Abstract: A method for collecting biological specimens using a swab of the type consisting of a rod terminating in a tip covered with fiber with hydrophilic properties to allow absorption of said specimens, wherein said fiber covers said tip in the form of a layer deposited by flocking

Abstract: A device, a kit, and a method of use thereof, for self-administration and collection of cervical cell tissue samples such as for Pap smear testing. The device comprises an insertion tube, within which is carried a movable cervical aligning tool with an aligning probe, and a cellular sampling tool with a cellular adhesion surface. The aligning probe and cellular adhesion surface can be selectively movable relative to the insertion tube to improve accuracy of the testing and user safety.

Abstract: Methods and apparatus are described for nucleic acid analysis of swab samples without the need for purification.

Abstract: A biological sample collection system is described comprising a biological sample collecting wand and a buffer container with a buffer solution. The biological sample collecting wand includes a handle and a sample collector detachably coupled to the handle. The sample collector include one or more sample protrusions, one or more sample apertures, or a combination thereof, at least the sample collector to removably insert into the buffer container.

Abstract: A sexually transmitted infection (STI) sampling device includes an elongated shaft that defines a first end separated from a second end, and an absorbent sampler coupled to one of the first and second ends. The absorbent sampler includes an absorbent core disposed on a longitudinal axis of the elongated shaft, and a plurality of fibers extending from the absorbent core. The plurality of fibers is configured to exfoliate and capture cells from a tissue surface of a patient, and the absorbent core is configured to absorb exfoliated cells not captured by the fibers.

Abstract: Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.

Abstract: A swab for collecting biological specimens is of the type consisting of a rod terminating in a tip covered with fibers with hydrophilic properties to allow absorption of said specimens, wherein said fibers cover said tip in the form of a layer deposited by flocking

Abstract: A liquid testing assembly for testing a liquid, the assembly comprising a test vessel and a stopper adapted to fit into a free end of the vessel. The stopper substantially hermetically seals the test vessel from the ambient. Further, the assembly includes a support coated with one or more identifying materials for identifying one or more constituents of the liquid. The support is fixed in the stopper and/or the vessel and extends into its interior for a predetermined distance. The liquid testing assembly when assembled is pre-evacuated to a predetermined vacuum sufficient to draw a predetermined volume of liquid to be sampled into the test vessel. The predetermined volume is of such an amount that it wets the one or more identifying materials ensuring identification of one or more constituents present in the liquid. A kit employing the liquid testing assembly is also discussed.

Abstract: A method of simultaneously collecting exocervical and endocervical cells from a female patient, includes providing a combination exo-endocervical sampling device including a sampler having a pair of opposing wings and a prominence extending from the wings. The opposing wings include a sampling surface and the prominence includes a multiplicity of endless looped fiber pairs distributed axially along a distal end section of the prominence. Each looped fiber pair includes a first loop extending transverse from the shaft and a second loop extending transverse from the shaft. The loops define a void space therebetween configured to capture exo-endocervical cells. The method includes placing the sampling device in contact with a cervix of the female patient, collecting exocervical cells with the opposing wings of the sampling device, and simultaneously collecting endocervical cells with the prominence.

Abstract: A nasal cleaning apparatus is described that includes a grip portion and a cleaning portion. The grip portion may include a handle and one or more gripping members attached to the handle. Such gripping members may facilitate rotation of the grip portion or other handling of the apparatus. The cleaning portion includes a head that is attached to a nasal cleaning cloth. The nasal cleaning cloth is disposed around and attached to the head, and is formed of a flexible, anti-microbial material. An extension member connects the cleaning portion to the grip portion. The nasal cleaning apparatus may be disposable and/or modular to facilitate multiple uses of all or only portions of the apparatus.

Abstract: Disclosed herein is test device and method for detection of sample analytes in which after sampling has occurred a closure is provided. Such a test device and method can be usefully employed to detect a variety of analytes including microorganisms.

Abstract: A cell sample collection and transfer device is provided. The device may include a plunger configured to slide to a plurality of positions for controlling an expandable tip. The expandable tip may be operable to collect cell samples from a target site. In one example, the expandable tip may be further operable to transfer the collected cell samples when placed in contact with a receiving surface. In another example, the expandable tip may be removed from the device and placed in a storage container for further processing.

Abstract: Disclosed is a specimen collecting device for collecting cell samples. The specimen collecting device has an extendible swab which can be extended and retracted during use. The extendible swab can also be inserted into the handle so that the samples can be stored, at least temporarily.

Abstract: The present invention discloses an apparatus for thin-layer cell smear preparation and in-situ hybridization, comprising at least one positioning device and a sealing device. The positioning device comprises at least one first opening. When the positioning device is set on a carrier device, the wall of the first opening and the carrier device form a cavity. The cavity is used to accommodate a cell suspension. The sealing device is provided on the positioning device for sealing the cavity to form an enclosed space.

Abstract: A unitized apparatus for collection and/or drying and/or transport and/or analysis of a specimen is provided having a desiccant chamber that permits variable quantities of desiccant to be loaded into the device and to allow the desiccant to be recharged within the device without contacting or causing damages to the specimen collected thereon.

Abstract: Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.

Abstract: The present invention is directed to methods of identifying and/or comparing humans. More particularly, the present invention is directed to methods of collecting human scent compounds from a subject, extracting the compounds, analyzing the compounds, and correlating the compounds to a unique compound profile for the subject. These unique compound profiles can be used to distinguish one subject from another, or to identify a specific subject based upon a sample.

Abstract: The invention relates to trans-epithelial frictionally abrasive tissue sampling devices for performing biopsies and methods of inducing an immune response against a pathogen, wherein epithelial cells containing the pathogen are disrupted with the frictionally abrasive tissue sampling device to introduce the pathogen into the bloodstream of a patient.

Abstract: A PAP smear sampling device includes a PAP smear brush having a base with peripheral bristles and a central brush for sampling both cervical and endo cervical areas. A break away handle is provided for supporting the brush from enabling depositing of the brush into a specimen capsule.

Abstract: The invention relates to pressure generating units, in particular to pressure generating unit arranged in the hand piece of a vacuum biopsy device in the form of a sirynge (2). In said units, air intake is open by a piston when said piston (5) is in the rear position thereof in the space of a vacuumed cylinder (11) which is switched for generating a superpressure, thereby initiating the outflow of a tissue liquid by the air introduced into the space of the vacuumed cylinder. For this purpose, the space of the vacuumed cylinder is connected to the space of an atmosphere pressure cylinder (12) arranged behind the piston, by means of a connection line (15), and an absorbing element (14) is placed on the piston axis.

Abstract: A combination exo-endocervical sampling device includes a pair of opposing wings disposed transverse to a shaft, and a brush that extends from the wings along a central axis of the shaft. In this regard, each of the opposing wings includes a sampling surface having a staggered array of beads, and the brush includes a multiplicity of looped fibers, where each looped fiber includes a first closed end opposite a second closed end such that the closed ends extend transverse from the central axis of the shaft.

Abstract: Coding for a sample carrier having at least a swab shaft and a piece of cotton wool or the like as sample collector, characterized in that said swab shaft (2) has a direct identification (5) in form of a barcode, a RFID-transponder or another technically accepted labelling, or which swab shaft (2) is alternatively firmly connected to a tube-shaped casing (4) carrying said identification (5).

Abstract: A method for predicting the presence of colorectal cancer based on the concentration of DNA in a sample of exfoliated cells collected directly from the surface of the rectal mucosa of a subject. The method consists of quantifying the concentration of DNA in a lysate containing exfoliated cells and correlating the concentration with a range within a statistical model which indicated the likelihood of the presence of colorectal cancer as well as the likely location of the cancer.

Abstract: Apparatus for quick screening for vaginal moisture pH level and for amine associated with such moisture, comprising a manipulable element including a probe insertable into the vagina; a pH indicator on a first side of the element, the indicator characterized as producing a color which corresponds to pH level of vaginal moisture contacting the indicator; and a second indicator on a second side of the element, the second indicator elongated lengthwise of the element and being an amine indicator, the second indicator having an outer surface exposed to vaginal moisture, the surface presenting a sequence of crests for collection of moisture between crests in response to movement of the element in the vagina.

Abstract: A kit and a method are disclosed for collecting and preparing a biological sample for testing where the sample is to be mixed with a buffer prior to being tested.

Abstract: An integrated wound dressing system and method including a bandage and a self-contained receptacle that stores treatment material for the care and treatment of wounds. The treatment material is easily accessible and can be removed from the receptacle through an exit. The treatment material can then be used to control bleeding and/or clean the wound before dressing. The bandage may include a layer of plastic that acts as an occlusion barrier to reduce heat loss and maintain moisture levels at the wound site. The occlusion barrier also acts to prevent the passage of air into or out of the wound site. The bandage also includes fasteners that act to prevent unintentional unraveling and to secure the bandage during final packaging. These fasteners help facilitate the wrapping of amputations, stumps, and extremities. The integrated wound dressing system provides an all-in-one system for treating and dressing wounds and reduces the time required to do so.

Abstract: A fecal sample collecting device and method. The device of an embodiment includes a removable first layer, having primary and secondary apertures and a second layer having a releaseable adhesive on an inner surface that secures the first and second layers, a flap aligned with the primary aperture, and an integrally formed removable tab. The device also includes a sheet between the two layers. In a first configuration, the sheet is aligned with the primary aperture such that a sample is deposited thereon when the device is used to wipe one's anus, and the removable tab is aligned with the secondary aperture such that a second sample is deposited thereon. Subsequently, the first layer is discarded, thereby exposing the adhesive on the inner surface of the second layer. The device is placed in a second configuration by folding the inner surface upon itself. Thus, primary and secondary samples are enclosed.

Abstract: This disclosure describes a swab extraction device that can be used to collect a medical specimen, transport the specimen to a laboratory, and process and analyze the specimen.

Abstract: A novel approach to the early detection of colorectal cancer (“CRC”), using a molecular diagnostic test to evaluate grossly normal-appearing colonic tissue for the early detection of colorectal cancer is disclosed. Such grossly normal-appearing colonic mucosal cells may be collected from non-invasive or minimally invasive procedures. The use of novel biomarker panels for drug screening also is disclosed. Such biomaker panels may be used wholly or in part as surrogate endpoints for monitoring effectiveness of a prospective drug in the intervention of pathologies, such as cancers, for example CRC, lung, prostate, and breast, and neurodegenerative diseases, for example Alzheimer's and ALS.

Abstract: A cell collector and cell collection method are provided for collecting clusters of cells for subsequent analysis of the cells to screen for abnormalities. The cell collector is designed to enhance the capability of the collector to pick-up clusters or clumps of cells, and to facilitate transfer of the collected clusters of cells onto a receiving structure, for example a slide. In one embodiment, a combination of the material of the collector, the texture of the collection surface of the collector, and the use of expansion and rotation of the collector during collection facilitate the collection of the clusters of cells.

Abstract: The presence of occult blood in feces is detected using device including a liquid tight packet containing a sheet of absorbent material impregnated with a liquid solution that reacts with feces to produce a color change when blood is present. The packet is opened manually by tearing the packet apart to access the sheet absorbent material, which is then used to collecting a sample of feces on the impregnated sheet of absorbent material.

Abstract: Handheld imaging and sampling probe systems, and related devices, kits, methods, etc., that may improve the general comfort of gynecological examinations and/or obtaining samples of cells from the vagina or cervix, and may also improve sample collection and thus possibly improve the sensitivity and specificity. The devices comprise an imaging and sample collection probe sized for easy and comfortable insertion into the vagina without requiring the use of a speculum comprising a proximally located handle and at least one relatively thin extension that extends distally from the handle. The probe further comprises at least one light emitter that emits illumination light toward the target tissue, at least one imaging system that detects and images examination light emanating from the target tissue, and a biopsy channel configured to transmit to the target tissue a retractable biopsy or surgical device able to retractably contact the target tissue, typically to obtain a sample of cells from the target tissue.

Abstract: The invention relates to a device for the withdrawal, collection and transport of biological specimens, comprising a test tube equipped with a cap comprising a membrane constructed of a soft material impermeable to liquids and pierceable by a suitable specimen withdrawal means.

Abstract: A first aspect of the present invention provides for devices to facilitate the release of sample materials from sample acquisition devices. The device comprises an abrasion element comprising at least one constriction or projection. A second aspect of the present invention provides for methods in which to use the devices to facilitate the release of sample materials from a sample acquisition device. Optionally, the device may contain at least one reagent to facilitate the release and/or detection of a microorganism, or component thereof, in a sample. Preferably, the devices and methods may be used in conjunction with a liquid medium in which the sample may be further processed.

Abstract: Devices to process a sample are configured to releasably attach a sample acquisition device to a drive mechanism that provides rotational and/or vibrational motion to the sample acquisition device. The devices can be used in sample processing methods to dislodge sample materials from the sample acquisition device. Sample processing methods using rotational or vibrational motion may further include the use of a liquid medium into which the sample is released. Sample processing methods may further include the detection of an analyte in the sample.

Abstract: Systems and methods of interrogating clusters of cells for two or more biological markers that do not, or rarely, occur in the same cell during normal cellular growth, development and function, to indicate the existence of cells that are part of a local area where a pre-neoplastic or neoplastic lesion may be present. The relationship among cells is maintained while interrogating the clusters of cells to facilitate the examination and determination of the existence of possible dysplasia.

Abstract: Apparatus for quick screening for vaginal moisture pH level as related to a pre-selected pH level, comprising a manipulable element including a probe insertible into the vagina, at least one pH indicator on the element, the indicator characterized as producing a color which corresponds to pH level of vaginal moisture contacting the indicator, and a local comparison zone on the element having a color corresponding to a predetermined pH level, and positioned and shaped for quick color comparison with the color of the indicator after indicator contact with vaginal moisture. A test site for vaginosis may also be located on the probe, in non-interfering relation with said indicator and/or said zone.

Abstract: A sample acquisition device includes a hollow shaft and a porous medium. The hollow shaft includes a proximal end, a distal end, and a sidewall extending between the proximal end and the distal end. The sidewall of the hollow shaft includes a plurality of openings adjacent the distal end of the hollow shaft. The porous medium is attached to the distal end of the hollow shaft and at least a part of the porous medium is positioned over the plurality of openings.

Abstract: The method of quickly screening for vaginal moisture conditions, that includes providing a manually manipulable element including a probe insertible into the vagina; providing one or more pH indicating first test site or sites on one portion of the probe; providing a vaginosis test site on another portion of the probe; manipulating the probe to transfer vaginal moisture to the sites, and, therefore, externally of the vagina, applying an hydroxide to the vaginosis test site, to come in contact with moisture at the vaginosis test site; and detecting presences of an amine or amines produced at the vaginosis site.

Abstract: A device for storage and transportation of forensic and/or biological material, comprising a sealable container and a material holder for holding the material, which holder can be placed in the container, wherein the container is provided with at least one ventilating hole and with sealing means that shut off the interior of the container from the environment.

Abstract: A system for deterring an attack and adding with identification and apprehension of an attacker is disclosed. A vessel containing materials capable of leaving stain, odor, or other markings on the attacker and the victim are employed. Comparison of the materials found on the victim and on the attacker will help establish the connection between the two and aid in the positive identification of the attacker. The system further provides for an audio and light alarm as additional ways for the victim to discourage the attacker. Also included is a tool that will aid the victim in escaping from the attacker's vehicle or other surroundings and a device that will help attract attention to the victim and the attacker. Alternatively, miniature devices are employed that remove samples of the attacker's skin, bone, hair, tissue or bodily fluids and store the same. Subsequent analysis of these samples enables identification of the attacker. Similar devices are also employed to lodge themselves into attacker's skin.

Abstract: This invention relates generally to medical devices, and more particularly, an apparatus and method for collecting cells or tissue samples from the cervix of a patient for medical testing.

Abstract: A segmented collector swab system includes a skewer and a plurality of absorbent pads assembled on the skewer in a kebobbed manner.

Abstract: A containerized low pressure sample collection apparatus includes an elongated tubular shaft with a vacuum connection at one end and a swab at an opposite end. The shaft extends through a housing which can be used as a handle. The housing is adapted to receive a cap at either end, at one end for storage and at the other to cover and protect the swab with a collected sample. A second slide-out of the apparatus embodiment includes a swab structure including a tubular shaft, a swab, and a centering structure which can be slid out of and back into a housing which can also be used as a handle to manipulate the apparatus to collect a sample. Both embodiments can be connected to a vacuum unit to draw air through the swab to collect certain kinds of samples.

Abstract: The present application describes a device for collecting biological samples comprising at least one collection protrusion comprising at least one tip; and at least one pad for contacting the tip.

Abstract: A method for collecting air-transportable evidence samples from objects and clothing: (a) utilizes a collection tube having open upstream and downstream ends, and at a point between these ends a constriction in the cross-sectional area of the tube, (b) utilizes an applicator stick having proximate and distal ends, the length of this stick being less than the length of the collection tube between its constriction and downstream end, and the distal end of this stick having an air permeable tip, (c) places the proximate end of the applicator stick in the upstream end of tube, (d) orients the stick so that its tip is proximate the tube constriction, and (e) imposes a suction force on the downstream end of the tube so that any air-transportable evidence sample proximate the upstream end of the collection tube is sucked into the tube and becomes lodged on the stick's tip.

Abstract: A mucous gathering device, comprising an elongated rotatable stem having a longitudinal axis, and a rotary headpiece carried at an end of the stem for angular flexing as the stem rotates, the headpiece having a face sized for presentation to the cervix entrance as the head rotates about an axis angled relative to the stem, the face having associated flexible means for gathering and retaining mucous proximate the cervix as the headpiece rotates, and a flexible rotary probe carried by the headpiece, the probe projecting forwardly and centrally relative to associated means and defining edges spaced apart to gather and propel mucous toward the headpiece in response to probe rotation in an opening defined by the cervix.

Abstract: A low pressure sample collection apparatus includes a double-ended cap member having similarly sized plug members extending from opposite sides, a vacuum connection nipple on one side and a shaft connection portion one the opposite, a passage extending through the cap from the nipple to the shaft connection portion, a tubular shaft connected to the shaft connection portion and having a sample collection swab member secured to an outer end thereof, and a container member having one end closed and an opposite end open. The cap member is reversibly plugged into the container either to use the container as a handle or to position the swab within the container for protection. A vacuum source may be connected to the assembly to draw air through the swab. The shaft may have a barrel telescoped thereon for separation of the swab from the shaft without contacting the swab.

Abstract: Apparatus and methods for endometrial biopsies, wherein an applicator is disposed on the distal end of an outer tube and an injection device is connected to the proximal end of the same tube. The applicator comprises one or more ridges on its outer surface that anchor the applicator in the cervical os, and that cause the applicator to remain securely positioned and maintain the os in a dilated position during the entire procedure. The ridges may be shaped like protrusions, scalloped edges or grooves, and may be disposed in a helical or circular pattern. A method for performing endometrial biopsies is also provided. The apparatus and methods according to the present invention are configured to minimize discomfort to the patient while facilitating the operation of the clinician.

Abstract: A kit for obtaining and shipping personal cell samples is provided. The kit contains such items as a transport tube, and collection swabs for obtaining a cell sample. The tube has a media plug impregnated with dehydrated media positioned within the tube near the top of a region of restricted diameter, and a compartment of rehydrating fluid located in a cap on the tube. Upon crushing the cap, the rehydrating fluid is released and rehydrates the media plug. When the collection swab is inserted into the transport tube, the swab pushes the rehydrated media plug through the region of restricted diameter and into the bottom of the tube. The collection surface of the swab thus maintains contact with the rehydrated media plug.