Abstract: A blood collection system may include a needle assembly, which may include a needle configured to receive an evacuated blood collection tube. The blood collection system may include a tubing, which may include a distal end and a proximal end. The proximal end may be coupled to the needle assembly. The tubing may include a first flow channel and a second flow channel. The first flow channel may be configured to collapse at a lower pressure differential than the second flow channel.

Abstract: A system for extracting and collecting a sample of a fluid of a user, comprising a sample collection device, comprising a sample container arranged to receive said sample; a cap arranged to cooperate with the sample container and having an incision mechanism movable in the cap by a triggering mechanism; a sealing mechanism; a sample extraction device, comprising a vacuum creation mechanism arranged to create vacuum in a vacuum chamber; and a valve control mechanism arranged to release the vacuum from the vacuum chamber to the sample collection device. The system simplifies collection of a fluid (e.g., blood) sample while keeping a high-quality standard for its analysis, minimizes the risk of injury due to handling the sample, reduces the risk of contamination of the collected sample, is compatible with standard blood analysers of central laboratories, requires minimal action from the user, and can collect large volumes of bodily fluid.

Abstract: Sterile connection systems and methods are disclosed. The systems and methods allow for connection of the facing ends of plastic tubing defining flow paths without welding or tube cutting. The two ends may be disconnected, re-sterilized and subsequently reused to make a new sterile connection.

Abstract: A bodily fluid collection device includes a needle part having a needle tube with a needle tip, and a capillary removably connected to a base end part of the needle tube in a longitudinal direction thereof on a side opposite to the needle tip. A method for collecting a bodily fluid using the bodily fluid collection device, and a method for collecting an aqueous humor using the bodily fluid collection device are also disclosed.

Abstract: A biopsy device includes a body, a needle, a cutter, a tissue sample holder, and a gate assembly. The needle extends distally from the body. The cutter is longitudinally translatable relative to the needle and defines a cutter lumen. The tissue sample holder is coupled proximally relative to the body. The cutter lumen of the cutter defines at least a portion of a fluid conduit extending between the cutter and the tissue sample holder. The gate assembly is configured to selectively arrest movement of a tissue sample holder within the fluid conduit between the cutter and the tissue sample holder.

Abstract: A method and system for buoyant separation of a target constituent of a sample, the method comprising: at a process chamber, combining a volume of substrates having a first density with the sample, thereby producing a population of target-bound complexes comprising the target constituent bound to at least a portion of the volume of substrates; within the process chamber, physically separating the population of target-bound complexes from the sample based upon interaction between the volume of substrates and an applied force; aggregating the population of target-bound complexes at a collection region of the process chamber; extracting the population of target-bound complexes from the process chamber; and processing the target constituent from the population of target-bound complexes for further analysis.

Abstract: An apparatus includes a fluid reservoir, a sterilization member, and a transfer adapter. The sterilization member operably couples to the fluid reservoir. The sterilization member is configured to be transitioned between a first configuration, in which the sterilization member obstructs an inlet surface of the fluid reservoir and maintains the inlet surface in a substantially sterile environment, and a second configuration, in which the inlet surface is unobstructed. The transfer adapter is configured to be placed in fluid communication with a portion of a patient. The transfer adapter is configured to move relative to the sterilization member from a first position to a second position such that a surface of the transfer adapter contacts the sterilization member to transition the sterilization member to the second configuration. The fluid reservoir is placed in fluid communication with the transfer adapter when the transfer adapter is in the second position.

Abstract: A device for collecting a physiological sample from a subject includes a lancet with a needle that is configured to puncture the subject's skin and a cartridge configured to engage with the lancet. The lancet is configured to transition the needle from an undeployed position to a deployed position in response to engagement with the cartridge, thereby allowing the needle to puncture the subject's skin.

Abstract: A blood sequestration device configured to isolate an initial, potentially contaminated portion of blood from the flow of blood of a patient, prior to directing the flow of blood to an outlet port where the blood can be accessed. The blood sequestration device including a body member having an interior wall defining a fluid conduit having a distal portion, a first proximal portion, and a second proximal portion, wherein the first proximal portion defines a sequestration chamber configured to isolate an initial portion of blood of a flow of blood, a vent path configured to enable the escape of gas initially trapped within the sequestration chamber.

Abstract: A device for collecting a physiological sample from a subject includes a lancet and a cartridge configured to couple to the lancet. The needle is configured to puncture the subject's skin. The lancet is configured to automatically deploy the needle when coupled to the lancet which allows the needle to puncture the subject's skin and draw a physiological sample. The device further includes a vial disposed within the cartridge. The vial is configured to receive the drawn physiological sample.

Abstract: A biological fluid collection device that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed. A biological fluid collection device of the present disclosure is able to effectuate distributed mixing of a sample stabilizer within a blood sample and dispense the stabilized sample in a controlled manner. In this manner, a biological fluid collection device of the present disclosure enables blood micro-sample management, e.g., passive mixing with a sample stabilizer and controlled dispensing, for point-of-care and near patient testing applications.

Abstract: A dermal patch for collecting a physiological sample includes a housing with a collection chamber, a sample channel and a pin within a receptacle of the housing. The sample channel is configured to direct a physiological sample drawn from a subject to the collection chamber. The pin is removably positioned within the receptacle and is configured to move from an undeployed position to a deployed position. The pin is configured to seal the receptacle when in the undeployed position and is further configured to facilitate generation of negative pressure in the sample channel when the pin is moved from the undeployed to the deployed position.

Abstract: A blood sequestration device configured to isolate an initial, potentially contaminated portion of blood from the flow of blood of a patient, prior to directing the flow of blood to an outlet port where the blood can be accessed. The blood sequestration device including a body member having an interior wall defining a fluid conduit having a distal portion, a first proximal portion, and a second proximal portion, wherein the first proximal portion defines a sequestration chamber configured to isolate an initial portion of blood of a flow of blood, a vent path configured to enable the escape of gas initially trapped within the sequestration chamber.

Abstract: A blood sample collection system, may include a housing, the housing including a blood collection port; and a baffle chamber; a needle formed through the housing and into the blood collection port; and a baffle formed within the baffle chamber to counteract a vacuum within a blood collection tube when pierced by the needle.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

Abstract: The present disclosure is a blood collection assembly that has a needle assembly fixedly coupled to a finger-activated actuator and tubing and the needle assembly has a needle. Further, the blood collection assembly has a hub that houses the needle assembly and the hub has a channel in a top surface of the hub. Additionally, the channel slidably engages the finger-activated actuator such that when the finger-activated actuator is moved from a distal end of the hub to a proximal end of the hub the needle retracts within the hub.

Abstract: The present invention discloses a disposable negative-pressure anterior chamber Paracentesis syringe which belongs to the technical field of medical supplies. It comprises nine parts, including a needle cap, a Paracentesis syringe, a needle base, an internal needle, a protective cover of the internal needle, an airlock, a needle tube, a collection tube and a collection tube rack. The invention has the advantages that it fixes the Paracentesis syringe during puncture and limits the depth of the needle insertion, releases the aqueous humor slowly to prevent a sudden drop of the intraocular pressure, reduces the risk of the intraocular infection by separating the anterior chamber from outside and the collection tube can collect and store the aqueous humor directly.

Abstract: A dermal patch for collecting a physiological sample includes a housing with a collection chamber, a sample channel and a pin within a receptacle of the housing. The sample channel is configured to direct a physiological sample drawn from a subject to the collection chamber. The pin is removably positioned within the receptacle and is configured to move from an undeployed position to a deployed position. The pin is configured to seal the receptacle when in the undeployed position and is further configured to facilitate generation of negative pressure in the sample channel when the pin is moved from the undeployed to the deployed position.

Abstract: A launching catheter for targeting a second vessel from a first vessel includes a catheter including a proximal portion and a distal portion including a needle aperture and a flat rectangular radiopaque marker. The flat rectangular radiopaque marker disappears under fluoroscopy upon rotation to provide information about rotational alignment of the launching catheter. The launching catheter includes a needle configured to extend through the needle aperture. A method of aligning the catheter includes rotating the catheter in a first blood vessel until the marker has a thickness (e.g., minimal thickness) under fluoroscopy. The thickness indicates rotational alignment of the catheter.

Abstract: In order to address an inability to separate portions of a sample and/or substance, in some embodiments, methods and apparatuses for separating components and/or portions of a sample are provided. For example, a sample collection container may comprise two areas within the container, one which is configured to contain a first volume of the sample, and one which is configured to contain a second volume of the sample. A float device may be configured to seal the portion of the container collecting the first volume from the portion of the container collecting the second volume, after the former portion of the container has been filled. The sample collection container may further comprise a top cap configured to further seal the two portions of the container, and to prevent leakage and/or spilling of the sample from the sample collection container.

Abstract: A blood sample collection system, may include a housing, the housing including a blood collection port; and a baffle chamber; a needle formed through the housing and into the blood collection port; and a baffle formed within the baffle chamber to counteract a vacuum within a blood collection tube when pierced by the needle.

Abstract: A fluid control device includes an inlet configured to be placed in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. The fluid control device has sequestration portion that can be vented or evacuated. The fluid control device has a first state in which an initial volume of bodily fluid can flow from the inlet to the sequestration portion and a second state in which (1) the initial volume is sequestered in the sequestration portion, and (2) a subsequent volume of bodily fluid, being substantially free of contaminants, can flow through at least a portion of the fluid control device and into the fluid collection device. The fluid control device can transition automatically or in response to an actuation of a portion of the fluid control device after the sequestration portion receives the initial volume.

Abstract: Systems and methods for enhanced implantation of an electrode lead for neuromuscular electrical stimulation of tissue associated with control of the lumbar spine for treatment of back pain, in a midline-to-lateral manner are provided. The implanted lead may be secured within the patient and used to restore muscle function of local segmental muscles associated with the lumbar spine stabilization system without disruption of the electrode lead post-implantation due to anatomical structures.

Abstract: A tubing system for use in a blood sampling-blood pressure monitoring system. The blood sampling-blood pressure monitoring system may include a control valve, a reservoir with a plunger, a sampling site, and a blood pressure transducer for measuring the blood pressure of a patient. The tubing system may comprise: a plurality of flexible tubing sections and a plurality of rigid tubing sections. The plurality of rigid tubing sections and flexible tubing sections may be interlinked with one another between the patient and the blood pressure transducer for the blood pressure measurement of the patient.

Abstract: A medical system, comprising an implantable access port including an implantable access port body and at least one implantable access port needle; wherein the at least one needle is concealable inside the access port body in a concealed position and is exposable outside the access port body in an exposed position; wherein the at least one needle is arranged within the access port body to penetrate outwardly through skin of a subject from within the subject when the access port is implanted in the subject; a transfer device coupled to the at least one needle of the access port, the transfer device configured to transfer a fluid to and/or from the access port; and wherein the transfer device is configured to form a closed system with the access port, wherein the transfer device includes a fluid flow passage configured to transfer the fluid to and/or from the access port.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

Abstract: The application relates to a blood collection device comprising: a cannula hub defining a chamber; an in-let cannula defining an axis and having a distal end and a lumen extending therethrough, the inlet cannula being mounted to the cannula hub such that the distal end of the inlet cannula is external of the cannula hub and such that the lumen through the inlet cannula communicates with the chamber; an outlet cannula having a proximal end and a lumen extending therethrough, the outlet cannula being mounted to the cannula hub such that the proximal end of the outlet cannula is external of the cannula hub and such that the lumen of the outlet cannula communicates with the chamber; a closed sleeve mounted over a portion of the outlet cannula disposed externally of the cannula hub; and a venting mechanism providing communication between the chamber and ambient surroundings.

Abstract: A biopsy device includes a body, a needle, a cutter, a tissue sample holder, and a gate assembly. The needle extends distally from the body. The cutter is longitudinally translatable relative to the needle and defines a cutter lumen. The tissue sample holder is coupled proximally relative to the body. The cutter lumen of the cutter defines at least a portion of a fluid conduit extending between the cutter and the tissue sample holder. The gate assembly is configured to selectively arrest movement of a tissue sample holder within the fluid conduit between the cutter and the tissue sample holder.

Abstract: The invention pertains to a system for identifying an animal comprising a male part (30), cooperating with at least one cutting element intended to cut out a sample of animal tissue, a female part (40) with open head having a through-channel, and a detachable device (50) for storing said sample, intended to be fixed to one end of said through-channel. According to the invention, the system also comprises means for closing said head that can take at least two positions, comprising an open position enabling the passage of said sample through the through-channel during a collecting operation, and an irreversible closed position by which the channel is closed in the vicinity of said one end (422) subsequently to the collecting operation.

Abstract: Apparatus and methods for a single, handheld device that provides for both insertion of a catheter and collection of a fluid. Some embodiments further include a needle that assists in the insertion of the catheter into a blood vessel, and which includes a retraction feature that protects the user from an accidental needle stick when the device is ready for disposal. Still further embodiments include a protective cover that prevents a user from accidentally being stuck by a second needle used for the introduction of the patient's blood into a collection device.

Abstract: The present invention discloses a disposable negative-pressure anterior chamber Paracentesis syringe which belongs to the technical field of medical supplies. It comprises nine parts, including a needle cap, a Paracentesis syringe, a needle base, an internal needle, a protective cover of the internal needle, an airlock, a needle tube, a collection tube and a collection tube rack. The invention has the advantages that it fixes the Paracentesis syringe during puncture and limits the depth of the needle insertion, releases the aqueous humor slowly to prevent a sudden drop of the intraocular pressure, reduces the risk of the intraocular infection by separating the anterior chamber from outside and the collection tube can collect and store the aqueous humor directly.

Abstract: The present disclosure provides a biological fluid collection device, such as a blood collection device, that is adapted to receive a multi-component blood sample having a cellular portion and a plasma portion and quickly, efficiently and cost-effectively separate the plasma portion from the sample. A pressure gradient can be applied across a separation member to facilitate movement of the plasma portion ahead of the cellular portion. The present disclosure allows for both passive and active plasma separation and dispensing.

Abstract: The present application relates to: (i) a sampler device for taking a sample of biological fluid, which comprises a capillary component, and a base rigidly connected to said capillary component and provided with a first connector capable of being reversibly attached in a leaktight manner to a second connector of a dispensing device; (ii) a dispensing device which also comprises means for transferring diluting fluid which open into said second connector. The application also relates to a biological analysis apparatus implementing the sampler and dispensing devices and to a method for sampling and dispensing a biological fluid.

Abstract: A disconnecting mechanism includes a main body including a fluid transfer tip having a tapered surface to form a friction fit with a corresponding connector. The lever member includes a threaded portion to enable the corresponding connector part to be connected to the fluid transfer tip by a screw fit in addition to the friction fit, and an actuator portion to actuate release of the friction fit. In a first pivotal position, the threaded portion has a first position close to the fluid transfer tip to engage with an outer thread or rim of the corresponding part and thereby form the screw fit in addition to the friction fit. In a second pivotal position, the threaded portion has a second position further away from the fluid transfer tip to disconnect the screw fit and the actuator portion is moved forward to push the connector part and release the friction fit.

Abstract: A valve (10) for permitting mixing of at least two components within a barrel (12) is provided including a stopper (20) configured for slidable liquid-tight engagement with an inner surface (13) of the barrel. The stopper is moveable between a first position and a second position and includes a proximal end (22), a distal end (24), and a channel (26) extending therebetween. The valve further includes a stationary body (30) comprising a base (32) and a stem (34), the stem being disposed within the channel of the stopper when the stopper is in the second position. When the stopper is in the first position, there is a liquid-tight seal in the channel, such that fluid flow through the channel is prevented. Movement of the stopper to the second position terminates the liquid-tight seal, thereby establishing fluid communication through the channel. A drug containing device and assembly for delivering a reconstituted drug are also provided herein.

Abstract: A flush syringe assembly comprises a barrel including a cylindrical side wall having an inside surface defining a chamber for retaining fluid, an open proximal end and a distal end having a passageway therethrough in fluid communication with the chamber. A plunger including an elongate body portion having a stopper at its distal end is provided. The stopper is slidably positioned in fluid-tight engagement with the inside surface of the barrel for driving fluid out of the chamber through the passageway. The stopper includes a distal portion and a proximal portion separated by a spring element and configured to compress when fluid is being driven through the passageway by motion of the plunger and to continue to drive fluid through the passageway after motion of the plunger has stopped.

Abstract: Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

Abstract: A method for using a single sample suspected of containing a microorganism for both a local rapid test immunoassay and a remote laboratory test. The sample is collected from a patient at a physician's office or from the environment to be tested. The sample is collected using a swab or other implement, combined with a rapid test processing reagent and a portion of the processed sample is used for the local rapid test. The rapid test processing reagent typically consists of a buffer, a salt, and a detergent and is compatible with the local rapid test immunoassay. Only a portion of the processed sample is used for the local rapid test, leaving a remaining portion of the processed sample to be used in a remote laboratory assay. At least some of the remaining portion of the processed sample is combined with a stabilization agent that preserves at least the nucleic acid in the processed sample for the remote laboratory assay.

Abstract: The present invention extends to a closed IV line draw system which may be used with a PIVC or another vascular access device to collect blood samples. The closed IV line draw system consists of various integrated components that allow the system to remain closed during the blood collection process. In this way, the closed IV line draw system simplifies the blood collection process and reduces the risk of contamination to the PIVC or other vascular access device.

Abstract: Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

Abstract: The present invention is directed to a method and container locator means for moving a container among one or more work-flow stations within an apparatus. The apparatus of the present invention may include a means for automated loading, a means for automated transfer and/or a means for automated unloading of a container (e.g., a specimen container). In one embodiment, the apparatus can be an automated detection apparatus for rapid non-invasive detection of a microbial agent in a test sample. The detection system also including a heated enclosure, a holding means or rack, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.

Abstract: A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.

Abstract: A medical article is configured to provide access to a patient's vasculature. The medical article includes an elongated body and a pair of stabilizing wings that extend from the elongated body and are configured to stabilize the medical article on a patient. The stabilizing wings are configured to rotate together or independently about the longitudinal axis of the elongated body between at least a first configuration and a second configuration. The elongated body can include a one-way valve disposed therein. The medical article can also one or more adhesive layers configured to releasably attach at least a portion of the wings to a patient.

Abstract: Disclosed is a device useful for preserving tissue samples after extraction from human or animal patients. The device includes a circular blade for taking a tissue sample, the blade being coupled to a sealing cap which mates to one end of a container. A retrieval port is also disclosed for extracting fluids from the container. Methods are also disclosed by which tissue samples may be taken and prepared for storage, processing, culture, or other analysis.

Abstract: The invention is related to an apparatus comprising: a valve body comprising two inlet openings, one outlet opening and a central space connecting the inlet openings and the outlet opening, and a spherical element movably contained inside the central space configured for translatory movement and configured to seal either the first inlet opening or the second inlet opening, wherein each of the inlet openings are configured for fluid communication with a first reservoir and with a second reservoir and wherein the outlet opening is configured for fluid connection with a septum. This apparatus solves the object to make the exchange of used parts including the valve construction less complex. A further object of the invention is to make the exchange easier to handle. The invention is also related to a medical device comprising a dispense interface and an apparatus of the afore-mentioned type.

Abstract: A catheter system including a collection member having an occlusion member and collection ports. At least one collection port being located distal to the occlusion member, and least one collection port being located proximal to the occlusion member.

Abstract: A multi-part device for separating plasma from whole blood is provided, with a sample taking unit for receiving whole blood, a filter unit with a layered filter with multiple layers for extracting plasma, and a pumping unit, typically a plunger pump, for creating a partial vacuum in the filter unit. The filter unit and a plasma collector vessel with a conical tip extending towards the filter unit are contained in a filter cartridge, which may be taken apart after plasma extraction, thus exposing the conical tip of the plasma collector vessel for sample input into an analyzer.

Abstract: A system for transferring solutions from a first cartridge into a second cartridge comprises a cartridge holder, a plunger driver, and a cartridge connector. The cartridge connector carries a transfer needle and an exhaust needle. The cartridge holder positions the first cartridge against the cartridge connector so that the transfer needle penetrates the first cartridge septum. The second cartridge is removably inserted into another end of the cartridge connector so that both the transfer needle and the exhaust needle penetrate the second cartridge septum. The plunger driver is disposed to advance a plunger on the first cartridge to transfer solution from the first cartridge into the second cartridge thus displacing solution from the second cartridge through the exhaust needle. The cartridge connector includes a sealed interior waste chamber for receiving the solution from the second cartridge.

Abstract: A medical device for use with a fluid transfer device includes a hub having an open proximal end with a frusto-conically-shaped cavity therein, a distal end and a passageway therethrough. The cavity is part of the passageway. A release element in the passageway of the hub is positioned to block fluid-tight engagement of the frusto-conically-shaped tip with the cavity of the hub. Structure is provided to release at least part of the release element, upon application of a proximally directed force on the hub, to allow the abrupt fluid-tight engagement of the tip and the cavity in the hub.

Abstract: Drug delivery connectors are provided for permitting and blocking fluid flow between a container and a catheter connector or other drug delivery site. Embodiments of the drug delivery connectors include a ball valve for forming a releasable seal within the drug delivery connectors. In one or more embodiments, the ball valve prevents fluid flow between an open proximal end and an open distal end of the drug delivery connector and is movable in a proximal direction to release the releasable seal to permit fluid flow from the open proximal direction to the open distal direction. Methods of delivering medication to a catheter connector that includes an actuator are also provided.