, 2016
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Michael A. Harvey, Breck Olland Parker, Stevan Paul Tortorella, Elizabeth A. Moran, John Pipinias
  • Patent number: 9358089
    Abstract: The present invention relates generally to a system and method for measuring the structural characteristics of an object. The object is subjected to an energy application processes and provides an objective, quantitative measurement of structural characteristics of an object. The system may include a device, for example, a percussion instrument, capable of being reproducibly placed against the object undergoing such measurement for reproducible positioning. The structural characteristics as defined herein may include vibration damping capacities, acoustic damping capacities, structural integrity or structural stability.
    Type: Grant
    Filed: June 18, 2011
    Date of Patent: June 7, 2016
    Assignee: Perimetrics, LLC
    Inventors: James C. Earthman, Cherilyn G. Sheets
  • Patent number: 9320501
    Abstract: The present disclosure relates to a surgical instrument for sampling molecules in an organ which can be accessed directly or via a surgical portal, including: a device for capturing the molecules, a stylet supporting the capture device, capable of entering the organ, a guide for inserting the stylet into the body as far as the organ, wherein the distal end of the guide is provided with a damping block intended to come to bear upon the organ.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: April 26, 2016
    Assignees: Universite Joseph Fourier—Grenoble 1, Commissariat a L'Energie Atomique et Aux Energies Alternatives, Centre Hospitalier Universitaire de Grenoble
    Inventors: Renaud Montessuy, David Ratel, Emmanuel Gay, Jean-Guy Passagia, François Berger, Jean-Paul Issartel
  • Patent number: 9284593
    Abstract: The present invention provides methods to concentrate cells onto microparticles, to concentrate the microparticles, and to detect the cells. The present invention also includes unitary sample preparation and detection devices to be used in accordance with the methods.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: March 15, 2016
    Assignee: 3M Innovative Properties Company
    Inventors: Raj Rajagopal, Kurt J. Halverson, Manjiri T. Kshirsagar, James E. Aysta
  • Patent number: 9279747
    Abstract: Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: March 8, 2016
    Assignee: PURITAN MEDICAL PRODUCTS COMPANY, LLC
    Inventors: Terry Young, Timothy Templet, Paul Dube, Todd Dixon, Armand F. Lewis, Yong K. Kim
  • Patent number: 9265580
    Abstract: The devices and methods taught in this disclosure are directed to facilitate the observation, collection, transportation, storage, and preservation of specimens possibly containing DNA, said specimens potentially constituting evidence of sexual assault. The devices and methods described further allow for a means of minimizing the possibility of specimen contamination, dilution, or degradation during the collection and storage processes. The disclosed devices may contain electrical components that provide for the generation and recordation of information (specifically, times, dates, and locations) related to circumstances surrounding the collection of such specimens. This information may serve as evidence corroborating the circumstance of specimen collection, it may help to maintain a known and identifiable Chain of Custody (CoC), and it may additionally be used for unique device identification (UDI), inventory control, and current procedural terminology (CPT) coding purposes.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: February 23, 2016
    Inventors: Jonathan M. Speck, Ronald L Speck, Glenda Beth Horn Herring, Diana K Faugno, Rachell A Ekroos, Stacey A. Mitchell, Erik J. Ernst, John M. Hawkins
  • Patent number: 9241781
    Abstract: Implants are described herein which contain an activated adhesive on at least a portion of the surface of the implant. A release sheet may be positioned over at least a portion of the adhesive. Packages which contain the implants and methods of preparing the implants are also described.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: January 26, 2016
    Assignee: Covidien LP
    Inventors: Brian Nentwick, Ahmad Robert Hadba
  • Patent number: 9052254
    Abstract: Apparatus and methods are provided for evidence specimen collection having integral reagent holders to hold reagent vials and having drying agent or desiccant holding areas that permit the renewal of the desiccant and permit the introduction of variously size desiccant qualities to allow modulation of the specimen drying time to achieve early stabilization of specimens while holding the specimen in an isolated drying area during storage and shipment and for simultaneous collection of multiple evidence samples with simultaneous storage, drying, marking, evidence security and shipping provided and with the provision for simultaneous storage, drying, marking, evidence security and shipping provided for a control specimen.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: June 9, 2015
    Assignee: The Bode Technology Group, Inc.
    Inventor: Jangbir Sangha
  • Publication number: 20150148685
    Abstract: Devices and methods for profiling microbiota of skin are described which include a microbe profiling device including a device head and a hand-held housing, the device head including an epidermis-engaging component and an access window and configured to dislodge microbes from a skin surface, and the hand-held housing defining an opening aligned with the access window, the hand-held housing including a motor operably coupled to a motivatable component, a substrate disposed in relation to the motivatable component and including signal-generating complexes, a location-capture component to detect a location of one or more regions of the skin surface as the epidermis-engaging component contacts said one or more regions, at least one sensor component to detect one or more signals emitted from the signal-generating complexes, and a computing component including circuitry to associate the location of said one or more regions of the skin surface and the detected one or more signals.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 28, 2015
    Inventors: Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, JR.
  • Publication number: 20150148684
    Abstract: Devices and methods for profiling microbiota of skin are described which include a microbe profiling device including a device head and a hand-held housing, the device head including an epidermis-engaging component and an access window and configured to dislodge microbes from a skin surface, and the hand-held housing defining an opening aligned with the access window, the hand-held housing including a motor operably coupled to a motivatable component, a substrate disposed in relation to the motivatable component and including a microbe-capture region, a location-capture component to detect a location of one or more regions of the skin surface as the epidermis-engaging component contacts said one or more regions, at least one sensor component to detect one or more signals emitted or reflected from the microbe-capture region, and a computing component including circuitry to associate the location of said one or more regions of the skin surface and the detected one or more signals.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 28, 2015
    Inventors: Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, JR.
  • Publication number: 20150148265
    Abstract: Devices and systems for sampling and profiling microbiota of skin are described which include a replaceable microbe sampling unit including a substrate and a location information storage component, the substrate including a microbe-capture region configured to capture at least one type of microbe from one or more regions of a skin surface of an individual, and the location information storage component configured to store information associated with the location of said one or more regions of the skin surface of the individual.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 28, 2015
    Inventors: Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, JR.
  • Publication number: 20150148686
    Abstract: Devices and methods for profiling microbiota of skin are described which include a hand-held microbe profiling device including a housing defining an opening, the housing including at least one rotatable component at least partially disposed in the opening defined by the housing, an elongated flexible strip disposed on an outer surface of the at least one rotatable component, the outer surface of the elongated flexible strip positioned to contact one or more regions of a skin surface of an individual through the opening defined by the housing, a location-capture component to detect a location of one or more regions of the skin surface as the elongated flexible strip contacts said one or more regions, at least one sensor component to detect one or more signals emitted or reflected from the elongated flexible strip, and a computing component to associate the location of said one or more regions of the skin surface and the detected one or more signals.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 28, 2015
    Inventors: Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, JR.
  • Publication number: 20150148705
    Abstract: Systems and devices for sampling and profiling microbiota of skin are described which include a replaceable microbe sampling unit including at least one rotatable component, an elongated flexible strip, and a location information storage component, the elongated flexible strip including a microbe-capture region configured to capture at least one type of microbe from one or more regions of a skin surface of an individual, and the location information storage component configured to store information associated with the location of said one or more regions of the skin surface of the individual.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 28, 2015
    Inventors: Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, JR.
  • Patent number: 9033897
    Abstract: The present invention relates to a sampling instrument adapted for taking a sample in situ and in vivo or taking a sample ex vivo of a target tissue or body structure, in a maximum quantity of less than 10?6 g, the instrument comprising an elongated active member (10) with a distal operative end (11) having at least one retaining surface (12) arranged for contacting directly the target tissue or body structure, capturing and retaining molecules of the target tissue or body structure thereto.
    Type: Grant
    Filed: January 16, 2006
    Date of Patent: May 19, 2015
    Assignee: INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Alim-Louis Benabid, Ali Bouamrani, Jean-Paul Issartel, David Ratel, Francois Berger
  • Patent number: 8998824
    Abstract: Biological samples, such as saliva, are commonly collected on a swab and subsequently transferred to an absorbent storage medium. Embodiments of the present invention provide a biological sample collection device comprising a collection portion and a body portion, the body portion including a holding portion for holding a biological sample storage medium, and a sample transfer means, such as a cover. The collection portion can be arranged in a first position separated from the body portion for collecting a sample, and in a second position at least partly between the sample transfer means and the holding portion, with the sample transfer means being operable to push the collection portion towards a position at which the holding means is arranged to hold the biological sample storage medium, enabling a sample held in the collection portion to be transferred to the latter. This provides an improved means of collecting a biological sample.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: April 7, 2015
    Assignee: GE Healthcare UK Limited
    Inventors: Alan Stuart Pierce, Cheryl Louise Potts, Simon Laurence John Stubbs, David Gwyn Treharne
  • Patent number: 8992438
    Abstract: A device for collection of exfoliated cells from the rectal mucosa comprises a hollow, cylindrical body having an inflatable and invertible flexible membrane attached to one end thereof. Applying positive pressure to inflate the membrane after the device is inserted, preferably through a rectal access tube, into the rectum causes exfoliated cells to be collected on the surface of the membrane. Before removal of the device, negative pressure is applied and the membrane, along with the collected sample of exfoliated cells, is deflated, inverted and withdrawn into the body of the device, thereby avoiding contact of the collected sample with body surfaces or the rectal access tube as the device is removed from the rectum.
    Type: Grant
    Filed: July 6, 2005
    Date of Patent: March 31, 2015
    Assignee: Colonix Limited
    Inventors: Alexandre Loktionov, Andrew Humphrey Llewelyn, Rupert Charles Gifford Lywood, Tatiana Bandaletova, Colin George Ferrett, Hugo Geoffrey Gifford Lywood
  • Publication number: 20150072362
    Abstract: Methods, devices, systems, and kits useful for the collection and analysis of samples obtained by swabs are disclosed. Swab containers configured for receiving a swab containing a sample; cartridges for holding one or more of: a swab container, a swab, assay units, pipette tips, vessels, transport units, and implements; systems (which may include a sample processing device); kits; and methods for their use are disclosed. A swab container may include an entry port; an assay chamber having an assay port; a conduit comprising an interior channel connecting the entry port; and an interior channel providing fluidic communication between the entry port and assay chamber. An interior channel may be configured to squeeze a portion of a swab placed in or through the conduit. A cartridge may include a cartridge frame configured to receive one or more of swab containers, assay units, transport units, pipette tips, vessels or implements.
    Type: Application
    Filed: September 5, 2014
    Publication date: March 12, 2015
    Inventors: Clarissa Lui, Elizabeth A. Holmes
  • Publication number: 20150065379
    Abstract: The invention provides devices and methods for self-administered noninvasive retrieval of biological materials of the uterus and/or cervix. The cervical device comprises a receptacle with a variable volume receptacle cavity, a controller configured to change the volume of the receptacle cavity, a surface for collection of biological materials, and a flexible pouch for generation of suction to facilitate efficient retrieval of biological materials. The biological materials retrieved include various biomarkers of diseases and disorders of reproduction, are directly isolated from a site of pathology, and are not metabolized or diluted. Information generated by analyzing these biological materials permits early diagnosis and prognosis assessments of disease and disorders of the female reproductive organs, irregularities of pregnancy, anomalies of the fetus in utero, and microbial infections.
    Type: Application
    Filed: August 28, 2014
    Publication date: March 5, 2015
    Inventor: Mrinal K. Sanyal
  • Publication number: 20150057517
    Abstract: Disclosed are devices, compositions, and methods for diagnosing eosinophilic esophagitis in a subject. Also disclosed are methods for monitoring the course of eosinophilic esophagitis in a subject before, during, and after treatment.
    Type: Application
    Filed: March 27, 2013
    Publication date: February 26, 2015
    Inventors: Leonard F. Pease, Kathryn Peterson, Hedieh Saffari, Joseph R. Heath, Gerald Gleich, Kristin Leiferman
  • Publication number: 20150057574
    Abstract: Kits, devices, methods, and systems for assessing microbiota of a body surface and selecting treatment agents to apply to the body surface to modulate one or more types of microbes are described which include a kit including a plurality of treatment agents, a microbe sampling unit including a microbe-capture region, and an analyzer including a user interface, at least one sensor component, and a computing component with a processor and circuitry.
    Type: Application
    Filed: April 17, 2014
    Publication date: February 26, 2015
    Inventors: Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, Jr.
  • Patent number: 8961429
    Abstract: An arrangement for collecting a tissue or stool sample has a sample vial and a source of preservative fluid. A fluid valve controls a flow of the preservative fluid from the source of preservative fluid to the sample vial. An air equalization vent tube is coupled to the source of preservative fluid and an air valve controls a flow of air through the air equalization vent tube, the air valve and the fluid valve being actuated simultaneously. A scoop for collecting the sample is coupled to the sample vial coupler and extends into the sample vial. The preservative fluid flows from the source of preservative fluid to the sample vial by force of gravity upon actuation of the fluid valve. The air equalization vent tube transfers air from the sample vial to the source of preservative fluid upon actuation of the air valve.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: February 24, 2015
    Assignee: Wayne State University
    Inventors: Jeffrey L. Ram, Jordan Nechvatal, Ikuko Kato
  • Patent number: 8961896
    Abstract: A cytological cell sample collection, storage, and transport device is disclosed. The device comprises a sheath, a collection assembly, a base, and a containment vial. The collection assembly is slidably coupled to the base to expose a swab head comprising the collection assembly. The containment vial is configured to enclose the sheath and collection assembly within the internal volume defined by the containment vial and the base.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: February 24, 2015
    Assignee: In HindSight LLC
    Inventor: Kathy Mary McSherry
  • Patent number: 8920339
    Abstract: The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: December 30, 2014
    Assignee: Porex Corporation
    Inventors: Guoqiang Mao, James P. Wingo
  • Publication number: 20140378866
    Abstract: A cytological cell sample collection, storage, and transport device is disclosed. The device comprises a sheath, a collection assembly, a base, and a containment vial. The collection assembly is slidably coupled to the base to expose a swab head comprising the collection assembly. The containment vial is configured to enclose the sheath and collection assembly within the internal volume defined by the containment vial and the base.
    Type: Application
    Filed: November 21, 2011
    Publication date: December 25, 2014
    Inventor: Kathleen Mary McSherry
  • Patent number: 8852122
    Abstract: The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: October 7, 2014
    Assignee: Porex Corporation
    Inventors: Guoqiang Mao, James P. Wingo