Abstract: Provided herein are compositions and methods for treating a subject with damaged tissue, such as an injury associated with a tissue to tissue (e.g., a connective tissue-to-connective tissue or tissue to bone) interface. One aspect provides an adhesive film or adhesive layer, optionally comprising a biomaterial, tissue growth factors, including CTGF/CCN2, or cells.

Abstract: A wound dressing is provided that includes at least a support including a thin pliable film with a top face and a bottom face, a pressure-sensitive adhesive layer applied to at least a portion of the bottom face of the thin pliable film, a protective layer applied detachably to the pressure-sensitive adhesive layer opposite the support and an additional layer either in the form of a uniform layer such as a film, or in the form of a frame, covering the top face of the thin pliable film. At least a part of at least the thin pliable film is trimmed in such a way that a space is created between the additional layer and the thin pliable film, the space providing a beginning for the easy removing of the additional layer.

Abstract: The invention relates to a medical product for a fastening duration of at least 7 days having good skin compatibility. The medical product includes a central adhesive compartment (3) and an over-patch. The over-patch is free of active ingredients and is formed from a water-vapor-permeable back layer (1) and an adhesive polymer layer (2) that is free of active ingredients. The invention further relates to a method for the production of the foregoing medical product, and to kits of parts containing laminates of layers 1 and 2.

Abstract: Adhesive tape for bonding that can be detached without leaving residue and without damaging the surface of a substrate when stretched in a direction of a bond plane. An adhesive tape includes an elastomeric backing having opposing first and second surfaces an acrylate pressure sensitive adhesive disposed on at least one of the first and second surfaces of the backing. The backing includes a copolymer selected from the group consisting of polyether-polyester, polyether-polyamide, and a combination thereof and from about 20 to 60 wt % of a tackifier, based on the total weight of the backing. The backing has an elongation at break greater than 500%.

Abstract: Devices, kits and methods described herein are provided for treatment to skin, including but not limited to wound healing, the treatment, amelioration, and/or prevention of scars or keloids. A book-like packaging, applicator and/or tensioning device can be used to apply a dressing to a subject. The packaging, applicator and/or tensioning device applies and/or maintain a strain in an elastic dressing, and include undulating edge configurations to reduce peak stresses applied to the skin compared to traditional dressing shapes.

Abstract: A tissue bonding article includes a flexible material, an adhesive substance applied over at least a portion of a bottom side of the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material.

Abstract: An article, such as a tissue bonding article, includes a flexible material, a polymerization initiator or rate modifier disposed in or on the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material, where the polymerization initiator or rate modifier is a polymerization initiator or rate modifier for the polymerizable adhesive composition.

Abstract: Adhesive articles containing microtopography, such as microprotrusions, and a coating of adhesive glue, such an adhesive having known toxicity and/or tissue reactive functional groups are described herein. The articles described herein contain a substrate, a plurality of microfeatures, and an adhesive, such as an adhesive glue. The articles described herein exhibit a 90° pull off adhesion of at least about 1.5 N/cm2. The articles described herein can contain less adhesive than when the adhesive is used alone without microtopography and yet exhibit equivalent adhesive strength with little or no toxicity or other adverse side effects (e.g., exothermic reaction).

Abstract: A catheter securement device that adheres to the skin of a patient having an epidural catheter or similar small flexible tube member inserted percutaneously, the securement device having a flexible, sheet-like main body member capable of adhering to the skin of the patient, a double notched pad member over which the catheter is bent, and a releasable retention member to secure the catheter onto the main body member.

Abstract: Devices, kits and methods described herein are provided for treatment to skin, including but not limited to wound healing, the treatment, amelioration, and/or prevention of scars or keloids. A book-like packaging, applicator and/or tensioning device can be used to apply a dressing to a subject.

Abstract: The present invention relates to a composition in the fluid form intended to form a dressing on the skin. This composition comprises from 6% to 12% by weight of the total weight of the composition of a cellulose derivative, from 5% to 15% by weight of the total weight of the composition of a vegetable oil, and a volatile solvent. The oil/cellulose ratio by weight is between 0.8 and 1.5. This novel dressing base makes it possible to obtain a film on the skin having satisfactory resistances to water and to rubbing actions. The film is flexible and sufficiently comfortable, in particular when the dressing is applied to a fairly extensive area of the skin.

Abstract: A nasal dilator and method of making nasal dilators are provided. The dilator may have a composite base element of at least two regions, the base element having an outer surface and an inner surface, the inner surface of the base element having a pressure-sensitive adhesive disposed thereon; the base element further including a spring element which imparts return memory into the base element so that the base element returns towards a planar conformation during use. The spring element has elastic memory effected by differential properties in the at least two regions.

Abstract: The present invention provides to a patch and a patch preparation having low stretchability, which can be continuously adhered to the skin for a long time without undesirable detachment and marked falling off from the skin due to various factors during adhesion, and specifically provides a low stretchable patch and a patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein a ratio P of the total length W (mm) of curved sections of a planar outer shape of the patch to the total length S (mm) of straight-line sections of the planar outer shape of the patch (W/S) is not more than 1.22, and, when the curved sections are approximated by a circular arc, the radius R (mm) of the circular arc is not less than 0.5 mm.

Abstract: A pubic patch is provided to apply to the pubic area of a woman, particularly the mons pubis (Pubic Mound) area of the pelvic region. The pubic patch includes an adhesive base with a front side and a back side with decorative material attached to the front side, and the back side attached to human body. The pubic patch may further comprise fragrances and/or illuminating devices. The decorative material may be hairs attached to supporting sheet or LED material. Further, a products kit is provided which contains a plurality of pubic patches. The product kit may include an instruction booklet. A method of using the pubic patch is also provided comprises the steps of selecting a pubic patch and applying the pubic patch to the human surface in the pubic area.

Abstract: A wound dressing is made of multiple layers and includes a collection chamber that is in fluid communication with a drainage channel. When applied over a wound, the wound dressing provides protection for the wound while allowing air and fluids to evacuate from the wound through the collection chamber and out through the drainage channel. The wound dressing can include a valve that restricts air and fluids from entering the wound, which is beneficial for treating pneumothorax.

Abstract: A bandage and method for securing a tension member comprising a central body and a plurality of tabs disposed about the central body. A tension member may be disposed across or through a slit or aperture of the central body. A body adhesive on the lower surface of the central body may secure the bandage to the patient. The tension member may then be pulled across the upper surface of the central body and a first tab may be folded over and adhered to the tension member and central body. The tension member may then be pulled back across the first tab and a second tab may be folded over and adhered to the tension member and first tab. Likewise, the tension member may then be pulled back across the second tab and a third tab may be folded over and adhered to the tension member and second tab.

Abstract: Systems and methods provide intraluminal delivery of a bandage structure within a body lumen or hollow body organ, e.g., for treating an injured gastrointestinal tract or an esophageal hemorrhage in a non-invasive way using endoscopic visualization. The systems and methods can be sized and configured to apply a chitosan bandage structure within a body lumen or hollow body organ, to take advantage of the mucoadhesive, antimicrobial, hemostatic, and potential accelerated wound healing properties of the chitosan material.

Abstract: A self-adhering bandage comprising: a carrier strip; adhesive layer disposed thereon; a gauze strip located approximately centrally on the carrier strip; a release paper covering the gauze strip and held in place by its adhering contact with the adhesive, thus forming a laminate; and an indicia incorporated in the adhesive layer that is transferable from the adhesive layer and a user's skin, when the bandage is removed from the user's skin.

Abstract: A device for the dressing of wounds and insertion sites of percutaneous and drug delivery devices provides 360 degree or complete circumferential protection of a wound or insertion site of a percutaneous or drug delivery device. In particular, the device is an integrated dressing for catheters comprising a pad and an adhesive dressing.

Abstract: A water-soluble pressure sensitive adhesive comprises a homogeneous blend comprising (a) a polymer selected from the group consisting of N-vinyl caprolactam homopolymers, N-vinyl pyrrolidone copolymers, and mixtures thereof and (b) a non-volatile plasticizer comprising a monohydric or polyhydric alcohol having hydrophilic-lipophilic balance of about 2 to about 10. The N-vinyl pyrrolidone copolymers comprise about 60% or less by weight N-vinyl pyrrolidone.

Abstract: Various systems, methods and materials are disclosed that enable efficient delivery of an agent into an adhesively adhered article, in which the agent elicits a desired outcome, on demand. This strategy, though general in scope, is also more specifically described with regard to enabling painless or atraumatic removal of products adhering to mammalian tissues such as skin and hair by suitably exploiting the ingress of an appropriate agent or like fluid. Other techniques and articles that aid in the handling or removal of such adhesive products are also disclosed.

Abstract: This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.

Abstract: Provided is a resin acid ester-based tackifier having a good compatibility with a synthetic rubber elastomer, being capable of reducing the melt viscosity of the elastomer, and being capable of imparting excellent adhesive properties and/or pressure-sensitive adhesive properties to the elastomer. The tackifier is composed of an ester composition characterized by (i) the ester composition comprising 70% by weight or more of a resin acid ester represented by the general formula (1): and (ii) the S?NMR/SNMR ratio of the ester composition being at least 6% in the 1H-NMR spectrum of the ester composition, wherein S?NMR is the total integral value of the proton signal(s) appearing in the region of 6 to 8 ppm and SNMR is the total integral value of all the proton signals appearing over the entire range of the 1H-NMR spectrum.

Abstract: The present invention relates to a wound dressing comprising at least a support comprising a thin pliable film (1) with a top face and a bottom face, a pressure-sensitive adhesive layer (2) applied to at least a portion of the bottom face of the thin pliable film (1), a protective layer (3) applied detachably to the pressure-sensitive adhesive layer (2) opposite the support and a additional layer (4) either in the form of a uniform layer such as a film, or in the form of a frame, covering the top face of the thin pliable film (1); said wound dressing is remarkable in that at least a part of at least the thin pliable film (1) is trimmed in such a way that a space (5) is created between the additionnal layer (4) and the thin pliable film (1), said space (5) providing a beginning for the easy removing of the additionnal layer (4).

Abstract: A wound closure system having first, second and third adhesive pads with a pair of strap members fixedly secured to the first and third adhesive pads. The pair of strap members are slidably received within the second adhesive pad. When the third adhesive pad is displaced, the first and second adhesive pads are displaced toward each other to close the wound.

Abstract: A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. The present invention further provides a method for treating a patient with a skin defect, consisting of (a) providing said patient with a composite consisting of a N-isopropylacrylamide (NIPAAm) layer polymerized with a biodegradable layer containing gelatin and a layer of polypropylene (PP) non-woven, wherein a bone marrow derived mononuclear cell with CD45 negative and glycophorin A negative is cultivating on the biodegradable layer; (b) covering said composite on the skin defect of the patient; and (c) treating the composite with water below 25° C. to strip off the layer of polypropylene (PP) non-woven.

Abstract: The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.

Abstract: A wound dressing and method of forming the same. In one embodiment, the wound dressing includes a two-sided adhesive band conformable to a surface of a person. The wound dressing also includes a removable bandage configured to attach to an upper surface of and seat over the two-sided adhesive band, thereby forming a substantially closed structure for application over a wound on the surface of the person.

Abstract: A method and device for reducing the damaging effects of radiant energy, blast, or concussive events includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during or before the incidence of the imparting event. Reducing blood outflow from the cranial cavity increases intracranial volume and/or pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood outflow further increases the intracranial pressure and volume, and thereby increases the pressure and volume of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure and volume reduces the likelihood of brain injury and any associated loss of olfactory function.

Abstract: The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.

Abstract: A substrate based skin contact material formed from a hydrocolloid having a silicone based component extending over regions of the substrate surface. The adhesive is formed non-continuously over the substrate to provide areas devoid of adhesive to allow appreciable moisture transfer between the skin and substrate and improve the skin friendliness of the material during use and allow convenient removal with avoidance of skin irritation.

Abstract: The present invention relates to a pressure sensitive adhesive composition for skin application. The adhesive composition comprises 10-50% (w/w) based on the total adhesive composition of a polar part; 10-50% (w/w) based on the total adhesive composition of an apolar part; and 0-60% (w/w) based on the total adhesive composition of hydrocolloid.

Abstract: Medical devices, wound dressings, and methods of dressing wounds are described. Devices and methods using silicone and pharmaceutically active agents are described. Devices including covers and bases are described.

Abstract: A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.

Abstract: A wound dressing provides a tenacious occlusive seal against the skin of a wearer, even in the presence of excessive blood or heavy perspiration. The preferred embodiment combines an adhesive backing layer with a hydrogel island providing superior hydrophilic gel adhesion. The product performs under extreme temperatures (i.e., 32-140° F.), and may be used to hold other dressings in place. The preferred embodiments are entirely translucent, and include a large pull-tab for easy removal. Two dressings may be packaged in a pliable re-sealable protective pouch, thereby forming a portable “kit.” Different “vented” embodiments are disclosed. A preferred structure includes a cover layer peripherally bonded to backing and hydrogel layers having a central aperture therethrough. The cover layer has one or more vent holes, and pressure is released through the central aperture and out the vent hole(s).

Abstract: The adhesive bandage consists of a support with one surface having pressure sensitive adhesive and a wound covering pad placed centrally on it, which are covered by two protective detachable tear away tabs. The tear away tab consists of a single layer over the adhesive surface of the support and becomes two layered over the pad region. The two layers are fused at the zone of fusion near the margin of the pad, but are otherwise free from each other. The layer close to the pad, called inner barrier layer, completely covers the pad area. The outer layer, also called grasping layer, partially covers the barrier layer and the pad, and is folded upon itself to give sufficient length. When the outer layer is grasped to pull apart the releasable tear away tabs the inner barrier layer prevents contact of the finger to the pad. As one pulls apart the tear away tabs the barrier layers unfold and prevent contact of the fingers with the wound and wound exudates, preventing cross contamination.

Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.

Abstract: A pressure sensitive adhesive composition includes 4-15 w/w % styrene-isoprene-styrene copolymer, 20-35 w/w % styrene-isoprene diblock copolymer, 4-15 w/w % tackifier, 6-18 w/w % paraffin oil, and 30-45 w/w % hydrocolloid. The size of the hydrocolloid is below 40 ?m.

Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

Abstract: An elongated flexible base strip is constructed with a bottom surface coated with an adhesive material. The base strip is constructed with bridging links which are spaced along the inner edge of the base strip and extend outward therefrom. The base strip, is cut to a first length and aligned with the wound with the bridging links extending over the wound. A matching portion of base strip is cut to a second length and aligned with the wound with the bridging links opposing. The opposing links are drawn together to close the wound. Adhesive on the links holds the links to the opposite base strip.

Abstract: The present invention relates to compositions of cyanoacrylate monomer, a method of improving the viscosity and the curing speed with a single additive and a process of providing sterilized cyanoacrylate adhesive compositions for application in the medical field.

Abstract: A wound closure system having first, second and third adhesive pads with a pair of strap members fixedly secured to the first and third adhesive pads. The pair of strap members are slidably received within the second adhesive pad. When the third adhesive pad is displaced, the first and second adhesive pads are displaced toward each other to close the wound.

Abstract: The invention provides an adhesive support article for supporting a body part of a user. A single-sided stretchable adhesive tape blank is precut into a sheet having a central anchoring portion and a plurality of outwardly extending fingers. The sheet is marked with visual indicators to guide the user of the support article for applying the central anchoring portion onto a first exterior surface of the body part and for stretching the fingers before adhering them at a predetermined distance away from the central anchoring portion. The adhesive support article can also be provided in a support system with at least one corresponding body landmark article, providing further guidance for applying the support article to the desired body part.

Abstract: A medical dressing is used to dress and treat skin wounds such as burns, cuts or traumatic injuries, and a method for making the same. The medical dressing includes an auxiliary release paper which makes it convenient to separate a pressure sensitive adhesive sheet from a release paper and is very easily separated from the pressure sensitive adhesive sheet after application to a wound site, thus improving the convenience of use of the dressing, and prevents the contamination of the pressure sensitive adhesive sheet in the process of either separating the pressure sensitive adhesive sheet from the release paper or separating the auxiliary release paper, thus preventing the secondary bacterial infection of a wound site, and is not exposed to the outside so that the dressing has an improved appearance and is convenient to carry and store.

Abstract: The medical protective cover includes a semi-ovoid shell configured to cover a wound or intravenous site. The shell is attached to a patient's limb or extremity by a pair of adhesive tabs extending from longitudinal ends of the shell and a plurality of adjustable straps extending laterally from the shell. A plurality of ventilation holes longitudinally extend along lateral edges of the shell to allow passage of air for keeping the covered area dry. Each longitudinal end of the shell includes a pair of tubing ports to facilitate mounting and passage of IV infusion tubing to an IV catheter or cannula. The top of the shell also includes a selectively opened slot that permits passage of a needle for the administration or withdrawal of fluids through an access port of the catheter.

Abstract: A self-adhesive wound care product, including a backing layer having a self-adhesive coating, preferably a silicone-gel adhesive coating, the backing layer of the product comprising a first area in which the adhesive coating has a first thickness, and a second area along at least a portion of the edges of the product. The second area has an adhesive coating having a thickness, which is less than the first thickness and which gradually decreases in a direction towards the edge of the product, from a thickness which is substantially equal to said first thickness to a thickness of 0-0.05 mm; or the second area is substantially free from adhesive coating.

Abstract: A self-adhering carrier enables application of an adhesive bandage without contact between the bandage's adhesive and the skin.

Abstract: A device for protecting an area of skin of a human body includes a plate. The plate includes a first face covered by an external layer and a second face opposite the external layer. The second face is configured to be applied onto an area of skin to be protected. The plate also includes a protective part made of a polymer gel and at least one adhesive part made of a polymer gel. The protective part is configured to ensure mechanical protection of the area to be protected and the adhesive part is configured to come into contact with the skin. The adhesive part has an adhesive power greater than an adhesive power of the protective layer to hold the plate on the area to be protected.

Abstract: Switchable adhesives comprising a mixture, in proportions by weight, of 20% to 98% of an adhesive, 2% to 80% of curable molecules and 0.05% to 10% of photoinitiator. Preferably, the adhesive and curable molecules are mutually soluble when dry or the curable molecules and adhesive may be uniformly dispersed in each other. Preferably the amount of adhesive in the mixture is in the range 40% to 98% by weight, more preferably 60% to 95% by weight, even more preferably 70% to 85% by weight. Preferably the proportion of curable molecules in the mixture ranges from 2% to 60% by weight, more preferably 5% to 40% by weight, even more preferably 15% to 30% by weight. Preferably, the photoinitiator is present in the mixture in the proportions 0.5% to 5% by weight, more preferably 1% to 3% by weight. Such switchable adhesives are useful in medical dressings and other removable sheet products, and may be simply prepared by stirring the adhesive, the curable molecules and the photoinitiator together at room temperature.

Abstract: A patch permitting division of only its release sheet by simply pulling right and left, wherein detachment of the release sheet is easy. There is provided a patch comprising a stretchable support, a plaster applied substantially all over one major surface of the support and a release sheet attached to the whole surface of the plaster wherein only the release sheet is divided at a division zone by simply pulling right and left, and wherein one or two or more precut parts that open when the patch is pulled right and left are disposed in the neighborhood on the division zone.